References on the Administration of Prolactin Using ALZET^® Osmotic Pumps

R0089 Amkraut,A., Eckenhoff,J.B., Nichols,K. Osmotic delivery of peptides and macromolecules. Adv.Drug Delivery Review 1990; 4(--):255-276. >>> Atrial natriuretic factor; Cholecystokinin; Colony-stimulating factor, G.; Glucagon; Insulin; Interleukin-2; Interleukin-3; Melatonin; Nerve growth factor; Neurotensin; Prolactin; Theophylline; CSF/CNS; IA (femoral); intrasplenic; IP; SC; no duration posted; peptides; ALZA-authored, review of peptide delivery issues and applications; tissue perfusion (spleen).

R0046 Skett,P., Young,C. The effect of pituitary hormones on hepatic drug metabolism. In 'Biochemistry, Biophysics and Regulation of Cytochrome P-450,' J.-A.Gustafsson, J.Carlstedt-Duke, A.Mode, and J.Rafter (eds.), Elsevier/North-Holland, Amsterdam 1980; (--):195-198. >>> Enkephalin analog DADLE; Follicle stimulating hormone; Growth hormone, bovine; Growth hormone, rat; Pituitary extract; Prolactin, bovine; Prolactin, rat; Thyroid-stimulating hormone; Water; SC; rat; 1701; 1 week; peptides.

P8839 Augustine,R.A., Grattan,D.R. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology 2008; 149(-3-):1049-1055. >>> Prolactin, ovine; CSF, artificial; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (female, Sprague Dawley, 10 wks old, 200-300g., pseudopregnant); endocrinology.

P8809 Naef,L., Woodside,B. Prolactin/Leptin interactions in the control of food intake in rats. Endocrinology 2007; 148(-12-):5977-5983. >>> Prolactin, ovine; NaHCO3; HCl; CSF/CNS; Rat; 2001; 2002; 7, 10 days; Controls received mp w/ vehicle; dose-response (Fig. 1); peptides; animal info (female, Wistar, 220-240g.).

P8681 Grattan,D.R., Jasoni,C.L., Liu,X.H., Anderson,G.M., Herbison,A.E. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology 2007; 148(-9-):4344-4351. >>> Prolactin, ovine; CSF/CNS; Mice; 1002; 7 days; Serum levels taken, peptides, animal info (adult, female, C57BL6/J, 6-8 weeks, 24-28g, OVX).

P8503 Williams,V.L., DeGuzman,A., Dang,H., Kawaminami,M., Ho,T.W.C., Carter,D.G., Walker,A.M. Common and specific effects of the two major forms of prolactin in the rat testis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 293(-6-):E1795-E1803. >>> Prolactin; Saline; SC; Rat; 4 weeks; Controls received mp w/ vehicle; plasma levels taken; peptides; animal info (male).

P8425 Gregg,C., Shikar,V., Larsen,P., Mak,G., Chojnacki,A., Yong,V.W., Weiss,S. White matter plasticity and enhanced remyelination in the maternal CNS. Journal of Neuroscience 2007; 27(-8-):1812-1823. >>> Prolactin, recomb. mouse; Saline; albumin mouse serum; SC; Mice; 1007D; 2.5 days; Controls received mp w/ vehicle; peptides; animal info (female, CD-1, 6-8 wks old).

P8230 Craven,A.J., Nixon,A.J., Ashby,M.G., Ormandy,C.J., Blazek,K., Wilkins,R.J., Pearson,A.J. Prolactin delays hair regrowth in mice. Journal of Endocrinology 2006; 191(-2-):415-425. >>> Prolactin, ovine; domperidone; Sodium bicarbonate buffer; PEG 400; SC; Mice; 1003D; 1007D; 1002; 3, 12, 14, days; Controls received no treatment; functionality of mp verified by plasma prolactin levels; animal info (Balb/c, 18-30 days old).

P8083 Hilfiker-Kleiner,D., Kaminski,K., Podewski,E., Bonda,T., Schaefer,A., Sliwa,K., Forster,O., Quint,A., Landmesser,U., Doerries,C., Luchtefeld,M., Poli,V., Schneider,M.D., Balligand,J.L., Desjardins,F., Ansari,A., Struman,I., Nguyen,N.Q.N., Zschemisch,N.H., Klein,G., Heusch,G., Schulz,R., Hilfiker,A., Drexler,H. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 2007; 128(-3-):589-600. >>> Prolactin, recomb; Mice; 3 weeks; Controls received mp w/ saline; cardiovascular; peptides; animal info (female).

