References on the Administration of Nicotine Using ALZET® Osmotic Pumps

16319 Yang, J., Liu, A. Y., Tang, B., Luo, D., Lai, Y. J., Zhu, B. L., Wang, X. F., Yan, Z., Chen, G. J. Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons. BMC Genomics 2017; 18(-1-):194. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male mice 20 g, 5–7 weeks old); Dose (48 mg/kg/d);.

16280 Younes-Rapozo, V., Moura, E. G., Manhaes, A. C., Pinheiro, C. R., Carvalho, J. C., Barradas, P. C., de Oliveira, E., Lisboa, P. C. Neonatal Nicotine Exposure Leads to Hypothalamic Gliosis in Adult Overweight Rats. J Neuroendocrinol 2015; 27(-12-):887-98. >>> Nicotine; Saline; SC; Rat (pregnant); 2ML2; Controls received mp w/ vehicle; animal info (Wistar rats, pregnant); functionality of mp verified by plasma levels; Pumps primed for 24 hrs; Resultant plasma level (cotinine 25 ng/ml); Dose (6 mg/kg/d);.

16271 Vivekanandarajah, A., Waters, K. A., Machaalani, R. Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem. Int J Dev Neurosci 2015; 47(-Pt B-):183-91. >>> Nicotine Hydrogen Tartrate; water; IP; Pig (mini); 2ML2; Controls received mp w/ vehicle; animal info (piglets); functionality of mp verified by blood and urine samples; toxicology; Dose (2 mg/kg/d); Resultant plasma level (20.3±2.5 ng/mL);.

16249 Slotkin, T. A., Skavicus, S., Seidler, F. J. Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos. Toxicology 2015; 338(--):8-16. >>> Nicotine Bitartrate; Water, bacteriostatic; SC; Rat (pregnant); 2ML2; Controls received mp w/ vehicle; animal info (pregnant Sprague-Dawley rats, 211-217g); animal info (pregnant Sprague-Dawley rats, 211-217g); dependence; Wound clips used; Dose (3 mg/kg/day);.

16246 Shih, P. Y., McIntosh, J. M., Drenan, R. M. Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula. Mol Pharmacol 2015; 88(-6-):1035-44. >>> Nicotine hydrogen-tartrate salt; Saline; SC; mice; 2004; Controls received mp w/ vehicle; animal info (Adult (2–3 months old) mice; C57BL/6 wild-type); functionality of mp verified by plasma levels; functionality of mp verified by plasma levels; dependence; Dose (1 mg/kg/hr); Resultant plasma level (0.3 uM; 40 ng/ml);.

16234 Renaud, S. M., Pickens, L. R., Fountain, S. B. Paradoxical effects of injection stress and nicotine exposure experienced during adolescence on learning in a serial multiple choice (SMC) task in adult female rats. Neurotoxicol Teratol 2015; 48(--):40-8. >>> Nicotine bitartrate; Water, bacteriostatic; SC; rat; 2004; Controls received mp w/ vehicle; animal info: female Long Evans rats; functionality of mp verified by behavioral test; dose-response (pg 43-44); neurodegenerative (learning impairments); behavioral testing (serial multiple choice); effects of adolescent nicotine exposure on learning in adulthood; anesthetized under isoflurane; Dose: 0.033 mg/h.

16215 Muelken, P., Schmidt, C. E., Shelley, D., Tally, L., Harris, A. C. A Two-Day Continuous Nicotine Infusion Is Sufficient to Demonstrate Nicotine Withdrawal in Rats as Measured Using Intracranial Self-Stimulation. PLoS One 2015; 10(-12-):e0144553. >>> Nicotine bitartrate; Saline, physiological; SC; rat; 2ML2; Controls received mp w/ vehicle; animal info (Male Wistar rats, 275–300 g); functionality of mp verified by elevations in intracranial self-stimulation; dose-response (pg 8, 9); post op. care (buprenorphine, ceftriaxone); behavioral testing (intracranial self-stimulation pg 4); Dependence, nicotine; “elevations in ICSS thresholds beginning on the second day ofinfusion” (Pg. 1); primed in saline for 1 hour prior to implantation; Dose (3.2 mg/kg/day);.

16195 Lee, B. G., Anastasia, A., Hempstead, B. L., Lee, F. S., Blendy, J. A. Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine Tob Res 2015; 17(-12-):1428-35. >>> Nicotine hydrogen tartrate salt; Saline; SC; mice; 2002; Controls received mp w/ vehicle; animal info: Mice (23–38 g; 2–4 months old); functionality of mp verified by behavior; behavioral testing (withdrawal measurements); Dependence nicotine; Dose: 18 mg /kg/day.

16180 Simmons, S. J., Gentile, T. A., Mo, L., Tran, F. H., Ma, S., Muschamp, J. W. Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats. Behav Brain Res 2016; 314(--):226-33. >>> Nicotine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult); behavioral testing (open field); dependence; used staples (9mm); Dose (3.16 mg/kg/day free base);.

16137 Hoegberg, B. G., Lomazzo, E., Lee, N. H., Perry, D. C. Regulation of alpha4beta2alpha5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. Neuropharmacology 2015; 99(--):347-55. >>> Nicotine hydrogen tartrate; Saline; SC; SC; 2002; Controls received mp w/ vehicle; animal info: Sprague Dawley rats; dose-response (pg 350); post op. care (buprenorphine); dependence; Dose: 17 mg/kg/day.

16112 de la Pena, J. B., Ahsan, H. M., Tampus, R., Botanas, C. J., dela Pena, I. J., Kim, H. J., Sohn, A., dela Pena, I., Shin, C. Y., Ryu, J. H., Cheong, J. H. Cigarette smoke exposure during adolescence enhances sensitivity to the rewarding effects of nicotine in adulthood, even after a long period of abstinence. Neuropharmacology 2015; 99(--):9-14. >>> Nicotine; SC; rat; 2ML2; Controls received sham pumps; animal info: Male Sprague Dawley; dose-response (pg 12); behavioral testing (conditioned place preferences (CPP) and self-administration tests); dependence, nicotine; Dose: 3.2 mg/kg/day.

