References on the use of ALZET® Osmotic Pumps to Study Neurodegenerative Diseases

1. Alzheimer's Disease

16232 Prokop, S., Miller, K. R., Drost, N., Handrick, S., Mathur, V., Luo, J., Wegner, A., Wyss-Coray, T., Heppner, F. L. Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J Exp Med 2015; 212(-11-):1811-8. >>> Ganciclovir; CSF, artificial; CSF/CNS (lateral ventricles); mice; 2001; Controls received mp w/ vehicle; animal info (APPPS1 transgenic mice); brain infusion cannula used; neurodegenerative (Alzheimer’s); Dose (2.5 mg/ml); Therapeutic indication (Alzheimer’s Disease);.

16226 Parsi, S., Smith, P. Y., Goupil, C., Dorval, V., Hebert, S. S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids 2015; 4(--):e256. >>> miR-16 mimic; Saline; CSF/CNS (ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info (Wild-type mice (C57BL/6, female, 2 months old)); ALZET brain infusion kit 2 used; dose-response (pg. 2); neurodegenerative (Alzheimer’s); post op. care (Anafen); replacement therapy (miRNA replacement therapy); brain tissue distribution; delayed delivery (12 hours delivery/day); potent inhibitor of amyloid precursor protein (APP) and BACE1 expression, AǞpeptide production, and Tau phosphorylation in cells; Dose (4.2Ǩg/Ǩl); Brain coordinates; ventricle A/P =−0.22 M/L = 0.5 D/v = 3.5).

16192 Kim, J., Yoon, H., Horie, T., Burchett, J. M., Restivo, J. L., Rotllan, N., Ramirez, C. M., Verghese, P. B., Ihara, M., Hoe, H. S., Esau, C., Fernandez-Hernando, C., Holtzman, D. M., Cirrito, J. R., Ono, K., Kim, J. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J Neurosci 2015; 35(-44-):14717-26. >>> anti-miR-33; CSF/CNS (intracerevrovenctricular); Mice; Controls received negative control; animal info: mir-33 knock-out mice, two month-old APPsw/PSEN1_9 (APP/PS1) transgenic mice; neurodegenerative (Alzheimer’s); immunology; brain tissue distribution; Dose: 30 ug/d.

16173 Schoch, K. M., DeVos, S. L., Miller, R. L., Chun, S. J., Norrbom, M., Wozniak, D. F., Dawson, H. N., Bennett, C. F., Rigo, F., Miller, T. M. Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. Neuron 2016; 90(-5-):941-7. >>> Oligonucleotides, antisense; CSF/CNS; Mice (transgenic); Controls received mp w/ saline or scrambled ASO; animal info (hTau transgenic or tau N279k transgenic, 3-4 months old); antisense ( 3R to 4R MAPT splicing ASO; 4R to 3R MAPT splicing ASO); neurodegenerative (Alzheimer’s disease); behavioral testing (nesting behavior); cyanoacrylate adhesive; pumps primed in 37C saline overnight; Industry authored (Ionis Pharmaceuticals); Dose (14 ug/day for 3R to 4R MAPT splicing ASO; 25 ug/day for 4R to 3R MAPT splicing ASO); Brain coordinates (-1.1mm M/L, -0.5mm A/P, -2.5mmD/V from bregma supplement pg 5);.

16090 Ziehm, T., Brener, O., van Groen, T., Kadish, I., Frenzel, D., Tusche, M., Kutzsche, J., Reiss, K., Gremer, L., Nagel-Steger, L., Willbold, D. Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Abeta Species. ACS Chem Neurosci 2016; 7(-8-):1088-96. >>> cD3r; Saline; IP; Mice (transgenic); 1004; Controls received mp w/ vehicle; animal info (male, Tg-SwDI, 48 weeks old); neurodegenerative (Alzheimer’s disease); behavioral testing (zero maze, open field test); “treatment with compound or saline had no side effects regarding exploratory behavior and anxiolytic activity of Tg- SwDI mice. ” pg 1092; Dose (4.2 mg/kg/day);.

16053 Uekawa, K., Hasegawa, Y., Senju, S., Nakagata, N., Ma, M., Nakagawa, T., Koibuchi, N., Kim-Mitsuyama, S. Intracerebroventricular Infusion of Angiotensin-(1-7) Ameliorates Cognitive Impairment and Memory Dysfunction in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis 2016; 53(-1-):127-33. >>> Angiotensin (1-7); A-779; CSF, artificial; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (male, 5XFAD, 17 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer’s Disease); behavioral testing (Morris water maze); cardiovascular; peptides; used ALZET CSF formulation; Dose (Ang 1-7 500 ng/kg/h; A-779 5.0 ug/kg/h); Brain coordinates (relation to bregma 1.0mm lateral and 0.5 mm posterior);.

16052 Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L., Ottinger, M. A. A comparative evaluation of treatments with 17beta-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease. Horm Behav 2016; 83(--):39-44. >>> DHED; estradiol, 17B-; Propylene glycol; SC; Mice (transgenic); 2004; Controls received mp w/ vehicle; animal info (female, APPswe/PS1dE9, 6 months old); functionality of mp verified by plasma levels (see figure S1 - E2 only; no assay for DHED); pumps replaced every 4 weeks; neurodegenerative (Alzheimer’s); replacement therapy (estradiol infusion); DHED aka 10Ǟ,17Ǟ-dihydroxyestra-1,4-dien-3-one; Dose (2 ug/day); Industry authored (AgyPharma LLC);.

15988 Hwang, C. J., Yun, H. M., Park, K. R., Song, J. K., Seo, H. O., Hyun, B. K., Choi, D. Y., Yoo, H. S., Oh, K. W., Hwang, D. Y., Han, S. B., Hong, J. T. Memory Impairment in Estrogen Receptor alpha Knockout Mice Through Accumulation of Amyloid-beta Peptides. Mol Neurobiol 2015; 52(-1-):176-86. >>> Amyloid protein, beta (1-42); Saline, sterile; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (female, ER-a, 24-28g); ALZET brain infusion kit 1 used; neurodegenerative (alzheimer's disease); behavioral testing (Morris Water Maze, Probe test, passive avoidance);.

15746 Jia Chen, Cheng-Ren Li, Heng Yang, Juan Liu, Tao Zhang, Shu-Sheng Jiao, Yan-Jiang Wang, Zhi-Qiang Xu. proBDNF Attenuates Hippocampal Neurogenesis and Induces Learning and Memory Deficits in Aged Mice. NEUROTOXICITY RESEARCH 2016; (-29-):47-53. >>> Brain-derived neurotrophic factor, pro; antibody brain-derived neurotrophic factor, anti-pro;; BSA; CSF/CNS (hippocampus); Mice; 1002; Controls received mp w/ vehicle; Controls received mp w/ vehicle; neurodegenerative (Alzheimer's Disease); behavioral testing (morris water maze); Cannula placement verified postmortem;.

15735 Oleksandr Brener,, Tina Dunkelmann,, Lothar Gremer,, Thomas van Groen,, Ewa A. Mirecka,, Inga Kadish,, Antje Willuweit,, Janine Kutzsche,, Dagmar Jürgens,, Stephan Rudolph,, Markus Tusche,, Patrick Bongen,, Jörg Pietruszka,, Filipp Oesterhelt,, Karl-Josef Langen,, Hans-Ulrich Demuth,, Arnold Janssen,, Wolfgang Hoyer,, Susanne A. Funke,, Luitgard Nagel-Steger, &Dieter Willbold. QIAD assay for quantitating a compound’s efficacy in elimination of toxic AǞoligomers. SCIENTIFIC REPORTS 2015; 5(-13222-):. >>> D-peptide D3; D3D3; PBS; IP; Mice (transgenic); 1004; 2004; Controls received mp w/ vehicle; animal info (female, tg/tg TBS2.1 or Tg-SwDI23, 4 months old); neurodegenerative (Alzheimer's disease); behavioral testing (object recognition test; open field, zero maze test; Morris Water Maze); peptides; Dose (1.4, 5.1 mg/kg/day);.

15180 Nygaard, H.B., Kaufman, A.C., Sekine-Konno, T., Huh, L.L., Going, H., Feldman, S.J., Kostylev, M.A., Strittmatter, S.M., Nygaard, H.B. Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. ALZHEIMERS RESEARCH&THERAPY 2015; 7(--):U1-U12. >>> Brivaracetam; Saline; IP; Mice (transgenic); Controls received mp w/ vehicle; animal info (APP/PS1 triple transgenic); neurodegenerative (Alzheimer's disease); behavioral testing (morris water maze);“For brivaracetam, an osmotic minipump is the most reliable route of administration for continuous dosing.” pg 4;.

15164 Yun, H.M., Kim, J.A., Hwang, C.J., Jin, P., Baek, M.K., Lee, J.M., Hong, J.E., Lee, S.M., Han, S.B., Oh, K.W., Choi, D.Y., Yoon, D.Y., Hong, J.T., Hong, J.T. Neuroinflammatory and Amyloidogenic Activities of IL-32beta in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2015; 52(--):341-352. >>> Amyloid protein, beta (1-42); Saline; CSF/CNS; Mice (transgenic); 2002; Controls received mp w/ control amyloid protein, beta (42-1); animal info (female, C57BL6 or IL-32B Tg, 26-30g, 16-22 weeks); ALZET brain infusion kit 1 used; neurodegenerative (Alzheimer's); immunology;.

15151 Yang, H.J., Kwon, D.Y., Kim, M.J., Kang, S., Moon, N.R., Daily, J.W., Park, S., Park, S. Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutrition&Metabolism 2015; 12(--):U15-U26. >>> Amyloid protein, beta (25-35); CSF/CNS (hippocampus); Rat; Controls received mp w/ scrambled amyloid protein; animal info (male, Sprague Dawley, 192 +/-30g, ); neurodegenerative (Alzheimer's disease); behavioral testing (locomotive activity, passive avoidance, Morris water maze); tissue perfusion (CA1 subregion of hippocampus); diabetes;.

15104 Thakker, D.R., Sankaranarayanan, S., Weatherspoon, M.R., Harrison, J., Pierdomenico, M., Heisel, J.M., Thompson, L.A., Haskell, R., Grace, J.E., Taylor, S.J., Albright, C.F., Shafer, L.L., Shafer, L.L. Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. JOURNAL OF NEUROSCIENCE 2015; 35(--):6931-6936. >>> Compound c; PBS; DMSO; PEG 300; SC; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, Tg2576, 16.5-17.7 months); 50% DMSO used; 50% PEG 300 used; dose-response (pg6932); neurodegenerative (Alzheimer's disease); behavioral testing (locomotor activity); long-term study;.

15096 Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X.G., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S., Okazawa, H., Okazawa, H. Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. HUMAN MOLECULAR GENETICS 2015; 24(--):540-558. >>> Go6976; MLR1023; KN-93; DMSO; PBS; Mice (transgenic); 1003D; Animal info (male, APP770 human double mutant); 0.1% DMSO used; neurodegenerative (Alzheimer's); behavioral testing (morris water maze, rotarod test, fear-conditioning, light-dark box, elevated plus maze);.

15041 Mohamed, L.A., Qosa, H., Kaddoumi, A., Kaddoumi, A. Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastignnine in Rats. ACS Chemical Neuroscience 2015; 6(--):725-736. >>> Donepezil; rivastigmine; Water, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (Sprague dawley,m 4 months or 24 months); neurodegenerative (Alzheimer's disease); pumps removed after 26 days;.

14981 Jiang, N., Leithold, L.H.E., Post, J., Ziehm, T., Mauler, J., Gremer, L., Cremer, M., Schartmann, E., Shah, N.J., Kutzsche, J., Langen, K.J., Breitkreutz, J., Willbold, D., Willuweit, A., Willbold, D. Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer's Disease. PLoS One 2015; 10(--):U1253-U1267. >>> D-peptide D3, tritium labelled; IP; Mice; 1007D; Animal info (male, C57Bl6, 19 months old, 34g); neurodegenerative (Alzheimer's disease); peptides;.

14948 Hall, A.M., Throesch, B.T., Buckingham, S.C., Markwardt, S.J., Peng, Y., Wang, Q., Hoffman, D.A., Roberson, E.D., Hoffman, D.A. Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease. JOURNAL OF NEUROSCIENCE 2015; 35(--):6221-6230. >>> Levetiracetam; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (hAPPJ20 on C57BL6J background); neurodegenerative (Alzheimer's disease); pumps primed at 37C for 24 hours;.

14918 Dewji, N.N., Singer, S.J., Masliah, E., Rockenstein, E., Kim, M., Harber, M., Horwood, T., Dewji, N.N. Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce beta-Amyloid in Alzheimer's Disease. PLoS One 2015; 10(--):U263-U284. >>> P4; P8; PBS; CSF/CNS; Mice (transgenic); 1002; Controls received mp w/ vehicle; animal info (mThy1-hAPP Tg, 6 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); brain tissue distribution; peptides;.

14911 gado-Cortes, M.J., Espinosa-Oliva, A.M., Sarmiento, M., Argueelles, S., Herrera, A.J., Maurino, R., Villaran, R.F., Venero, J.L., Machado, A., de Pablos, R.M., de Pablos, R.M. Synergistic Deleterious Effect of Chronic Stress and Sodium Azide in the Mouse Hippocampus. CHEMICAL RESEARCH IN TOXICOLOGY 2015; 28(--):651-661. >>> Sodium azide; SC; Mice; 2004; Controls received mp w/ isotonic saline; animal info (male, C57Bl6, 25-30g); pumps replaced every month; neurodegenerative (Alzheimer's disease);.

14884 Cherry, J.D., Olschowka, J.A., O'Banion, M.K., O'Banion, M.K. Arginase 1+ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U14-U26. >>> Antibody, interleukin-4Ra; CSF/CNS (hippocampus); Mice; 1004; Controls received mp w/ control antibody; animal info (APPswe/SP1dE9, 7-5 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); immunology; pumps primed 48 hours in 37C saline;.

14863 Castaneda, M.T., Lopez, E.D., Touhami, A., Tovar, R., Ortega, M.R., Rodriguez, J.M., Castaneda, M.T. Neuroprotection of medial septal cholinergic neurons by memantine after intralateral septal injection of Abeta(1-40). NEUROREPORT 2015; 26(--):450-454. >>> Memantine; SC; Rat; 2ML2; Animal info (male, Sprague Dawley, 300-400g); neurodegenerative (Alzheimer's disease); brain tissue distribution;.

14858 Caetano, A.L., Dong-Creste, K.E., Amaral, F.A., Monteiro-Silva, K.C., Pesquero, J.B., Araujo, M.S., Montor, W.R., Vie, T.A., Buck, H.S., Buck, H.S. Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease. NEUROPEPTIDES 2015; 53(--):51-62. >>> E-64; amyloid protein, beta (1-40); HEPES; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6 or KOB1 or KOB2, 28-31g, ); neurodegenerative (Alzheimer's disease); enzyme inhibitor (cystein protease);.

14816 Alkadhi, K.A., Tran, T.T., Alkadhi, K.A. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2015; 52(--):93-100. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoracetic acid; CSF/CNS; Rat; Controls received mp w/ control peptide amyloid protein, beta (42-1); animal info (Wistar, 200-225g); 0.1% trifluoroacetic acid used; neurodegenerative (Alzheimer's disease);.

14518 Yuyama, K., Sun, H., Usuki, S., Sakai, S., Hanamatsu, H., Mioka, T., Kimura, N., Okada, M., Tahara, H., Furukawa, J., Fujitani, N., Shinohara, Y., Igarashi, Y., Yuyama, K. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide. FEBS Letters 2015; 589(--):84-88. >>> Exosome; PBS; CSF/CNS (hippocampus); Mice; Animal info (APP or C57BL6J, 13 months old); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); tissue perfusion (hippocampus);.

