References on the Administration of Norepinephrine Using ALZET^® Osmotic Pumps

Q0026 Owens,AP III, Subramanian,V., Moorleghen,J.J., Guo,Z.H., McNamara,C.A., Cassis,L.A., Daugherty,A. Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3. Circulation Research 2010; 106(-3-):611-U108. >>> Angiotensin II; norepinephrine; losartan; Saline; Mice; 4 weeks; 28 days; Controls received mp w/vehicle; peptides; cardiovascular; animal info (male, C57BL/6, AT1aR -/-, p47phox -/-, Id3 -/-); functionality of mp verified by systolic blood pressure.

P9494 Hongo,M., Ishizaka,N., Furuta,K., Yahagi,N., Saito,K., Sakurai,R., Matsuzaki,G., Koike,K., Nagai,R. Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart. European Journal of Pharmacology 2009; 604(-1-3-):87-92. >>> Angiotensin II, val5-; norepinephrine; SC; Rat; ; Peptides; animal info (male, Sprague Dawley, 250-300 g.).

P9553 Meier,H., Bullinger,J., Marx,G., Deten,A., Horn,L.C., Rassler,B., Zimmer,H.G., Briest,W. Crucial Role of Interleukin-6 in the Development of Norepinephrine-induced Left Ventricular Remodeling in Mice. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2009; 23(-4-6-):327-334. >>> Norepinephrine; SC; Mice; 1, 3 days; 4 hours; Controls received unfilled mp; animal info (IL-6 -/-, IL-6 +/+).

P9592 Mobine,H.R., Engelmayr,GC Jr, Moussazadeh,N., Anwar,T.R., Freed,L.E., Edelman,E.R. Encapsulated Pheochromocytoma Cells Secrete Potent Noncatecholamine Factors. Tissue Engineering Part A 2009; 15(-7-):1719-1728. >>> Norepinephrine; Saline; ascorbic acid; IP; Rat; 2004; 28 days; Controls received mp w/vehicle; animal info (female, Sprague-Dawley, 8 wks, 230g).

Q0531 Mobine,H.R., Baker,A.B., Wang,L.B., Wakimoto,H., Jacobsen,K.C., Seidman,C.E., Seidman,J.G., Edelman,E.R. Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors. Circulation-Heart Failure 2009; 2(-2-):121-128. >>> Norepinephrine; Ascorbic acid; saline; IP; Mice; rat; 2004; 1004; ; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 8 wks old, 250 g; female, black-6, 7 -8 wks old, 15-20 g).

P9252 Qin,Z.Y., Gongora,M.C., Ozumi,K., Itoh,S., Akram,K., Ushio-Fukai,M., Harrison,D.G., Fukai,T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; 14 days; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

P8582 Garg,P., Martin,C.F., Elms,S.C., Gordon,F.J., Wall,S.M., Garland,C.J., Sutliff,R.L., O'Neill,W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. American Journal of Physiology- Heart and Circulatory Physiology 2007; 292(-5-):H2100-H2105. >>> Norepinephrine; SC; Rat; 2001; 7 days; Functionality of mp verified by mean arterial blood pressure; cardiovascular; animal info (male, Sprague-Dawley, 360 grams).

P8451 Ideura,H., Hiromura,K., Hiramatsu,N., Shigehara,T., Takeuchi,S., Tomioka,M., Sakairi,T., Yamashita,S., Maeshima,A., Kaneko,Y., Kuroiwa,T., Kopp,J.B., Nojima,Y. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1214-F1221. >>> Angiotensin II; norepinephrine; SC; Mice (transgenic); 2004; 16 days; Functionality of mp verified by blood pressure; cardiovascular; peptides; animal info (FVB/N Podocin/rt TA tg, 7-8 wks old, 20-25g) nephrology.

P8523 Ko,E.A., Amiri,F., Pandey,N.R., Javeshghani,D., Leibovitz,E., Touyz,R.M., Schiffrin,E.L. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1789-H1795. >>> Norepinephrine; Mice; 2 weeks; Replacement therapy (nephrectomy); dose-response (fig 3); cardiovascular; animal info (3-4 months old, 20-35 g).

P8607 Ming,X.U., YanTing,Z., TianPao,H.A.O., Yao,S., ZhiZhen,L.U., QiDe,H.A.N., ShiQiang,W., YouYi,Z. Alpha 1-adrenergic receptors activate AMP-activated protein kinase in rat hearts. Acta Physiologica Sinica 2007; 59(-2-):175-182. >>> Norepinephrine; phenylephrine; Vitamin C; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, 330-440 grams, 12 weeks old).

