References on the Administration of Nonsteroidal Anti-inflammatory Drugs Using ALZET® Osmotic Pumps

1. Acetylsalicylic Acid

P8555 Adamek,A., Hu,K., Bayer,B., Wagner,H., Ertl,G., Bauersachs,J., Frantz,S. High dose aspirin and left ventricular remodeling after myocardial infarction. Basic Research In Cardiology 2007; 102(-4-):334-340. >>> Acetylsalicylic acid, lysine; Saline; SC; Mice; 2002; 4 weeks; Controls received mp w/ placebo; functionality of mp verified by serum salicylate concentrations; pumps replaced after 2 weeks; cardiovascular; ischemia (cardiac); animal info (female, C57BL/6, 8-12 weeks old, 20-25 grams); MI induced by coronary artery ligation.

P4829 Yuan,M, Konstantopoulos,N, Lee,J, Hansen,L, Li,Z.-W, Karin,M, Shoelson,S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkb. Science 2001; 293(--):1673-1677. >>> Acetylsalicylic acid; salicylate, sodium; SC; Rat; mice; 2002; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; 2ML2 used in rats, 2002 used in mice; acetylsalicylic acid also called aspirin: dose was 120 mg/kg/day; diabetes (type II).

P0455 Oshima,T., McCluskey,E.R., Honda,A., Needleman,P. Pharmacological manipulation of canine cyclooxygenase and thromboxane synthetase in vivo: differential renal and platelet recovery rates. J.Pharmacol.Exp.Ther. 1984; 229(-2-):598-602. >>> Acetylsalicylic acid; DMSO; Saline; IV (superficial cervical vein); dog; 2ML1; 3 days; pumps primed for 4 hrs. before implant; used prefilled catheter in vein; greater solubility of ASA in DMSO allowed greater concentration in smaller total volume.

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2. Diclofenac

P5994 Murase,T., Tian,Y., Fang,X.Y., Verbalis,J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; 5 days; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

P3383 Risto,O., Wahlstrom,O., Abdiu,A. The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats. Int.Orthopaedics (SICOT) 1995; 19(--):392-395. >>> Diclofenac; NaCl; bone; rat; 2001;

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3. Flurbiprofen

Q0222 Campanella,C., Jamali,F. Influence of prolonged exposure of a short half life non-steroidal anti-inflammatory drugs on gastrointestinal safety. INFLAMMOPHARMACOLOGY 2009; 17(-4-):205-210. >>> Flurbiprofen; PEG 400; IP; Rat; 2002; 7 days; Comparison of IP injections vs. mp; stability verified in vitro test for 14 days; animal info (male, Sprague Dawley, adult, 300-350 g.); "There was no significant difference between the two i.p. groups in the post-mortem plasma R or S-flurbiprofen concentration or in the percent of the dose excreted as glucoronidated flurbiprofen in urine on days 1 and 7" pg 207.

P7625 Peretto,I., Radaelli,S., Parini,C., Zandi,M., Raveglia,L.F., Dondio,G., Fontanella,L., Misiano,P., Bigogno,C., Rizzi,A., Riccardi,B., Biscaioli,M., Marchetti,S., Puccini,P., Catinella,S., Rondelli,I., Cenacchi,V., Bolzoni,P.T., Caruso,P., Villetti,G., Facchinetti,F., Del Giudice,E., Moretto,N., Imbimbo,B.P. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors beta-amyloid (1-42) secretion. Journal of Medicinal Chemistry 2005; 48(-18-):5705-5720. >>> Flurbiprofen analogues; flurbiprofen; SC; Rat; 2001; 4-7 days; Dose-response; neurodegenerative (Alzheimer's disease); cassette dosing technology: 2-6 different analog compounds administered simultaneously to one animal.

P1533 Offenbacher,S., Odle,B.M., Braswell,L.D., Johnson,H.G., Hall,C.M., McClure,H., Orkin,J.L., Strobert,E.A., Green,M.D. Changes in cyclooxygenase metabolites in experimental periodontitis in macaca mulatta. J.Periodontal Res. 1989; 24(--):63-74. >>> Flurbiprofen; SC; monkey; 2ML2; 2ML4; 6, 12 months; controls received no drugs or sham pumps; multiple pumps per animal (2) (simultaneously); pumps replaced every 2 weeks or monthly; long-term study; one animal removed from study due to a 'secondary infection caused by a cage-pressure abrasion at the site of the s.c..

P1208 Offenbacher,S., Braswell,L.D., Loos,A.S., Johnson,H.G., Hall,C.M., McClure,H., Orkin,J.L., Strobert,E.A., Green,M.D., Odle,B.M. Effects of flurbiprofen on the progression of periodontitis in macaca mulatta. J.Periodontal Res. 1987; 22(-6-):473-481. >>> Flurbiprofen; Tris buffer; SC; monkey; 2ML2; 2ML4; 6 months; controls received mp w/ tris buffer; dose-response (table); 2 doses of agent infused; high dosage group received 2 pumps (2ML2); pumps replaced every 4 weeks for 2ML4, 2 weeks for 2ML2; long-term study.

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4. Ibuprofen

Q4741 Sharp,K.G., Yee,K.M., Stiles,T.L., Aguilar,R.M., Steward,O. A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. Experimental Neurology 2013; 248(--):321-337. >>> Ibuprofen; Saline; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 9-10 weeks old); spinal cord injury; post op. care (bladders expressed BID); behavioral testing (hindlimb locomotor function; gridwalk task, footprint analysis, girdle test, plantar von frey); immunology; pumps primed primed for 16h in 37C saline;.

Q4703 Benadiba,M., Costa,I.D., Santos,R.L.S.R., Serachi,F.O., Silva,D.D., Colquhoun,A., Colquhoun,A. Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru(2)Cl(Ibp)(4)], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo 1993. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 2014; 19(--):1025-1035. >>> Diruthenium-ibuprofen; Ethanol; CSF, artificial; CSF/CNS (intratumoral); Rat; 2002; 14 days; Animal info (female, Wistar, 250-350g); ALZET brain infusion kit used; 15% ethanol used; comparison of injection vs mp; cancer (glioma); tissue perfusion (intratumoral, glioma);â·Using the orthotopic C6 model the effects of either chronic 14-day treatment by intra-peritoneal injection of chronic 14-day intra-tumour infusion by an Alzet osmotic pump attached to a brain infusion cannula were tested. Tumour growth was reduced by both routes of administration with the osmotic pump appearing to be the less harmful route in terms of haematological responses.âpg 1033; Diruthenium-Ibuprofen aka RuIbp;.

