References on the Administration of Agents Using Multiple ALZET® Osmotic Pumps in a Single Animal

16304 Bazargan, M., Foster, D. J., Muhlhausler, B. S., Morrison, J. L., McMillen, I., Davey, A. K. Limited fetal metabolism of rosiglitazone: Elimination via the maternal compartment in the pregnant ewe. Reprod Toxicol 2016; 61(--):162-8. >>> Rosiglitazone Maleate; Water, Ethanol; SC; Sheep (pregnant); 2ML1; animal info (Singleton pregnant sheep); functionality of mp verified by plasma level, amniotix fluid samples; 15% ethanol used; Multiple pumps per animal (4); stability verified by regular plasma level measurements (reached after day 5, tested through day 16; half life of 24-48 hours in sheep); Catheters flushed with heparinized saline; Dose (2.7 mg/fetus/d);.

16084 Zhao, L., Zhuang, J., Xu, F. Bronchopulmonary C-fibers'IL1RI contributes to the prolonged apneic response to intra-atrial injection of capsaicin by prenatal nicotinic exposure in rat pups. Toxicol Appl Pharmacol 2016; 303(--):58-64. >>> Nicotine; methyllycaconitine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced every 28 days; Multiple pumps per animal (2); long-term study; teratology; MLA is an a7nAChR antagonist; methyllycaconitine aka MLA; Dose (nicotine 6 mg/kg/day; MLA 3 mg/kg/day);.

15937 Paine, T. A., Cooke, E. K., Lowes, D. C. Effects of chronic inhibition of GABA synthesis on attention and impulse control. Pharmacol Biochem Behav 2015; 135(--):97-104. >>> Allylglycine, L-; CSF, artificial; CSF/CNS (prefrontal cortex); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey); bilateral cannula used; Multiple pumps per animal (2); behavioral testing (standard time reaction test; locomotor activity); tissue perfusion (prefrontal cortex); enzyme inhibitor (glutamic acid decarboxylase); Dose (3.5 ug/0.5ul/h);.

15906 Fuzzati-Armentero, M. T., Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G., Blandini, F., Baqi, Y., Muller, C. E., Volpini, R., Costa, G., Simola, N., Pinna, A. Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease. J Neurochem 2015; 134(-4-):740-7. >>> MSX-3; ANR; DMSO; PEG; SC; rat; 2ML4; animal info (male, Sprague Dawley, 275-300g); Multiple pumps per animal (2); stress/adverse reaction: (see pg. 742);.

15905 Flora, G., Joseph, G., Patel, S., Singh, A., Bleicher, D., Barakat, D. J., Louro, J., Fenton, S., Garg, M., Bunge, M. B., Pearse, D. D. Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury. Cell Transplant 2013; 22(-12-):2203-17. >>> Rolipram; Saline; ethanol; SC; Rat; 2001; animal info (female, Fischer, adult, 180-200g); pumps replaced every week; pumps replaced every week; spinal cord injury; Multiple pumps per animal (2); stress/adverse reaction: (see pg.2205); post op. care (gentamicin 5 mg/kg IM QD for 7 days; Buprenex 0.3 mg/kg SC QD for 2 days; lactated ringer's solution 5ml BID PRN, bladders expressed BID); Dose (0.5 mg/kg);.

15861 Zhao, L., Zhuang, J., Zang, N., Lin, Y., Lee, L. Y., Xu, F. Prenatal nicotinic exposure upregulates pulmonary C-fiber NK1R expression to prolong pulmonary C-fiber-mediated apneic response. Toxicol Appl Pharmacol 2016; 290(--):107-15. >>> Nicotine; mecamylamine; methyllycaconitine; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-300g); pumps replaced on GD7; Multiple pumps per animal (2); no stress (see pg. 110-111); teratology; Dose (Nicotine 6 mg/kg/day; mecamylamine 0.03 mg/kg/day; methyllycaconitine 3 mg/kg/day);.

15836 H.-W. WANG,y B. S. HUANG, y A. CHEN, M. AHMAD,, R. A. WHITE AND F. H. H. LEENEN  Neuroscience 2016; 314(--):90-105. >>> Aldosterone; eplerenone; FAD286; CSF, artificial; acetonitrile; SC; CSF/CNS; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250g); 4% acetonitrile used; Multiple pumps per animal; cardiovascular; bp measured using radiotelemetry; bp measured using radiotelemetry; dose (1.5 and 7.5 ug/kg/hr Aldosterone, 5ug/day Eplerenone, 25 ug/day FAD286).

15235 Shinohara, K., Hata, T. Post-acquisition hippocampal NMDA receptor blockade sustains retention of spatial reference memory in Morris water maze. BEHAVIOURAL BRAIN RESEARCH 2014; 259(-;-):261-267. >>> AP5, D-; CSF, artificial; CSF/CNS (hippocampus); Rat; 1007D; Animal info (male, albino Wistar); pumps replaced every 7 days; Plastics One bilateral cannula used; Multiple pumps per animal (2); behavioral testing (morris water maze, probe test); tissue perfusion (hippocampus); Cannula placement verified via histological analysis; pumps primed for 24 hours in 37C saline; bilateral infusion;.