P7990 Vongpatanasin,W., Thomas,G.D., Schwartz,R., Cassis,L.A., Osborne-Lawrence,S., Hahner,L., Gibson,L.L., Black,S., Samols,D., Shaul,P.W. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 2007; 115(-8-):1020-1028. >>> Angiotensin II; norepinephrine; SC; Mice; 2002; 14 days; Blood pressure taken; cardiovascular; peptides; animal info (CF1-CRP).

P7440 Ayabe,N., Babaev,V.R., Tang,Y.W., Tanizawa,T., Fogo,A.B., Linton,M.F., Ichikawaa,I., Fazio,S., Kon,V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 2006; 184(-2-):312-321. >>> Angiotensin II; norepinephrine; SC; Mice; 1002; 2 weeks; Controls received mp w/ saline; dose-response (fig.1); stress/adverse reaction: (see pg. 313) 2 animals of 105 had mp extrusion; cardiovascular; peptides; animal info (female, C57BL/6, 8 weeks old).

P8057 Eagleton,M.J., Ballard,N., Lynch,E., Srivastava,S.D., Upchurch,GR Jr, Stanley,J.C. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. Journal of Surgical Research 2006; 135(-2-):345-351. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 2004; 7, 14, 21, 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6J wt or ApoE -/-, male, 8-6 months old).

P8897 Ishizaka,N., Matsuzaki,G., Saito,K., Noiri,E., Mori,I., Nagai,R. Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat. LABORATORY INVESTIGATION 2006; 86(-12-):1285-1292. >>> Angiotensin II, val5-; norepinephrine; SC; Rat; 2001; 7 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 250-300 g.); nephrology.

P7800 Palm,D., Lang,K., Niggemann,B., Drell,T.L., Masur,K., Zaenker,K.S., Entschladen,F. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by betablockers. International Journal of Cancer 2006; 118(-11-):2744-2749. >>> Norepinephrine; propranolol; Saline, physiological; ascorbic acid; SC; Mice (nude); 1002; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; half-life (pg. 2745) short, quickly metabolized; cancer (prostate carcinoma); animal info (female, BALB/C nude, athymic, 6 wk. old, 15g.).

P8061 Wolf,G., Bohlender,J., Bondeva,T., Roger,T., Thaiss,F., Wenzell,U.O. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Journal of the American Society of Nephrology 2006; 17(-6-):1585-1593. >>> Angiotensin II; norepinephrine; IP; Rat; 2002; 7 days; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 200g.); nephrology.

P8395 Zhao,W.Y., Swanson,S.A., Ye,J.F., Li,X.L., Shelton,J.M., Zhang,W.G., Thomas,G.D. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 2006; 48(-4-):637-643. >>> Angiotensin II; norepinephrine; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle, or sham surgery; cardiovascular; peptides; animal info (Sprague-Dawley, 200-300g., unilateral renal artery stenosis).

P7583 Chen,Y., Currie,R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; 3, 7 days; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

P7599 Ishizaka,N., Saito,K., Mori,I., Matsuzaki,G., Ohno,M., Nagai,R. Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II - Infused rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-11-):2282-2288. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 2001; 4 weeks; 7 days; Controls received no treatment; dose-response (fig. 1); cardiovascular; peptides; animal info (male, Sprague-Dawley).

P7530 Saito,K., Ishizaka,N., Hara,M., Matsuzaki,G., Sata,M., Mori,I., Ohno,M., Nagai,R. Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II. Hypertension 2005; 46(-5-):1180-1185. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 2001; 7 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-300 g); lipotoxicity.

P7739 Saito,K., Ishizaka,N., Aizawa,T., Sata,M., Iso-o,N, Noiri,E., Mori,I., Ohno,M., Nagai,R. Iron chelation and a free radical scavenger suppress angiotensin II- induced upregulation of TGF-beta 1 in the heart. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-4-):H1836-H1843. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 7 days; Controls received no treatment; cardiovascular; animal info (male, Sprague-Dawley).

P6492 Chen,Y., Ross,B.M., Currie,R.W. Heat shock treatment protects against angiotensin II-induced hypertension and inflammation in aorta. CELL STRESS&CHAPERONES 2004; 9(-1-):99-107. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (vena cava); Rat; 2001; 2002; 2ML2; 1,3,5,7,11,14 days; Controls received empty mp for 7 days; functionality of mp verified by SBP; cardiovascular; peptides.

