References on the Administration of Progesterone Using ALZET^® Osmotic Pumps

P8245 Lefter,R., Morency,C.E., Joseph,V. Progesterone increases hypoxic ventilatory response and reduces apneas in newborn rats. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2007; 156(-1-):9-16. >>> Progesterone; Propylene glycol; SC; Rat (lactating); 2ML2; 9 days; Controls received mp w/ vehicle; animal info (female, postnatal day 1, lactating); "This approach ensures adequate hormonal exposure in pups since steroids are excreted through the milk, and prevents the potential confounding influences of pup's manipulation on respiratory or metabolic variables." (p. 14).

P7200 Robichaud,M., Debonnel,G. Oestrogen and testosterone modulate the firing activity of dorsal raphe nucleus serotonergic neurones in both male and female rats. Journal of Neuroendocrinology 2005; 17(-3-):179-185. >>> Estradiol, 17B-; testosterone; progesterone; pregnane-3, 20 dione, 5B-; pregnane-3a-ol, 20-one, 5a-; dehydroepiandrosterone; testosterone, 5a-dihydroxy; Ethanol; water, distilled; CSF/CNS; Rat; 2ML1; 3, 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; 3% ethanol; animal info (Sprague-Dawley, 250-325 g).

P7097 Robichaud,M., Debonnel,G. Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. Journal of Endocrinology 2004; 182(-1-):11-21. >>> NE-100; progesterone; pregnenolone; dehydroepiandrosterone; pregnane -3,20-dione, 5B; pregnane -3-ol,20-one, 5a; pregnane -3,20-dione, 5a; pregnane -5B-ol,20-one, 3a; pregnane -3B-ol,20-one, 5B; pregnane -3B-ol,20-one, 5a; Water, distilled; ethanol; SC; CSF/CNS; Rat; 7,14,21 days; Controls received mp w/ vehicle, or saline; replacement therapy (ovariectomy); NE-100 is N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy) phenyl)-ethylamine; allopregnanolone; DHP and THP metabolite stereoisomers.

P6581 Pazol,K., Wilson,M.E., Wallen,K. Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female macaques. Journal of Clinical Endocrinology and Metabolism 2004; 89(-6-):2998-3006. >>> Progesterone acetate, medroxy-; progesterone; DMSO; SC; Monkey; 2ML1; 1 week; Controls received placebo; functionality of mp verified by serum hormone levels; replacement therapy (ovariectomy); pumps replaced animals received mp w/ agent 1 for 1 week, mp removed, 3 week washout period and then new mp w/ agent 2 for 1 week; peptides.

P6480 Traish,A.M., Kim,N.N., Huang,Y.H., Min,K., Munarriz,R., Goldstein,I. Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vagina. International Journal of Impotence Research 2003; 15(-6-):397-404. >>> Testosterone; dehydroepiandrosterone; dihydrotestosterone, 5-alpha-; androstenediol, delta 5-3B, 17B; estradiol; progesterone; PEG; SC; Rabbit; 2002; 2 weeks; Controls received mp w/ vehicle; replacement therapy (ovariectomy); multiple pumps per animal (2).

P5927 Shao,T.C., Li,H.L., Eid,W., Ittmann,M., Unni,E., Cunningham,G.R. In vivo preservation of steroid specificity in CWR22 xenografts having a mutated androgen receptor. PROSTATE 2003; 57(-1-):1-7. >>> Testosterone; estradiol; progesterone; flutamide; Cylodextrin, 2-beta-hydroxypropl; SC; Mice (nude); 2004; 4 weeks; Replacement therapy (castration); cancer (prostate); CWR22 xenograft used; flutamide is an anti-androgen; animal info (5-6 week old, nude ,ORX).

