References on the Administration of Luteinizing Hormone and LHRH Using ALZET® Osmotic Pumps

11215 Mak, G.K., Weiss, S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nature Neuroscience 2010; 13(-6-):753-U134. >>> Prolactin, mouse, recomb.; luteinizing hormone, mouse, recomb.; antibody, prolactin neutralizing; Albumin, mouse, serum; PBS;; SC; CSF/CNS; Mice; 1003D; 1007D; Controls received mp w/ vehicle or normal goat antibody; animal info (8 wks old, Prlr +/+, Prlr -/-, male).

11186 Mak, G., Enwere, E., Gregg, C., Pakarainen, T., Pautanen, M., Huhtaniemi, I., Weiss, S. Male pheromone–stimulated neurogenesis in the adultfemale brain: possible role in mating behavior. Nature Medicine 2008; 10(-8-):1003-1011. >>> Luteinizing hormone; ara-C; Saline; SC; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (8-10 wks old, female, CD1).

8211 Bielinska, M., Seehra, A., Toppari, J., Heikinheimo, M., Wilson, D.B. GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Developmental Dynamics 2007; 236(-1-):203-213. >>> Luteinizing HRH, D-Trple; SC; Mice (nude); Replacement therapy (gonadectomy); peptides; animal info (female, NU/J, chimeric teratoma).

7798 Geiser, A.G., Hummel, C.W., Draper, M.W., Henck, J.W., Cohen, I.R., Rudmann, D.G., Donnelly, K.B., Adrian, M.D., Shepherd, T.A., Wallace, O.B., McCann, D.J., Oldham, S.W., Bryant, H.U., Sato, M., Dodge, J.A. A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation. Endocrinology 2005; 146(-10-):4524-4535. >>> Luteinizing HRH, D-Trple; Rat; Peptides; animal info (female, Sprague-Dawley, 270 g); GnRH agonist.

5271 Kim, I.S., Ariyaratne, H.B., Mendis-Handagama, S.M. Changes in the testis interstitium of Brown Norway rats with aging and effects of luteinizing and thyroid hormones on the aged testes in enhancing the steroidogenic potential. Biol Reprod 2002; 66(--):1359-1366. >>> Luteinizing hormone; Thyroxine; Saline; SC; rat; 2ML4; controls received mp w/ saline; functionality of mp verified by residual volume and plasma levels of LH&T4 via radioimmunoassay; dose-response (table, p. 1364); multiple pumps per animal (1-2): one for T4 and one for LH.

4719 Dondi, D, Moretti, R.M, Marelli, M.M, Pratesi, G., Polizzi, D, Milani, M, Motta, M, Limonta, P  Int. J. Cancer 1998; 76(--):506-511. >>> Luteinizing HRH agonist;; Propylene glycol; Water;; SC;; Mice (nude);; 2002;; controls received mp/vehicle; cancer (prostate); Zoladex was the LHRH agonist used;.

4509 Grzywacz, F.W., Chen, H., Allegretti, J., Zirkin, B.R. Does age-associated reduced leydig cell testosterone production in brown Norway rats result from under-stimulation by luteinizing hormone?. Journal of Andrology 1998; 19(-5-):625-630. >>> Luteinizing hormone, ovine;; Buffer, borate;; SC;; rat;; controls received mp with peanut oil; pulsed delivery-LH was alternated with peanut oil;.

15478 Mendis-Handagama, S.M.L.C., Watkins, P.A., Gelber, S.J., Scallen, T.J. The effect of chronic luteinizing hormone treatment on adult rat leydig cells. Tissue&Cell 1998; 30(-1-):64-73. >>> Luteinizing hormone; Borate buffer; SC; rat; 2002; controls received no treatment; peptides.

4067 Mendis-Handagama, S.M.L.C., Watkins, P.A., Gelber, S.J., Scallen, T.J. The effect of chronic luteinizing hormone treatment on adult rat leydig cells. Tissue&Cell 1998; 30(-1-):64-73. >>> Luteinizing hormone; Borate buffer; SC; rat; 2002; controls received no treatment; peptides.

3388 Matt, D.W., Dahl, K.D., Sarkissian, A., Sayles, T.E. Apparent absence of negative feedback in middle-aged persistent-estrous rats following luteinizing hormone-releasing hormone agonist treatment: relation to plasma inhibin and 17B-estradiol. Biol. Reprod 1993; 48(--):333-339. >>> Luteinizing HRH; Saline; SC; rat; peptides; D-Trp6,Pro9-NHEt-LHRH used.

3349 Becker, S.E., Johnson, A.L. Effects of gonadotropin-releasing hormone infused in a pulsatile or continuous fashion on serum gonadotropin concentrations and ovulation in the mare. J. Anim. Sci 1992; 70(--):1208-1215. >>> Luteinizing HRH; IV (jugular); horse; 2ML1; controls received no treatment; functionality of mp verified by LH plasma levels; comparison of iv pulsatile infusion vs. mp; peptides.

3340 McLeod, B.J., Brinklow, B.R., Curlewis, J.D., Loudon, A.S.I. Efficacy of intermittent or continuous administration of GnRH in inducing ovulation in early and late seasonal anoestrus in the pere davids deer hind (elaphurus davidianus). J. Reprod. Fertil 1991; 91(--):229-238. >>> Luteinizing HRH; Saline; SC; deer; 2ML2; functionality of mp verified by LH plasma levels; comparison of intermittent iv injections vs. mp; peptides.

