References on the Administration of Agents to Primates Using ALZET® Osmotic Pumps

1. Baboon

11822 Sherwin, J.R.A., Hastings, J.M., Jackson, K.S., Mavrogianis, P.A., Sharkey, A.M., Fazleabas, A.T. The Endometrial Response to Chorionic Gonadotropin Is Blunted in a Baboon Model of Endometriosis. Endocrinology 2010; 151(-10-):4982-4993. >>> Gonadotrophin, human chorionic, recomb.; Saline; SC; intrauterine; Monkey (baboon); 2ML1; Animal info (30 mo old, spontaneous endometriosis); tissue perfusion (oviductal lumen).

11788 Sunderland, N.S., Thomson, S.E., Heffernan, S.J., Lim, S., Thompson, J., Ogle, R., McKenzie, P., Kirwan, P.J., Makris, A., Hennessy, A. Tumor necrosis factor alpha induces a model of preeclampsia in pregnant baboons (Papio hamadryas). Cytokine 2011; 56(-2-):192-199. >>> Tumor necrosis factor-alpha; PBS; IV (femoral); Monkey (pregnant, baboon); 2ML4; Controls received mp w/ vehicle; animal info (female, baboon, Papio hamadryas).

11273 Brosens, J.J., Hodgetts, A., Feroze-Zaidi, F., Sherwin, J.R.A., Fusi, L., Salker, M.S., Higham, J., Rose, G.L., Kajihara, T., Young, S.L., Lessey, B.A., Henriet, P., Langford, P.R., Fazleabas, A.T. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. MOLECULAR HUMAN REPRODUCTION 2010; 16(-4-):273-285. >>> Gonadotrophin, human chorionic, recomb.; Oviductal; Monkey (baboon); Animal info (cycling, female, 7-12 years old, 12-18 kg); tissue perfusion (oviduct).

10483 Evans, J., Catalano, R.D., Brown, P., Sherwin, R., Critchley, H.O.D., Fazleabas, A.T., Jabbour, H.N. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB Journal 2009; 23(-7-):2165-2175. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); Animal info (papio annubis).

10234 Fujimura, Y., Zoghbi, S.S., Simeon, F., Taku, A., Victor, P., Innis, R., Fujita, M. Quantification of peripheral benzodiazepine receptors in human brain with 18F-PBR06. Journal of Cerebral Blood Flow and Metabolism 2010; 29(--):S360-S375. >>> Nicotine; Monkey (baboon); Long-term study; animal info (Papio anubis); functionality of mp verified by plasma nicotine concentration; pumps replaced at 15 days, 2, 3, 4 and 5 months.

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2. Baboons

Q1551 Sherwin,J.R.A., Hastings,J.M., Jackson,K.S., Mavrogianis,P.A., Sharkey,A.M., Fazleabas,A.T. The Endometrial Response to Chorionic Gonadotropin Is Blunted in a Baboon Model of Endometriosis. Endocrinology 2010; 151(-10-):4982-4993. >>> Gonadotrophin, human chorionic, recomb.; Saline; SC; intrauterine; Monkey (baboon); 2ML1; ; Animal info (30 mo old, spontaneous endometriosis); tissue perfusion (oviductal lumen).

Q1517 Sunderland,N.S., Thomson,S.E., Heffernan,S.J., Lim,S., Thompson,J., Ogle,R., McKenzie,P., Kirwan,P.J., Makris,A., Hennessy,A. Tumor necrosis factor alpha induces a model of preeclampsia in pregnant baboons (Papio hamadryas). Cytokine 2011; 56(-2-):192-199. >>> Tumor necrosis factor-alpha; PBS; IV (femoral); Monkey (pregnant, baboon); 2ML4; ; Controls received mp w/ vehicle; animal info (female, baboon, Papio hamadryas).