Q3526 Jurk,D., Wilson,C., Passos,J.F., Oakley,F., Correia-Melo,C., Greaves,L., Saretzki,G., Fox,C., Lawless,C., Anderson,R., Hewitt,G., Pender,S.L.F., Fullard,N., Nelson,G., Mann,J., van de Sluis,B., Mann,D.A., von Zglinicki,T., von Zglinicki,T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications 2014; 5(--):U235-U248. >>> Ibuprofen; PEG; DMSO; SC; Mice; 2004; 8 weeks; Animal info (male, nfkb1 -/-, 24 weeks old); pumps replaced every 28 days; 50% DMSO used; 50% PEG used; behavioral testing (tightrope test); used 7mm wound clips;.

Q1221 Madura,T., Tomita,K., Terenghi,G. Ibuprofen improves functional outcome after axotomy and immediate repair in the peripheral nervous system. Journal of Plastic Reconstructive and Aesthetic Surgery 2011; 64(-12-):1641-1646. >>> Ibuprofen; PBS; SC; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; animal info (female, Wistar, 200 g); stress/adverse reaction: "pressure necrosis" (see pg. 1643).

Q0207 Van Dam,D., Coen,K., De Deyn,P.P. Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. JOURNAL OF PSYCHOPHARMACOLOGY 2010; 24(-3-):383-388. >>> Ibuprofen; PEG 300; water, ultrapure; SC; Mice; 2004; 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced after 4 weeks; animal info (6 wks old, male, APP23); neurodegenerative (Alzheimer's Disease).

P9697 Wang,X.X., Budel,S., Baughman,K., Gould,G., Song,K.H., Strittmatter,S.M. Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth. Journal of Neurotrauma 2009; 26(-1-):81-95. >>> Ibuprofen; naproxen; PBS; SC; Rat; mice; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 11-12 wks old, 250-270 g., female, C57BL/6, 8-9 wks old, 20 g.); spinal cord injury; behavioral testing (BBB locomotor scale, Basso mouse scale).

P5919 Wagner,C., Vitzthum,H., Castrop,H., Schumacher,K., Bucher,M., Albertin,S., Coffman,T.M., Arendshorst,W.J., Kurtz,A. Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003; 447(-2-):214-222. >>> Bumetanide; ibuprofen; SC; Mice; 1007D; 7 days.

P1145 Orita,H., Girgis,W., diZerega,G.S. Prevention of postsurgical peritoneal adhesion formation by intraperitoneal administration of ibuprofen. Drug Dev.Res. 1987; 10(--):97-105. >>> Ibuprofen; PBS; Ringer's solution, lactated; IP; rabbit; 2002; 2ML1; 7, 14 days; controls rec'd mp w/ vehicle; mp connected to cath.; 2 exp.; varying doses of agent; ip + extraperitoneal pump placement; comparison of inject. vs. mp infusion; stress/adverse react. (fibrinous tissue).

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5. Indomethacin

Q4542 Na,Y.R., Yoon,Y.N., Son,D., Jung,D., Gu,G.J., Seok,S.H., Seok,S.H. Consistent Inhibition of Cyclooxygenase Drives Macrophages towards the Inflammatory Phenotype. PLoS One 2015; 10(--):U1730-U1742. >>> NA-398; SC-560; indomethacin; DMSO; SC; Mice; 30 days; Controls received mp w/ vehicle; animal info (female, BALB/c); immunology;.

P4819 Babin,M.C., Ricketts,K., Skvorak,J.P., Gazaway,M., Mitcheltree,L.W., Casillas,R.P. Systemic administration of candidate antivesicants to protect against topically applied suitor mustard in the mouse ear vesicant model (MEVM ).. Journal of Applied Toxicology 2000; 20(--):S141-S144. >>> Hydrocortisone; indomethacin; olvanil; PEG 200; SC; mice; 2 days; Controls received mp w/ vehicle; toxicology.

P4475 Zlatnik,M.G., Buhimschi,I, Chwalisz,K., Liao,Q.-P., Saade,G.R., Garfield,R.E. The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.. Am.J.Obstet.Gynecol. 1999/5; 180(-5-):1191-1195. >>> Iloprost; Cicaprost; L-NAME; Indomethacin; Saline;; SC;; rat (pregnant);; 2ML2;; 2 weeks;; controls received mp w/vehicle; comparison of SC injections vs. mp; cardiovascular; L-NAME is a synthase inhibitor;.

P4207 Shimoda,K., Nomura,M., Kato,M. Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on Sparfloxacin-induced phototoxicity in mice. Fundam.Appl.Toxicol. 1996; 31(--):133-140. >>> Catalase; Dimethyl sulfoxide; Dexamethasone; Indomethacin; Pyrilamine maleate; AA-861; Cimetidine; Phenidone; Ethanol; Saline; SC; mice; 1007D; 72 hours; all agents infused concomitantly in the same pump; preliminary study conducted to test solubility and toxicity for 5 days; enzyme inhibitors; toxicology.

P3986 Henke,P.K., Bergamini,T.M., Watson,A.L., Brittian,K.R., Powell,D.W., Peyton,J.C. Bacterial products primarily mediate fibroblast inhibition in biomaterial infection. J.Surg.Res. 1998; 74(--):17-22. >>> Antibody, anti-interferon gamma; Antibody, indomethacin; Antibody, anti-TNFa; Antibody, interleukin 1 alpha; PBS, sterile; ETOH; Indomethacin; SC; mice; 1007D; 7 days; immunology; pump implanted next to Dacron graft; peptides.

P3918 Henke,P.K., Bergamini,T.M., Brittian,K.R., Polk Jr,H.C. Prostaglandin E2 modulates monocyte MHC-II (Ia) suppression in biomaterial infection. J.Surg.Res. 1997; 69(--):372-378. >>> Indomethacin; Antibody, anti-IL-1a; Antibody, anti-TNFa; PBS; ETOH; SC; Mice; 7 days; Controls received mp w/ vehicle; immunology.

