References on the Administration of Nonsteroidal Anti-inflammatory Drugs Using ALZET® Osmotic Pumps

1. Acetylsalicylic Acid

P8555 Adamek,A., Hu,K., Bayer,B., Wagner,H., Ertl,G., Bauersachs,J., Frantz,S. High dose aspirin and left ventricular remodeling after myocardial infarction. Basic Research In Cardiology 2007; 102(-4-):334-340. >>> Acetylsalicylic acid, lysine; Saline; SC; Mice; 2002; 4 weeks; Controls received mp w/ placebo; functionality of mp verified by serum salicylate concentrations; pumps replaced after 2 weeks; cardiovascular; ischemia (cardiac); animal info (female, C57BL/6, 8-12 weeks old, 20-25 grams); MI induced by coronary artery ligation.

P4829 Yuan,M, Konstantopoulos,N, Lee,J, Hansen,L, Li,Z.-W, Karin,M, Shoelson,S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkb. Science 2001; 293(--):1673-1677. >>> Acetylsalicylic acid; salicylate, sodium; SC; Rat; mice; 2002; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; 2ML2 used in rats, 2002 used in mice; acetylsalicylic acid also called aspirin: dose was 120 mg/kg/day; diabetes (type II).

P0455 Oshima,T., McCluskey,E.R., Honda,A., Needleman,P. Pharmacological manipulation of canine cyclooxygenase and thromboxane synthetase in vivo: differential renal and platelet recovery rates. J.Pharmacol.Exp.Ther. 1984; 229(-2-):598-602. >>> Acetylsalicylic acid; DMSO; Saline; IV (superficial cervical vein); dog; 2ML1; 3 days; pumps primed for 4 hrs. before implant; used prefilled catheter in vein; greater solubility of ASA in DMSO allowed greater concentration in smaller total volume.

top of page

2. Diclofenac

P5994 Murase,T., Tian,Y., Fang,X.Y., Verbalis,J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; 5 days; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

P3383 Risto,O., Wahlstrom,O., Abdiu,A. The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats. Int.Orthopaedics (SICOT) 1995; 19(--):392-395. >>> Diclofenac; NaCl; bone; rat; 2001;

top of page

3. Flurbiprofen

Q0222 Campanella,C., Jamali,F. Influence of prolonged exposure of a short half life non-steroidal anti-inflammatory drugs on gastrointestinal safety. INFLAMMOPHARMACOLOGY 2009; 17(-4-):205-210. >>> Flurbiprofen; PEG 400; IP; Rat; 2002; 7 days; Comparison of IP injections vs. mp; stability verified in vitro test for 14 days; animal info (male, Sprague Dawley, adult, 300-350 g.); "There was no significant difference between the two i.p. groups in the post-mortem plasma R or S-flurbiprofen concentration or in the percent of the dose excreted as glucoronidated flurbiprofen in urine on days 1 and 7" pg 207.

P7625 Peretto,I., Radaelli,S., Parini,C., Zandi,M., Raveglia,L.F., Dondio,G., Fontanella,L., Misiano,P., Bigogno,C., Rizzi,A., Riccardi,B., Biscaioli,M., Marchetti,S., Puccini,P., Catinella,S., Rondelli,I., Cenacchi,V., Bolzoni,P.T., Caruso,P., Villetti,G., Facchinetti,F., Del Giudice,E., Moretto,N., Imbimbo,B.P. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors beta-amyloid (1-42) secretion. Journal of Medicinal Chemistry 2005; 48(-18-):5705-5720. >>> Flurbiprofen analogues; flurbiprofen; SC; Rat; 2001; 4-7 days; Dose-response; neurodegenerative (Alzheimer's disease); cassette dosing technology: 2-6 different analog compounds administered simultaneously to one animal.

P1533 Offenbacher,S., Odle,B.M., Braswell,L.D., Johnson,H.G., Hall,C.M., McClure,H., Orkin,J.L., Strobert,E.A., Green,M.D. Changes in cyclooxygenase metabolites in experimental periodontitis in macaca mulatta. J.Periodontal Res. 1989; 24(--):63-74. >>> Flurbiprofen; SC; monkey; 2ML2; 2ML4; 6, 12 months; controls received no drugs or sham pumps; multiple pumps per animal (2) (simultaneously); pumps replaced every 2 weeks or monthly; long-term study; one animal removed from study due to a 'secondary infection caused by a cage-pressure abrasion at the site of the s.c..

P1208 Offenbacher,S., Braswell,L.D., Loos,A.S., Johnson,H.G., Hall,C.M., McClure,H., Orkin,J.L., Strobert,E.A., Green,M.D., Odle,B.M. Effects of flurbiprofen on the progression of periodontitis in macaca mulatta. J.Periodontal Res. 1987; 22(-6-):473-481. >>> Flurbiprofen; Tris buffer; SC; monkey; 2ML2; 2ML4; 6 months; controls received mp w/ tris buffer; dose-response (table); 2 doses of agent infused; high dosage group received 2 pumps (2ML2); pumps replaced every 4 weeks for 2ML4, 2 weeks for 2ML2; long-term study.

top of page

4. Ibuprofen

Q4741 Sharp,K.G., Yee,K.M., Stiles,T.L., Aguilar,R.M., Steward,O. A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. Experimental Neurology 2013; 248(--):321-337. >>> Ibuprofen; Saline; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 9-10 weeks old); spinal cord injury; post op. care (bladders expressed BID); behavioral testing (hindlimb locomotor function; gridwalk task, footprint analysis, girdle test, plantar von frey); immunology; pumps primed primed for 16h in 37C saline;.

Q4703 Benadiba,M., Costa,I.D., Santos,R.L.S.R., Serachi,F.O., Silva,D.D., Colquhoun,A., Colquhoun,A. Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru(2)Cl(Ibp)(4)], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo 1993. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 2014; 19(--):1025-1035. >>> Diruthenium-ibuprofen; Ethanol; CSF, artificial; CSF/CNS (intratumoral); Rat; 2002; 14 days; Animal info (female, Wistar, 250-350g); ALZET brain infusion kit used; 15% ethanol used; comparison of injection vs mp; cancer (glioma); tissue perfusion (intratumoral, glioma);â·Using the orthotopic C6 model the effects of either chronic 14-day treatment by intra-peritoneal injection of chronic 14-day intra-tumour infusion by an Alzet osmotic pump attached to a brain infusion cannula were tested. Tumour growth was reduced by both routes of administration with the osmotic pump appearing to be the less harmful route in terms of haematological responses.âpg 1033; Diruthenium-Ibuprofen aka RuIbp;.

Q3526 Jurk,D., Wilson,C., Passos,J.F., Oakley,F., Correia-Melo,C., Greaves,L., Saretzki,G., Fox,C., Lawless,C., Anderson,R., Hewitt,G., Pender,S.L.F., Fullard,N., Nelson,G., Mann,J., van de Sluis,B., Mann,D.A., von Zglinicki,T., von Zglinicki,T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications 2014; 5(--):U235-U248. >>> Ibuprofen; PEG; DMSO; SC; Mice; 2004; 8 weeks; Animal info (male, nfkb1 -/-, 24 weeks old); pumps replaced every 28 days; 50% DMSO used; 50% PEG used; behavioral testing (tightrope test); used 7mm wound clips;.

Q1221 Madura,T., Tomita,K., Terenghi,G. Ibuprofen improves functional outcome after axotomy and immediate repair in the peripheral nervous system. Journal of Plastic Reconstructive and Aesthetic Surgery 2011; 64(-12-):1641-1646. >>> Ibuprofen; PBS; SC; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; animal info (female, Wistar, 200 g); stress/adverse reaction: "pressure necrosis" (see pg. 1643).

Q0207 Van Dam,D., Coen,K., De Deyn,P.P. Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. JOURNAL OF PSYCHOPHARMACOLOGY 2010; 24(-3-):383-388. >>> Ibuprofen; PEG 300; water, ultrapure; SC; Mice; 2004; 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced after 4 weeks; animal info (6 wks old, male, APP23); neurodegenerative (Alzheimer's Disease).

P9697 Wang,X.X., Budel,S., Baughman,K., Gould,G., Song,K.H., Strittmatter,S.M. Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth. Journal of Neurotrauma 2009; 26(-1-):81-95. >>> Ibuprofen; naproxen; PBS; SC; Rat; mice; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 11-12 wks old, 250-270 g., female, C57BL/6, 8-9 wks old, 20 g.); spinal cord injury; behavioral testing (BBB locomotor scale, Basso mouse scale).

P5919 Wagner,C., Vitzthum,H., Castrop,H., Schumacher,K., Bucher,M., Albertin,S., Coffman,T.M., Arendshorst,W.J., Kurtz,A. Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003; 447(-2-):214-222. >>> Bumetanide; ibuprofen; SC; Mice; 1007D; 7 days.

P1145 Orita,H., Girgis,W., diZerega,G.S. Prevention of postsurgical peritoneal adhesion formation by intraperitoneal administration of ibuprofen. Drug Dev.Res. 1987; 10(--):97-105. >>> Ibuprofen; PBS; Ringer's solution, lactated; IP; rabbit; 2002; 2ML1; 7, 14 days; controls rec'd mp w/ vehicle; mp connected to cath.; 2 exp.; varying doses of agent; ip + extraperitoneal pump placement; comparison of inject. vs. mp infusion; stress/adverse react. (fibrinous tissue).

top of page

5. Indomethacin

Q4542 Na,Y.R., Yoon,Y.N., Son,D., Jung,D., Gu,G.J., Seok,S.H., Seok,S.H. Consistent Inhibition of Cyclooxygenase Drives Macrophages towards the Inflammatory Phenotype. PLoS One 2015; 10(--):U1730-U1742. >>> NA-398; SC-560; indomethacin; DMSO; SC; Mice; 30 days; Controls received mp w/ vehicle; animal info (female, BALB/c); immunology;.