Q1005 Brosens,J.J., Hodgetts,A., Feroze-Zaidi,F., Sherwin,J.R.A., Fusi,L., Salker,M.S., Higham,J., Rose,G.L., Kajihara,T., Young,S.L., Lessey,B.A., Henriet,P., Langford,P.R., Fazleabas,A.T. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. MOLECULAR HUMAN REPRODUCTION 2010; 16(-4-):273-285. >>> Chorionic gonadotrophin, human, recomb.; Oviductal; Monkey (baboon); 5 days; Animal info (cycling, female, 7-12 years old, 12-18 kg); tissue perfusion (oviduct).

Q0235 Evans,J., Catalano,R.D., Brown,P., Sherwin,R., Critchley,H.O.D., Fazleabas,A.T., Jabbour,H.N. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB Journal 2009; 23(-7-):2165-2175. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); 5 days; Animal info (papio annubis).

Q0042 Fujimura,Y., Zoghbi,S.S., Simeon,F., Taku,A., Victor,P., Innis,R., Fujita,M. Quantification of peripheral benzodiazepine receptors in human brain with 18F-PBR06. Journal of Cerebral Blood Flow and Metabolism 2010; 29(--):S360-S375. >>> Nicotine; Monkey (baboon); 6 months; Long-term study; animal info (Papio anubis); functionality of mp verified by plasma nicotine concentration; pumps replaced at 15 days, 2, 3, 4 and 5 months.

P9110 Banaszak,S., Brudney,A., Donnelly,K., Chai,D., Chwalisz,K., Fazleabas,A.T. Modulation of the action of chorionic gonadotropin in the baboon (Papio anubis) uterus by a progesterone receptor antagonist (ZK 137. 316). Biol.Reprod. 2000/9; 63(-3-):820-825. >>> Gonadotrophin, human chorionic; Intraovarian; Monkey (baboon); 4 days; Animal info (ovariectomized).

P8047 Sherwin,J.R.A., Sharkey,A.M., Cameo,P., Mavrogianis,P.M., Catalano,R.D., Edassery,S., Fazleabas,A.T. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148(-2-):618-626. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); 5 days; Animal info (female, adult).

P7516 Strakova,Z., Mavrogianis,P., Meng,X.M., Hastings,J.M., Jackson,K.S., Cameo,P., Brudney,A., Knight,O., Fazleabas,A.T. In vivo infusion of interleukin-1 beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon. Endocrinology 2005; 146(-9-):4097-4104. >>> Gonadotrophin, human chorionic, recomb.; interleukin-1, beta, recomb. human; interleukin-1 receptor antagonist, recomb. human; Oviductal; Monkey (baboon); 10 days; Controls received no treatment; pumps replaced at day 5; animal info (female, adult).

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

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3. Marmoset

12391 Kitamura, K., Fujiyoshi, K., Yamane, J., Toyota, F., Hikishima, K., Nomura, T., Funakoshi, H., Nakamura, T., Aoki, M., Toyama, Y., Okano, H., Nakamura, M. Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury. PLoS One 2011; 6(-11-):U83-U95. >>> Hepatocyte growth factor, recomb. human; PBS; CSF/CNS (intrathecal); Monkey (marmoset); 2004; Controls received mp w/ vehicle; animal info (adult, female, common, 295-350 g); ALZET rat intrathecal catheter used.

10764 Ziegler, T.E., Prudom, S.L., Zahed, S.R., Parlow, A.F., Wegner, F. Prolactin's mediative role in male parenting in parentally experienced marmosets (Callithrix jacchus). Hormones and Behavior 2009; 56(-4-):436-443. >>> Prolactin, human, recomb.; Glycerol; NaHCO3; NaCl; SC; Monkey (marmoset); 2004; Controls received mp w/ saline; animal info (2.5-9 yrs old, male, parentally experienced);"... these pellets (from Innovative Research of America) did not raise the level of prolactin in the blood over the level of our control parentally experienced fathers... Therefore, we chose to use the osmotic minipump (Alzet, CA) for our test males."pg 439;"The position of the pumps on the lower area of a male's back precluded any interference with infant carrying since infant carrying occurs nearer the neck"pg 439; comparison of pellets vs mp.

