References on the Administration of Agents to Primates Using ALZET^® Osmotic Pumps

1. Baboons

P9110 Banaszak,S., Brudney,A., Donnelly,K., Chai,D., Chwalisz,K., Fazleabas,A.T. Modulation of the action of chorionic gonadotropin in the baboon (Papio anubis) uterus by a progesterone receptor antagonist (ZK 137. 316). Biol.Reprod. 2000/9; 63(-3-):820-825. >>> Gonadotrophin, human chorionic; Intraovarian; Monkey (baboon); 4 days; Animal info (ovariectomized).

P8047 Sherwin,J.R.A., Sharkey,A.M., Cameo,P., Mavrogianis,P.M., Catalano,R.D., Edassery,S., Fazleabas,A.T. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148(-2-):618-626. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); 5 days; Animal info (female, adult).

P7516 Strakova,Z., Mavrogianis,P., Meng,X.M., Hastings,J.M., Jackson,K.S., Cameo,P., Brudney,A., Knight,O., Fazleabas,A.T. In vivo infusion of interleukin-1 beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon. Endocrinology 2005; 146(-9-):4097-4104. >>> Gonadotrophin, human chorionic, recomb.; interleukin-1, beta, recomb. human; interleukin-1 receptor antagonist, recomb. human; Oviductal; Monkey (baboon); 10 days; Controls received no treatment; pumps replaced at day 5; animal info (female, adult).

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

P5297 Hart,C.E., Kraiss,L.W., Vergel,S., Gilbertson,D., Kenagy,R., Kirkman,T., Crandall,D.L., Tickle,S., Finney,H., Yarranton,G., Clowes,A.W. PDGFbeta receptor blockade inhibits intimal hyperplasia in the baboon. Circulation 1999/2/2; 99(-4-):564-569. >>> Heparin, porcine; Saline; IV (femoral); Monkey (baboon); 4, 28, 56 days; Controls received mp w/ vehicle; pumps replaced after 28 days; cardiovascular; multiple pumps per animal (2).

P4163 Fazleabas,A.T., Donnelly,K.M., Srinivasan,S., Fortman,J.D., Miller,J.B. Modulation of the baboon (papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity. Proc.Natl.Acad.Sci.USA 1999; 96(--):2543-2548. >>> Gonadotrophin, recomb. human chorionic; Intraovarian (corpus luteum); Monkey (baboon); 2ML1; 7 days; tissue perfusion (corpus luteum).

P4060 Blair-West,J.R., Carey,K.D., Denton,D.A., Weisinger,R.S., Shade,R.E. Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.44) 1998; 275(--):R1639-R1646. >>> Angiotensin II; Losartan potassium; ZD-7155; Ethanol; CSF, artificial;; SC; CSF/CNS;; Monkey (baboon); 2ML1; 2ML2; 2ML4; no duration posted; controls received mp w/vehicle; amoxicillin and buprenorphine given post-operatively; good methods; aCSF delivered during 1-2 week surgical recovery period; vehicle and compound-filled pumps were alternated; some pumps were filled with peptide and antagonist; ZD-7155 is an AT1 receptor antagonist; peptides; antihypertensive.

P1880 Kang,I.S., Kuehl,T.J., Siler-Khodr,T.M. Effect of treatment with gonadotropin-releasing hormone analogues on pregnancy outcome in the baboon. Fertil.Steril. 1989; 52(-5-):846-853. >>> Luteinizing HRH antagonist; Water; SC; Monkey (baboon, pregnant); 7 days; no comment posted.

P1465 Brailowsky,S., Silva-Barrat,C., Menini,C., Riche,D., Naquet,R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr.Clin.Neurophysiol. 1989; 72(--):147-156. >>> Aminobutyric acid, Y-; Saline; CSF/CNS; Monkey (baboon); 2ML1; 7 days; functionality of mp verified by removing and opening; pumps replaced once w/ saline-filled mp.

P1023 Brailowsky,S., Menini,C., Silva-Barrat,C., Naquet,R. Epileptogenic y-aminobutyric acid-withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci.Lett. 1987; 74(--):75-80. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (frontal cortex); Monkey (baboon); 2ML1; no duration posted; controls received mp w/vehicle; mp connected to intracerebral cannula; agent filled mp replaced after 7 days with saline filled mp; tissue perfusion (frontal cortex).