P5305 Gomez-Sanchez,E.P., Gomez-Sanchez,C.E. Maternal hypertension and progeny blood pressure: role of aldosterone and 11beta-HSD. Hypertension 1999/6; 33(-6-):1369-1373. >>> Aldosterone; Hydroxyprogesterone, 11a; Carbenolone; SC; CSF/CNS; Rat (pregnant); 2002; 2004; 14, 28 days; Controls received mp w/ vehicle; stress/adverse reaction (p.1370); seroma around pump assembly in systemic carbenolone and hydroxyprogesterone high dose groups; some pumps became disconnected from cannula; glucocorticoids; comparison of sc vs. icv infusion.

P4635 Zhang,L., Fishman,M.C, Huang,P.L  Arterioscler.Thromb.Vasc.Biol. 1999; 19(--):2059-2065. >>> Estradiol, 17B-; Progesterone; Gonadotrophin, human chorionic; SC; Mice; 2002; 14 days; Controls received sham operation; functionality of mp verified by serum levels; replacement therapy (ovariectomy); vascular cuff injury; B human chorionic gonadotrophin used;.

P4144 Souness,G.W., Morris,D.J. 11a- and 11b- hydroxyprogesterone, potent inhibitors of 11b-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension 1996; 27(-pt 1-):421-425. >>> Progesterone, 11a; Hydroxyprogesterone, 11b; RU-28318; Corticosterone; Propylene glycol; SC; rat; 2002; 14 days; controls received mp w/vehicle; functionality of mp verified by residual volume; replacement therapy (adrenalectomy); agents infused singly and concomitantly in same pump; cardiovascular.

P3698 Nolan,C., Proietto,J. The effects of oophorectomy and female sex steroids on glucose kinetics in the rat. Diabetes Res.Clin.Pract. 1995; 30(--):181-188. >>> Estradiol, 17B-; Progesterone; Propylene glycol; SC; rat; 2ML1; 7 days; controls received sham oophorectomy and/or mp w/ vehicle; replacement therapy (oophorectomy).

P3238 Lobo,M.J., Remesar,X., Alemany,M. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem.Molec.Biol.Intl. 1993; 29(-2-):349-358. >>> Progesterone; Cortisol; Cortisone; Corticosterone; Dehydroepiandrosterone; Androstenedione, 4-; Androstendiol, 5-; Testosterone; Nortestosterone, 19-; Estradiol, B-; Estrone; Estriol; Deoxycorticosterone; PEG 400; IV (lower cava); rat; 2002; 15 days; controls received mp with PEG; no stress (see pg. 351); pumps placed into peritoneal cavity and sutured to musculature; surgical wound sprinkled with sulphathiazol.

P3233 Lee,M.-Y., Clark,J.E., Williams,D.E. Induction of flavin-containing monooxygenase (FMO B) in rabbit lung and kidney by sex steroids and glucocorticoids. Archives Biochem.Biophys. 1993; 302(-2-):332-336. >>> Estradiol, B-; Progesterone; Propylene glycol; Ethanol; Ascorbic acid; IP; rabbit; 2001; 4-5 days; controls received mp w/pg; functionality of mp verified by plasma levels; comparison of injections vs. mp.

P1852 Dauvois,S., Geng,C.-S., Levesque,C., Merand,Y., Labrie,F. Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice. Cancer Res. 1991; 51(--):3131-3135. >>> EM-170; Progesterone acetate, medroxy-; DMSO; mice; 40 days; replacement therapy (ovariectomy); long-term study, pumps replaced every 20 days; cancer; antiestrogen.

P1697 Mukai,S., Mori,Y., Nagashima,H., Hasegawa,Y., Hoshino,K. Changes in plasma gonadotropins, ovarian steroids and inhibin concentrations in gilts following progesterone treatment with implantable osmotic pumps. Anim.Reprod.Sci. 1989; 20(--):287-297. >>> Progesterone; Ethanol; propylene glycol; SC; Pig; 2ML1; 7 days; Multiple pumps per animal (12); "implanted pumps effectively suppressed follicular growth" (p. 296).

