References on the Administration of Leptin Using ALZET® Osmotic Pumps

16298 Jeremie Boucher,, Samir Softic,, Abdelfattah El Ouaamari,, Megan T. Krumpoch,, Andre Kleinridders,, Rohit N. Kulkarni,, Brian T. O’Neill,, C. Ronald Kahn1  Diabetes 2016; 66(--):2201-2213. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (Fat-specific IR, IGF1R, and IR/IGF1R knockout mice; 3 month old); functionality of mp verified by blood glucose levels; dose-response (pg 2204-2206); behavioral testing (cold-resistance testing); replacement therapy (leptin); Lipoatrophic diabetes; Dose (10 ug/mouse/d);.

16286 Denroche, H. C., Glavas, M. M., Tuduri, E., Karunakaran, S., Quong, W. L., Philippe, M., Britton, H. M., Clee, S. M., Kieffer, T. J. Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity. Endocrinology 2016; 157(-7-):2671-85. >>> Leptin, recombinant mouse; SC; mice; 1007D, 1002; Controls received mp w/ vehicle; animal info (Male Leprflox/flox and Leprflox/flox Syn-cre mice, 12-14 wks); functionality of mp verified by plasma levels; pumps replaced after day 10; dose-response (pg. 2679); diabetes; Dose (10 ug/d or 20 ug/d);.

16187 Talton, O. O., Pennington, K. A., Pollock, K. E., Bates, K., Ma, L., Ellersieck, M. R., Schulz, L. C. Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice. Endocrinology 2016; 157(-7-):2636-48. >>> Leptin; Saline; SC; Mice (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, WT); stress/adverse reaction: (see pg. 2645); teratology; diabetes; Dose (350 ng/h);.

16099 Bruder-Nascimento, T., Butler, B. R., Herren, D. J., Brands, M. W., Bence, K. K., Belin de Chantemele, E. J. Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension. Pharmacol Res 2015; 102(--):235-44. >>> Leptin; Phenylephrine; SC; mice; 1007D; Controls received mp w/ vehicle; animal info: POMC Ptp1b−/− and Ptp1b+/+ mice; functionality of mp verified by blood pressure; cardiovascular; antihypertensive; Dose: leptin (10 ug/d); phenylephrine (7.2 and 20 mg/kg/day).

16072 Xu, S., Zhu, X., Li, H., Hu, Y., Zhou, J., He, D., Feng, Y., Lu, L., Du, G., Hu, Y., Liu, T., Wang, Z., Ding, G., Chen, J., Gao, S., Wu, F., Xue, Z., Li, Y., Fan, G. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Sci Rep 2016; 6(--):28508. >>> Leptin, rat recombinant; Saline, sterile; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (female, Lep114/114 or Wt); animal info (female, Lep114/114 or Wt); obesity.

15922 Nakazawa, M., Obata, Y., Nishino, T., Abe, S., Nakazawa, Y., Abe, K., Furusu, A., Miyazaki, M., Koji, T., Kohno, S. Involvement of leptin in the progression of experimentally induced peritoneal fibrosis in mice. Acta Histochem Cytochem 2013; 46(-2-):75-84. >>> Leptin; HCL; NaOH; SC; mice; 1002; controls received mp w/ vehicle PBS; Leptin dissolved in HCL and NaOH (1.25 mg/ml); animal info: male, C57BL/6, 22.6g; C57BL/6J-Lepob/Lepob, 37.3g; functionality of mp verified by Leptin serum concentrations, and peritoneal fluid-ELISA kit; dose: 0.45 g/kg/day.

15809 H. Pho,, A. B. Hernandez,, R. S. Arias,, E. B. Leitner,, S. Van Kooten,, J. P. Kirkness,, H. Schneider,, P. L. Smith,, V. Y. Polotsky,, A. R. Schwartz  J Appl. Physiol 2016; 120(--):78-86. >>> Leptin, recombinant; Saline; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (male, ob/ob, 23 weeks old); functionality of mp verified by leptin plasma levesl; stress/adverse reaction: (see pg. 81); pumps explanted after 3 days; Dose (30 ug/day);.

15237 Vaill, M.I., Desai, B.N., Harris, R.B.S. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 306(-4-):E414-E423. >>> Leptin, rat recombinant; PBS; CSF/CNS (third ventricle); Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); brain coordinates;.