P0035 Hagino,N., Nakamoto,O., Kunz,Y., Arimura,A., Coy,D.H., Schally,A.V. Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon. Acta Endocrinol. 1979; 91(-2-):217-223. >>> Luteinizing HRH agonist; Saline; SC; Monkey (baboon); 7 days; peptides.

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2. Monkey (2000-2009)

P9193 Samadi,P., Morissette,M., Calon,F., Tahar,A.H., Dridi,M., Belanger,N., Meltzer,L.T., Bedard,P.J., Di Paolo,T. Normalization of GABAA receptor specific binding in the substantia nigra reticulata and the prevention of L-dopa-induced dyskinesias in MPTP Parkinsonian monkeys. Synapse 2008; 62(-2-):101-109. >>> MPTP; Water, sterile; SC; Monkey; 3.6 months; Animal info (female, OVX, cynomologus, 3.0-4.3 kg.); MPTP induced parkinsonian syndrome; "total dose and time to sustain parkinsonian features were on average 16.2 mg and 3.6 mo respectively"; neurodegenerative (Parkinson's Disease).

P9110 Banaszak,S., Brudney,A., Donnelly,K., Chai,D., Chwalisz,K., Fazleabas,A.T. Modulation of the action of chorionic gonadotropin in the baboon (Papio anubis) uterus by a progesterone receptor antagonist (ZK 137. 316). Biol.Reprod. 2000/9; 63(-3-):820-825. >>> Gonadotrophin, human chorionic; Intraovarian; Monkey (baboon); 4 days; Animal info (ovariectomized).

P9090 Wannier-Morino,P., Schmidlin,E., Freund,P., Belhaj-Saif,A., Bloch,J., Mir,A., Schwab,M.E., Rouiller,E.M., Wannier,T. Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A. Brain Research 2008; 1217(-;-):96-109. >>> Immunoglobulin G, monoclonal, mouse; antibody, anti-Nogo-A monoclonal, human; anitbody, anti-Nogo-A monoclonal, mouse; CSF/CNS (intrathecal); Monkey; 2ML2; ; Control animals received mp w/ control antibodies; animal info (macaque, 3-8 years old); pumps replaced every 2 weeks; polyethylene tubing used; spinal cord injury.

P8915 Lujan,M.E., Krzemien,A.A., Reid,R.L., Van Vugt,D.A. Effect of leptin administration on ovulation in food-restricted rhesus monkeys. Neuroendocrinology 2006; 84(-2-):103-114. >>> Leptin, recomb. human; Water, sterile; CSF/CNS; Monkey; 2002; 32 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 2 wks; stress/adverse reaction: (see pg. 104) 1 animal removed from study due to CNS infection at 28 weeks; peptides; animal info (female, Rhesus, 6-10 yrs. old, 5-12 kg.); endocrinology.

P8717 Brooks,D.E., Komaromy,A.M., Kallberg,M.E., Miyabashi,T., Ollivier,F.J., Lambrou,G.N. Blood flow velocity response of the ophthalmic artery and anterior optic nerve head capillaries to carbogen gas in the rhesus monkey model of optic nerve head ischemia. VETERINARY OPHTHALMOLOGY 2007; 10(-;-):20-27. >>> Endothelin-1; CSF/CNS (optic nerve); Monkey (Rhesus); 2004; 8 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks; peptides; animal info (young, male, Rhesus); glaucoma.

P8309 Siler-Khodr,T.M., Yu,F.Q., Wei,P., Tao,S.X., Coulhart,S., Mactyszczyk,S., Lui,Y.X. Dose-related of GnRH II analog in the cycling rhesus monkey. Contraception 2006; 74(-2-):157-164. >>> Gonadotropin-releasing hormone II, analog; PBS; SC; Monkey; 6 days; Controls received mp w/ vehicle; dose-response (fig. 1); stress/adverse reaction: (see pg. 160) 1 control (of 13) and 1 treated (of 19) animals died of diarrhea; half-life (pg. 160) 4 hours; peptides; animal info (Rhesus, female, 5-7 yrs. old); mp primed 16 hours in PBS; Endocrinology.