P7705 Combs,T.P., Berg,A.H., Rajala,M.W., Klebanov,S., Iyengar,P., Jimenez-Chillaron,J.C., Patti,M.E., Klein,S.L., Weinstein,R.S., Scherer,P.E. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003/2; 52(-2-):268-276. >>> Prolactin; bromocriptine; SC; Mice; 1007D; 3 days; Animal info (female, C57BL/6J).

P7665 Guzman,E.A., Chen,Y.H., Langowski,J.L., De Guzman,A., Lo,H.L., Walter,B., Muller,H.K., Walker,A.M., Owen,L.B. Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. Journal of Neuroimmunology 2005; 170(-1-2-):31-40. >>> Prolactin, recomb.; prolactin, S179D; Saline; SC; Mice; 2004; 21 days; Controls received mp w/ vehicle; immunology; animal info (male, C3H/HeJ or C3H/HeJ-TnFsF6gld, 10-12 wk. old).

P7620 Obal,F.Jr, Garcia-Garcia,F., Kacsoh,B., Taishi,P., Bohnet,S., Horseman,N.D., Krueger,J.M. Rapid eye movement sleep is reduced in prolactin-deficient mice. Journal of Neuroscience 2005; 25(-44-):10282-10289. >>> Prolactin, murine; Saline, physiological; SC; Mice; 1002; 11-12 days; Controls received mp w/ vehicle; animal info (C57BL/6J, pRL, KO, male, 25-30 g, 8-16 wk old).

P7450 Leonard,S.T., izadeh-Naderi,R., Stokes,K., Ferkin,M.H. The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. PHYSIOLOGY&BEHAVIOR 2005; 85(-4-):461-468. >>> Bromocriptine; prolactin, ovine; Saline, sterile; SC; Prairie vole; 2004; ; Controls received mp w/ vehicle; replacement therapy (gonadectomy); animal info (male, meadow); animals also received testosterone via silastic implant at same time.

P7199 Nasir,I., Kedees,M.H., Ehrlich,M.E., Teitelman,G. The role of pregnancy hormones in the regulation of Pdx-1 expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2005; 233(-1-2-):1-13. >>> Prolactin, bovine; NaHCO3; SC; Mice; 2001; 4.5 days; Controls received mp w/ vehicle; functionality of mp verified by serum bPRL levels; peptides; multiple pumps per animal (2).

P7044 Auchtung,T.L., Dahl,G.E. Prolactin mediates photoperiodic immune enhancement: Effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers. Biology of Reproduction 2004; 71(-6-):1913-1918. >>> Prolactin, recomb. bovine; Saline; SC; Cattle; 2ML2; 10 days; Comparison of IV injections vs mp; no stress ( see pg. 1914); immunology; peptides; post op. care (prodine, excenel); each animal received 4 rounds of 10 day prolactin treatment (2 w/ mp, 2 IV injection) with 11 days of non treatment between each round.

P6603 Xu,X.L., Wu,W., Williams,V., Khong,A., Chen,Y.H., Deng,C.H., Walker,A.M. Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate. PROSTATE 2003; 54(-1-):25-33. >>> Prolactin, human recomb.; prolactin, S179D; Saline; SC; Rat; 2004; 3 weeks; Comparison of SC injections vs. mp; peptides.

P6301 Payne,A.P., Shah,S.W., Marr,F.A., McGadey,J., Thompson,G.G., Moore,M.R. Hormones and the Control of Porphyrin Biosynthesis and Structure in the Hamster Harderian Gland. Microscopy Res.and Tech. 1996; 34(--):123-132. >>> Bromocriptine; prolactin; Hamster; ; Replacement therpay (castration, ovariectomy); multiple pumps per animal (2).

P5810 Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C., Arons,S., Iversen,A.K., Looman,C., Jensen,H.E., Hau,J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Prolactin; Saline; SC; Rat (pregnant); 2001; 2004; 7 days; peptides; unmodified (u-PRL)&phosphorylated (p-PRL) prolactin used.

P5677 Nahi,F., Arbogast,L.A. Prolactin modulates hypothalamic preproenkephalin, but not proopiomelanocortin, gene expression during lactation. Endocrine 2003; 20(-1-2-):115-122. >>> Prolactin, ovine; Sodium bicarbonate; heparin; NaCl; IV (jugular); Rat; ; Controls received mp w/ vehicle; half-life = 6 hours (p.119); peptides; heparin dose 50 U/ml.