16104 Cerpa, V. J., Aylwin Mde, L., Beltran-Castillo, S., Bravo, E. U., Llona, I. R., Richerson, G. B., Eugenin, J. L. The Alteration of Neonatal Raphe Neurons by Prenatal-Perinatal Nicotine. Meaning for Sudden Infant Death Syndrome. Am J Respir Cell Mol Biol 2015; 53(-4-):489-99. >>> Nicotine bitartrate; saline; SC; Mice (pregnant); 2004; Controls received mp w/ vehicle; animal info 5-7 days pregnant adult mice; dependence, nicotine; Pump delivery mimics the tendency of smokers to maintain a constant blood level of nicotine throughout the day; Dose: (60 mg kg-1 day-1).

16084 Zhao, L., Zhuang, J., Xu, F. Bronchopulmonary C-fibers'IL1RI contributes to the prolonged apneic response to intra-atrial injection of capsaicin by prenatal nicotinic exposure in rat pups. Toxicol Appl Pharmacol 2016; 303(--):58-64. >>> Nicotine; methyllycaconitine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced every 28 days; Multiple pumps per animal (2); long-term study; teratology; MLA is an a7nAChR antagonist; methyllycaconitine aka MLA; Dose (nicotine 6 mg/kg/day; MLA 3 mg/kg/day);.

16027 Hussmann, G. P., DeDominicis, K. E., Turner, J. R., Yasuda, R. P., Klehm, J., Forcelli, P. A., Xiao, Y., Richardson, J. R., Sahibzada, N., Wolfe, B. B., Lindstrom, J., Blendy, J. A., Kellar, K. J. Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem 2014; 129(-4-):721-31. >>> nicotine; sazetidine-A; varenicline; saline; SC; rat, mice; Controls received mp w/ saline vehicle; animal info (male adult Sprague-dawley rats, 8 weeks, 240 g; male 129SvJ;C57BL/6J F1 hybrid mice, 6 weeks, 25-30 g ); functionality of mp verified by protein binding in rat cortex ; pumps replaced after 2 weeks; 1 additional week of infusion for mice, 4 additional weeks of infusion for rats; post op. care (buprenorphine or ketoprofen injected for analgesia); behavioral testing (memory retention and attention in rats); Saz-A aka sazetidine-A; Rats Dose: 6 mg/kg/day nicotine, 4.7 mg/kg/day saz-A, 1.2 mg/kg/day vareniclineMice Dose: 18 mg/kg/day nicotine, 1.8 mg/kg/day saz-A, 1.8 mg/kg/day varenicline.

16026 Huang, L. T., Chou, H. C., Lin, C. M., Yeh, T. F., Chen, C. M. Maternal nicotine exposure exacerbates neonatal hyperoxia-induced lung fibrosis in rats. Neonatology 2014; 106(-2-):94-101. >>> nicotine tartrate; saline; SC; rats; 2ML2, 2ML4; Controls received mp w/ sterile saline vehicle; animal info (Sprague-dawley rats ages 7-21 days); functionality of mp verified by plasma levels; Western Blot analysis, histological exams ; Dose: 40 ug/ul nicotine tartrateà6mg/kg/day; Resultant plasma level (resembling moderate to heavy human smokers);.

16017 Gorini, C., Jameson, H., Woerman, A. L., Perry, D. C., Mendelowitz, D. Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways. J Appl Physiol (1985) 2013; 115(-4-):415-21. >>> nicotine; SC; rat; animal info: female, Sprague-Dawley, day 3 of gestation, pregnant; relationship between prenatal nicotine exposure and SIDS (sudden infant death syndrome); cardiovascular; dose: 6 mg/kg/day.

15983 Jackson, K. J., Jackson, A., Carroll, F. I., Damaj, M. I. Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice. Neuropharmacology 2015; 97(--):270-4. >>> Nicotine hydrogen tartrate salt; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, ICR, 8-10 weeks old); behavioral testing (elevated plus maze; hyperalgesia); dependence; Dose (24 mg/kg/day);.

15928 Pinheiro, C. R., Oliveira, E., Manhaes, A. C., Fraga, M. C., Claudio-Neto, S., Younes-Rapozo, V., Lotufo, B. M., Moura, E. G., Lisboa, P. C. Exposure to nicotine increases dopamine receptor content in the mesocorticolimbic pathway of rat dams and offspring during lactation. Pharmacol Biochem Behav 2015; 136(--):87-101. >>> Nicotine; Saline; SC; Rat (lactating); 2ML2; Controls received mp w/ vehicle; animal info (female, Wistar, PN2); Dose (6 mg/kg/day); Resultant plasma level (cotinine dams serum 239 ng/ml and in milk 226 ng/ml; cotinine levels in 15 days old pumps 20 ng/ml);.

15878 Slotkin, T. A., Skavicus, S., Card, J., Stadler, A., Levin, E. D., Seidler, F. J. Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. Toxicol Sci 2015; 147(-1-):178-89. >>> Nicotine; tobacco smoke extract; DMSO; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, non-pregnant, adult, Sprague Dawley); functionality of mp verified by plasma nicotine levels; dose-response (pg 181); teratology; Dose (Nicotine free base 0.2 or 2 mg/kg/day; TSE 0.18 mg/kg/day);.

15861 Zhao, L., Zhuang, J., Zang, N., Lin, Y., Lee, L. Y., Xu, F. Prenatal nicotinic exposure upregulates pulmonary C-fiber NK1R expression to prolong pulmonary C-fiber-mediated apneic response. Toxicol Appl Pharmacol 2016; 290(--):107-15. >>> Nicotine; mecamylamine; methyllycaconitine; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-300g); pumps replaced on GD7; Multiple pumps per animal (2); no stress (see pg. 110-111); teratology; Dose (Nicotine 6 mg/kg/day; mecamylamine 0.03 mg/kg/day; methyllycaconitine 3 mg/kg/day);.

15811 C.R. Pinheiro, E.G.Moura, A.C.Manhães, M.C. Fraga, S. Claudio-Neto, V. Younes-Rapozo, A.P. Santos-Silva, B.M. Lotufo, E. Oliveira, P.C. Lisboa  Physiol Behav 2015; 149(--):131-141. >>> Nicotine; Saline; SC; Rat (lactating); 2ML2; animal info (female, Wistar, PN2); behavioral testing (food preference);“Exposure to nicotine through subcutaneous osmotic minipump infusion was used to avoid the adverse effects of nicotine peaks” pg 132; Dose (6 mg/kg/day); Resultant plasma level (25 ng/ml,"similar to those found in typical smokers");.