P3614 Fernandez,M., Garcia-Pagan,J.C., Casadevall,M., Mourelle,M.I., Pique,J.M., Bosch,J., Rodes,J. Acute and chronic cyclooxygenase blockade in portal-hypertensive rats: influence on nitric oxide biosynthesis. Gastroenterol. 1996; 110(--):1529-1535. >>> Indomethacin; Sodium carbonate; SC; rat; 2ML2; 7 days; sonication used to suspend indomethacin.

P2852 Sakamoto,T., Soriano,D., Nassaralla,J., Murphy,T.L., Oganesian,A., Spec,C., Hinton,D.R., Ryan,S.J. Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Arch Ophthalmol. 1995; 113(--):222-226. >>> Indomethacin; GBR buffer; Cyclodextrin, B-; Eye (vitreous); monkey; 2ML2; 14 days; control eyes received mp with vehicles; enzyme inhibitor; indomethacin is a cyclooxygenase (COX) inhibitor; detailed description of vitreal cannula implantation; empty pump implanted at time of cannula implantation to allow 1-month recovery period; beta-cyclodextrin used as a carrier molecule; some monkeys served both as control and drug treatment group (different treatment in each eye); a vitreous opacity appeared in some eyes during infusion but disappeared after the pump was disconnected.

P1204 Schlegel,W., Doren,M., Cirkel,U., Schneider,H.P.G. Effect of continuous intrauterine administration of prostaglandin F2alpha and indomethacin on fertilization of rabbits. Horm.Metab.Res. 1986; 18(--):457-461. >>> Indomethacin; Prostaglandin F2a; HCl; Sodium hydroxide; Saline; intrauterine; rabbit; 2002; 11 days; controls received mp w/ vehicle; separate and simultaneous infusion of agents; comparison of agents effects; NaOH, HCl and saline were used in combination as the vehicle for indomethacin; many different exp.; tissue perfusion (cornua of uterus).

P1031 Doktorcik,P.E., Kennedy,T.G. 6-Keto-prostaglandin E1 and the decidual cell reaction in rats. Prostaglandins 1986; 32(-5-):679-689. >>> Indomethacin; Prostaglandin E1; Prostaglandin E2; Ethanol; Gelatin; PBS; intrauterine; rat; 2001; 5 days; mp w/vehicle; dose-response; indomethacin infused with prostaglandin E1 in one group and with prostaglandin E2 in another group; tissue perfusion (uterus).

P0794 Kennedy,T.G. Intrauterine infusion of prostaglandins and decidualization in rats with uteri differentially sensitized for the decidual cell reaction. Biol.Reprod. 1986; 34(-2-):327-335. >>> Indomethacin; Prostaglandin E2; Prostaglandin F2a; Ethanol; Gelatin; PBS; intrauterine; rat; 2001; 5 days; replacement therapy (ovariectomy); controls received mp w/ vehicle; estradiol and progesterone injected sc w/ mp PG infusion; vehicle contained indomethacin to reduce PG synthesis; tissue perfusion (uterus).

P0739 Kennedy,T.G. Evidence for the involvement of prostaglandins throughout the decidual cell reaction in the rat. Biol.Reprod. 1985; 33(--):140-146. >>> Indomethacin; Prostaglandin E2; Prostaglandin F2a; Ethanol; PBS; intrauterine; rat; 2001; 5 days; replacement therapy (ovariectomy); pumps primed overnight in saline; sc adminis. of agents in comb. w/mp infusion; separate and simultaneous infusion of agents; tissue perfusion (uterus).

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6. Ketorolac

P8822 Scarlett,J.M., Jobst,E.E., Enriori,P.J., Bowe,D.D., Batra,A.K., Grant,W.F., Cowley,M.A., Marks,D.L. Regulation of central melanocortin signaling by interleukin-1beta. Endocrinology 2007; 148(-9-):4217-4225. >>> Ketorolac; Saline, sterile; SC; Mice; 1007D; 2 days; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 4-5 wks old).

P5091 Southall,M.D., Bolyard,L.A., Vasko,M.R. Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE(2)-mediated sensitization of rat sensory neurons. Pain 2002; 96(--):285-296. >>> Ketorolac tromethamine; Saline; CSF/CNS (intrathecal); rat; 2001; 48 hours; controls received mp w/ vehicle; ketorolac is an NSAID sold as Toradol; cannula patency verfied by saline injection.

P4204 Shufflebarger,J.V., Doyle,J., Roth,T., Maguire,K., Rothkopf,D.M. The effect of ketorolac on microvascular thrombosis in an experimental rabbit model. Plast.Reconstr.Surg. 1996; 98(--):140-145. >>> Ketorolac; IV (jugular); rabbit; 2ML1; 7 days; controls received mp w/saline; functionality of mp verified by residual volume; comparison of i.m. injections vs. mp; ketorolac also called Toradol; NSAID.

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7. L-NAME

6449 Hofseth, L.J., Hussain, S.P., Wogan, G.N., Harris, C.C. Nitric oxide in cancer and chemoprevention. Free Radical Biology and Medicine 2003; 34(-8-):955-968. >>> L-NAME; Mice; Cancer (breast); pg. 958, Table 2, ref. 218.

4552 Li, J, Billiar, T.R. Nitric oxide IV. determination of nitric oxide protection and toxicity in liver. Am. J. Physiol 1999; 276(--):G1069-G1073. >>> L-NMMA; L-NAME; Aminoguanidine; IV (hepatic portal);; rat;; nitric oxide synthase inhibitors;.

16141 Netti, V. A., Iovane, A. N., Vatrella, M. C., Zotta, E., Fellet, A. L., Balaszczuk, A. M. Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart. Biomed Pharmacother 2016; 81(--):225-34. >>> L-NAME; Saline; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 25-50 days old); cardiovascular; L-NAME solution prepared in laminar flow cabinet and used filter; Dose (4 mg/kg/day);.