P5460 Kuo,C.B., Wu,W., Xu,X.L., Yang,L.L., Chen,C., Coss,D., Birdsall,B., Nasseri,D., Walker,A.M. Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell and Tissue Research 2002; 309(-3-):429-437. >>> Prolactin, S179D; Saline; SC; Rat; 2001; 2004; 28 days.

P5410 Yang,L., Lii,S., Kuo,B., Buckley,A., Buckley,D., Chen,C., Xu,X.L., Coss,D., Walker,A.M. Maternal prolactin composition can permanently affect epidermal gamma delta T cell function in the offspring. Developmental and Comparative Immunology 2002; 26(-9-):849-860. >>> Prolactin, recomb; prolactin, phosphorylated; Saline; Rat (pregnant); 2002; ; Controls received mp w/ vehicle; teratology; peptides; apoptosis.

P5239 Sockman,K.W., Schwabl,H., Sharp,P.J. The role of prolactin in the regulation of clutch size and onset of incubation behavior in the American kestrel. Horm.Behav. 2000/11; 38(-3-):168-176. >>> Prolactin, ovine; NaCO3; NaCl; SC; Bird (kestrel); 1002; 15 days; Controls received mp w/ vehicle; prolactin plasma levels checked; dose-response (p.173); 17 min. half-life (p.171).

P5143 Torner,L., Toschi,N., Nava,G., Clapp,C., Neumann,I.D. Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses. European Journal of Neuroscience 2002; 15(--):1381-1389. >>> Oligodeoxynucleotide, antisense; Prolactin, ovine; Ringer's solution; CSF/CNS; Rat (lactating); 1007D; 5 days; controls received mp w/ vehicle; antisense; oligonucleotides against the long form of the brain Prolactin receptor.

P4954 Torner,L., Toschi,N., Pohlinger,A., Landgraf,R., Neumann,I.D. Anxiolytic and anti-stress effects of brain prolactin: Improved efficacy of antisense targeting of the prolactin receptor by molecular modeling. Journal of Neuroscience 2001; 21(-9-):3207-3214. >>> Prolactin; S179D; SC; mice (nude); 2004; 5 days; controls received mp w/ vehicle; functionality of mp verified by plasma prolactin levels; peptides; cancer (prostate); S179D is a prolactin receptor antagonist; wild-type prolactin used..

P3807 Hedner,E., Linde,A., Nilsson,A. Systemically and locally administered growth hormone stimulates bone healing in combination with osteopromotive membranes: an experimental study in rats. J.Bone and Min.Res. 1996; 11(-12-):1952-1960. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; SC; bone (mandible); rat; 2, 3, 4 weeks; controls received mp w/saline; pumps replaced after 2 weeks; recomb. human and bovine GH used.

P3694 Wardlaw,S.L., Kim,J., Matera,C. Effect of chronic prolactin infusion on pituitary prolactin and hypothalamic proopiomelanocortin. J.Neuroendocrinology 1997; 9(--):81-85. >>> Prolactin, ovine; Phosphate buffer; SC; CSF/CNS (third ventricle); rat; 2001; 1 or 2 weeks; controls received mp w/ vehicle; ICV&SC pumps replaced after 7 days; peptides; solutions were millipore filtered; 1 sc mp replaced with 2 pumps after 7 days.

P3271 Maeda K.-I., Uchida,E., Tsukamura,H., Ohkura,N., Ohkura,S., Yokoyama,A. Prolactin does not mediate the suppressive effect of the suckling stimulus on luteinizing hormone secretion in ovariectomized lactating rats. Endocrinol.Japan 1990; 37(-3-):405-411. >>> Prolactin, ovine; SC; rat; 2001; no duration posted; pumps replaced after 8 days; peptides.

P3106 Tsukamura,H., Maeda,K.-I., Ohkura,S., Uchida,E., Yokoyama,A. The suppressing effect of the suckling stimulus on the pulsatile luteinizing hormone release is not mediated by prolactin in the rat at mid-lactation. Jpn.J.Animal Reprod. 1991; 37(-1-):59-63. >>> Prolactin, ovine; Sodium bicarbonate; Saline; SC; rat; 2001; no duration posted; peptides.