P4819 Babin,M.C., Ricketts,K., Skvorak,J.P., Gazaway,M., Mitcheltree,L.W., Casillas,R.P. Systemic administration of candidate antivesicants to protect against topically applied suitor mustard in the mouse ear vesicant model (MEVM ).. Journal of Applied Toxicology 2000; 20(--):S141-S144. >>> Hydrocortisone; indomethacin; olvanil; PEG 200; SC; mice; 2 days; Controls received mp w/ vehicle; toxicology.

P4475 Zlatnik,M.G., Buhimschi,I, Chwalisz,K., Liao,Q.-P., Saade,G.R., Garfield,R.E. The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.. Am.J.Obstet.Gynecol. 1999/5; 180(-5-):1191-1195. >>> Iloprost; Cicaprost; L-NAME; Indomethacin; Saline;; SC;; rat (pregnant);; 2ML2;; 2 weeks;; controls received mp w/vehicle; comparison of SC injections vs. mp; cardiovascular; L-NAME is a synthase inhibitor;.

P4207 Shimoda,K., Nomura,M., Kato,M. Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on Sparfloxacin-induced phototoxicity in mice. Fundam.Appl.Toxicol. 1996; 31(--):133-140. >>> Catalase; Dimethyl sulfoxide; Dexamethasone; Indomethacin; Pyrilamine maleate; AA-861; Cimetidine; Phenidone; Ethanol; Saline; SC; mice; 1007D; 72 hours; all agents infused concomitantly in the same pump; preliminary study conducted to test solubility and toxicity for 5 days; enzyme inhibitors; toxicology.

P3986 Henke,P.K., Bergamini,T.M., Watson,A.L., Brittian,K.R., Powell,D.W., Peyton,J.C. Bacterial products primarily mediate fibroblast inhibition in biomaterial infection. J.Surg.Res. 1998; 74(--):17-22. >>> Antibody, anti-interferon gamma; Antibody, indomethacin; Antibody, anti-TNFa; Antibody, interleukin 1 alpha; PBS, sterile; ETOH; Indomethacin; SC; mice; 1007D; 7 days; immunology; pump implanted next to Dacron graft; peptides.

P3918 Henke,P.K., Bergamini,T.M., Brittian,K.R., Polk Jr,H.C. Prostaglandin E2 modulates monocyte MHC-II (Ia) suppression in biomaterial infection. J.Surg.Res. 1997; 69(--):372-378. >>> Indomethacin; Antibody, anti-IL-1a; Antibody, anti-TNFa; PBS; ETOH; SC; Mice; 7 days; Controls received mp w/ vehicle; immunology.

P3614 Fernandez,M., Garcia-Pagan,J.C., Casadevall,M., Mourelle,M.I., Pique,J.M., Bosch,J., Rodes,J. Acute and chronic cyclooxygenase blockade in portal-hypertensive rats: influence on nitric oxide biosynthesis. Gastroenterol. 1996; 110(--):1529-1535. >>> Indomethacin; Sodium carbonate; SC; rat; 2ML2; 7 days; sonication used to suspend indomethacin.

P2852 Sakamoto,T., Soriano,D., Nassaralla,J., Murphy,T.L., Oganesian,A., Spec,C., Hinton,D.R., Ryan,S.J. Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Arch Ophthalmol. 1995; 113(--):222-226. >>> Indomethacin; GBR buffer; Cyclodextrin, B-; Eye (vitreous); monkey; 2ML2; 14 days; control eyes received mp with vehicles; enzyme inhibitor; indomethacin is a cyclooxygenase (COX) inhibitor; detailed description of vitreal cannula implantation; empty pump implanted at time of cannula implantation to allow 1-month recovery period; beta-cyclodextrin used as a carrier molecule; some monkeys served both as control and drug treatment group (different treatment in each eye); a vitreous opacity appeared in some eyes during infusion but disappeared after the pump was disconnected.

P1204 Schlegel,W., Doren,M., Cirkel,U., Schneider,H.P.G. Effect of continuous intrauterine administration of prostaglandin F2alpha and indomethacin on fertilization of rabbits. Horm.Metab.Res. 1986; 18(--):457-461. >>> Indomethacin; Prostaglandin F2a; HCl; Sodium hydroxide; Saline; intrauterine; rabbit; 2002; 11 days; controls received mp w/ vehicle; separate and simultaneous infusion of agents; comparison of agents effects; NaOH, HCl and saline were used in combination as the vehicle for indomethacin; many different exp.; tissue perfusion (cornua of uterus).

P1031 Doktorcik,P.E., Kennedy,T.G. 6-Keto-prostaglandin E1 and the decidual cell reaction in rats. Prostaglandins 1986; 32(-5-):679-689. >>> Indomethacin; Prostaglandin E1; Prostaglandin E2; Ethanol; Gelatin; PBS; intrauterine; rat; 2001; 5 days; mp w/vehicle; dose-response; indomethacin infused with prostaglandin E1 in one group and with prostaglandin E2 in another group; tissue perfusion (uterus).

P0794 Kennedy,T.G. Intrauterine infusion of prostaglandins and decidualization in rats with uteri differentially sensitized for the decidual cell reaction. Biol.Reprod. 1986; 34(-2-):327-335. >>> Indomethacin; Prostaglandin E2; Prostaglandin F2a; Ethanol; Gelatin; PBS; intrauterine; rat; 2001; 5 days; replacement therapy (ovariectomy); controls received mp w/ vehicle; estradiol and progesterone injected sc w/ mp PG infusion; vehicle contained indomethacin to reduce PG synthesis; tissue perfusion (uterus).

P0739 Kennedy,T.G. Evidence for the involvement of prostaglandins throughout the decidual cell reaction in the rat. Biol.Reprod. 1985; 33(--):140-146. >>> Indomethacin; Prostaglandin E2; Prostaglandin F2a; Ethanol; PBS; intrauterine; rat; 2001; 5 days; replacement therapy (ovariectomy); pumps primed overnight in saline; sc adminis. of agents in comb. w/mp infusion; separate and simultaneous infusion of agents; tissue perfusion (uterus).

top of page

6. Ketorolac

P8822 Scarlett,J.M., Jobst,E.E., Enriori,P.J., Bowe,D.D., Batra,A.K., Grant,W.F., Cowley,M.A., Marks,D.L. Regulation of central melanocortin signaling by interleukin-1beta. Endocrinology 2007; 148(-9-):4217-4225. >>> Ketorolac; Saline, sterile; SC; Mice; 1007D; 2 days; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 4-5 wks old).

P5091 Southall,M.D., Bolyard,L.A., Vasko,M.R. Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE(2)-mediated sensitization of rat sensory neurons. Pain 2002; 96(--):285-296. >>> Ketorolac tromethamine; Saline; CSF/CNS (intrathecal); rat; 2001; 48 hours; controls received mp w/ vehicle; ketorolac is an NSAID sold as Toradol; cannula patency verfied by saline injection.

P4204 Shufflebarger,J.V., Doyle,J., Roth,T., Maguire,K., Rothkopf,D.M. The effect of ketorolac on microvascular thrombosis in an experimental rabbit model. Plast.Reconstr.Surg. 1996; 98(--):140-145. >>> Ketorolac; IV (jugular); rabbit; 2ML1; 7 days; controls received mp w/saline; functionality of mp verified by residual volume; comparison of i.m. injections vs. mp; ketorolac also called Toradol; NSAID.

top of page

7. L-NAME

Q4123 Tain,Y.L., Huang,L.T., Lee,C.T., Chan,J.Y.H., Hsu,C.N., Tain,Y.L. Maternal Citrulline Supplementation Prevents Prenatal N(G)-Nitro-L-Arginine-Methyl Ester (L-NAME)-Induced Programmed Hypertension in Rats. Biology of Reproduction 2015; 92(--):U27-U33. >>> L-NAME; SC; Rat (pregnant); ; Animal info (female, Sprague Dawley, 10 weeks old); teratology; cardiovascular;.

Q4122 Tain,Y.L., Lee,C.T., Huang,L.T., Tain,Y.L. Long-Term Effects of Maternal Citrulline Supplementation on Renal Transcriptome Prevention of Nitric Oxide Depletion-Related Programmed Hypertension: The Impact of Gene-Nutrient Interactions. International Journal of Molecular Sciences 2014; 15(--):23255-23268. >>> L-NAME; SC; Rat (pregnant); ; Controls received mp w/ saline; animal info (female, Sprague Dawley, 10 weeks old); teratology; cardiovascular;.

Q3270 Zana-Taieb,E., Butruille,L., Franco-Montoya,M.L., Lopez,E., Vernier,F., Grandvuillemin,I., Evain-Brion,D., Deruelle,P., Baud,O., Delacourt,C., Jarreau,P.H. Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs: Morphometric and Gene Expression Analysis. PLoS One 2013; 8(-11-):U35-U45. >>> L-NAME; Saline; SC; Rat (pregnant); ; Controls received high protein diet; animal info (Female, Sprague Dawley); teratology.

