References on the Administration of Norepinephrine Using ALZET® Osmotic Pumps

16255 Matsuda S,, Umemoto S,, Yoshimura K,, Itoh S,, Murata T,, Fukai T,, Matsuzaki M. AngiotensinⅡ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4. Journal of Atherosclerosis and Thrombosis 2015; 228(-8-):833-844. >>> Angiotensin II, Norepinephrine; Saline, physiological; SC; mice; 1002; Controls received mp w/ vehicle; animal info (male, 12-16 wks, WT Balb/c mice); functionality of mp verified by ECG; cardiovascular; peptides; peptides; Dose (Ang II– 1.1 mg/kg/day, Norepinephrine – 5.6 mg/kr/day);.

16122 Fry, J. L., Shiraishi, Y., Turcotte, R., Yu, X., Gao, Y. Z., Akiki, R., Bachschmid, M., Zhang, Y., Morgan, K. G., Cohen, R. A., Seta, F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc 2015; 4(-9-):e002384. >>> Angiotensin II; Norepinephrine; Saline; Ascorbate; SC; mice; 1007D; 1002; animal info: WT, SMKO, and SMTg mice aged 8 weeks (C57Bl/6J genetic background); functionality of mp verified by radiotelemetry; 1 mmol/L ascorbate; cardiovascular; antihypertensive, norepinephrine; Dose: 1 mg/kg per day of AngII; 10 mg/kg per day of norepinephrine.

15919 Nakashima, T., Umemoto, S., Yoshimura, K., Matsuda, S., Itoh, S., Murata, T., Fukai, T., Matsuzaki, M. TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase. Hypertens Res 2015; 38(-10-):649-55. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, WT, 12-16 weeks old); cardiovascular; peptides; bp measured using tail cuff; Dose (Angiotensin II 1.1 mg/kg/day; norepinephrine 5.6 mg/kg/day);.

15835 Kathryn R. Walsh, Jill T. Kuwabara, Joon W. Shim, and Richard D. Wainford  Am J Physiol Regul Integr Comp Physiol 2016; 310(--):R115-R124. >>> Norepinephrine; hydrochlorothiazide; losartan; Saline; DMSO; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 275-299g); post op. care (penicillin 0.3 ml IM 300,000 units/ml); cardiovascular; Dose (losartan 3 mg/kg/day, NE 600 ng/min; HCTZ 4 mg/kg/day);.

15736 Kathrin Broekmans,, Johannes Stegbauer,, Sebastian A. Potthoff,, Michael Russwurm,, Doris Koesling,, and Evanthia Mergia  The Journal of Pharmacology and Experimental Therapeutics 2016; (-356-):191-199. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 1002; animal info (male, NO-GC1 KO, 2-3 months old); cardiovascular; peptides; bp measured using tail cuff or radiotelemetry (DSI); Dose (Ang II 1.44 mg/kg/day; NE 2.88 mg/kg/day);good bp graph;.

15074 Schmit, B.M., Yang, P., Fu, C.H., DeSart, K., Berceli, S.A., Jiang, Z.H., Jiang, Z.H. Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H115-H125. >>> Norepinephrine; Mice; 2004; Animal info (Alk5 iko or Alk5 f/f or C57BL6, 7-15 weeks old, OVX or ORX); cardiovascular; bp measured using tail cuff;.

15011 Liu, J., Deng, G.H., Zhang, J., Wang, Y., Xia, X.Y., Luo, X.M., Deng, Y.T., He, S.S., Mao, Y.Y., Peng, X.C., Weil, Y.Q., Jiang, Y., Jiang, Y. The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models. PSYCHONEUROENDOCRINOLOGY 2015; 52(--):130-142. >>> Norepinephrine bitartrate hydrate; propranolol; Ascorbic acid; PBS; SC; Mice; 1004; Animal info (female, BALB/c, 5-7 weeks old); cancer (colorectal carcinoma, human);.