P7080 Li,Z.P., Oben,J.A., Yang,S.Q., Lin,H.Z., Stafford,E.A., Soloski,M.J., Thomas,S.A., Diehl,A.M. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 2004; 40(-2-):434-441. >>> Norepinephrine; Saline, pyrogen-free; Mice; 3,4 weeks; Controls received mp w/ vehicle.

P6465 Oben,J.A., Roskams,T., Yang,S., Lin,H., Sinelli,N., Torbenson,M., Smedh,U., Moran,T.H., Li,Z., Huang,J., Thomas,S.A., Diehl,A.M. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 2004; 53(-3-):438-445. >>> Isoprenaline; norepinephrine; SC; Mice; 4 weeks; Controls received mp w/ vehicle.

P5728 Briest,W., Holzl,A., Rassler,B., Deten,A., Baba,H.A., Zimmer,H.G. Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts. Cardiovascular Research 2003; 57(-2-):379-387. >>> Norepinephrine; Saline; Ascorbic Acid; IV (jugular); Rat; 14 days; Controls received mp w/ vehicle; cardiovascular; Norepinephrine is also called Noradrenalin; ascorbic acid added to vehicle solution to prevent oxidation.

P5834 Caprile,T., Hein,S., Rodriguez,S., Montecinos,H., Rodriguez,E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. MOLECULAR BRAIN RESEARCH 2003; 110(-2-):177-192. >>> Serotonin, binoxaiate; Norepinephrine; serotonin trifluoroacetate; Serotonin creatinin sulfate; L-DOPA; CSF, artificial; radio-isotopes; 3H tracer; CSF/CNS; Rat; 2001; 7 days.

P5663 Festuccia,W.T.L., Guerra-Sa,R., Kawashita,N.H., Garofalo,M.A.R., Evangelista,E.A., Rodrigues,V., Kettelhut,I.C., Migliorini,R.H. Expression of glycerokinase in brown adipose tissue is stimulated by the sympathetic nervous system. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-6-):R1536-R1541. >>> Norepinephrine; dobutamine; isoproterenol; Saline; sodium metabisulfite; SC; Rat; 2002; 3 days; 6, 12, 24, 72 hours; Controls received mp w/ vehicle; the norepinephrine vehicle solution contained sodium metabisulfite as an antioxidant; the b-adrenergic agonists (isoproterenol, dobutamine, and CL316243) were dissolved in saline and infused over 3 days..

P6079 Li,P., Li,J., Feng,X., Li,Z., Hou,R., Han,C., Zhang,Y. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. CELLULAR AND MOLECULAR LIFE SCIENCES 2003; 60(-10-):2200-2209. >>> Norepinephrine; Ascorbic acid; IV (jugular); Rat; 2002; 7 days; Functionality of mp verified by liquid chromatography; cardiovascular.

P6051 Mardon,K., Montague,O., Elbaz,N., Malek,Z., Syrota,A., Dubois-Rande,J.L., Meignan,M., Merlet,P. Uptake-1 carrier downregulates in parallel with theβ-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: Implications for cardiac neuroimaging in human cardiomyopathies. Journal of Nuclear Medicine 2003; 44(-9-):1459-1466. >>> Norepinephrine; Saline; IV (jugular); Rat; 2001; 5 days; Controls received mp w/ vehicle; cardiovascular; silastic catheter used.

P6087 Saito,K., Ishizaka,N., Mitani,H., Ohno,M., Nagai,R. Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Letters 2003; 551(-1-3-):58-62. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; 1 week; Peptides.

P6408 Van Landeghem,F.K.H., Schreiber,S., Unterberg,A.W., Von Deimling,A., Stover,J.F. Differential concentration-dependent effects of prolonged norepinephrine infusion on intraparenchymal hemorrhage and cortical contusion in brain-injured rats. Journal of Neurotrauma 2003; 20(-12-):1327-1337. >>> Norepinephrine; Saline; IV; Rat; 2001; 44 hours; Controls received mp w/ vehicle; blood pressure taken; dose-response (p. 1329); brain injury.

P5221 Aizawa,T., Ishizaka,N., Usui,S., Ohashi,N., Ohno,M., Nagai,R. Angiotensin II and catecholamines increase plasma levels of 8-epi- prostaglandin F(2alpha) with different pressor dependencies in rats. Hypertension 2002; 39(-1-):149-154. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; 2001; up to 7 days; Dose-response (p. 151); cardiovascular; peptides.