Q3102 Kurabayashi,A., Kakinuma,Y., Morita,T., Inoue,K., Sato,T., Furihata,M. Conditional VHL Gene Deletion Causes Hypoglycemic Death Associated with Disproportionately Increased Glucose Uptake by Hepatocytes through an Upregulated IGF-I Receptor. PLoS One 2013; 8(-7-):U1405-U1415. >>> L-NAME; Insulin-like growth factor 1 receptor; Saline; acetic acid; SC; Mice; 14 days; Controls received mp w/ vehicle; animal info (VHL-KO); 25% acetic acid used; immunology.

Q3026 Abe,H., Ishikawa,W., Kushima,T., Nishimura,T., Mori,C., Onuki,A., Suzuki,T., Ishii,Y., Kansaku,N., Miyazaki,Y., Tanaka,K., Morita,H., Takizawa,T. Nitric Oxide Induces Vascular Endothelial Growth Factor Expression in the Rat Placenta in Vivo and in Vitro. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2013; 77(-5-):971-976. >>> L-NAME; SC; Rat (pregnant); 2001D; 24 hours; Animal info (Crj Wistar); enzyme inhibitor (NOS, nitric oxide).

Q2618 Butruille,L., Mayeur,S., Moitrot,E., Storme,L., Knauf,C., Lesage,J., Deruelle,P. Maternal hypertension induced by NO blockade does not program adult metabolic diseases in growth-restricted rat fetuses. METABOLISM-CLINICAL AND EXPERIMENTAL 2013; 62(-3-):442-445. >>> L-NAME; SC; Rat (pregnant); 2ML1; ; Control animals received mp w/ saline; animal info (Wistar Han, female, E17).

Q2196 Hale,S.A., Weger,L., Mandala,M., Osol,G. Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition. American Journal of Physiology-Heart and Circulatory Physiology 2011; 301(-4-):H1266-H1275. >>> L-NAME; SC; Rat (pregnant); 10 days; Controls received mp w/ saline; animal info (Sprague Dawley, female).

Q2193 Ivars,J., Butruille,L., Knauf,C., Bouckenooghe,T., Mayeur,S., Vieau,D., Valet,P., Deruelle,P., Lesage,J. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat. Peptides 2012; 35(-1-):136-138. >>> L-NAME; SC; Rat (pregnant); 5 days; Animal info (Wistar, female, E17); enzyme inhibitor (nitric oxide synthase, NOS);.

Q2087 Butruille,L., Mayeur,S., Duparc,T., Knauf,C., Moitrot,E., Fajardy,I., Valet,P., Storme,L., Deruelle,P., Lesage,J. Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat. European Journal of Pharmacology 2012; 689(-1-3-):278-284. >>> L-NAME; fasudil; SC; Rat (pregnant); ; Controls received mp w/ normal saline; animal info (Wistar Han, 200-250 g, E14, female); enzyme inhibitor (nitric oxide synthase, NOS, Rho-kinase, ROCK); one group contained mixture of fasudil and L-NAME; teratology.

Q1601 Neerhof,M.G., Synowiec,S., Khan,S., Thaete,L.G. Impact of Endothelin A Receptor Antagonist Selectivity in Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat. HYPERTENSION IN PREGNANCY 2010; 29(-3-):284-293. >>> FR139317; L-NAME; A-127722; ABT-546; Saline; ethyl alcohol; propylene glycol; NaOH; SC; IV (jugular); Rat; 2ML1; 7 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, female, 11-20 wks old, 225-250 g); FR139317 is a tripeptide with 8000-fold selectivity for ETA23; peptides; multiple pumps used (2); enzyme inhibitor (NOS, nitric oxide synthase); ABT-546 is a nonpeptide ETA antagonist.

Q1577 Chung,E., Zelinski,L.M., Ohgami,Y., Shirachi,D.Y., Quock,R.M. Hyperbaric Oxygen Treatment Induces a 2-Phase Antinociceptive Response of Unusually Long Duration in Mice. JOURNAL OF PAIN 2010; 11(-9-):847-853. >>> L-NAME; naltrexone; Saline, physiological; CSF/CNS; Mice; 2001; ; Controls received mp w/ vehicle; animal info (NIH, Swiss, 18-22 g); ALZET brain infusion kit used; hyperbaric oxygen.

Q1403 Wroblewska-Seniuk,K., Nowicki,S., Le Bouguenec,C., Nowicki,B., Yallampalli,C. Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats. American Journal of Obstetrics and Gynecology 2011; 205(-1-):U242-U248. >>> L-NAME; Rat (pregnant); 2ML1; ; Controls received mp w/ vehicle; animal info (Sprague Dawley, female, timed-pregnant); enzyme inhibitor (NOS, nitric oxide synthase).

Q1338 Suzuki,T., Nagamatsu,C., Kushima,T., Miyakoshi,R., Tanaka,K., Morita,H., Sakaue,M., Takizawa,T. Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation. EXPERIMENTAL BIOLOGY AND MEDICINE 2010; 235(-4-):455-462. >>> L-NAME; SC; Rat (pregnant); 2ML1; 24, 48 hours; Animal info (female, Crj, Wistar, 10-15 wks old); enzyme inhibitor (NOS).

Q1125 Hu,X.L., Atzler,D., Xu,X., Zhang,P., Guo,H.P., Lu,Z.B., Fassett,J., Schwedhelm,E., Boeger,R.H., Bache,R.J., Chen,Y.J. Dimethylarginine Dimethylaminohydrolase-1 Is the Critical Enzyme for Degrading the Cardiovascular Risk Factor Asymmetrical Dimethylarginine. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-7-):1540-U145. >>> L-NAME; SC; Mice; 72 hours; Wild type controls received mp w/ L-NAME; animal info (DDAH1 -/-).

Q1078 Gao,J., Zhang,H., Le,K.D., Chao,J., Gao,L. Activation of Central Angiotensin Type 2 Receptors Suppresses Norepinephrine Excretion and Blood Pressure in Conscious Rats. American Journal of Hypertension 2011; 24(-6-):724-730. >>> Compound 21; L-NAME; CSF, artificial; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 290-380 g); ALZET brain infusion kit used.

Q0933 Thaete,L.G., Neerhof,M.G., Silver,R.K. Differential Effects of Endothelin A and B Receptor Antagonism on Fetal Growth in Normal and Nitric Oxide-Deficient Rats. J.Soc.Gynecol.Invest. 2001; 8(-1-):18-23. >>> FR-139317; L-NAME; A-127722; A-182086; Ethyl alcohol; propylene glycol; sodium hydroxide; water; IV (jugular); Rat (pregnant); 7 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley); teratology; peptides; multiple pumps per animal (2); 20% ethyl alcohol used; wound clips used.

Q0932 Thaete,L.G., Neerhof,M.G. ENDOTHELIN AND BLOOD PRESSURE REGULATION IN THE FEMALE RAT: STUDIES INNORMAL PREGNANCY AND WITH NITRIC OXIDE SYNTHASE INHIBITION-INDUCEDHYPERTENSION. HYPERTENSION IN PREGNANCY 2011; 19(-2-):233-247. >>> A-127722; A-182086; A-192621; FR-139317; L-NAME; Ethyl alcohol; propylene glycol; NaOH; water; SC; IV (jugular); Rat (pregnant); rat; 7 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley); multiple pumps per animal (2); wound clips used; 20% ethyl alcohol used; "It is likely that administration with the pumps resulted in more consistent drug levels..." pg 242.

Q0889 Mihout,F., Shweke,N., Bige,N., Jouanneau,C., Dussaule,J.C., Ronco,P., Chatziantoniou,C., Boffa,J.J. Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-beta 1 synthesis. Journal of Pathology 2011; 223(-1-):37-45. >>> L-NAME; dimethylarginine, asymmetric; SC; Mice; 8 weeks; Controls received mp w/ iso-osmotic saline serum; animal info (23 g, male, SV129, 8 wks old, uninephrectomized); long-term study; enzyme inhibitor (nitric oxide synthase, NOS).

Q0800 Neerhof,M.G., Synowiec,S., Khan,S., Thaete,L.G. Pathophysiology of Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat. HYPERTENSION IN PREGNANCY 2011; 30(-1-):28-36. >>> L-NAME; ABT-546; Saline; ethyl alcohol; SC; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; animal info (female, male, Sprague-Dawley, 11-20 wks old, 225-250 g); multiple pumps per animal (2).

Q00029 Santhanam,L., Tuday,E.C., Webb,A.K., Dowzicky,P., Kim,J.H., Oh,Y.J., Sikka,G., Kuo,M., Halushka,M.K., Macgregor,A.M., Dunn,J., Gutbrod,S., Yin,D., Shoukas,A., Nyhan,D., Flavahan,N.A., Belkin,A.M., Berkowitz,D.E. Decreased S-Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness. Circulation Research 2010; 107(-1-):117-U243. >>> L-NAME; Cystamine; Mice; rat; 3 months; 4 weeks; Controls received mp w/vehicle; cardiovascular; enzyme inhibitor (NO synthase; transglutaminase); animal info (male, BL6129S wt, TG2 -/-, 3-5 months old; Fisher 344, 18-19 months old); pumps replaced every 4 weeks; long-term study.

P9971 Xue,B.J., Singh,M., Guo,F., Hay,M., Johnson,A.K. Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-5-):H1638-H1646. >>> L-NAME; L-VNIO; Angiotensin II; SC; CSF/CNS; Mice; 1002; 7, 14 days; Controls received mp w/ vehicle; peptides; cardiovascular; enzyme ihibitor (NO synthase); animal info (male, female, C57BL/6, 12-16 weeks old); replacement therapy (ovariectomy, gonadectomy); cannula placement confirmed post mortem histologically; N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO).