10698 Stockwell, K.A., Scheller, D., Rose, S., Jackson, M.J., Tayarani-Binazir, K., Iravani, M.M., Smith, L.A., Olanow, C.W., Jenner, P. Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. Experimental Neurology 2009; 219(-2-):533-542. >>> Rotigotine; Saline, sterile; SC; Monkey (marmoset); 2004; Controls received mp w/ vehicle; animal info (adult common, male, female, 354 g); comparison of sc injections vs. mp; neurodegenerative (Parkinson's disease); post op. care (Rimadyl, Synulox);"pumps were removed... and replaced with new minipumps implanted into the opposite flank."pg 534;"These results demonstrate that the anti-parkinsonian benefits associated with a continuous infusion of rotigotine were more sustained compared to pulsatile rotigotine or L-DOPA treatment..."pg 541; long-term study.

10273 Stockwell, K.A., Scheller, D.K.A., Smith, L.A., Rose, S., Iravani, M.M., Jackson, M.J., Jenner, P. Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets. Experimental Neurology 2010; 221(-1-):79-85. >>> Rotigotine hydrochloride; DMSO; water, sterile; SC; Marmoset; 2004; Comparison of SC injections or PO administration vs. SC mp; animal info (adult, common, male, female, 2-7 years old, 350-500); 50% DMSO used;"These data suggest that dyskinesia induced by pulsatile drug treatment may be improved by switching to continuous rotigotine delivery."pg. 79;"...this study highlights the potential benefits of continuous drug delivery."pg 84.

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4. Monkey

16214 Morin, N., Morissette, M., Gregoire, L., Rajput, A., Rajput, A. H., Di Paolo, T. Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications. Neuropharmacology 2015; 99(--):356-68. >>> MPTP; Saline; SC; Monkey (macaque); Controls received no treatment; animal info (drug naive female ovariectomized monkeys (Macaca fascicularis) (aged 4.7e7.7 y; weight: 2.7e4.2 kg;); functionality of mp verified by observation for disability signs; neurodegenerative (Parkinson’s Disease); behavioral testing (disability testing); MPTP - neurotoxin; Dose (0.5 mg/24 h);.

15208 Cunningham, C.S., Moerke, M.J., McMahon, L.R., McMahon, L.R. The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys1734. BEHAVIOURAL PHARMACOLOGY 2014; 25(--):296-305. >>> Nicotine; Saline; SC; Monkey (Rhesus); 2ML4; Controls received mp w/ vehicle; animal info (Macaca mulatta, rhesus monkey, adult); pumps replaced every 28 days; behavioral testing (stimulus-shock termination);.

14308 Morin, N., Morissette, M., Gregoire, L., Di Paolo, T., Di Paolo, T. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2015; 56(--):27-38. >>> MPTP; Saline; SC; Monkey (macaque); Controls received mp w/ vehicle; animal info (female, Macaca fascicularis, ovariectomized, 4.7-7.7 years old, 2.7-4.2kg); long-term study; neurodegenerative (Parkinson's disease);.

14285 Lo, J.O., Schabel, M.C., Roberts, V.H.J., Morgan, T.K., Rasanen, J.P., Kroenke, C.D., Shoemaker, S.R., Spindel, E.R., Frias, A.E., Lo, J.O. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. American Journal of Obstetrics and Gynecology 2015; 212(--):U271-U278. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Monkey (macaque, pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Rhesus, pregnant, GD26); functionality of mp verified by blood levels; pumps replaced every 3 weeks; post op. care (cefazolin 150 mg BID); long-term study; teratology; dependence;.