15185 Palei, A.C., Spradley, F.T., Granger, J.P., Granger, J.P. Chronic hyperleptinemia results in the development of hypertension in pregnant rats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 308(--):R855-R861. >>> Leptin; IP; Rat (pregnant); 2ML1; Animal info (female, Sprague Dawley, GD14); cardiovascular; bp measured using indwelling catheter;.

15184 Ottaway, N., Mahbod, P., Rivero, B., Norman, L.A., Gertler, A., D'Alessio, D.A., Perez-Tilve, D., Perez-Tilve, D. Diet-Induced Obese Mice Retain Endogenous Leptin Action. Cell Metabolism 2015; 21(--):877-882. >>> Leptin receptor antagonist, non-pegylated; PBS; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (C57BL6J, Mc4r -/-, Lep ob/ob); Leptin receptor antagonist, non-pegylated aka LA;.

15168 Zeng, W.W., Lu, Y.H., Lee, J., Friedman, J.M., Friedman, J.M. Reanalysis of parabiosis of obesity mutants in the age of leptin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):E3874-E3882. >>> Leptin; acyl-ghrelin; growth hormone; SC; Mice; Controls received mp w/ saline; animal info (C57BL6J or db or clusterin KO, 6-8 weeks old); functionality of mp verified by leptin plasma levels; obesity;.

15149 Yan, C.L., Yang, Y.J., Saito, K.J., Xu, P.W., Wang, C.M., Hinton, AO Jr, Yan, X.F., Wu, Q., Tong, Q.C., Elmquist, J.K., Fukuda, M., Xu, Y., Xu, Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):3510-3521. >>> Leptin; meta-chlorophenylpiperazine; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6, 8 weeks old); obesity; meta-chlorophenylpiperazine aka mCPP;.

15131 Wang, M.Y., Yan, H., Shi, Z.Q., Evans, M.R., Yu, X.X., Lee, Y., Chen, S., Williams, A., Philippe, J., Roth, M.G., Unger, R.H., Roth, M.G. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):2503-2508. >>> Leptin, recombinant; pramlintide acetate; liraglutide; exenatide; SC; Mice (NOD); 2001; Controls received mp w/ PBS; animal info (female, NOD/ShiLtJ, 8 weeks old); pumps replaced every 7 days; long-term study; diabetes;.

15702 Jussara M. do Carmo,, Alexandre A. da Silva,, Zhen Wang,, Nathan J. Freeman,, Ammar J. Alsheik,, Ahmad Adi,, John E. Hall  Hypertension 2016; (-67-):378-386. >>> Leptin; Saline; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (RIS2 flox/flox or Nestin-cre, 22 weeks old); functionality of mp verified by leptin plasma levels; behavioral testing (air jet stress test; motor activity); cardiovascular; Dose (4 ug/kg/min);.

15111 Thieme, K., Oliveira-Souza, M., Thieme, K. Renal Hemodynamic and Morphological Changes after 7 and 28 Days of Leptin Treatment: The Participation of Angiotensin II via the AT(1) Receptor. PLoS One 2015; 10(--):U2677-U2695. >>> Leptin, recombinant rat; SC; Rat; 2ML1; 2ML4; Controls received mp w/ saline; animal info (male, Wistar, 150-250g); cardiovascular; peptides; bp measured using tail cuff;.

14916 Denroche, H.C., Kwon, M.M., Quong, W.L., Neumann, U.H., Kulpa, J.E., Karunakaran, S., Clee, S.M., Brownsey, R.W., Covey, S.D., Kieffer, T.J., Kieffer, T.J. Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol. DIABETOLOGIA 2015; 58(--):1100-1108. >>> Leptin, recombinant murine; Water; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-10 weeks old, STZ); functionality of mp verified by plasma levels; diabetes;.

14904 da Silva, A.A., Spradley, F.T., Granger, J.P., Hall, J.E., do Carmo, J.M., da Silva, A.A. Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling. JOURNAL OF NEUROPHYSIOLOGY 2015; 113(--):2786-2791. >>> Leptin; CSF/CNS; Rat; 2001; Animal info (male, Wistar, 14-16 weeks old, STZ); diabetes; after 7 days of infusion, ICV cannula was severed;.