14500 Yang, H.J., Kwon, D.Y., Kim, H.J., Kim, M.J., Jung, D.Y., Kang, H.J., Kim, D.S., Kang, S., Moon, N.R., Shin, B.K., Park, S., Park, S. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia. EUROPEAN JOURNAL OF NUTRITION 2015; 54(--):77-88. >>> Amyloid protein, beta (35-25); amyloid protein, beta (25-35); Saline; CSF/CNS (hippocampus); Rat; Controls received mp w/ control B-amyloid protein (25-35); animal info (male, Sprague Dawley, 223g); bilateral cannula used; neurodegenerative (alzheimer's); behavioral testing (locomotor activity, passive avoidance test, morris water maze); diabetes;.

14487 Xi, Y.D., Ding, J., Han, J., Zhang, D.D., Liu, J.M., Feng, L.L., Xiao, R., Xiao, R. The Effect of Soybean Isoflavone on the Dysregulation of NMDA Receptor Signaling Pathway Induced by beta-Amyloid Peptides 1-42 in Rats. Cellular and Molecular Neurobiology 2015; 35(--):555-562. >>> Amyloid protein, beta (1-42); CSF/CNS; Rat; 2002; Controls received mp w/ saline; animal info (male, Wister, 250-300g); neurodegenerative (Alzheimer's disease);.

14372 Rojanathammanee, L., Floden, A.M., Manocha, G.D., Combs, C.K., Combs, C.K. Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. Journal of Neuroinflammation 2015; 12(--):U14-U26. >>> FK506; tat-VIVIT; tat-VEET; DMSO; HEPES; SC; Mice (transgenic); 1004; Controls received mp w/ vehicle; animal info (male, APP/PS1, 12 months old); neurodegenerative (Alzheimer's); behavioral testing (t maze); peptides; FK506, tat-VIVIT are NFAT inhibitors; VEET is a negative control scrambled peptide;.

14222 Hopp, S.C., D'Angelo, H.M., Royer, S.E., Kaercher, R.M., Crockett, A.M., Adzovic, L., Wenk, G.L., Wenk, G.L. Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U1-U14. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ aCSF; animal info (male F-344, 3 months old); neurodegenerative (Alzheimer's disease); behavioral testing (Morris Water Maze); immunology;.

14717 Dai, C.L., Chen, X., Kazim, S.F., Liu, F., Gong, C.X., Grundke-Iqbal, I., Iqbal, K., Iqbal, K. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of Neural Transmission 2015; 122(--):607-617. >>> Antibody, HJ9.4; antibody, HJ8.5; antibody, HJ9.3; CSF/CNS; Mice (transgenic); Animal info (P301S tau transgenic, 6 months old); neurodegenerative (Alzheimer's disease); behavioral testing (fear conditioning); pumps mentioned in intro;.

14698 Cifuentes, D., Poittevin, M., Dere, E., Broqueres-You, D., Bonnin, P., Benessiano, J., Pocard, M., Mariani, J., Kubis, N., Merkulova-Rainon, T., Levy, B.I., Levy, B.I. Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the Disease. Hypertension 2015; 65(--):218-+. >>> Angiotensin II; SC; Mice; 2006; Animal info (male, APPPS1 heterozygous, 7 weeks old); pumps replaced every 6 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (memory test, locomotor activity; long-term study; cardiovascular; peptides; bp measured using tail cuff;.

14696 Chu, J., Li, J.G., Joshi, Y.B., Giannopoulos, P.F., Hoffman, N.E., Madesh, M., Pratico, D., Pratico, D. Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer's Disease. Biological Psychiatry 2015; 77(--):720-728. >>> Z-DEVD-FMK; CSF/CNS (intrathecal); Mice (transgenic); 1007D; Animal info (Tg2576, 15 months old; 3Tg, 10 months old); neurodegenerative (Alzheimer's disease); z-DEVD-fmk is a caspase-3 inhibitor;.

14648 Vargas, J.Y., Ahumada, J., Arrazola, M.S., Fuenzalida, M., Inestrosa, N.C., Fuenzalida, M. WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Abeta oligomers. Experimental Neurology 2015; 264(--):14-25. >>> WASP-1; CSF/CNS (hippocampus); Mice; 1004; Control animals received aCSF; animal info (double tg APPswe/PS1dE9, male, 7 mo old); Plastics One bilateral cannula used; WASP-1 also known as Wnt-activating small molecule potentiator-1; neurodegenerative (Alzheimer's disease).

14643 Noshita, T., Murayama, N., Nakamura, S., Noshita, T. Effect of nicotine on neuronal dysfunction induced by intracerebroventricular infusion of amyloid-beta peptide in rats. European Review for Medical and Pharmacological Sciences 2015; 19(--):334-343. >>> Amyloid protein, beta (1-42); Water, sterile bidistilled; CSF/CNS; Rat; 1003D; Animal info (male, F344/DuCrj, 18 wks old, 320-360 g); neurodegenerative (Alzheimer's disease).

14631 Lauretti, E., Di Meco, A., Chu, J., Pratico, D., Pratico, D. Modulation of AD neuropathology and memory impairments by the isoprostane F2alpha is mediated by the thromboxane receptor. NEUROBIOLOGY OF AGING 2015; 36(--):812-820. >>> 8ISO; SQ29,548; CSF, artificial; CSF/CNS; Mice; 1004; Control animals received mp w/ vehicle; animal info (3xTg, PS1 M146V, tau P301L, APPWse, 7-8 mo old); artificial CSF recipe; 100 ul pump used; SQ29,548 is a selective TP antagonist; 8ISO also known as 8-isoprostane F2 alpha; neurodegenerative (Alzheimer's disease).

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2. Alzheimer’s Disease

Q4688 Nygaard,H.B., Kaufman,A.C., Sekine-Konno,T., Huh,L.L., Going,H., Feldman,S.J., Kostylev,M.A., Strittmatter,S.M., Nygaard,H.B. Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. ALZHEIMERS RESEARCH&THERAPY 2015; 7(--):U1-U12. >>> Brivaracetam; Saline; IP; Mice (transgenic); 28 days; Controls received mp w/ vehicle; animal info (APP/PS1 triple transgenic); neurodegenerative (Alzheimer's disease); behavioral testing (morris water maze);â·For brivaracetam, an osmotic minipump is the most reliable route of administration for continuous dosing.âpg 4;.

Q4670 Yun,H.M., Kim,J.A., Hwang,C.J., Jin,P., Baek,M.K., Lee,J.M., Hong,J.E., Lee,S.M., Han,S.B., Oh,K.W., Choi,D.Y., Yoon,D.Y., Hong,J.T., Hong,J.T. Neuroinflammatory and Amyloidogenic Activities of IL-32beta in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2015; 52(--):341-352. >>> Amyloid protein, beta (1-42); Saline; CSF/CNS; Mice (transgenic); 2002; 14 days; Controls received mp w/ control amyloid protein, beta (42-1); animal info (female, C57BL6 or IL-32B Tg, 26-30g, 16-22 weeks); ALZET brain infusion kit 1 used; neurodegenerative (Alzheimer's); immunology;.

Q4656 Yang,H.J., Kwon,D.Y., Kim,M.J., Kang,S., Moon,N.R., Daily,J.W., Park,S., Park,S. Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutrition&Metabolism 2015; 12(--):U15-U26. >>> Amyloid protein, beta (25-35); CSF/CNS (hippocampus); Rat; 14 days; Controls received mp w/ scrambled amyloid protein; animal info (male, Sprague Dawley, 192 +/-30g, ); neurodegenerative (Alzheimer's disease); behavioral testing (locomotive activity, passive avoidance, Morris water maze); tissue perfusion (CA1 subregion of hippocampus); diabetes;.

Q4610 Thakker,D.R., Sankaranarayanan,S., Weatherspoon,M.R., Harrison,J., Pierdomenico,M., Heisel,J.M., Thompson,L.A., Haskell,R., Grace,J.E., Taylor,S.J., Albright,C.F., Shafer,L.L., Shafer,L.L. Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. Journal of Neuroscience 2015; 35(--):6931-6936. >>> Compound c; PBS; DMSO; PEG 300; SC; CSF/CNS; Mice; 2006; 8 weeks; Controls received mp w/ vehicle; animal info (male, Tg2576, 16.5-17.7 months); 50% DMSO used; 50% PEG 300 used; dose-response (pg6932); neurodegenerative (Alzheimer's disease); behavioral testing (locomotor activity); long-term study;.

Q4533 Mohamed,L.A., Qosa,H., Kaddoumi,A., Kaddoumi,A. Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastignnine in Rats. ACS CHEMICAL NEUROSCIENCE 2015; 6(--):725-736. >>> Donepezil; rivastigmine; Water, sterile; SC; Rat; 2ML4; 26 days; Controls received mp w/ vehicle; animal info (Sprague dawley,m 4 months or 24 months); neurodegenerative (Alzheimer's disease); pumps removed after 26 days;.

Q4467 Jiang,N., Leithold,L.H.E., Post,J., Ziehm,T., Mauler,J., Gremer,L., Cremer,M., Schartmann,E., Shah,N.J., Kutzsche,J., Langen,K.J., Breitkreutz,J., Willbold,D., Willuweit,A., Willbold,D. Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer's Disease. PLoS One 2015; 10(--):U1253-U1267. >>> D-peptide D3, tritium labelled; IP; Mice; 1007D; 6 days; Animal info (male, C57Bl6, 19 months old, 34g); neurodegenerative (Alzheimer's disease); peptides;.

Q4439 Hall,A.M., Throesch,B.T., Buckingham,S.C., Markwardt,S.J., Peng,Y., Wang,Q., Hoffman,D.A., Roberson,E.D., Hoffman,D.A. Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience 2015; 35(--):6221-6230. >>> Levetiracetam; Saline; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (hAPPJ20 on C57BL6J background); neurodegenerative (Alzheimer's disease); pumps primed at 37C for 24 hours;.

Q4403 Dewji,N.N., Singer,S.J., Masliah,E., Rockenstein,E., Kim,M., Harber,M., Horwood,T., Dewji,N.N. Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce beta-Amyloid in Alzheimer's Disease. PLoS One 2015; 10(--):U263-U284. >>> P4; P8; PBS; CSF/CNS; Mice (transgenic); 1002; 2 weeks; Controls received mp w/ vehicle; animal info (mThy1-hAPP Tg, 6 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); brain tissue distribution; peptides;.

Q4397 gado-Cortes,M.J., Espinosa-Oliva,A.M., Sarmiento,M., Argueelles,S., Herrera,A.J., Maurino,R., Villaran,R.F., Venero,J.L., Machado,A., de Pablos,R.M., de Pablos,R.M. Synergistic Deleterious Effect of Chronic Stress and Sodium Azide in the Mouse Hippocampus. Chemical Research In Toxicology 2015; 28(--):651-661. >>> Sodium azide; SC; Mice; 2004; 1 month; 2 months; Controls received mp w/ isotonic saline; animal info (male, C57Bl6, 25-30g); pumps replaced every month; neurodegenerative (Alzheimer's disease);.

Q4370 Cherry,J.D., Olschowka,J.A., O'Banion,M.K., O'Banion,M.K. Arginase 1+ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U14-U26. >>> Antibody, interleukin-4Ra; CSF/CNS (hippocampus); Mice; 1004; 28 days; Controls received mp w/ control antibody; animal info (APPswe/SP1dE9, 7-5 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); immunology; pumps primed 48 hours in 37C saline;.

Q4352 Castaneda,M.T., Lopez,E.D., Touhami,A., Tovar,R., Ortega,M.R., Rodriguez,J.M., Castaneda,M.T. Neuroprotection of medial septal cholinergic neurons by memantine after intralateral septal injection of Abeta(1-40). NeuroReport 2015; 26(--):450-454. >>> Memantine; SC; Rat; 2ML2; 8 days; Animal info (male, Sprague Dawley, 300-400g); neurodegenerative (Alzheimer's disease); brain tissue distribution;.

Q4342 Caetano,A.L., Dong-Creste,K.E., Amaral,F.A., Monteiro-Silva,K.C., Pesquero,J.B., Araujo,M.S., Montor,W.R., Vie,T.A., Buck,H.S., Buck,H.S. Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease. Neuropeptides 2015; 53(--):51-62. >>> E-64; amyloid protein, beta (1-40); HEPES; CSF/CNS; Mice; 1004; 35 days; Controls received mp w/ vehicle; animal info (C57BL6 or KOB1 or KOB2, 28-31g, ); neurodegenerative (Alzheimer's disease); enzyme inhibitor (cystein protease);.

Q4304 Alkadhi,K.A., Tran,T.T., Alkadhi,K.A. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2015; 52(--):93-100. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoracetic acid; CSF/CNS; Rat; 14 days; Controls received mp w/ control peptide amyloid protein, beta (42-1); animal info (Wistar, 200-225g); 0.1% trifluoroacetic acid used; neurodegenerative (Alzheimer's disease);.

Q4217 Yuyama,K., Sun,H., Usuki,S., Sakai,S., Hanamatsu,H., Mioka,T., Kimura,N., Okada,M., Tahara,H., Furukawa,J., Fujitani,N., Shinohara,Y., Igarashi,Y., Yuyama,K. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide. FEBS Letters 2015; 589(--):84-88. >>> Exosome; PBS; CSF/CNS (hippocampus); Mice; 14 days; Animal info (APP or C57BL6J, 13 months old); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); tissue perfusion (hippocampus);.

Q4216 Yuyama,K., Sun,H., Sakai,S., Mitsutake,S., Okada,M., Tahara,H., Furukawa,J., Fujitani,N., Shinohara,Y., Igarashi,Y., Igarashi,Y. Decreased Amyloid-beta Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice. Journal of Biological Chemistry 2014; 289(--):24488-24498. >>> Exosome solution, glycosphingolipid-enriched; PBS; CSF/CNS (hippocampus); Mice (trangenic); 1002; 14 days; Controls received mp w/ vehicle; animal info (APP, 4 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimers); tissue perfusion (hippocampus);.

Q4214 Yu,C.J., Liu,W., Chen,H.Y., Wang,L., Zhang,Z.R., Zhang,Z.R. BACE1 RNA interference improves spatial memory and attenuates Abeta burden in a streptozotocin-induced tau hyperphosphorylated rat model. Cell Biochemistry and Function 2014; 32(--):590-596. >>> Okadaic acid; RNA, small interfering; SC; Rat; 1004; 16 weeks; Controls received mp w/ saline; animal info (Sprague Dawley, 11-12.5 months); pumps replaced every 4 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (morris water maze); long-term study;.

Q4199 Yang,H.J., Kwon,D.Y., Kim,H.J., Kim,M.J., Jung,D.Y., Kang,H.J., Kim,D.S., Kang,S., Moon,N.R., Shin,B.K., Park,S., Park,S. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia. EUROPEAN JOURNAL OF NUTRITION 2015; 54(--):77-88. >>> Amyloid protein, beta (35-25); amyloid protein, beta (25-35); Saline; CSF/CNS (hippocampus); Rat; 14 days; Controls received mp w/ control B-amyloid protein (25-35); animal info (male, Sprague Dawley, 223g); bilateral cannula used; neurodegenerative (alzheimer's); behavioral testing (locomotor activity, passive avoidance test, morris water maze); diabetes;.

Q4186 Xi,Y.D., Ding,J., Han,J., Zhang,D.D., Liu,J.M., Feng,L.L., Xiao,R., Xiao,R. The Effect of Soybean Isoflavone on the Dysregulation of NMDA Receptor Signaling Pathway Induced by beta-Amyloid Peptides 1-42 in Rats. Cellular and Molecular Neurobiology 2015; 35(--):555-562. >>> Amyloid protein, beta (1-42); CSF/CNS; Rat; 2002; 28 days; Controls received mp w/ saline; animal info (male, Wister, 250-300g); neurodegenerative (Alzheimer's disease);.