P5396 Bonnefont-Rousselot,D., Mahmoudi,A., Mougenot,N., Varoquaux,O., Le Nahour,G., Fouret,P., Lechat,P. Catecholamine effects on cardiac remodelling, oxidative stress and fibrosis in experimental heart failure. REDOX REPORT 2002; 7(-3-):145-151. >>> Norepinephrine; Saline; SC; Rat; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by norepinephrine plasma levels (p.148); cardiovascular; also called noradrenalin (a catecholamine).

P5473 Erami,C., Zhang,H., Ho,J.G., French,D.M., Faber,J.E. Alpha 1-adrenoceptor stimulation directly induces growth of vascular wall in vivo. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-4-):H1577-H1587. >>> Norepinephrine; benoxathian; prazosin; KMD-3213; AH11110A; BMY-7378; propranolol; RX-821002; Ringer's, lactated; ascorbate; Perivascular; Rat; 2ML2; 14, 28 days; Tissue perfusion (left carotid wall); pumps replaced after 14 days for prazosin; catheter constructed from thin walled vinyl tubing and fenestrated at end placed near vessel; norepinephrine is a catecholamine; propranolol is a beta adrenoceptor antagonist; all other agents are antagonists alpha antagonists.

P5574 Golden,K.L., Ren,J., Dean,A., Marsh,J.D. Norepinephrine regulates the in vivo expression of the L-type calcium channel. MOLECULAR AND CELLULAR BIOCHEMISTRY 2002; 236(-1-2-):107-114. >>> Isoproterenol; Norepinephrine; Phenylephrine; HCl; SC; rat; 3, 7 days; controls received mp with vehicle; alpha&beta adrenergic agonist.

P5447 Ishizaka,N., Saito,K., Mitani,H., Yamazaki,I., Sata,M., Usui,S., Mori,I., Ohno,M., Nagai,R. Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. Circulation 2002; 106(-14-):1840-1846. >>> Angiotensin II; hydralazine; losartan; norepinephrine; SC; Rat; 2001; 7 days; Antihypertensive.

P5223 Ishizaka,N., Aizawa,T., Ohno,M., Usui,Si S., Mori,I., Tang,S.S., Ingelfinger,J.R., Kimura,S., Nagai,R. Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. Hypertension 2002/1; 39(-1-):122-128. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; 7 days; Peptides.

P5230 Mitani,H., Ishizaka,N., Aizawa,T., Ohno,M., Usui,S., Suzuki,T., Amaki,T., Mori,I., Nakamura,Y., Sato,M., Nangaku,M., Hirata,Y., Nagai,R. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002/4; 39(-4-):838-843. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; 7 and 14 days; Peptides.

P5159 Moser,L., Faulhaber,J., Wiesner,R.J., Ehmke,H. Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 282(--):R1389-R1394. >>> Angiotensin II; Norepinephrine; SC; rat; 2001; 7 days; cardiovascular.

P5067 Vecchione,C., Fratta,L., Rizzoni,D., Notte,A., Poulet,R., Porteri,E., Frati,G., Guelfi,D., Trimarco,V., Mulvany,M.J., Agabiti-Rosei,E., Trimarco,B., Cotecchia,S., Lembo,G. Cardiovascular influences of alpha 1b-adrenergic receptor defect in mice. Circulation 2002/4/9; 105(-14-):1700-1707. >>> Angiotensin II; Norepinephrine; Phenylephrine; Saline; Ascorbic acid; SC; mice (transgenic); 2004; 18 days; controls received mp w/ vehicle; cardiovascular; peptides; Ang II infused in saline, NE and PHE in 0.2% ascorbic acid.

P5068 Wenzel,U.O., Thaiss,F., Helmchen,U., Stahl,R.A.K., Wolf,G. Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis. Kidney International 2002; 61(--):1020-1029. >>> Angiotensin II; Norepinephrine; SC; rat; 2002; 6-10 days; peptides; all animals received either Ang II or NE.

P5192 Briest,W., Holzl,A., Rassler,B., Deten,A., Leicht,M., Baba,H.A., Zimmer,H.G. Cardiac remodeling after long term norepinephrine treatment in rats. Cardiovascular Research 2001; 52(--):265-273. >>> Norepinephrine; nisoldipin; Saline; ascorbic acid; ethanol; IP; IV (jugular); Rat; 3 or 14 days; Controls received mp w/ vehicle; comparison of infusion pump vs. mp; cardiovascular; Norepinephrine was infused IV for 14 days in saline w/ 0.01% ascorbic acid; nisoldipin, a calcium channel blocker, was delivered IP for 3 days in absolute ethanol.