14855 Burgos-Ramos, E., Canelles, S., Rodriguez, A., Gomez-Ambrosi, J., Frago, L.M., Chowen, J.A., Fruehbeck, G., Argente, J., Barrios, V., Barrios, V. Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2015; 415(--):157-172. >>> Leptin; BSA; CSF/CNS; SC; Rat; Controls received mp w/ saline; animal info (male, Wistar, adult, 250 +/-10g); 1% BSA used; diabetes;.

14532 Zhao, Z.J., Liu, Y.A., Xing, J.Y., Zhang, M.L., Ni, X.Y., Cao, E., Zhao, Z.J. The role of leptin in striped hamsters subjected to food restriction and refeeding. ZOOLOGICAL RESEARCH 2014; 35(--):262-271. >>> Leptin, recombinant murine; PBS; SC; Hamster; 1007D; Controls received mp w/ vehicle; animal info (male, Striped, 4-6 months old); functionality of mp verified by leptin serum levels; obesity;.

14478 White, J.T., DeSanto, C.L., Gibbons, C., Lardner, C.K., Panakos, A., Rais, S., Sharp, K., Sullivan, S.D., Tidhar, W., Wright, L., Berrigan, D., Heideman, P.D., Heideman, P.D. Insulins, leptin and feeding in a population of Peromyscus leucopus (white-footed mouse) with variable fertility. Hormones and Behavior 2014; 66(--):169-179. >>> Leptin, mouse recombinant; Saline; BSA; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (P leucopus); functionality of mp verified by serum levels; diabetes;.

14300 Meek, T.H., Matsen, M.E., Damian, V., Cubelo, A., Chua, SC Jr, Morton, G.J., Morton, G.J. Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats With Uncontrolled Diabetes. Endocrinology 2014; 155(--):4157-4167. >>> SHU9119; leptin; melanotan-II;; Saline; PBS; water, sterile; CSF/CNS; SC; Rat; mice; Controls received mp w/ vehicle; animal info (rat - male, Wistar, adult; mice - STZ-DM, AgRP-deficient or WT); functionality of mp verified by decreased insulin plasma levels; Multiple pumps per animal (2); diabetes; melanotan-II aka MTII; delayed delivery - catheters filled with saline; received drug on day 5; bilateral infusion for rat;.

14713 do Carmo, J.M., da Silva, A.A., Ebaady, S.E., Sessums, P.O., Abraham, R.S., Elmquist, J.K., Lowell, B.B., Hall, J.E., do Carmo, J.M. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2014; 307(--):R1438-R1447. >>> Leptin; Saline; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (Shp2 flox/flox or Shp2/Pomc-cre, 22 weeks old); behavioral testing (motor activity); cardiovascular; diabetes; bp measured using radiotelemetry; obesity study;.

14711 D'souza, A.M., Asadi, A., Johnson, J.D., Covey, S.D., Kieffer, T.J., Kieffer, T.J. Leptin Deficiency in Rats Results in Hyperinsulinemia and Impaired Glucose Homeostasis. Endocrinology 2014; 155(--):1268-1279. >>> Leptin, rat recombinant; Water; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Leptin KO, 16 weeks old); functionality of mp verified by plasma serum; diabetes;.

14709 Desai, B.N., Harris, R.B.S., Harris, R.B.S. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2015; 308(--):E351-E361. >>> Leptin; CSF/CNS (third ventricle; fourth ventricle); Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague Dawley, 275-300g); Multiple pumps per animal (2); tissue perfusion (third ventricle; fourth ventricle); bilateral infusion; one cannula to third ventricle second cannula to fourth ventricle; used plastics one cannula;.

14704 da Silva, R.P., Zampieri, T.T., Pedroso, J.A.B., Nagaishi, V.S., Ramos-Lobo, A.M., Furigo, I.C., Camara, N.O., Frazao, R., Donato, J.Jr, Donato, J.Jr  Endocrinology 2014; 155(--):4226-4236. >>> Leptin, mouse recombinant; SC; Mice; 1002; Controls received sham surgery; animal info (female, C57Bl6J ); behavioral testing (locomotor activity; energy expenditure); obesity;.

14680 Canton, E.D., Demas, G.E., Canton, E.D. Leptin mediates seasonal variation in some but not all symptoms of sickness in Siberian hamsters. Hormones and Behavior 2014; 66(--):802-811. >>> Leptin, recombinant murine; Tris buffer; SC; Hamster; 1002; Controls received mp w/ vehicle; animal info (male, Siberian, adult>60 days old); functionality of mp verified by blood levels; behavioral testing (nest building nehavior, anhedonic behavior, );.