Q4185 Wu,C.R., Lin,H.C., Su,M.H., Wu,C.R. Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer's disease-like rat model: relevance for amyloid deposition and central neurotransmitter function. BMC Complementary and Alternative Medicine 2014; 14(--):U1-U11. >>> Amyloid protein, beta (1-42); CSF/CNS; Rat; 1004; 2 weeks; Controls received mp w/ control peptide AB (42-1); animal info (male, Wistar, 2-3 months or 10-12 months old); ALZET brain infusion kit used; neurodegenerative (Alzheimer's); post op. care (triple antibiotic cream, Baytril and buprenorphine); behavioral testing (operant sustained attention task); used dental cement and bone screws; used sutures;.

Q3983 Llorens-Martin,M., Jurado-Arjona,J., Fuster-Matanzo,A., Hernandez,F., Rabano,A., Avila,J., Avila,J. Peripherally triggered and GSK-3beta-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen. TRANSLATIONAL PSYCHIATRY 2014; 4(--):U58-U68. >>> Gallate; DMSO; saline; IP; Mice; 1002; 2 weeks; 4 weeks; 8 weeks;; Controls received mp w/ vehicle; animal info (male, ICR, 11 months old); 50% DMSO used; neurodegenerative (Alzheimer's); immunology;.

Q3921 Hopp,S.C., D'Angelo,H.M., Royer,S.E., Kaercher,R.M., Crockett,A.M., Adzovic,L., Wenk,G.L., Wenk,G.L. Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U1-U14. >>> D23; 3xD23; E2_5; PBS; CSF/CNS; Mice; 2004; 28 days; Controls received mp w/ PBS; animal info (Tg2576, 12 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's); behavioral testing (y maze); D23 and 3xD23 are designed ankyrin repeat protein (DARPins); E2_5 is a control DARPin;.

Q3861 Dai,C.L., Chen,X., Kazim,S.F., Liu,F., Gong,C.X., Grundke-Iqbal,I., Iqbal,K., Iqbal,K. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of Neural Transmission 2015; 122(--):607-617. >>> Antibody, HJ9.4; antibody, HJ8.5; antibody, HJ9.3; CSF/CNS; Mice (transgenic); 3 months; Animal info (P301S tau transgenic, 6 months old); neurodegenerative (Alzheimer's disease); behavioral testing (fear conditioning); pumps mentioned in intro;.

Q3842 Cifuentes,D., Poittevin,M., Dere,E., Broqueres-You,D., Bonnin,P., Benessiano,J., Pocard,M., Mariani,J., Kubis,N., Merkulova-Rainon,T., Levy,B.I., Levy,B.I. Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the Disease. Hypertension 2015; 65(--):218-+. >>> Angiotensin II; SC; Mice; 2006; 2.5 months; Animal info (male, APPPS1 heterozygous, 7 weeks old); pumps replaced every 6 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (memory test, locomotor activity; long-term study; cardiovascular; peptides; bp measured using tail cuff;.

Q3840 Chu,J., Li,J.G., Joshi,Y.B., Giannopoulos,P.F., Hoffman,N.E., Madesh,M., Pratico,D., Pratico,D. Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer's Disease. Biological Psychiatry 2015; 77(--):720-728. >>> Z-DEVD-FMK; CSF/CNS (intrathecal); Mice (transgenic); 1007D; 1 week; Animal info (Tg2576, 15 months old; 3Tg, 10 months old); neurodegenerative (Alzheimer's disease); z-DEVD-fmk is a caspase-3 inhibitor;.

Q3804 An,K., Jung,J.H., Jeong,A.Y., Kim,H.G., Jung,S.Y., Lee,K., Kim,H.J., Kim,S.J., Jeong,T.Y., Son,Y., Kim,H.S., Kim,J.H., Kim,J.H. Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death&Disease 2014; 5(--):U181-U190. >>> WASP-1; CSF/CNS (hippocampus); Mice; 1004; 2 weeks; Control animals received aCSF; animal info (double tg APPswe/PS1dE9, male, 7 mo old); Plastics One bilateral cannula used; WASP-1 also known as Wnt-activating small molecule potentiator-1; neurodegenerative (Alzheimer's disease).

Q3787 Noshita,T., Murayama,N., Nakamura,S., Noshita,T. Effect of nicotine on neuronal dysfunction induced by intracerebroventricular infusion of amyloid-beta peptide in rats. European Review for Medical and Pharmacological Sciences 2015; 19(--):334-343. >>> 8ISO; SQ29,548; CSF, artificial; CSF/CNS; Mice; 1004; 3 days; Control animals received mp w/ vehicle; animal info (3xTg, PS1 M146V, tau P301L, APPWse, 7-8 mo old); artificial CSF recipe; 100 ul pump used; SQ29,548 is a selective TP antagonist; 8ISO also known as 8-isoprostane F2 alpha; neurodegenerative (Alzheimer's disease).

Q3576 Murphy,N., Grehan,B., Lynch,M.A. Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10. NEUROMOLECULAR MEDICINE 2014; 16(-1-):205-215. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ control peptide; animal info (male, Wistar rat, 3-4 months); ALZET brain infusion kit 2 used; neurodegenerative (Alzheimers disease); post op. care (Rimadil 5 mg/kg); immunology; cyanoacrylate adhesive; cannula secured with cyanoacrylate gel and covered with dental cement;.

Q3564 Mellott,T.J., Pender,S.M., Burke,R.M., Langley,E.A., Blusztajn,J.K., Mellott,T.J. IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One 2014; 9(--):U264-U275. >>> Insulin-like growth factor, human recombinant; CSF/CNS; Mice; 1002; 7 days; Controls received mp w/ vehicle; animal info (APP.PS1, 6 months old); neurodegenerative (Alzheimers); post op. care (ampicillin 35 mg/kg SC; 1 ml of sterile saline SC; heating pad; buprenex 0.04 mg/kg SC); cyanoacrylate adhesive; used Loctite and dental cement;.

Q3521 Jiang,T., Yu,J.T., Zhu,X.C., Tan,M.S., Gu,L.Z., Zhang,Y.D., Tan,L., Tan,L. Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. NEUROBIOLOGY OF AGING 2014; 35(--):1243-1251. >>> RNA, small interfering TREM2; CSF, artificial; CSF/CNS (dorsal third ventricle); Mice; 1004; 4 weeks; Controls received mp w/ vehicle or control siRNA; animal info (SAMP8, 6 months old); functionality of mp verified by decrease TREM2 protein levels pg. 1246; ALZET brain infusion kit used; neurodegenerative (Alzheimers); no stress (see pg. 1244); behavioral testing (Morris water maze); tissue perfusion (third ventricle); immunology;.

Q3468 Ferreira,N., Pereira-Henriques,A., Attar,A., Klaerner,F.G., Schrader,T., Bitan,G., Gales,L., Saraiva,M.J., Almeida,M.R., Almeida,M.R. Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics 2014; 11(--):450-461. >>> CLR01; SC; Mice; 1004; 35 days; Animal info (4 months old); neurodegenerative (Alzheimer's disease; parkinson's disease); no stress (see pg.453); CLR01 inhibits self-assembly and toxicity of amyloidogenic proteins.

Q3443 Chu,J., Lauretti,E., Craige,C.P., Pratico,D., Pratico,D. Pharmacological Modulation of GSAP Reduces Amyloid-beta Levels and Tau Phosphorylation in a Mouse Model of Alzheimer's Disease with Plaques and Tangles. JOURNAL OF ALZHEIMERS DISEASE 2014; 41(--):729-737. >>> Imatinib; CSF, artificial; CSF/CNS (intrathecal); Mice (transgenic); 1007D; 1 week; Controls received mp w/ vehicle; animal info (triple transgenic ABBP, PS1, P301L); neurodegenerative (Alzheimer's); "Since it is known that the drug does not penetrate the blood-brain barrier efficiently, it is possible that the contradictory results reflect this property of the drug. For this reason in the current study, we delivered Imatinib by means of implanted osmotic minipumps directly in the brains of the triple transgenic mice" pg 730; Imatinib aka STI571 akd Gleevec; used dental cement;.

Q3417 Ben Menachem-Zidon,O., Ben Menahem,Y., Ben Hur,T., Yirmiya,R. Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer's Disease Model. Neuropsychopharmacology 2014; 39(-2-):401-414. >>> Interleukin-1, receptor antagonist; CSF/CNS; Mice (transgenic); 28 days; Controls received mp w/ vehicle; animal info (WT and Tg2576, 11 months old); pumps replaced every 2 weeks; ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); behavioral testing (fear conditioning; morris water maze); stability verified by (IL-1-ra remains effective for 2 weeks in pumps); Used three anchoring screws;.

Q3401 Akita,K., Harada,K., Ichihara,J., Takata,N., Takahashi,Y., Saito,K. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. European Journal of Pharmacology 2013; 720(-1-3-):107-114. >>> Dihydrotestosterone; methyltestosterone; NEP28; SC; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 13 weeks old); dose-response (pg.110-112); neurodegenerative (Alzheimer's disease); replacement therapy (orchidectomized; androgen therapy); dihydrotestosterone aka DHT; methyltestosterone aka MT; NEP28 is a selective androgen receptor modulator (SARM); notes the use of a 21 day pump;.

Q3400 Adler,B.L., Yarchoan,M., Hwang,H.M., Louneva,N., Blair,J.A., Palm,R., Smith,M.A., Lee,H.G., Arnold,S.E., Casadesus,G. Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition. NEUROBIOLOGY OF AGING 2014; 35(-4-):793-801. >>> Pramlintide acetate; Saline; SC; Mice; 2002; 5 weeks; Controls received mp w/ vehicle; animal info (SAMP8, 6 months old); pumps replaced every 2 weeks; neurodegenerative (Alzheimers disease); behavioral testing (object recognition test);.

Q3384 Alkadhi,K.A., Tran,T.T., Alkadhi,K.A. Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer's disease. Brain Research 2014; 1588(--):150-158. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 14 days; Animal info (Wistar, 200-225 g); peptides; 14 day pump used; neurodegenerative (Alzheimer's disease).

Q3375 Zhang,X.M., Hernandez,I., Rei,D., Mair,W., Laha,J.K., Cornwell,M.E., Cuny,G.D., Tsai,L.H., Steen,J.A.J., Kosik,K.S. Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models. Journal of Biological Chemistry 2013; 288(-30-):22042-22056. >>> LDN-193594; LCN-213828; PEG 400; DMSO; CSF/CNS; SC; Mice (transgenic); 2004; 2006; 3 weeks; 6 weeks; Controls received mp w/ vehicle; animal info (male, double transgenic CK-p25, 10 weeks old); ALZET brain infusion kit 3 used; 60% PEG 400 used 50% DMSO used; LDN-193594 half-life (p.22047); neurodegenerative (Alzheimer's); behavioral testing (fear/freezing behavior; learning and memory); cyanoacrylate adhesive; pumps primed for 2 hours in 37C saline; LDN-193594 and LCN-213828 are diaminothiazole derivatives;.

Q3372 Yun,H.M., Kim,H.S., Park,K.R., Shin,J.M., Kang,A.R., Lee,K.I., Song,S., Kim,Y.B., Han,S.B., Chung,H.M., Hong,J.T. Placenta-derived mesenchymal stem cells improve memory dysfunction in an Abeta(1-42)-infused mouse model of Alzheimer's disease. Cell Death&Disease 2013; 4(-;-):U202-U211. >>> Amyloid protein, beta (1-42); Saline; CSF/CNS; Mice; 1002; 14 days; Animal info (male, ICR mice, 20-25g); neurodegenerative (Alzheimer's disease); behavioral testing (Morris water maze, probe test, passive avoidance); immunology;.

Q3364 Vargas,J.Y., Fuenzalida,M., Inestrosa,N.C. In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model. Journal of Neuroscience 2014; 34(-6-):2191-2202. >>> WASP-1; TCS-183; FOXY-5; TAT-TI-JIP; CSF, artificial; DMSO; CSF/CNS (hippocampus); Mice (transgenic); 1004; 21 days; Controls received mp w/ vehicle; animal info (male, double transgenic APP/PS1, 7 months old); 0.01% DMSO used; neurodegenerative (alzheimer's disease); behavioral testing (memory flexibility test, water maze, novel object recognition); cyanoacrylate adhesive; WASP-1 aka Wnt activating small molecule, FOXY-5 aka formulated Wnt-5a-derived hexapeptide; Used double-brain infusion canula and bifurcation cannula from Plastics one; pumps primed at 37C for 48h..

Q3361 Spilman,P., Descamps,O., Gorostiza,O., Peters-Libeu,C., Poksay,K.S., Matalis,A., Campagna,J., Patent,A., Rao,R., John,V., Bredesen,D.E. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Research 2014; 1551(-;-):25-44. >>> Tropisetron hydrochloride; donepezil; metamine; DMSO; saline; SC; Mice (transgenic); 1002; 14 days; 8 weeks; Controls received mp w/ vehicle; animal info (J20, 16-19 weeks old); functionality of mp verified by serum plasma; pumps replaced every 28 days; 25% DMSO used; comparison of oral delivery vs mp (fig.16, fig.17); neurodegenerative (Alzheimer's); stress/adverse reaction: (see pg.40); behavioral testing (Morris water maze;); "Brain levels were similar after pump and oral delivery. However, it is noteworthy that pump delivery is continuous, whereas the oral delivery was daily... " pg36;.

Q3360 Tan,M.S., Yu,J.T., Jiang,T., Zhu,X.C., Guan,H.S., Tan,L. IL12/23 p40 Inhibition Ameliorates Alzheimer's Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice. JOURNAL OF ALZHEIMERS DISEASE 2014; 38(-3-):633-646. >>> RNA, small interfering p40; CSF, artificial; CSF/CNS (third ventricle); Mice; 1004; 4 weeks; Controls received mp w/ control siRNA, aCSF, control antibody; animal info (male, SAMP8, SAMR1, 3 month, 7 month and 11 month old); functionality of mp verified by increased expression of IL-12 and IL-23; ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer); behavioral testing (Morris water maze);.

Q3262 Park,S., Kim,D.S., Kang,S., Moon,N.R. beta-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing beta-cell mass in non-diabetic and diabetic rats. METABOLISM-CLINICAL AND EXPERIMENTAL 2013; 62(-12-):1749-1760. >>> Amyloid protein, beta (25-35); amyloid protein, beta (35-25);; Saline; CSF/CNS (hippocampus); Rat; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 232g); neurodegenerative (Alzheimer's disease); behavioral testing (passive avoidance, morris water maze); diabetes induced with pancreatectomy; amyloid protein, beta (25-35) aka AMY or amyloid protein, beta (35-25) aka RAMY; bilateral infusion;.

Q3245 Montarolo,F., Parolisi,R., Hoxha,E., Boda,E., Tempia,F. Early Enriched Environment Exposure Protects Spatial Memory and Accelerates Amyloid Plaque Formation in APP(Swe)/PS1(L166P) Mice. PLoS One 2013; 8(-7-):U653-U666. >>> Tetrodotoxin; Saline; CSF/CNS (dorsal hippocampus); Mice (transgenic); 1004; 4 weeks; Controls received mp w/ vehicle; animal info (APP swe/PSI L166P, 2 months old); neurodegenerative (Alzheimer's); behavioral testing (Morris water maze, eight radial arm maze, escape latency); tissue perfusion (hippocampus); used dental cement to attach cannula; polyvinyl tubing.