3314 Jarow, J.P., Keeney, D.S., Robaire, B., Ewing, L.L., Zirkin, B.R. In vivo model for chronic direct intratesticular drug administration. J. Androl 1994; 15(-5-):456-461. >>> Luteinizing hormone; Buffer, borate; Albumin, bovine serum; SC; intratesticular; rat; 2002; controls received sham surgery, tubing only, or mp with buffer; tissue perfusion (parenchyma of testis); comparison of sc infusion vs. targeted infusion; peptides; no stress/stress; surgery and buffer infusion had no effect on spermatogenesis or steroidogenesis; localized inflammatory response to tubing; targeted delivery more effective than systemic infusion; ovine LH used.

3294 Gibson, M.J., Kasowski, H., Dobrjansky, A. Continuous gonadotrophin-releasing hormone infusion stimulates dramatic gonadal development in hypogonadal female mice. Biol. Reprod 1994; 50(--):680-685. >>> Luteinizing HRH; Saline; SC; mice; 2002; controls received mp with saline; pumps replaced after 2 weeks; peptides.

3236 Tilbrook, A.J., Galloway, D.B., Williams, A.H., Clarke, I.J. Treatment of young rams with an agonist of GnRH delays reproductive development. Horm. Behav 1993; 27(--):5-28. >>> Luteinizing HRH; SC; sheep; 2001; comparison of biocompatible implant vs. mp; long-term study, pumps replaced every 4 weeks; pumps placed in foreleg; pumps more effective than implants in suppressing LH and FSH secretion; D-Trp6-pro9N-ethyl amide-LHRH used.

3026 Ronayne, E., Enright, W.J., Roche, J.F. Effects of continuous administration of gonadotropin-releasing hormone (GnRH) or a potent GnRH analogue on blood luteinizing hormone and testosterone concentrations in prepubertal bulls. Domest. Anim. Endocrinol 1993; 10(-3-):179-189. >>> Luteinizing HRH; Leuprolide acetate; Saline; SC; cattle; 2ML4; controls received mp with vehicle; functionality of mp verified by plasma levels; long-term study, pumps replaced at 28 days; peptides.

2960 Pinski, J., Reile, H., Halmos, G., Groot, K., Schally, A.V. Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of androgen-independent Dunning R-3327-AT-1 rat prostate cancer. Int. J. Cancer 1994; 59(--):51-55. >>> SB-75; Luteinizing HRH; Propylene glycol; Water; SC; rat; 2ML4; Cancer (prostate); peptides; D-Trp6-LHRH used.

2771 Chamindrani Mendis-Handagama, S.M.L., Watkins, P.A., Gelber, S.J., Scallen, T.J. Leydig cell peroxisomes and sterol carrier protein-2 in luteinizing hormone-deprived rats. Endocrinology 1992; 131(-6-):2839-2845. >>> Luteinizing hormone; Borate buffer; SC; rat; 2002; no comment posted.

2629 Pinski, J., Halmos, G., Szepeshazi, K., Schally, A.V. Antagonists of bombesin/gastrin-releasing peptide as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer. Cancer 1993; 72(-11-):3263-3270. >>> RC-3095; Luteinizing HRH; Propylene glycol; Water; SC; rat; 2ML4; controls received injection of vehicle only; long-term study, pumps replaced after 4 weeks; cancer (prostate); peptides; agents given concomitantly in some cases; D-Lys6-LHRH used; 50 U/ml of heparin; animal info (SD, F, 200-250 g).

2589 Hyland, J.H. Uses of gonadotrophin releasing hormone (GnRH) and its analogues for advancing the breeding season in the mare. Anim. Reprod. Sci 1993; 33(--):195-207. >>> Luteinizing HRH; SC; horse; 2ML2; 2ML4; comprehensive review of other GnRH induced estrous studies (pp. 198-199).

2529 Pinski, J., Schally, A.V., Yano, T., Szepeshazi, K., Halmos, G., Groot, K., Comaru-Schally, A.M., Rakulovic, S., Nagy, A. Inhibition of growth of experimental prostate cancer in rats by LH-RH analogs linked to cytotoxic radicals. The Prostate 1993; 23(--):165-178. >>> Luteinizing HRH; Methotrexate; AJ-004; G-HMAQ; T-98; Propylene glycol; Water; SC; rat; 2ML4; controls received tumors and mp w/ vehicle; long-term study, pumps replaced after 4 weeks; cancer (prostate); toxicology; peptides; T-98 and AJ-004 are hybrid cytoxic LH-RH analogs; D-Lys6-LHRH used.

2420 Meseguer, A., Catterall, J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol. and Cellular Endocrin 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

2399 Khalid, M., Haresign, W., Hunter, M.G. Regulation of pitiuary GnRH receptors by continuous infusion of GnRH in the seasonally anoestrous ewe: evidence of ovarian involvement. Anim. Reprod. Sci 1991; 24(--):271-282. >>> Luteinizing HRH; Saline; SC; sheep; 2ML1; controls received mp w/ vehicle; functionality of mp verified by plasma levels of LH and estradiol.

2550 Ishimatsu, M., Nakamura, Y., Kato, H. Continuous luteinizing hormone infusion prevents atretic changes of the follicles during superovulation in hamsters. Endocrine J 1993; 40(--):665-671. >>> Follicle stimulating hormone, human; Luteinizing hormone; PBS; Albumin, bovine serum; SC; hamster; 2001; controls received mp w/ vehicles only; agents infused alone and in combination; human LH used.

2210 Debertin, W.J., Pomerantz, D.K. An investigation of the requirement for increased LH secretion during the compensatory response in androgen secretion after unilateral castration of the adult rat. J. Androl 1992; 13(-3-):199-207. >>> Luteinizing hormone; Saline; SC; rat; controls received empty mp; peptides; ovine LH used.

2038 Lowis, T.C., Hyland, J.H. The effect of an extended artificial photoperiod and gonadotrophin-releasing hormone infusions in inducing fertile oestrus in anoestrous mares. Aust. Vet. J 1991; 68(-12-):400-402. >>> Luteinizing HRH; Saline; SC; horse; peptides.