P8527 Ravishankar,V., Buhimschi,C.S., Booth,C.J., Bhandari,V., Norwitz,E., Copel,J., Buhimschi,I.A. Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition. American Journal of Obstetrics and Gynecology 2007; 196(-5-):U104-U111. >>> L-NAME; Saline, sterile; SC; Rat (pregnant); 2ML1; 4 days; Controls received mp w/ vehicle; enzyme inhibitor (NO synthase); animal info (female, Sprague-Dawley, G-D17, 300-350 g).

P8511 Clarkson,A.N., Liu,H., Schiborra,F., Shaw,O., Sammut,I.A., Jackson,D.M., Appleton,I. Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research 2007; 1171(--):111-121. >>> Clomethiazole; L-NAME; SC; Rat; 2ML1; 5 days; Controls received mp w/ vehicle or saline or no treatment; no stress (see pg. 112); enzyme inhibitor (NO synthase); ischemia (cerebral); animal info (male, Wistar, 21 days old).

P8455 Ebose,E.J., Campbell,P.I., Okorodudu,A.O. Electrolytes and pH changes in pre-eclamptic rats. Clinica Chimica Acta 2007; 384(-1-2-):135-140. >>> L-NAME; Saline, sterile, isotonic; SC; Rat (pregnant); 2ML2; 2 days; Controls received mp w/ vehicle; enzyme inhibitor (NOS); animal info (female, Sprague-Dawley, 270-340g, GD15).

P8361 Gangula,P.R.R., Maner,W.L., Micci,M.A., Garfield,R.E., Pasricha,P.J. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. American Journal of Physiology-Gastrointestinal and Liver Physiology 2007; 292(-3-):G725-G733. >>> L-NAME; SC; Rat; 2ML1; 4 days; Replacement therapy (STZ-induced diabetes mellitus; enzyme inhibitor (nitric oxide synthase); animal info (male, female, Sprague-Dawley, 7 wks old).

P8327 Schwenke,D.O., Pearson,J.T., Mori,H., Shirai,M. Does central nitric oxide elicit pulmonary hypertension in conscious rats?. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2006; 153(-3-):250-260. >>> L-NAME; SIN-1; CSF, artificial; CSF/CNS; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; enzyme inhibitor (NO synthase); cardiovascular; animal info (male, Sprague-Dawley, 200-320 grams, 8 weeks old); Evans blue dye used to confirm correct cannula placement; SIN-1 is 2-[4-morpholinyl]-sydnonimine-hydrochloride.

P8301 Badn,W., Hegardt,P., Fellert,M.A., Darabi,A., Esbjoernsson,M., Smith,K.E., Janelidze,S., Salford,L.G., Visse,E., Siesjoe,P. Inhibition of inducible nitric oxide synthase enhances anti-tumour immune responses in rats immunized with IFN-gamma-secreting glioma cells. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2007; 65(-3-):289-297. >>> L-NAME; L-NIL; Saline; IP; Rat; 2001; 1 week; 14, 28 days; Controls received mp w/ vehicle; dose-response (fig. 3); comparison of IP injections vs. mp; enzyme inhibitor (Nitric oxide synthase, iNOS); cancer (glioma); L-NIL is L-N6- (1-iminsethyl) -L-lysine.

P8215 Aikawa,K., Chichester,P., Whitbeck,C., Levin,R.M. Effect of nitric oxide synthase inhibition on changes induced by estradiol in bladders from ovariectomized rabbits. UROLOGIA INTERNATIONALIS 2005; 75(-2-):133-138. >>> L-NAME; Saline; SC; Rabbit; 4 weeks; Controls received sham OVX w/ no mp; enzyme inhibitor (NO synthase); animal info (female, New Zealand White, 3.5-4.0 kg.).

P7889 Coates,B.J., Broderick,T.L., Batia,L.M., Standley,C.A. MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia. American Journal of Obstetrics and Gynecology 2006; 195(-5-):1398-1403. >>> L-NAME; magnesium sulfate; Saline; SC; Rat (pregnant); 2ML1; 4 days; Controls received mp w/ vehicle; cardiovascular; animal info (female, Sprague-Dawley, 150-175g.); "Infusion of L-NAME in pregnant rats represent an excellent animal model suitable for the study of cardiovascular dysfunction in preeclampsia." (pg. 1401).

P7747 Schwenke,D.O., Pearson,J.T., Kangawa,K., Shirai,M. Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?. ACTA PHYSIOLOGICA 2006; 186(-4-):309-318. >>> L-NAME; sydnonimine-hydrochloride, 3-[4-morpholinyl]-; CSF, artificial; CSF/CNS; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; no stress (see pg. 312); enzyme inhibitor (no synthase); post op. care (viccillin); animal info (male, Sprague-Dawley, 8 wk. old, 200-320g.); correct catheter positioning confirmed post mortem w/ Evans blue dye.

P7299 Takei,H., Yamamoto,M., Kase,Y., Takeda,S. The effect of herbal medicine Toki-shakuyaku-san on blood pressure in an Nw-nitro-L-arginine methyl ester-induced pre-eclampsia rat model during pregnancy and the postpartum period. JOURNAL OF PHARMACOLOGICAL SCIENCES 2005; 98(-3-):255-262. >>> L-NAME; SC; Rat (pregnant); 2ML2; 2 weeks; Controls received mp w/ saline; enzyme inhibitor (NO synthase); cardiovascular.

P7204 Pfosser,A., Thalgott,M., Buettner,K., Brouet,A., Feron,O., Boekstegers,P., Kupatt,C. Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia. Cardiovascular Research 2005; 65(-3-):728-736. >>> Geldanamycin; L-NAME; SC; Rabbit; 25, 28 days; Enzyme inhibitor (Hsp90, NO synthase).

P7179 Jacobi,J., Sydow,K., von Degenfeld,G., Zhang,Y., Dayoub,H., Wang,B.Y., Patterson,A.J., Kimoto,M., Blau,H.M., Cooke,J.P. Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Circulation 2005; 111(-11-):1431-1438. >>> L-NAME; dimethylarginine, asymmetric; PBS; SC; IP; Mice; mice (transgenic); 2002; 2004; 2, 3 weeks; Controls received mp w/ vehicle; enzyme inhibitor (nitric oxide synthase); cardiovascular; ischemia (hindlimb).

P7049 Bourraindeloup,M., Adamy,C., Candiani,G., Cailleret,M., Bourin,M.C., Badoual,T., Su,J.B., Adubeiro,S., Roudot-Thoraval,F., Dubois-Rande,J.L., Hittinger,L., Pecker,F. N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats. Circulation 2004; 110(-14-):2003-2009. >>> L-NAME; SC; Rat; 2ML4; 4,6 weeks; Functionality of mp verified by systolic blood pressure; pumps replaced after 4 weeks; enzyme inhibitor (no synthase); cardiovascular.

P7024 De Seranno,S., Estrella,C., Loyens,A., Cornea,A., Ojeda,S.R., Beauvillain,J.C., Prevot,V. Vascular endothelial cells promote acute plasticity in ependymoglial cells of the neuroendocrine brain. Journal of Neuroscience 2004; 24(-46-):10353-10363. >>> L-NAME; Sodium chloride; CSF/CNS (median eminence); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by determining correct cannula placement and exhaustion of infusion solution; enzyme inhibitor (NOS).

P6953 Thaete,L.G., Kushner,D.M., Dewey,E.R., Neerhof,M.G. Endothelin and the regulation of uteroplacental perfusion in nitric oxide synthase inhibition-induced fetal growth restriction. PLACENTA 2005; 26(-2-3-):242-250. >>> L-NAME; A-127722; Saline; ethyl alcohol; NaOH; water; propylene glycol; SC; Rat (pregnant); 2ML1; 1,4,7 days; Functionality of mp verified by residual volume; stability verified by prior experiment (24 days); multiple pumps per animal (2); drugs infused in separate pumps; A-127722 (ETA receptor antagonist) was dissolved in 20% alcohol, 40% PG and 0.04 M of NaOH.

P6655 Li,X., Simard,J.M. Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHR. Hypertension 2002; 40(-6-):940-946. >>> Angiotensin II; L-NAME; captopril; SC; Rat; 4 weeks; Enzyme inhibitor (nitric oxide synthase); cardiovascular; antihypertensive.

P6488 Wheeler,M.T., Allikian,M.J., Heydemann,A., Hadhazy,M., Zarnegar,S., McNally,E.M. Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. Journal of Clinical Investigation 2004; 113(-5-):668-675. >>> L-NAME; IP; Mice (transgenic); 6 days; Controls received mp w/ saline; enzyme inhibitor (no synthase); cardiovascular.

P6318 Steudel,W., Ichinose,F., Huang,P.L, Hurford,W.E., Jones,R.C., Bevan,J.A., Fishman,M.C, Zapol,W.M. Pulmonary Vasoconstriction and Hypertension in Mice With Targeted Disruption of the Endothelial Nitric Oxide Synthase (NOS 3) Gene. Circulation Research 1997; 81(-1-):34-41. >>> L-NAME; Saline, normal; IP; Mice; 1007D; 5 days; Controls received no treatment; comparison of acute IV injections vs. mp; enzyme inhibitor (nitric oxide synthase); cardiovascular.

