Long-Term Infusion Using ALZET® Osmotic Pumps

16292 Clancy, M. M., Newton, A. L., Sykes, J. M. Management of Osteomyelitis Caused by Salmonella Enterica Subsp. Houtenae in a Taylor's Cantil (Agkistrodon Bilineatus Taylori) Using Amikacin Delivered Via Osmotic Pump. J Zoo Wildl Med 2016; 47(-2-):691-4. >>> Amikacin; SC; snake; 2002; animal info (adult female Taylor’s cantil, 6 yr old); good methods; spinal cord injury; long-term study; “This study demonstrates that the infection can be suppressed and the animal’s life extended by long-term continuous infusion of amikacin and that such treatment did not result in renal compromise in this individual.” pg 694; Veterinary Application; temperature adjusted pumping rate for snake; Industry authored (American Association of Zoo Veterinarians); Interesting (Veterinary use presented for treating animal with antibiotics for extended duration; minimizing need for animal handling); Dose (26ug/kg/hr);.

16190 Iwasaki, Y., Kazama, J. J., Yamato, H., Matsugaki, A., Nakano, T., Fukagawa, M. Altered material properties are responsible for bone fragility in rats with chronic kidney injury. Bone 2015; 81(--):247-54. >>> Parathyroid hormone, rat; SC; rat; 2002; Controls received sham operation; animal info: 12-week-old male Sprague-Dawley; functionality of mp verified by urine samples; pumps replaced every 2 weeks; pumps replaced every 2 weeks; long-term study; Dose: 0.1Ǩg/kg/h.

16130 Gopal, K., Gowtham, M., Sachin, S., Ravishankar Ram, M., Shankar, E. M., Kamarul, T. Attrition of Hepatic Damage Inflicted by Angiotensin II with alpha-Tocopherol and beta-Carotene in Experimental Apolipoprotein E Knock-out Mice. Sci Rep 2015; 5(--):18300. >>> Angiotensin II; Saline; SC; mice; Controls received mp w/ vehicle; animal info: Apoe−/− mice; long-term study; peptides; found that liver damage was induced by Ang II; Dose: 1.44 mg/kg/day; 50Ǩg/30 gm.

16092 Appleton, C. T., Usmani, S. E., Pest, M. A., Pitelka, V., Mort, J. S., Beier, F. Reduction in disease progression by inhibition of transforming growth factor alpha-CCL2 signaling in experimental posttraumatic osteoarthritis. Arthritis Rheumatol 2015; 67(-10-):2691-701. >>> AG1478; RS504393; DMSO; water, deionized; SC; rat; 2ML4; Controls received mp w/ vehicle; functionality of mp verified by plasma levels and knee articular cartilage; pumps replaced every 4 weeks; %50 of DMSO; long-term study; enzyme inhibitor (EGFR and CCR2 inhibitors); EGFR inhibitor AG1478, CCR2 inhibitor RS504393; Dose: (AG1478) 21 nmoles/kg/hour; (RS504393) 200 nmoles/kg/hour.

16084 Zhao, L., Zhuang, J., Xu, F. Bronchopulmonary C-fibers'IL1RI contributes to the prolonged apneic response to intra-atrial injection of capsaicin by prenatal nicotinic exposure in rat pups. Toxicol Appl Pharmacol 2016; 303(--):58-64. >>> Nicotine; methyllycaconitine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced every 28 days; Multiple pumps per animal (2); long-term study; teratology; MLA is an a7nAChR antagonist; methyllycaconitine aka MLA; Dose (nicotine 6 mg/kg/day; MLA 3 mg/kg/day);.

16074 Yang, J., Chen, Y. N., Xu, Z. X., Mou, Y., Zheng, L. R. Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. Cell Physiol Biochem 2016; 39(-1-):229-41. >>> Alendronate; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, spontaneously hypertensive rat or Wistam-Kyoto, 6 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; enzyme inhibitor (farnesyl pyrophosphate synthase); bp measured using tail cuff; Dose (100 ug/kg/day);.

16069 Xiaojun, W., Yan, L., Hong, X., Xianghong, Z., Shifeng, L., Dingjie, X., Xuemin, G., Lijuan, Z., Bonan, Z., Zhongqiu, W., Ruimin, W., Brann, D., Fang, Y. Acetylated alpha-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica. Sci Rep 2016; 6(--):32257. >>> Ac-SDKP; Saline; IP; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Wistar, 3 weeks old, 180g); long-term study; peptides; Dose (800 ug/kg/day);.