1980 Ainsworth, C.G.V., Hyland, J.H. Continuous infusion of gonadotrophin-releasing hormone (GnRH) advances the onset of oestrous cycles in thoroughbred mares on Australian studfarms. J. Reprod. Fertil 1991; 44(--):235-240. >>> Luteinizing HRH; Saline; SC; horse; 2ML4; peptides.

1971 Bretzlaff, K., Nuti, L., Scarfe, A., Elmore, R., Capehart, J., Varner, D., Weston, P. Luteinizing hormone and progesterone concentrations and induction of estrus after use of norgestomet ear implants or constant infusion of gonadotropin-releasing hormone in anestrous, nonlactating dairy goats. Am. J. Vet. Res 1991; 52(-9-):1423-1426. >>> Luteinizing HRH; SC; Goat; pumps placed on side of neck.

1876 Kang, I.S., Kuehl, T.J., Siler-Khodr, T.M. Effect of treatment with gonadotropin-releasing hormone analogues on pregnancy outcome in the baboon. Fertil. Steril 1989; 52(-5-):846-853. >>> Luteinizing HRH antagonist; Water; SC; Monkey (baboon, pregnant); no comment posted.

1854 Brannian, J.D., Terranova, P.F. Involvement of prostaglandins in LH-induced superovulation in the cyclic hamster. Prostaglandins 1991; 41(-2-):123-133. >>> Luteinizing hormone; Albumin, bovine serum; PBS; SC; hamster; 2001; no comment posted.

1844 Khalid, M., Haresign, W., Hunter, M.G., McLeod, B.J. Pituitary responses of seasonally anoestrous ewes to long-term continuous infusion of low doses of GnRH. Anim. Prod 1989; 49(--):95-102. >>> Luteinizing HRH; Saline; SC; sheep; 2ML4; peptides.

1842 Smith, C.J., Richards, J.S., Yasin, K., Sangster, J.N., Sridaran, R. Changes in rat luteal ultrastructure and P450scc mRNA and protein content after in vivo treatment with a gonadotropin-releasing hormone agonist. Biol. Reprod 1991; 44(--):382-391. >>> Luteinizing HRH agonist; SC; rat (pregnant); 2001; no comment posted.

1795 Rao, A.J., Chakraborti, R., Kotagi, S.G., Ravindranath, N. Effect of constant infusion of gonadotropin releasing hormone (GnRH) agonist buserelin and antagonist CDB 2085 A using osmotic minipumps on testicular function in adult male bonnet monkey (Macaca radiata). Andrologia 1990; 22(--):567-573. >>> Buserelin; Luteinizing HRH antagonist; Saline; SC; monkey; 2001; 2002; long-term study, pumps replaced every 36th day (2002) or every 30th day (2001).

1752 Henderson, K.M., Weaver, A., Wards, R.L., Ball, K., Lun, S., Mullin, C., McNatty, K.P. Oocyte production and ovarian steroid concentrations of immature rats in response to some commercial gonadotrophin preparations. Reprod. Fertil. Dev 1990; 2(--):671-682. >>> Luteinizing hormone; Follicle stimulating hormone; SC; rat; 2001; FSH-P, Folltropin, Oragen, Folligon; horse and porcine LH used.

1747 Schuiling, G.A., Moes, H., Koiter, T.R. Interdependence of oestradiol and 5a-dihydrotestosterone in modulating LH and FSH secretion in rats. J. Endocrinol 1989; 123(--):257-262. >>> Luteinizing HRH; SC; rat; 2001; controls received silastic sham; peptides.

1729 Sharma, O.P., Khan, S.A., Weinbauer, G.F., Arslan, M., Nieschlag, E. Effects of androgens on bioactivity and immunoreactivity of pituitary FSH in GnRH antagonist-treated male rats. Acta Endocrinol. (Copenh) 1990; 122(-2-):168-174. >>> Luteinizing HRH antagonist; SC; rat; silastic implants used for testosterone.

1725 Amir-Zaltsman, Y., Ausher, Y., Gayer, B., Lichter, S., Serour, F., Birkenfeld, S., Kohen, F. Pharmacological effects of the continuous administration of an LHRH agonist in the ageing male rat: comparison with orchidectomy. J. Endocrinol 1990; 124(--):261-268. >>> Luteinizing HRH-13; Saline; SC; rat; 2ML2; 2ML4; functionality of mp verified by blood vessels of LHRH-13.

1709 Mann, D.R., Gould, K.G., Collins, D.C. A potential primate model for bone loss resulting from medical oophorectomy or menopause. J. Clin. Endocrinol. Metab 1990; 71(-1-):105-110. >>> Luteinizing HRH agonist; SC; monkey; 2ML4; long-term study, pumps replaced every 4 weeks.

1695 Keeney, D.S., Sprando, R.L., Robaire, B., Zirkin, B.R., Ewing, L.L. Reversal of long-term LH deprivation on testosterone secretion and Leydig cell volume, number and proliferation in adult rats. J. Endocrinol 1990; 127(--):47-58. >>> Luteinizing HRH; Follicle stimulating hormone, ovine; SC; rat; 2002; peptides; ovine LHRH used.

1663 McVey, W.R., Williams, G.L. Effects of temporary calf removal and osmotic pump delivery of gonadotropin-releasing hormone on synchronized estrus, conception to a timed artificial insemination and gonadotropin secretion in norgestomet-estradiol valerate-treated cattle. Theriogenology 1989; 32(-6-):969-978. >>> Luteinizing HRH; Potassium phosphate; SC; cattle; 2001; pump placed s.c. in ear.