P6271 McDonald,W.S., Lo,TP Jr, Thurmond,M., Jones,C., Cohen,R., Miller,A., Beasley,D. Role of nitric oxide in skin flap delay. PLASTIC AND RECONSTRUCTIVE SURGERY 2004; 113(-3-):927-931. >>> L-NAME; IP; Mice; 1003D; ; Functionality of mp verified by residual volume; dose-response (p. 929); enzyme inhibitor (NOS).

P6257 Elger,W., Beier,S., Pollow,K., Garfield,R., Shi,S.Q., Hillisch,A. Conception and pharmacodynamic profile of drospirenone. Steroids 2003; 68(-10-13-):891-905. >>> L-NAME; SC; Rat (pregnant); 10 days; Teratology; pump model not listed.

P6083 Turban,S., Wang,X.Y., Knepper,M.A. Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. American Journal of Physiology-Renal Physiology 2003; 285(-5-):F843-F851. >>> Angiotensin II; aldosterone; L-NAME; Acetic acid; DMSO; saline; water; SC; Rat; 2001; 2ML1; 7 days; Controls received mp w/ vehicle; peptides; angiotensin II dissolved in acetic acid; albo dissolved in 30% DMSO/saline; L-NAME dissolved in water.

P5994 Murase,T., Tian,Y., Fang,X.Y., Verbalis,J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; 5 days; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

P5917 Packer,M.A., Stasiv,Y., Benraiss,A., Chmielnicki,E., Grinberg,A., Westphal,H., Goldman,S.A., Enikolopov,G. Nitric oxide negatively regulates mammalian adult neurogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003; 100(-16-):9566-9571. >>> L-Name; D-Name; Calcium; Hank's buffered saline; CSF/CNS; Rat; 2002; ; Enzyme inhibitor (nitric oxide synthase).

P5906 Nadeau,S., Rivest,S. Glucocorticoids play a fundamental role in protecting the brain during innate immune response. Journal of Neuroscience 2003; 23(-13-):5536-5544. >>> Tumor necrosis factor-alpha; L-NAME; endotoxin, LPS; Saline; BSA; ascorbic acid; PIPES; DMSO; CSF/CNS (cortex, dorsal basal ganglia); Rat; 2004; 3,7,14,21 days; Controls received mp w/ vehicle; tissue perfusion (cerebral tissue&dorsal ganglia); enzyme inhibitor (nitric oxide); brain tissue distribution; guid cannula used; TNF-a was dissolved in saline + 0.1% BSA + 0.01% ascorbic acid; L-NAME was dissolved in PIPES&10% DMSO&infused into the dorsal basal ganglia.

P5899 Kurisu,S., Ozono,R., Oshima,T., Kambe,M., Ishida,T., Sugino,H., Matsuura,H., Chayama,K., Teranishi,Y., Iba,O., Amano,K., Matsubara,H. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 2003; 41(-1-):99-107. >>> Angiotensin II; HOE 140; L-NAME; Saline; SC; Mice (transgenic); 2002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (no); cardiovascular; HOE140 is a bradykinin B2 receptor antagonist; L-NAME is a nitric oxide synthase inhibitor; table on p. 101 for weights, blood pressure, heart rate, etc..

P5846 Nemade,R.V., Carrette,O., Larsen,W.J., Markoff,E. Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst development. Fertility and Sterility 2002; 78(-6-):1301-1308. >>> L-NAME; D-NAME; Gonadotrophin, human chorionic; Water, sterile; SC; Mice; 1003D; 1007D; 3,4,7 days; Functionality of mp verified by plasma levels taken; enzyme inhibitor (nitric oxide synthase) "L-NAME"; multiple pumps per animal in some groups; human choriogonadotropin is (hCG).

P5730 Buckwalter,J.B., Curtis,V.C., Valic,Z., Ruble,S.B., Clifford,P.S. Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide. Journal of Applied Physiology 2003; 94(-3-):935-940. >>> L-NAME; D-NAME; Phenylephrine; Saline; heparin; IA (femoral); Rabbit; 2ML2; 6 weeks; Controls received mp w/ phenylephrine or D-NAME; enzyme inhibitor (Nitric oxide synthase); cardiovascular; peptides; L-NAME&D-NAME (no synthase inhibitors) were dissolved in heparinized saline (100 U/ml).

P5611 Witlin,A.G., Gangula,P.R.R., Wimalawansa,S.J., Grafe,M., Grady,J.J., Yallampalli,C. Adrenomedullin requires an intact nitric oxide system to function as a nendogenous vasodilator in rat gestation. HYPERTENSION IN PREGNANCY 2003; 22(-1-):9-24. >>> Adrenomedullin, human; L-NAME; SC; Rat (pregnant); 1003D; 2001D; 2ML1; 2ML2; 1-5 days; Controls received mp/w vehicle; dose-response (table, p. 17); teratology; peptides; antihypertensive; agents infused individually or in combination..

P5371 Tam,S.L., Sims,E., Kaufman,S. Effect of NOS inhibition on central response to atrial distension during pregnancy. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-4-):R827-R831. >>> L-NAME; D-NAME; SC; Rat (pregnant); 2ML1; ; Enzyme inhibitor.

P5300 Horstman,D.J., Fischer,L.G., Kouretas,P.C., Hannan,R.L., Rich,G.F. Role of nitric oxide in heparin-induced attenuation of hypoxic pulmonary vascular remodeling. J Appl.Physiol 2002/5; 92(-5-):2012-2018. >>> L-NAME; Heparin; Saline; SC; Rat; 2ML4; 3 days or 3 weeks; Controls received mp w/ vehicle; cardiovascular; 24 hour recovery period.

P5241 Murakami,H., Miao,R.Q., Chao,L., Chao,J. Adenovirus-mediated kallikrein gene transfer inhibits neointima formation via increased production of nitric oxide in rat artery. Immunopharmacology 1999/10/15; 44(-1-2-):137-143. >>> L-NAME; IP; Rat; 2ML2; 2 weeks; Cardiovascular.

P5156 Tam,S.L., Kaufman,S. NOS inhibition restores renal responses to atrial distension during pregnancy. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 282(--):R1364-R1367. >>> L-NAME; D-NAME; SC; rat (pregnant); 2ML1; 6 days; controls received mp w/ inactive agent; cardiovascular; enzyme inhibitor (NOS).

P5107 Murakami,H, Miao,R.Q, Chao,L, Chao,J. Adenovirus-mediated kallikrein gene transfer inhibits neointima formation via increased production of nitric oxide in rat artery. Immunopharmacology 1999; 44(--):137-143. >>> L-NAME; IP; rat; 2ML2; 14 days; cardiovascular; L-Name is an enzyme inhibitor (NO synthase).

P4877 Ikegaki,I., Hattori,T., Yamaguchi,T., Sasaki,Y., Satoh,S., Asano,T., Shimokawa,H. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. European Journal of Pharmacology 2001; 427(--):69-75. >>> L-NAME; IP; rat; 2ML4; 28 days; controls received no treatment; cardiovascular; L-NAME is a nitric oxide synthesis inhibitor.

P4784 Buhimschi,I.A., Shi,S.Q., Saade,G.R., Garfield,R.E. Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies.. American Journal of Obstetrics and Gynecology 2001; 184(-4-):686-693. >>> L-NAME; Saline;; SC;; rat (pregnant);; 2ML2; 2ML4;; 14 or 28 days;; Controls received mp w/ vehicle; teratology; enzyme inhibitor; L-NAME is a nitric oxide synthase inhibitor;.

P4673 Paterson,S, Zheng,Y, Smith,P.F., Darlington,C.L. The effects of L-NAME on vestibular compensation and NOS activity in the vestibular nucleus, cerebellum and cortex of the guinea pig.. Brain Research 2000; 879(--):148-155. >>> L-NAME; Saline; SC; Guinea-pig; 1003D; 50 hours; Controls received mp w/ vehicle; functionality of mp verified by nitric oxide synthase activity; dose-response (p. 153); enzyme inhibitor; L-NAME is a nitric oxide synthase inhibitor;.

P4623 Wimalawansa,S.J, Yallampalli,C. Pre-eclamptic toxemia: potential new therapy based on animal studies.. Ceylon Medical Journal 1998; 43(--):138-144. >>> L-NAME; Calcitonin gene-related peptide; Saline, sterile;; SC;; rat(pregnant);; 2ML1;; 1 week;; controls received mp w/ vehicle; peptides; CGRP and L-NAME or vehicle delivered from separate pumps concomitantly..

P4585 Wang,H.H, Lautt,W.W. Evidence of nitric oxide, a flow-dependent factor, being a trigger of liver regeneration in rats.. Can.J.Physiol.Pharmacol. 1998; 76(--):1072-1079. >>> L-NAME; Saline;; SC;; rat;; 2ML1;; ; controls received mp w/vehicle; functionality of mp verified by plasma levels;.

P4527 Bosmans,J.M, Vrints,C.J, Kockx,M.M, Bult,H, Cromheeke,K.M.C, Herman,A.G. Continuous perivascular L-Arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation.. Arterioscler.Thromb.Vasc.Biol. 1999; 19(--):767-776. >>> L-NAME; Arginine, L;; Water, deionized; NaCl, sterile;; IP;; rabbit;; 2ML2;; 2 weeks;; controls received mp w/vehicle; functionality of mp verified by residual volume and plasma levels; cardiovascular;.

P4510 Nowicki,B, Singhal,J, Fang,L, Nowicki,S, Yallampalli,C. Inverse relationship between severity of experimental pyelonephritis and nitric oxide production in C3H/HeJ mice.. Infection and Immunity 1999/5; 67(-5-):2421-2427. >>> L-NAME; Saline;; SC;; mice;; ; controls received mp w/vehicle;.