Q3228 Zhang,Q.G., Wang,R.M., Scott,E., Han,D., Dong,Y., Tu,J.Y., Yang,F., Sareddy,G.R., Vadlamudi,R.K., Brann,D.W. Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 2013; 136(-;-):1432-1445. >>> Estradiol, 17b-; SC; Rat; 21 days; Controls received mp w/ placebo; animal info (female, 3 months old, Sprague Dawley, ovariectomized); neurodegenerative (Alzheimer's disease); behavioral testing (Morris Water Maze); replacement therapy (17beta estradiol after ovariectomy);.

Q3213 Dao,A.T., Zagaar,M.A., Salim,S., Eriksen,J.L., Alkadhi,K.A. Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2014; 17(-4-):593-602. >>> Amyloid, protein beta (1-42); Water, distilled; acetonitrile; trifluoroacetate; CSF/CNS; Rat; 2 weeks; Control animals received sham operation; animal info (adult, male, Wistar, 176-200 g); wound clips used; post op care (triple antibiotic); neurodegenerative (Alzheimer's disease).

Q3211 Nelson,A.R., Kolasa,K., McMahon,L.L. Noradrenergic Sympathetic Sprouting and Cholinergic Reinnervation Maintains Non-Amyloidogenic Processing of AbetaPP. JOURNAL OF ALZHEIMERS DISEASE 2014; 38(-4-):867-879. >>> Amyloid, protein beta; CSF/CNS (hippocampus); Rat; 14, 28 days; Animal info (Sprague-Dawley, 2-5 mo old, adult, male); Plastics One bilateral cannula used; neurodegenerative (Alzheimer's disease); bilateral infusion;.

Q3158 Sanganahalli,B.G., Herman,P., Behar,K.L., Blumenfeld,H., Rothman,D.L., Hyder,F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NEUROIMAGE 2013; 79(-;-):404-411. >>> Amyloid protein, beta (1-42); ferrus sulfate heptahydrate; L-Buthionine-(S,R)-sulfoximine; CSF/CNS; Rat; 4 weeks; Animal info (male, FAB/Samaritan Alzheimer's, 250-350g); neurodegenerative (Alzheimer's Disease); Pumps used to induce Alzheimer's disease symptoms in FAB rat models. Pump and cannula removed prior to MRI experiments.

Q3069 DeVos,S.L., Goncharoff,D.K., Chen,G., Kebodeaux,C.S., Yamada,K., Stewart,F.R., Schuler,D.R., Maloney,S.E., Wozniak,D.F., Rigo,F., Bennett,C.F., Cirrito,J.R., Holtzman,D.M., Miller,T.M. Antisense Reduction of Tau in Adult Mice Protects against Seizures. Journal of Neuroscience 2013; 33(-31-):12887-12897. >>> Tau, ASO-3; Oligonucleotides, antisense scrambled; Saline; CSF/CNS; Mice; 28 days; Controls received mp w/ vehicle; animal info (C57BL6J, Tao -/-); antisense (oligonucleotides); neurodegenerative (Alzheimer's Disease); behavioral testing (elevated plus maze, Morris water maze, seizure score); gene therapy; brain tissue distribution;.

Q2959 Han,X.J., Ma,Y., Liu,X.H., Wang,L., Qi,S., Zhang,Q.H., Du,Y.F. Changes in insulin-signaling transduction pathway underlie learning/memory deficits in an Alzheimer's disease rat model. Journal of Neural Transmission 2012; 119(-11-):1407-1416. >>> Amyloid protein, beta (1-42);; CSF/CNS; Rat; 1004; 1 month; Controls received mp w/ saline; animal info (Wistar); neurodegenerative (Alzheimer's disease); mp were used to infuse AB oligomers to study their effect on insulin signalling cascades and their role in memory and cognition loss in AD. Paper examines the importance of insulin transduction in preserving memory and learning. AB oligomers cause loss of Insulin receptor on neurons, or their downregulation;.

Q2953 Guo,J.J., Wang,J.N., Zhang,Z., Yan,J., Chen,M.M., Pang,T., Zhang,L.Y., Liao,H. proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus. Neurochemical Research 2013; 38(-8-):1695-1703. >>> Nerve growth factor, precursor;; PBS; BSA; Mice; 1007D; 7 Days; Animal info (10 week old, male, C57BL/6J, 21-25g); neurodegenerative (Alzheimer's disease).

Q2941 Streijger,F., Plunet,W.T., Lee,J.H.T., Liu,J., Lam,C.K., Park,S., Hilton,B.J., Fransen,B.L., Matheson,K.A.J., Assinck,P., Kwon,B.K., Tetzlaff,W. Ketogenic Diet Improves Forelimb Motor Function after Spinal Cord Injury in Rodents. PLoS One 2013; 8(-11-):U888-U906. >>> Cyano-4-hydroxycinnamate, alpha; Saline; SC; Rat; 1007D; ; Animal info (C5 hemi-contusion rat model, male, Sprague-Dawley, 350g); neurodegenerative (acute spinal cord injury, Alzheimer's, Epilepsy); behavioral testing (pg. 2, 3); Paper examines neuroprotective effect of ketogenic diet after spinal cord injury. Paper demonstrates this by blocking MCT transport via 4-CIN, which abolishes neuroprotection of KD.

Q2903 Colom,L.V., Castaneda,M.T., Aleman,D., Touhami,A. Memantine protects cholinergic and glutamatergic septal neurons from Abeta(1-40)-induced toxicity. Neuroscience Letters 2013; 541(-;-):54-57. >>> Memantine; SC; Rat; 2ML2; 8 days; Animal info (Sprague Dawley, 300-400g); neurodegenerative (Alzheimer's disease, dementia).

Q2742 Burke,R.M., Norman,T.A., Haydar,T.F., Slack,B.E., Leeman,S.E., Blusztajn,J.K., Mellott,T.J. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2013; 110(-48-):19567-19572. >>> Bone morphogenetic protein-9, human, recomb.; CSF/CNS; Mice; 1002; 7 days; Control animals received mp w/ vehicle; animal info (WT/CHGFP, APP.PS1/CHGFP, 5, 10 mo old, male, female); neurodegenerative (Alzheimer's disease).

Q2725 Feng,J.F., He,L.L., Li,D., Yuan,L.H., Yu,H.L., Ma,W.W., Yang,Y., Xi,Y.D., Ding,J., Xiao,Y.X., Xiao,R. Antagonizing Effects of Soybean Isoflavones on ss-Amyloid Peptide-Induced Oxidative Damage in Neuron Mitochondria of Rats. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2012; 111(-4-):248-253. >>> Amyloid protein, beta (1-42); PBS; CSF/CNS; Rat; 2002; 2 weeks; Control animals received mp w/ vehicle; animal info (Wistar, male, adult, 250-300 g); neurodegenerative (Alzheimer's disease).

Q2647 Rabinovich-Nikitin,I., Rakover,I.S., Becker,M., Solomon,B. Beneficial Effect of Antibodies against beta- Secretase Cleavage Site of App on Alzheimer's-Like Pathology in Triple-Transgenic Mice. PLoS One 2012; 7(-10-):U429-U437. >>> Antibody, monoclonal, BBS1; CSF, artificial; CSF/CNS; Mice (transgenic); 2004; 1 month; Control animals received mp w/ control antibody; animal info (17 mo old, 3xTg-AD); neurodegenerative (Alzheimer's disease).

Q2548 Attar,A., Ripoli,C., Riccardi,E., Maiti,P., Puma,D.D.L., Liu,T.Y., Hayes,J., Jones,M.R., Lichti-Kaiser,K., Yang,F.S., Gale,G.D., Tseng,C.H., Tan,M., Xie,C.W., Straudinger,J.L., Klaerner,F.G., Schrader,T., Frautschy,S.A., Grassi,C., Bitan,G. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain 2012; 135(-;-):3735-3748. >>> CLR01; Saline, sterile; SC; Mice (transgenic); 1004; 28 days; Control animals received mp w/ vehicle; animal info (triple transgenic, 14-15 mo old, male, female); CLR01 is an Lys-specific molecular tweezer; neurodegenerative (Alzheimer's disease).

Q2454 Sanchez,P.E., Zhu,L., Verret,L., Vossel,K.A., Orr,A.G., Cirrito,J.R., Devidze,N., Ho,K., Yu,G.Q., Palop,J.J., Mucke,L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012; 109(-42-):E2895-E2903. >>> Levetiracetam; Saline, sterile; SC; Mice; 2004; 28 days; Control animals received mp w/ vehicle; animal info (hAPPJ20, 4-6 mo old); neurodegenerative (Alzheimer's disease).

Q2412 Dhawan,G., Floden,A.M., Combs,C.K. Amyloid-beta oligomers stimulate microglia through a tyrosine kinase dependent mechanism. NEUROBIOLOGY OF AGING 2012; 33(-10-):2247-2261. >>> Dasatinib; oligomer, amyloid beta (1-42); HEPES; CSF/CNS; Mice; 1004; 14 days; Control animals received mp w/ vehicle; animal info (C57BL/6, female, 12 mo old); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); peptide; enzyme inhibitor (tyrosine kinase).

Q2409 vom Berg,J., Prokop,S., Miller,K.R., Obst,J., Kaelin,R.E., Lopategui-Cabezas,I., Wegner,A., Mair,F., Schipke,C.G., Peters,O., Winter,Y., Becher,B., Heppner,F.L. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature Medicine 2012; 18(-12-):1812-U229. >>> Antibody, P40; antibody, 2A3; CSF/CNS; Mice; 60 days; Animal info (APPPS1); long-term study; pumps replaced after 4 weeks; neurodegenerative (Alzheimer's disease).

Q2378 Ma,T., Du,X.L., Pick,J.E., Sui,G.Z., Brownlee,M., Klann,E. Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice. Journal of Neuroscience 2012; 32(-40-):13701-13708. >>> Glucagon-like peptide-1 (9-36), amide; Mice; 1002; 2 weeks; Animal info (APP/PS1, male, female, 12 mo old); behavioral testing (Morris water maze test); neurodegenerative (Alzheimer's disease).

Q2257 Wang,L.C., Wang,S.E., Wang,J.J., Tsai,T.Y., Lin,C.H., Pan,T.M., Lee,C.L. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid beta-protein-induced neurotoxicity and memory impairment. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2012; 94(-6-):1505-1519. >>> Amyloid protein, beta (40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (Wistar, male, 280-320 g); neurodegenerative (Alzheimer's disease).

Q2159 Rissman,R.A., Staup,M.A., Lee,A.R., Justice,N.J., Rice,K.C., Vale,W., Sawchenko,P.E. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012; 109(-16-):6277-6282. >>> R121919; Ethanol; cremaphor EL; Mice; 14 days; Animal info (CRFR KO, male, 15-22 wks old); antalarmin is a CRFR1 selective antagonist; comparison of IP injections vs mp; "Minipump delivery was the most effective technique" pg 6278; neurodegenerative (Alzheimer's disease); behavioral testing (restraint test).

Q2100 Dhawan,G., Combs,C.K. Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease. Journal of Neuroinflammation 2012; 9(-;-):U1-U17. >>> Dasatinib; DMSO; HEPES; SC; Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (female, APP/PS1, 13 mo old); neurodegenerative (Alzheimer's disease).

Q2094 Wang,H.Y., Bakshi,K., Frankfurt,M., Stucky,A., Goberdhan,M., Shah,S.M., Burns,L.H. Reducing Amyloid-Related Alzheimer's Disease Pathogenesis by a Small Molecule Targeting Filamin A. Journal of Neuroscience 2012; 32(-29-):9773-9784. >>> Amyloid protein, beta (42); CSF, artificial; CSF/CNS; Mice; 7 days; Controls received mp w/ vehicle; animal info (8 wks old, male, female E129, 30-35 g); neurodegenerative (Alzheimer's disease); infusion rate of 0.1 ul/hr.

Q2089 Yeh,C.H., Hsieh,M.T., Hsueh,C.M., Wu,C.R., Huang,Y.C., Liao,J.W., Chow,K.C. Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid beta (1-40)-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid beta. Evidence-based Complementary and Alternative Medicine 2012; ;(-;-):U1-U10. >>> Amyloid protein, beta (1-40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 21 days; Controls received mp w/ vehicle; animal info (Wistar, male, 200-250 g); behavioral testing (passive avoidance, Morris Water-maze); neurodegenerative (Alzheimer's disease).

Q1998 Peng,J., Liang,G., Inan,S., Wu,Z., Joseph,D.J., Meng,Q.C., Peng,Y., Eckenhoff,M.F., Wei,H.F. Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neuroscience Letters 2012; 516(-2-):274-279. >>> Dantrolene; DMSO; PBS; CSF/CNS; Mice (transgenic); 1004; 90 days; Controls received mp w/ vehicle; animal info (3xTg-AD, 2 mo old); 25% DMSO used; pumps replaced after 1 month; long-term study; adverse effects, significant mortality in drug and vehicle group "when they underwent surgery for the Alzet pump replacement, primarily during the anesthetic induction. Excess mortality in this transgenic animal has been documented before..." pg 278; neurodegenerative (Alzheimer's disease).

Q1820 Yuan,L.H., Zhou,X., Li,D., Ma,W.W., Yu,H.L., Xi,Y.D., Xiao,R. Pattern recognition receptors involved in the inflammatory attenuating effects of soybean isoflavone in beta-amyloid peptides 1-42 treated rats. Neuroscience Letters 2012; 506(-2-):266-270. >>> Amyloid protein, beta (1-42); Saline, physiological; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Wistar, male, 250-300 g); neurodegenerative (Alzheimer's disease).

Q1769 Lee,Y.K., Choi,I.S., Ban,J.O., Lee,H.J., Lee,U.S., Han,S.B., Jung,J.K., Kim,Y.H., Kim,K.H., Oh,K.W., Hong,J.T. 4-O-methylhonokiol attenuated beta-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2011; 22(-5-):476-486. >>> Amyloid protein, beta (1-42); Saline, sterile; CSF/CNS; Mice; 2001; 14 days; Control animals were untreated; animal info (Slc:ICR); neurodegenerative (Alzheimer's disease).

Q1761 Ding,B.J., Ma,W.W., He,L.L., Zhou,X., Yuan,L.H., Yu,H.L., Feng,J.F., Xiao,R. Soybean isoflavone alleviates beta-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-kappaB activity in rats. International Journal of Developmental Neuroscience 2011; 29(-5-):537-542. >>> Amyloid protein, beta (1-42); PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (Wistar, male, adult, 250-300 g); cannula placement verified via injecting ink ICV; neurodegenerative (Alzheimer's disease).

Q1753 Tran,T.T., Srivareerat,M., Alkadhi,K.A. Chronic Psychosocial Stress Accelerates Impairment of Long-Term Memory and Late-Phase Long-Term Potentiation in an At-Risk Model of Alzheimer's Disease. Hippocampus 2011; 21(-7-):724-732. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ beta amyloid (42-1); animal info (Wistar, male, 200-225 g); 14-day pump used; peptides; neurodegenerative (Alzheimer's disease).

Q1667 Allard,S., Leon,W.C., Pakavathkumar,P., Bruno,M.A., Ribeiro-da-Silva,A., Cuello,A.C. Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype. Journal of Neuroscience 2012; 32(-6-):2002-2012. >>> Antiplasmin, alpha-2; MMP2-9I, type 1; Saline; sodium acetate; DMSO; CSF/CNS (medial prefrontal cortex); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Wistar, male, 350 g); Plastics One bilateral cannula used; 1% DMSO used; enzyme inhibitor (matrix metalloproteinase); behavioral testing (water maze test); neurodegenerative (Alzheimer's disease); bilateral infusion;.