15003 Lee, Y.H., Petkova, A.P., Konkar, A.A., Granneman, J.G., Granneman, J.G. Cellular origins of cold-induced brown adipocytes in adult mice. FASEB JOURNAL 2015; 29(--):286-299. >>> Norepinephrine; uridine, 5-bromo-2'-deoxyuridine; Ascorbic acid; Mice; Controls received mp w/ vehicle; animal info (C57BL6J or tdTomato);.

14889 Choi, M.J., Cho, K.H., Lee, S., Bae, Y.J., Jeong, K.J., Rha, S.Y., Choi, E.J., Park, J.H., Kim, J.M., Lee, J.S., Mills, G.B., Lee, H.Y., Lee, H.Y. hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. ONCOGENE 2015; 34(--):3402-3412. >>> Norepinephrine; Saline; ascorbic acid; SC; Mice (nude); 1004; Controls received mp w/ vehicle; animal info (female, nude, 4 weeks old); cancer (ovarian);.

14360 Rateri, D.L., Davis, F.M., Balakrishnan, A., Howatt, D.A., Moorleghen, J.J., O'Connor, W.N., Charnigo, R., Cassis, L.A., Daugherty, A., Daugherty, A. Angiotensin II Induces Region-Specific Medial Disruption during Evolution of Ascending Aortic Aneurysms. American Journal of Pathology 2014; 184(--):2586-2595. >>> Angiotensin II; norepinephrine; Saline; ascorbic acid; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J or Ldlr-/-); post op. care (topical anesthetic cream); cardiovascular; peptides; bp measured using tail cuff;.

14684 Case, A.J., Zimmerman, M.C., Zimmerman, M.C. Redox-Regulated Suppression of Splenic T-Lymphocyte Activation in a Model of Sympathoexcitation. Hypertension 2015; 65(--):916-+. >>> Norepinephrine; SC; Mice; 1002; Controls received mp w/ saline; animal info (male, C57BL6, 20-25g, 8-12 weeks old); functionality of mp verified by plasma levels; good methods (see supplement); post op. care (incision cleaned with iodine); cardiovascular; immunology; bp measured using radiotelemetry (DSI);.

13954 Xiao, D.L., Dasgupta, C., Chen, M., Zhang, K.L., Buchholz, J., Xu, Z.C., Zhang, L.B. Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats. Cardiovascular Research 2014; 101(-3-):373-382. >>> Norepinephrine; Rat; 2ML4; Controls received mp w/saline; animal info (male, Sprague Dawley, 6 months old); functionality of mp verified by plasma levels pg.375; dose-response (pg735, table 1); cardiovascular; arterial blood pressure measured using catheter in femoral artery;.

13777 Gao, Y.X., Yu, C.A., Lu, J.H., Gao, H.M., Li, G., Kong, W., Zheng, J.G., Zheng, J.G. ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice. KIDNEY&BLOOD PRESSURE RESEARCH 2014; 38(--):121-131. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57Bl6, 36 weeks old); functionality of mp verified by increased bp; cardiovascular; immunology; peptides; bp measured using tail-cuff;.

13591 Chen, J., Zhao, Y.H., Chen, S.Z., Wang, J.J., Xiao, X., Ma, X.T., Penchikala, M., Xia, H.J., Lazartigues, E., Zhao, B., Chen, Y.F. Neuronal over-expression of ACE2 protects brain from ischemia-induced damage. Neuropharmacology 2014; 79(-;-):550-558. >>> Norepinephrine; A-779; Cerebrospinal fluid, artificial; CSF/CNS; Mice (transgenic); Controls received mp w/ vehicle; animal info (male, SARA or RA transgenic, 6-10 weeks); ALZET brain infusion kit used; ischemia (cerebral); cardiovascular; Pumps primed overnight in 37C saline;.