1628 Szende, B., Redding, T.W., Schally, A.V. Suppression of meiosis of male germ cells by an antagonist of luteinizing hormone-releasing hormone. Proc. Natl. Acad. Sci 1990; 87(--):901-903. >>> Luteinizing HRH antagonist; Propylene glycol; Water; SC; Mice (nude); 2002; comparison of SC injections vs. mp; pump replaced at 2 weeks; states mp is standard for continuous admin..

1605 Ataya, K.M., Sakr, W., Blacker, C.M., Mutchnick, M.G., Latif, Z.A. Effect of GnRH agonists on the thymus in female rats. Acta Endocrinol 1989; 121(--):833-840. >>> Luteinizing HRH; Radio-isotopes; Thymidine; 3H tracer; Saline; rat; 2001; 2002; dose-response (graph); 2001 pumps filled with tracer and saline only, pellets and silastic capsules also used, some 2002 pumps filled with LHRH.

1584 Johnson, D.C., Sen, M. The cytochrome P450(17a) (17a-hydroxylase/C17,20-lyase) activity of the junctional zone of the rat placenta. J. Endocrinol 1990; 125(--):217-224. >>> Luteinizing hormone; rat; ovine LH used.

1520 Berria, M., Joseph, M.M., Mead, R.A. Role of prolactin and luteinizing hormone in regulating timing of implantation in the spotted skunk. Biol. Reprod 1989; 40(--):232-238. >>> Luteinizing HRH; Saline; SC; skunk; 2001; long-term study; pump replaced weekly; peptides.

1500 D'Occhio, M.J., Gifford, D.R., Earl, C.R., Weatherly, T., von Rechenberg, W. Pituitary and ovarian responses of post-partum acyclic beef cows to continuous long-term GnRH and GnRH agonist treatment. J. Reprod. Fertil 1989; 85(--):495-502. >>> Buserelin; Luteinizing HRH; SC; cattle; 2ML4; dose-response; multiple pumps per animal (1 or 2) depending upon dose; functionality of mp verified indirectly by plasma levels; peptides.

1490 Kesler, D.J., Cruz, L.C., Sargent, G.F., McKenzie, J.A. The effect of constant delivery of GnRH on the episodic secretion of equine LH. J. Controlled Release 1988; 8(--):55-61. >>> Luteinizing HRH; SC; horse; 2001; functionality of mp verified in vitro; peptides.

1428 Schuiling, G.A., Valkhof, N., Koiter, T.R. Effect of estradiol on the secretion of LH in the GnRH-pretreated rat after treatment with the GnRH-antagonist, org 30093. Acta Endocrinol 1988; 119(--):582-588. >>> Luteinizing HRH; SC; rat; 2001; controls received silastic sham pump; pump replaced on day 5; peptides.

1399 Phillips, J.A., Lasley, B.L. Modification of reproductive rhythm in lizards via GnRH therapy. Ann. N. Y. Acad. Sci 1987; 519(--):128-136. >>> Luteinizing HRH analog, chicken; Peanut oil; IP; iguana; 2ML2; coiled catheter; continuous versus pulsed delivery both by mp; pulsed delivery; peptides.

1383 Sridaran, R., Ghose, M., Mahesh, V.B. Inhibitory effects of a gonadotropin-releasing hormone agonist on the luteal synthesis of progesterone, estradiol receptors, and prolactin surges during early pregnancy. Endocrinology 1988; 123(-4-):1740-1746. >>> Luteinizing HRH agonist; Wy-40972; SC; rat (pregnant); 2001; peptides.

1322 Hyland, J.H., Jeffcott, L.B. Control of transitional anestrus in mares by infusion of gonadotropin releasing hormone. Theriogenology 1988; 29(-6-):1383-1391. >>> Luteinizing HRH; Saline; SC; horse; 2ML4; peptides.

1294 Ataya, K., Weintraub, A., Dunbar, J., Zimniski, S., Puett, D., LeMaire, W. Effect of luteinizing hormone releasing hormone (LHRH) agonists on body weight in rats. Drug Dev. Res 1988; 13(--):45-56. >>> Luteinizing HRH; Saline; SC; rat; 2ML4; dose-response (graph); comparison of sc injections vs. mp infusion; peptides.

1258 Lalloz, M.R.A., Detta, A., Clayton, R.N. Gonadotropin-releasing hormone is required for enhanced luteinizing hormone subunit gene expression in vivo. Endocrinology 1988; 122(-4-):1681-1688. >>> Luteinizing HRH antagonist; Albumin, bovine serum; DMSO; PBS; IP; rat; pump model not stated.

1257 Lalloz, M.R.A., Detta, A., Clayton, R.N. Gonadotropin-releasing hormone desensitization preferentially inhibits expression of the lutenizing hormone B-subunit gene in vivo. Endocrinology 1988; 122(-4-):1689-1694. >>> Buserelin; Luteinizing HRH; Albumin, bovine serum; PBS; IP; rat; pump model not stated; buserelin infused for 28 days; agents infused separately; functionality of mp verified; pump replaced after 2 weeks; peptides.

1248 Schuilling, G.A., Pols-Valkhof, N., Koiter, T.R. Long-lasting negative effect of oestradiol benzoate on the LH-Rh-induced secretion of LH and FSH: role of LH-RH. IRCS Med. Sci 1983; 11(-10-):885-886. >>> Luteinizing HRH; SC; rat; 2001; controls received sham pump the size of mp; OB and/or oil administered concomitantly w/ LHRH; peptides.

1238 Milette, J.J., Schwartz, N.B., Turek, F.W. The importance of follicle-stimulating hormone in the initiation of testicular growth in photostimulated djungarian hamsters. Endocrinology 1988; 122(--):1060-1066. >>> Follicle stimulating hormone, ovine; Luteinizing hormone; Saline; IP; hamster; 2001; controls left untreated; dose-response (graph); peptides; ovine LH used.

