References on Pain Research Using ALZET® Osmotic Pumps

16305 Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R., Kessler, J. A. Role of adult hippocampal neurogenesis in persistent pain. Pain 2016; 157(-2-):418-28. >>> AraC; Saline; CSF/CNS (lateral ventricle); mice; 1002; Controls received mp w/ vehicle; animal info (C57Bl/6 male mice, 8-9 wks old); dose-response (pg 421); behavioral testing (touch and cold sensitivity of injured paw, Von Frey, Tail suspension test, Open field, Black-box emergence test);“Mice show fullbehavioral and functional recovery soon after surgery” pg 419; Brain coordinates; 0.4mmposterior to the bregma, 1mmlateral to the midline, and 2 mm ventral to the skull.

16297 Bravo, L., Mico, J. A., Rey-Brea, R., Camarena-Delgado, C., Berrocoso, E. Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats. Prog Neuropsychopharmacol Biol Psychiatry 2016; 70(--):57-67. >>> Desipramine; Saline; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (Adult male Harlan Sprague-Dawley rats, 200-250 g); functionality of mp verified by pain level measurements; functionality of mp verified by pain level measurements; Noradrenaline reuptake inhibitor; Chronic Constriction Injury (CCI); Therapeutic indication (Pain); Dose (10 mg/kg/d);.

16282 Zhang, K., Ramamurthy, S., Prihoda, T. J., Eckmann, M. S. Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. J Pain Res 2014; 7(--):547-54. >>> Capsaicin; Saline, Tween 80, Ethanol; CSF/CNS (intrathecal); Rat; 2001D, 2001; Controls received mp w/ vehicle; animal info ( Male adult Sprague Dawley rats, 250-300 g); 1.5% Ethanol, 1.5% Tween 80 used; good methods (pg 548, 549); ischemia (sciatic nerve); behavioral testing (Plantar Test, Von Frey Test); Ligature of the sciatic nerve (Chronic constriction injusry of sciatic nerve); Therapeutic indication (Neuropathic Pain); Dose (1.5 ug/ul);.

16321 Maral Tajerian, M.Sc., Ph.D.,, David Leu, M.Sc.,, Phillip Yang, B.Sc.,, Ting Ting Huang, Ph.D.,, Wade S. Kingery, M.D., J., David Clark, M.D., Ph.D. Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice. Anesthesiology 2015; 123(-6-):1435-1447. >>> Ketamine; Saline, sterile; SC; mice; 1007D; Controls received mp w/ vehicle; animal info (Male C57/B6J mice aged 12 to 14 weeks); good methods (pg 1436); behavioral testing (pg 1437); Limb fracture; pumps removed 8 days after implantation; Dose (2 mg/kg/day);.

16188 Tamagawa, T., Shinoda, M., Honda, K., Furukawa, A., Kaji, K., Nagashima, H., Akasaka, R., Chen, J., Sessle, B. J., Yonehara, Y., Iwata, K. Involvement of Microglial P2Y12 Signaling in Tongue Cancer Pain. J Dent Res 2016; 95(-10-):1176-82. >>> MRS2395; DMSO; PBS; CSF/CNS (cisterna magna); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Fischer, 100-200g); 25% DMSO used; cancer (tongue squamous cell carcinoma SCC-158, JCRB0231; JCRB); behavioral testing (head-withdrawal); tissue perfusion (cisterna magna); used PE tubing 0.8mm diameter; MRS2395 is an P2Y12R antagonist;.

16089 Zhuang, X., Chen, Y., Zhuang, X., Chen, T., Xing, T., Wang, W., Yang, X. Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway. Front Neurol 2016; 7(--):104. >>> Interleukin-1, receptor antagonist; SC144; etanercept; muscimol; CSF, artificial; CSF/CNS (midbrain periaqueductal gray); Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 150-200g); ALZET brain infusion kit used; neurodegenerative (Parkinson’s disease); behavioral testing (paw withdrawal latency; von Frey filaments); SC144 is an gp130 antagonist; etanercept is a TNF-a receptor antagonist; muscimol is a GABAa receptor agonist; Brain coordinates (7.6 mm posterior to the bregma 0.65 mm lateral to the midline, and 4.2 mm ventral to thebrain surface.);.