P4475 Zlatnik,M.G., Buhimschi,I, Chwalisz,K., Liao,Q.-P., Saade,G.R., Garfield,R.E. The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.. Am.J.Obstet.Gynecol. 1999/5; 180(-5-):1191-1195. >>> Iloprost; Cicaprost; L-NAME; Indomethacin; Saline;; SC;; rat (pregnant);; 2ML2;; 2 weeks;; controls received mp w/vehicle; comparison of SC injections vs. mp; cardiovascular; L-NAME is a synthase inhibitor;.

P4440 Danielson,L.A, Conrad,K.P. Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade on conscious pregnant rats.. Circ.Res. 1996; 79(--):1161-1166. >>> L-NAME; Saline;; SC;; rat (pregnant);; 48 hours;; controls received mp w/vehicle; cardiovascular.

P4241 Ou,J., Carlos,T.M., Watkins,S.C., Saavedra,J.E., Keefer,L.K., Kim,Y.-M., Harbrecht,B.G., Billiar,T.R. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide: Biology&Chemistry 1997; 1(-5-):404-416. >>> Aminoguanidine; Lysine, L-N6-(1-imino-ethyl)-; V-PYRRO/NO; L-NAME; L-NMA; Saline; IV (jugular); IV (gastric); rat; 2001D; 16 hours; controls received mp w/vehicle; good methods (p. 406); nitric oxide synthase inhibitors; PE10 catheter tubing inserted in gastric vein; some animals implanted with one pump for gastric vein and one for jugular vein; NMA is NG-monomethyl-L-arginine.

P3894 Rose,A.S., Prazma,J., Randell,S.H., Baggett,H.C., Lane,A.P., Pillsbury,H.C. Nitric oxide mediates mucin secretion in endotoxin-induced otitis media with effusion. Otolaryngol Head Neck Surg 1997; 116(--):308-316. >>> L-NAME; Kreb's solution; ear (tympanic bulla); rat; 2001; 7 days; controls received mp w/vehicle; tissue perfusion (tympanic bulla); good diagram of pump implantation (pg. 310).

P3861 Chatterjee,S., Collins,T.J., Yallampalli,C. Inhibition of nitric oxide facilitates LH release from rat pituitaries. Life Sci. 1997; 61(-1-):45-50. >>> Nitroglycerin; L-NAME; SC; rat; 2ML1; 36 hours; controls received mp w/saline.

P3836 Nakamura,T. Contribution of L-arginine-derived nitric oxide to the structural integrity of coronary artery and cardiac interstitium, and to the regulation of sympathetic nerve activity: assessment using a rat model produced by chronic nitric oxide inhibition. Hokkaido J.Med.Sci. 1997; 72(-5-):503-516. >>> L-NAME; IP; rat; 2ML4; 4,8 weeks; controls received mp w/saline; dose-response; long-term study, pumps replaced after 4 weeks; cardiovascular.

P3787 Bosmans,J.M, Vrints,C.J, Kockx,M.M, Bult,H, Cromheeke,K.M.C, Herman,A.G. Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. Arterioscler Thromb Vasc Biol 1998; 19(-3-):767-776. >>> Arginine,L-; L-NAME; Water, deionized; Perivascular; Rabbit; 2ML2; 2 weeks; Controls received mp w/ saline; functionality of mp verified by residual volume; cardiovascular; Restenosis; L-arginine plasma levels checked.

P3695 Liao,Q.-P., Buhimschi,I.A., Saade,G., Chwalisz,K., Garfield,R.E. Regulation of vascular adaptation during pregnancy and post-partum: effects of nitric oxide inhibition and steroid hormones. Human Reproduction 1996; 11(-12-):2777-2784. >>> L-NAME; Saline, sterile; SC; rat (pregnant); 2ML2; 14 days; controls received mp w/ vehicle; agent is NOS inhibitor.

P3690 Pfeiffer,C.J., Qiu,B.S. Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats. J.Pharm.Pharmacol. 1995; 47(--):827-832. >>> L-NAME; SC; rat; 2002; 8 days; controls received mp w/ saline; agent nitric oxide synthase inhibitor.

P3630 Qiu,B.S., Pfeiffer,C.J., Cho,C.H. Effects of chronic nitric oxide sythase inhibition in cold-restraint and ethanol-induced gastric mucosal damage in rats. Digestion 1996; 57(--):60-66. >>> L-NAME; NaCl; SC; rat; 2002; 10 days; functionality of mp verified by hypertension after 5 days; dose response (see pg. 62); bupivacaine HCl given to minimize post-operative pain.

P3547 Gangula,P.R.R., Wimalawansa,S.J., Yallampalli,C. Progesterone up-regulates vasodilator effects of calcitonin gene-related peptide in NG-nitro-L-arginine methyl ester-induced hypertension. Am.J.Obstet.Gynecol. 1997; 176(--):894-900. >>> L-NAME; Calcitonin gene-related peptide; Saline, sterile; SC; rat (pregnant); 2ML2; no duration posted; controls received mp w/ saline; peptides; agents given singly and concomitantly in the same pump; cardiovascular.

P3408 Sander,M., Hansen,J., Victor,R.G. The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by No-nitro-L-arginine methyl ester. Hypertension 1997; 30(-Pt 1-):64-70. >>> L-NAME; IP; IV (jugular); rat; 2ML1; 6 days; comparison of bolus injections vs. mp; cardiovascular.

P3333 Thomas,D.A., Ren,K., Besse,D., Ruda,M.A., Dubner,R. Application of nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester, on injured nerve attentuates neuropathy-induced thermal hyperalgesia in rats. Neurosci.Lett. 1996; 210(--):124-126. >>> L-NAME; D-NAME; SC; CSF/CNS (sciatic nerve); rat; 2001; 2 weeks; controls received mp w/saline; tissue perfusion (nerve cuff); comparison of systemic vs. targeted infusion; pumps replaced on day 8.

P3169 Shudo,H. L-arginine-nitric oxide pathway: nitric oxide.  1994; 69(-4-):967-977. >>> L-NAME; IP; rat; 4 weeks; controls received mp with saline; abstract and graphs in English; paper in Japanese.

P2589 Cayatte,A.J., Palacino,J.J., Horten,K., Cohen,R.A. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler.Thromb. 1994; 14(-5-):753-759. >>> L-NAME; Water, deionized; SC; rabbit; 2ML4; 4 weeks; enzyme inhibitor; nitric oxide synthase inhibitor;.

P2588 Khan,F., Palacino,J.J., Coffman,J.D., Cohen,R.A. Chronic inhibition of nitric oxide production augments skin vasoconstriction in the rabbit ear. J.Cardiovasc.Pharmacol. 1993; 22(-2-):280-286. >>> L-NAME; Water, deionized; SC; rabbit; 2ML4; 2 or 4 weeks; controls received mp w/ saline; enzyme inhibitor; nitric oxide synthase inhibitor;.

P2587 Adams,M.L., Kalicki,J.M., Meyer,E.R., Cicero,T.J. Inhibition of the morphine withdrawal syndrome by a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester. Life Sci. 1993; 52(--):L-249. >>> L-NAME HCl; Saline; Water; SC; rat; 2001; 7 days; controls received mp w/ saline; dependence; enzyme inhibitor; nitric oxide synthase inhibitor.

P2586 Yallampalli,C., Garfield,R.E. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am.J.Obstet.Gynecol. 1993; 169(--):1316-1320. >>> L-NAME; Nitroglycerin; Saline; SC; rat (pregnant); 2ML2; no duration posted; controls received mp w/ saline only; L-nitro-arginine methyl ester is L-NAME and is a nitric oxide synthase inhibitor; teratology; enzyme inhibitor.

P2585 Garcia-Pagan,J.C., Fernandez,M., Bernadich,C., Pizcueta,P., Pique,J.M., Bosch,J., Rodes,J. Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rat. Am.J.Physiol. 1994; 267(-30-):G984-G990. >>> L-NAME; Saline; SC; rat; 2ML2; 4 or 8 days; controls received mp w/ vehicle or no surgery; stability verified at 37 degrees by earlier 14-day bolus injection study; enzyme inhibitor; nitric oxide synthase inhibitor;.

top of page

8. Lonazolac

S0361 Khalil,H., Vancaillie,T., Schlegel,W. The use of lonazolac (LON) and indomethacin (IND) and its influence on ovum transport (OT) in the rabbit. 7th International Congress of Endocrinology Abstracts, July 1-7, Quebec City, Canada, Excerpta Medica, Princeton 1984; (--):505-. >>> Lonazolac; Indomethacin; intrauterine; rabbit; 2ML1; no duration posted; comparison of single vaginal drug application vs. mp infusion; comparison of agents effects; tissue perfusion (uterus).

top of page

9. Meclofenamate

P1305 Sargent,E.L., Baughman,W.L., Novy,M.J., Stouffer,R.L. Intraluteal infusion of a prostaglandin synthesis inhibitor, sodium meclofenamate, causes premature luteolysis in rhesus monkeys. Endocrinology 1988; 123(-5-):2261-2269. >>> Meclofenamate, sodium; Saline; Water; intraovarian (corpus luteum); IV (jugular); monkey; 2ML1; 7 days; stress/adverse reaction (cortisol and progesterone levels); tissue perfusion.

top of page

10. Naproxen

Q4700 Baj-Rossi,C., Jost,T.R., Cavallini,A., Grassi,F., De Micheli,G., Carrara,S. Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor. BIOSENSORS&BIOELECTRONICS 2014; 53(--):283-287. >>> Naproxen; Methanol; In Vitro; 1002; 16 hours; Functionality of mp verified by naproxen levels measured with sensors;.