1231 Folkers, K., Humphries, J., Bowers, C.Y. Evolution of design and achievement of inhibitors of the luteinizing hormone-releasing hormone as inhibitors of ovulation. Z. Naturforsch 1982; 37(-2-):246-259. >>> Luteinizing HRH analog; Propylene glycol; SC; rat; pump model not stated; vague mention of mp.

1197 Sundaram, K., Keizer-Zucker, A., Thau, R.B., Bardin, C.W. Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys. J. Androl 1987; 8(-2-):103-107. >>> Luteinizing HRH agonist; Water; SC; monkey; 2ML4; supplemental androgen therapy; long-term study; pump replaced at 4 week intervals.

1193 Mann, D.R., Collins, D.C., Smith, M.M., Gould, K.G. Effect of continuous infusion of a low dose of GnRH antagonist on serum LH and testosterone concentrations, spermatogenesis and semen quality in the rhesus monkey (Macaca mulatta). J. Reprod. Fertil 1987; 81(--):485-493. >>> Luteinizing HRH antagonist; SC; monkey; 2ML4; iv bolus of GnRH given at monthly intervals; long-term study; pump replaced every 4 weeks; peptides.

1189 Lamming, G.E., McLeod, B.J. Continuous infusion of GnRH reduces the LH response to an intravenous GnRH injection but does not inhibit endogenous LH secretion in cows. J. Reprod. Fertil 1989; 82(--):237-245. >>> Luteinizing HRH; Saline; SC; cattle; 2ML2; pump primed 10 hours before implant; bolus iv injections given the day before and 14th day of GnRH infusion; functionality of mp verified by incubation in vitro for 15 hours after removal; peptides.

15397 Marte, C.L., Sherwood, N.M., Harvey, B. Induced spawning of maturing milkfish (chanos chanos forsskal) with gonadotropin-releasing hormone (GnRH) analogues administered in various ways. Aquaculture 1987; 60(-3/4-):303-310. >>> Luteinizing HRH; HCl; IP; fish; 2002; mp primed 12 hrs. at 4 degrees C; concomitant infusion; comparison of im inject. vs. LHRH pellet vs. mp infusion; functionality of mp verified; stress/adverse reaction (tissue necrosis); peptides; salmon&mammal LHRH used.

1141 Marte, C.L., Sherwood, N.M., Harvey, B. Induced spawning of maturing milkfish (chanos chanos forsskal) with gonadotropin-releasing hormone (GnRH) analogues administered in various ways. Aquaculture 1987; 60(-3/4-):303-310. >>> Luteinizing HRH; HCl; IP; fish; 2002; mp primed 12 hrs. at 4 degrees C; concomitant infusion; comparison of im inject. vs. LHRH pellet vs. mp infusion; functionality of mp verified; stress/adverse reaction (tissue necrosis); peptides; salmon&mammal LHRH used.

15390 Hyland, J.H., Wright, P.J., Clarke, I.J., Carson, R.S., Langsford, D.A., Jeffcott, L.B. Infusion of gonadotrophin-releasing hormone (GnRH) induces ovulation and fertile oestrus in mares during seasonal anoestrus. J. Reprod. Fertil 1987; 35(--):211-220. >>> Luteinizing HRH; Saline; SC; horse; 2ML4; controls remained untreated; dose-response; infusion of GnRH via mp did not produce linear plasma increaes, possibly because of stability of GnRH in solution or pooling at implant site; peptides.

1134 Hyland, J.H., Wright, P.J., Clarke, I.J., Carson, R.S., Langsford, D.A., Jeffcott, L.B. Infusion of gonadotrophin-releasing hormone (GnRH) induces ovulation and fertile oestrus in mares during seasonal anoestrus. J. Reprod. Fertil 1987; 35(--):211-220. >>> Luteinizing HRH; Saline; SC; horse; 2ML4; controls remained untreated; dose-response; infusion of GnRH via mp did not produce linear plasma increaes, possibly because of stability of GnRH in solution or pooling at implant site; peptides.

15387 Kesler, D.J., Cruz, L.C., McKenzie, J.A. Constant delivery of GnRH to infertile or subfertile females with hypothalamic-pituitary axes that release hormones in episodic bursts. Proc. 14th Int'l Symp. on Controlled Release of Bioactive Materials 1987; (--):47-48. >>> Luteinizing HRH; Potassium phosphate; SC; horse; 2001; controls receive mp w/ vehicle; dose-response; mp primed 4 hours before implant; 2 experiments using mp; progestrin silastic implants used concomitantly with GnRH; peptides.

1131 Kesler, D.J., Cruz, L.C., McKenzie, J.A. Constant delivery of GnRH to infertile or subfertile females with hypothalamic-pituitary axes that release hormones in episodic bursts. Proc. 14th Int'l Symp. on Controlled Release of Bioactive Materials 1987; (--):47-48. >>> Luteinizing HRH; Potassium phosphate; SC; horse; 2001; controls receive mp w/ vehicle; dose-response; mp primed 4 hours before implant; 2 experiments using mp; progestrin silastic implants used concomitantly with GnRH; peptides.

1060 Huhtaniemi, I.T., Nikula, H., Detta, A., Stewart, J.M., Clayton, R.N. Blockade of rat testicular gonadotropin releasing hormone (GnRH) receptors by infusion of a GnRH antagonist has no major effects on Leydig cell function in vivo. Mol. Cell. Endocrinol 1987; 49(--):89-97. >>> Luteinizing HRH antagonist; DMSO; Saline; intratesticular; rat; 2001; 2002; controls received cannula without mp; mp connected to cannula buried in the testis; functionality of mp verified by measuring vol. of fluid left in mp; tissue perfusion (testis); peptides.