15163 Yu, Y., Xue, B.J., Wei, S.G., Zhang, Z.H., Beltz, T.G., Guo, F., Johnson, A.K., Felder, R.B., Felder, R.B. Activation of Central PPAR-gamma Attenuates Angiotensin II-Induced Hypertension. HYPERTENSION 2015; 66(--):403-411. >>> Angiotensin II; pioglitazone, GW9662; DMSO; CSF, artificial; SC; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); functionality of mp verified by residual volume; 20% DMSO used; Multiple pumps per animal (2); cardiovascular; immunology; peptides; Cannula placement verified via histologic analysis of cannula track; bp measured using radiotelemetry (DSI);.

15078 Sharma, R.K., Choudhary, R.C., Reddy, M.K., Ray, A., Ravi, K., Ravi, K. Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2015; 205(--):66-76. >>> Muscimol; SNAP; CSF, artificial; CSF/CNS (hypothalamus); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 280g); Multiple pumps per animal (2); post op. care (Gentamycin and diclofenac 2 mg/kg for 3 days; 1ml of sterile dextrose saline given IP; daily cleaning with betadine solution and nebasulf powder until wound healed); cardiovascular; antihypertensive;.

14960 Ho, Y.H., Lin, Y.T., Wu, C.W.J., Chao, Y.M., Chang, A.Y.W., Chan, J.Y.H., Chan, J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

14942 Gerritsen, K.G.F., Leeuwis, J., Koeners, M.P., Bakker, S.J.L., van Oeveren, W., Aten, J., Tarnow, L., Rossing, P., Wetzels, J.F.M., Joles, J.A., Kok, R.J., Goldschmeding, R., Nguyen, T.Q., Nguyen, T.Q. Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction. JOURNAL OF DIABETES RESEARCH 2015; ;(--):U1-U11. >>> CTGF, recombinant human; FITC-inulin; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (male, C57BL6, 10-12 weeks old, STZ); Multiple pumps per animal (2); cardiovascular; diabetes;.

14883 Chen, W.H., Mao, C.Q., Zhuo, L.L., Ong, J.L., Chen, W.H. Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects. Neural Regeneration Research 2015; 10(--):1159-1165. >>> Nerve growth factor, b-; PBS; Evans blue dye; Bone (parietal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 250-300g); 1% Evans blue used; good methods (picture of dual cannula impmlantation pg 1161); Multiple pumps per animal (2); pump with agent inserted into right pocket, pump with PBS inserted into left pocket; bilateral infusion;.

15264 Wang, J.B., Wang, H.T., Li, L.P., Yan, Y.C., Wang, W., Liu, J.Y., Zhao, Y.T., Gao, W.S., Zhang, M.X., Zhang, M.X. Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome. WORLD JOURNAL OF GASTROENTEROLOGY 2015; 21(--):9927-9935. >>> Fluorescein isothiocyanate-inulin; Saline; IP; Rat; 2001; Animal info (male, Sprague Dawley, 220 +/-20g); Multiple pumps per animal (2); used 0.22 um filter; pumps primed for 4-6 hours;.

14493 Xue, B.J., Zhang, Z.M., Beltz, T.G., Guo, F., Hay, M., Johnson, A.K., Xue, B.J. Estrogen regulation of the brain renin-angiotensin system in protection against angiotensin II-induced sensitization of hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2014; 307(--):H191-H198. >>> Angiotensin II; estradiol, 17b-; angiotensin (1-7); A-779; Saline; DMSO; SC; CSF/CNS; Rat; 2001; 2002; Animal info (Sprague Dawley, 10-12 weeks old); ALZET brain infusion kit used; Multiple pumps per animal (2); replacement therapy (ovarectomized, estradiol infusion); cardiovascular; antihypertensive; peptides; bp measured using radiotelemetry (DSI);.

14471 Wang, J.B., Wang, D.L., Wang, H.T., Wang, Z.H., Wen, Y., Sun, C.M., Zhao, Y.T., Wu, J., Liu, P., Liu, P. Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure. LABORATORY INVESTIGATION 2014; 94(--):740-751. >>> Fluorescein isothiocyanate-inulin; Saline; IP; Rat; Animal info (male, Sprague Dawley, 220g); functionality of mp verified by plasma fluorescent levels; Multiple pumps per animal (2); cardiovascular; bp measured using indwelling catheter;.

14413 Sriraman, V., Denis, D., de Matos, D., Yu, H., Palmer, S., Nataraja, S., Sriraman, V. Investigation of a thiazolidinone derivative as an allosteric modulator of follicle stimulating hormone receptor: Evidence for its ability to support follicular development and ovulation. Biochemical Pharmacology 2014; 89(--):266-275. >>> Compound 5; Solutol; SC; Rat; 1003D; Animal info (female, immature CD, 18-21 days old); functionality of mp verified by blood levels; Multiple pumps per animal (2);"As Compound 5 exhibited poor oral availability on the pharmacokinetic studies we chose Alzet pumps to investigate the pharmacodynamic effect. Alzet osmotic pumps ensure constant levels of compounds in the circulation by continuous delivery"pg 273;.