Q1573 Bitner,R.S., Bunnelle,W.H., Decker,M.W., Drescher,K.U., Kohlhaas,K.L., Markosyan,S., Marsh,K.C., Nikkel,A.L., Browman,K., Radek,R., Anderson,D.J., Buccafusco,J., Gopalakrishnan,M. In Vivo Pharmacological Characterization of a Novel Selective alpha-7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease. Journal of Pharmacology and Experimental Therapeutics 2010; 334(-3-):875-886. >>> ABT-107; donepezil; SC; Rat; mice; 1002; 2ML2; 7 days; 2 weeks; animal info (Sprague Dawley, male, 275-400 g; male CD1, female tau P301L, 20-30 g); post op. care (flunixin meglumine); wound clips used; neurodegenerative (Alzheimer's disease).

Q1516 Schaeffer,E.L., Skaf,H.D., Novaes,B.D., da Silva,E.R., Martins,B.A., Joaquim,H.D.G., Gattaz,W.F. Inhibition of phospholipase A(2) in rat brain modifies different membrane fluidity parameters in opposite ways. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2011; 35(-7-):1612-1617. >>> MAFP; DMSO; NaCl; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (male, Wistar, 270-330 g); 3% DMSO used; MAFP also known as methyl arachidonyl fluorophosphonat, is a dual inhibitor of both cPLA2 and iPLA2; guide cannula used; enzyme inhibitor (phospholipase A2, calcium-dependent cytosolic phospholipase A2); neurodegenerative (Alzheimer's disease).

Q1466 Zara,S., Rapino,M., Sozio,P., Di Stefano,A., Nasuti,C., Cataldi,A. Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C epsilon-mediated metalloproteinase 2 and 9 levels in beta-amyloid infused Alzheimer's disease rat model. Brain Research 2011; 1412(-;-):79-87. >>> Amyloid protein, beta (1-40); Saline, sterile; acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Wistar, 200-225 g); peptides; ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease).

Q1354 Teng,E., Kepe,V., Frautschy,S.A., Liu,J., Satyamurthy,N., Yang,F.S., Chen,P.P., Cole,G.B., Jones,M.R., Huang,S.C., Flood,D.G., Trusko,S.P., Small,G.W., Cole,G.M., Barrio,J.R. [F-18]FDDNP microPET imaging correlates with brain Abeta burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-A beta antibody treatment. NEUROBIOLOGY OF DISEASE 2011; 43(-3-):565-575. >>> Antibody, anti-A-beta 1-16; PBS; CSF/CNS; Rat; 1004; 4 weeks; Controls received mp w/ control antibody; brain tissue distribution; animal info (17-18 mo old, Tg); antibody also known as 6E10; neurodegenerative (Alzheimer's disease).

Q1330 Sotiropoulos,I., Catania,C., Pinto,L.G., Silva,R., Pollerberg,G.E., Takashima,A., Sousa,N., Almeida,O.F.X. Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits. Journal of Neuroscience 2011; 31(-21-):7840-7847. >>> Amyloid protein, beta (1-40); Water, sterile, distilled; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Wistar, 14 mo old); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); behavioral testing (Morris water maze); "We infused A beta 1-40 rather than the more pathogenic A beta 1-42 species because the former aggregates less readily" pg 7841.

Q1329 Sozio,P., D'Aurizio,E., Iannitelli,A., Cataldi,A., Zara,S., Cantalamessa,F., Nasuti,C., Di Stefano,A. Ibuprofen and Lipoic Acid Diamides as Potential Codrugs with Neuroprotective Activity. Archiv der Pharmazie 2010; 343(-3-):133-142. >>> Amyloid protein, beta (1-40); Saline, sterile; CSF/CNS; Rat; 2004; 28 days; Animal info (male, Wistar, 200-225 g); neurodegenerative (Alzheimer's disease).

Q1205 Li,Y.Z., Duffy,K.B., Ottinger,M.A., Ray,B., Bailey,J.A., Holloway,H.W., Tweedie,D., Perry,T., Mattson,M.P., Kapogiannis,D., Sambamurti,K., Lahiri,D.K., Greig,N.H. GLP-1 Receptor Stimulation Reduces Amyloid-beta Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 2010; 19(-4-):1205-1219. >>> Exendin-4; Saline; SC; Mice (transgenic); 1004; 16 weeks; Controls received mp w/ vehicle; long-term study; animal info (3xTgAD, male, female, 11-12.5 mo old); pumps replaced every 4 weeks; neurodegenerative (Alzheimer's Disease).

Q1115 Hashimoto,M., Tozawa,R., Katakura,M., Shahdat,H., Haque,A.M., Tanabe,Y., Gamoh,S., Shido,O. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid beta-infused rats. FOOD&FUNCTION 2011; 2(-7-):386-394. >>> Amyloid protein, beta (1-40); CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Wistar); peptides; neurodegenerative (Alzheimer's disease).

Q1111 Hafez,D., Huang,J.Y., Huynh,A.M., Valtierra,S., Rockenstein,E., Bruno,A.M., Lu,B., DesGroseillers,L., Masliah,E., Marr,R.A. Neprilysin-2 Is an Important beta-Amyloid Degrading Enzyme. American Journal of Pathology 2011; 178(-1-):306-312. >>> Phosphoramidon; Saline; ascorbic acid; CSF/CNS; Mice; 1007D; ; Controls received mp w/ vehicle; animal info (NEP/NEP2 DKO); enzyme inhibitor (neprilysin); neurodegenerative (Alzheimer's disease); incorrectly listed Model 1007.

Q1080 Garcia-Matas,S., de Vera,N., Aznar,A.O., Marimon,J.M., Adell,A., Planas,A.M., Cristofol,R., Sanfeliu,C. In Vitro and In Vivo Activation of Astrocytes by Amyloid-beta is Potentiated by Pro-Oxidant Agents. JOURNAL OF ALZHEIMERS DISEASE 2010; 20(-1-):229-245. >>> Protein, amyloid beta (40-1); protein, amyloid beta (42-1); buthionine sulfoximine; ferrous sulfate; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (3 mo old, male, Sprague Dawley, 300-350 g); functionality of mp verified; multiple pumps per animal (2); neurodegenerative (Alzheimer's disease).

Q0891 MacMillan,K.S., Naidoo,J., Liang,J., Melito,L., Williams,N.S., Morlock,L., Huntington,P.J., Estill,S.J., Longgood,J., Becker,G.L., McKnight,S.L., Pieper,A.A., De Brabander,J.K., Ready,J.M. Development of Proneurogenic, Neuroprotective Small Molecules. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011; 133(-5-):1428-1437. >>> P7C3; analogue, P7C3; fibroblast growth factor-2; DMSO; cremophor EL; dextrose; water; CSF/CNS; Mice; 1007D; 7 days; Positive controls received mp w/ FGF-2; animal info (12 week old, C57BL/J6); neurodegenerative (Alzheimer's disease); 3% DMSO used.

Q0861 Chang,W.P., Huang,X.P., Downs,D., Cirrito,J.R., Koelsch,G., Holtzman,D.M., Ghosh,A.K., Tang,J. beta-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB Journal 2011; 25(-2-):775-784. >>> GRL-8234; PEG 300; glucose; SC; Mice (transgenic); 1002; 5-7.5 months; Controls received mp w/ vehicle; animal info (Tg2576); long-term study; pumps replaced after 21 days; enzyme inhibitor (beta-secretase); neurodegenerative (Alzheimer's disease).

Q0810 Zhang,Z., Simpkins,J.W. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Research 2010; 1359(-;-):233-246. >>> Okadaic acid; DMSO; CSF, artificial; CSF/CNS (right dorsal hippocampus); Rat; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (adult, Sprague Dawley, ovariectomized); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); 1% DMSO used.

Q0733 Murphy,K.J., Miller,A.M., Thelma,R., Cowley,F., Cox,F.F., Lynch,M.A. The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation. NEUROCHEMISTRY INTERNATIONAL 2011; 58(-2-):161-168. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); CSF/CNS; Rat; 2004; 8 days; Controls received mp w/ reverse peptide 40-1; animal info (Wistar, male, 3 mo old, 250-350 g, 22 mo old, 550-650 g); peptides; ALZET brain infusion kit II used; neurodegenerative (Alzheimer's disease).

Q0731 Bitner,R.S., Markosyan,S., Nikkel,A.L., Brioni,J.D. In-vivo histamine H(3) receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease. Neuropharmacology 2011; 60(-2-3-):460-466. >>> ABT-239; Water; SC; Mice (transgenic); 1002; 2 weeks; Controls received mp w/ sterile water; animal info (Male CD1, Tg2576, female TAPP, 20-30 g); neurodegenerative (Alzheimer's disease).

Q0716 Pabon,M.M., Bachstetter,A.D., Hudson,C.E., Gemma,C., Bickford,P.C. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of Neuroinflammation 2011; 8(-;-):U1-U7. >>> CX3CL1; fractaline, heat inactivated; CSF/CNS (striatum); Rat; 2004; 28 days; Controls received mp w/ fractaline; animal info (Fisher 344, 3 mo old, male); neurodegenerative (Parkinson disease, Alzheimer disease).

Q0598 Ittner,L.M., Ke,Y.D., Delerue,F., Bi,M.A., Gladbach,A., van Eersel,J., Woelfing,H., Chieng,B.C., Christie,M.J., Napier,I.A., Eckert,A., Staufenbiel,M., Hardeman,E., Goetz,J. Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell 2010; 142(-3-):387-397. >>> TAT-NR2B9c; CSF, artificial; CSF/CNS; Mice; 1004; 56 days; Negative controls received mp w/ Tat-NR2BAA; animal info (6 wks old, APP23, WT); long-term study; pumps replaced after 28 days; ALZET brain infusion kit 3 (with one spacer) used; peptides; neurodegenerative (Alzheimer's Disease).

Q0505 Amaral,F.A., Lemos,M.T.R., Dong,K.E., Bittencourt,M.F.Q.P., Caetano,A.L., Pesquero,J.B., Viel,T.A., Buck,H.S. Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice. Neuropeptides 2010; 44(-2-):93-97. >>> Amyloid protein, beta (1-40); E-64; HEPES; CSF/CNS; Mice; 1004; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (cystein protease); ALZET brain infusion kit 3 used; animal info (male, C57BL/6, wt, KOB1 KOB2, 28031 g, 12 wks old); behavioral testing (active avoidance); neurodegenerative (Alzheimer's Disease); "infusion (of beta-amyloid protein) could provide a tissue response closer to that observed in the pathogenesis of AD." pg 94.

Q0500 Tran,T.T., Srivareerat,M., Alkadhi,K.A. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 2010; 37(-3-):756-763. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta (42-1); peptides; animal info (Wistar, 200-225 g); 14-day pump used; neurodegenerative (Alzheimer's Disease).

Q0427 Li,W.D., Wu,Y., Min,F.G., Li,Z., Huang,J.Y., Huang,R. A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-beta42 and thiorphan. METABOLIC BRAIN DISEASE 2010; 25(-3-):277-284. >>> Thiorphan; Saline; ascorbic acid; CSF/CNS (basal ganglia); Monkey; 2ML4; 28 days; Controls received mp w/saline; animal info (middle aged, rhesus, male, 16-17 years old); neurodegenerative (Alzheimer's disease).

Q0414 Hong,H.S., Maezawa,I., Budamagunta,M., Rana,S., Shi,A.B., Vassar,R., Liu,R.W., Lam,K.S., Cheng,R.H., Hua,D.H., Voss,J.C., Jin,L.W. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. NEUROBIOLOGY OF AGING 2010; 31(-10-):1690-1699. >>> K01-162; K01-182; DMSO; CSF, artificial; CSF/CNS; Mice (transgenic); 1002; 2 weeks; Controls received mp w/ vehicle; animal info (Tg6799 5xFAD, 3 months old); neurodegenerative (Alzheimer's disease); K01-162 and K01-186 are fluorene compounds from libraries of amyloid ligands.

Q0398 Alkadhi,K.A., Srivareerat,M., Tran,T.T. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 45(-3-):289-296. >>> Amyloid protein, beta (1-40); amyloid protein, beta 1-42; Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta non-pathogenic reverse peptide; animal info (adult, male, Wistar, 200-225 g); neurodegenerative (Alzheimer's disease).

Q0252 Shinohara,M., Sato,N., Kurinami,H., Takeuchi,D., Takeda,S., Shimamura,M., Yamashita,T., Uchiyama,Y., Rakugi,H., Morishita,R. Reduction of Brain beta-Amyloid (A-beta) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and A-beta Clearance. Journal of Biological Chemistry 2010; 285(-29-):22091-22102. >>> Leupeptin; E-64a; CSF, artificial; CSF/CNS; Mice (transgenic); 2002; 1 week; Controls received mp w/ vehicle; peptides; ALZET brain infusion kit 3 used; no stress (see pg 22092); neurodegenerative (Alzheimer's Disease); animal info (male, C57BL/6, APP23 Tg, 8 wks old); lysosomal inhibitor; aCSF recipe.

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3. Amyotrophic Lateral Sclerosis

16183 Solomonov, Y., Hadad, N., Levy, R. Reduction of cytosolic phospholipase A2alpha upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis. J Neuroinflammation 2016; 13(-1-):134. >>> Oligonucleotide, antisense anti-Cytosolic phospholipase A2 alpha; Saline; CSF/CNS; Mice (transgenic); Controls received mp w/ vehicle; animal info (male, B6.Cg-Tg(SOD1G93A)1Gur/J hemizygous transgenic, 10 weeks old, 25 g); ALZET brain infusion kit 3 used; antisense (oligonucleotide anti-Cytosolic phospholipase A2 alpha); neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (rotarod test; ladder testing); pumps primed overnight in 37C saline; Dose (10 ug/day); Brain coordinates (right lateral cerebral ventricle (−1.0 mm mediolateral and −0.5 mm anteroposterior from Bregma));.

16162 Ramirez-Jarquin, U. N., Tapia, R. Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo. Neuroscience 2016; 331(--):78-90. >>> AMPA; Phosphate buffer; CSF/CNS (intrathecal); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 270-300g); neurodegenerative (amyotrophic lateral sclerosis); post op. care (IM penicillin); behavioral testing (rotarod, paw grip endurance; stride analysis); AMPA aka a-amino-3- hydroxy-5-methyl-4-isoxazoleacetic acid; pumps primed for 48 hours in 37C saline; used surgical clips;.

16012 Ghadge, G. D., Pavlovic, J. D., Koduvayur, S. P., Kay, B. K., Roos, R. P. Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1. Neurobiol Dis 2013; 56(--):74-8. >>> antibody, monoclonal anti-SOD1; CSF/CNS (ventricles); mice; animal info: FALS transgenic mice; anti SOD1 monoclonal antibody; neurodegenerative (Amyotrophic Lateral Sclerosis); paper does not mention ALZET much, or pump model;.

15893 Vieira, F. G., Ping, Q., Moreno, A. J., Kidd, J. D., Thompson, K., Jiang, B., Lincecum, J. M., Wang, M. Z., De Zutter, G. S., Tassinari, V. R., Levine, B., Hatzipetros, T., Gill, A., Perrin, S. Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLoS One 2015; 10(-8-):e0135570. >>> Guanabenz acetate; Ethanol; water; propylene glycol; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (SOD1-G93A); pumps replaced every 28 days; dose-response (pg 4); neurodegenerative (amyotrophic lateral sclerosis); post op. care (antibiotic ointment; buprenorphine 0.1 mg/kg); long-term study; used lot#10284-12; Dose (0.45, 1.5, or 4.5 mg/kg/day);.

15871 Ruban, A., Malina, K. C., Cooper, I., Graubardt, N., Babakin, L., Jona, G., Teichberg, V. I. Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. Neurodegener Dis 2015; 15(-4-):233-42. >>> Kanic acid; cyclothiazide; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; animal info (male, Wistar, 8-9 weeks old, 240-250g); pumps replaced every week; neurodegenerative (ALS amyotrophic lateral sclerosis); behavioral testing (rotarod testing); pumps primed in 37C sterile saline overnight; catheter placement verified by visual examination;.