13484 Deng, G.H., Liu, J., Zhang, J., Wang, Y., Peng, X.C., Wei, Y.Q., Jiang, Y. Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model. JOURNAL OF EXPERIMENTAL&CLINICAL CANCER RESEARCH 2014; 33(-;-):U1-U12. >>> Norepinephrine; propranolol; Ascorbic acid; saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (Female, C57BL6, 4-6 weeks old); cancer (melanoma; adenocarcinoma); immunology;"Seeing that microosmotic pumps (1004 type) are of the ability of pumping drugs contained incessantly for up to 4 weeks and exhibit reliable effects in mouse models, the pumps were taken into account in our research to deal with the short half life period of NE."pg 7; Primed pumps in 37C saline for 48 hours; Picture on pg 6 of pump and tumor on mouse..

13333 Marvar, P.J., Thabet, S.R., Guzik, T.J., Lob, H.E., McCann, L.A., Weyand, C., Gordon, F.J., Harrison, D.G. Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-Induced Hypertension. Circulation Research 2010; 107(-2-):263-U186. >>> Angiotensin II; norepinephrine; Mice; 2002; Controls received mp w/ vehicle; animal info (C57BL/6, RAG1 -/-, OVA-specific, OT-II tg); peptides; blood pressure measured via telemetry or tail cuff.

12983 Kurihara, T., Shimizu-Hirota, R., Shimoda, M., Adachi, T., Shimizu, H., Weiss, S.J., Itoh, H., Hori, S., Aikawa, N., Okada, Y. Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection. Circulation 2012; 126(-25-):3070-U532. >>> Angiotensin II; norepinephrine; SC; Mice; Animal info (MMP9 -/-, 7 wks old); peptides.

12106 Wu, Q., Whiddon, B.B., Palmiter, R.D. Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012; 109(-8-):3155-3160. >>> Norepinephrine; Ascorbate; SC; Mice; 1002; Animal info (Lep Ob+, 55 g, 14 wks old).

11816 Kimura, K., Kanazawa, H., Ieda, M., Kawaguchi-Manabe, H., Miyake, Y., Yagi, T., Arai, T., Sano, M., Fukuda, K. Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure. Autonomic Neuroscience-Basic&Clinical 2010; 156(-1-2-):27-35. >>> Norepinephrine; Saline; ascorbate; SC; Rat; mice; 2004; Controls received mp w/ vehicle; animal info (Wistar, male, 240-260 g, 7 wks old; 5 wks old, DBH-Cre/Floxed-EGFP); functionality of mp verified by plasma NE levels.

11527 Penn, A., Mohr, A.M., Shah, S.G., Sifri, Z.C., Kaiser, V.L., Rameshwar, P., Livingston, D.H. Dose-Response Relationship between Norepinephrine and Erythropoiesis: Evidence for a Critical Threshold. Journal of Surgical Research 2010; 163(-2-):E85-E90. >>> Norepinephrine bitartrate;; Saline; IP; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 300-350 g).

11515 Mu, S., Shimosawa, T., Ogura, S., Wang, H., Uetake, Y., Kawakami-Mori, F., Marumo, T., Yatomi, Y., Geller, D.S., Tanaka, H., Fujita, T. Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nature Medicine 2011; 17(-5-):573-U92. >>> Norepinephrine; isoproterenol; ICI 118,551; metoprolol; SC; Mice; rat; Controls received mp w/ vehicle; animal info (C57BL/6j, male, Sprague Dawley, 250-270 g, 8 wks old, nephrectomy).

11408 Ishizaka, N., Hongo, M., Sakamoto, A., Saito, K., Furuta, K., Koike, K. Liver lipid content is reduced in rat given 7-day administration of angiotensin II. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 2011; 12(-4-):462-468. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; animal info (male, Sprague Dawley, 10 wks old); peptides.