14393 Secher, A., Jelsing, J., Baquero, A.F., Hecksher-Sorensen, J., Cowley, M.A., Dalboge, L.S., Hansen, G., Grove, K.L., Pyke, C., Raun, K., Schaeffer, L., Tang-Christensen, M., Verma, S., Witgen, B.M., Vrang, N., Knudsen, L.B., Knudsen, L.B. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. Journal of Clinical Investigation 2014; 124(--):4473-4488. >>> Exendin (9-39); DPBS buffer; PBS; CSF/CNS; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 190g); Multiple pumps per animal (2, one ICV one SC); post op. care (QD Carprofen injection); peptides; used anchoring screws; pumps primed overnight at 37C saline; obesity;.

14386 Sasser, J.M., Cunningham, MW Jr, Baylis, C., Sasser, J.M. Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension. American Journal of Physiology-Renal Physiology 2014; 307(--):F1355-F1362. >>> Angiotensin II; serelaxin, recombinant human; Saline; SC; Rat; 2002; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 400-500g); pumps replaced every 2 weeks; Multiple pumps per animal (2); long-term study; cardiovascular; peptides; antihypertensive;.

14367 te Riet, L., van den Heuvel, M., Peutz-Kootstra, C.J., van Esch, J.H.M., van Veghel, R., Garrelds, I.M., Musterd-Bhaggoe, U., Bouhuizen, A.M., Leijten, F.P.J., Danser, A.H.J., Batenburg, W.W., Batenburg, W.W. Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 rats. American Journal of Physiology-Renal Physiology 2014; 306(--):F1179-F1189. >>> Aliskiren; handle region peptide, rat; Saline; SC; Rat (transgenic); 2ML4; Controls received mp w/ vehicle; animal info (Ren2 Sprague Dawley heterozygous, 400-500g); Multiple pumps per animal (2); cardiovascular; peptides; diabetes;.

14319 Nelson, B.F., Daunt, F., Monaghan, P., Wanless, S., Butler, A., Heidinger, B.J., Newell, M., Dawson, A., Dawson, A. Protracted treatment with corticosterone reduces breeding success in a long-lived bird. General and Comparative Endocrinology 2015; 210(--):38-45. >>> Corticosterone; PEG 400; SC; Bird (kittiwake); 2002; Controls received mp w/ vehicle; animal info (late incubation, 380g); functionality of mp verified by serum levels; Multiple pumps per animal (2);.

14300 Meek, T.H., Matsen, M.E., Damian, V., Cubelo, A., Chua, SC Jr, Morton, G.J., Morton, G.J. Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats With Uncontrolled Diabetes. Endocrinology 2014; 155(--):4157-4167. >>> SHU9119; leptin; melanotan-II;; Saline; PBS; water, sterile; CSF/CNS; SC; Rat; mice; Controls received mp w/ vehicle; animal info (rat - male, Wistar, adult; mice - STZ-DM, AgRP-deficient or WT); functionality of mp verified by decreased insulin plasma levels; Multiple pumps per animal (2); diabetes; melanotan-II aka MTII; delayed delivery - catheters filled with saline; received drug on day 5; bilateral infusion for rat;.

14261 Lee, J.Y., Jahng, J.W., Kim, S.M., Kim, M.J., Lee, J.H., Lee, J.H. Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study. Journal of Oral and Maxillofacial Surgery 2015; 73(--):410-423. >>> Nerve growth factor, human B-; PBS; CSF/CNS (inferior alveolar nerve); Dog (beagle); 2ML2; Controls received mp w/ vehicle; animal info (male, beagle, 18 weeks old, 10-12 kg); good methods (picture of implant pg 413); Multiple pumps per animal (2; one pump delivered NGF other delivered PBS); used rat jugular catheter, 15 cm long; pump body placed into retromandibular area; long-term study;.

14715 Dugan, L.L., Tian, L.L., Quick, K.L., Hardt, J.I., Karimi, M., Brown, C., Loftin, S., Flores, H., Moerlein, S.M., Polich, J., Tabbal, S.D., Mink, J.W., Perlmutter, J.S., Perlmutter, J.S. Carboxyfullerene Neuroprotection Postinjury in Parkinsonian Nonhuman Primates. Annals of Neurology 2014; 76(--):393-402. >>> C3; SC; IP; Monkey (macaque); 2ML4; Controls received mp w/ placebo; animal info (Macaca facicularis); Multiple pumps per animal (2); neurodegenerative (Parkinson's disease); behavioral testing (locomotor activity); stability verified by (testing at 37C, C3 is stable for>40 days); Carboxyfullerine aka C3;.

14709 Desai, B.N., Harris, R.B.S., Harris, R.B.S. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2015; 308(--):E351-E361. >>> Leptin; CSF/CNS (third ventricle; fourth ventricle); Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague Dawley, 275-300g); Multiple pumps per animal (2); tissue perfusion (third ventricle; fourth ventricle); bilateral infusion; one cannula to third ventricle second cannula to fourth ventricle; used plastics one cannula;.