P1271 Hatjis,C.G., Koritnik,D.R., Crews,A. Up-regulation of guinea pig myometrial b-adrenoreceptors by systemic estradiol and progesterone. Endocrinology 1988; 122(-4-):1455-1459. >>> Estradiol, 17B-; Progesterone; Propylene glycol; guinea-pig; 7 days; Pump model not stated; controls received mp w/vehicle; separate and simultaneous infusion of agents; replacement therapy (oophorectomy).

P0566 Will,P.C., Cortright,R.N., DeLisle,R.C., Douglas,J.G., Hopfer,U. Regulation of amiloride-sensitive electrogenic sodium transport in the rat colon by steroid hormones. Am.J.Physiol. 1985; 248(-1-):G124-G132. >>> Aldosterone; Corticosterone; Dexamethasone phosphate; Estradiol, 17B-; Progesterone; Testosterone; PEG 400; PEG 600; IP; rat; 1701; 2001; 3-8 days; comparison of agents effects; replacement therapy (adrenalectomy&ovariectomy); controls received mp with solvent or glass rods of mp size; no stress implied G125, weight regained; functionality of mp verified.

P1224 Lavia,L.A., Shideler,C., Farley,N., Walker,N., Fields,W., Roberts,D.K. Uterine growth responses of the mature castrate rat to estradiol-17B. Steroids 1984; 43(-6-):663-675. >>> Estradiol, 17B-; Progesterone; SC; rat; 2001; 24 hours; separate and simultaneous infusion of agents; 2 doses of E2 infused; functionality of mp verified by radioimmunoassay.

P0498 Bochskanl,R., Thie,M., Kirchner,C. Progesterone dependent uptake of uteroglobin by rabbit endometrium. Histochemistry 1984; 80(--):581-589. >>> Progesterone; IP; rabbit; 2ML1; no duration posted; replacement therapy (ovariectomy).

P0238 Jellinck,P.H., Luine,V., McEwen,B.S. Differential effects of catechol estrogens, progestins and CI-628 administered by constant infusion on the central and peripheral action of estradiol. Neuroendocrinology 1982; 35(--):73-78. >>> CI-628; Progestins; R-5020; Catecholestrogens; Estradiol, 17B-; Progesterone; Ascorbic acid; PEG; SC; rat; 2001; 2-3 days; organ replacement therapy (ovariectomy); agents used alone and/or in combination; Cl-628 is an anti-estrogen; R-5020 is a progestin.

P0161 Komanicky,P., Melby,J.C. Experimental hypertension induced by 19-nor-progesterone treatment in the rat. Endocrinology 1981; 109(-4-):1164-1167. >>> Aldosterone acetate; Progesterone, 19-nor-; Ethanol; Propylene glycol; Water; SC; rat; 1701; no duration posted; pumps replaced after 7 and 14 days.

P0146 Bochskanl,R., Kirchner,C. Uteroglobin and the accumulation of progesterone in the uterine lumen of the rabbit. Wilhelm Roux's Archives 1981; 190(--):127-131. >>> Progesterone; Ethanol; Propylene glycol; IP; rabbit; 2001; 4 days; organ replacement therapy (ovariectomy); 1-2 pumps/animal.

P0061 Will,P.C., Cortright,R.N., Hopfer,U. Polyethylene glycols as solvents in implantable osmotic pumps. J.Pharm.Sci. 1980; 69(-6-):747-749. >>> Aldosterone; Corticosterone; Deoxycorticosterone acetate; Dexamethasone acetate; Estradiol, 17B-; Hydrocortisone; Progesterone; Spironolactone; Testosterone; PEG; PEG 400; PEG 600; IP; rat; 1701; no duration posted; 3-7 days aldosterone, 6 days PEG only; replacement therapy (adrenalectomy).

P0100 Cervantes,M., Ruelas,R., Beyer,C. Progesterone facilitation of EEG synchronization in response to milk drinking in female cats. Psychoneuroendocrinology 1979; 4(-3-):245-251. >>> Progesterone; Ethanol; Propylene glycol; SC; cat; 1701; 8 days; comparison of injections 2x/day vs. infusion; organ replacement therapy (ovariectomy).