15930 Pojoga, L. H., Yao, T. M., Opsasnick, L. A., Siddiqui, W. T., Reslan, O. M., Adler, G. K., Williams, G. H., Khalil, R. A. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther 2015; 355(-1-):32-47. >>> Angiotensin II; L-NAME; SC; animal info (male, cav-1 KO, 12 weeks old); AngII infused to induce cardiovascular injury; Dose (L-NAME 0.1 - 0.2 mg/mL; AngII 0.7-2.8 mg/kg/day);.

15097 Tain, Y.L., Huang, L.T., Chan, J.Y.H., Lee, C.T., Tain, Y.L. Transcriptome Analysis in Rat Kidneys: Importance of Genes Involved in Programmed Hypertension. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015; 16(--):4744-4758. >>> L-NAME; SC; Rat (pregnant); Controls received mp w/ saline, iso-osmotic; animal info (female, Sprague Dawley); teratology; cardiovascular; bp measured using tail cuff;.

14424 Tain, Y.L., Huang, L.T., Lee, C.T., Chan, J.Y.H., Hsu, C.N., Tain, Y.L. Maternal Citrulline Supplementation Prevents Prenatal N(G)-Nitro-L-Arginine-Methyl Ester (L-NAME)-Induced Programmed Hypertension in Rats. Biology of Reproduction 2015; 92(--):U27-U33. >>> L-NAME; SC; Rat (pregnant); Animal info (female, Sprague Dawley, 10 weeks old); teratology; cardiovascular;.

14423 Tain, Y.L., Lee, C.T., Huang, L.T., Tain, Y.L. Long-Term Effects of Maternal Citrulline Supplementation on Renal Transcriptome Prevention of Nitric Oxide Depletion-Related Programmed Hypertension: The Impact of Gene-Nutrient Interactions. International Journal of Molecular Sciences 2014; 15(--):23255-23268. >>> L-NAME; SC; Rat (pregnant); Controls received mp w/ saline; animal info (female, Sprague Dawley, 10 weeks old); teratology; cardiovascular;.

13570 Zana-Taieb, E., Butruille, L., Franco-Montoya, M.L., Lopez, E., Vernier, F., Grandvuillemin, I., Evain-Brion, D., Deruelle, P., Baud, O., Delacourt, C., Jarreau, P.H. Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs: Morphometric and Gene Expression Analysis. PLoS One 2013; 8(-11-):U35-U45. >>> L-NAME; Saline; SC; Rat (pregnant); Controls received high protein diet; animal info (Female, Sprague Dawley); teratology.

13402 Kurabayashi, A., Kakinuma, Y., Morita, T., Inoue, K., Sato, T., Furihata, M. Conditional VHL Gene Deletion Causes Hypoglycemic Death Associated with Disproportionately Increased Glucose Uptake by Hepatocytes through an Upregulated IGF-I Receptor. PLoS One 2013; 8(-7-):U1405-U1415. >>> L-NAME; Insulin-like growth factor 1 receptor; Saline; acetic acid; SC; Mice; Controls received mp w/ vehicle; animal info (VHL-KO); 25% acetic acid used; immunology.

13324 Abe, H., Ishikawa, W., Kushima, T., Nishimura, T., Mori, C., Onuki, A., Suzuki, T., Ishii, Y., Kansaku, N., Miyazaki, Y., Tanaka, K., Morita, H., Takizawa, T. Nitric Oxide Induces Vascular Endothelial Growth Factor Expression in the Rat Placenta in Vivo and in Vitro. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2013; 77(-5-):971-976. >>> L-NAME; SC; Rat (pregnant); 2001D; Animal info (Crj Wistar); enzyme inhibitor (NOS, nitric oxide).

12904 Butruille, L., Mayeur, S., Moitrot, E., Storme, L., Knauf, C., Lesage, J., Deruelle, P. Maternal hypertension induced by NO blockade does not program adult metabolic diseases in growth-restricted rat fetuses. METABOLISM-CLINICAL AND EXPERIMENTAL 2013; 62(-3-):442-445. >>> L-NAME; SC; Rat (pregnant); 2ML1; Control animals received mp w/ saline; animal info (Wistar Han, female, E17).

12482 Hale, S.A., Weger, L., Mandala, M., Osol, G. Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition. American Journal of Physiology-Heart and Circulatory Physiology 2011; 301(-4-):H1266-H1275. >>> L-NAME; SC; Rat (pregnant); Controls received mp w/ saline; animal info (Sprague Dawley, female).

12479 Ivars, J., Butruille, L., Knauf, C., Bouckenooghe, T., Mayeur, S., Vieau, D., Valet, P., Deruelle, P., Lesage, J. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat. Peptides 2012; 35(-1-):136-138. >>> L-NAME; SC; Rat (pregnant); Animal info (Wistar, female, E17); enzyme inhibitor (nitric oxide synthase, NOS);.

12373 Butruille, L., Mayeur, S., Duparc, T., Knauf, C., Moitrot, E., Fajardy, I., Valet, P., Storme, L., Deruelle, P., Lesage, J. Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat. European Journal of Pharmacology 2012; 689(-1-3-):278-284. >>> L-NAME; fasudil; SC; Rat (pregnant); Controls received mp w/ normal saline; animal info (Wistar Han, 200-250 g, E14, female); enzyme inhibitor (nitric oxide synthase, NOS, Rho-kinase, ROCK); one group contained mixture of fasudil and L-NAME; teratology.

11872 Neerhof, M.G., Synowiec, S., Khan, S., Thaete, L.G. Impact of Endothelin A Receptor Antagonist Selectivity in Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat. HYPERTENSION IN PREGNANCY 2010; 29(-3-):284-293. >>> FR139317; L-NAME; A-127722; ABT-546; Saline; ethyl alcohol; propylene glycol; NaOH; SC; IV (jugular); Rat; 2ML1; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, female, 11-20 wks old, 225-250 g); FR139317 is a tripeptide with 8000-fold selectivity for ETA23; peptides; multiple pumps used (2); enzyme inhibitor (NOS, nitric oxide synthase); ABT-546 is a nonpeptide ETA antagonist.

11848 Chung, E., Zelinski, L.M., Ohgami, Y., Shirachi, D.Y., Quock, R.M. Hyperbaric Oxygen Treatment Induces a 2-Phase Antinociceptive Response of Unusually Long Duration in Mice. JOURNAL OF PAIN 2010; 11(-9-):847-853. >>> L-NAME; naltrexone; Saline, physiological; CSF/CNS; Mice; 2001; Controls received mp w/ vehicle; animal info (NIH, Swiss, 18-22 g); ALZET brain infusion kit used; hyperbaric oxygen.