10780 Mobine, H.R., Baker, A.B., Wang, L.B., Wakimoto, H., Jacobsen, K.C., Seidman, C.E., Seidman, J.G., Edelman, E.R. Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors. Circulation-Heart Failure 2009; 2(-2-):121-128. >>> Norepinephrine; Ascorbic acid; saline; IP; Mice; rat; 2004; 1004; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 8 wks old, 250 g; female, black-6, 7 -8 wks old, 15-20 g).

10218 Owens, AP III, Subramanian, V., Moorleghen, J.J., Guo, Z.H., McNamara, C.A., Cassis, L.A., Daugherty, A. Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3. Circulation Research 2010; 106(-3-):611-U108. >>> Angiotensin II; norepinephrine; losartan; Saline; Mice; Controls received mp w/vehicle; peptides; cardiovascular; animal info (male, C57BL/6, AT1aR -/-, p47phox -/-, Id3 -/-); functionality of mp verified by systolic blood pressure.

9869 Mobine, H.R., Engelmayr, GC Jr, Moussazadeh, N., Anwar, T.R., Freed, L.E., Edelman, E.R. Encapsulated Pheochromocytoma Cells Secrete Potent Noncatecholamine Factors. Tissue Engineering Part A 2009; 15(-7-):1719-1728. >>> Norepinephrine; Saline; ascorbic acid; IP; Rat; 2004; Controls received mp w/vehicle; animal info (female, Sprague-Dawley, 8 wks, 230g).

9800 Meier, H., Bullinger, J., Marx, G., Deten, A., Horn, L.C., Rassler, B., Zimmer, H.G., Briest, W. Crucial Role of Interleukin-6 in the Development of Norepinephrine-induced Left Ventricular Remodeling in Mice. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2009; 23(-4-6-):327-334. >>> Norepinephrine; SC; Mice; Controls received unfilled mp; animal info (IL-6 -/-, IL-6 +/+).

9736 Hongo, M., Ishizaka, N., Furuta, K., Yahagi, N., Saito, K., Sakurai, R., Matsuzaki, G., Koike, K., Nagai, R. Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart. European Journal of Pharmacology 2009; 604(-1-3-):87-92. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; Peptides; animal info (male, Sprague Dawley, 250-300 g.).

9490 Qin, Z.Y., Gongora, M.C., Ozumi, K., Itoh, S., Akram, K., Ushio-Fukai, M., Harrison, D.G., Fukai, T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

9128 Ishizaka, N., Matsuzaki, G., Saito, K., Noiri, E., Mori, I., Nagai, R. Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat. LABORATORY INVESTIGATION 2006; 86(-12-):1285-1292. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; 2001; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 250-300 g.); nephrology.

8836 Ming, X.U., YanTing, Z., TianPao, H.A.O., Yao, S., ZhiZhen, L.U., QiDe, H.A.N., ShiQiang, W., YouYi, Z. Alpha 1-adrenergic receptors activate AMP-activated protein kinase in rat hearts. Acta Physiologica Sinica 2007; 59(-2-):175-182. >>> Norepinephrine; phenylephrine; Vitamin C; SC; Rat; 2002; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, 330-440 grams, 12 weeks old).

8822 Dao, H.H., Martens, F.M., Lariviere, R., Yamaguchi, N., Cernacek, P., De Champlain, J., Moreau, P. Transient involvement of endothelin in hypertrophic remodeling of small arteries. J Hypertens 2001; 19(-10-):1801-1812. >>> Norepinephrine; angiotensin II; SC; Rat; 2002; 2004; Functionality of mp verified by plasma NE levels and blood pressure; cardiovascular; peptides; animal info (Sprague-Dawley, 175-200 grams).

8811 Garg, P., Martin, C.F., Elms, S.C., Gordon, F.J., Wall, S.M., Garland, C.J., Sutliff, R.L., O'Neill, W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. American Journal of Physiology- Heart and Circulatory Physiology 2007; 292(-5-):H2100-H2105. >>> Norepinephrine; SC; Rat; 2001; Functionality of mp verified by mean arterial blood pressure; cardiovascular; animal info (male, Sprague-Dawley, 360 grams).