P3037 Myal,Y., Iwasiow,B., Yarmill,A., Harrison,E., Paterson,J.A., Shiu,R.P.C. Tissue-specific androgen-inhibited gene expression of a submaxillary gland protein, a rodent homolog of the human prolactin-inducible protein/GCDFP-15 gene. Endocrinology 1994; 135(-4-):1605-1610. >>> Prolactin, ovine; rat; 14 days; peptides.

P3008 Freyschuss,B., Sahlin,L., Masironi,B., Eriksson,H. The hormonal regulation of the oestrogen receptor in rat liver: an interplay involving growth hormone, thyroid hormones and glucocorticoids. J.Endocrinol. 1994; 142(--):285-298. >>> Growth hormone, human; Triiodothyronine, L-; Prolactin, ovine; Dexamethasone; SC; rat; 7 days; controls received hypophysectomy only w/ no mp; functionality of mp verified by checking pumps after usage; replacement therapy (hypophysectomy); comparison of single sc injections of GH&T3 vs. mp; agents given alone or in combination; growth hormone via mp partly restores liver estrogen receptor concentration while same dose in 2 single injections daily has no effect.

P2998 DiGregorio,G.B., Gonzalez Reyna,A., Murphy,B.D. Roles of melatonin and prolactin in testicular crudescence in mink (Mustela vison). J.Reprod.Fertil. 1994; 102(--):1-5. >>> Prolactin, ovine; SC; mink; 110 days; controls received no treatment; long-term study, pumps replaced every 4 weeks; peptides.

P2858 Pitts,G.R., Youngren,O.M., Silsby,J.L., Rozenboim,I., Chaiseha,Y., Phillips,R.E., Foster,D.N., El Halawani,M.E. Role of vasoactive intestinal peptide in the control of prolactin-induced turkey incubation behavior. II. Chronic infusion of vasoactive intestinal peptide. Biol.Reprod. 1994; 50(--):1350-1356. >>> Vasoactive intestinal peptide, porcine; Prolactin, ovine; Saline; Sodium bicarbonate; SC; CSF/CNS; CSF/CNS (median eminence); bird (turkey); 2001; 2002; 7, 10, 12 days; controls received mp with saline; functionality of mp verified by residual volume; stability of pVIP -- still potent after 17 days in sc pump; peptides; pumps implanted after recovery from CNS surgery.

P2591 Arbogast,L.A., Voogt,J.L. Pituitary adenylate cyclase-activating polypeptide (PACAP) increases prolactin release and tuberoinfundibular dopaminergic neuronal activity. Brain Research 1994; 655(--):17-24. >>> Prolactin, ovine; Sodium bicarbonate; Sodium chloride; Heparin; IV (jugular); rat; 2 days; functionality of mp verified by RIA of plasma levels; peptides; PACAP 38 or saline injections iv, concomitantly; 50 U/ml of heparin.

P2456 Katz,L.S., Nicoll,C.S. Evidence for a role of the liver in the luteotropic action of prolactin in rats. Biol.Reprod. 1993; 48(--):512-514. >>> Prolactin, ovine; Sodium azide; Sodium phosphate; Saline; Glycerol; IV (jugular); IV (hepatic portal); rat; 2002; no duration posted; pulsed delivery; peptides; air used in lynch coil.

P2422 Ruby,N.F., Nelson,R.J., Licht,P., Zucker,E. Prolactin and testosterone inhibit torpor in siberian hamsters. Am.J.Physiol. 1993; 264(-133-):R123-R128. >>> Prolactin, ovine; Glycerol; Sodium azide; Sodium heparin; PBS; SC; hamster; 2002; 10 days; controls received mp w/ vehicle solution; telemetry tracked temperature and activity.

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P2312 Hebert,N.J., Kim,J.H., Lin,R.J., Nicoll,C.S. Restoration of lactation in bromocriptine-treated rats by prolactin replacement: comparison of constant versus pulsatile infusion and intrahepatic versus intrajugular routes of delivery. J.Endocrinol.Invest. 1993; 16(--):29-35. >>> Prolactin, ovine; IV (jugular); IV (hepatic portal); rat; 2001; 5 days; controls received mp w/ solvent; functionality of mp verified by in vitro dye testing of pulsatile release; comparison of pulsed delivery w/ mp vs. continuous infusion w/ mp; pulsed delivery; "Constant infusion of oPRL. . . was, overall, more effective at restoring lactation. . . than was giving pulses, regardless of the site of delivery." (pg. 29).