11674 Wroblewska-Seniuk, K., Nowicki, S., Le Bouguenec, C., Nowicki, B., Yallampalli, C. Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats. American Journal of Obstetrics and Gynecology 2011; 205(-1-):U242-U248. >>> L-NAME; Rat (pregnant); 2ML1; Controls received mp w/ vehicle; animal info (Sprague Dawley, female, timed-pregnant); enzyme inhibitor (NOS, nitric oxide synthase).

11609 Suzuki, T., Nagamatsu, C., Kushima, T., Miyakoshi, R., Tanaka, K., Morita, H., Sakaue, M., Takizawa, T. Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation. EXPERIMENTAL BIOLOGY AND MEDICINE 2010; 235(-4-):455-462. >>> L-NAME; SC; Rat (pregnant); 2ML1; Animal info (female, Crj, Wistar, 10-15 wks old); enzyme inhibitor (NOS).

11396 Hu, X.L., Atzler, D., Xu, X., Zhang, P., Guo, H.P., Lu, Z.B., Fassett, J., Schwedhelm, E., Boeger, R.H., Bache, R.J., Chen, Y.J. Dimethylarginine Dimethylaminohydrolase-1 Is the Critical Enzyme for Degrading the Cardiovascular Risk Factor Asymmetrical Dimethylarginine. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-7-):1540-U145. >>> L-NAME; SC; Mice; Wild type controls received mp w/ L-NAME; animal info (DDAH1 -/-).

11347 Gao, J., Zhang, H., Le, K.D., Chao, J., Gao, L. Activation of Central Angiotensin Type 2 Receptors Suppresses Norepinephrine Excretion and Blood Pressure in Conscious Rats. American Journal of Hypertension 2011; 24(-6-):724-730. >>> Compound 21; L-NAME; CSF, artificial; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 290-380 g); ALZET brain infusion kit used.

11191 Thaete, L.G., Neerhof, M.G. ENDOTHELIN AND BLOOD PRESSURE REGULATION IN THE FEMALE RAT: STUDIES INNORMAL PREGNANCY AND WITH NITRIC OXIDE SYNTHASE INHIBITION-INDUCEDHYPERTENSION. HYPERTENSION IN PREGNANCY 2011; 19(-2-):233-247. >>> A-127722; A-182086; A-192621; FR-139317; L-NAME; Ethyl alcohol; propylene glycol; NaOH; water; SC; IV (jugular); Rat (pregnant); rat; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley); multiple pumps per animal (2); wound clips used; 20% ethyl alcohol used;"It is likely that administration with the pumps resulted in more consistent drug levels..."pg 242.

11140 Mihout, F., Shweke, N., Bige, N., Jouanneau, C., Dussaule, J.C., Ronco, P., Chatziantoniou, C., Boffa, J.J. Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-beta 1 synthesis. Journal of Pathology 2011; 223(-1-):37-45. >>> L-NAME; dimethylarginine, asymmetric; SC; Mice; Controls received mp w/ iso-osmotic saline serum; animal info (23 g, male, SV129, 8 wks old, uninephrectomized); long-term study; enzyme inhibitor (nitric oxide synthase, NOS).

11051 Neerhof, M.G., Synowiec, S., Khan, S., Thaete, L.G. Pathophysiology of Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat. HYPERTENSION IN PREGNANCY 2011; 30(-1-):28-36. >>> L-NAME; ABT-546; Saline; ethyl alcohol; SC; Rat; 2ML1; Controls received mp w/ vehicle; animal info (female, male, Sprague-Dawley, 11-20 wks old, 225-250 g); multiple pumps per animal (2).

10221 Santhanam, L., Tuday, E.C., Webb, A.K., Dowzicky, P., Kim, J.H., Oh, Y.J., Sikka, G., Kuo, M., Halushka, M.K., Macgregor, A.M., Dunn, J., Gutbrod, S., Yin, D., Shoukas, A., Nyhan, D., Flavahan, N.A., Belkin, A.M., Berkowitz, D.E. Decreased S-Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness. Circulation Research 2010; 107(-1-):117-U243. >>> L-NAME; Cystamine; Mice; rat; Controls received mp w/vehicle; cardiovascular; enzyme inhibitor (NO synthase; transglutaminase); animal info (male, BL6129S wt, TG2 -/-, 3-5 months old; Fisher 344, 18-19 months old); pumps replaced every 4 weeks; long-term study.

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8. Lonazolac

S0361 Khalil,H., Vancaillie,T., Schlegel,W. The use of lonazolac (LON) and indomethacin (IND) and its influence on ovum transport (OT) in the rabbit. 7th International Congress of Endocrinology Abstracts, July 1-7, Quebec City, Canada, Excerpta Medica, Princeton 1984; (--):505-. >>> Lonazolac; Indomethacin; intrauterine; rabbit; 2ML1; no duration posted; comparison of single vaginal drug application vs. mp infusion; comparison of agents effects; tissue perfusion (uterus).

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9. Meclofenamate

1305 Sargent, E.L., Baughman, W.L., Novy, M.J., Stouffer, R.L. Intraluteal infusion of a prostaglandin synthesis inhibitor, sodium meclofenamate, causes premature luteolysis in rhesus monkeys. Endocrinology 1988; 123(-5-):2261-2269. >>> Meclofenamate, sodium; Saline; Water; intraovarian (corpus luteum); IV (jugular); monkey; 2ML1; stress/adverse reaction (cortisol and progesterone levels); tissue perfusion.

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10. Naproxen

Q4700 Baj-Rossi,C., Jost,T.R., Cavallini,A., Grassi,F., De Micheli,G., Carrara,S. Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor. BIOSENSORS&BIOELECTRONICS 2014; 53(--):283-287. >>> Naproxen; Methanol; In Vitro; 1002; 16 hours; Functionality of mp verified by naproxen levels measured with sensors;.