16033 Rakesh Kumar,, K. H. Reeta,, Subrata Basu Ray  Indian Journal of Experimental Biology 2014; 52(--):317-322. >>> loperamide; morphine; PEG, saline, ethanol; CSF/CNS (intrathecal); rat; 2ML2; Controls received mp w/ vehicle; animal info (adult male Sprague-dawley rats, 275-350 g); dose-response (pg 319, 320); good methods (pg. 317-318); post op. care (neomycin ointment and perioperative ketoprofen [3 mg/kg, im] given); behavioral testing (stepping placing, righting reflex, and Hargreaves paw withdrawal test); delayed delivery (lynch coil filled with saline used to delay administration of drug by 3 days; ); Dose: Morphine and Loperamide ( 0.5,1, and 2 uL/hr).

15993 Kiyomoto, M., Shinoda, M., Honda, K., Nakaya, Y., Dezawa, K., Katagiri, A., Kamakura, S., Inoue, T., Iwata, K. p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats. Mol Pain 2015; 11(--):48. >>> SB203580; DMSO; saline; CSF/CNS (cisterna magna); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 210-260g); 10% DMSO used; used PE tubing; Dose (8 umol/day);.

15968 Lefevre, Y., Amadio, A., Vincent, P., Descheemaeker, A., Oliet, S. H., Dallel, R., Voisin, D. L. Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats. Neurosci Lett 2015; 603(--):42-7. >>> Fluoroacetate; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (male, adult, Wistar, 150-175g); Dose (5 nmoles/hr);.

15934 Mundt, Sarah, Marcus Groettrup, and Michael Basler  Altex 2015; 32(-3-):183-189. >>> Buprenorphine; SC; Mice; 1007D; Controls received mp w/ PBS; animal info (female, C57BL6, 8 weeks old); behavioral testing (pain score);“we used subcutaneously implanted ALZET®osmotic pumps to apply the analgesic buprenorphine. We ob¬served strongly reduced pain scores in diseased mice receiving analgesics, whereas the immune response was not altered in these mice. Hence, our study offers a new treatment option to improve wellbeing of mice used to study LCMV-induced meningitis without grossly altering immune parameters” pg 184;"In this study, we subcutane¬ously implanted ALZET®osmotic pumps releasing the anal¬gesic agent buprenorphine. Continuous delivery with osmotic pumps ensures constant compound levels for maximized thera-peutic efficacy and reduced adverse effects. Additionally, un¬necessary stressful animal handling due to repeated injection is not required."pg 188; Dose (0.15 mg/kg/day);.

15853 Yamanaka, H., Kobayashi, K., Okubo, M., Noguchi, K. Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator. Neuroscience 2016; 314(--):189-99. >>> Homocysteine; tPA; PBS; CSF/CNS (intrathecal); Rat; 2001; 2001D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); dose-response (pg195); behavioral testing (mechanical withdrawal threshold); Dose (homocysteine 1.2 umol/day or 120 nmol/day; tPA 2 ug/day);.

15777 Zongming Jiang, Shaoyong Wu, Xiujuan Wu, Junfeng Zhong, Anqing Lv, Jing Jiao, Zhonghua Chen  International Journal of Cancer 2016; 138(--):2013-2020. >>> Rapamycin; CTOP; LY297002; DMSO; saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (Wistar, 200-250g); 50% DMSO used; cancer (breast; bone); dose-response (pg 2015); behavioral testing (hindpaw withdrawal latency); Rapamycin is an mTOR antagonist; CTOP is an MOR antagonist; LY297002 an a PI3K inhibitor;.

15197 Buys, M.J., Alphonso, C., Buys, M.J. Novel Use of Perineural Pregabalin Infusion for Analgesia in a Rat Neuropathic Pain Model1809. ANESTHESIA AND ANALGESIA 2014; 119(--):481-488. >>> Pregabalin; Saline; CSF/CNS (sciatic nerve); Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8-9 weeks old); behavioral testing (Hargreaves'radient heat testing, guarding behavior, incapacitance testing); pump and catheter secured using 4-0 silk suture; sciatic nerve injury;.

15182 Okada-Ogawa, A., Nakaya, Y., Imamura, Y., Kobayashi, M., Shinoda, M., Kita, K., Sessle, B.J., Iwata, K., Okada-Ogawa, A. Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection. EXPERIMENTAL NEUROLOGY 2015; 267(--):42-52. >>> R-DIOA; DMSO; saline; CSF/CNS (intrathecal); Rat (transgenic); 2001; Controls received mp w/ vehicle; animal info (male, VGAT-Venus Tg); 10% DMSO used; behavioral testing (von Frey filaments); used microsilicon tubing (0.8 mm in diameter) see pg. 44; R-DIOA is a KCC2 (potassium-chloride co-transporter 2) blocker; neuropathic pain;.