8738 Ko, E.A., Amiri, F., Pandey, N.R., Javeshghani, D., Leibovitz, E., Touyz, R.M., Schiffrin, E.L. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1789-H1795. >>> Norepinephrine; Mice; Replacement therapy (nephrectomy); dose-response (fig 3); cardiovascular; animal info (OP+, 3-4 months old, 20-35 g).

8720 Ideura, H., Hiromura, K., Hiramatsu, N., Shigehara, T., Takeuchi, S., Tomioka, M., Sakairi, T., Yamashita, S., Maeshima, A., Kaneko, Y., Kuroiwa, T., Kopp, J.B., Nojima, Y. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1214-F1221. >>> Angiotensin II; norepinephrine; SC; Mice (transgenic); 2004; Functionality of mp verified by blood pressure; cardiovascular; peptides; animal info (FVB/N Podocin/rt TA tg, 7-8 wks old, 20-25g) nephrology.

8621 Zhao, W.Y., Swanson, S.A., Ye, J.F., Li, X.L., Shelton, J.M., Zhang, W.G., Thomas, G.D. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 2006; 48(-4-):637-643. >>> Angiotensin II; norepinephrine; SC; Rat; 2002; Controls received mp w/ vehicle, or sham surgery; cardiovascular; peptides; animal info (Sprague-Dawley, 200-300g., unilateral renal artery stenosis).

8206 Wolf, G., Bohlender, J., Bondeva, T., Roger, T., Thaiss, F., Wenzell, U.O. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Journal of the American Society of Nephrology 2006; 17(-6-):1585-1593. >>> Angiotensin II; norepinephrine; IP; Rat; 2002; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 200g.); nephrology.

8202 Eagleton, M.J., Ballard, N., Lynch, E., Srivastava, S.D., Upchurch, GR Jr, Stanley, J.C. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. Journal of Surgical Research 2006; 135(-2-):345-351. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6J wt or ApoE -/-, male, 8-6 months old).

8255 Vongpatanasin, W., Thomas, G.D., Schwartz, R., Cassis, L.A., Osborne-Lawrence, S., Hahner, L., Gibson, L.L., Black, S., Samols, D., Shaul, P.W. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 2007; 115(-8-):1020-1028. >>> Angiotensin II; norepinephrine; SC; Mice; 2002; Blood pressure taken; cardiovascular; peptides; animal info (CF1-CRP).

8016 Palm, D., Lang, K., Niggemann, B., Drell, T.L., Masur, K., Zaenker, K.S., Entschladen, F. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by betablockers. International Journal of Cancer 2006; 118(-11-):2744-2749. >>> Norepinephrine; propranolol; Saline, physiological; ascorbic acid; SC; Mice (nude); 1002; Controls received mp w/ vehicle; pumps replaced after 2 weeks; half-life (pg. 2745) short, quickly metabolized; cancer (prostate carcinoma); animal info (female, BALB/C nude, athymic, 6 wk. old, 15g.).

7955 Saito, K., Ishizaka, N., Aizawa, T., Sata, M., Iso-o, N, Noiri, E., Mori, I., Ohno, M., Nagai, R. Iron chelation and a free radical scavenger suppress angiotensin II- induced upregulation of TGF-beta 1 in the heart. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-4-):H1836-H1843. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; Controls received no treatment; cardiovascular; animal info (male, Sprague-Dawley).

7807 Ishizaka, N., Saito, K., Mori, I., Matsuzaki, G., Ohno, M., Nagai, R. Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II - Infused rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-11-):2282-2288. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; 2001; Controls received no treatment; dose-response (fig. 1); cardiovascular; peptides; animal info (male, Sprague-Dawley).