15807 Vinay Parikh, Robert D. Cole,, Purav J. Patel,, Rachel L. Poole,, Thomas J. Gould  NEUROBIOLOGY OF LEARNING AND MEMORY 2016; 128(--):110-116. >>> Nicotine hydrogen tartrate; Saline, sterile; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-10 weeks old, 20-25g); functionality of mp verified by plasma cotinine levels; behavioral testing (visual discriminations, operant training); dependence; Dose (18 mg/kg/day free base resultedin 100-150 ng/ml plasma cotinine levels);.

15806 C C Paccola and S M Miraglia  REPRODUCTION 2016; 151(--):117-133. >>> Nicotine hydrogen tartrate salt; Water, bacteriostatic; SC; Rat (pregnant; lactating); 2ML4; Controls received mp w/ vehicle; animal info (GD1); pumps replaced after birth; no stress (see pg. 123); cyanoacrylate adhesive;“There were no cases of stillbirth, birth defects, or other signs of toxicity that could be attributed to nicotine. Behavioral changes in the rat dams that could be attributed to the stress caused by the osmotic minipump implant were also not evidenced. Body weights were obtained at every chosen age of killing and no differences were found when nicotine and control groups were compared, at any ageequivalent subgroup. The” pg 123; Dose (2 mg/kg/day);.

15789 Chun Li, Hong Sun, Denise M. Arrick, William G. Mayhan  J Appl. Physiol 2016; 120(--):328-333. >>> Nicotine; Saline; SC; Rat; Controls received mp w/ saline; animal info (male, Sprague Dawley, 250-300g); ischemia (cerebral);“The subcutaneous osmotic minipump releases nicotine at a constant rate, which resulted in stable plasma nicotine and cotinine levels that match the chronic smokers. The doses of nicotine used in the present study have been reported to result in stable plasma nicotine levels corresponding reasonably well with plasma levels in habitual light (0.5–1 pack/day) and moderate (2 packs/day) smokers” pg 331; traumatic brain injury; Dose (2 or 4 mg/kg/day);.

15768 Erivan Clementino Gualberto Jr., Letícia Helena Theodoro, Mariellén Longo, Vivian Cristina Noronha Novaes, Maria JoséHitomi Nagata, Edilson Ervolino, Valdir Gouveia Garcia  Lasers med sci 2016; 31(--):83-94. >>> Nicotine; Saline; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Wistar, 3 months old, 266+/-6.5g); pumps replaced after 40 days; Dose (6 mg/kg/day);.

15747 Kang Chen,, Sakura Nakauchi,, Hailing Su,, Saki Tanimoto,, Katumi Sumikawa  Neuropharmacology 2016; 101(--):57-67. >>> Nicotine; Saline; SC; Rat (lactating); 2ML2; animal info (female, Sprague Dawley, ); teratology; Dose (6 mg/kg/day);.

15227 Natividad, L.A., Torres, O.V., Friedman, T.C., O'Dell, L.E. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. BEHAVIOURAL BRAIN RESEARCH 2013; 257(-;-):275-285. >>> Nicotine; SC; Rat; 2ML2; Controls received sham surgery; animal info (male, Wistar); dependence; pumps removed after 14 days;.

15208 Cunningham, C.S., Moerke, M.J., McMahon, L.R., McMahon, L.R. The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys1734. BEHAVIOURAL PHARMACOLOGY 2014; 25(--):296-305. >>> Nicotine; Saline; SC; Monkey (Rhesus); 2ML4; Controls received mp w/ vehicle; animal info (Macaca mulatta, rhesus monkey, adult); pumps replaced every 28 days; behavioral testing (stimulus-shock termination);.

15198 Caine, S.B., Collins, G.T., Thomsen, M., Wright, C., Lanier, R.K., Mello, N.K. Nicotine-Like Behavioral Effects of the Minor Tobacco Alkaloids Nornicotine, Anabasine, and Anatabine in Male Rodents. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY 2014; 22(-1-):9-22. >>> Nicotine; SC; Mice; 1004; Animal info (male, Swiss Webster, 4-8 weeks old); dependence; pumps removed after 28 days;.

15167 Zanos, P., Georgiou, P., Metaxas, A., Kitchen, I., Winsky-Sommerer, R., Bailey, A., Bailey, A. Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration. NEUROSCIENCE LETTERS 2015; 600(--):33-37. >>> Nicotine; SC; Mice; 2002; Controls received mp w/ saline; animal info (male, C57BL/6J); dependence;.

15256 Wu, Y., Song, P., Zhang, W.C., Liu, J.H., Dai, X.Y., Liu, Z.Y., Lu, Q.L., Ouyang, C.H., Xie, Z.L., Zhao, Z.X., Zhuo, X.Z., Viollet, B., Foretz, M., Wu, J.L., Yuan, Z.Y., Zou, M.H., Zou, M.H. Activation of AMPKalpha2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. NATURE MEDICINE 2015; 21(--):373-+. >>> Nicotine; Saline; SC; Mice; rat; Controls received mp w/ vehicle; animal info (mice male, C57BL6J, 8 weeks old; rat male, Sprague Dawley, 10 weeks old); diabetes; long-term study;.

15124 Varani, A.P., Pedron, V.T., Machado, L.M., Antonelli, M.C., Bettler, B., Balerio, G.L.N., Balerio, G.L.N. Lack of GABA(B) receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal. NEUROPHARMACOLOGY 2015; 90(--):90-101. >>> Nicotine hydrogen tartrate salt; SC; Mice; 2001; Controls received mp w/ saline; animal info (male, BALB/C, 20-30g); behavioral testing (nicotine withdrawal; locomotor activity); dependence;.