15694 Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G.F., Franco, R., Lanciego, J.L., Baqi, Y., Mueller, C.E., Pinna, A., Blandini, F., Armentero, M.T., Armentero, M.T. Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease. Journal of Neuropathology and Experimental Neurology 2014; 73(--):414-424. >>> Rimonabant; MSX-3;; DMSO; PEG; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-225g); 50% DMSO used; 50% PEG used; Multiple pumps per animal (2); neurodegenerative (parkinson's disease);.

14627 Sakai, T., Kusakabe, T., Ebihara, K., Aotani, D., Yamamoto-Kataoka, S., Zhao, M.M., Gumbilai, V.M.J., Ebihara, C., izawa-Abe, M., Yamamoto, Y., Noguchi, M., Fujikura, J., Hosoda, K., Inagaki, N., Nakao, K., Kusakabe, T. Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 307(--):E712-E719. >>> Leptin, recomb.; exenatide; SC; Mice; 2002; Control animals received mp w/ saline; animal info (STZ induced diabetes, HFD 8 wks old); multiple pumps (2) implanted.

14616 Johnson, A.C., Tremble, S.M., Chan, S.L., Moseley, J., LaMarca, B., Nagle, K.J., Cipolla, M.J., Cipolla, M.J. Magnesium Sulfate Treatment Reverses Seizure Susceptibility and Decreases Neuroinflammation in a Rat Model of Severe Preeclampsia. PLoS One 2014; 9(--):U1482-U1492. >>> Magnesium sulfate; SC; Rat (pregnant); Animal info (Sprague Dawley, 14-16 wks old); multiple pumps (3) used; 2ML sized pumps used.

14575 Wedel, J., Weij, M., Smit-van Oosten, A., Hillebrands, J.L., Hillebrands, J.L. Simultaneous subcutaneous implantation of two osmotic minipumps connected to a jugular vein catheter in the rat. Laboratory Animals 2014; 48(--):338-341. >>> Dopamine, N-octanoyl; Tween 80; saline; IV (jugular); Rat; 2ML4; animal info (male, Brown Norway, 230-270 g, female, Wistar, 280-310 g); good methods;"Our data show that double pump implantation is a feasible alternative to changing pumps or the use of extracorporeal pump systems connected via a long wire to partly restrained animals."pg 338; N-octanoyl-dopamine also known as NOD; multiple pumps (2) used; two pumps connected to Y connector, in-house made Y-tube;"we showed that the simultaneous implantation of two slow-flow rate osmotic pumps connected to a jugular vein catheter is feasible and is not linked to additional signs of discomfort compared with single pump-implanted rats."pg 341.

13996 Wosiski-Kuhn, M., Erion, J.R., Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., Stranahan, A.M., Stranahan, A.M. Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice. Psychoneuroendocrinology 2014; 42(--):165-177. >>> Corticosterone; Cyclodextrin, 2-hydroxypropyl-B;; CSF/CNS (hippocampus); Mice; Controls received mp w/ vehicle and aCSF; animal info (male, C57BL6J or db/db, 5 weeks old); functionality of mp verified by hippocampal corticosterone levels; Multiple pumps per animal (2); behavioral testing (y-maze apparatus); tissue perfusion (bilateral hippocampi); immunology; Cannula placement verified via histology; used Plastics One bilateral cannula; bilateral infusion;.

13970 Thorson, J.F., Prezotto, L.D., Cardoso, R.C., Allen, C.C., Alves, B.R.C., Amstalden, M., Williams, G.L. Pharmacologic application of native GnRH in the winter anovulatory mare, II: Accelerating the timing of pregnancy. Theriogenology 2014; 81(-4-):625-631. >>> Gonadotropin-releasing hormone; Saline; SC; Horse (mare); 2ML2; 2ML4; Controls received mp w/ vehicle; animal info (female, Quarter Horse grade); pumps replaced every 14 days (2ML2) or 28 days (2ML4); Multiple pumps per animal (4 2ML2 or 2 2ML4); used contralateral side for next pump implantation; pumps removed at end of study;.

13956 Wyss, A.F., Hamadjida, A., Savidan, J., Liu, Y., Bashir, S., Mir, A., Schwab, M.E., Rouiller, E.M., Belhaj-Saif, A. Long-term motor cortical map changes following unilateral lesion of the hand representation in the motor cortex in macaque monkeys showing functional recovery of hand functions. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 2013; 31(-6-):733-760. >>> Antibody, anti-Nogo-A 11C7; CNS/CSF; CNS/CSF (intrathecal); Monkey (macaque); 2ML2; Controls received no pump treatment; animal info (macaca fascicularis, 1 female, 7 male, 4-6 years old, 3.5-6.5 kg); Multiple pumps per animal (2); behavioral testing (modified Brinkman board task, rotative Brainkman board task, Brinkman box task); One pump delivered IT, other delivered CSF/CNS using catheter; no cannula used, see pg.741; pumps removed after 4 weeks; used antibody concentration of 3 mg/ml;.