14635 Dodd, G.T., Decherf, S., Loh, K., Simonds, S.E., Wiede, F., Balland, E., Merry, T.L., Muenzberg, H., Zhang, Z.Y., Kahn, B.B., Neel, B.G., Bence, K.K., Andrews, Z.B., Cowley, M.A., Tiganis, T., Tiganis, T. Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat. Cell 2015; 160(--):88-104. >>> Leptin; insulin, human; CSF/CNS; CSF/CNS (intra-arcuate nucleus of the hypothalamus); Mice; 1002; Control animals received mp w/ vehicle; animal info (8 wks old, C57BL/6); ALZET brain infusion kit (3) used; Plastics One bilateral cannula used with PEG tubing and a Y connector.

14627 Sakai, T., Kusakabe, T., Ebihara, K., Aotani, D., Yamamoto-Kataoka, S., Zhao, M.M., Gumbilai, V.M.J., Ebihara, C., izawa-Abe, M., Yamamoto, Y., Noguchi, M., Fujikura, J., Hosoda, K., Inagaki, N., Nakao, K., Kusakabe, T. Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 307(--):E712-E719. >>> Leptin, recomb.; exenatide; SC; Mice; 2002; Control animals received mp w/ saline; animal info (STZ induced diabetes, HFD 8 wks old); multiple pumps (2) implanted.

13998 Mercer, A.J., Stuart, R.C., Attard, C.A., Otero-Corchon, V., Nillni, E.A., Low, M.J., Low, M.J. Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 306(--):E904-E915. >>> Leptin; PBS; SC; Mice (transgenic); 1002; Controls received mp w/ vehicle; animal info (male, C57BL6 POMC-Discosoma red, 8-10 weeks old); functionality of mp verified by plasma leptin levels;.

13995 Bitton-Worms, K., Rostoker, R., Braun, S., Shen-Orr, Z., LeRoith, D. The Effect of Leptin Administration on Mammary Tumor Growth in Diabetic Mice. Hormone and Metabolic Research 2013; 45(-9-):655-659. >>> Leptin, recombinant mouse; SC; Mice; 2002; Controls received mp w/ saline; animal info (female, MKR, 8-10 weeks old); cancer (breast; mammary tumors); diabetes;.

13989 Watson, S.L., Watson, C.J., Baghdoyan, H.A., Lydic, R., Lydic, R. ADENOSINE A(1) RECEPTORS IN MOUSE PONTINE RETICULAR FORMATION MODULATE NOCICEPTION ONLY IN THE PRESENCE OF SYSTEMIC LEPTIN. Neuroscience 2014; 275(--):531-539. >>> Leptin, mouse recombinant; adenosine, N6-p-sulfophenyl; SC; Mice; 1002; Controls received mp w/ saline; animal info (male, B6 and B6.Cg-lep ob/J, 8-10 weeks old); functionality of mp verified by plasma levels; N6-p-sulfophenyladenosine aka SPA; SPA is an adenosine A1 receptor agonist;pumps removed after 14 days; obesity;.

13937 Zhao, Z.J., Chi, Q.S., Cao, J., Wang, D.H., Zhao, Z.J. Seasonal Changes of Body Mass and Energy Budget in Striped Hamsters: The Role of Leptin. PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY 2014; 87(--):245-256. >>> Leptin, recombinant murine; PBS; SC; Hamster; 1007D; Controls received mp w/ vehicle; animal info (striped hamster); functionality of mp verified by serum leptin levels;.

13914 Rodgers, H.M., Liban, S., Wilson, L.M. Attenuated pain response of obese mice (B6.Cg-lep(ob)) is affected by aging and leptin but not sex. PHYSIOLOGY&BEHAVIOR 2014; 123(-;-):80-85. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (ob/ob, B6.Cg-lepob, 41-42 weeks old]); behavioral testing (tail-flick, water intake); diabetes; used wound clips;.