Q3710 Rosa,A.C., Pini,A., Lucarini,L., Lanzi,C., Veglia,E., Thurmond,R.L., Stark,H., Masini,E., Masini,E. Prevention of Bleomycin-Induced Lung Inflammation and Fibrosis in Mice by Naproxen and JNJ7777120 Treatment. Journal of Pharmacology and Experimental Therapeutics 2014; 351(--):308-316. >>> JNJ7777120; naproxen; SC; Mice; 1004; ; Control animals received mp w/ vehicle; animal info (male, C57BL/6, ~2 mo old, 25-30 g); infusion rate listed as 0.11 ul/hr; JNJ7777120 also known as (1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine), is a selective H4R antagonist; one group received combination of JNJ7777120 and naproxen.

P9697 Wang,X.X., Budel,S., Baughman,K., Gould,G., Song,K.H., Strittmatter,S.M. Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth. Journal of Neurotrauma 2009; 26(-1-):81-95. >>> Ibuprofen; naproxen; PBS; SC; Rat; mice; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 11-12 wks old, 250-270 g., female, C57BL/6, 8-9 wks old, 20 g.); spinal cord injury; behavioral testing (BBB locomotor scale, Basso mouse scale).

P1504 Chan,W.Y., Berezin,I., Daniel,E.E. Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats. Biol.Reprod. 1988; 39(--):1117-1128. >>> Naproxen, sodium; Saline; SC; rat (pregnant); 2001; 3 days; no comment posted.

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11. Superoxide Dismutase-PEG

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3114 Truelove,D., Shuaib,A., Ijaz,S., Ishaqzay,R., Kalra,J. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils. Free Rad.Biol.Med. 1994; 17(-5-):445-450. >>> Superoxide dismutase-PEG; Saline; CSF/CNS; gerbil; 1007D; 6 days; controls received mp with vehicle; ischemia (cerebral).

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12. Superoxide Dismutase_Tempol

Q4699 Awonuga,A.O., Fletcher,N.M., Saed,M.G., Nusrat,O., Abusamaan,M.S., Belotte,J., Diamond,M.P., Saed,G.M., Awonuga,A.O. THE IN-VIVO EFFECTS OF SUPEROXIDE DISMUTASE ON THE INCIDENCE AND SEVERITY OF POST-OPERATIVE ADHESION DEVELOPMENT 751. Fertility and Sterility 2014; 102(--):E73-E73. >>> Superoxide dismutase; Saline; IP; Rat; 3 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley);.

Q4451 Ho,Y.H., Lin,Y.T., Wu,C.W.J., Chao,Y.M., Chang,A.Y.W., Chan,J.Y.H., Chan,J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

Q4343 Cao,W., Li,A.Q., Wang,L.L., Zhou,Z.M., Su,Z.X., Bin,W., Wilcox,C.S., Hou,F.F., Hou,F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. Journal of the American Society of Nephrology 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

Q4181 Wu,K.L.H., Chao,Y.M., Tsay,S.J., Chen,C.H., Chan,S.H.H., Dovinova,I., Chan,J.Y.H., Chan,J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

Q3661 Su,Q., Qin,D.N., Wang,F.X., Ren,J., Li,H.B., Zhang,M., Yang,Q., Miao,Y.W., Yu,X.J., Qi,J., Zhu,Z.M., Zhu,G.Q., Kang,Y.M., Qin,D.N. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 276(--):115-120. >>> Tempol; angiotensin II; CSF, artificial; saline, sterile; CSF/CNS (paraventricular nuclei); Rat; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 250-275g); functionality of mp verified by increase bp; tissue perfusion (paraventricular nucleus); immunology; "The success rate of bilateral microinjection and vein infusion is respectively 65% and 78%." pg 116; bp measured using tail-cuff;.

Q2183 Knight,S.F., Kundu,K., Joseph,G., Dikalov,S., Weiss,D., Murthy,N., Taylor,W.R. Folate Receptor-Targeted Antioxidant Therapy Ameliorates Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology 2012; 23(-5-):793-800. >>> Tempol; Saline; folate; IV (jugular); Mice; 48 hours; Controls received mp w/ vehicle; animal info (male, C57BL/6, 11 wks old); ischemia (renal); 7-day pump used; post op. care (buprenorphine in saline).

Q2125 Ozumi,K., Sudhahar,V., Kim,H.W., Chen,G.F., Kohno,T., Finney,L., Vogt,S., McKinney,R.D., Ushio-Fukai,M., Fukai,T. Role of Copper Transport Protein Antioxidant 1 in Angiotensin II-Induced Hypertension A Key Regulator of Extracellular Superoxide Dismutase. Hypertension 2012; 60(-2-):476-U487. >>> Angiotensin II; Tempol; Saline; SC; Mice; 2002; 7 days; Controls received mp w/ vehicle; animal info (Atox1 -/-, 3 mo old); blood pressure measured via tail cuff.

Q1904 Fujita,M., Ando,K., Kawarazaki,H., Kawarasaki,C., Muraoka,K., Ohtsu,H., Shimizu,H., Fujita,T. Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced Chronic Kidney Disease. Hypertension 2012; 59(-1-):105-U259. >>> Tempol; CSF, artificial; CSF/CNS; IP; Rat; 2002; 4 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 3 wks old); pumps replaced after 2 week; cannula placement verified by ICV injection of Evans Blue dye after euthanization.

Q1866 Loinard,C., Zouggari,Y., Rueda,P., Ramkhelawon,B., Cochain,C., Vilar,J., Recalde,A., Richart,A., Charue,D., Duriez,M., Mori,M., renzana-Seisdedos,F., Levy,B.I., Heymes,C., Silvestre,J.S. C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression. Circulation 2012; 125(-8-):1014-U126. >>> Tempol; Mice; 2002; ; Controls received mp w/ saline; animal info (CHOP-10 deficient, wt, 28 g, 8 wks old); ischemia.

Q1702 Willett,N.J., Kundu,K., Knight,S.F., Dikalov,S., Murthy,N., Taylor,W.R. Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress. ANTIOXIDANTS&REDOX SIGNALING 2011; 15(-5-):1369-1378. >>> Tempol; ebselen; DMSO; saline; SC; IV (jugular); Mice; 2ML1; 1007D; 4 days; Animal info (male, 11-13 wks old, C57BL/6, P47 phox -/-); 50% DMSO used.