P4832 Cervenka,L., Maly,J., Karasova,L., Simova,M., Vitko,S., Hellerova,S., Heller,J., El Dahr,S.S. Angiotensin II-induced hypertension in bradykinin B-2 receptor knockout mice. Hypertension 2001; 37(--):967-973. >>> Angiotensin II; Norepinephrine;; Saline;; IP;; mice;; 1002;; 13 days;; Controls received mp w/ vehicle; dose-response (p. 970); cardiovascular; angiotensin II and norepinephrine were infused into separate groups of animals..

P8593 Dao,H.H., Martens,F.M., Lariviere,R., Yamaguchi,N., Cernacek,P., De Champlain,J., Moreau,P. Transient involvement of endothelin in hypertrophic remodeling of small arteries. J Hypertens 2001; 19(-10-):1801-1812. >>> Norepinephrine; angiotensin II; SC; Rat; 2002; 2004; 3,7,14,28 days; Functionality of mp verified by plasma NE levels and blood pressure; cardiovascular; peptides; animal info (Sprague-Dawley, 175-200 grams).

P4775 Weiss,D., Kools,J.J., Taylor,W.R. Angiotensin II-induced hypertension accelerates the development of atherosclerosis in ApoE-deficient mice. Circulation 2001; 103(--):448-454. >>> Angiotensin II; Norepinephrine;; Water; Sodium chloride; Acetic acid;; SC;; mice;; 1002;; 4 or 8 weeks; Functionality of mp verified by plasma angiotensin levels; long-term study, pumps replaced 4 to 8 week study; vehicle solution was 0.15 M NaCl, .01 N acetic acid;.

P4702 Ishizaka,N., Aizawa,T, Mori,I., Taguchi,J.-I, Yazaki,Y, Nagai,R, Ohno,M  Am.J.Physiol.Heart Circ.Physiol. 2000; 279(--):H672-H678. >>> Angiotensin II; Norepinephrine; SC; IV (jugular vein); Rat; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; antihypertensive; Angiotensin II infused SC; Norepinephrine infused IV;.

P3870 Wang,P., Tait,S.T., Chaudry,I.H. Sustained elevation of norepinephrine depresses hepatocellular function. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2000; 1535(--):36-44. >>> Norepinephrine bitartrate; Saline; IP; rat; 2ML1; 24 hours; controls received mp w/ vehicle; functionality of mp verified by plasma norepinephrine levels..

P5113 Fukai,T, Siegfried,M.R., Ushio-Fukai,M, Griendling,K.K., Harrison,D.G. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circulation Research 1999; 85(--):23-28. >>> Angiotensin II, [Val 5]; Norepinephrine; Losartan; SC; mice; 2002; 7 days; controls received empty pump or sham surgery; cardiovascular; peptides; antihypertensive; some animals received 2 pumps for treatment with both Ang II and Losartan simultaneously; losartan is an AT1 receptor antagonist.

P4071 Sun,X., Ng,Y.-C. Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart. Cardiovasc.Res. 1998; 37(--):202-209. >>> Norepinephrine bitartrate; Saline; Ascorbic acid; SC; rat; 2002; 3,6,14 days; controls received mp w/vehicle; cardiovascular; antihypertensive.

P4068 Zhou,Y.-G., Wang,Z.-G., Zhu,P.-F., Xiong,R.-P. Role of G proteins in the cardiovascular adrenergic desensitization of rats. Chinese J.Pharmacol.Toxicol. 1998; 12(-2-):117-122. >>> Norepinephrine; SC; rat; 2001; 3,6 days; article written in Chinese with English abstract; cardiovascular.

P4124 Al-Arabi,A., Andrews,J.F. Synergistic action by neuropeptide y (NPY) and norepinephrine (NE) on food intake, metabolic rate, and brown adipose tissue (bat) causes remarkable weight loss in the obese (fa/fa) Zucker rat. Biomed.Sci.Instrum. 1997; 33(--):216-225. >>> Neuropeptide Y; Norepinephrine; SC; rat; 2002; 14 days; controls received mp w/vehicle; agents infused alone or in combination; peptides.

P6662 Capers,Q, Alexander,W, Lou,P., de Leon,H., Wilcox,J.N., Ishizaka,N, Howard,A.B, Taylor,W.R. Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats. Hypertension 1997; 30(--):1397-1402. >>> Angiotensin II; norepinephrine; Sodium chloride; acetic acid; SC; IV (jugular); Rat; 2002; 7 days; Controls received mp w/ vehicle or sham operation; functionality of mp verified by blood pressure measurements.