15053 Nieto, F.R., Clark, A.K., Grist, J., Chapman, V., Malcangio, M., Malcangio, M. Calcitonin Gene-Related Peptide-Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen-Induced Arthritis. ARTHRITIS&RHEUMATOLOGY 2015; 67(--):1668-1677. >>> Calcitonin gene-related peptide (8-37); CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (female, Lewis, 180-200g); behavioral testing (Von Frey filaments; Plantar test); immunology; peptides;.

15022 Fukuoka, T., Noguchi, K., Fukuoka, T. A POTENTIAL ANTI-ALLODYNIC MECHANISM OF GDNF FOLLOWING L5 SPINAL NERVE LIGATION; MITIGATION OF NPY UP-REGULATION IN THE TOUCH SENSE PATHWAY. NEUROSCIENCE 2015; 304(--):240-249. >>> Glial cell line-derived neurotrophic factor; Saline; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, young adult, 220-230g); behavioral testing (paw withdrawal);.

14996 Kline, R.H., Exposto, F.G., O'Buckley, S.C., Westlund, K.N., Nackley, A.G., Nackley, A.G. CATECHOL-O-METHYLTRANSFERASE INHIBITION ALTERS PAIN AND ANXIETY-RELATED VOLITIONAL BEHAVIORS THROUGH ACTIVATION OF beta-ADRENERGIC RECEPTORS IN THE RAT. NEUROSCIENCE 2015; 290(--):561-569. >>> Propranolol; OR486; DMSO; ethanol; saline; SC; Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 325-425g); behavioral testing (thermal place preference; light/dark preference; tactile allodynia); cardiovascular;"We attribute the overall differences in exploratory activity between the acute and chronic cohorts possibly due to the anxiety-provoking effects of repetitive i.p. injections in the acute but not the chronic cohort"pg 565;.

14908 Chen, Y.L., Tsaur, M.L., Wang, S.W., Wang, T.Y., Hung, Y.C., Lin, C.S., Chang, Y.F., Wang, Y.C., Shiue, S.J., Cheng, J.K., Cheng, J.K. Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats. BRITISH JOURNAL OF ANAESTHESIA 2015; 115(--):105-111. >>> Mibefradil; ethosuximide; nickel chloride; Saline; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g, spinal ligation); behavioral testing (von frey filament, hindpaw withdrawal latency);.

14837 Bao, Y.J., Gao, Y.B., Hou, W., Yang, L.P., Kong, X.Y., Zheng, H.G., Li, C.H., Hua, B.J., Hua, B.J. Engagement of signaling pathways of protease-activated receptor 2 and -opioid receptor in bone cancer pain and morphine tolerance. INTERNATIONAL JOURNAL OF CANCER 2015; 137(--):1475-1483. >>> FSLLRY-NH2; Saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (Wistar 200-250g); cancer (bone); no stress (see pg. 1476); behavioral testing (mechanical paw withdrawal, thermal hyperalgesia); peptides;.

14768 Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y.S., Klip, A., Ji, R.R., Zhang, J., Salter, M.W., Mogil, J.S., Mogil, J.S. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. NATURE NEUROSCIENCE 2015; 18(--):1081-+. >>> Testosterone; Polyethylene glycol; SC; Mice (nude); 2002; animal info (naive, adult, young, 7-12 wks old, male, female, CD-1, nude CD-1).

14435 Tatsumi, E., Yamanaka, H., Kobayashi, K., Yagi, H., Sakagami, M., Noguchi, K., Noguchi, K. RhoA/ROCK Pathway Mediates p38 MAPK Activation and Morphological Changes Downstream of P2Y12/13 Receptors in Spinal Microglia in Neuropathic Pain. Glia 2015; 63(--):216-228. >>> H1152; MRS2395; MRS2211; 2Me-SADP; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); 5% DMSO used; behavioral testing (hindpaw withdrawal test); H1152 is a ROCK inhibitor; sciatic nerve injury;.

14366 Riera, C.E., Huising, M.O., Follett, P., Leblanc, M., Halloran, J., Van Andel, R., de Magalhaes, C.D., Merkwirth, C., Dillin, A., Dillin, A. TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling. Cell 2014; 157(--):1023-1036. >>> Calcitonin gene related peptide (8-37); Mice; Animal info (male, C57BL6J, 22 months old); functionality of mp verified by serum levels; peptides; diabetes; long-term study;.

14289 Mannelli, L.D., Pacini, A., Micheli, L., Tani, A., Zanardelli, M., Ghelardini, C., Mannelli, L.D. Glial role in oxaliplatin-induced neuropathic pain. Experimental Neurology 2014; 261(--):22-33. >>> Minocycline HCl; Sodium fluorocitrate; PBS; CSF/CNS (intrathecal); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); behavioral testing (paw pressure test; von frey test; rota-rod test ); pumps primed overnight in 37C PBS;.