15997 Uli S. Herrmann,, Anne K. Schütz,, Hamid Shirani,, Danzhi Huang,, Dino Saban, Mario Nuvolone,, Bei Li,, Boris Ballmer,, Andreas K. O.Åslund,, Jeffrey J. Mason,, Elisabeth Rushing,, Herbert Budka,, Sofie Nyström,, Per Hammarström,, Anja Böckmann,, Amedeo Caflisch,, Beat H. Meier,, K. Peter R. Nilsson,, Simone Hornemann,, Adriano Aguzzi  Science Translational Medicine 2015; 7(-299-):1-18. >>> LIN1001l; LIN5001; LIN5002; LIN7002; PBS; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (WT CD1 or PrP-overexpressing mice); pumps replaced every 42 days; post op. care (Finadyne 2.5 mg/kg BID SC; Temgesic SC injection 0.1 mg/kg; Borgal 2ml 24% in drinking water); post op. care (Finadyne 2.5 mg/kg BID SC; Temgesic SC injection 0.1 mg/kg; Borgal 2ml 24% in drinking water); long-term study; Dose (3.3 mg/kg/week); brain coordinates;.

15970 Lataro, R. M., Silva, C. A., Tefe-Silva, C., Prado, C. M., Salgado, H. C. Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. Am J Hypertens 2015; 28(-10-):1201-8. >>> Pyridostigmine bromide; donepezil; SC; Rat; 2004; animal info (male, Wistar-Kyoto or SHR); pumps replaced every 4 weeks; long-term study; cardiovascular; bp measured using tail cuff; Dose (Pyridostigmine bromide 1.5 mg/kg/day; donepezil 1.4 mg/kg/day);.

15893 Vieira, F. G., Ping, Q., Moreno, A. J., Kidd, J. D., Thompson, K., Jiang, B., Lincecum, J. M., Wang, M. Z., De Zutter, G. S., Tassinari, V. R., Levine, B., Hatzipetros, T., Gill, A., Perrin, S. Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLoS One 2015; 10(-8-):e0135570. >>> Guanabenz acetate; Ethanol; water; propylene glycol; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (SOD1-G93A); pumps replaced every 28 days; dose-response (pg 4); neurodegenerative (amyotrophic lateral sclerosis); post op. care (antibiotic ointment; buprenorphine 0.1 mg/kg); long-term study; used lot#10284-12; Dose (0.45, 1.5, or 4.5 mg/kg/day);.

15851 Yamada, C., Kuwahara, K., Yamazaki, M., Nakagawa, Y., Nishikimi, T., Kinoshita, H., Kuwabara, Y., Minami, T., Yamada, Y., Shibata, J., Nakao, K., Cho, K., Arai, Y., Honjo, H., Kamiya, K., Nakao, K., Kimura, T. The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy. Cardiovasc Res 2016; 109(-1-):162-73. >>> Aliskiren; SC; Mice; Controls received mp w/ vehicle; animal info (male, dnNRSF-Tg, 16 weeks old); long-term study; cardiovascular; Dose (23 mg/kg/day);.

15819 Analyne M. Schroeder, Huei Bin Wang, Saemi Park, Maria C. Jordan, Fuying Gao, Giovanni Coppola, Michael C. Fishbein, Kenneth P. Roos, Cristina A. Ghiani, Christopher S. Colwell  PLoS One 2016; 11(-1-):1-25. >>> Isoproterenol; Saline; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (BACHD or WT, 2-3 months old); neurodegenerative (Huntington's Disease); long-term study; cardiovascular; Dose (0.24, 0.48, 0.97 mg/day);.

15796 Dusan Matusica, Fabienne Alfonsi, Bradley J. Turner, Tim J. Butler, Stephanie R. Shepheard, Mary-Louise Rogers, Sune Skeldal, Clare K. Underwood, Marie Mangelsdorf, Elizabeth J. Coulson  Journal of Cell Science 2016; 129(--):517-530. >>> Peptide, c29; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (SOD G93A, 9 weeks old); pumps replaced every month until death; neurodegenerative (amyotrophic lateral sclerosis); neurodegenerative (amyotrophic lateral sclerosis); long-term study; peptides; Dose (5 mg/kg/day);.