P8174 Belanger,N., Gregoire,L., Bedard,P.J., Di Paolo,T. DHEA improves symptomatic treatment of moderately and severely impaired MPTP monkeys. NEUROBIOLOGY OF AGING 2006; 27(-11-):1684-1693. >>> MPTP; Water, sterile; SC; Monkey; 1 month; Animal info (female, Macara fascicularis, 3.8 kg); neurodegenerative (Parkinson's disease).

P8047 Sherwin,J.R.A., Sharkey,A.M., Cameo,P., Mavrogianis,P.M., Catalano,R.D., Edassery,S., Fazleabas,A.T. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148(-2-):618-626. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); 5 days; Animal info (female, adult).

P7876 Julien,C., Berthiaume,L., Hadj-Tahar,A., Rajput,A.H., Bedard,P.J., Di Paolo,T., Julien,P., Calon,F. Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. NEUROCHEMISTRY INTERNATIONAL 2006; 48(-5-):404-414. >>> MPTP; Water, sterile; SC; Monkey; 4 weeks; Controls received no treatment; replacement therapy (ovariectomy); neurodegenerative (Parkinson's disease); animal info (female, cynomolgus, 3.0-4.3 kg.).

P7740 Sekhon,H.S., Song,P.F., Jia,Y.B., Lindstrom,J., Spindel,E.R. Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell and Tissue Research 2005; 320(-2-):287-297. >>> Nicotine tartrate; Water, bacteriostatic; SC; Monkey (pregnant); 2ML4; 19 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 3 weeks; post op. care (cefazolin); animal info (female, Rhesus, gestation day 26-160); amniocentesis.

P7622 Morissette,M., Dridi,M., Calon,F., Tahar,A.H., Meltzer,L.T., Bedard,P.J., Di Paolo,T.S. Prevention of levodopa-induced dyskinesias by a selective NR1A/2B N-methyl-D-aspartate receptor antagonist in parkinsonian monkeys: Implication of preproenkephalin. Movement Disorders 2006; 21(-1-):9-17. >>> MPTP; Water, sterile; SC; Monkey; 2-4 weeks; Controls received no treatment; neurodegenerative (Parkinson's disease); animal info (female, Cynomolgus, 3.0 - 4.3 kg, ovariectomized).

P7533 Hafstrom,O., Milerad,J., Sandberg,K.L., Sundell,H.W. Cardiorespiratory effects of nicotine exposure during development. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2005; 149(-1-3-):325-341. >>> Nicotine bitartrate; SC; Rat (pregnant); monkey (pregnant); mice (pregnant); sheep (pregnant); rat, mice, monkey, sheep (lamb); 28 days; Half-life (p. 327) 54 min in rats, 2-2.5 hours in humans, 5-7 min. in mice; teratology; "Most studies of prenatal nicotine exposure have been performed in rats using maternal continuous subcutaneous infusions by osmotic minipumps (ALZET) of nicotine bitartrate". (p. 326)..

P7516 Strakova,Z., Mavrogianis,P., Meng,X.M., Hastings,J.M., Jackson,K.S., Cameo,P., Brudney,A., Knight,O., Fazleabas,A.T. In vivo infusion of interleukin-1 beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon. Endocrinology 2005; 146(-9-):4097-4104. >>> Gonadotrophin, human chorionic, recomb.; interleukin-1, beta, recomb. human; interleukin-1 receptor antagonist, recomb. human; Oviductal; Monkey (baboon); 10 days; Controls received no treatment; pumps replaced at day 5; animal info (female, adult).

P7479 Czoty,P.W., Gage,H.D., Nader,M.A. PET imaging of striatal dopamine D2 receptors in nonhuman primates: Increases in availability produced by chronic raclopride treatment. Synapse 2005; 58(-4-):215-219. >>> Raclopride; SC; Monkey; 2ML4; 29, 31 days; Animal info (male, Cynomolgus); D2 receptor antagonist.