13939 Zhang, Z., Ding, L.P., Jin, Z.T., Gao, G.J., Li, H.J., Zhang, L.J., Zhang, L.N., Lu, X., Hu, L.H., Lu, B.W., Yu, X.J., Hu, T.H., Hu, T.H. Nebivolol Protects against Myocardial Infarction Injury via Stimulation of Beta 3-Adrenergic Receptors and Nitric Oxide Signaling. PLoS One 2014; 9(--):U979-U988. >>> Nebivolol; SR59230A; Mice; Controls received mp w/ vehicle; animal info (male, C57Bl6, adult, 22-25g); Multiple pumps per animal (2); cardiovascular; BP measured using tail cuff; myocardial infarction;.

13934 Zhu, F., Liu, Y., Zhao, J., Zheng, Y., Zhao, J. MINOCYCLINE ALLEVIATES BEHAVIORAL DEFICITS AND INHIBITS MICROGLIAL ACTIVATION INDUCED BY INTRAHIPPOCAMPAL ADMINISTRATION OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN ADULT RATS. Neuroscience 2014; 266(--):275-281. >>> Colony stimulating factor, GM, recombinant rat; Saline; CSF/CNS (hippocampus); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280-320g); ALZET brain infusion kit 3 used; Multiple pumps per animal (2); behavioral testing (locomotor activity; social interaction test; PPI); used dental acrylic resin; schizophrenia;.

13910 Rahn, E.J., Deng, L., Thakur, G.A., Vemuri, K., Zvonok, A.M., Lai, Y.Y., Makriyannis, A., Hohmann, A.G., Hohmann, A.G. Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Molecular Pain 2014; 10(--):U1-U19. >>> AM1710; Taxol-WIN55,212-2; AM251; AM630; DMSO; PEG 400; SC; Rat; 2ML4; Controls received mp w/ saline; animal info (male, Sprague Dawley, 300-400g); functionality of mp verified by residual volume; 50% PEG 400 used; 50% DMSO used; Multiple pumps per animal (2); stress/adverse reaction: (see pg.15); behavioral testing (mechanical threshold, cold withdrawal, locomotor activity); AM1710 is a cannabilactone CB2-selective agonist; pumps removed on day 22; WIN55,212-2 is a CB1/CB2 agonist;.

13869 Rock, M.L., Karas, A.Z., Rodriguez, K.B.G., Gallo, M.S., Pritchett-Corning, K., Karas, R.H., Aronovitz, M., Gaskill, B.N. The Time-to-Integrate-to-Nest Test as an Indicator of Wellbeing in Laboratory Mice. Journal of the American Association for Laboratory Animal Science 2014; 53(-1-):24-28. >>> Aldosterone; uridine, bromodeoxy-; Ethanol; saline; SC; Mice; Controls received mp w/ vehicle; animal info (10 mouse strains; BALB/cAnNCrl, 129S2/ SvPasCrl, FVB/NCrl, C57BL/6NCrl, C3H/HeNCrl, CB17/ Icr-Prkdcscid/IcrIcoCrl, NOD.CB17-Prkdcscid/NCrCrl, CB17.Cg/ Prkdcscid Lystbg/Crl, C57BL/6NTac, and C57BL/6NJ, carotid artery injury); 11% ethanol used; Multiple pumps per animal (2); post op. care (buprenorphine 0.05 mg/kg SC); behavioral testing (nesting behavoir); cardiovascular;.

13860 Martel, C.A., Mamedova, L.K., Minton, J.E., Jones, M.L., Carroll, J.A., Bradford, B.J., Bradford, B.J. Continuous low-dose infusion of tumor necrosis factor alpha in adipose tissue elevates adipose tissue interleukin 10 abundance and fails to alter metabolism in lactating dairy cows. Journal of Dairy Science 2014; 97(--):4897-4906. >>> Tumor necrosis factor alpha; Saline; SC; Cattle (lactating); 2ML1; Controls received mp w/ vehicle; animal info (female, Holstein, late lactation); Multiple pumps per animal (2); immunology;.

13755 Dhaher, R., Damisah, E.C., Wang, H.L., Gruenbaum, S.E., Ong, C., Zaveri, H.P., Gruenbaum, B.F., Eid, T., Eid, T. 5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. NEUROBIOLOGY OF DISEASE 2014; 67(--):18-23. >>> Aminovaleric acid, 5-; methionine sulfoximine; PBS; SC; CSF/CNS; Rat; 2ML4; 2004; Animal info (male, Sprague Dawley, 300-330g); Multiple pumps per animal (2); cyanoacrylate adhesive; Cannula placement verified via histological analysis; methionine sulfoximine aka MSO; 5-aminovaleric acid aka 5-AV; used Plastics One cannula; second mp implanted 5-7 days after first pump implantation; 2004 implanted CSF/CNS; 2ML4 SC; epilepsy;.

13752 Dange, R.B., Agarwal, D., Masson, G.S., Vila, J., Wilson, B., Nair, A., Francis, J., Francis, J. Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension. Cardiovascular Research 2014; 103(--):17-27. >>> Angiotensin II; peptide, viral inhibitory; SC; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle or control peptide; animal info (male, Sprague Dawley, 10 weeks old, 250-350g); functionality of mp verified by plasma levels ELISA; Multiple pumps per animal (2); cardiovascular; peptides; viral inhibitory peptide aka VIPER; VIPER inhibits TLR4; bp measured using radiotelemetry;.