15758 Daniel G. Donner,, Grace E. Elliott,, Belinda R. Beck,, Andrew C. Bulmer,, Alfred K. Lam,, John P. Headrick,, and Eugene F. Du Toit  Endocrinology 2016; 157(-1-):368-381. >>> Testosterone; trenbolone; Cyclodextrin, 2b-hydroxypropyl; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 12 weeks old, 300g); functionality of mp verified by plasma; pumps replaced every 4 weeks; 45% cyclodextrin used; ischemia (cardiac); post op. care (buprenorphine 10 ug/kg/day IM; enrofloxacin 5 mg/kg ip for 3 days); long-term study; Dose (2 mg/kg/day);.

15724 Sara K.S. Bengtsson,, Maja Johansson,, Torbjörn Bäckström  Horm. Behav 2016; (-78-):160-167. >>> Allopregnanolone; Captisol; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J); pumps replaced every month; 60% Captisol used; post op. care (Carprofen); behavioral testing (Morris water maze); long-term study; Industry authored (Umecrine Cognition AB);.

15252 Owens, P., Pickup, M.W., Novitskiy, S.V., Giltnane, J.M., Gorska, A.E., Hopkins, C.R., Hong, C.C., Moses, H.L., Owens, P. Inhibition of BMP signaling suppresses metastasis in mammary cancer. ONCOGENE 2015; 34(--):2437-2449. >>> DMH1; DMSO; Saline; Mice; 2006; Controls received mp w/ vehicle; animal info (female, MMTV.PyVMT, 7 weeks old); cancer (breast); DMH1 is a BMP (bone morphogenic protein) antagonist; long-term study;.

15179 Zhao, J.Z., Liu, C.Q., Bai, Y.T., Wang, T.Y., Kan, H.D., Sun, Q.H., Sun, Q.H. IKK inhibition prevents PM(2.5)-exacerbated cardiac injury in mice with type 2 diabetes. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 2015; 31(--):98-103. >>> IMD-0354; DMSO; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (KKay, 7 weeks old); long-term study; cardiovascular; immunology; diabetes; used Plastics One Cannula;.

15172 Zhang, X., Thatcher, S., Wu, C.Q., Daugherty, A., Cassis, L.A., Cassis, L.A. Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms. JOURNAL OF VASCULAR SURGERY 2015; 61(--):767-776. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, ApoE -/-, 2 months old, orchiectomy); pumps replaced every month; long-term study; cardiovascular; peptides;.

15150 Yan, J.G., Logiudice, J., Davis, J., Zhang, L.L., Agresti, M., Sanger, J., Matloub, H.S., Havlik, R., Yan, J.G. CALCITONIN PUMP IMPROVES NERVE REGENERATION AFTER TRANSECTION INJURY AND REPAIR. MUSCLE&NERVE 2015; 51(--):229-234. >>> Calcitonin; Water, distilled sterile; CSF/CNS (sciatic nerve); Rat; 2006; Animal info (Sprague Dawley, 250-300g, 3 months old); half-life (p.233); long-term study;“To achieve a continuous and gradual mode of delivery, a mini-osmotic pump was implanted to deliver medication at a constant 0.15 ul/h” pg 233;"Calcitonin has short absorption and elimination half-lives of 10–15 minutes and 50–80 minutes, respectively; however, using an osmotic pump allows for gradual and prolonged release."pg233; pg230 diagram of pump implantation;.

15256 Wu, Y., Song, P., Zhang, W.C., Liu, J.H., Dai, X.Y., Liu, Z.Y., Lu, Q.L., Ouyang, C.H., Xie, Z.L., Zhao, Z.X., Zhuo, X.Z., Viollet, B., Foretz, M., Wu, J.L., Yuan, Z.Y., Zou, M.H., Zou, M.H. Activation of AMPKalpha2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. NATURE MEDICINE 2015; 21(--):373-+. >>> Nicotine; Saline; SC; Mice; rat; Controls received mp w/ vehicle; animal info (mice male, C57BL6J, 8 weeks old; rat male, Sprague Dawley, 10 weeks old); diabetes; long-term study;.

15254 Wheelan, N., Webster, S.P., Kenyon, C.J., Caughey, S., Walker, B.R., Holmes, M.C., Seckl, J.R., Yau, J.L.W., Yau, J.L.W. Short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice. NEUROPHARMACOLOGY 2015; 91(--):71-76. >>> UE2316; DMSO; PEG; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6J, 24 months old); pumps replaced every 21 days with opposite treatment (drug replaced with vehicle, etc.); 50% DMSO used; 50% PEG used; behavioral testing (spatial memory y-maze; contextual fear conditioning); long-term study;.