14700 Cobacho, N., de la Calle, J.L., Paino, C.L., Paino, C.L. Dopaminergic modulation of neuropathic pain: Analgesia in rats by a D2-type receptor agonist. Brain Research Bulletin 2014; 106(--):62-71. >>> Quinpirole hydrochloride; Water, sterile; SC; Rat; 2ML1; Controls received sham mp; animal info (male, Sprague Dawley, adult, 250-300g); functionality of mp verified by incubating pumps after explantation in 37C saline and noted collected amount of fluid - post explantation in vitro testing; behavioral testing (tactile and cold allodynia); neuropathic pain; pumps primed in 37C saline for 2 hours;.

14610 Lu, Y., Jiang, B.C., Cao, D.L., Zhang, Z.J., Zhang, X., Ji, R.R., Gao, Y.J., Gao, Y.J. TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-alpha and IL-1beta signaling. Pain 2014; 155(--):2618-2629. >>> Oligonucleotide, antisense; oligonucleotide, mismatch; CSF/CNS (intrathecal); Mice; 1007D; Animal info (ICR, adult, male, 8 wks old); PE8 catheter used; antisense (TRAF6); neuropathic pain.

14598 Shaqura, M., Khalefa, B.I., Shakibaei, M., Zoellner, C., Al-Khrasani, M., Fuerst, S., Schaefer, M., Mousa, S.A., Mousa, S.A. New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy. Neuropharmacology 2014; 85(--):142-150. >>> Nerve growth factor, beta; albumin, rat serum; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Control animals received mp w/ animal info (male, Wistar, STZ induced diabetes).

13993 Won, K.A., Kim, M.J., Yang, K.Y., Park, J.S., Lee, M.K., Park, M.K., Bae, Y.C., Ahn, D.K. The Glial-Neuronal GRK2 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats. JOURNAL OF PAIN 2014; 15(-3-):250-261. >>> Minocycline; aminoadipic acid, L-a-; interleukin-1, receptor antagonist;; DMSO; saline; CSF/CNS (occipital membrane, cistern); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 220-240g); 20% DMSO used; behavioral testing (air-puff pressure/behavioral response withdrawal, mechanical allodynia); L-a-aminoadipic acid aka LAA; LAA is an astrocytic specific inhibitor;.

13976 Ungard, R.G., Seidlitz, E.P., Singh, G. Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain 2014; 155(-1-):28-36. >>> Sulfasalazine; carboxyphenylglycine, (S)-4-; IP; Mice (nude); 1004; Controls received mp w/ vehicle; animal info (female, nu/nu, balb/c, 4-6 weeks old, athymic, 20g); cancer (breast); behavioral testing (Dynamic weight bearing system; dynamic plantar aesthesiometer); sulfasalazine aka SSZ; notes max soluble dose of SSZ is 6.6 mg/kg/day.

13952 Yang, F., Whang, J., Derry, W.T., Vardeh, D., Scholz, J. Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat. Pain 2014; 155(-2-):356-366. >>> Pregabalin; PBS; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 2-3 months old); dose-response (p.359, fig. 1); behavioral testing (open field behavior; paw withdrawal; righting reflex); used IT catheter; cather placement verified; pregabalin is an analgesic; spared nerve injury;.

13928 Shen, X.F., Liu, Y.S., Xu, S.Q., Zhao, Q.S., Wu, H.B., Guo, X.R., Shen, R., Wang, F.Z., Wang, F.Z. Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain. Pharmacological Reports 2014; 66(--):49-55. >>> ; Mice; Animal info (male, C57BL6); ALZET intrathecal catheter only; pumps not used; fixed catheter with Histoacryl tissue glue;.

13925 Schuh, C.D., Pierre, S., Weigert, A., Weichand, B., Altenrath, K., Schreiber, Y., Ferreiros, N., Zhang, D.D., Suo, J., Treutlein, E.M., Henke, M., Kunkel, H., Grez, M., Nuesing, R., Bruene, B., Geisslinger, G., Scholich, K. Prostacyclin mediates neuropathic pain through interleukin 1beta-expressing resident macrophages. Pain 2014; 155(-3-):545-555. >>> CAY10441; PBS; DMSO; CSF/CNS (sciatic nerve); Mice; 1007D; Controls received mp w/ vehicle; animal info (C57BL6N or IP receptor KO mice); 1% DMSO used; behavioral testing (paw withdrawal latency); immunology; sciatic nerve injury; used RenaSil tube attached to PE-60, and fixed by Stabiloblast 2-component glue; pumps primed in 37C saline; pumps implanted subcutaneously and fixed with 6-0 Prolene suture to muscle; CAY10441 is an IP receptor antagonist;.