Q3710 Rosa,A.C., Pini,A., Lucarini,L., Lanzi,C., Veglia,E., Thurmond,R.L., Stark,H., Masini,E., Masini,E. Prevention of Bleomycin-Induced Lung Inflammation and Fibrosis in Mice by Naproxen and JNJ7777120 Treatment. Journal of Pharmacology and Experimental Therapeutics 2014; 351(--):308-316. >>> JNJ7777120; naproxen; SC; Mice; 1004; ; Control animals received mp w/ vehicle; animal info (male, C57BL/6, ~2 mo old, 25-30 g); infusion rate listed as 0.11 ul/hr; JNJ7777120 also known as (1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine), is a selective H4R antagonist; one group received combination of JNJ7777120 and naproxen.

P9697 Wang,X.X., Budel,S., Baughman,K., Gould,G., Song,K.H., Strittmatter,S.M. Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth. Journal of Neurotrauma 2009; 26(-1-):81-95. >>> Ibuprofen; naproxen; PBS; SC; Rat; mice; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 11-12 wks old, 250-270 g., female, C57BL/6, 8-9 wks old, 20 g.); spinal cord injury; behavioral testing (BBB locomotor scale, Basso mouse scale).

P1504 Chan,W.Y., Berezin,I., Daniel,E.E. Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats. Biol.Reprod. 1988; 39(--):1117-1128. >>> Naproxen, sodium; Saline; SC; rat (pregnant); 2001; 3 days; no comment posted.

top of page

11. Superoxide Dismutase-PEG

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3114 Truelove,D., Shuaib,A., Ijaz,S., Ishaqzay,R., Kalra,J. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils. Free Rad.Biol.Med. 1994; 17(-5-):445-450. >>> Superoxide dismutase-PEG; Saline; CSF/CNS; gerbil; 1007D; 6 days; controls received mp with vehicle; ischemia (cerebral).

top of page

12. Superoxide Dismutase_Tempol

Q4699 Awonuga,A.O., Fletcher,N.M., Saed,M.G., Nusrat,O., Abusamaan,M.S., Belotte,J., Diamond,M.P., Saed,G.M., Awonuga,A.O. THE IN-VIVO EFFECTS OF SUPEROXIDE DISMUTASE ON THE INCIDENCE AND SEVERITY OF POST-OPERATIVE ADHESION DEVELOPMENT 751. Fertility and Sterility 2014; 102(--):E73-E73. >>> Superoxide dismutase; Saline; IP; Rat; 3 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley);.

Q4451 Ho,Y.H., Lin,Y.T., Wu,C.W.J., Chao,Y.M., Chang,A.Y.W., Chan,J.Y.H., Chan,J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

Q4343 Cao,W., Li,A.Q., Wang,L.L., Zhou,Z.M., Su,Z.X., Bin,W., Wilcox,C.S., Hou,F.F., Hou,F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. Journal of the American Society of Nephrology 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

Q4181 Wu,K.L.H., Chao,Y.M., Tsay,S.J., Chen,C.H., Chan,S.H.H., Dovinova,I., Chan,J.Y.H., Chan,J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

Q3661 Su,Q., Qin,D.N., Wang,F.X., Ren,J., Li,H.B., Zhang,M., Yang,Q., Miao,Y.W., Yu,X.J., Qi,J., Zhu,Z.M., Zhu,G.Q., Kang,Y.M., Qin,D.N. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 276(--):115-120. >>> Tempol; angiotensin II; CSF, artificial; saline, sterile; CSF/CNS (paraventricular nuclei); Rat; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 250-275g); functionality of mp verified by increase bp; tissue perfusion (paraventricular nucleus); immunology; "The success rate of bilateral microinjection and vein infusion is respectively 65% and 78%." pg 116; bp measured using tail-cuff;.

Q2183 Knight,S.F., Kundu,K., Joseph,G., Dikalov,S., Weiss,D., Murthy,N., Taylor,W.R. Folate Receptor-Targeted Antioxidant Therapy Ameliorates Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology 2012; 23(-5-):793-800. >>> Tempol; Saline; folate; IV (jugular); Mice; 48 hours; Controls received mp w/ vehicle; animal info (male, C57BL/6, 11 wks old); ischemia (renal); 7-day pump used; post op. care (buprenorphine in saline).

Q2125 Ozumi,K., Sudhahar,V., Kim,H.W., Chen,G.F., Kohno,T., Finney,L., Vogt,S., McKinney,R.D., Ushio-Fukai,M., Fukai,T. Role of Copper Transport Protein Antioxidant 1 in Angiotensin II-Induced Hypertension A Key Regulator of Extracellular Superoxide Dismutase. Hypertension 2012; 60(-2-):476-U487. >>> Angiotensin II; Tempol; Saline; SC; Mice; 2002; 7 days; Controls received mp w/ vehicle; animal info (Atox1 -/-, 3 mo old); blood pressure measured via tail cuff.

Q1904 Fujita,M., Ando,K., Kawarazaki,H., Kawarasaki,C., Muraoka,K., Ohtsu,H., Shimizu,H., Fujita,T. Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced Chronic Kidney Disease. Hypertension 2012; 59(-1-):105-U259. >>> Tempol; CSF, artificial; CSF/CNS; IP; Rat; 2002; 4 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 3 wks old); pumps replaced after 2 week; cannula placement verified by ICV injection of Evans Blue dye after euthanization.

Q1866 Loinard,C., Zouggari,Y., Rueda,P., Ramkhelawon,B., Cochain,C., Vilar,J., Recalde,A., Richart,A., Charue,D., Duriez,M., Mori,M., renzana-Seisdedos,F., Levy,B.I., Heymes,C., Silvestre,J.S. C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression. Circulation 2012; 125(-8-):1014-U126. >>> Tempol; Mice; 2002; ; Controls received mp w/ saline; animal info (CHOP-10 deficient, wt, 28 g, 8 wks old); ischemia.

Q1702 Willett,N.J., Kundu,K., Knight,S.F., Dikalov,S., Murthy,N., Taylor,W.R. Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress. ANTIOXIDANTS&REDOX SIGNALING 2011; 15(-5-):1369-1378. >>> Tempol; ebselen; DMSO; saline; SC; IV (jugular); Mice; 2ML1; 1007D; 4 days; Animal info (male, 11-13 wks old, C57BL/6, P47 phox -/-); 50% DMSO used.

Q1156 Kappers,M.H.W., Smedts,F.M.M., Horn,T., van Esch,J.H.M., Sleijfer,S., Leijten,F., Wesseling,S., Strevens,H., Danser,A.H.J., van den Meiracker,A.H. The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System. Hypertension 2011; 58(-2-):295-U351. >>> Tempol; SC; Rat; 2ML2; 8 days; Animal info (male, Wistar, Kyoto, 280-300 g).

P9880 Wu,K.L.H., Hsu,C., Chan,J.Y.H. Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):965-977. >>> Methylisothiourea, S-; PTIO, carboxy-; Coenzyme Q10; tempol; FeTMPyP; furosemide; PJ-34; CSF, artificial; sesame oil; CSF/CNS (spinal cord); Rat; 1003D; 3 days; Controls received mp w/ vehicle; multiple pumps per animal (2); post op. care (procraine penicillin); adult, male, specific pathogen free, 200-250 g.); spinal cord injury; PE-10 catheter used; PTIO is a NO trapping agent; enzyme inhibitor PJ-34 is poly(ADP-ribose) polymerase PARP inhibitor.

P9759 Ge,N.N., Brodie,H.A., Tinling,S.P. Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase. OTOLOGY&NEUROTOLOGY 2008; 29(-8-):1061-1067. >>> Superoxide dismutase; CSF, artificial; CSF/CNS (intrathecal); Gerbil; 1002; 14 days; Controls received IM injections of SOD; half-life (p.1065) 40 hours; animal info (8 wks old, male, Mongolian); dental cement used to hold tubing in place; silastic tubing used; image of surgical placement of pumps fig.2., fig. 4.

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions; bilateral infusion;.

P9252 Qin,Z.Y., Gongora,M.C., Ozumi,K., Itoh,S., Akram,K., Ushio-Fukai,M., Harrison,D.G., Fukai,T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; 14 days; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

P9217 Silva,G.B., Garvin,J.L. Angiotensin II-Dependent Hypertension Increases Na Transport-Related Oxygen Consumption by the Thick Ascending Limb. Hypertension 2008; 52(-6-):1091-1098. >>> Angiotensin II; dye, coomassie blue R250; G86976; tempol; SC; kidney (outer medulla); Rat; 1007D; 4, 7 days; Controls received mp w/ vehicle; tissue perfusion (kidney); functionality of mp verified by residual volume and dye infusion; enzyme inhibitor (PKC a/b); cardiovascular; antihypertensive; peptide; cyanoacrylate adhesive; animal info (Sprague Dawley, 7 wks old, 200-250 g.); catheter fenestrated in one side 10 mm from the tip.

P9146 Zhang,Z.H., Yu,Y., Kang,Y.M., Wei,S.G., Felder,R.B. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1067-H1074. >>> Aldosterone; RU-28318; Tempol; losartan; CSF, artificial; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague Dawley, 250-300 g.); silastic tubing used; dental cement used.