14730 Elsworth, J.D., Jentsch, J.D., Groman, S.M., Roth, R.H., Redmond, DE Jr, Leranth, C., Elsworth, J.D. Low Circulating Levels of Bisphenol-A Induce Cognitive Deficits and Loss of Asymmetric Spine Synapses in Dorsolateral Prefrontal Cortex and Hippocampus of Adult Male Monkeys. Journal of Comparative Neurology 2015; 523(--):1248-1257. >>> Bisphenol A, deuterium-labeled; SC; Monkey; 2ML4; Controls received mp w/ vehicle; animal info (male, St, Kitts African vervet S. sabaeus, young); functionality of mp verified by plasma levels; behavioral testing (working memory performance); toxicology;"we administered BPA from a subcutaneous minipump that ensured a constant and reliable delivery of BPA"pg 1249; pumps removed after 30 days;.

14715 Dugan, L.L., Tian, L.L., Quick, K.L., Hardt, J.I., Karimi, M., Brown, C., Loftin, S., Flores, H., Moerlein, S.M., Polich, J., Tabbal, S.D., Mink, J.W., Perlmutter, J.S., Perlmutter, J.S. Carboxyfullerene Neuroprotection Postinjury in Parkinsonian Nonhuman Primates. Annals of Neurology 2014; 76(--):393-402. >>> C3; SC; IP; Monkey (macaque); 2ML4; Controls received mp w/ placebo; animal info (Macaca facicularis); Multiple pumps per animal (2); neurodegenerative (Parkinson's disease); behavioral testing (locomotor activity); stability verified by (testing at 37C, C3 is stable for>40 days); Carboxyfullerine aka C3;.

14675 Braunger, B.M., Ademoglu, B., Koschade, S.E., Fuchshofer, R., Gabelt, B.T., Kiland, J.A., Hennes-Beann, E.A., Brunner, K.G., Kaufman, P.L., Tamm, E.R., Tamm, E.R. Identification of Adult Stem Cells in Schwalbe's Line Region of the Primate Eye. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2014; 55(--):7499-7507. >>> Uridine, bromodeoxy-; SC; Monkey (macaque); 2ML4; Animal info (Macaca fascicularis); pumps removed after 4 weeks;.

14604 Negishi, T., Nakagami, A., Kawasaki, K., Nishida, Y., Ihara, T., Kuroda, Y., Tashiro, T., Koyama, T., Yoshikawa, Y., Negishi, T. Altered social interactions in male juvenile cynomolgus monkeys prenatally exposed to bisphenol A. NEUROTOXICOLOGY AND TERATOLOGY 2014; 44(--):46-52. >>> Bisphenol A; DMA; PEG; SC; Monkey (pregnant); 2004; Control animals received mp w/ vehicle; animal info (cynomolgus, 2.5-4.0 kg, 5-13 years old, GD20);"We administered BPA in pregnant females on gestational day 20 at 10µg/kg/day through pumps implanted to produce an exposure regimen with a steady level of circulating BPA without the stress of daily restraint essential for oral administration."pg 50; teratology; 50% DMA used; 50% PEG used.

13872 Morin, N., Jourdain, V.A., Morissette, M., Gregoire, L., Di Paolo, T. Long-term treatment with L-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys. Neuropharmacology 2014; 79(-;-):688-706. >>> MPTP; Saline; SC; Monkey (Macaca fascicularis); Controls received mp w/ vehicle; animal info (female, OVX, 4.7-7.7 years old, 2.7-4.2 kg); neurodegenerative (Parkinson's); long-term study; MPTP aka 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; monkeys treated until parkinsonian features were achieved;.

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What researchers are saying ...

“Several approaches have been tested to improve the anti-tumor activity of cytotoxins and immunotoxins and to decrease toxicity and immunogenicity of these agents.”... “In our current study, we utilized a device for continuous infusion (ALZET pump) of drug as an alternate approach to increase the availability of drug. This approach resulted in improved anti-tumor effect and decreased toxic effects.” “Utilizing this device, IL-13 cytotoxin can be continuously administered systemically in body.” Kawakami et al., Molecular Medicine 2002;8(8):487-494.