15118 Torres, O.V., Pipkin, J.A., Ferree, P., Carcoba, L.M., O'Dell, L.E., O'Dell, L.E. Nicotine Withdrawal Increases Stress-Associated Genes in the Nucleus Accumbens of Female Rats in a Hormone-Dependent Manner. NICOTINE&TOBACCO RESEARCH 2015; 17(--):422-430. >>> Nicotine; SC; Rat; 2ML2; Controls received sham surgery; animal info (female, Wistar, PD60-62); behavioral testing (elevated plus maze, light-dark transfer procedures); dependence;.

15064 Powell, G.L., Levine, R.B., Frazier, A.M., Fregosi, R.F., Fregosi, R.F. Influence of developmental nicotine exposure on spike-timing precision and reliability in hypoglossal motoneurons. JOURNAL OF NEUROPHYSIOLOGY 2015; 113(--):1862-1872. >>> Nicotine bitartrate; SC; Rat (pregnant); Controls received mp w/ saline; animal info (Sprague Dawley, GD5); functionality of mp verified by plasma cotinine levels; teratology;.

15106 Nakauchi, S., Malvaez, M., Su, H.L., Kleeman, E., Dang, R., Wood, M.A., Sumikawa, K., Sumikawa, K. Early postnatal nicotine exposure causes hippocampus-dependent memory impairments in adolescent mice: Association with altered nicotinic cholinergic modulation of LTP, but not impaired LTP. NEUROBIOLOGY OF LEARNING AND MEMORY 2015; 118(--):178-188. >>> Nicotine; SC; Mice (pregnant); Controls received mp w/ saline; animal info (C57BL6, pregnant); behavioral testing (object location, object recognition memory task, elevated-plus maze; teratology;.

15048 Muldoon, P.P., Chen, J., Harenza, J.L., Abdullah, R.A., Sim-Selley, L.J., Cravatt, B.F., Miles, M.F., Chen, X., Lichtman, A.H., Damaj, M.I., Muldoon, P.P. Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):869-882. >>> Nicotine; SC; Mice; 2002; Controls received mp w/ saline; animal info (male, ICR, 8-10 weeks old); dependence; pumps removed after 14 days;.

15007 Li, J.Y., Bo, L., Zhang, P.J., Gao, Q.Q., Li, L.J., Tang, J.Q., Wu, C.L., Li, D.W., Xiao, J.P., Chen, J., Tao, J.Y., Mao, C.P., Xu, Z.C., Xu, Z.C. Exposure to Nicotine During Pregnancy and Altered Learning and Memory in the Rat Offspring. NICOTINE&TOBACCO RESEARCH 2015; 17(--):661-666. >>> Nicotine; SC; Rat (pregnant); 2ML4; Controls received mp w/ saline; animal info (female, Sprague Dawley, GD4, 300-350g); behavioral testing (morris water maze, escape latency, cross-platform); teratology;.

15030 Leach, P.T., Holliday, E., Kutlu, M.G., Gould, T.J., Gould, T.J. Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice. NICOTINE&TOBACCO RESEARCH 2015; 17(--):690-696. >>> Nicotine; SC; Mice; 1002; Controls received mp w/ vehicle; no stress"Mice were observed to identify any adverse reactions to surgeries (none were observed)"(see pg. 692); behavioral testing (fear conditioning); dependence; pumps removed at 12 days;.

14961 Hawkins, J.L., Denson, J.E., Miley, D.R., Durham, P.L., Durham, P.L. NICOTINE STIMULATES EXPRESSION OF PROTEINS IMPLICATED IN PERIPHERAL AND CENTRAL SENSITIZATION. NEUROSCIENCE 2015; 290(--):115-125. >>> Nicotine; PBS; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 400-500g); functionality of mp verified by cotinine levels; behavioral testing (von Frey filaments); dependence;.

14938 Gao, Z., Nissen, J.C., Legakis, L., Tsirka, S.E., Tsirka, S.E. NICOTINE MODULATES NEUROGENESIS IN THE CENTRAL CANAL DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. NEUROSCIENCE 2015; 297(--):11-21. >>> Nicotine ditartrate; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6); functionality of mp verified by serum cotinine levels; immunology;.

14891 Conceicao, E.P., Peixoto-Silva, N., Pinheiro, C.R., Oliveira, E., Moura, E.G., Lisboa, P.C., Lisboa, P.C. Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring. FOOD AND CHEMICAL TOXICOLOGY 2015; 78(--):52-59. >>> Nicotine; Saline; SC; Rat (lactating); 2ML2; Controls received mp w/ vehicle; animal info (female, Wistar, PN2); teratology; toxicology; dependence;.

14896 Cole, R.D., Poole, R.L., Guzman, D.M., Gould, T.J., Parikh, V., Parikh, V. Contributions of beta2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice. PSYCHOPHARMACOLOGY 2015; 232(--):1207-1217. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (B2 +/-); functionality of mp verified by cotinine ELISA; behavioral testing (visual discrimination, strategy set-shifting, reversal learning);.

14879 Chen, C.M., Chou, H.C., Huang, L.T., Chen, C.M. Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring. PEDIATRIC RESEARCH 2015; 77(--):56-63. >>> Nicotine tartrate; Saline, sterile; SC; Rat (pregnant); 2ML2; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, pregnant, GD7); teratology; used sutures;.

14878 Chen, C.M., Chou, H.C., Huang, L.T., Chen, C.M. Maternal Nicotine Exposure Induces Epithelial-Mesenchymal Transition in Rat Offspring Lungs. Neonatology 2015; 108(--):179-187. >>> Nicotine; SC; Rat; 2ML2; 2ML4; Controls received mp w/ saline; animal info (female, Sprague Dawley); teratology; dependence;.

14838 Barreda, S., Kidder, I.J., Mudery, J.A., Bailey, E.F., Bailey, E.F. Developmental nicotine exposure adversely effects respiratory patterning in the barbiturate anesthetized neonatal rat. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2015; 208(--):45-50. >>> Nicotine bitartrate; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, embryonic day 5); post op. care (antibiotics Pen-48, Buprenex 0.5 mg/kg BID); teratology;.

14827 Ayraam, J., Cohen, G., Drago, J., Frappell, P.B., Ayraam, J. Prenatal nicotine exposure increases hyperventilation in alpha4-knock-out mice during mild asphyxia. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2015; 208(--):29-36. >>> Nicotine bitartrate; Water; SC; Mice; 1002; Animal info (female, a4 nAChR KO or WT, embryonic day14); teratology;.