13897 Petervari, E., Rostas, I., Soos, S., Tenk, J., Miko, A., Fueredi, N., Szekely, M., Balasko, M., Szekely, M. Age versus nutritional state in the development of central leptin resistance. Peptides 2014; 56(--):59-67. >>> Leptin, recombinant; Saline, pyrogen-free; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 3, 6, 12, 18, 24 months old); ALZET brain infusion kit used; cardiovascular;.

13881 Pichaiwong, W., Hudkins, K.L., Wietecha, T., Nguyen, T.Q., Tachaudomdach, C., Li, W., Askari, B., Kobayashi, T., O'Brien, K.D., Pippin, J.W., Shankland, S.J., Alpers, C.E. Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy. Journal of the American Society of Nephrology 2013; 24(-7-):1088-1102. >>> Leptin; Saline; SC; Mice; 2004; 2006; Controls received mp w/ vehicle; animal info (BTBR ob/ob, 18 weeks old); functionality of mp verified by leptin serum levels; replacement therapy (leptin replacement); diabetes; bp measured using tail cuff; long-term study;.

13836 Koch, C.E., Lowe, C., Pretz, D., Steger, J., Williams, L.M., Tups, A. High-Fat Diet Induces Leptin Resistance in Leptin-Deficient Mice. Journal of Neuroendocrinology 2014; 26(-2-):58-67. >>> Leptin; Cerebrospinal fluid, artificial; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (male, Lep ob/ob, 7 weeks old); behavioral testing (food intake); diabetes;.

13814 Iwasa, T., Matsuzaki, T., Munkhzaya, M., Tungalagsuvd, A., Kawami, T., Murakami, M., Yamasaki, M., Kato, T., Kuwahara, A., Yasui, T., Irahara, M., Iwasa, T. Pre-pubertal serum leptin levels and sensitivity to central leptin injection of prenatally undernourished female rats. International Journal of Developmental Neuroscience 2014; 35(--):52-54. >>> Leptin; Saline; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, PD28); functionality of mp verified by serum level; ALZET brain infusion kit 2 used; post op. care (ibuprofen, antibiotic ointment); diabetes;.

13797 Han, Y.M., Kang, G.M., Byun, K., Ko, H.W., Kim, J., Shin, M.S., Kim, H.K., Gil, S.Y., Yu, J.H., Lee, B., Kim, M.S., Kim, M.S. Leptin-promoted cilia assembly is critical for normal energy balance. Journal of Clinical Investigation 2014; 124(--):2193-2197. >>> Leptin; CSF/CNS; Mice; Controls received mp w/ saline; animal info (male, C57BL6, ob/ob, db/db, 12 weeks old); diabetes;.

13785 Goncalves, G.H.M., Li, W.J., Garcia, A.V.C.G., Figueiredo, M.S., Bjorbaek, C., Bjorbaek, C. Hypothalamic Agouti-Related Peptide Neurons and the Central Melanocortin System Are Crucial Mediators of Leptin's Antidiabetic Actions. CELL REPORT 2014; 7(--):1093-1103. >>> Leptin; SC; Mice; 2002; Controls received mp w/ PBS; animal info (diabetic, Let ob/ob, 8 weeks old); functionality of mp verified by serum levels; diabetes;.

13749 Cortes, V.A., Cautivo, K.M., Rong, S.X., Garg, A., Horton, J.D., Agarwal, A.K. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2(-/-) lipodystrophic mice independent of hepatocyte leptin receptors. Journal of Lipid Research 2014; 55(-2-):276-288. >>> Leptin, mouse recombinant; PBS; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (Agpat2 -/-); functionality of mp verified by plasma levels; pumps replaced every 2 weeks; post op. care (animals recovered on heating pad); behavioral testing (locomotor activity); Used wound clips;.

13663 Neumann, U.H., Chen, S., Tam, Y.Y.C., Baker, R.K., Covey, S.D., Cullis, P.R., Kieffer, T.J. IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice. Endocrinology 2014; 155(-3-):716-725. >>> Leptin, recombinant mouse; Water; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, ob/ob, 9 weeks old); functionality of mp verified by leptin plasma levels; diabetes; pumps primed in 37C saline for 48 hours;.

13655 Pandey, N.R., Zhou, X., Qin, Z.H., Zaman, T., Gomez-Smith, M., Keyhanian, K., Anisman, H., Brunel, J.M., Stewart, A.F.R., Chen, H.H. The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling. Journal of Neuroscience 2013; 33(-31-):12647-12655. >>> Leptin; Saline; CSF/CNS (third ventricle); Mice; Animal info (male, LMO4KO); behavioral testing (paired vs single feeding); diabetes; used guide cannula from Plastics One. used dental cement/screws.