P2003 Liu,Y., Hyde,J.F., Vore,M. Prolactin regulates maternal bile secretory function post partum. J.Pharmacol.Exp.Ther. 1992; 261(-2-):560-566. >>> Prolactin; Glycerol; Sodium azide; Sodium carbonate; IV (jugular); rat; 2001; 6 days; dose-response (table p564).

P1889 Arbogast,L.A., Voogt,J.L. Hyperprolactinemia increases and hypoprolactinemia decreases tyrosine hydroxylase messenger ribonucleic acid levels in the arcuate nuclei, but not the substantia nigra or zona incerta. Endocrinology 1991; 128(-2-):997-1005. >>> Prolactin; Heparin; Sodium bicarbonate; Sodium chloride; IV (jugular); rat; 2001; 7 days; Animal info (SD, F, 175-225 g); 50 U/ml of heparin.

P1844 Youngren,O.M., El Halawani,M.E., Silsby,J.L., Phillips,R.E. Intracranial prolactin perfusion induces incubation behavior in turkey hens. Biol.Reprod. 1991; 44(-3-):425-431. >>> Prolactin, ovine; Ammonium bicarbonate; Saline; CSF/CNS; bird (turkey); 2ML4; 14 days; peptides.

P1834 Pedersen,H.C. Effects of exogenous prolactin on parental behaviour in free-living female willow ptarmigan lagopus l. lagopus. Anim.Behav. 1989; 38(--):926-934. >>> Prolactin; Sodium bicarbonate; SC; bird (ptarmigan); 2001; 6 days; pumps replaced after 6 days; flow calculated for birds' higher body temp. to be 1.15 ul/hr; peptides.

P1832 English,D.E., Russell,S.M., Katz,L.S., Nicoll,C.S. Evidence for a role of the liver in the mammotrophic action of prolactin. Endocrinology 1990; 126(-5-):2252-2256. >>> Prolactin, ovine; Glycerol; Sodium azide; IV (jugular); IV (hepatic portal); rat; 2 weeks; pulse delivery; peptides.

P1758 Hebert,N.J., Kim,J.H., Nicoll,C.S. On the possible role of the liver in the galactopoietic action of prolactin in the rat. Endocrinology 1991; 128(-3-):1505-1510. >>> Prolactin, ovine; Glycerol; heparin, porcine sodium; sodium azide; IV (external jugular); IV (hepatic portal); rat; 2001; no duration posted; Functionality of mp verified by serum RIA; stability verified by incubation in pumps in vitro at 37 degrees celsius for 2 days, data given out to 6 days; 5 doses of prolactin infused; 250 U/ml porcine, sodium heparin used; animal info (Long-Evans, F).

P1589 Madon,R.J., Ensor,D.M., Flint,D.J. Hypoinsulinaemia in the lactating rat is caused by a decreased glycaemic stimulus to the pancreas. J.Endocrinol. 1990; 125(--):81-88. >>> Growth hormone, ovine; Prolactin, ovine; rat; 2001; 5 days; functionality of mp verified by serum levels; replacement therapy (oviarectomy) in some of the prolactin-treated animals.

P1422 Yamazoe,Y., Shimada,M., Murayama,N., Kato,R. Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J.Biol.Chem. 1987; 262(-15-):7423-7428. >>> Growth hormone, human; Prolactin, ovine; SC; rat; 2001; 7 days; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1375 Oscarsson,J., Jansson,J.-O., Eden,S. Plasma pattern of growth hormone regulates sexual differentiation of phosphatidylcholine in rat plasma. Acta Physiol.Scand. 1988; 133(--):257-265. >>> Growth hormone, human; Prolactin, ovine; Saline; SC; rat; 2001; 7 days; controls received sham surgery; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1361 Brelje,T.C., Sorenson,R.L. Nutrient and hormonal regulation of the threshold of glucose-stimulated insulin secretion in isolated rat pancreases. Endocrinology 1988; 123(-3-):1582-1590. >>> Growth hormone, bovine; Prolactin, ovine; Glycerol; Sodium bicarbonate; Water; SC; rat; 2ML1; 4 days; functionality of mp verified by serum levels; peptides.

P1336 Oscarsson,J., Eden,S. Sex differences in fatty acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth hormone. Biochim.Biophys.Acta 1988; 959(--):280-287. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; Glycerol; PBS; Saline; Sodium azide; Water; SC; rat; 2001; 6 days; comparison of sc injections 2x daily vs. mp infusion; replacement therapy (gonadectomy and hypophysectomy); peptides.