P3824 Chi,M.S., Vander Tuig,J.G., Chi,C.H., Norman,A., Chapman,L., Blanks,T. Effects of norepinephrine infusion and exercise on blood pressure in rats. P.S.E.B.M. 1997; 215(--):174-178. >>> Norepinephrine bitartrate; Saline; SC; rat; 14 days; controls received mp w/saline; cardiovascular.

P4611 Du,Y, Qiu,J, Nelson,S.H, Wang,D.H. Regulation of type 1 ANG II receptor in vascular tissue: role of a1-adrenoreceptor.. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.42) 1997; 273(--):R1224-R1229. >>> Norepinephrine; Prazosin;; Saline, physiological; DMSO;; SC;; rat;; 2002; 2ML2;; 2 weeks;; controls received mp w/vehicle; antihypertensive; cardiovascular;.

P3796 Hamada,H., Hakamata,N., Ohsuzu,F., Nakamura,H. Age-related effects of norepinephrine on rat ventricular hypertrophy. Jpn.Heart J. 1997; 38(-3-):433-443. >>> Norepinephrine HCl; Norepinephrine bitartrate; Bunazosin; Bisoprolol; SC; rat; 2002; 7, 14 days; controls received mp w/saline or norepinephrine; dose-response; antihypertensive; cardiovascular; 2 pumps implanted in each animal.

P6324 Ishizaka,N, de Leon,H., Laursen,J.B., Fukui,T., Wilcox,J.N., De Keulenaer,G., Griendling,K.K., Alexander,W. Angiotensin II-Induced Hypertension Increases Heme Oxygenase-1 Expression in Rat Aorta. Circulation 1997; 96(--):1923-1929. >>> Angiotensin II; norepinephrine; Sodium chloride; acetic acid; SC; IV (vena cava); Rat; 2001; 1,3,5,7, days; Cardiovascular; Ang II via SC, NE via IV administration.

P4612 Lantelme,P, Lo,M, Luttenauer,L, Sassard,J. Pivotal role of the renin-angiotensin system in Lyon hyertensive rats.. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.42) 1997; 273(--):R1793-R1799. >>> Angiotensin II; Norepinephrine; IV (jugular); Rat; 2ML4; 4 weeks; Stability of norepinephrine verified at the end of the experiment by testing the pressure effect of the residual solution; peptides; cardiovascular;.

P3864 Seasholtz,T.M., Gurdal,H., Wang,H.-Y., Johnson,M.D., Friedman,E. Desensitization of norepinephrine receptor function is associated with G protein uncoupling in the rat aorta. Am.J.Physiol. 1997; 273(-42-):H279-H285. >>> Norepinephrine; Ascorbic acid; NaCl; SC; rat; 2001; 6 days; cardiovascular.

P3584 De Blois,D., Schwartz,S.M., van Kleef,E.M., Su,J.E., Griffin,K.A., Bidani,A.K., Daemen,M.J.A.P., Lombardi,M.J.A.P. Chronic a(1)-adrenoreceptor stimulation increases DNA synthesis in rat arterial wall. Arterioscler.Thromb.Vasc.Biol. 1996; 16(--):1122-1129. >>> Phenylephrine; Norepinephrine; Uridine, bromodeoxy-;; Ringer's solution, lactated; Ascorbate;; SC;; rat;; 2002;; 2 weeks;; 2 pumps implanted simultaneously; cell proliferation;.

P4199 Kaddoura,S., Firth,J.D., Boheler,K.R., Sugden,P.H., Poole-Wilson,P.A. Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Circulation 1996; 93(--):2068-2079. >>> Norepinephrine bitartrate; Saline; Ascorbate; SC; rat; 2001; 1,2,3,5,7 days; controls received mp w/vehicle; cardiovascular.

P3647 Laycock,S.K., Kane,K.A., McMurray,J., Parratt,J.R. Captopril and norepinephrine-induced hypertrophy and haemodynamics in rats. J.Cardiovasc.Pharmacol. 1996; 27(--):667-672. >>> Norepinephrine; Captopril; Ascorbic acid; Saline; SC; rat; 2ML4; 28 days; controls received vehicle infusion; antihypertensive; multiple pumps per animal (1 or 2).

P2822 Granneman,J.G  Endocrinology 1995; 136(-5-):2007-2012. >>> Norepinephrine; Isoproterenol; Phenylephrine; Ascorbic acid; rat; 2001; 4 days; controls received mp with vehicle; isoproterenol and phenylephrine infused separately and together.