Q1156 Kappers,M.H.W., Smedts,F.M.M., Horn,T., van Esch,J.H.M., Sleijfer,S., Leijten,F., Wesseling,S., Strevens,H., Danser,A.H.J., van den Meiracker,A.H. The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System. Hypertension 2011; 58(-2-):295-U351. >>> Tempol; SC; Rat; 2ML2; 8 days; Animal info (male, Wistar, Kyoto, 280-300 g).

P9880 Wu,K.L.H., Hsu,C., Chan,J.Y.H. Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):965-977. >>> Methylisothiourea, S-; PTIO, carboxy-; Coenzyme Q10; tempol; FeTMPyP; furosemide; PJ-34; CSF, artificial; sesame oil; CSF/CNS (spinal cord); Rat; 1003D; 3 days; Controls received mp w/ vehicle; multiple pumps per animal (2); post op. care (procraine penicillin); adult, male, specific pathogen free, 200-250 g.); spinal cord injury; PE-10 catheter used; PTIO is a NO trapping agent; enzyme inhibitor PJ-34 is poly(ADP-ribose) polymerase PARP inhibitor.

P9759 Ge,N.N., Brodie,H.A., Tinling,S.P. Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase. OTOLOGY&NEUROTOLOGY 2008; 29(-8-):1061-1067. >>> Superoxide dismutase; CSF, artificial; CSF/CNS (intrathecal); Gerbil; 1002; 14 days; Controls received IM injections of SOD; half-life (p.1065) 40 hours; animal info (8 wks old, male, Mongolian); dental cement used to hold tubing in place; silastic tubing used; image of surgical placement of pumps fig.2., fig. 4.

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions; bilateral infusion;.

P9252 Qin,Z.Y., Gongora,M.C., Ozumi,K., Itoh,S., Akram,K., Ushio-Fukai,M., Harrison,D.G., Fukai,T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; 14 days; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

P9217 Silva,G.B., Garvin,J.L. Angiotensin II-Dependent Hypertension Increases Na Transport-Related Oxygen Consumption by the Thick Ascending Limb. Hypertension 2008; 52(-6-):1091-1098. >>> Angiotensin II; dye, coomassie blue R250; G86976; tempol; SC; kidney (outer medulla); Rat; 1007D; 4, 7 days; Controls received mp w/ vehicle; tissue perfusion (kidney); functionality of mp verified by residual volume and dye infusion; enzyme inhibitor (PKC a/b); cardiovascular; antihypertensive; peptide; cyanoacrylate adhesive; animal info (Sprague Dawley, 7 wks old, 200-250 g.); catheter fenestrated in one side 10 mm from the tip.

P9146 Zhang,Z.H., Yu,Y., Kang,Y.M., Wei,S.G., Felder,R.B. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1067-H1074. >>> Aldosterone; RU-28318; Tempol; losartan; CSF, artificial; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague Dawley, 250-300 g.); silastic tubing used; dental cement used.

P9076 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons. Circulation Research 2008; 103(-2-):186-193. >>> Tempol; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; animal info (New Zealand, White, 3.5-4.3 kg.); 19 gauge cannula used.

P9074 Xue,B.J., Zhao,Y.Z., Johnson,A.K., Hay,M. Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1025-H1032. >>> Tempol; estradiol, 17B-; ICI-182780; SC; CSF/CNS; Mice; 1002; 7, 14 days; ALZET brain infusion kit used; peptides; animal info (male, C57BL/6, 12-16 wks old); location of cannula was verified histologically post mortem.

P9053 Kang,Y.M., Ma,Y., Elks,C., Zheng,J.P., Yang,Z.M., Francis,J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappa B. Cardiovascular Research 2008; 79(-4-):671-678. >>> Losartan; SN50; tempol; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-275 g.); pumps were primed in 0.9% saline for 24 hours; SN50 is a synthetic protein.

P7696 Wu,D.C., Teismann,P., Tieu,K., Vila,M., Jackson-Lewis,V., Ischiropoulos,H., Przedborski,S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc.Natl.Acad.Sci.U.S.A 2003/5/13; 100(-10-):6145-6150. >>> Tempol; CSF/CNS (striatum); Mice; 7 days; Neurodegenerative (Parkinson's disease).

P7413 Welch,W.J., Mendonca,M., Blau,J., Karber,A., Dennehy,K., Patel,K., Lao,Y.S., Jose,P.A., Wilcox,C.S. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney International 2005; 68(-1-):179-187. >>> Tempol; NaCl; SC; Rat; 2002; ; Controls received mp w/ vehicle; cardiovascular; animal info (male, wistar-kyoto, 210-300 g).

P7123 Kimura,Y., Hirooka,Y., Sagara,Y., Ito,K., Kishi,T., Shimokawa,H., Takeshita,A., Sunagawa,K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circulation Research 2005; 96(-2-):252-260. >>> Tempol; CSF, artificial; CSF/CNS (cisterna); Rat; 1002; 1 week; Controls received mp w/ vehicle; comparison of CSF/CNS microinjections vs. mp; cardiovascular.

P7099 Benn,S.C., Ay,I., Bastia,E., Chian,R.J., Celia,S.A., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of Neurochemistry 2005; 95(-4-):1118-1131. >>> Toxin, tetanus fragment C; tempol, toxin tetanus fragment C; CSF/CNS; Mice; 2001; 7 days; Stability verified by incubation at 37C for 7 days; brain tissue distribution; post op. care (bupivicaine and betadine in wound); animal info (C57BL/6, male, 25-30 g); dental cement used for cannula adhesion, agent also know as TTC; compounds were also distributed to further brain sites such as the hypothalamus and the thalamus.

P7013 Welch,W.J., Blau,J., Xie,H., Chabrashvili,T., Wilcox,C.S. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H22-H28. >>> Angiotensin II; tempol; Sodium chloride; SC; Rat; 2002; 12-13 days; Controls received mp w/ vehicle; no stress (pg. H23); cardiovascular; antihypertensive; peptides; multiple pumps per animal (2).

P6143 Kawada,N., Imai,E., Karber,A., Welch,W.J., Wilcox,C.S. A mouse model of angiotensin II slow pressor response: Role of oxidati ve stress. Journal of the American Society of Nephrology 2002; 13(-12-):2860-2868. >>> Angiotensin II; tempol; Saline; SC; Mice; 1002; 14 days; Blood pressure taken; dose-response (p. 2862); cardiovascular; peptides.