13604 Li, Z.Y., Schmidt, S.F., Friedman, J.M. Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth. Diabetes 2013; 62(-7-):2359-2367. >>> Leptin; SC; Mice; 2004; Animal info (Cnrl double KO ob/ob, 12 weeks old); behavioral testing (food intake); diabetes; Pumps primed overnight in 37C saline;.

13308 Oury, F., Khrimian, L., Denny, C.A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.Y., Lee, H., Srinivas, P., Gao, X.B., Suyama, S., Langer, T., Mann, J.J., Horvath, T.L., Bonnin, A., Karsenty, G. Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions. Cell 2013; 155(-1-):228-241. >>> Osteocalcin; Leptin; SC; Mice; 1002; Animal info (female, 3 month old).

13287 Fujikawa, T., Berglund, E.D., Patel, V.R., Ramadori, G., Vianna, C.R., Vong, L., Thorel, F., Chera, S., Herrera, P.L., Lowell, B.B., Elmquist, J.K., Baldi, P., Coppari, R. Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin. Cell Metabolism 2013; 18(-3-):431-444. >>> Leptin; PBS; CSF/CNS; Mice; Controls received mp w/ PBS; Interesting paper; leptin administration permits survival and improves hyperglycemia of mice totally lacking insulin via CNS-dependent mechanisms. Leptin also lowers circulating and effect of glucagon. Effect is not through alpha pancreatic cells, but indirectly through hypothalamic GABA neurons; diabetes;.

13250 King, B., Jiang, Y., Su, X.Y., Xu, J.T., Xie, L.L., Standard, J., Wang, W.Q. Weight control, endocrine hormones and cancer prevention. EXPERIMENTAL BIOLOGY AND MEDICINE 2013; 238(-5-):502-508. >>> Insulin-like growth factor-1; leptin; SC; Mice; Animal Info (SENCAR mice); cancer (colon); cancer.

13237 Kacar, E., Dinc, S.E., Yilmaz, B., Kelestimur, H. Leptin regulation of pubertal maturation in intact and pinealectomized female rats. Turkish Journal Of Medical Sciences 2013; 43(-4-):557-561. >>> Leptin; SC; Rat; 1004; Animal info (Wistar, female).

13234 Harris, R.B.S. Leptin-induced increase in body fat content of rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 304(-3-):E267-E281. >>> Leptin; mutein; PBS; CSF/CNS (fourth ventricle); IP; Rat; 1002; 2002; Controls received mp w/ PBS, or saline; animal info (male, sprague dawley, 320-350 g); central administration of leptin through 4th ventricle, and effect on body fat mass; 0.15 ug leptin/24 hr, or 0.6 ug leptin/24 hr; 4th ventricle; multiple pumps (2).

13155 Mansuy-Aubert, V., Zhou, Q.L., Xie, X.Y., Gong, Z.W., Huang, J.Y., Khan, A.R., Aubert, G., Candelaria, K., Thomas, S., Shin, D.J., Booth, S., Baig, S.M., Bilal, A., Hwang, D., Zhang, H., Lovell-Badge, R., Smith, S.R., Awan, F.R., Jiang, Z.Y. Imbalance between Neutrophil Elastase and its Inhibitor alpha(1)-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure. Cell Metabolism 2013; 17(-4-):534-548. >>> Leptin, recomb. murine; SC; Mice; 1007D; Animal info (db/db, male, 10 wks old).

13154 Denroche, H.C., Quong, W.L., Bruin, J.E., Tuduri, E., Asadi, A., Glavas, M.M., Fox, J.K., Kieffer, T.J. Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice. Diabetes 2013; 62(-8-):2738-2746. >>> Leptin, recomb. murine; Water; SC; Mice; 2006; Control animals received mp w/ vehicle; animal info (C57BL/6, male); dose-response; 4 week pumps used; diabetes; long-term study;.

13142 Desai, B.N., Harris, R.B.S. Integrated Effects of Leptin in the Forebrain and Hindbrain of Male Rats. Endocrinology 2013; 154(-8-):2663-2675. >>> Leptin; Saline; CSF/CNS (third ventricle); CSF/CNS (fourth ventricle); Rat; 2002; Control animals received mp w/ saline; animal info (Sprague Dawley, male); Plastics One cannula used.