P9076 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons. Circulation Research 2008; 103(-2-):186-193. >>> Tempol; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; animal info (New Zealand, White, 3.5-4.3 kg.); 19 gauge cannula used.

P9074 Xue,B.J., Zhao,Y.Z., Johnson,A.K., Hay,M. Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1025-H1032. >>> Tempol; estradiol, 17B-; ICI-182780; SC; CSF/CNS; Mice; 1002; 7, 14 days; ALZET brain infusion kit used; peptides; animal info (male, C57BL/6, 12-16 wks old); location of cannula was verified histologically post mortem.

P9053 Kang,Y.M., Ma,Y., Elks,C., Zheng,J.P., Yang,Z.M., Francis,J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappa B. Cardiovascular Research 2008; 79(-4-):671-678. >>> Losartan; SN50; tempol; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-275 g.); pumps were primed in 0.9% saline for 24 hours; SN50 is a synthetic protein.

P7696 Wu,D.C., Teismann,P., Tieu,K., Vila,M., Jackson-Lewis,V., Ischiropoulos,H., Przedborski,S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc.Natl.Acad.Sci.U.S.A 2003/5/13; 100(-10-):6145-6150. >>> Tempol; CSF/CNS (striatum); Mice; 7 days; Neurodegenerative (Parkinson's disease).

P7413 Welch,W.J., Mendonca,M., Blau,J., Karber,A., Dennehy,K., Patel,K., Lao,Y.S., Jose,P.A., Wilcox,C.S. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney International 2005; 68(-1-):179-187. >>> Tempol; NaCl; SC; Rat; 2002; ; Controls received mp w/ vehicle; cardiovascular; animal info (male, wistar-kyoto, 210-300 g).

P7123 Kimura,Y., Hirooka,Y., Sagara,Y., Ito,K., Kishi,T., Shimokawa,H., Takeshita,A., Sunagawa,K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circulation Research 2005; 96(-2-):252-260. >>> Tempol; CSF, artificial; CSF/CNS (cisterna); Rat; 1002; 1 week; Controls received mp w/ vehicle; comparison of CSF/CNS microinjections vs. mp; cardiovascular.

P7099 Benn,S.C., Ay,I., Bastia,E., Chian,R.J., Celia,S.A., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of Neurochemistry 2005; 95(-4-):1118-1131. >>> Toxin, tetanus fragment C; tempol, toxin tetanus fragment C; CSF/CNS; Mice; 2001; 7 days; Stability verified by incubation at 37C for 7 days; brain tissue distribution; post op. care (bupivicaine and betadine in wound); animal info (C57BL/6, male, 25-30 g); dental cement used for cannula adhesion, agent also know as TTC; compounds were also distributed to further brain sites such as the hypothalamus and the thalamus.

P7013 Welch,W.J., Blau,J., Xie,H., Chabrashvili,T., Wilcox,C.S. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H22-H28. >>> Angiotensin II; tempol; Sodium chloride; SC; Rat; 2002; 12-13 days; Controls received mp w/ vehicle; no stress (pg. H23); cardiovascular; antihypertensive; peptides; multiple pumps per animal (2).

P6143 Kawada,N., Imai,E., Karber,A., Welch,W.J., Wilcox,C.S. A mouse model of angiotensin II slow pressor response: Role of oxidati ve stress. Journal of the American Society of Nephrology 2002; 13(-12-):2860-2868. >>> Angiotensin II; tempol; Saline; SC; Mice; 1002; 14 days; Blood pressure taken; dose-response (p. 2862); cardiovascular; peptides.

P6059 Sedeek,M.H., Llinas,M.T., Drummond,H., Fortepiani,L., Abram,S.R., Alexander,B.T., Reckelhoff,J.F., Granger,J.P. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 2003; 42(-4-):806-810. >>> Endothelin-1; tempol; IV (jugular); Rat; 2002; 9 days; Peptides.

P5848 Gariboldi,M.B., Ravizza,R., Petterino,C., Castagnaro,M., Finocchiaro,G., Monti,E. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol - a potential new therapeutic agent for gliomas. European Journal of Cancer 2003; 39(-6-):829-837. >>> Tempol; Saline, sterile; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; comparison of IP injections vs. mp; adverse reaction: (see pg. 835) precipitation in pump; cancer (glioma); antioxidant; tempol (TPL) or (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxy) or superoxide dismutase, mimetic is a stable nitroxide free radical; "375 mg/ml concentration was highest achievable TPL concentration, when this limit was exceeded, TPL precipitation occurred, impairing drug flow from the pump...".

P5654 Welch,W.J., Mendonca,M., Aslam,S., Wilcox,C.S. Roles of oxidative stress and AT(1) receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Hypertension 2003; 41(-3-):692-696. >>> Tempol; Rat; 2 weeks; Antihypertensive; also refered as superoxide dismutase, mimetic.

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3115 Truelove,D., Shuaib,A., Ijaz,S., Richardson,S., Kalra,J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem.Res. 1994; 19(-6-):665-671. >>> Tempol; catalase; CSF/CNS; Gerbil; 1007D; 7 days; Controls received mp with saline; agents given separately and together; ischemia (cerebral).

P3114 Truelove,D., Shuaib,A., Ijaz,S., Ishaqzay,R., Kalra,J. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils. Free Rad.Biol.Med. 1994; 17(-5-):445-450. >>> Superoxide dismutase-PEG; Saline; CSF/CNS; gerbil; 1007D; 6 days; controls received mp with vehicle; ischemia (cerebral).

P2520 Macdonald,R.L., Weir,B.K.A., Runzer,T.D., Grace,M.G.A., Poznansky,M.J. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30(-4-):529-539. >>> Catalase; tempol; CSF/CNS (spinal cord, intrathecal); monkey; 2ML1; 7 days; controls received inactivated SOD and BSA; functionality of mp verified by measuring enzyme levels in CSF during infusion and testing agent released from pump in vitro for 7 days; stability verified by measuring activity of enzymes released from pumps in vitro over 7 days; daily CSF sampling performed using a subcutaneous Ommaya reservoir; authors report no cases of catheter blockage or dislodgement.

P2438 Suzuki,S., Kanashiro,M., Hayashi,R., Amemiya,H. Rescue therapy for acute rejection using 15-deoxyspergualin (DSG) in combination with superoxide dismutase (SOD) on cardiac allografts in rats. Transplant.Int. 1992; 5(-Sup.1-):S547-S551. >>> Sodium oxide dismutase, recomb. human (tempol); Saline; IV (vena cava); rat; 2001; 8 days; dose-response (graph p. S550).

P1931 Hattori,T., Ito,M., Suzuki,Y. Changes in intra-renal scavenging enzymes activities of the reactive oxygen species in experimental glomerulo-nephritis and nephrosis in rats. Nippon Jinzo Gakkai Shi 1991; 33(-2-):191-199. >>> Glutathione peroxidase; Catalase; tempol; rat; no duration posted; Japanese with English abstract.

P1741 Mossman,B.T., Marsh,J.P., Sesko,A., Hill,S., Shatos,M.A., Doherty,J., Petruska,J., Adler,K.B., Hemenway,D., Mickey,R., Vacek,P., Kagan,E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am.Rev.Respir.Dis. 1990; 141(--):1266-1271. >>> Catalase; tempol; PBS; SC; rat; 2ML4; 10, 20 days; functionality of mp verified by serum catalase; PEG-conjugated enzymes; antioxidants; stability of enzymes questioned beyond 20 days.

P1476 Teixeira,A.A., Azevedo,I., Branco,D., Rodrigues-Pereira,E., Osswald,W. Sympathetic denervation caused by long-term noradrenaline infusions; prevention by desipramine and superoxide dismutase. Br.J.Pharmacol. 1989; 97(--):95-102. >>> Desipramine HCl; Norepinephrine; tempol; EDTA; Heparin; Saline; IV (saphenous); dog; 2ML1; 5 days; dose-response; implanted sc above the knee; functionality of mp verified by visual inspection of sectioned pump and by serum levels; tissue perfusion; animal info (m, 9-15 kg); 5000 Units of heparin.

P0153 Gold,G., Manning,M., Heldt,A., Nowlain,R., Pettit,J.R., Grodsky,G.M. Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase. Diabetes 1981; 30(--):634-638. >>> Tempol; Saline; SC; mice; 7 days; comparison of iv injection vs. infusion.

top of page

13. Tolmetin

P2007 Rodgers,K.E., Girgis,W., diZerega,G.S. Effect of tolmetin sodium dihydrate on adhesion formation by intraperitoneal administration of antineoplastic agents. Cancer Chemother.Pharmacol. 1992; 29(--):248-251. >>> Doxorubicin HCl; Mitoxantrone; Tolmetin sodium; Bleomycin; Cisplatin; Methotrexate; PBS; IP; rat; 2ML1; 7 days; Antibiotic; cancer; no stress (see p249).

top of page

14. Zomepirac

S0199 Cowan,A., Tortella,F.C., Gmerek,D.E. EEG and behavioral studies with zomepirac sodium in rats. Pain 1981; 11(-1-):194-. >>> Zomepirac, sodium; Water; CSF/CNS; SC; rat; 2001; no duration posted; 7 days icv, 3 days sc.

top of page

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying ...

“However, the s.c. mini-osmotic pump delivery of recombinant leptin raised circulating leptin into the physiological range (Table 2). These data confirmed the effectiveness of the s.c. infusion of leptin at 0.1 mg/day in restoring serum leptin levels.” Zhang et al. Journal of Endocrinology 2002; 174:455-461.