1048 Phillips, J.A., Frye, F., Bercovitz, A., Calle, P., Millar, R., Rivier, J., Lasley, B.L. Exogenous GnRH overrides the endogenous annual reproductive rhythm in green iguanas, iguana iguana. J. Exp. Zool 1987; 241(--):227-236. >>> Luteinizing HRH; Peanut oil; IP; iguana; 2ML2; controls received mp w/vehicle; peptides; pumps primed in saline before implantation; pulsed delivery; chicken&mammal LHRH used.

1046 Greenstein, B.D., Fitzpatrick, F.T.A., Kendall, M.D., Wheeler, M.J. Regeneration of the thymus in old male rats treated with a stable analogue of LHRH. J. Endocrinol 1987; 112(--):345-350. >>> Luteinizing HRH analog; Citrate; SC; rat; 2ML4; controls received mp w/vehicle; peptides.

1034 Adams, T.E., Cumming, S., Adams, B.M. Gonadotropin-releasing hormone (GnRH) receptor dynamics and gonadotrope responsiveness during and after continuous GnRH stimulation. Biol. Reprod 1986; 35(--):881-889. >>> Luteinizing HRH; Saline; IP; rat; 2001; peptides; comparison of iv injections vs. mp infusion.

1010 Schuiling, G.A., Moes, H., Koiter, T.R. Effect of clomiphene citrate on the in vitro release of LH and FSH by the pituitary gland of the long-term ovariectomized rat pretreated with LRH or with LRH and oestradiol benzoate. Acta Endocrinol 1986; 113(--):35-41. >>> Luteinizing HRH; SC; rat; 2001; controls received mp sized silicone elastomer; peptides.

1007 Schuiling, G.A., Moes, H., de Koning, J., Koiter, T.R. Suppression by LRH of the stimulatory effect of oestradiol on the secretion of LH by the rat pituitary gland. Acta Endocrinol 1987; 114(--):488-496. >>> Luteinizing HRH; SC; rat; 2001; controls received silicone elastomer the size of mp; peptides.

1006 Weinbauer, G.F., Surmann, F.J., Nieschlag, E. Suppression of spermatogenesis in a nonhuman primate (macaca fascicularis) by concomitant gonadotropin-releasing hormone antagonist and testosterone treatment. Acta Endocrinol 1987; 114(--):138-146. >>> Luteinizing HRH antagonist; Propylene glycol; Water; SC; monkey; 2002; 2ML1; mp w/vehicle; pumps replaced every 16 days; peptides; 4 pumps/animal until last wk when 1-week pump was implanted; functionality of mp verified by comp. volume left in pump after removal; long-term study.

992 Asher, G.W., MacMillan, K.L. Induction of oestrus and ovulation in anoestrous fallow deer (Dama dama) by using progesterone and GnRH treatment. J. Reprod. Fertil 1986; 78(--):693-697. >>> Luteinizing HRH; Albumin, bovine serum; Saline; SC; deer; 2001; 2001, 7 days; 2 doses of agent infused; peptides.

907 Schuiling, G.A., Pols-Valkhof, N., Koiter, T.R. Clomiphene citrate can mimic the augmentative (positive) but not the depressing (negative) effect of estradiol on the LHRH-stimulated release of LH and FSH by the pituitary gland of the long-term ovariectomized rat. Experientia 1985; 41(-8-):1060-1063. >>> Luteinizing HRH; SC; rat; 2001; controls received silastic sham pump; peptides.

902 Ruiz de Elvira, M.C., Abbott, D.H. A backpack system for long-term osmotic minipump infusions into unrestrained marmoset monkeys. Lab. Anim 1986; 20(--):329-334. >>> Luteinizing HRH; SC; monkey; 2001; mp conn. to cannula, external pump application; pumps replaced every 10 days; mp cont. in saline filled vial attached to backpack; sys. used for long-term inf. up to 3 mths; pulsed delivery of LHRH using backpack system; peptides.

867 Skaggs, C.L., Able, B.V., Stevenson, J.S. Pulsatile or continuous infusion of luteinizing hormone-releasing hormone and hormonal concentrations in prepubertal beef heifers. J. Anim. Sci 1986; 62(--):1034-1048. >>> Luteinizing HRH; Saline; SC; cattle; 2ML1; controls were untreated; dose-response; half-life data for FSH; comparison of ip injections vs. mp infusion; peptides.

843 Lindburg, D., Millard, S., Lasley, B. Induced estrus in the cheetah. Ann. Proc. AAZPA 1985; (--):560-563. >>> Luteinizing HRH; SC; cat (cheetah); mp model not stated; pulsed delivery of GnRH to induce estrus; peptides.

839 Huhtaniemi, I.T., Stewart, J.M., Channabasavaiah, K., Fraser, H.M., Clayton, R.N. Effect of treatment with GnRH antagonist, GnRH antiserum and bromocriptine on pituitary-testicular function of adult rats. Mol. Cell. Endocrinol 1984; 34(--):127-135. >>> Luteinizing HRH antagonist analog; DMSO; IP; rat; controls were sham operated; in one study mp infusion was combined w/bromocriptine treatment; one group treated w/LHRH antiserum; peptides.

837 Huhtaniemi, I., Nikula, H., Rannikko, S., Clayton, R. Regulation of testicular steroidogenesis by gonadotropin-releasing hormone agonists and antagonists. J. Steroid Biochem 1986; 24(-1-):169-176. >>> Luteinizing HRH antagonist; DMSO; Saline; intratesticular; IP; rat; mp conn. to polystyrene cannula imbedded in testis in one exp.; bromocriptine admin. concomitantly w/mp infusion; treatment w/ GnRH antiserum vs. mp infusion of antagonist; controls received mp w/vehicle or piece of tubing similar to mp; peptides; tissue.