13715 Batenburg, W.W., Verma, A., Wang, Y.Y., Zhu, P., van den Heuvel, M., van Veghel, R., Danser, A.H.J., Li, Q.H., Li, Q.H. Combined Renin Inhibition/(Pro)Renin Receptor Blockade in Diabetic Retinopathy- A Study in Transgenic (mREN2)27 Rats. PLoS One 2014; 9(--):U983-U993. >>> Aliskiren; handle region peptide; Saline; SC; Rat (transgenic); 2ML4; Animal info (heterozygous Ren2 Sprague Dawley, adult, 400-500g); Multiple pumps per animal (2); cardiovascular; peptides; diabetes; handle region peptide aka HRP;.

13653 Ohira, K., Takeuchi, R., Shoji, H., Miyakawa, T. Fluoxetine-Induced Cortical Adult Neurogenesis. Neuropsychopharmacology 2013; 38(-6-):909-920. >>> Ara-C; PBS; CSF/CNS (frontal lobe); Mice; 1004; Controls received mp w/ vehicle; animal info (male, 3 months old, C57BL/6J); ALZET brain infusion kit 3 used; ischemia (cerebral); Multiple pumps per animal (two 1004 pumps, two Brain infusion kits); tissue perfusion (frontal lobe); brain tissue distribution;.

13635 Cho, K.J., Kim, H.W., Cheon, S.Y., Lee, J.E., Kim, G.W. Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice. Biochemical and Biophysical Research Communications 2013; 441(-2-):280-285. >>> RNA, small interfering, ASK1; Nitropropanoic acid, 3-; Saline; CSF/CNS (striatum); SC; Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (male, SOD1-tg); functionality of mp verified by Western blotting; Multiple pumps per animal (2); neurodegenerative (apoptotic striatal degeneration); behavioral testing (rotarod test); tissue perfusion (striatum); 3-NP delivered SC, ASK1-siRNA delivered CSF/CNS.

13520 Altaner, C., Altanerova, V., Cihova, M., Ondicova, K., Rychly, B., Baciak, L., Mravec, B. Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario. International Journal of Cancer 2014; 134(-6-):1458-1465. >>> Fluorocytosine-5; stem cells, therapeutic; Saline; CSF/CNS; Rat; 2ML2; 2001D; Animal info (adult, male, CD, IGS); multiple pumps (2) used; cancer (Glioblastoma multiforme);"Continuous infusion of ThSCs by osmotic pumps allowed applying more than five times higher cell dose in comparison with the amount that is possible to deliver by stereotaxic injection.".

13448 Sriramula, S., Cardinale, J.P., Francis, J. Inhibition of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension. PLoS One 2013; 8(-5-):U584-U592. >>> Angiotensin II; Etanercept; Saline; cerebrospinal fluid, artificial; CSF/CNS; SC; Rat; 1004; 2004; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 10-12 weeks old); functionality of mp verified by increased BP; Multiple pumps per animal (2 pumps - one with Angiotensin, other with entanercept); post op. care (benzathine penicillin (30000 U, I.M.), buprenorphine (0.1mg/kg, S.C.) after surgery and 12 hours postop); cardiovascular; antihypertensive; peptides; bp measured using radiotelemetry (DSI);.

13407 Li, G., Liu, Y.L., Zhu, Y.B., Liu, A.J., Xu, Y.L., Li, X.F., Li, Z.Q., Su, J.W., Sun, L.Z. ACE2 Activation Confers Endothelial Protection and Attenuates Neointimal Lesions in Prevention of Severe Pulmonary Arterial Hypertension in Rats. Lung 2013; 191(-4-):327-336. >>> Resorcinolnaphthalein, A-779; DMSO; saline; SC; Rat; Controls received mp w/ vehicle or sham surgery; animal info (male, Sprague-Dawley, 200g); 50% DMSO used; Multiple pumps per animal (one group received one pump with resorcinolnaphthalein and one pump with A-779); cardiovascular; Pulmonary Arterial Hypertension (PAH); A-779 is a Mas receptor antagonist.

13380 Han, X., Zhang, D.L., Yin, D.X., Zhang, Q.D., Liu, W.H. Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA. Canadian Journal of Physiology and Pharmacology 2013; 91(-9-):708-714. >>> Dimethylarginine, asymmetric; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280+/-20g); functionality of mp verified by serum plasma levels; Multiple pumps per animal (2); cardiovascular.

13269 Liu, X.B., Terry, T., Pan, S., Yang, Z.W., Willerson, J.T., Dixon, R.A.F., Liu, Q. Targeted Delivery of Carbaprostacyclin to Ischemic Hindlimbs Enhances Adaptive Remodeling of the Microvascular Network. Hypertension 2013; 61(-5-):1036-U290. >>> Carbaprostacyclin, cPGI2;; IA (femoral); Mice; Controls received mp w/vehicle, or saline; animal info (C57 black mice (C57BL/6J), 8-12 wks old, acute ischemia model); multiple pumps per animal (2); two pumps with saline or cPGI2 for 24 hours); PE50 catheter.