P7420 Shayu,D., Kesava,C.C.S., Soundarajan,R., Rao,A.J. Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey. Reproductive Biology and Endocrinology 2005; 3(--):U1-U15. >>> ICI 182,780; Propylene glycol; SC; Monkey (bonnet); 2ML4; 30-180 days; Controls received mp w/ vehicle; long-term study; pumps replaced every 28 days; ER antagonist; animal info (male, bonnet, 6-8 kg).

P7410 Samadi,P., Gregoire,L., Tahar,A.H., Di Paolo,T., Rouillard,C., Bedard,P.J. Naltrexone in the short-term decreases antiparkinsonian response to L-Dopa and in the long-term increases dyskinesias in drug-naive parkinsonian monkeys. Neuropharmacology 2005; 49(-2-):165-173. >>> MPTP; Water, sterile; SC; Monkey; 2-4 weeks; Neurodegenerative (Parkinson's disease); animal info (female, macaque, 3.7-5.1 kg).

P7370 Wilson,M.E., Fisher,J., Brown,J. Chronic subcutaneous leptin infusion diminishes the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in female rhesus monkeys. PHYSIOLOGY&BEHAVIOR 2005; 84(-3-):449-458. >>> Leptin; SC; Monkey (rhesus); 28 days; Peptides.

P7150 Proskocil,B.J., Sekhon,H.S., Clark,J.A., Lupo,S.L., Jia,Y.B., Hull,W.M., Whitsett,J.A., Starcher,B.C., Spindel,E.R. Vitamin c prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2005; 171(-9-):1032-1039. >>> Nicotine; Water; SC; Monkey (pregnant); 2ML4; 134 days; Controls received mp w/ vehicle; long-term study; pumps replaced every three weeks; teratology; post op. care (antiobiotic, twice a day for 3 days).

P7019 Slotkin,T.A., Seidler,F.J., Qiao,D., Aldridge,J.E., Tate,C.A., Cousins,M.M., Proskocil,B.J., Sekhon,H.S., Clark,J.A., Lupo,S.L., Spindel,E.R. Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: Neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology 2005; 30(-1-):129-144. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Monkey (pregnant); 2ML4; 130 days; Controls received mp w/ vehicle; functionality of mp verified by plasma nicotine levels; long-term study; pumps replaced every 3 weeks; teratology; "the infusion model used here is an appropriate simulation of continuous nicotine delivery as is typical of transdermal nicotine patches, ...and smokers (who) tend to maintain a steady-state nicotine plasma level" (pg. 141).

P6992 Wolfe,D., Niranjan,A., Trichel,A., Wiley,C., Ozuer,A., Kanal,E., Kondziolka,D., Krisky,D., Goss,J., DeLuca,N., Murphey-Corb,M., Glorioso,J.C. Safety and biodistribution studies of an HSV multigene vector following intracranial delivery to non-human primates. Gene Therapy 2004; 11(-23-):1675-1684. >>> Ganciclovir; SC; Monkey (Rhesus); 2ML1; 2ML2; 4,5,34,35 days; Pumps replaced after 2 weeks; no stress (see pg. 1677); cancer (glioblastoma); toxicology; MRI; multiple pumps per animal (2); gene therapy.

P6977 Hayes,E.S., Curnow,E.C., Trounson,A.O., Danielson,L.A., Unemori,E.N. Implantation and pregnancy following in vitro fertilization and the effect of recombinant human relaxin administration in Macaca fascicularis. Biology of Reproduction 2004; 71(-5-):1591-1597. >>> Relaxin, recomb. human; Acetate; SC; Monkey (cynomolgus); monkey (pregnant); 2004; 21 days; Controls received mp w/ vehicle; functionality of mp verified by serum rhRLX levels; no stress (see pg. 1593); good methods p. 1592; peptides; post op. care (ketoprofen, butorphanol).

P6755 Siler-Khodr,T.M., Yu,F.Q., Wei,P., Tao,S.X., Liu,Y.X. Contraceptive action of a gonadotropin-releasing hormone II analog in the Rhesus monkey. Journal of Clinical Endocrinology and Metabolism 2004; 89(-9-):4513-4520. >>> Gonadotrophin-releasing hormone II, analog; Saline, sterile; SC; Monkey; 2ML1; 6 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg.4514) one control animal "died of diarrhea"; peptides.