800 Sridaran, R  Proc. Soc. Exp. Biol. Med 1986; 182(--):120-126. >>> Luteinizing HRH; Wy-40972; SC; rat (pregnant); 2002; mps primed in saline overnight; controls received sham surgery only; dose-response (plasma hormone levels); peptides.

789 Krishna, A., Terranova, P.F., Matteri, R.L., Papkoff, H. Histamine and increased ovarian blood flow mediate LH-induced superovulation in the cyclic hamster. J. Reprod. Fertil 1986; 76(-1-):23-29. >>> Fluoromethylhistidine, a-; Luteinizing hormone; Albumin, bovine serum; PBS; SC; hamster; 2001; Multiple pumps per animal (2) in some groups-one pump per agent; comparison of fluromethylhistidine or cimetidine injections vs. mp infusion; peptides; ovine LH used.

761 Lasley, B.L., Wing, A. Stimulating ovarian function in exotic carnivores with pulses of GnRH. Presented at the Annual Meeting of the American Association of Zoo Veterinarians, Oct. 24-27, Tampa, FL 1983; (--):14-15. >>> Luteinizing HRH; SC; cat (cheetah); cat (golden cat); cat (leopard); 2ML2; 2ML4; pulsed delivery of LHRH and peanut oil; mp primed in saline for 8 hrs. prior to implant; peptides; stress/adverse reaction (fibrous tissue adhering to silastic coils connected to mp in the golden cat).

703 Schuiling, G.A., Moes, H., Koiter, T.R. The depressing (negative) effect of oestradiol benzoate on the in vitro secretion of LH and FSH by the pituitary gland of the LRH-pretreated long-term ovariectomized rat changes into the augmentative (positive) effect after discontinuation of the LRH-pret. Acta Endocrinol 1985; 110(--):329-337. >>> Luteinizing HRH; Saline; SC; rat; 2001; controls received sham pumps w/ estradiol or oil; peptides.

701 Phillips, J.A., Alexander, N., Karesh, W.B., Millar, R., Lasley, B.L. Stimulating male sexual behavior with repetitive pulses of GnRH in female green iguanas, Iguana iguana. J. Exp. Zool 1985; 234(-3-):481-484. >>> Luteinizing HRH; Acetic acid; IP; iguana; 2ML2; no stress (see pg. 483); pulsed delivery of LHRH (intermittent w/peanut oil); mp primed in saline prior to implant; peptides; chicken LHRH used.

686 Wing, T.-Y., Ewing, L.L., Zegeye, B., Zirkin, B.R. Restoration effects of exogenous luteinizing hormone on the testicular steroidogenesis and Leydig cell ultrastructure. Endocrinology 1985; 117(-5-):1779-1787. >>> Luteinizing hormone; Borate; intratesticular; rat; 2001; Pump primed in saline; peptides; tissue perfusion; ovine LH used.

672 Rousey, S., Terranova, P.F. Elevated peripheral concentrations of LH block ovulation and increase thecal and serum progesterone in the hamster. J. Reprod. Fertil 1985; 74(-1-):197-203. >>> Luteinizing hormone; Albumin, bovine serum; PBS; SC; hamster; 2001; some hamsters also received ip hCG; peptides; ovine LH used.

555 Schuiling, G.A., Pols-Valkhof, N., van der Schaaf-Verdonk, G.C.J., Koiter, T.R. Blockade of LH and FSH secretion by LH-releasing hormone, by the LH-releasing hormone analogue, buserelin, and by combined treatment with LH-releasing hormone and oestradiol benzoate. J. Endocrinol 1984; 103(-3-):301-309. >>> Buserelin; Luteinizing HRH; SC; rat; 2001; replacement therapy (ovariectomy); controls received sham pump; peptides.

520 Garza, F., Shaban, M.A., Terranova, P.F. Luteinizing hormone increases the number of ova shed in the cyclic hamster and guinea-pig. J. Endocrinol 1984; 101(--):289-298. >>> Gonadotrophin, pregnant mare serum; Luteinizing hormone; Follicle stimulating hormone, ovine; Gonadotrophin, human chorionic; Albumin, bovine serum; PBS; SC; guinea-pig; hamster; mice; rat; 2001; comparison of agents effects; replacement therapy (hypophysectomy); agents admin. singly; peptides; bovine, ovine,&human LH used.

506 Schuiling, G.A., Moes, H., Koiter, T.R. Desensitization of the pituitary gland induced in vivo by luteinizing hormone-releasing hormone (LRH) or by the LRH-analogue buserelin does not affect the autonomous secretion of luteinizing hormone and follicle stimulating hormone as observed in vitro. Acta Endocrinol 1984; 106(--):454-458. >>> Buserelin; Luteinizing HRH; SC; rat; 2001; comparison of agents effects; silastic sham pump used as control; states release rate of mp as 0.1 ul/hr in error; peptides.

478 Schuiling, G.A., Moes, H., Koiter, T.R. Prolonged combined in vivo pre-treatment with luteinizing hormone-releasing hormone (LRH) and oestradiol benzoate causes long-lasting suppression of the autonomous and the LRH-stimulated secretion of luteinizing hormone and follicle stimulating hormone. Acta Endocrinol 1984; 105(--):468-473. >>> Luteinizing HRH; SC; rat; 2001; controls received a sham-pump (a piece of silastic with minipump dimensions); concurrect admin. of estradiol; peptides.

474 Garza, F., Terranova, P.F. Inhibition of thecal androstenedione production by exogenous progesterone in the cyclic hamster. J. Reprod. Fertil 1984; 70(-2-):493-498. >>> Luteinizing hormone; Albumin, bovine serum; PBS; SC; hamster; 2001; concomitant continuous progesterone deliv. by silastic implant reduced normal LH levels; peptides; ovine LH used.