13249 Spencer, T.E., Forde, N., Dorniak, P., Hansen, T.R., Romero, J.J., Lonergan, P. Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants. REPRODUCTION 2013; 146(-4-):377-387. >>> IFNT; PGE2 251; PGF2a 409; PGI2; Ethanol; saline; SC; Sheep; 2ML1; Animal info (mature Rambouillet ewes (Ovaris)); multiple pumps per animal (2); paper does not mention pumps much; recombinant ovine (ro) IFNT (101ug in vehicle), a PG mixture (PGE2 251ng, PGF2a 409ng, and PGI2 1483ng in vehicle); vehicle (2% ethanol in saline);.

13239 Burghardt, N.S., Park, E.H., Hen, R., Fenton, A.A. Adult-born hippocampal neurons promote cognitive flexibility in mice. Hippocampus 2012; 22(-9-):1795-1808. >>> Ganciclovir; Saline; SC; Mice; Controls received mp w/ ganciclovir; long-term study; animal info (male, 129Sv/Ev, 23-27wks old; GFAP-TK transgenic); multiple pumps used (2); behavioral testing (p.1796).

13234 Harris, R.B.S. Leptin-induced increase in body fat content of rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 304(-3-):E267-E281. >>> Leptin; mutein; PBS; CSF/CNS (fourth ventricle); IP; Rat; 1002; 2002; Controls received mp w/ PBS, or saline; animal info (male, sprague dawley, 320-350 g); central administration of leptin through 4th ventricle, and effect on body fat mass; 0.15 ug leptin/24 hr, or 0.6 ug leptin/24 hr; 4th ventricle; multiple pumps (2).

13121 Xue, B.J., Zhang, Z.M., Roncari, C.F., Guo, F., Johnson, A.K. Aldosterone Acting Through the Central Nervous System Sensitizes Angiotensin II-Induced Hypertension. Hypertension 2012; 60(-4-):1023-U482. >>> Angiotensin II; aldosterone; SC; CSF/CNS; Rat; 2001; 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 10-12 wks old); peptides; multiple pumps used (2).

13095 Kasberg, A.D., Brunskill, E.W., Potter, S.S. SP8 regulates signaling centers during craniofacial development. Developmental Biology 2013; 381(-2-):312-323. >>> Cyclopamine; Sodium citrate phosphate; cyclodextrin, hydroxypropyl beta; SC; Mice (pregnant); 2001D; 30% cyclodextrin used; multiple pumps used (2);"Due to the low penetrance of the rescue via IP injection... we used micro-osmotic pumps to provide a more effective method of delivering cyclopamine."pg 320; comparison of IP injections versus SC mp; teratology.

13061 Li, Y.S., Ni, S.Y., Meng, Y., Shi, X.L., Zhao, X.W., Luo, H.H., Li, X. Angiotensin II Facilitates Fibrogenic Effect of TGF-beta1 through Enhancing the Down-Regulation of BAMBI Caused by LPS: A New Pro-Fibrotic Mechanism of Angiotensin II. PLoS One 2013; 8(-10-):U317-U327. >>> Angiotensin II; endotoxin, LPS; IP; Rat; Control animals received mp w/ PBS; animal info (Wistar, male, wks old, 220-280 g); multiple pumps used (2); peptides; long-term study;.

13002 Neerhof, M.G., Khan, S., Synowiec, S., Qu, X.W., Thaete, L.G. The Significance of Endothelin in Platelet-Activating Factor-Induced Fetal Growth Restriction. REPRODUCTIVE SCIENCES 2012; 19(-11-):1175-1180. >>> Platelet-activating factor, carbamyl; ABT-546; Ethyl alcohol; propylene glycol; sodium hydroxide; IV (jugular); SC; Rat (pregnant); 2ML1; Control animals received mp w/ vehicle; animal info (Sprague Dawley, female); multiple pumps used (2).

13001 Atik, A., Sozo, F., Orgeig, S., Suri, L., Hanita, T., Harding, R., De Matteo, R. Long-Term Pulmonary Effects of Intrauterine Exposure to Endotoxin Following Preterm Birth in Sheep. REPRODUCTIVE SCIENCES 2012; 19(-12-):1352-1364. >>> Endotoxin, LPS; Saline; Intrauterine; Sheep (ewe); 2ML4; Control animals received mp w/ saline; multiple pumps used (2).

12965 Lopez-Saucedo, J., Ramon-Ugalde, J.P., Barroso-Padilla, J.D., Gutierrez-Gutierrez, A.M., Fierro, R., Pina-Aguilar, R.E. Superovulation, in vivo embryo recovery and cryopreservation for Aoudad (Ammotragus lervia) females using osmotic pumps and vitrification: a preliminary experience and its implications for conservation. TROPICAL CONSERVATION SCIENCE 2013; 6(-1-):149-157. >>> Folicle stimulating hormone, porcine; SC; Sheep; 1003D; Animal info (aoudad, aka Barbary, female); multiple pumps used (2);"the traditional procedures for superovulation in domestic ruminants are complicated and difficult to perform in wild females because the procedure requires many physical contact and repetitive procedures, i.e., the administration of FSH two times per day. Thus, we choose to deliver FSH using osmotic pumps to minimize such manipulations... and we considered that it was the best approach for wild ruminant females and most likely represents a more"physiological"delivery method, with the continuous administration of FSH rather than blood level spikes."pg 152-153.