15796 Dusan Matusica, Fabienne Alfonsi, Bradley J. Turner, Tim J. Butler, Stephanie R. Shepheard, Mary-Louise Rogers, Sune Skeldal, Clare K. Underwood, Marie Mangelsdorf, Elizabeth J. Coulson. Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment. Journal of Cell Science 2016; 129(--):517-530. >>> Peptide, c29; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (SOD G93A, 9 weeks old); pumps replaced every month until death; neurodegenerative (amyotrophic lateral sclerosis); neurodegenerative (amyotrophic lateral sclerosis); long-term study; peptides; Dose (5 mg/kg/day);.

15767 Mathieu Gravel, Louis-Charles Beland, Genevieve Soucy, Essam Abdelhamid, Reza Rahimian, Claude Gravel, Jasna Kriz. IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1. The Journal of Neuroscience 2016; 36(-3-):1031-1048. >>> Antibody, Interleukin-10 receptor; Antibody, Interleukin-10 receptor; Mice; 2006; Controls received mp w/ saline; animal info (SOD1 G93A, 60 days old); neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (hindlimb relfex); pumps primed overnight in 37C saline; used dental cement; Dose (3.6 ug/day);.

15713 Ghanashyam D. Ghadge, John D. Pavlovic,, Sujatha P. Koduvayur,, Brian K. Kay,, Raymond P. Roos. Single chain variable fragment antibodies block aggregation and toxicity induced byfamilial ALS-linked mutant forms of SOD1. NEUROBIOLOGY OF DISEASE 2013; 56(--):74-78. >>> anti-SOD1 monoclonal antibodies (mAbs); CSF/CNS (intraventricular); mice; not specified; FALS transgenic mice; anti SOD1 monoclonal antibody; neurodegenerative (Amyotrophic Lateral Sclerosis); paper does not mention ALZET much, or pump model..

14840 Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Nicoletti, F., Bruno, V., Bruno, V. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 2015; 74(--):126-136. >>> LY379268; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J or SOD1G93A, 8 weeks old, 20-22g); pumps replaced every 28 days; neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (rotarod testing); immunology;.

14508 Yin, H.Z., Yu, S., Hsu, C.I., Liu, J., Acab, A., Wu, R., Tao, A.N., Chiang, B.J., Weiss, J.H., Weiss, J.H. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Experimental Neurology 2014; 261(--):1-9. >>> Propanoic acid, amino-beta-methyl; CSF/CNS (intrathecal); Rat (transgenic); 2004; Controls received mp w/ saline; animal info (male, hemizygous SOD1 G93A, 80 days old); neurodegenerative (amyotrophic lateral sclerosis ); toxicology; amino-beta-methylaminopropanoic acid aka beta-N-methylamino-L-alanine aka BMAA; BMAA is a neurotoxin; used PE5 catheter for IT cannulation;.

14282 Liu, Y.J., Ju, T.C., Chen, H.M., Jang, Y.S., Lee, L.M., Lai, H.L., Tai, H.C., Fang, J.M., Lin, Y.L., Tu, P.H., Chern, Y.J., Chern, Y.J. Activation of AMP-activated protein kinase alpha1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human Molecular Genetics 2015; 24(--):787-801. >>> JMF1907; Saline; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (B6SJL-Tg, 6 weeks old); pumps replaced every 4 weeks; neurodegenerative (Amyotrophic lateral sclerosis); no stress (see pg. 792); behavioral testing (rotarod, forelimb grip); long-term study;.

13854 Oono, M., Okado-Matsumoto, A., Shodai, A., Ido, A., Ohta, Y., Abe, K., Ayaki, T., Ito, H., Takahashi, R., Taniguchi, N., Urushitani, M. Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. Journal of Neurochemistry 2014; 128(-3-):403-418. >>> Cystamine; CSF/CNS (intrathecal); Mice; 2006; Controls received mp w/ vehicle; animal info (WT C57BL6 or mSOD1, 30 weeks old); neurodegenerative (amyotrophic lateral sclerosis); immunology; stability"Cystamine hydrochloride has previously been shown to be very stable for long time use in the osmotic minipump"pg 417; long-term study;.

13647 Koval, E.D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B.N., Wu, G.F., Miller, T.M. Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice. Human Molecular Genetics 2013; 22(-20-):4127-4135. >>> Antagomir, miR-155; Saline; CSF/CNS; Mice; 2004; 2006; Controls received mp w/ saline or control mi-RNA; animal info (C571BL6); antisense (oligonucleotide); neurodegenerative (ALS - Amyotrophic Lateral Sclerosis); long-term study;.

13217 DeVos, S.L., Miller, T.M. Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA. Neurotherapeutics 2013; 10(-3-):486-497. >>> Oligonucleotide, antisense, ASO; SC; Rat; Neurodegenerative (Parkinson's, Huntington, amyotrophic lateral sclerosis); paper only references ALZET. Paper provides a starting guide for designing basic ASO sequences (Fig. 4).

12690 Van Hoecke, A., Schoonaert, L., Lemmens, R., Timmers, M., Staats, K.A., Laird, A.S., Peeters, E., Philips, T., Goris, A., Dubois, B., Andersen, P.M., Al-Chalabi, A., Thijs, V., Turnley, A.M., van Vught, P.W., Veldink, J.H., Hardiman, O., Van den Bosch, L., Gonzalez-Perez, P., Van Damme, P., Brown, RH Jr, van den Berg, L.H., Robberecht, W. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nature Medicine 2012; 18(-9-):1418-U168. >>> KYLPYWPVLSSL; CSF, artificial; CSF/CNS; Rat; 2004; Animal info (60 days old, female); KYLPYWPVLSSL is a Epha4 blocking peptide; peptides; neurodegenerative (amyotrophic lateral sclerosis);.

12305 Li, Y.Z., Chigurupati, S., Holloway, H.W., Mughal, M., Tweedie, D., Bruestle, D.A., Mattson, M.P., Wang, Y., Harvey, B.K., Ray, B., Lahiri, D.K., Greig, N.H. Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis. PLoS One 2012; 7(-2-):U436-U448. >>> Exendin-4; Saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (SOD1, G93A, 6 wks old); pumps replaced every 3 weeks; long-term study; neurodegenerative (amyotrophic lateral sclerosis);.

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4. Ataxia Telangiectasia

11341 Foster, C.R., Singh, M., Subramanian, V., Singh, K. Ataxia telangiectasia mutated kinase plays a protective role in beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling. MOLECULAR AND CELLULAR BIOCHEMISTRY 2011; 353(-1-2-):13-22. >>> Isoproterenol, l-; SC; Mice; Animal info (4 mo old, male, female, wt, hKO).

6667 Browne, S.E., Roberts, LJ II, Dennery, P.A., Doctrow, S.R., Beal, M.F., Barlow, C., Levine, R.L. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radical Biology and Medicine 2004; 36(-7-):938-942. >>> EUK-189; Mannitol; SC; Mice; 2004; Controls received mp w/ vehicle; long-term study; pumps replaced every 28 days; no stress (see pg.941); cancer (thymoma); EUK-189 is a synthetic catalytic antioxidant w/ both catalase&superoxide dismutase activities; neurodegenerative (ataxia telangiectasia).

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5. Huntington's Disease

16149 Pan, Y., Daito, T., Sasaki, Y., Chung, Y. H., Xing, X., Pondugula, S., Swamidass, S. J., Wang, T., Kim, A. H., Yano, H. Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Sci Rep 2016; 6(--):31022. >>> Cytidine, fluorodeoxy-; Saline; CSF/CNS; Mice; 2001; ALZET brain infusion kit 3 used; neurodegenerative (Huntington’s disease); stability verified by (“…FdCYd fully maintained its neuroprotective activity after 45 days of pre-incubation” see supplement 2); “…decitabine and FdCyd, are known to be degraded rapidly by cytidine deaminase in the liver (in vivo half life of decitabine<20 min)62, indicating that systemic administration may not be an effective strategy for drug delivery to the brain. We therefore chose intracerebroventricular (icv) administration using an Alzet osmotic pump, which provides continuous infusion of drug at a consistent rate from a subcutaneous pump” pg 8; FdCyd aka Cytidine, fluorodeoxy-; decitabine and FdCyd are similar in structure.

15844 Jun Wu,, Daniel A. Ryskamp,, Xia Liang, Polina Egorova,, Olga Zakharova,, Gene Hung,, Ilya Bezprozvanny. Enhanced Store-Operated Calcium Entry Leads to StriatalSynaptic Loss in a Huntington’s Disease Mouse Model. The Journal of Neuroscience 2016; 36(-1-):125-141. >>> EVP4593; DMSO; PEG 300; CSF/CNS; Mice (transgenic); 2006; Controls received mp w/ vehicle; animal info (YAC128 or WT, 10.5 months old); 10% DMSO used; neurodegenerative (Huntington's disease);.

15819 Analyne M. Schroeder, Huei Bin Wang, Saemi Park, Maria C. Jordan, Fuying Gao, Giovanni Coppola, Michael C. Fishbein, Kenneth P. Roos, Cristina A. Ghiani, Christopher S. Colwell. Cardiac Dysfunction in the BACHD MouseModel of Huntington’s Disease. PLoS One 2016; 11(-1-):1-25. >>> Isoproterenol; Saline; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (BACHD or WT, 2-3 months old); neurodegenerative (Huntington's Disease); long-term study; cardiovascular; Dose (0.24, 0.48, 0.97 mg/day);.

15745 Jianfang Chen,, Eileen Marks,, Barry Lai,, Zhaojie Zhang,, James A. Duce,, Linh Q. Lam,, Irene Volitakis,, Ashley I. Bush,, Steven Hersch,, Jonathan H. Fox. Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine. plos one 2013; 8(-10-):1-12. >>> Deferoxamine; CSF/CNS; Mice; 1002; 6 wk old, R6/2 HD mice; neurodegenerative (Huntington's disease); mp was used to infuse Deferoxamine, an iron chelator, in Huntington's patietns; 1 nmole/hr;.

15741 Ilaria Ceccarelli,, Pasquale Fiengo,, Rosaria Remelli,, Vincenzo Miragliotta,, Lara Rossini,, Irene Biotti,, Alessandra Cappelli,, Lara Petricca,, Salvatore La Rosa,, Andrea Caricasole,, Giuseppe Pollio,, Carla Scali. Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery. NEUROBIOLOGY OF DISEASE 2016; (-86-):41-51. >>> Cystamine dihydrochloride; Dulbecco's PBS; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Wistar, 175-200g); neurodegenerative (Huntington's disease); Dose (100 mg/Kg/day);.

15276 Jianfang Chen,, Eileen Marks, Barry Lai,, Zhaojie Zhang,, James A. Duce,, Linh Q. Lam,, Irene Volitakis,, Ashley I. Bush,, Steven Hersch,, Jonathan H. Fox. Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine. PLoS One 2013; 8(-10-):12. >>> deferoxamine; CSF/CNS (left lateral ventricle); mice; 1002; 6 wk old, R6/2 HD mice; neurodegenerative (Huntington's disease); dose: 1 nmole/hr.

14813 Aharony, I., Ehrnhoefer, D.E., Shruster, A., Qiu, X.F., Franciosi, S., Hayden, M.R., Offen, D., Offen, D. A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits. HUMAN MOLECULAR GENETICS 2015; 24(--):2604-2614. >>> ED11; Saline; water, sterile; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (5 weeks old); animal info (5 weeks old); neurodegenerative (Huntington's disease); behavioral testing (rotarod test, forced swim test, open field test, light dark choice test); long-term study; peptides; enzyme inhibitor (caspase-6);.

14233 Ju, T.C., Chen, H.M., Chen, Y.C., Chang, C.P., Chang, C., Chern, Y.J., Chern, Y.J. AMPK-alpha1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014; 1842(--):1668-1680. >>> AICAR; CSF/CNS (striatum); Mice; Animal info (R6/2 or Hdh150Q); neurodegenerative (Huntington's disease);.

14593 Doria, J.G., de Souza, J.M., Andrade, J.N., Rodrigues, H.A., Guimaraes, I.M., Carvalho, T.G., Guatimosim, C., Dobransky, T., Ribeiro, F.M., Ribeiro, F.M. The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease. NEUROBIOLOGY OF DISEASE 2015; 73(--):163-173. >>> CDPPB; DMSO; SC; Mice; 2006; Control animals received mp w/ vehicle; animal info (FVB/NJ, FVB/N-Tg); long-term study; CDPPB is a mGluR5 PAM, a metabotropic glutamate receptor 5 positive allosteric modulator; neurodegenerative disease (Huntington's disease).

13807 Hsiao, H.Y., Chiu, F.L., Chen, C.M., Wu, Y.R., Chen, H.M., Chen, Y.C., Kuo, H.C., Chern, Y., Chern, Y. Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease. Human Molecular Genetics 2014; 23(--):4328-4344. >>> XPro1595; CSF/CNS; Mice; 2004; Controls received mp w/ saline; animal info (WT or R62, 7.5-11.5 weeks old); ALZET brain infusion kit 3 used; comparison of IP injections vs mp ICV infusion; neurodegenerative (Huntington's disease); behavioral testing (rotarod performance, beam walking, foot clasping, t-maze);"Our data also showed that an i.p. injection of XPro1595 further decreased theBW of R6/2 mice, whereas an i.c.v. infusion of a dominant negative inhibitor of soluble TNF-a (XPro1595) did not affect the BW... i.c.v. delivery of XPro1595 appeared to be safer and more effective for treating HD."pg 4334; XPro1595 is a selective inhibitor of solTNF;.

13703 Anglada-Huguet, M., Xifro, X., Giralt, A., Zamora-Moratalla, A., Martin, E.D., Alberch, J. Prostaglandin E2 EP1 Receptor Antagonist Improves Motor Deficits and Rescues Memory Decline in R6/1 Mouse Model of Huntington's Disease. MOLECULAR NEUROBIOLOGY 2014; 49(-2-):784-795. >>> SC-51089; Water; IP; Mice (transgenic); 1004; 1002; Controls received mp w/ vehicle; animal info (male, R6/1, 13 weeks old); neurodegenerative (Huntington's disease); behavioral testing (clasping; rotarod apparatus; balance beam; vertical pole; novvel object recognition; t-maze spontaneous alternation task);"SC-51089 treatment reduced drastically the volume of striatal lesion induced by QUIN injection (62.3 %; Fig. 1),demonstrating that SC-51089 mini-osmotic pump deliver system exerts a neuroprotective role"pg 787; SC-51089 is an EP1 receptor antagonist.

13488 Guo, X., Disatnik, M.H., Monbureau, M., Shamloo, M., Mochly-Rosen, D., Qi, X. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. Journal of Clinical Investigation 2013; 123(-12-):5371-5388. >>> P110-TAT; SC; Mice (transgenic); Controls received mp w/TAT control peptide; animal info (R6/2 HD model, 5 weeks old); functionality of mp verified by FITC positive signal in neurons pg 5379; pumps replaced every 28 days; neurodegenerative (Huntington's disease); no stress (see pg.5381, 5383); behavioral testing (motor function and behaviors); stability verified by (HPLC with UV detection for 28 days); long-term study; peptides; P110-TAT is a Drp1-selective peptide inhibitor.

13217 DeVos, S.L., Miller, T.M. Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA. Neurotherapeutics 2013; 10(-3-):486-497. >>> Oligonucleotide, antisense, ASO; SC; Rat; Neurodegenerative (Parkinson's, Huntington, amyotrophic lateral sclerosis); paper only references ALZET. Paper provides a starting guide for designing basic ASO sequences (Fig. 4).