340 Wright, P.J., Clarke, I.J., Findlay, J.K. The induction of fertile oestrus in seasonally anoestrous ewes using a continuous low dose administration of gonadotrophin releasing hormone. Aust. Vet. J 1983; 60(-8-):254-255. >>> Luteinizing HRH; SC; sheep; 2001; ewes were pretreated w/ 3 progesterone-containing Sil-Estrus implants; peptides.

322 Ewing, L.L., Wing, T.-Y., Cochran, R.C., Kromann, N., Zirkin, B.R. Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 1983; 112(-5-):1763-1769. >>> Follicle stimulating hormone; Growth hormone, ovine; Luteinizing hormone; Prolactin, ovine; Thyroid-stimulating hormone; Borate; Peanut oil; SC; rat; replacement therapy (hypophysectomy); simultaneous infusion of testosterone&estradiol implants w/ mp infusion of polypeptides; pulsed delivery of agents (intermittent w/ vehicle); peptides; ovine LH used.

221 Clayton, R.N. Gonadotropin-releasing hormone modulation of its own pituitary receptors: evidence for biphasic regulation. Endocrinology 1982; 111(-1-):152-161. >>> Luteinizing HRH; Luteinizing HRH analog; Albumin, bovine serum; Saline; IP; rat; peptides.

15311 Murphy, B.D., Humphrey, W.D., Shepstone, S.L. Luteal function in mink: the effects of hypophysectomy after the preimplantation rise in progesterone. Anim. Reprod. Sci 1980; 3(--):225-232. >>> Luteinizing hormone; Prolactin, bovine; Saline; IP; mink; organ replacement therapy (hypophysectomy); peptides; ovine LH used.

71 Murphy, B.D., Humphrey, W.D., Shepstone, S.L. Luteal function in mink: the effects of hypophysectomy after the preimplantation rise in progesterone. Anim. Reprod. Sci 1980; 3(--):225-232. >>> Luteinizing hormone; Prolactin, bovine; Saline; IP; mink; organ replacement therapy (hypophysectomy); peptides; ovine LH used.

15306 Harwood, J.P., Clayton, R.N., Chen, T.T., Knox, G., Catt, K.J. Ovarian gonadotropin-releasing hormone receptors. II. Regulation and effects on ovarian development. Endocrinology 1980; 107(-2-):414-421. >>> Luteinizing HRH; Luteinizing HRH antagonist analog; IP; rat; organ replacement therapy (hypophysectomy); peptides.

64 Harwood, J.P., Clayton, R.N., Chen, T.T., Knox, G., Catt, K.J. Ovarian gonadotropin-releasing hormone receptors. II. Regulation and effects on ovarian development. Endocrinology 1980; 107(-2-):414-421. >>> Luteinizing HRH; Luteinizing HRH antagonist analog; IP; rat; organ replacement therapy (hypophysectomy); peptides.

35 Hagino, N., Nakamoto, O., Kunz, Y., Arimura, A., Coy, D.H., Schally, A.V. Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon. Acta Endocrinol 1979; 91(-2-):217-223. >>> Luteinizing HRH agonist; Saline; SC; Monkey (baboon); peptides.

29 Amundson, B.C., Wheaton, J.E. Effects of chronic LHRH treatment on brain LHRH content, pituitary and plasma LH and ovarian follicular activity in the anestrous ewe. Biol. Reprod 1979; 20(--):633-638. >>> Luteinizing HRH; Saline; SC; sheep; pumps replaced each week; peptides.

28 Yoshinaga, K. Suppression of ovarian function by LHRH and its analogues in pregnant rats. In'Ovarian Follicular and Corpus Luteum Function,'C. P. Channing, J. Marsh, and W. S. Sadler, (eds. ), Plenum Pub. Corp. , New York 1979; (--):729-734. >>> Luteinizing hormone; Luteinizing HRH; Luteinizing HRH analog; SC; rat; peptides; ovine LH used.

15302 Arimura, A., Pedroza, E., Vilchez-Martinez, J., Schally, A.V. Prevention of implantation by D-Trp6-LH-RH in the rat: comparative study with the effects of large doses of HCG on pregnancy. Endocrinol. Res. Commun 1977; 4(-6-):357-366. >>> Luteinizing HRH, D-Trp6-;; Saline; Acetic acid;; SC;; rat (pregnant);; Teratology.

6 Arimura, A., Pedroza, E., Vilchez-Martinez, J., Schally, A.V. Prevention of implantation by D-Trp6-LH-RH in the rat: comparative study with the effects of large doses of HCG on pregnancy. Endocrinol. Res. Commun 1977; 4(-6-):357-366. >>> Luteinizing HRH, D-Trp6-;; Saline; Acetic acid;; SC;; rat (pregnant);; Teratology.

15293 Bowers, C.Y., Folkers, K. Contraception and inhibition of ovulation by minipump infusion of the luteinizing hormone releasing hormone, active analogs and antagonists. Biochem. Biophys. Res. Commun 1976; 72(-3-):1003-1007. >>> Luteinizing HRH; Propylene glycol; SC; Rat; peptides; replacement therapy (castration).

3 Bowers, C.Y., Folkers, K. Contraception and inhibition of ovulation by minipump infusion of the luteinizing hormone releasing hormone, active analogs and antagonists. Biochem. Biophys. Res. Commun 1976; 72(-3-):1003-1007. >>> Luteinizing HRH; Propylene glycol; SC; Rat; peptides; replacement therapy (castration).

 

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“All the rats survived for the length of the experiments. The intratracheal pump was well tolerated and the procedure produced no overt complications.” (p. 123) Svetlecic et al., Lung 2004;182:119-134.