12913 Kennedy, P.J., Feng, J., Robison, A.J., Maze, I., Badimon, A., Mouzon, E., Chaudhury, D., mez-Werno, D.M., Haggarty, S.J., Han, M.H., Bassel-Duby, R., Olson, E.N., Nestler, E.J. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature Neuroscience 2013; 16(-4-):434-U95. >>> MS-275; Cyclodextrin, hydroxypropyl beta-; CSF/CNS (nucleus accumbens); Mice; 1002; Control animals received mp w/ vehicle; animal info (C57BL/6, 8-10 wks old); bilateral cannula used; multiple pumps used (2); enzyme inhibitor (histone deacetylase, HDAC); bilateral infusion;.

12587 Nishijima, K., Shukunami, K., Yoshinari, H., Takahashi, J., Maeda, H., Takagi, h., Kotsuji, F. Interactions among pulmonary surfactant, vernix caseosa, and intestinal enterocytes: intra-amniotic administration of fluorescently liposomes to pregnant rabbits. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2012; 303(-3-):L208-L214. >>> Liposomes, fluorescently labeled; coatasome EL-01-C, hydrated; DMSO; water, distilled; Intrauterine; Rabbit (fetus); 2ML1; Control animals received mp w/ liposome alone; animal info (Japanese, White, 4.2-5.4 kg, teen); tissue perfusion (fetus);"5-cm sterile PE 60 silicone catheter with silicone flange was attached to each pump"pg L209; Fig 2, image of pump and catheter placement; multiple pumps used (2); teratology.

12343 Dorniak, P., Bazer, F.W., Wu, G.Y., Spencer, T.E. Conceptus-Derived Prostaglandins Regulate Endometrial Function in Sheep. Biology of Reproduction 2012; 87(-1-):U80-U86. >>> Interferon, tau, recomb. ovine; meloxicam; PGE2, ovine serum; PGF2a, ovine serum; PGI2, ovine serum; Ethanol; saline; Intrauterine (uterine horn); Sheep (ewe); 2ML1; Controls received mp w/ vehicle; animal info (Mature Rambouillet); tissue perfusion (intrauterine); multiple pumps used (2); enzyme inhibitor (prostaglandin synthase two).

12169 Cao, X., Peterson, J.R., Wang, G., Anrather, J., Young, C.N., Guruju, M.R., Burmeister, M.A., Iadecola, C., Davisson, R.L. Angiotensin II-Dependent Hypertension Requires Cyclooxygenase 1-Derived Prostaglandin E(2) and EP(1) Receptor Signaling in the Subfornical Organ of the Brain. Hypertension 2012; 59(-4-):869-U250. >>> Angiotensin II; SC-51089; SC; CSF/CNS; Mice; Animal info (EP1R null, COX-1 null, COX-2 null, C57BL/6, 8-10 wks old); peptides; multiple pumps (2) used; SC-51089 is an EP1R antagonist.

12166 Cardinale, J.P., Sriramula, S., Mariappan, N., Agarwal, D., Francis, J. Angiotensin II-Induced Hypertension Is Modulated by Nuclear Factor-kappa B in the Paraventricular Nucleus. Hypertension 2012; 59(-1-):113-U282. >>> Angiotensin II; nuclear factor-kappa B; Saline; CSF/CNS (paraventricular nucleus); SC; Rat; 2002; 1004; Controls received mp w/ vehicle or scrambled decoy oligodeoxynucleotide; animal info (Sprague Dawley, male, 12 wks old, 250-350 g); peptides; multiple pumps (2) used; bilateral cannula used; bilateral infusion;.

12154 Ishitobi, Y., Akiyoshi, J., Honda, S., Ninomiya, T., Kanehisa, M., Tanaka, Y., Tsuru, J., Isogawa, K., Kitamura, H., Fujikura, Y. Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats. NEUROSCIENCE RESEARCH 2012; 72(-3-):257-262. >>> Oligonucleotide, antisense; CSF/CNS; SC; Rat; 1007D; 2001; Controls received mp w/ scrambled sequence oligonucleotides; animal info (Wistar, male, 5 wks old); multiple pumps (2) used; antisense (GPR39-1b); behavioral testing (elevated plus maze, black and white box, forced swim test).

12115 Wu, Y., Collier, L., Pan, J., Qin, W., Bauman, W.A., Cardozo, C.P. Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats. SPINAL CORD 2012; 50(-1-):57-62. >>> Methylprednisolone; testosterone; Propylene glycol; SC; Rat; 2001; 2002; Controls received mp w/ vehicle; animal info (Wistar, male); multiple pumps used (2); spinal cord injury.

 

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What researchers are saying...

“We developed the optic nerve/osmotic pump infusion technique to deliver soluble ligands, agonists, or antagonists directly into the optic nerve.The advantages of this technique are that the infused drugs remain largely confined within the experimental nerve, reducing the impact of potential systemic side effects; mere placement of the catheter and subsequent infusion of the vehicle solution do not promote lesion-like changes within the optic nerve…” Rodgers et al., GLIA 41:180-190; 2003.