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6. Multiple Sclerosis

15832 Yasir A. Syed, Chao Zhao, Don Mahad, Wiebke Möbius, Friedrich Altmann, Franziska Foss, Aycan Sentürk, Amparo Acker‑Palmer, Gert Lubec, Kathryn Lilley, Robin J. M. Franklin, Klaus‑A. Nave, Mark R. N. Kotter. Antibody‑mediated neutralization of myelin‑associated EphrinB3accelerates CNS remyelination. Acta Neuropathol. (Berl) 2016; 131(--):281-298. >>> Fc-IgG; ephrineB3, pre-clustered; PBS; CSF/CNS (caudal cerebellar peduncle); Rats; mice; Controls received mp w/ Fc-IgG only; animal info (Rats - female, Sprague Dawley; mice - EphrinB3 KO); neurodegenerative (multiple sclerosis); tissue perfusion (caudal cerebellar peduncle); Cannula placement verified via infusion of Evan's Blue;.

14479 Williams, J.L., Patel, J.R., Daniels, B.P., Klein, R.S., Klein, R.S. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. Journal of Experimental Medicine 2014; 211(--):791-799. >>> AMD3100; Saline; Mice; Controls received mp w/ vehicle or no mp; animal info (male, C57BL6J or CXCR7 GFP/+, 8 weeks old); neurodegenerative (multiple sclerosis); cardiovascular;.

14390 Schweingruber, N., Fischer, H.J., Fischer, L., van den Brandt, J., Karabinskaya, A., Labi, V., Villunger, A., Kretzschmar, B., Huppke, P., Simons, M., Tuckermann, J.P., Fluegel, A., Luehder, F., Reichardt, H.M., Reichardt, H.M. Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses. Acta Neuropathologica 2014; 127(--):713-729. >>> Plerixafor; SC; Mice; 1002; Controls received sham operation; animal info (C57BL6); neurodegenerative (multiple sclerosis); immunology; Plerixafor is a CXCR4 antagonist;.

14210 Goettle, P., Sabo, J.K., Heinen, A., Venables, G., Torres, K., Tzekova, N., Parras, C.M., Kremer, D., Hartung, H.P., Cate, H.S., Kuery, P., Kuery, P. Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling. Journal of Neuroscience 2015; 35(--):906-919. >>> Bone morphogenic protein 4 recombinant human; noggin, mouse; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (female, C57BL6, adult); ALZET brain infusion kit 3 used; neurodegenerative (multiple sclerosis);.

14753 Gruber, R.C., Ray, A.K., Johndrow, C.T., Guzik, H., Burek, D., de Frutos, P.G., Shafit-Zagardo, B., Shafit-Zagardo, B. Targeted GAS6 Delivery to the CNS Protects Axons from Damage during Experimental Autoimmune Encephalomyelitis. Journal of Neuroscience 2014; 34(--):16320-16335. >>> GAS6, g-carboxylated full-length human; CSF, artificial; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J or Gas6 -/0, 8-12 weeks old); ALZET brain infusion kit 3 used; neurodegenerative (multiple sclerosis); cyanoacrylate adhesive; Cannula placement verified via India ink dye; used dental cement; incision closed with Vetbond; pumps primed in sterile PBS at 37C; delayed delivery; catheter filled with aCSF"...mice began to receive the contents of each pump 2–3 d after attachment."pg 16321;.

14729 El-Etr, M., Rame, M., Boucher, C., Ghoumari, A.M., Kumar, N., Liere, P., Pianos, A., Schumacher, M., Sitruk-Ware, R., El-Etr, M. Progesterone and Nestorone Promote Myelin Regeneration in Chronic Demyelinating Lesions of Corpus Callosum and Cerebral Cortex. Glia 2015; 63(--):104-117. >>> Nestorone; Molecusol; SC; Mice; 2004; Animal info (female, C57BL6, 8 weeks old, ovariectomized); functionality of mp verified by plasma levels; 40% molecusol used; neurodegenerative (multiple sclerosis);.

13992 Wollberg, A.R., Ericsson-Dahlstrand, A., Jureus, A., Ekerot, P., Simon, S., Nilsson, M., Wiklund, S.J., Berg, A.L., Ferm, M., Sunnemark, D., Johansson, R. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014; 111(-14-):5409-5414. >>> AZD8797; Cyclodextrin, B- hydroxypropyl; SC; Rat; Controls received mp w/ vehicle; animal info ( female, Dark Agouti); functionality of mp verified by plasma samples; pumps replaced every 2 weeks; 35% cyclodextrin used; dose-response (pg 5411); neurodegenerative (multiple sclerosis);"Because of less optimal pharmacokinetic (PK) properties of AZD8797 in the rat for oral treatment, we chose continuous treatment via s.c. osmotic mini pumps as the route of administration to enable sufficient exposure and to avoid periods without exposure between dosings"pg 5410;"from our extensive experience with conducting pharmacological treatment studies in EAE, we have learned that the model is very sensitive to stress. Repeated dosings for long periods stresses the animals. Implanted minipumps that are only changed once during the study period cause much less stress to the animals and reduce the risk of study biases"pg 5410; AZD8797 is a CX3CR1 inhibitor;.

13882 Niimi, N., Kohyama, K., Matsumoto, Y. Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases. NEUROPATHOLOGY 2013; 33(-6-):612-620. >>> RNA, small interfering; IP; Rat; 2002; 2004; Animal info (Lewis, 8-12 weeks old, experimental autoimmune encephalomyelitis); neurodegenerative (multiple sclerosis); gene therapy; immunology;.

13871 Mori, F., Nistico, R., Mandolesi, G., Piccinin, S., Mango, D., Kusayanagi, H., Berretta, N., Bergami, A., Gentile, A., Musella, A., Nicoletti, C.G., Nicoletti, F., Buttari, F., Mercuri, N.B., Martino, G., Furlan, R., Centonze, D. Interleukin-1beta Promotes Long-Term Potentiation in Patients with Multiple Sclerosis. NEUROMOLECULAR MEDICINE 2014; 16(-1-):38-51. >>> Interleukin-1, receptor antagonist; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (female, C57BL6, 6-8 weeks old); ALZET brain infusion kit 3 used; neurodegenerative (multiple sclerosis); immunology;.

13651 Mohammad, M.G., Tsai, V.W.W., Ruitenberg, M.J., Hassanpour, M., Li, H., Hart, P.H., Breit, S.N., Sawchenko, P.E., Brownl, D.A. Immune cell trafficking from the brain maintains CNS immune tolerance. Journal of Clinical Investigation 2014; 124(-3-):1228-1241. >>> Fingolimod; DMSO; CSF/CNS (forebrain; hippocampus); SC (cervical lymph nodes); Mice (transgenic); Controls received mp w/ vehicle; animal info (female, C57BL6, 6-12 weeks old; 2D2 transgenic); ALZET brain infusion kit 3 used; 50% DMSO used; neurodegenerative (multiple sclerosis); tissue perfusion (forebrain, hippocampus, cervical lymph nodes); immunology; Cannula placement verified via Nissl staining;.

13649 Mandolesi, G., Musella, A., Gentile, A., Grasselli, G., Haji, N., Sepman, H., Fresegna, D., Bullitta, S., De Vito, F., Musumeci, G., Di Sanza, C., Strata, P., Centonze, D. Interleukin-1beta Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis. Journal of Neuroscience 2013; 33(-29-):12105-12121. >>> Interleukin-1, receptor antagonist; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (Female, C57BL6, 7-8 weeks old); ALZET brain infusion kit 3 used; neurodegenerative (multiple sclerosis);.

13328 Takahashi, C., Muramatsu, R., Fujimura, H., Mochizuki, H., Yamashita, T. Prostacyclin promotes oligodendrocyte precurso recruitment and remyelination after spinal cord demyelination. Cell Death&Disease 2013; 4(--):1-9. >>> Iloprost; CAY10441; Saline; CSF/CNS; Mice; 1002; 1007D; Animal info. (female); neurodegenerative (MS, multiple sclerosis).

9443 Nizri, E., Irony-Tur-Sinai, M., Faranesh, N., Lavon, I., Lavi, E., Weinstock, M., Brenner, T. Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. Journal of Neuroimmunology 2008; 203(-1-):12-22. >>> Rivastigmine; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; comparison of SC injections vs. mp; half-life (p. 13) 4 hours; enzyme inhibitor (acetylcholinesterase); animal info (female, C57BL/6, 8 wks old, EAE); neurodegenerative (multiple sclerosis); behavioral testing (Morris water maze);"Delivery of rivastigmine by mini-osmotic pumps to ensure more uniform + continuous AChE inhibition was more effective than single daily doses and reduced disease severity and cummulative score by 73% and 72%, respectively."(p.17).

9092 Wang, J.Y., Takeuchi, H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T., Suzumura, A. Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-10-):3915-3920. >>> Midkine; PBS; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (Mk -/-); neurodegenerative (multiple sclerosis); midkine (MK) is a heparin binding growth factor.

8880 Matute, C., Torre, I., Perez-Cerda, F., Perez-Samartin, A., Alberdi, E., Etxebarria, E., Arranz, A.M., Ravid, R., Rodriguez-Antigueedad, A., Saanchez-Goomez, M.V., Domercq, M. P2X7 receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. Journal of Neuroscience 2007; 27(-35-):9525-9533. >>> Adenosine triphosphate-gamma-S; adenosine triphosphate, 2', 3'-O-(benzoyl-4-benzoyl)-; adenosine triphosphate, oxidized; dye, brilliant blue G; Saline; PBS, sterile; CSF/CNS (optic nerve); Rabbit; 1003D; Controls received mp w/ vehicle; neurodegenerative (multiple sclerosis).

8858 Fitzgerald, D.C., Ciric, B., Touil, T., Harle, H., Grammatikopolou, J., Das Sarma, J., Gran, B., Zhang, G.X., Rostami, A. Suppressive effect of IL-27 on encephalitogenic Th17 cellsAnd the effector phase of experimental autoimmune encephalomyelitis1. Journal of Immunology 2007; 179(-5-):3268-3275. >>> Interleukin-27, recomb. mouse; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (female, C57BL/6, 8-12 wks old); neurodegenerative (multiple sclerosis);"initially we tested i.p. injection of recombinant carrier-free IL-27 however, these experiments did not provide reproducible findings. To achieve continual, consistent delivery of cytokine throughout the treatment period, we implanted osmotic minipumps."(p. 3273); immunology.

8710 Bhasin, M., Wu, M.Z., Tsirka, S.E. Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis. BMC IMMUNOLOGY 2007; 8(--):U1-U16. >>> Tuftsin; macrophage inhibitory factor; SC; Mice; 2002; Controls received mp w/ PBS; pumps replaced after 14 days; enzyme inhibitor (ACE); immunology; peptides; animal info (female, tPA -/- or wt, 6-10 weeks old); neurodegenerative (Multiple Sclerosis).

8495 Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A., Wenk, G.L. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience 2006; 142(-4-):1303-1315. >>> Endotoxin, LPS; memantine; CSF, artificial; SC; CSF/CNS (fourth ventricle); Rat; 2004; 2ML4; Controls received mp w/ vehicle; no stress (see pg. 1308); multiple pumps per animal (2); animal info (male, F-344, 3 months old); neurodegenerative (Alzheimer's disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, etc.).

8070 Liu, Y.R., Liu, J., Tetzlaff, W., Paty, D.W., Cynader, M.S. Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis. Free Radical Biology and Medicine 2006; 40(-6-):960-967. >>> CSF, artificial; CSF, artificial; gentamicin; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; Immunology; animal info (male, Lewis, 200g., EAE (experimental autoimmune encephalomyelitis)); freshly prepared antioxidant enzymes were delivered intrathecally once daily through the PE tubing via Hamilton syringe on days 13-17, mp then reconnected to keep tube clear; multiple sclerosis model; pump used to maintain catheter patency.

7697 Meehan, T.F., Vanhooke, J., Prahl, J., DeLuca, H.F. Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice. Archives of Biochemistry and Biophysics 2005; 442(-2-):214-221. >>> Parathyroid hormone, human 1-34; Sodium chloride; HCl; serum, mouse heat inactivated; SC; Mice; 1002; Controls received mp w/ vehicle; functionality of mp verified by residual volume; peptides; neurodegenative (multiple sclerosis); animal info (1a-hydroxylase knockout, male, female).

6551 Tsutsui, S., Schnermann, J., Noorbakhsh, F., Henry, S., Yong, V.W., Winston, B.W., Warren, K., Power, C. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. Journal of Neuroscience 2004; 24(-6-):1521-1529. >>> Caffeine; ADAC; Saline; DMSO; SC; Mice; 1% DMSO used; pump model not listed; ADAC is an A1AR agonist adenosine amine congener; neurodegenerative (Multiple Sclerosis).

6439 Akassoglou, K., Adams, R.A., Bauer, J., Mercado, P., Tseveleki, V., Lassmann, H., Probert, L., Strickland, S. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-17-):6698-6703. >>> Ancrod; SC; Mice (transgenic); 2002; Neurodegenerative (Multiple Sclerosis); ancrod is snake venom.

5455 Proescholdt, M.A., Jacobson, S., Tresser, N., Oldfield, E.H., Merrill, M.J. Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats. Journal of Neuropathology and Experimental Neurology 2002; 61(-10-):914-925. >>> Vascular endothelial growth factor; PBS; albumin, rat serum; CSF/CNS (caudate putamen); Rat; 2002; Controls received mp w/ vehicle; peptides; 3-day recovery period by vehicle infusion; mouse recomb. VEGF used; neurodegenerative (Multiple Sclerosis).

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7. Niemann-Pick Type C Disease

14292 Marschalek, N., Albert, F., Meske, V., Ohm, T.G., Ohm, T.G. The natural history of cerebellar degeneration of Niemann-Pick C mice monitored in vitro. Neuropathology and Applied Neurobiology 2014; 40(--):933-945. >>> Cyclodextrin, 2-hydroxypropyl-B-; CSF/CNS; Mice; Animal info (NPC); pumps mentioned in introduction.

14591 Trovo, L., Stroobants, S., D'Hooge, R., Ledesma, M.D., Dotti, C.G., Trovo, L. Improvement of biochemical and behavioral defects in the Niemann-Pick type A mouse by intraventricular infusion of MARCKS. NEUROBIOLOGY OF DISEASE 2015; 73(--):319-326. >>> MARCKS peptide; Saline, sterile; CSF/CNS; Mice; 1004; Control animals received mp w/ vehicle; animal info (ASMko, 4 mo old); peptides; ALZET brain infusion kit 3 used; cyanoacrylate used; behavioral testing (accelerating rotarod); MARCKS is a protein required for PI(4,5)P2 membrane clustering and hydrolysis.

12272 Cabeza, C., Figueroa, A., Lazo, O.M., Galleguillos, C., Pissani, C., Klein, A., Gonzalez-Billault, C., Inestrosa, N.C., Alvarez, A.R., Zanlungo, S., Bronfman, F.C. Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease. Molecular Neurodegeneration 2012; 7(-;-):U1-U18. >>> Nerve growth factor; CSF, artificial; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (BALB/c, NPC/1 -/-); aCSF recipe; brain infusion kit used.

9503 Zhang, M., Hallows, J.L., Wang, X.Z., Bu, B.T., Wang, W., Vincent, I. Mitogen-activated protein kinase activity may not be necessary for the neuropathology of Niemann-Pick type C mice. Journal of Neurochemistry 2008; 107(-3-):814-822. >>> PD-98059; DMSO; saline; dye, Evan's blue; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; functionality of mp verified by dye infusion; dose-response (fig. 1); enzyme inhibitor (MAPK/ERK 1); brain tissue distribution; animal info (female, BALB/c, Nctr-Npc, 5 wks old); 50% DMSO used; behavioral testing (limb motor activity/coat hanger test).