14823 Alsharari, S.D., King, J.R., Nordman, J.C., Muldoon, P.P., Jackson, A., Zhu, A.Z.X., Tyndale, R.F., Kabbani, N., Damaj, M.I., Kabbani, N. Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. PLoS One 2015; 10(--):U459-U474. >>> Nicotine tartrate salt; Saline; Mice; Controls received mp w/ vehicle; animal info (male, ICR, 20-25g, adult); functionality of mp verified by plasma levels; behavioral testing (tail-flick test; somatic signs; elevated plus-maze); dependence; pumps removed after 7 days;.

14793 Radchenko, E.V., Dravolina, O.A., Bespalov, A.Y., Dravolina, O.A. Agonist and antagonist effects of cytisine in vivo. NEUROPHARMACOLOGY 2015; 95(--):206-214. >>> Nicotine hydrogen tartrate; PBS; SC; Rat; 2ML2; Controls received mp w/ saline; animal info (male, Wistar, adult); behavioral testing (locomotor activity, nicotine self administration); dependence;.

14779 Zhuang, J.G., Zhao, L., Zang, N., Xu, F.D., Xu, F.D. Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2015; 308(--):L922-L930. >>> Nicotine; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced on 7th day of gestation; teratology;.

14765 Xiao, D.L., Huang, X.H., Li, Y., Dasgupta, C., Wang, L., Zhang, L.B., Xiao, D.L. Antenatal Antioxidant Prevents Nicotine-Mediated Hypertensive Response in Rat Adult Offspring. BIOLOGY OF REPRODUCTION 2015; 93(--):U97-U104. >>> Nicotine; Saline; SC; Rat (pregnant); Control animals received mp w/vehicle; animal info (Sprague Dawley, female).

14507 Yildirim, E., Connor, D.A., Gould, T.J., Gould, T.J. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behavioural Pharmacology 2015; 26(--):241-248. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-12 weeks old); behavioral testing (fear conditioning, contextual and cued fear conditioning, five-choice serial reaction time task); dependence; pumps removed after 12 days.

14489 Xiao, C., Miwa, J.M., Henderson, B.J., Wang, Y., Deshpande, P., McKinney, S.L., Lester, H.A., Lester, H.A. Nicotinic Receptor Subtype-Selective Circuit Patterns in the Subthalamic Nucleus. Journal of Neuroscience 2015; 35(--):3734-3746. >>> Nicotine hydrogen tartrate; Saline; SC; Mice (transgenic); 1002; 2002; Controls received mp w/ vehicle; animal info (male, a4-GFP, 5-6 weeks old); dependence;"Nicotine or vehicle (saline) was administered to mice (5- to 6-week-old) by subcutaneously implanted osmotic minipumps (model 1002 or 2002, Alzet) for 7 or 14 d to avoid repetitive handling, which causes stress"pg 3735;.

14428 Tamura, K., Togo, Y., Kaihara, S., Hussain, A., Takahashi, K., Bessho, K., Takahashi, K. The effect of nicotine on osteoinduction by recombinant human bone morphogenetic protein 2. International Journal of Oral and Maxillofacial Surgery 2014; 43(--):1022-1029. >>> Nicotine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 10 weeks old, 250-280g); toxicology;.

14418 Stoker, A.K., Marks, M.J., Markou, A., Markou, A. Null mutation of the beta2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. European Journal of Pharmacology 2015; 753(--):146-150. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, 12-18 weeks old); cardiovascular; pumps removed after 28 days; used wound clips;.

14407 Slotkin, T.A., Card, J., Seidler, F.J., Slotkin, T.A. Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: Sex-selective effects on cerebrocortical serotonergic function. Brain Research Bulletin 2014; 102(--):1-8. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Rat; 1002; 2ML2; Controls received mp w/ vehicle and sodium bitartrate; animal info (Sprague Dawley, PN30); functionality of mp verified by plasma nicotine and cotinine levels; pumps replaced at P90; dependence; used wound clips.

14406 Slotkin, T.A., Skavicus, S., Levin, E.D., Seidler, F.J., Slotkin, T.A. Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. Brain Research Bulletin 2015; 111(--):84-96. >>> Nicotine; Water, bacteriostatic; SC; Rat (pregnant); 2ML2; Controls received mp w/ vehicle; animal info (female, pregnant, Sprague Dawley); teratology; used wound clips.

14405 Slotkin, T.A., Seidler, F.J., Slotkin, T.A. Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: Better, worse, or just"different?". Brain Research Bulletin 2015; 110(--):54-67. >>> Nicotine; Water, bacteriostatic; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (female, pregnant, Sprague Dawley); teratology;"dosage determined by the initial body weights of the dams (215±2 g);control pumps contained bacteriostatic water and equivalent con-centrations of sodium bitartrate. Because weights increased with gestation, the dose rate fell accordingly to 2 mg/kg/day, but the dose rates remained well within the range that produces nicotine plasma levels"pg 55; used wound clips.

14345 Pergadia, M.L., Der-Avakian, A., D'Souza, M.S., Madden, P.A.F., Heath, A.C., Shiffman, S., Markou, A., Pizzagalli, D.A., Pergadia, M.L. Association Between Nicotine Withdrawal and Reward Responsiveness in Humans and Rats. JAMA PSYCHIATRY 2014; 71(--):1238-1245. >>> Nicotine hydrogen tartrate; Saline, sterile; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wistar); stress/adverse reaction: (see pg.1241); behavioral testing (operant chambers withdrawal test); dependence; pumps removed after 28 days;.

14332 Orellana, J.A., Busso, D., Ramirez, G., Campos, M., Rigotti, A., Eugenin, J., von Bernhardi, R., Orellana, J.A. Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet. Frontiers in Cellular Neuroscience 2014; 8(--):U7-U17. >>> Nicotine bitartrate; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (CF1, GD5); dependence;.

14285 Lo, J.O., Schabel, M.C., Roberts, V.H.J., Morgan, T.K., Rasanen, J.P., Kroenke, C.D., Shoemaker, S.R., Spindel, E.R., Frias, A.E., Lo, J.O. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. American Journal of Obstetrics and Gynecology 2015; 212(--):U271-U278. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Monkey (macaque, pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Rhesus, pregnant, GD26); functionality of mp verified by blood levels; pumps replaced every 3 weeks; post op. care (cefazolin 150 mg BID); long-term study; teratology; dependence;.