7791 Chen, Y., Currie, R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

7737 Saito, K., Ishizaka, N., Hara, M., Matsuzaki, G., Sata, M., Mori, I., Ohno, M., Nagai, R. Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II. Hypertension 2005; 46(-5-):1180-1185. >>> Angiotensin II, [Val 5]; norepinephrine; SC; Rat; 2001; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-300 g); lipotoxicity.

7650 Ayabe, N., Babaev, V.R., Tang, Y.W., Tanizawa, T., Fogo, A.B., Linton, M.F., Ichikawaa, I., Fazio, S., Kon, V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 2006; 184(-2-):312-321. >>> Angiotensin II; norepinephrine; SC; Mice; 1002; Controls received mp w/ saline; dose-response (fig.1); stress/adverse reaction: (see pg. 313) 2 animals of 105 had mp extrusion; cardiovascular; peptides; animal info (female, C57BL/6, 8 weeks old).

7289 Li, Z.P., Oben, J.A., Yang, S.Q., Lin, H.Z., Stafford, E.A., Soloski, M.J., Thomas, S.A., Diehl, A.M. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 2004; 40(-2-):434-441. >>> Norepinephrine; Saline, pyrogen-free; Mice; Controls received mp w/ vehicle.

6701 Chen, Y., Ross, B.M., Currie, R.W. Heat shock treatment protects against angiotensin II-induced hypertension and inflammation in aorta. CELL STRESS&CHAPERONES 2004; 9(-1-):99-107. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (vena cava); Rat; 2001; 2002; 2ML2; Controls received empty mp for 7 days; functionality of mp verified by SBP; cardiovascular; peptides.

6655 Oben, J.A., Roskams, T., Yang, S., Lin, H., Sinelli, N., Torbenson, M., Smedh, U., Moran, T.H., Li, Z., Huang, J., Thomas, S.A., Diehl, A.M. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 2004; 53(-3-):438-445. >>> Isoprenaline; norepinephrine; SC; Mice; Controls received mp w/ vehicle.

6604 Van Landeghem, F.K.H., Schreiber, S., Unterberg, A.W., Von Deimling, A., Stover, J.F. Differential concentration-dependent effects of prolonged norepinephrine infusion on intraparenchymal hemorrhage and cortical contusion in brain-injured rats. Journal of Neurotrauma 2003; 20(-12-):1327-1337. >>> Norepinephrine; Saline; IV; Rat; 2001; Controls received mp w/ vehicle; blood pressure taken; dose-response (p. 1329); brain injury.

6247 Saito, K., Ishizaka, N., Mitani, H., Ohno, M., Nagai, R. Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Letters 2003; 551(-1-3-):58-62. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; Peptides.

6239 Li, P., Li, J., Feng, X., Li, Z., Hou, R., Han, C., Zhang, Y. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. CELLULAR AND MOLECULAR LIFE SCIENCES 2003; 60(-10-):2200-2209. >>> Norepinephrine; Ascorbic acid; IV (jugular); Rat; 2002; Functionality of mp verified by liquid chromatography; cardiovascular.

6189 Mardon, K., Montague, O., Elbaz, N., Malek, Z., Syrota, A., Dubois-Rande, J.L., Meignan, M., Merlet, P. Uptake-1 carrier downregulates in parallel with theβ-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: Implications for cardiac neuroimaging in human cardiomyopathies. Journal of Nuclear Medicine 2003; 44(-9-):1459-1466. >>> Norepinephrine; Saline; IV (jugular); Rat; 2001; Controls received mp w/ vehicle; cardiovascular; silastic catheter used.

5994 Caprile, T., Hein, S., Rodriguez, S., Montecinos, H., Rodriguez, E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. MOLECULAR BRAIN RESEARCH 2003; 110(-2-):177-192. >>> Serotonin, binoxaiate; Norepinephrine; serotonin trifluoroacetate; Serotonin creatinin sulfate; L-DOPA; CSF, artificial; radio-isotopes; 3H tracer; CSF/CNS; Rat; 2001; .