7124 Zhang, M., Li, J., Chakrabarty, P., Bu, B.T., Vincent, I. Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick type C mice. American Journal of Pathology 2004; 165(-3-):843-853. >>> Roscovitine; olomoucine; iso-olomoucine; DMSO; CSF/CNS; Mice; 1002; Pumps replaced every 2 weeks for 4 week infusions; enzyme inhibitor (CDK); neurodegenerative (Alzheimer's disease, Amyotrophic Lateral Sclerosis, Niemann-Pick Type C disease); lynch coil used to accomodate 75% DMSO.

6020 Camargo, F., Erickson, R.P., Garver, W.S., Hossain, G.S., Carbone, P.N., Heidenreich, R.A., Blanchard, J. Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease. Life Sci 2001; 70(-2-):131-142. >>> Cyclodextrin, 2-hydroxypropyl-ß-; Saline, sterile; CSF/CNS; Mice (knockout); 2004; stress/adverse reaction: (see pg.139) mice were active&broke the cemented cannulae away from the skull; ALZET brain infusion kit 2 used (per Dr. Erickson); 2-Hydroxypropyl-ß-cyclodextrin is (HPBCD); methylene blue dye infused (probably not by pump) after cyclodextrin infusion to confirm the intraventricular location; delivery route somewhat confusing - paper refers to the route alternately as intrathecal and intraventricular; neurodegenerative (Niemann-Pick Type C disease).

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8. Parkinson's Disease

16214 Morin, N., Morissette, M., Gregoire, L., Rajput, A., Rajput, A. H., Di Paolo, T. Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications. Neuropharmacology 2015; 99(--):356-68. >>> MPTP; Saline; SC; Monkey (macaque); Controls received no treatment; animal info (drug naive female ovariectomized monkeys (Macaca fascicularis) (aged 4.7e7.7 y; weight: 2.7e4.2 kg;); functionality of mp verified by observation for disability signs; neurodegenerative (Parkinson’s Disease); behavioral testing (disability testing); MPTP - neurotoxin; Dose (0.5 mg/24 h);.

16148 Padel, T., Ozen, I., Boix, J., Barbariga, M., Gaceb, A., Roth, M., Paul, G. Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease. Neurobiol Dis 2016; 94(--):95-105. >>> Platelet-derived growth factor-BB; CSF, artificial; mouse serum albumin; gentamicin; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (male, rgs5 GFP/+ KO/KI); ALZET brain infusion kit used; neurodegenerative (Parkinson’s disease); cyanoacrylate adhesive; pumps removed after 14 days; catheter tubing sealed with glue after pump removal; Brain coordinates; Dose (36 ng/day PDGF-BB);.

16089 Zhuang, X., Chen, Y., Zhuang, X., Chen, T., Xing, T., Wang, W., Yang, X. Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway. Front Neurol 2016; 7(--):104. >>> Interleukin-1, receptor antagonist; SC144; etanercept; muscimol; CSF, artificial; CSF/CNS (midbrain periaqueductal gray); Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 150-200g); ALZET brain infusion kit used; neurodegenerative (Parkinson’s disease); behavioral testing (paw withdrawal latency; von Frey filaments); SC144 is an gp130 antagonist; etanercept is a TNF-a receptor antagonist; muscimol is a GABAa receptor agonist; Brain coordinates (7.6 mm posterior to the bregma 0.65 mm lateral to the midline, and 4.2 mm ventral to thebrain surface.);.

16046 Tong, Q., Wu, L., Gao, Q., Ou, Z., Zhu, D., Zhang, Y. PPARbeta/delta Agonist Provides Neuroprotection by Suppression of IRE1alpha-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease. Mol Neurobiol 2016; 53(-6-):3822-31. >>> GW501516; DMSO; saline; CSF/CNS; Rat; 2006; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-220g); animal info (male, Sprague Dawley, 200-220g); 30% DMSO used; neurodegenerative (Parkinson’s); behavioral testing (open field test; catalepsy test); “GW501516 does not readily cross the blood–brain barrier, so GW501516 or vehicle was administrated intracerebroventricularly.” pg 3823; pumps primed in 37C saline overnight; Brain coordinates (0.8 mm posterior to the bregma, 1.5 mmlateral to the midsagittal suture, and 4.0 mm ventral to the skull);.

15918 Murakami, S., Miyazaki, I., Miyoshi, K., Asanuma, M. Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson's Disease in Mice. Neurochem Res 2015; 40(-6-):1165-78. >>> Rotenone; DMSO; PEG; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 20-25g, 9 weeks old); pumps replaced every 3 weeks; 50% DMSO used; 50% PEG used; neurodegenerative (Parkinson's disease); behavioral testing (locomotor activity); Dose (50 mg/kg/day);.

15785 Aurelie Ledreux, HeatherA.Boger, VanessaK.Hinson, KelseyCantwell, Ann-Charlotte Granholm. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson'sdisease. Brain Res 2016; 1631(-34-45-):. >>> Rasagiline; aminoindan; Saline, sterile; SC; Rat; Controls received mp w/ vehicle; animal info (male, Fisher 344, 175-200g); neurodegenerative (Parkinson's disease); behavioral testing (novel object recognition; spontaneous locomotion); Dose (3 mg/kg/day);.

15236 Sonsalla, P.K., Coleman, C., Wong, L.Y., Harris, S.L., Richardson, J.R., Gadad, B.S., Li, W.H., German, D.C. The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism. EXPERIMENTAL NEUROLOGY 2013; 250(-;-):376-383. >>> MPP+iodide; Saline, sterile; CSF/CNS; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 300g); neurodegenerative (Parkinson's disease); post op. care (rimadyl 5 mg/kg SC, ampacillin 100 mg/kg IM);.

15203 Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G.F., Franco, R., Lanciego, J.L., Baqi, Y., Mueller, C.E., Pinna, A., Blandini, F., Armentero, M.T., Armentero, M.T. Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease351. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2014; 73(--):414-424. >>> Rimonabant; MSX-3; DMSO; PEG; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-225g); 50% DMSO used; 50% PEG used; dose-response (pg 417); neurodegenerative (Parkinson disease);.

15132 Wang, Q.S., Qian, L., Chen, S.H., Chu, C.H., Wilson, B., Oyarzabal, E., Ali, S., Robinson, B., Rao, D., Hong, J.S., Wang, Q.S. Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models. BRAIN 2015; 138(--):1247-1262. >>> Diphenyleneiodonium; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (C57BL6J or B6.C3-Tg); neurodegenerative (Parkinson's disease); Diphenyleneiodonium aka DPI; exzyme inhibitor (nicotinamide adenine dinucleotide phosphate oxidase).

15091 Stayte, S., Rentsch, P., Li, K.M., Vissel, B., Vissel, B. Activin A Protects Midbrain Neurons in the 6-Hydroxydopamine Mouse Model of Parkinson's Disease. PLoS One 2015; 10(--):U1330-U1344. >>> Activin A, recombinant; PBS; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6, 12 weeks old); neurodegenerative (Parkinson's disease);“No effect of direct physical damage caused by the infusion was found” pg 5; used Plastics one cannula; pumps removed 1 week later and cannula tubing sealed with heat;.

14800 Razgado-Hernandez, L.F., Espadas-Alvarez, A.J., Reyna-Velazquez, P., Sierra-Sanchez, A., naya-Martinez, V., Jimenez-Estrada, I., Bannon, M.J., Martinez-Fong, D., ceves-Ruiz, J., ceves-Ruiz, J. The Transfection of BDNF to Dopamine Neurons Potentiates the Effect of Dopamine D3 Receptor Agonist Recovering the Striatal Innervation, Dendritic Spines and Motor Behavior in an Aged Rat Model of Parkinson's Disease. PLoS One 2015; 10(--):U852-U876. >>> 7-OH-DPAT; IP; Rat; 2006; Animal info (male, Wistar, 17 months old, 400-500g); pumps replaced every 1.5 months; neurodegenerative (Parkinson's disease); behavioral testing (gait analysis, rotarod performance, open field); 7-OH-DPAT aka 7-hydroxy-N,N-di-n-propy1-2-aminotetralin;.

14769 Su, X.M., Chu, Y.P., Kordower, J.H., Li, B., Cao, H., Huang, L., Nishida, M., Song, L., Wang, D.F., Federoff, H.J., Federoff, H.J. PGC-1alpha Promoter Methylation in Parkinson's Disease. PLoS One 2015; 10(--):U253-U276. >>> Palmitate; Saline; CSF/CNS; Mice; 1002; Animal info (DMSYN, male, 6 mo old, 28-32 g); neurodegenerative (Parkinson's disease).

14308 Morin, N., Morissette, M., Gregoire, L., Di Paolo, T., Di Paolo, T. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2015; 56(--):27-38. >>> MPTP; Saline; SC; Monkey (macaque); Controls received mp w/ vehicle; animal info (female, Macaca fascicularis, ovariectomized, 4.7-7.7 years old, 2.7-4.2kg); long-term study; neurodegenerative (Parkinson's disease);.

14206 Fu, S.P., Wang, J.F., Xue, W.J., Liu, H.M., Liu, B.R., Zeng, Y.L., Li, S.N., Huang, B.X., Lv, Q.K., Wang, W., Liu, J.X., Wang, W. Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms. Journal of Neuroinflammation 2015; 12(--):U16-U29. >>> Hydroxybutryic acid, B-; PBS; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 250-290g); neurodegenerative (Parkinson's disease); behavioral testing (rotational behavior); immunology;.

14203 Fremont, R., Calderon, D.P., Maleki, S., Khodakhah, K., Khodakhah, K. Abnormal High-Frequency Burst Firing of Cerebellar Neurons in Rapid-Onset Dystonia-Parkinsonism. Journal of Neuroscience 2014; 34(--):11723-11732. >>> Ouabain; Methylene blue dye; CSF/CNS (cerebellum); Mice; 1007D; Controls received mp w/ saline; animal info (male, C57BL6, 8-10 weeks old); 0.01% methylene blue used; neurodegenerative (Parkinson's disease); post op. care (flunixin 2.5 mg/kg SC); used Plastics One cannula;.

14715 Dugan, L.L., Tian, L.L., Quick, K.L., Hardt, J.I., Karimi, M., Brown, C., Loftin, S., Flores, H., Moerlein, S.M., Polich, J., Tabbal, S.D., Mink, J.W., Perlmutter, J.S., Perlmutter, J.S. Carboxyfullerene Neuroprotection Postinjury in Parkinsonian Nonhuman Primates. Annals of Neurology 2014; 76(--):393-402. >>> C3; SC; IP; Monkey (macaque); 2ML4; Controls received mp w/ placebo; animal info (Macaca facicularis); Multiple pumps per animal (2); neurodegenerative (Parkinson's disease); behavioral testing (locomotor activity); stability verified by (testing at 37C, C3 is stable for>40 days); Carboxyfullerine aka C3;.

15694 Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G.F., Franco, R., Lanciego, J.L., Baqi, Y., Mueller, C.E., Pinna, A., Blandini, F., Armentero, M.T., Armentero, M.T. Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease. Journal of Neuropathology and Experimental Neurology 2014; 73(--):414-424. >>> Rimonabant; MSX-3;; DMSO; PEG; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-225g); 50% DMSO used; 50% PEG used; Multiple pumps per animal (2); neurodegenerative (parkinson's disease);.

13927 Sehgal, A., Chen, Q.M., Gibbings, D., Sah, D.W.Y., Bumcrot, D. Tissue-specific gene silencing monitored in circulating RNA. RNA-A PUBLICATION OF THE RNA SOCIETY 2014; 20(-2-):143-149. >>> RNA, small interfering; PBS; CSF/CNS (striatum); Rat; Animal info (male, Sprague Dawley); neurodegenerative (Parkinson's disease); tissue perfusion (striatum); gene therapy; used Plastics One 30g cannula; primed overnight in 37C saline;.

13922 Savolainen, M.H., Richie, C.T., Harvey, B.K., Maennistoe, P.T., Maguire-Zeiss, K.A., Myoehaenen, T.T., Myoehaenen, T.T. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. NEUROBIOLOGY OF DISEASE 2014; 68(--):1-15. >>> KYP-2047; DMSO; saline; IP; Mice (transgenic); Controls received mp w/ vehicle; animal info (Snca tm(A30P) or WT, 12-13 months old); functionality of mp verified by decrease in PREP activity; 50% DMSO used; neurodegenerative (Parkinson's disease; Lewy body dementia); post op. care (buprenorphine); stability verified by (stability experiment one month); pumps primed overnight in 37C saline; KYP-2047 is a enzyme inhibitor (PREP);.

13878 Naidoo, J., De Jesus-Cortes, H., Huntington, P., Estill, S., Morlock, L.K., Starwalt, R., Mangano, T.J., Williams, N.S., Pieper, A.A., Ready, J.M., Pieper, A.A. Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6- methoxypyridin-2-amine [(-)-P7C3-S243], with Improved Druglike Properties. Journal of Medicinal Chemistry 2014; 57(--):3746-3754. >>> P7C3-S243; CSF/CNS; Mice; 1007D; Animal info (C57BL6, 12 weeks old); brain tissue distribution; P7C3-S243 is a aminopropyl carbazole; neurodegenerative (Parkinson's disease);.

13872 Morin, N., Jourdain, V.A., Morissette, M., Gregoire, L., Di Paolo, T. Long-term treatment with L-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys. Neuropharmacology 2014; 79(-;-):688-706. >>> MPTP; Saline; SC; Monkey (Macaca fascicularis); Controls received mp w/ vehicle; animal info (female, OVX, 4.7-7.7 years old, 2.7-4.2 kg); neurodegenerative (Parkinson's); long-term study; MPTP aka 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; monkeys treated until parkinsonian features were achieved;.

13768 Ferreira, N., Pereira-Henriques, A., Attar, A., Klaerner, F.G., Schrader, T., Bitan, G., Gales, L., Saraiva, M.J., Almeida, M.R., Almeida, M.R. Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics 2014; 11(--):450-461. >>> CLR01; SC; Mice; 1004; Animal info (4 months old); neurodegenerative (Alzheimer's disease; parkinson's disease); no stress (see pg.453); CLR01 inhibits self-assembly and toxicity of amyloidogenic proteins.

13731 Carmo, M.R.S., Menezes, A.P.F., Nunes, A.C.L., Pliassova, A., Rolo, A.P., Palmeira, C.M., Cunha, R.A., Canas, P.M., Andrade, G.M., Cunha, R.A. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology 2014; 81(--):142-152. >>> A438079; Saline; CSF/CNS; Rat; 1002; Controls received mp w/ vehicle; animal info (male, Wistar, adult, 200-250g); ALZET brain infusion kit 2 used; neurodegenerative (parkinson's disease); behavioral testing (rotational behavior; open field test; passive avoidance; Morris Water Maze); A438079 is a selective P2X7R antagonist.

13683 Bordia, T., McGregor, M., Papke, R.L., Decker, M.W., McIntosh, J.M., Quik, M., Quik, M. The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental Neurology 2015; 263(--):277-284. >>> Nicotine; ABT-107; DMXB; Rat; 2006; Control animals received mp w/ vehicle; animal info (male, Sprague Dawley, 120-140 g); neurodegenerative (Parkinson's disease).

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What researchers are saying ...

“We developed the optic nerve/osmotic pump infusion technique to deliver soluble ligands, agonists, or antagonists directly into the optic nerve.The advantages of this technique are that the infused drugs remain largely confined within the experimental nerve, reducing the impact of potential systemic side effects; mere placement of the catheter and subsequent infusion of the vehicle solution do not promote lesion-like changes within the optic nerve…” Rodgers et al., GLIA 41:180-190; 2003.