13138 Dubinion, J.H., do Carmo, J.M., Adi, A., Hamza, S., da Silva, A.A., Hall, J.E. Role of Proopiomelanocortin Neuron Stat3 in Regulating Arterial Pressure and Mediating the Chronic Effects of Leptin. Hypertension 2013; 61(-5-):1066-1074. >>> Leptin; IP; Mice; 1007D; Animal info (18 wks old, Stat3 flox/flox).

13099 Meek, T.H., Matsen, M.E., Dorfman, M.D., Guyenet, S.J., Damian, V., Nguyen, H.T., Taborsky, GJ Jr, Morton, G.J. Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia. Endocrinology 2013; 154(-9-):3067-3076. >>> Leptin; PBS; CSF/CNS; Mice; Control animals received mp w/ vehicle; animal info (STZ induced diabetes, Lepr wt, Lepr KO VMN); diabetes;.

13097 Supale, S., Thorel, F., Merkwirth, C., Gjinovci, A., Herrera, P.L., Scorrano, L., Meda, P., Langer, T., Maechler, P. Loss of Prohibitin Induces Mitochondrial Damages Altering beta-Cell Function and Survival and Is Responsible for Gradual Diabetes Development. Diabetes 2013; 62(-10-):3488-3499. >>> Leptin, human; SC; Mice; 1002; Control animals received mp w/ saline; animal info (8 wks old, Phb2 KO); diabetes;.

13070 Zhu, W.L., Zhang, L., Wang, Z.K. Effects of Exogenous Leptin on Body Mass, Thermogenesis Capacity and Hormone Concentrations of Yuman Chinese Vole, Eothenomys miletus, Under Varied Photoperiod. PAKISTAN JOURNAL OF ZOOLOGY 2013; 45(-4-):997-1006. >>> Leptin, recomb, murine; SC; Vole; 2001; Control animals received mp w/ PBS; animal info (E. miletus).

13052 Schroeter, M.R., Leifheit-Nestler, M., Hubert, A., Schumann, B., Glueckermann, R., Eschholz, N., Krueger, N., Lutz, S., Hasenfuss, G., Konstantinides, S., Schaefer, K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovascular Research 2013; 99(-3-):555-565. >>> Leptin, recomb. murine; SC; Mice; Control animals received mp w/ saline; animal info (male, apoE -/-, LDL-R -/-; cav-1 -/-, 10 wks old); long-term study; pumps replaced after 4 weeks.

12979 Arteaga-Solis, E., Zee, T., Emala, C.W., Vinson, C., Wess, J., Karsenty, G. Inhibition of Leptin Regulation of Parasympathetic Signaling as a Cause of Extreme Body Weight-Associated Asthma. Cell Metabolism 2013; 17(-1-):35-48. >>> Leptin; CSF/CNS (third ventricle); Mice; Control animals received mp w/ PBS; animal info (DIO-WT, 5 wks old); ALZET brain infusion kit 2 used; infusion rate of 0.5 ul/hr.

12956 Zhao, Z.J., Zhu, Q.X., Chen, K.X., Wang, Y.K., Cao, J. Energy Budget, Behavior and Leptin in Striped Hamsters Subjected to Food Restriction and Refeeding. PLoS One 2013; 8(-1-):U493-U502. >>> Leptin, murine, recomb.; PBS; SC; Hamster; 1007D; Control animals received mp w/ vehicle; animal info (striped).

12890 Huynh, F.K., Neumann, U.H., Wang, Y., Rodrigues, B., Kieffer, T.J., Covey, S.D. A Role for Hepatic Leptin Signaling in Lipid Metabolism via Altered Very Low Density Lipoprotein Composition and Liver Lipase Activity in Mice. Hepatology 2013; 57(-2-):543-554. >>> Leptin, recomb.; Mice; Animal info (Lepr flox/flox, Alb Cre ob/ob).

 

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What researchers are saying...

“...In comparison to bolus IP injection, continuous administration of angiogenesis inhibitors by an osmotic pump implanted IP resulted in a decrease of the required dosage and improved the effectiveness of therapy.” (p.451) Cheng et al., Neoplasia 2003;5:445-456