P1264 Kishi,K., Ogren,L., Southard,J.M., Talamantes,F. Pituitary factors regulating mouse placental lactogen-II secretion during the last half of pregnancy in mice. Endocrinology 1988; 122(-5-):2309-2317. >>> Growth hormone, murine; Prolactin, murine; Prolactin, bovine; Saline; SC; mice (pregnant); 2001; no duration posted; controls received mp w/saline; dose-response; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1151 Blanck,A., Hansson,T., Eriksson,L.C., Gustafsson,J.-A. Growth hormone modifies the growth rate of enzyme-altered hepatic foci in male rats treated according to the resistant hepatocyte model. Carcinogenesis 1987; 8(-11-):1585-1588. >>> Growth hormone, bovine; Prolactin, ovine; SC; rat; 2001; 2002; 7, 20 days; controls received mp sized tubing; concomitant infusion of agents; 2001 replaced w/ 2002 after 7 days; 2-AAF suppl.; peptides; cancer.

P1146 Sorenson,R.L., Johnson,M.G., Parsons,J.A., Sheridan,J.D. Decreased glucose stimulation threshold, enhanced insulin secretion, and increased beta cell coupling in islets of prolactin-treated rats. Pancreas 1987; 2(-3-):283-288. >>> Prolactin, ovine; Glycerol; Sodium bicarbonate; SC; rat; 2ML1; 4 days; controls received mp w/ vehicle; dose-response (text); functionality of mp verified; peptides.

P1005 Norstedt,G., Husman,B., Mode,A., Eneroth,P., Lewis,U.J., Gustafsson,J.-A. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol. 1987; 114(--):350-356. >>> Prolactin, human; Growth hormone, bovine; Growth hormone, human; Growth hormone, rat; Lactogen, human placental; Prolactin, ovine; Prolactin, rat; 125I tracer; Saline; Sodium bicarbonate; Sodium carbonate; Tris buffer; SC; rat; 2001; 2ML1; 1 week; mp w/vehicle; peptides; replacement therapy (hypophysectomy).

P0981 Nilsson,A., Isgaard,J., Lindahl,A., Peterson,L., Isaksson,O. Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats. Calcif.Tissue Int. 1987; 40(-2-):91-96. >>> Growth hormone, human; Insulin-like growth factor I; Prolactin, ovine; Saline, heparinized; IA (femoral); rat; 2002; 14 days; controls were untreated; mp connected to catheter in femoral artery; replacement therapy (hypophysectomy); local IA infusion; peptides.

P0949 Grosvenor,C.E., Shyr,S.W., Crowley,W.R. Effect of neonatal prolactin deficiency on prepubertal tuberoinfundibular and tuberohypophyseal dopaminergic neuronal activity. Endocrinol.Exp. 1986; 20(-2/3-):223-228. >>> Prolactin, ovine; Saline; SC; rat; 2001; 6 days; controls received mp w/saline; dose-response; peptides.

P0885 Shyr,S.W., Crowley,W.R., Grosvenor,C.E. Effect of neonatal prolactin deficiency on prepubertal tuberinfundibular and tuberohypophyseal dopaminergic neuronal activity. Endocrinology 1986; 119(-3-):1217-1221. >>> Prolactin, ovine; Saline; SC; rat; 2001; 2-5 days; controls received mp w/saline; teratology; pumps implanted on postpartum day 2; half of mp group received bromocriptine treatment also; peptides.

P0808 Joseph,J.A., Lippa,A.S. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration II. non-stereotypic behaviors. Neurobiol.Aging 1986; 7(-1-):37-40. >>> Prolactin, rat; Saline; SC; rat; 2001; 7 days; peptides.

P0807 Joseph,J.A., Roth,G.S., Lippa,A.S. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration I. rotational behavior. Neurobiol.Aging 1986; 7(-1-):31-35. >>> Prolactin, rat; Saline; SC; rat; 2001; 7 days; 6-OHDA lesions in left substantia nigra; peptides.

P0771 Schlechter,N.L., Russell,S.M., Greenberg,S., Spencer,E.M., Nicoll,C.S. A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion. Am.J.Physiol. 1986; 250(--):E231-E235. >>> Growth hormone, rat; Prolactin, ovine; Glycerol; Sodium azide; IA (superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); mp connected to catheter in superior vesicle artery; detailed description and diagram of catheter apparatus; constant and pulsed delivery of GH; peptides.