5879 Briest, W., Holzl, A., Rassler, B., Deten, A., Baba, H.A., Zimmer, H.G. Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts. Cardiovascular Research 2003; 57(-2-):379-387. >>> Norepinephrine; Saline; Ascorbic Acid; IV (jugular); Rat; Controls received mp w/ vehicle; cardiovascular; Norepinephrine is also called Noradrenalin; ascorbic acid added to vehicle solution to prevent oxidation.

5805 Festuccia, W.T.L., Guerra-Sa, R., Kawashita, N.H., Garofalo, M.A.R., Evangelista, E.A., Rodrigues, V., Kettelhut, I.C., Migliorini, R.H. Expression of glycerokinase in brown adipose tissue is stimulated by the sympathetic nervous system. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-6-):R1536-R1541. >>> Norepinephrine; dobutamine; isoproterenol; Saline; sodium metabisulfite; SC; Rat; 2002; Controls received mp w/ vehicle; the norepinephrine vehicle solution contained sodium metabisulfite as an antioxidant; the b-adrenergic agonists (isoproterenol, dobutamine, and CL316243) were dissolved in saline and infused over 3 days..

5722 Golden, K.L., Ren, J., Dean, A., Marsh, J.D. Norepinephrine regulates the in vivo expression of the L-type calcium channel. MOLECULAR AND CELLULAR BIOCHEMISTRY 2002; 236(-1-2-):107-114. >>> Isoproterenol; Norepinephrine; Phenylephrine; HCl; SC; rat; controls received mp with vehicle; alpha&beta adrenergic agonist.

5605 Erami, C., Zhang, H., Ho, J.G., French, D.M., Faber, J.E. Alpha 1-adrenoceptor stimulation directly induces growth of vascular wall in vivo. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-4-):H1577-H1587. >>> Norepinephrine; benoxathian; prazosin; KMD-3213; AH11110A; BMY-7378; propranolol; RX-821002; Ringer's, lactated; ascorbate; Perivascular; Rat; 2ML2; Tissue perfusion (left carotid wall); pumps replaced after 14 days for prazosin; catheter constructed from thin walled vinyl tubing and fenestrated at end placed near vessel; norepinephrine is a catecholamine; propranolol is a beta adrenoceptor antagonist; all other agents are antagonists alpha antagonists.

5584 Ishizaka, N., Saito, K., Mitani, H., Yamazaki, I., Sata, M., Usui, S., Mori, I., Ohno, M., Nagai, R. Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. Circulation 2002; 106(-14-):1840-1846. >>> Angiotensin II; hydralazine; losartan; norepinephrine; SC; Rat; 2001; Antihypertensive.

5534 Bonnefont-Rousselot, D., Mahmoudi, A., Mougenot, N., Varoquaux, O., Le Nahour, G., Fouret, P., Lechat, P. Catecholamine effects on cardiac remodelling, oxidative stress and fibrosis in experimental heart failure. REDOX REPORT 2002; 7(-3-):145-151. >>> Norepinephrine; Saline; SC; Rat; Controls received mp w/ vehicle; functionality of mp verified by norepinephrine plasma levels (p.148); cardiovascular; also called noradrenalin (a catecholamine).

5358 Mitani, H., Ishizaka, N., Aizawa, T., Ohno, M., Usui, S., Suzuki, T., Amaki, T., Mori, I., Nakamura, Y., Sato, M., Nangaku, M., Hirata, Y., Nagai, R. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002; 39(-4-):838-843. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; Peptides.

5351 Ishizaka, N., Aizawa, T., Ohno, M., Usui, Si S., Mori, I., Tang, S.S., Ingelfinger, J.R., Kimura, S., Nagai, R. Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. Hypertension 2002; 39(-1-):122-128. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; Peptides.

5349 Aizawa, T., Ishizaka, N., Usui, S., Ohashi, N., Ohno, M., Nagai, R. Angiotensin II and catecholamines increase plasma levels of 8-epi- prostaglandin F(2alpha) with different pressor dependencies in rats. Hypertension 2002; 39(-1-):149-154. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; 2001; Dose-response (p. 151); cardiovascular; peptides.