13914 Rodgers, H.M., Liban, S., Wilson, L.M. Attenuated pain response of obese mice (B6.Cg-lep(ob)) is affected by aging and leptin but not sex. PHYSIOLOGY&BEHAVIOR 2014; 123(-;-):80-85. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (ob/ob, B6.Cg-lepob, 41-42 weeks old]); behavioral testing (tail-flick, water intake); diabetes; used wound clips;.

13843 Lantero, A., Tramullas, M., Pilar-Cuellar, F., Valdizan, E., Santillan, R., Roques, B.P., Hurle, M.A., Hurle, M.A. TGF-beta and Opioid Receptor Signaling Crosstalk Results in Improvement of Endogenous and Exogenous Opioid Analgesia under Pathological Pain Conditions. Journal of Neuroscience 2014; 34(--):5385-5395. >>> Transforming growth factor-B1; HCl; albumin; SC; Mice (transgenic); 1002; Controls received mp w/ vehicle; animal info (male, BAMBI-KO or WT, 14-18 weeks old); behavioral testing (von Frey monofiliments; formalin test); Transforming growth factor-B1 aka TGF-B1; sciatic nerve crush injury;.

13817 Jarvis, M.F., Scott, V.E., McGaraughty, S., Chu, K.L., Xu, J., Niforatos, W., Milicic, I., Joshi, S., Zhang, Q.W., Xia, Z.R., Jarvis, M.F. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochemical Pharmacology 2014; 89(--):536-544. >>> Vincristine sulfate; IV (jugular); Rat; 2002; Animal info (male, Sprague Dawley, 200-420g); behavioral testing (paw withdrawal); pumps primes overnight; used PE-60 catheter tubing; chemotherapy-induced neuropathic pain model;.

13816 Janes, K., Little, J.W., Li, C., Bryant, L., Chen, C., Chen, Z.M., Kamocki, K., Doyle, T., Snider, A., Esposito, E., Cuzzocrea, S., Bieberich, E., Obeid, L., Petrache, I., Nicol, G., Neumann, W.L., Salvemini, D., Salvemini, D. The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1. Journal of Biological Chemistry 2014; 289(--):21082-21097. >>> FTY720; NIBR-14; CYM5442; DMSO; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, adult, 200-220g); 100% DMSO used; dose-response (pg 21089); behavioral testing (mechanical paw withdrawal threshold, tail flick test); immunology;.

13813 Itokazu, T., Hayano, Y., Takahashi, R., Yamashita, T., Yamashita, T. Involvement of Wnt/beta-catenin signaling in the development of neuropathic pain. NEUROSCIENCE RESEARCH 2014; 79(--):34-40. >>> XAV939; wnt3a, recombinant; DMSO; PBS; BSA; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 8-10 weeks old, 200-250g); 10% DMSO used; behavioral testing (von Frey filaments; withdrawal threshold); Catheter placement verified via 25ul of 2% lidocane followed by 10ul saline flush - hind paw paralysis indicated success; sciatic nerve ligation;.

13802 He, L., Ueceyler, N., Kraemer, H.H., Colaco, M.N., Lu, B., Birklein, F., Sommer, C. Methylprednisolone prevents nerve injury-induced hyperalgesia in neprilysin knockout mice. Pain 2014; 155(-3-):574-580. >>> Methylprednisolone sodium succinate; Saline; Mice; 1007D; Controls received mp w/ vehicle; animal info (NEP ko or WT, 12-13 weeks old); behavioral testing (paw withdrawal latency; von Frey hairs);.

13733 Chang, P.C., Pollema-Mays, S.L., Centeno, M.V., Procissi, D., Contini, M., Baria, A.T., Martina, M., Apkarian, A.V., Apkarian, A.V. Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain. Pain 2014; 155(--):1128-1139. >>> Lidocaine; Saline; CNS/CSF (nucleus accumbins); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 200-250g); behavioral testing (von Frey filaments; cold sensitivity); Cannula placement verified via histologic analysis; spared nerve injury; 2% lidocane infused; used Plastics One injector attached to pump with vinyl tubing;.

 

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“Unlike injected nicotine, the infusion of nicotine via osmotic minipumps does not cause any overt signs of hypoxia/ischemia, such as blanching of the skin or cyanosis.” Xu et al., Brain Research 2002; 951:280-292.