P6581 Pazol,K., Wilson,M.E., Wallen,K. Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female macaques. Journal of Clinical Endocrinology and Metabolism 2004; 89(-6-):2998-3006. >>> Progesterone acetate, medroxy-; progesterone; DMSO; SC; Monkey; 2ML1; 1 week; Controls received placebo; functionality of mp verified by serum hormone levels; replacement therapy (ovariectomy); pumps replaced animals received mp w/ agent 1 for 1 week, mp removed, 3 week washout period and then new mp w/ agent 2 for 1 week; peptides.

P6541 Brooks,D.E., Kaellberg,M.E., Cannon,R.L., Komaromy,A.M., Ollivier,F.J., Malakhova,O.E., Dawson,W.W., Sherwood,M.B., Kuekuerichkina,E.E., Lambrou,G.X. Functional and structural analysis of the visual system in the rhesus monkey model of optic nerve head ischemia. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-6-):1830-1840. >>> Endothelin; Saline; acetic acid; CSF/CNS (optic nerve); Monkey; 18 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 6 weeks; no stress (see pg. 1833); peptides; "The osmotic minipumps were well tolerated by the monkeys for the length (1.5 years) of the experiment." The long exposure time was used to "mimic more closely the prolonged human glaucomatous condition." p. 1838; pump model not listed; ischemia.

P6430 Belanger,N., Gregoire,L., Tahar,A.H., Bedard,P.J. Chronic treatment with small doses of cabergoline prevents dopa-induced dyskinesias in Parkinsonian monkeys. Movement Disorders 2003; 18(-12-):1436-1441. >>> MPTP; Saline; Monkey (cynomolgus); ; Neurodegenerative (Parkinson's disease); pump model not listed.

P6348 Marshall,J.W.B., Ridley,R.M. Assessment of cognitive and motor deficits in a marmoset model of stroke. ILAR JOURNAL 2003; 44(-2-):153-160. >>> Clomethiazole; AR-R15896AR; NXY-059; Saline; SC; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; pumps replaced every 24 hours; ischemia (cerebral); neuroprotective; post op. care (incubator); behavioral study.

P6295 Kim,C-J., Bassiouny,M., Macdonald,R.L., Weir,B., Johns,L.M. Effect of BQ-123 and Tissue Plasminogen Activator on Vasospasm After Subarachnoid Hemorrhage in Monkeys. Stroke 1996; 27(-9-):1629-1633. >>> BQ123; Saline, physiological; CSF/CNS (cisterna); Monkey; 2ML1; 7 days; Controls received mp w/ vehicle; sterility verified by microbiological culture; peptides; multiple pumps per animal (2); tissue plasminogen activator given to 1 group via intracisternal injection.

P6218 Blanchet,P.J. The fluctuating parkinsonian patient - Clinical and pathophysiological aspects. Canadian Journal of Neurological Sciences 2003; 30(--):S19-S26. >>> Dopamine, agonists; SC; Monkey; ; Pump model and duration not listed; neurodegenerative (Parkinson's disease).

P6197 Marshall,J.W.B., Green,A.R., Ridley,R.M. Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures. Brain Research 2003; 972(-1-2-):119-126. >>> Clomethiazole; AR-R15896AR; NXY-059; SC; Monkey; 2001D; 48 hours; Controls received mp w/ saline; functionality of mp verified by plasma drug concentration at 24 hours; pumps replaced after 24 hours; multiple pumps per animal (2 for NXY-059 exp); post-op care (incubator 3-5 days); AR-R15896AR is a low affinity uncompetetive NMDA antagonist; NXY-059 is a nitrone-derived free radical trapping agent; ischemia (cerebral).

P6150 Marshall,J.W.B., Cummings,R.M., Bowes,L.J., Ridley,R.M., Green,A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion. Stroke 2003; 34(-9-):2228-2233. >>> NXY-059; Saline; IV; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; NXY-059 plasma levels taken; pumps replaced every 24 hours; post op. care (flunixin meglumine); behavior study; neuroprotective; ischemia (cerebral).

P5813 Anderson,M.E., Postupna,N., Ruffo,M. Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey. Journal of Neurophysiology 2003; 89(-2-):1150-1160. >>> MPTP; CSF/CNS (putamen); Monkey; ; Briefly mentions the use of a pump for one animal (p. 1151).