P6059 Sedeek,M.H., Llinas,M.T., Drummond,H., Fortepiani,L., Abram,S.R., Alexander,B.T., Reckelhoff,J.F., Granger,J.P. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 2003; 42(-4-):806-810. >>> Endothelin-1; tempol; IV (jugular); Rat; 2002; 9 days; Peptides.

P5848 Gariboldi,M.B., Ravizza,R., Petterino,C., Castagnaro,M., Finocchiaro,G., Monti,E. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol - a potential new therapeutic agent for gliomas. European Journal of Cancer 2003; 39(-6-):829-837. >>> Tempol; Saline, sterile; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; comparison of IP injections vs. mp; adverse reaction: (see pg. 835) precipitation in pump; cancer (glioma); antioxidant; tempol (TPL) or (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxy) or superoxide dismutase, mimetic is a stable nitroxide free radical; "375 mg/ml concentration was highest achievable TPL concentration, when this limit was exceeded, TPL precipitation occurred, impairing drug flow from the pump...".

P5654 Welch,W.J., Mendonca,M., Aslam,S., Wilcox,C.S. Roles of oxidative stress and AT(1) receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Hypertension 2003; 41(-3-):692-696. >>> Tempol; Rat; 2 weeks; Antihypertensive; also refered as superoxide dismutase, mimetic.

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3115 Truelove,D., Shuaib,A., Ijaz,S., Richardson,S., Kalra,J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem.Res. 1994; 19(-6-):665-671. >>> Tempol; catalase; CSF/CNS; Gerbil; 1007D; 7 days; Controls received mp with saline; agents given separately and together; ischemia (cerebral).

P3114 Truelove,D., Shuaib,A., Ijaz,S., Ishaqzay,R., Kalra,J. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils. Free Rad.Biol.Med. 1994; 17(-5-):445-450. >>> Superoxide dismutase-PEG; Saline; CSF/CNS; gerbil; 1007D; 6 days; controls received mp with vehicle; ischemia (cerebral).

P2520 Macdonald,R.L., Weir,B.K.A., Runzer,T.D., Grace,M.G.A., Poznansky,M.J. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30(-4-):529-539. >>> Catalase; tempol; CSF/CNS (spinal cord, intrathecal); monkey; 2ML1; 7 days; controls received inactivated SOD and BSA; functionality of mp verified by measuring enzyme levels in CSF during infusion and testing agent released from pump in vitro for 7 days; stability verified by measuring activity of enzymes released from pumps in vitro over 7 days; daily CSF sampling performed using a subcutaneous Ommaya reservoir; authors report no cases of catheter blockage or dislodgement.

P2438 Suzuki,S., Kanashiro,M., Hayashi,R., Amemiya,H. Rescue therapy for acute rejection using 15-deoxyspergualin (DSG) in combination with superoxide dismutase (SOD) on cardiac allografts in rats. Transplant.Int. 1992; 5(-Sup.1-):S547-S551. >>> Sodium oxide dismutase, recomb. human (tempol); Saline; IV (vena cava); rat; 2001; 8 days; dose-response (graph p. S550).

P1931 Hattori,T., Ito,M., Suzuki,Y. Changes in intra-renal scavenging enzymes activities of the reactive oxygen species in experimental glomerulo-nephritis and nephrosis in rats. Nippon Jinzo Gakkai Shi 1991; 33(-2-):191-199. >>> Glutathione peroxidase; Catalase; tempol; rat; no duration posted; Japanese with English abstract.

P1741 Mossman,B.T., Marsh,J.P., Sesko,A., Hill,S., Shatos,M.A., Doherty,J., Petruska,J., Adler,K.B., Hemenway,D., Mickey,R., Vacek,P., Kagan,E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am.Rev.Respir.Dis. 1990; 141(--):1266-1271. >>> Catalase; tempol; PBS; SC; rat; 2ML4; 10, 20 days; functionality of mp verified by serum catalase; PEG-conjugated enzymes; antioxidants; stability of enzymes questioned beyond 20 days.

P1476 Teixeira,A.A., Azevedo,I., Branco,D., Rodrigues-Pereira,E., Osswald,W. Sympathetic denervation caused by long-term noradrenaline infusions; prevention by desipramine and superoxide dismutase. Br.J.Pharmacol. 1989; 97(--):95-102. >>> Desipramine HCl; Norepinephrine; tempol; EDTA; Heparin; Saline; IV (saphenous); dog; 2ML1; 5 days; dose-response; implanted sc above the knee; functionality of mp verified by visual inspection of sectioned pump and by serum levels; tissue perfusion; animal info (m, 9-15 kg); 5000 Units of heparin.

P0153 Gold,G., Manning,M., Heldt,A., Nowlain,R., Pettit,J.R., Grodsky,G.M. Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase. Diabetes 1981; 30(--):634-638. >>> Tempol; Saline; SC; mice; 7 days; comparison of iv injection vs. infusion.

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13. Tolmetin

P2007 Rodgers,K.E., Girgis,W., diZerega,G.S. Effect of tolmetin sodium dihydrate on adhesion formation by intraperitoneal administration of antineoplastic agents. Cancer Chemother.Pharmacol. 1992; 29(--):248-251. >>> Doxorubicin HCl; Mitoxantrone; Tolmetin sodium; Bleomycin; Cisplatin; Methotrexate; PBS; IP; rat; 2ML1; 7 days; Antibiotic; cancer; no stress (see p249).

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14. Zomepirac

S0199 Cowan,A., Tortella,F.C., Gmerek,D.E. EEG and behavioral studies with zomepirac sodium in rats. Pain 1981; 11(-1-):194-. >>> Zomepirac, sodium; Water; CSF/CNS; SC; rat; 2001; no duration posted; 7 days icv, 3 days sc.

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What researchers are saying ...

“The implanted pumps offered an advantageous alternative to repeated injections. During drug delivery, no external connection was required, and rats were untethered and unrestrained, thereby minimizing animal handling stress” Zhang et al., Journal of Neurophysiology 2000;84:798-805.