14256 Qi, X.L., Yamada, H., Corrie, L.W., Ji, Y., Bauzo, R.M., Alexander, J.C., Bruijnzeel, A.W., Bruijnzeel, A.W. A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats. Addiction Biology 2015; 20(--):324-335. >>> Nicotine; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Wistar, 250-300g); dependence;.

14225 Hussmann, G.P., DeDominicis, K.E., Turner, J.R., Yasuda, R.P., Klehm, J., Forcelli, P.A., Xiao, Y.X., Richardson, J.R., Sahibzada, N., Wolfe, B.B., Lindstrom, J., Blendy, J.A., Kellar, K.J., Kellar, K.J. Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine withou maintaining incrased density of nicoticic receptors in rodent brain. Journal of Neurochemistry 2014; 129(--):721-731. >>> Nicotine; sazetidine-A; varenicline; Saline, sterile; SC; Mice; rat; Controls received mp w/ vehicle; animal info (rats male, Sprague Dawley, 8 weeks old, 240g; mice 129SvJ;C57Bl6J F1 hybrid, 6 weeks old, 25-30g); pumps replaced after 2 weeks; behavioral testing (novelty-induced hypophagia test); dependence; used wound clips; new pump inserted in incision 2 cm from first; long-term study;.

14219 Hogan, E.M., Casserly, A.P., Scofield, M.D., Mou, Z.M., Zhao-Shea, R.B., Johnson, C.W., Tapper, A.R., Gardner, P.D., Gardner, P.D. miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family. RNA-A PUBLICATION OF THE RNA SOCIETY 2014; 20(--):1890-1899. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, adult);.

14707 de la Pena, J.B., Ahsan, H.M., Botanas, C.J., Sohn, A., Yu, G.Y., Cheong, J.H., Cheong, J.H. Adolescent nicotine or cigarette smoke exposure changes subsequent response to nicotine conditioned place preference and self-administration. Behavioural Brain Research 2014; 272(--):156-164. >>> Nicotine hydrogen tartrate; Saline; NaOH; SC; Rat; 1007D; 2001; Animal info (male, Sprague Dawley, PD 28 or PD 60); functionality of mp verified by blood levels; dependence; pumps removed after 7 days; used wound clips;.

14694 Chou, H.C., Chen, C.M., Chen, C.M. Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring. REPRODUCTIVE TOXICOLOGY 2014; 50(--):4-10. >>> Nicotine; Saline; SC; Rat (pregnant); 2ML2; 2ML4; Controls received mp w/ vehicle; animal info (female, GD7); functionality of mp verified by blood levels; dose-response (pg 6); teratology; dependence; cardiovascular;.

14629 Poole, R.L., Connor, D.A., Gould, T.J., Gould, T.J. Donepezil Reverses Nicotine Withdrawal-Induced Deficits in Contextual Fear Conditioning in C57BL/6J Mice. Behavioral Neuroscience 2014; 128(--):588-593. >>> Nicotine; SC; Mice; 1002; Control animals received mp w/ saline; animal info (male, C57BL/6J, 10-12 wks old).

14617 Gao, Z., Nissen, J.C., Ji, K.M., Tsirka, S.E., Tsirka, S.E. The Experimental Autoimmune Encephalomyelitis Disease Course Is Modulated by Nicotine and Other Cigarette Smoke Components. PLoS One 2014; 9(--):U735-U748. >>> Nicotine ditartrate; cigarette smoke condensate; DMSO; saline; SC; Mice; 2002; 2004; Control animals received mp w/ vehicle; animal info (C57BL/6); 50% DMSO used;"We compared clinical scores of DMSO- and saline treated mice. There was no difference between these two groups"pg 2.

14578 Mohsenzadeh, Y., Rahmani, A., Cheraghi, J., Pyrani, M., Asadollahi, K., Asadollahi, K. Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat. Mediators of Inflammation 2014; ;(--):U1-U5. >>> Nicotine tartrate; SC; Rat (pregnant); 2ML4; Animal info (female, Wistar, 150-180 g).

13991 Wilkinson, D.S., Gould, T.J. Withdrawal from chronic nicotine and subsequent sensitivity to nicotine challenge on contextual learning. Behavioural Brain Research 2013; 250(-;-):58-61. >>> Nicotine; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 8-12 weeks); behavioral testing (freezing behavior); dependence;"...dose and route of administration was chosen because it produces plasma nicotine levels in the range observed in smokers. In addition, because of the fast half-life of nicotine in the mouse, minipumps produce similar steady state receptor occupancy as in smokers"pg 59; pumps removed after 12 days;.

13982 Varani, A.P., Aso, E., Moutinho, L.M., Maldonado, R., Balerio, G.N., Balerio, G.N. Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations. Psychopharmacology 2014; 231(--):3031-3040. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 2001; 2002; Controls received mp w/ vehicle; animal info (male, Swiss webster, 22-24g); behavioral testing (elevated plus maze, locomotor activity); dependence;.

13974 Turner, J.R., Ray, R., Lee, B., Everett, L., Xiang, J., Jepson, C., Kaestner, K.H., Lerman, C., Blendy, J.A., Blendy, J.A. Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence. Molecular Psychiatry 2014; 19(--):801-810. >>> Nicotine tartrate; Saline, sterile; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, Nrg3ska mice, 6 weeks old, 20-25g); functionality of mp verified by plasma levels; behavioral testing (marble burying, locomotor activity); dependence; used 7mm reflex wound clips; pumps removed after 2 weeks; dosage gave 0.3uM plasma levels;.

13947 Zhang, D., Dragomir, A., Akay, Y.M., Akay, M., Akay, M. Nicotine exposure increases the complexity of dopamine neurons in the parainterfascicular nucleus (PIF) sub-region of VTA. Journal of NeuroEngineering and Rehabilitation 2014; 11(--):U1-U6. >>> Nicotine; Saline; SC; Rat; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, GD5, 280-300g); teratology; dependence;.