15131 Wang, M.Y., Yan, H., Shi, Z.Q., Evans, M.R., Yu, X.X., Lee, Y., Chen, S., Williams, A., Philippe, J., Roth, M.G., Unger, R.H., Roth, M.G. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):2503-2508. >>> Leptin, recombinant; pramlintide acetate; liraglutide; exenatide; SC; Mice (NOD); 2001; Controls received mp w/ PBS; animal info (female, NOD/ShiLtJ, 8 weeks old); pumps replaced every 7 days; long-term study; diabetes;.

15253 Vu, B.G., Stach, C.S., Kulhankova, K., Salgado-Pabon, W., Klingelhutz, A.J., Schlievert, P.M., Schlievert, P.M. Chronic Superantigen Exposure Induces Systemic Inflammation, Elevated Bloodstream Endotoxin, and Abnormal Glucose Tolerance in Rabbits: Possible Role in Diabetes. MBIO 2015; 6(--):U999-U1008. >>> Toxic shock syndrome toxin-1; SC; Rabbit; 2006; Controls received mp w/ PBS; animal info (New Zealand White); immunology; diabetes; Toxic shock syndrome toxin-1 aka TSST-1; long-term study;.

15112 Thomas, N.P., Li, P.C., Fleming, B.C., Chen, Q., Wei, X.C., Pan, X.H., Li, G., Wei, L., Wei, L. Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100. JOURNAL OF ORTHOPAEDIC RESEARCH 2015; 33(--):1071-1078. >>> AMD3100; SC; Mice; 1004; Controls received mp w/ PBS or empty pumps; animal info (male, C57BL6J, 2 months old); pumps replaced every 4 weeks; long-term study;.

15104 Thakker, D.R., Sankaranarayanan, S., Weatherspoon, M.R., Harrison, J., Pierdomenico, M., Heisel, J.M., Thompson, L.A., Haskell, R., Grace, J.E., Taylor, S.J., Albright, C.F., Shafer, L.L., Shafer, L.L. Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. JOURNAL OF NEUROSCIENCE 2015; 35(--):6931-6936. >>> Compound c; PBS; DMSO; PEG 300; SC; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, Tg2576, 16.5-17.7 months); 50% DMSO used; 50% PEG 300 used; dose-response (pg6932); neurodegenerative (Alzheimer's disease); behavioral testing (locomotor activity); long-term study;.

15257 Sumida, T., Naito, A.T., Nomura, S., Nakagawa, A., Higo, T., Hashimoto, A., Okada, K., Sakai, T., Ito, M., Yamaguchi, T., Oka, T., Akazawa, H., Lee, J.K., Minamino, T., Offermanns, S., Noda, T., Botto, M., Kobayashi, Y., Morita, H., Manabe, I., Nagai, T., Shiojima, I., Komuro, I., Komuro, I. Complement C1q-induced activation of beta-catenin signalling causes hypertensive arterial remodelling. Nature Communications 2015; 6(--):U43-U54. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, C57BL/6, 8-10 weeks old); cardiovascular; peptides; bp measured using tail cuff; long-term study;.

15083 Shultz, S.R., Wright, D.K., Zheng, P., Stuchbery, R., Liu, S.J., Sashindranath, M., Medcalf, R.L., Johnston, L.A., Hovens, C.M., Jones, N.C., O'Brien, T.J., Shultz, S.R. Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury. BRAIN 2015; 138(--):1297-1313. >>> Sodium selenate; Saline; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (Long Evans hooded, 12 weeks old, 250-300g); pumps replaced every 6 weeks; long-term study; traumatic brain injury;.

15062 Plante, E., Menaouar, A., Danalache, B.A., Yip, D., Broderick, T.L., Chiasson, J.L., Jankowski, M., Gutkowska, J., Gutkowska, J. Oxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice. ENDOCRINOLOGY 2015; 156(--):1416-1428. >>> Oxytocin; NaCl; BSA; sodium citrate; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (C57BL/KsJ-leptdb-leptdb); functionality of mp verified by plasma levels; pumps replaced every 6 weeks; long-term study; diabetes;“After 6 weeks, the osmotic pumps were replaced to adjust the OT concentration for body weight gain.” pg 1417;.