5320 Briest, W., Holzl, A., Rassler, B., Deten, A., Leicht, M., Baba, H.A., Zimmer, H.G. Cardiac remodeling after long term norepinephrine treatment in rats. Cardiovascular Research 2001; 52(--):265-273. >>> Norepinephrine; nisoldipin; Saline; ascorbic acid; ethanol; IP; IV (jugular); Rat; Controls received mp w/ vehicle; comparison of infusion pump vs. mp; cardiovascular; Norepinephrine was infused IV for 14 days in saline w/ 0.01% ascorbic acid; nisoldipin, a calcium channel blocker, was delivered IP for 3 days in absolute ethanol.

5287 Moser, L., Faulhaber, J., Wiesner, R.J., Ehmke, H. Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 282(--):R1389-R1394. >>> Angiotensin II; Norepinephrine; SC; rat; 2001; cardiovascular.

5194 Wenzel, U.O., Thaiss, F., Helmchen, U., Stahl, R.A.K., Wolf, G. Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis. Kidney International 2002; 61(--):1020-1029. >>> Angiotensin II; Norepinephrine; SC; rat; 2002; peptides; all animals received either Ang II or NE.

5192 Vecchione, C., Fratta, L., Rizzoni, D., Notte, A., Poulet, R., Porteri, E., Frati, G., Guelfi, D., Trimarco, V., Mulvany, M.J., Agabiti-Rosei, E., Trimarco, B., Cotecchia, S., Lembo, G. Cardiovascular influences of alpha 1b-adrenergic receptor defect in mice. Circulation 2002; 105(-14-):1700-1707. >>> Angiotensin II; Norepinephrine; Phenylephrine; Saline; Ascorbic acid; SC; mice (transgenic); 2004; controls received mp w/ vehicle; cardiovascular; peptides; Ang II infused in saline, NE and PHE in 0.2% ascorbic acid.

4944 Cervenka, L., Maly, J., Karasova, L., Simova, M., Vitko, S., Hellerova, S., Heller, J., El Dahr, S.S. Angiotensin II-induced hypertension in bradykinin B-2 receptor knockout mice. Hypertension 2001; 37(--):967-973. >>> Angiotensin II; Norepinephrine;; Saline;; IP;; mice;; 1002;; Controls received mp w/ vehicle; dose-response (p. 970); cardiovascular; angiotensin II and norepinephrine were infused into separate groups of animals..

4886 Weiss, D., Kools, J.J., Taylor, W.R. Angiotensin II-induced hypertension accelerates the development of atherosclerosis in ApoE-deficient mice. Circulation 2001; 103(--):448-454. >>> Angiotensin II; Norepinephrine;; Water; Sodium chloride; Acetic acid;; SC;; mice;; 1002;; Functionality of mp verified by plasma angiotensin levels; long-term study, pumps replaced 4 to 8 week study; vehicle solution was 0.15 M NaCl, .01 N acetic acid;.

4812 Ishizaka, N., Aizawa, T, Mori, I., Taguchi, J.-I, Yazaki, Y, Nagai, R, Ohno, M  Am. J. Physiol. Heart Circ. Physiol 2000; 279(--):H672-H678. >>> Angiotensin II; Norepinephrine; SC; IV (jugular vein); Rat; 2001; Controls received mp w/ vehicle; cardiovascular; antihypertensive; Angiotensin II infused SC; Norepinephrine infused IV;.

 

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“...opioid and nonopioid analgesics were continuously infused from subcutaneously implanted osmotic mini-pumps, a convenient modality of drug delivery that allows for drug delivery at constant rate for prolonged periods of time without experimenter intervention.” Bruins Slot et al., Pharmacology, Biochemistry and Behavior 2002;72:943-951.