P4063 Harris,T.J., Waltman,T.J., Carter,S.M., Maisel,A.S. Effect of prolonged catecholamine infusion on immunoregulatory function: implications in congestive heart failure. J.Am.Coll.Cardiol. 1995; 26(-1-):102-109. >>> Epinephrine; Norepinephrine; Propranolol; HCl; Ascorbic acid; SC; rat; 4 weeks; controls received mp w/vehicle; immunology, antihypertensive; cardiovascular.

P3303 Laycock,S.K., McMurray,J., Kane,K.A., Parratt,J.R. Effects of chronic norepinephrine administration on cardiac function in rats. J.Cardiovasc.Pharmacol. 1995; 26(--):584-589. >>> Norepinephrine; Saline; Ascorbic acid; SC; rat; 2ML4; 10-28 days; controls received mp w/acid saline.

P2813 Nishino,K., Kikuchi,K., Ohyu,H., Kowada,M. Chronic intraventricular norepinephrine and delayed neuronal death in the hippocampus. J.Clin.Neuroscience 1995; 2(-2-):152-155. >>> Norepinephrine; Ascorbic acid; CSF/CNS; gerbil; 2001; 14 days; brain tissue distribution; pump placed intraperitoneally.

P2844 Tsukazaki,K., Nikami,H., Shimizu,Y., Kawada,T., Yoshida,T., Saito,M. Chronic administration of B-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. J.Biochem 1995; 117(--):96-100. >>> Norepinephrine; Isoproterenol; Phenylephrine HCl; Ascorbic acid; SC; rat; 10 days; controls received mp with vehicles; agents are adrenergic agonists.

P3079 Zhou,Y., Friedman,E., Roberts,J., Johnson,M.D. Modulation of aortic and cardiac G protein alpha subunits and their mRNAs during norepinephrine infusion in rats. J.Vasc.Res. 1995; 32(--):16-23. >>> Norepinephrine; Saline; Ascorbic acid; SC; rat; 2001; 3, 6 days; controls received mp with vehicle.

P3243 Liu,X., Perusse,F., Bukowiecki,L.J. Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.35) 1994; 266(--):R914-R920. >>> Norepinephrine; Water, distilled; Sodium metabisulfite; SC; rat; 1007D; 4 days; controls received mp with vehicle.

P4074 Butterfield,M.C., Chess-Williams,R. Potentiation of a-adrenoceptor-mediated responses following chronic b-adrenoceptor stimulation in the rat heart. Br.J.Pharmacol. 1993; 108(--):658-662. >>> Norepinephrine; Isoproterenol; Saline; Ascorbic acid; SC; rat; 2001; 3 days; controls received mp w/vehicle.

P2687 Carpene,C., Galitzky,J., Collon,P., Esclapez,F., Dauzats,M., Lafontan,M. Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J.Pharmacol.Exp.Ther. 1993; 265(-1-):237-247. >>> Norepinephrine; SC; hamster; guinea-pig; 2001; no duration posted; controls received sham operations; comparison of ip injections.

P3192 Himura,Y., Felten,S.Y., Kashiki,M., Lewandowski,T.J., Delahanty,J.M., Liang,C.-S. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation 1993; 88(--):1299-1309. >>> Norepinephrine; SC; dog; 2ML4; 8 weeks; controls received mp with saline; long-term study, pumps replaced after 3-4 weeks.

P2612 McCorkle,F.M., Taylor Jr,R.L. Biogenic amines regulate avian immunity. Poult.Sci. 1993; 72(--):1285-1288. >>> Epinephrine; Norepinephrine;; Saline; SC; bird (chicken); 2001; 24,48 or 72 hours; controls received mp w/ vehicle; immunology.

P2103 Brown,L., Sernia,C., Newling,R., Fletcher,C. Cardiac responses after norepinephrine-induced ventricular hypertrophy in rats. J.Cardiovasc.Pharmacol. 1992; 20(--):316-323. >>> Norepinephrine HCl; Ascorbic acid; Saline; SC; rat; 2002; 14 days; no comment posted.

P2049 Brown,L.A., Harding,S.E. The effect of pertussis toxin on B-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. Br.J.Pharmacol. 1992; 106(--):115-122. >>> Norepinephrine HCl; Ascorbate; Saline; SC; guinea-pig; 2002; 7 days; toxicology.