15255 Mennenga, S.E., Gerson, J.E., Koebele, S.V., Kingston, M.L., Tsang, C.W.S., Engler-Chiurazzi, E.B., Baxter, L.C., Bimonte-Nelson, H.A., Bimonte-Nelson, H.A. Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: Tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity. PSYCHONEUROENDOCRINOLOGY 2015; 54(--):1-13. >>> Estradiol, ethinyl; Propylene glycol; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Fischer-344, OVX, 3 months old); functionality of mp verified by serum levels; dose-response (pg8); behavioral testing (water radial-arm maze, morris water maze, visible platform task); replacement therapy (estradiol infusion); long-term study;.

15251 Dell'Orco, J.M., Wasserman, A.H., Chopra, R., Ingram, M.A.C., Hu, Y.S., Singh, V., Wulff, H., Opal, P., Orr, H.T., Shakkottai, V.G., Shakkottai, V.G. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. JOURNAL OF NEUROSCIENCE 2015; 35(--):11292-11307. >>> Flufenamic acid; Cyclodextrin, 2-hyrdoxypropyl-b-; fast green; CSF/CNS (cerebellum); Mice; Controls received mp w/ vehicle; animal info (ATXN1[82Q], 5 weeks old); 0.1% fast green used; neurodegenerative (Degenerative ataxia); brain tissue distribution; pumps primed;"An inert dye, fast green, was introduced into the osmotic pump to reveal the extent of cerebellar perfusion (Fig. 8G). Perfusion was very focal in the midline cerebellum, restricted to lobules III–V"(pg 11).; long-term study;.

15002 Lee, S.H., Moon, S.J., Paeng, J., Kang, H.Y., Nam, B.Y., Kim, S., Kim, C.H., Lee, M.J., Oh, H.J., Park, J.T., Han, S.H., Yoo, T.H., Kang, S.W., Kang, S.W. Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions. APOPTOSIS 2015; 20(--):1056-1071. >>> zAsp-DCB; SC; Rat; Animal info (male, Sprague Dawley, 250-280g, 9-10 weeks old); long-term study; diabetes; enzyme inhibitor (pan-caspase);.

15250 Lam, V., Takechi, R., Pallabage-Gamarallage, M., Giles, C., Mamo, J.C.L., Mamo, J.C.L. The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders. PLoS One 2015; 10(--):U4547-U4566. >>> Parathyroid hormone (1-34); Saline, isosmotic; cysteine; SC; Rat; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 7 weeks old); functionality of mp verified by residual volume and serum levels; 2% cysteine used; replacement therapy (parathyroid replacement); used wound clips; used 2ML size pumps; pumps primed; long-term study;.

14975 Ishikawa, Y., Imagama, S., Ohgomori, T., Ishiguro, N., Kadomatsu, K., Kadomatsu, K. A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury. NEUROSCIENCE LETTERS 2015; 593(--):13-18. >>> Keratanase II; chondroitinase ABC; Saline; CSF/CNS (intrathecal); Rat; 2006; Controls received mp w/ vehicle; animal info (female, Sprague Dalwey, 200-230g); spinal cord injury; behavioral testing (single pellet reaching task); used silicone tubing; long-term study;.

14968 Hopp, K., Hommerding, C.J., Wang, X.F., Ye, H., Harris, P.C., Torres, V.E., Torres, V.E. Tolvaptan plus Pasireotide Shows Enhanced Efficacy in a PKD1 Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):39-47. >>> Desmopressin; pasireotide; Mice; 1004; Controls received mp w/ saline; animal info (Pkd1 RC/RC, 3 weeks old); pumps replaced every 3 weeks; no stress (see pg. 44); long-term study; cardiovascular;“The minipumps were replaced every 3 weeks, and all animals survived the trial period.” pg 44; desmopressin aka dVAP;.

14958 Hardwick, J.C., Ryan, S.E., Powers, E.N., Southerland, E.M., Ardell, J.L., Hardwick, J.C. Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R179-R188. >>> Captopril; losartan; CGP42112A; SC; Guinea Pig; 2ML4; Animal info (male, Hartley, 9 weeks old, 500-650g); pumps replaced every 3 weeks; cardiovascular; long-term study;.