13929 Shih, P.Y., Engle, S.E., Oh, G., Deshpande, P., Puskar, N.L., Lester, H.A., Drenan, R.M., Drenan, R.M. Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula. Journal of Neuroscience 2014; 34(--):9789-9802. >>> Nicotine hydrogen tartrate; Saline; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6); functionality of mp verified by immunohistochemical analysis of mecamylamine injection; dependence; pumps removed on day 14; pumps primed;.

13915 Roguski, E.E., Chen, H., Sharp, B.M., Matta, S.G. Fostering itself increases nicotine self-administration in young adult male rats. Psychopharmacology 2013; 229(-2-):227-234. >>> Nicotine hydrogen tartrate; Water; Rat (pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley); pumps replaced after P2 with higher dosage; behavioral testing (locomotor activity, nicotine self-administration); teratology; dependence;.

13895 Parameshwaran, K., Buabeid, M.A., Bhattacharya, S., Uthayathas, S., Kariharan, T., Dhanasekaran, M., Suppiramaniam, V. Long term alterations in synaptic physiology, expression of beta2 nicotinic receptors and ERK1/2 signaling in the hippocampus of rats with prenatal nicotine exposure. NEUROBIOLOGY OF LEARNING AND MEMORY 2013; 106(-;-):102-111. >>> Nicotine; Saline; SC; Rat (pregnant); Controls received mp w/ vehicle; animal info (female, Sprague Dawley, gestation day 3); toxicology; pumps removed after pups born;.

13875 Munoz-Castaneda, R., Diaz, D., vila-Zarza, C.A., Alonso, J.R., Weruaga, E. Sex-influence of nicotine and nitric oxide on motor coordination and anxiety-related neurophysiological responses. Psychopharmacology 2014; 231(-4-):695-706. >>> Nicotine hydrogen tartrate; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (mice, B6129S4-Nos1tmlplh, P75-110 adult); post op. care (heating pad); behavioral testing (open field test, rotarod); Pumps removed at T14;.

13858 Manbeck, K.E., Shelley, D., Schmidt, C.E., Harris, A.C. Effects of oxytocin on nicotine withdrawal in rats. Pharmacology Biochemistry and Behavior 2014; 116(-;-):84-89. >>> Nicotine bitartrate; Saline; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 275-300g); post op. care (buprenorphine injection 0.1 mg/kg; ceftriaxone 5.25 mg); dependence; Used wound clips;.

13838 Kolokotroni, K.Z., Rodgers, R.J., Harrison, A.A. Trait differences in response to chronic nicotine and nicotine withdrawal in rats. Psychopharmacology 2014; 231(-3-):567-580. >>> Nicotine hydrogen tartrate; Saline; SC; Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, Lister hooded, adult); behavioral testing (system delayed reward task; withdrawal behavior); dependence;"Chronic nicotine administration via osmotic mini-pumps mimics more effectively the nicotine intake of smokers by ensuring constant plasma levels throughout the study"pg 568; used wound clips;.

13809 Igari, M., Alexander, J.C., Ji, Y., Qi, X.L., Papke, R.L., Bruijnzeel, A.W. Varenicline and Cytisine Diminish the Dysphoric-Like State Associated with Spontaneous Nicotine Withdrawal in Rats. Neuropsychopharmacology 2014; 39(-2-):445-455. >>> Nicotine; Saline; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 200-225g); behavioral testing (ICSS); dependence; pumps removed after 14 days; used 28 day infusion pumps;.

13804 Henderson, B.J., Srinivasan, R., Nichols, W.A., Dilworth, C.N., Gutierrez, D.F., Mackey, E.D.W., McKinney, S., Drenan, R.M., Richards, C.I., Lester, H.A. Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. Journal of General Physiology 2014; 143(-1-):51-66. >>> Nicotine hydrogen tartrate; Saline; Mice (transgenic); 2002; Animal info (a6-GFP); dependence;.

13788 Gould, T.J., Wilkinson, D.S., Yildirim, E., Blend, J.A., Adoff, M.D., Gould, T.J. Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear. Brain Research 2014; 1559(--):1-10. >>> Nicotine hydrogen tartrate salt; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-12 weeks old); dose-response (pg 7); behavioral testing (freezing behavior, contextual conditioning); dependence; pumps removed after 1-4 days;.

13787 Gorini, C., Jameson, H., Woerman, A.L., Perry, D.C., Mendelowitz, D. Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways. Journal of Applied Physiology 2013; 115(-4-):415-421. >>> Nicotine; Rat (pregnant); Animal info (female, Sprague Dawley, adult, third day of gestation); teratology; dependence;.

13746 Colombo, E.S., Davis, J., Makvandi, M., Aragon, M., Lucas, S.N., Paffett, M.L., Campen, M.J. Effects of Nicotine on Cardiovascular Remodeling in a Mouse Model of Systemic Hypertension. Cardiovascular Toxicology 2013; 13(-4-):364-369. >>> Nicotine; angiotensin II; Saline; SC; Mice; 2ML4; Controls received mp w/ vehicle; animal info (male, C57BL6, 8 weeks old); stress/adverse reaction: (see pg.366); cardiovascular; peptides; Wound clips;.

13729 Carcoba, L.M., Orfila, J.E., Natividad, L.A., Torres, O.V., Pipkin, J.A., Ferree, P.L., Castaneda, E., Moss, D.E., O'Dell, L.E., O'Dell, L.E. Cholinergic Transmission during Nicotine Withdrawal Is Influenced by Age and Pre-Exposure to Nicotine: Implications for Teenage Smoking. Developmental Neuroscience 2014; 36(--):347-355. >>> Nicotine hydrogen tartrate; SC; Rat; 2ML2; Controls received sham surgery; animal info (male, Wistar, adult PND 60-74; adolescent PND 28-42); post op. care (topical antibiotic ointment); dependence; pumps removed after 14 days; used 9mm wound clips;.

13709 vila-Ruiz, T., Carranza, V., Lopez-Lopez, G., Limon, D.I., Martinez, I., Flores, G., Flores-Hernandez, J., Flores-Hernandez, J. Chronic Administration of Nicotine Enhances NMDA-Activated Currents in the Prefrontal Cortex and Core Part of the Nucleus Accumbens of Rats. Synapse 2014; 68(--):248-256. >>> Nicotine; Tartrate salt; SC; Rat; 2ML2; Animal info (male, Sprague Dawley, 250-300g); functionality of mp verified by blood plasma; behavioral testing (open field test); 4.23 mg/kg/day of nicotine tartrate salt is equivalent to 1 mg/kg/day free nicotine;.