P2035 Stewart,J.M., Patel,M.B., Wang,J., Ochoa,M., Gewitz,M., Loud,A.V., Anversa,P., Hintze,T.H. Chronic elevation of norepinephrine in conscious dogs produces hypertrophy with no loss of LV reserve. Am.J.Physiol. 1992; 262(-31-):H331-H339. >>> Norepinephrine; SC; dog; 2ML4; 28 days; an additional pump was implanted sc on day 10 to maintain plasma levels of norepinephrine p. 332.

P2451 Yoshida,K., Yasujima,M., Kohzuki,M., Kanazawa,M., Yoshinaga,K., Abe,K. Endothelin-l augments pressor response to angiotensin ll infusion in rats. Hypertension 1992; 20(-3-):292-297. >>> Norepinephrine; Angiotensin II; Endothelin; Acetic acid; Saline; IP; IV (jugular); rat; 6 days; controls received mp w/ vehicle; functionality of mp verified upon removal; peptides.

P2150 Fujimura,A., Ohashi,K.-I., Ebihara,A. Chronopharmacological study of furosemide; (IX) influence of continuous norepinephrine infusion. Life Sci. 1991; 50(--):449-455. >>> Norepinephrine; Ascorbic acid; Saline; SC; rat; 2ML2; 11 days; controls received mp with vehicle.

P2004 Johnson,M.D., Wang,H.-Y., Ciechanowski,D., Friedman,E. Reduced G protein function in desensitized rat aorta. J.Pharmacol.Exp.Ther. 1991; 259(-1-):255-259. >>> Norepinephrine; Ascorbic acid; Saline; SC; rat; 2001; 6 days; no comment posted.

P2038 Kuroshima,A., Ohno,T. Cold- and noradrenaline-induced changes in ganglioside GM3 levels of rat brown adipose tissue. J.Therm.Biol. 1991; 16(-1-):37-39. >>> Norepinephrine bitartrate; Ascorbic acid; Tiron; rat; 2002; 2 weeks; no comment posted.

P2409 Patel,M.B., Stewart,J.M., Loud,A.V., Anversa,P., Wang,J., Fiegel,L., Hintze,T.H. Altered function and structure of the heart in dogs with chronic elevation in plasma norepinephrine. Circulation 1991; 84(-5-):2091-2100. >>> Norepinephrine; SC; dog; 2ML4; 28 days; no comment posted.

P1727 Albino-Teixeira,A., Azevedo,I., Branco,D., Osswald,W. Purine agonists prevent trophic changes caused by sympathetic denervation. Eur.J.Pharmacol. 1990; 179(--):141-149. >>> Adenosine; Adenosine, N-ethylcarboxamido-; Inosine; Norepinephrine; IV (saphenous); dog; 2ML1; no duration posted; functionality of mp verified by inspecting catheter for clots, observing collapsed pump reservoir, and measuring residual drug solution.

P1801 Eickenburg,D.C. Effects of chronic norepinephrine administration on sympathetic neurotransmission in the isolated perfused rat kidney. J.Pharmacol.Exp.Ther. 1990; 255(-3-):1053-1059. >>> Epinephrine; Norepinephrine; Ascorbic acid; Saline; SC; rat; 6 days; no comment posted.

P3202 Jones,S.M., Hunt,N.A., Del Monte,F., Harding,S.E. Contraction of cardiac myocytes from noradrenaline-treated rats response to isoprenaline, forskolin and dibutyryl cAMP. Eur.J.Pharmacol. 1990; 191(--):129-140. >>> Norepinephrine bitartrate; Ascorbate; SC; rat; 2001; 2002; 7-14 days; controls received sham operation.

P1577 Yakubu,M.A., Deighton,N.M., Hamilton,C.A., Reid,J.L. Differences in the regulation of [3H]idazoxan and [3H]yohimbine binding sites in the rabbit. Eur.J.Pharmacol. 1990; 176(--):305-311. >>> Amitriptyline; Idazoxan; Norepinephrine; Saline; IP; IV (femoral); rabbit; 5, 10, 21 days; not clear that amitriptyline delivered by pumps.

P2040 Yasujima,M., Abe,K., Tanno,M., Kohzuki,M., Kanazawa,M., Yoshida,K., Omata,K., Sato,M., Takeuchi,K., Hiwatari,M., Sato,T., Yoshinaga,K. Effects of digoxin on blood pressure responses to norepinephrine, angiotensin II and vasopressin in conscious rats. Tohoku J.Exp.Med. 1990; 162(--):203-212. >>> Angiotensin II; Norepinephrine bitartrate; Vasopressin; Acetic acid; Ascorbic acid; Glutathione; IP; rat; 2001; 6 days; peptides.