14949 Hamilton, C.B., Pest, M.A., Pitelka, V., Ratneswaran, A., Beier, F., Chesworth, B.M., Beier, F. Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis. OSTEOARTHRITIS AND CARTILAGE 2015; 23(--):1178-1185. >>> Water, distilled; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 301-325g); pumps replaced every 4 weeks; post op. care (buprenorphine 50 ug/kg SC); behavioral testing (static weight bearing, exploratory motor behavior); long-term study;.

14923 Donner, D.G., Beck, B.R., Bulmer, A.C., Lam, A.K., Du Toita, E.F., Donner, D.G. Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats. STEROIDS 2015; 94(--):60-69. >>> Trenbolone; Cyclodextrin, 2b-hydroxypropyl; water; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 32 weeks old, 300g); pumps replaced every 28 days; long-term study; cardiovascular;.

14907 de La Serre, C.B., de Lartigue, G., Raybould, H.E., Raybould, H.E. Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. PHYSIOLOGY&BEHAVIOR 2015; 139(--):188-194. >>> Endotoxin, LPS; IP; Rat; 2004; 2006; Controls received mp w/ saline; animal info (male, Wistar, 237g); functionality of mp verified by circulating LPS; long-term study;.

14875 Chang, T.T., Wu, T.C., Huang, P.H., Lin, C.P., Chen, J.S., Lin, L.Y., Lin, S.J., Chen, J.W., Chen, J.W. Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism. PLoS One 2015; 10(--):U1637-U1653. >>> Aliskiren; olmesartan; candesartan; PBS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, FVB/NJNarl, 6 weeks old); ischemia (hind limb); diabetes; long-term study;.

14828 Assaggaf, M.A., Kantarci, A., Sume, S.S., Trackman, P.C., Trackman, P.C. Prevention of Phenytoin-Induced Gingival Overgrowth by Lovastatin in Mice. AMERICAN JOURNAL OF PATHOLOGY 2015; 185(--):1588-1599. >>> Phenytoin; lovastatin; Water; propylene glycol; ethanol; SC; Mice; 2002; Controls received mp w/ vehicle or saline; animal info (male, BALB/cByJ, 8 weeks old); 9% ethanol used; 41% propylene glycol used; long-term study; phenytoin and lovastatin inside one pump; used autoclips; pumps primed in 37C saline overinight;.

14813 Aharony, I., Ehrnhoefer, D.E., Shruster, A., Qiu, X.F., Franciosi, S., Hayden, M.R., Offen, D., Offen, D. A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits. HUMAN MOLECULAR GENETICS 2015; 24(--):2604-2614. >>> ED11; Saline; water, sterile; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (5 weeks old); animal info (5 weeks old); neurodegenerative (Huntington's disease); behavioral testing (rotarod test, forced swim test, open field test, light dark choice test); long-term study; peptides; enzyme inhibitor (caspase-6);.

14802 Reizel, Y., Spiro, A., Sabag, O., Skversky, Y., Hecht, M., Keshet, I., Berman, B.P., Cedar, H., Cedar, H. Gender-specific postnatal demethylation and establishment of epigenetic memory. GENES&DEVELOPMENT 2015; 29(--):923-933. >>> Testosterone; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6, 3 or 20 weeks old); pumps replaced every 28 days; replacement therapy (testosterone replacement); long-term study; pumps primed for 48 hours in 37C saline;.

14796 Radwan, M., Wilkinson, D.J., Hui, W., Destrument, A.P.M., Charlton, S.H., Barter, M.J., Gibson, B., Coulombe, J., Gray, D.A., Rowan, A.D., Young, D.A., Young, D.A. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. ANNALS OF THE RHEUMATIC DISEASES 2015; 74(--):1580-1587. >>> MG132; DMSO; PEG 300; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BOL6J or mutant-Ub transgenic, 8 weeks old); pumps replaced every 4 weeks; 50% DMSO used; 50% PEG 300; long-term study; enzyme inhibitor (proteasome, general);.

14766 Tsutsumi, Y., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Terawaki, Y., Tanaka, T., Murase, K., Motonaga, R., Tanabe, M., Yanase, T., Nomiyama, T. Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. PLoS One 2015; 10(--):U743-U759. >>> Exendin-4; metformic; SC; Mice; 1004; Control animsl received mp w/ saline; animal info (athymic CAcN.Cg-Foxn1nu/CrlCrlj, non-diabetic, male); one group received mixture of exendin-4 and metformin; cancer (prostate); long-term study;.