P5707 Muggleton,N.G., Bowditch,A.P., Crofts,H.S., Scott,E.A.M., Pearce,P.C. Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioral effects of organophosphates in the common marmoset (Callithrix jacchus). Psychopharmacology 2003; 166(-3-):212-220. >>> Physostigmine salicylate; scopolamine hydrobromide; Saline; SC; Monkey (marmoset); 2002; 14 days; Controls received mp w/ vehicle; behavioral testing; agents infused via same pumps; toxicology.

P5528 Lallement,G., Demoncheaux,J.P., Foquin,A., Baubichon,D., Galonnier,M., Clarencon,D., Dorandeu,F. Subchronic administration of pyridostigmine or huperzine to primates: Compared efficacy against soman toxicity. Drug and Chemical Toxicology 2002; 25(-3-):309-320. >>> Pyridostigmine; huperzine; SC; Monkey; 2ML1; 6 days; Enzyme inhibitor (acetylcholinesterase); toxicology.

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

P5417 Weckbecker,G., Briner,U., Lewis,I., Bruns,C. SOM230: A new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs. Endocrinology 2002; 143(-10-):4123-4130. >>> Octreotide; SOM230; Water, sterile; SC; Rat; monkey; dog; 2002; 2ML1; 2ML2; 7, 14, or 56 days; Controls received mp w/ vehicle; functionality of mp verified by IGF-I plasma levels; long-term study, pumps replaced every 2 weeks; peptides; Somatostatin analogs; 2002 pumps used in rats; 2ML2 used in monkeys; 2ML1 pumps used in dogs; octreotide also called SMS 201-995.

P5348 Macdonald,R.L., Zhang,Z.D., Curry,D., Elas,M., Aihara,Y., Halpern,H., Jahromi,B.S., Johns,L. Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery 2002; 51(-3-):761-768. >>> Nitroprusside, sodium; Dextrose; water; CSF/CNS (subarachnoid, intrathecal); Monkey (cynomolgus); 7 days; Multiple pumps per animal (2); pumps connected to fenestrated catheter tubing placed between the right cerebral arteries and alongside a subarachnoid clot; drug stable for 7 days at 37C.

P5319 Ramachandra,S.G., Ramesh,V., Krishnamurthy,H.N., Kumar,N., Sundaram,K., Hardy,M.P., Rao,A.J. Effect of chronic administration of 7 alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata). REPRODUCTION 2002; 124(-2-):301-309. >>> Heparin, porcine; Saline; IV (femoral); Monkey (baboon); 195 days; Controls received mp w/ vehicle; pumps replaced after 28 days; cardiovascular; multiple pumps per animal (2).

P4851 Marshall,J.W.B., Duffin,K.J., Green,A.R., Ridley,R.R. NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001; 32(--):190-198. >>> NXY-059; Saline; SC; monkey (marmoset); 2001D; 48 hours; controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; pumps replaced after 24 hours; NXY-059 is a novel free-radical trapping agent; multiple pumps per animal (2) used simultaneously; ischemia (cerebral).

P4779 Howell,L.L., Schama,K.F., Ellis,J.E., Grimley,P.J., Kitchens,A.J., Byrd,L.D. Fetal development in rhesus monkeys exposed prenatally to cocaine.. Neurotoxicol.Teratol. 2001; 23(--):133-140. >>> Cocaine;; Saline;; SC;; monkey (pregnant);; 2ML4;; ~ 180 days;; Controls received mp w/ vehicle; functionality of mp verified by cocaine serum levels; dose-response (table 4 p. 136); long-term study, pumps replaced every 28 days for up to 180 days (until birth); teratology;.

P4671 Wilson,M.E. Insulin-like growth factor I (IGF-I) replacement during growth hormone receptor antagonism normalizes serum IGF-binding protein-3 and markers of bone formation in ovariectomized Rhesus monkeys.. J.Clin.Endocrinol.Metab. 2000; 85(-4-):1557-1562. >>> Insulin-like growth factor I; SC;; monkey;; 5 days;; functionality of mp verified by IGF-I plasma levels by RIA; replacement therapy (ovariectomy);.

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