13683 Bordia, T., McGregor, M., Papke, R.L., Decker, M.W., McIntosh, J.M., Quik, M., Quik, M. The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental Neurology 2015; 263(--):277-284. >>> Nicotine; ABT-107; DMXB; Rat; 2006; Control animals received mp w/ vehicle; animal info (male, Sprague Dawley, 120-140 g); neurodegenerative (Parkinson's disease).

13577 Han, Y., Ling, M.T., Mao, H.W., Zheng, J., Liu, M., Lam, K.T., Liu, Y., Tu, W.W., Lau, Y.L. Influenza Virus-Induced Lung Inflammation Was Modulated by Cigarette Smoke Exposure in Mice. PLoS One 2014; 9(-1-):U1912-U1925. >>> Nicotine; SC; Mice; 1004; Control animals received mp w/ sterile water; animal info (female, 6-8 wks old, C57B6N).

13531 Ignatowska-Jankowska, B.M., Muldoon, P.P., Lichtman, A.H., Damaj, M.I. The cannabinoid CB(2) receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology 2013; 229(-4-):591-601. >>> Nicotine; Saline; Mice; 1007D; Controls received mp w/ vehicle; animal info (CB2 null and WT, C57BL6); behavioral testing (tail flick test; plus maze test; chamber bias); dependence;.

13524 Paccola, C.C., Neves, F.M.O., Cipriano, I., Stumpp, T., Miraglia, S.M. Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue. ANDROLOGY 2014; 2(-2-):175-185. >>> Nicotine; Water, bacteriostatic; SC; Rat (pregnant); 2ML4; Control animals received no pump; cyanoacrylate used;"The subcutaneous osmotic minipump is considered the best way to have a chronic release of nicotine in rats (Murrin et al., 1987) because it does not cause vasoconstriction in the uterus and placenta and avoids additional negative effects, which would occur by daily manipulation and injection"pg 176;.

13498 Dickson, P.E., Miller, M.M., Rogers, T.D., Blaha, C.D., Mittleman, G. Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice. Addiction Biology 2014; 19(-1-):37-48. >>> Nicotine; Water, sterile; SC; Mice; 1004; Control animals received mp w/ vehicle; animal info (C57BL/6, P28); stress/adverse effects ("one nicotine-exposed and one vehicle-exposed mouse were dropped from the study because the implanted pumps became externalized."pg 40.

13487 Fowler, C.D., Tuesta, L., Kenny, P.J. Role of alpha5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. Psychopharmacology 2013; 229(-3-):503-513. >>> Nicotine, (-) hydrogen tartrate salt; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, alpha5 nAChR subunit null mutation, 6 weeks old); post op. care (Metacam 0.2 mg/kg); behavioral testing (taste aversion, ICSS threshold); dependence;.

13483 Dao, D.Q., Perez, E.E., Teng, Y.F., Dani, J.A., De Biasi, M. Nicotine Enhances Excitability of Medial Habenular Neurons via Facilitation of Neurokinin Signaling. Journal of Neuroscience 2014; 34(-12-):4273-4284. >>> Nicotine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (female, nursing, C576L/6J); no stress (see pg. 4278); behavioral testing (activity log); dependence; receipt of nicotine in pups from mother confirmed through blood serum.

13191 Cao, J., Wang, J., Dwyer, J.B., Gautier, N.M., Wang, S., Leslie, F.M., Li, M.D. Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differences. TRANSLATIONAL PSYCHIATRY 2013; 3(-;-):U33-U42. >>> Nicotine; SC; Rat (pregnant); 2002; Controls received mp w/ saline; dependence; animal info (Sprague Dawley, pregnant, delivery started from gestation day 4); teratology.

13182 Alajaji, M., Bowers, M.S., Knackstedt, L., Damaj, M.I. Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice. Psychopharmacology 2013; 228(-3-):419-426. >>> Nicotine; SC; Mice; 1007D; Controls received mp w/ saline; dependence; animal info (male, 8-10 wks old, ICR); behavioral testing (antinociception: tail flick test, hot plates).

13174 Wang, H., Gondre-Lewis, M.C. Prenatal Nicotine and Maternal Deprivation Stress De-Regulate the Development of CA1, CA3, and Dentate Gyrus Neurons in Hippocampus of Infant Rats. PLoS One 2013; 8(-6-):U924-U939. >>> Nicotine hydrogen tartrate; Saline; SC; Mice (pregnant); 2004; 2006; Controls received mp w/ saline; animal info (pregnant dams); teratology.

13148 Bordia, T., McIntosh, J.M., Quik, M. The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release. Journal of Neurochemistry 2013; 125(-2-):291-302. >>> Nicotine; SC; Rat; 2006; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, adult, 200-250 g); pumps replaced every 2 months; long-term study.

13107 Henley, B.M., Williams, B.A., Srinivasan, R., Cohen, B.N., Xiao, C., Mackey, E.D.W., Wold, B.J., Lester, H.A. Transcriptional regulation by nicotine in dopaminergic neurons. Biochemical Pharmacology 2013; 86(-8-):1074-1083. >>> Nicotine; Mice; 2002; Control animals received mp w/ saline; animal info (C57BL/6, 4 mo old, male).

13088 Chang, G.Q., Karatayev, O., Leibowitz, S.F. Prenatal Exposure to Nicotine Stimulates Neurogenesis of Orexigenic Peptide-Expressing Neurons in Hypothalamus and Amygdala. Journal of Neuroscience 2013; 33(-34-):13600-13611. >>> Nicotine; Saline; SC; Rat (pregnant); 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, female, 220-240 g); teratology.

 

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“In summary, our data demonstrate that the local microinfusion of endostatin is able to inhibit tumor growth and increase survival of animals with orthotopic malignant gliomas. Local continuous i.c. delivery is more effective than daily systemic delivery.” (p.1255) Schmidt et al., Clinical Cancer Research 2004;10:1255-1262.