14491 Xu, S.Q., Jiang, Y.W., Wang, H., Wang, Z., Liu, H.L., Peng, L., Fang, Q., Deng, T.T., You, J., Zhou, X.F., Zhang, W.J., Lou, J.N., Zhang, W.J. C-peptide ameliorates renal injury in type 2 diabetic rats through protein kinase A-mediated inhibition of fibronectin synthesis. Biochemical and Biophysical Research Communications 2015; 458(--):674-680. >>> C-peptide; IP; Rat; 2004; Controls received mp w/ saline, isotonic; animal info (male, GK, 8 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; peptides; diabetes;.

14374 Rossdeutscher, L., Li, J., Luco, A.L., Fadhil, I., Ochietti, B., Camirand, A., Huang, D.C., Reinhardt, T.A., Muller, W., Kremer, R., Kremer, R. Chemoprevention Activity of 25-Hydroxyvitamin D in the MMTV-PyMT Mouse Model of Breast Cancer. Cancer Prevention Research 2015; 8(--):120-128. >>> Dihydroxycholecalciferol, 1,25-; hydroxycholecalciferol, 25-,; Ethanol; saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, MMTV-PyMT, 4 weeks old); functionality of mp verified by blood levels; pumps replaced every 4 weeks; 20% ethanol used; cancer (breast); long-term study;.

14347 Pessoa, B.S., Becher, P.M., van Veghel, R., de Vries, R., Tempel, D., Sneep, S., Van Beusekom, H., Van Der Velden, V.H.J., Westermann, D., Danser, A.H.J., Roks, A.J.M., Roks, A.J.M. Effect of a Stable Angiotensin-(1-7) Analogue on Progenitor Cell Recruitment and Cardiovascular Function Post Myocardial Infarction. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2015; 4(--):U184-U194. >>> Angiotensin (1-7)-5, cyclic; SC; Mice; 1004; Controls received mp w/ saline; animal info (male, C57BL6); long-term study; cardiovascular; peptides;.

14308 Morin, N., Morissette, M., Gregoire, L., Di Paolo, T., Di Paolo, T. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2015; 56(--):27-38. >>> MPTP; Saline; SC; Monkey (macaque); Controls received mp w/ vehicle; animal info (female, Macaca fascicularis, ovariectomized, 4.7-7.7 years old, 2.7-4.2kg); long-term study; neurodegenerative (Parkinson's disease);.

14285 Lo, J.O., Schabel, M.C., Roberts, V.H.J., Morgan, T.K., Rasanen, J.P., Kroenke, C.D., Shoemaker, S.R., Spindel, E.R., Frias, A.E., Lo, J.O. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. American Journal of Obstetrics and Gynecology 2015; 212(--):U271-U278. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Monkey (macaque, pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Rhesus, pregnant, GD26); functionality of mp verified by blood levels; pumps replaced every 3 weeks; post op. care (cefazolin 150 mg BID); long-term study; teratology; dependence;.

14282 Liu, Y.J., Ju, T.C., Chen, H.M., Jang, Y.S., Lee, L.M., Lai, H.L., Tai, H.C., Fang, J.M., Lin, Y.L., Tu, P.H., Chern, Y.J., Chern, Y.J. Activation of AMP-activated protein kinase alpha1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human Molecular Genetics 2015; 24(--):787-801. >>> JMF1907; Saline; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (B6SJL-Tg, 6 weeks old); pumps replaced every 4 weeks; neurodegenerative (Amyotrophic lateral sclerosis); no stress (see pg. 792); behavioral testing (rotarod, forelimb grip); long-term study;.

14261 Lee, J.Y., Jahng, J.W., Kim, S.M., Kim, M.J., Lee, J.H., Lee, J.H. Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study. Journal of Oral and Maxillofacial Surgery 2015; 73(--):410-423. >>> Nerve growth factor, human B-; PBS; CSF/CNS (inferior alveolar nerve); Dog (beagle); 2ML2; Controls received mp w/ vehicle; animal info (male, beagle, 18 weeks old, 10-12 kg); good methods (picture of implant pg 413); Multiple pumps per animal (2; one pump delivered NGF other delivered PBS); used rat jugular catheter, 15 cm long; pump body placed into retromandibular area; long-term study;.

14722 Dschietzig, T.B., Krause-Relle, K., Hennequin, M., von Websky, K., Rahnenfuhrer, J., Ruppert, J., Groena, H.J., Armbruster, F.P., Bathgate, R.A.D., Aschenbach, J.R., Forssmann, W.G., Hocher, B., Dschietzig, T.B. Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes. KIDNEY&BLOOD PRESSURE RESEARCH 2015; 40(--):77-88. >>> Relaxin-2; Mice; 2006; Controls received mp w/ vehicle; animal info (male, eNOS, 8 weeks old); long-term study;.

14698 Cifuentes, D., Poittevin, M., Dere, E., Broqueres-You, D., Bonnin, P., Benessiano, J., Pocard, M., Mariani, J., Kubis, N., Merkulova-Rainon, T., Levy, B.I., Levy, B.I. Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the Disease. Hypertension 2015; 65(--):218-+. >>> Angiotensin II; SC; Mice; 2006; Animal info (male, APPPS1 heterozygous, 7 weeks old); pumps replaced every 6 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (memory test, locomotor activity; long-term study; cardiovascular; peptides; bp measured using tail cuff;.

14664 Aprahamian, T.R., Zhong, X.M., Amir, S., Binder, C.J., Chiang, L.K., Al-Riyami, L., Gharakhanian, R., Harnett, M.M., Harnett, W., Rifkin, I.R., Aprahamian, T.R. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology 2015; 45(--):203-207. >>> ES-62; PBS; Mice; Controls received mp w/ vehicle; animal info (male, Gld.apoE -/-); pumps replaced every 3 weeks; long-term study; cardiovascular; immunology; ES-62 is a phosphorylcholine-containing glycoprotein;.

14646 Tan, C.C., Zhang, J.G., Tan, M.S., Chen, H., Meng, D.W., Jiang, T., Meng, X.F., Li, Y., Sun, Z., Li, M.M., Yu, J.T., Tan, L., Yu, J.T. NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model. Journal of Neuroinflammation 2015; 12(--):U1-U12. >>> RNA, small interfering; CSF/CNS (third ventricle); Rat; 2006; Control animals received mp w/ control siRNA in aCSF; animal info (Sprague Dawley, 260-300 g); long-term study;.

14644 Sagy-Bross, C., Kasianov, K., Solomonov, Y., Braiman, A., Friedman, A., Hadad, N., Levy, R., Levy, R. The role of cytosolic phospholipase A(2)alpha in an amyloid precursor protein induction by amyloid beta(1-42): implication for neurodegeneration. Journal of Neurochemistry 2015; 132(--):559-571. >>> Amyloid protein, beta (1-42); Hepes; CSF/CNS; Mice; Control animal received mp w/ vehicle; animal info (male, C57BL/6); ALZET brain infusion kit 3 used; behavioral testing (Y maze test); long-term study.

14593 Doria, J.G., de Souza, J.M., Andrade, J.N., Rodrigues, H.A., Guimaraes, I.M., Carvalho, T.G., Guatimosim, C., Dobransky, T., Ribeiro, F.M., Ribeiro, F.M. The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease. NEUROBIOLOGY OF DISEASE 2015; 73(--):163-173. >>> CDPPB; DMSO; SC; Mice; 2006; Control animals received mp w/ vehicle; animal info (FVB/NJ, FVB/N-Tg); long-term study; CDPPB is a mGluR5 PAM, a metabotropic glutamate receptor 5 positive allosteric modulator; neurodegenerative disease (Huntington's disease).

13682 Llorens-Martin, M., Jurado-Arjona, J., Avila, J., Hernandez, F., Hernandez, F. Novel connection between newborn granule neurons and the hippocampal CA2 field. Experimental Neurology 2015; 263(--):285-292. >>> Endotoxin, LPS; PBS; SC; Mice; 1004; Animal info (female, 8 wks old, C57BL/6JRcc); long-term delivery; pumps replaced after 4 weeks.


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What researchers are saying...

“This study demonstrates the value of osmotic pumps as effective delivery vehicles for drugs in wild demersal fish.” (p.1024). “We conclude that the administration of T3 by osmotic pumps is an effective means of creating experimental hyperthyroidism in wild Atlantic cod.Similarly, the administration of methimazole, thiourea, or testosterone with osmotic pumps was effective in rendering cod hypothyroid.” (p.1025) Comeau et al., Transactions of the American Fisheries Society 2003;132:1021-1026.