P0767 Mills,D.E., Ward,R.P. Effect of prolactin on blood pressure and cardiovascular responsiveness in the rat. Proc.Soc.Exp.Biol.Med. 1986; 181(--):3-8. >>> Prolactin, ovine; Saline; IP; rat; 2001; 7 days; dose-response (plasma levels); various doses af agent infused; oPRL half-life; peptides.

P0725 Jellinck,P.H., Quail,J.A., Crowley,C.A. Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes. Endocrinology 1985; 117(--):2274-2278. >>> Growth hormone, human; Prolactin; Saline; SC; rat; 2001; 5-7 days; peptides.

P0710 Mills,D.E., Woods,R.B. Interaction of prolactin with adrenal hormones in blood pressure regulation in rats. Am.J.Physiol. 1985; 249(--):E614-E618. >>> Corticosterone; Epinephrine; Norepinephrine; Prolactin, ovine; Ethanol; Sodium chloride; Water; IP; rat; 2001; 7 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents; multiple pumps per animal (2) for CORT; hypertension; controls received mp w/NaCl; peptides.

P0688 MacGeoch,C., Morgan,E.T., Gustafsson,J.-A. Hypothalamo-pituitary regulation of cytochrome P-450(15B) apoprotein levels in rat liver. Endocrinology 1985; 117(-5-):2085-2092. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; SC; rat; 2001; 2ML1; 1 week; comparison of twice daily sc injec of rat GH vs. mp infusion; replacement therapy (hyposphysectomy); controls received sham mp made of silicone; tubing; peptides.

P0667 Dembinski,T.C., Leung,C.K.H., Shiu,R.P.C. Evidence for a novel pituitary factor that potentiates the mitogenic effect of estrogen in human breast cancer cells. Cancer Res. 1985; 45(-7-):3083-3089. >>> Growth hormone, human; Growth hormone, ovine; Prolactin, ovine; mice; 49-56 days; comparison of daily sc injec. vs. mp infusion; comparison of agents effects; long-term study; cancer; peptides.

P0639 Mick,C.C.W., Nicoll,C.S. Prolactin directly stimulates the liver in vivo to secrete a factor (synlactin) which acts synergistically with the hormone. Endocrinology 1985; 116(-5-):2049-2053. >>> Growth hormone, ovine; Prolactin, ovine; Citric acid; Glycerol; IV (hepatic portal); IV (jugular); bird (pigeon); 2001; 1 week; comparison of agents effects; citric acid added to solvent for bacteriostatic effects; pulsed delivery of hormone or solvent (intermittent w/ air); peptides; tissue perfusion.

P0573 Morgan,D.G., Mobbs,C.V., Anderson,C.P., Sinha,Y.N., Finch,C.E. Hyperprolactinemia fails to increase striatal dopamine receptors in male and female C57BL/6J mice. Eur.J.Pharmacol. 1984; 107(-1-):101-104. >>> Prolactin, ovine; Saline; SC; mice; 2001; 1 week; comparison of homotypic anterior pituitary grafts vs. mp prolactin infusion; dose-response data; peptides.

P0535 Baxter,R.C., Zaltsman,Z. Induction of hepatic receptors for growth hormone (GH) and prolactin by GH infusion is sex independent. Endocrinology 1984; 115(-5-):2009-2014. >>> Growth hormone, rat; Prolactin, rat; SC; rat; 1 week; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0460 Haaparanta,T., Glaumann,H., Gustafsson,J.-A. Characterization and endocrine regulation of the cytochrome P-450 dependent microsomal hydroxylation of 5a-androstane-3B,17B-diol in the rat ventral prostate. Endocrinology 1984; 114(-6-):2293-2300. >>> Growth hormone, human; Prolactin, ovine; Sodium hydroxide; Saline; SC; rat; 2001; 1 week; vehicle used w/PRL was saline&NaOH; saline used alone as vehicle w/hGH; peptides.

P0450 Baxter,R.C., Zaltsman,Z., Turtle,J.R. Rat growth hormone (GH) but not prolactin (PRL) induces both GH and PRL receptors in female rat liver. Endocrinology 1984; 114(-5-):1893-1901. >>> Growth hormone, ovine; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; comparison of agents effects; peptides.

P0330 Hruska,R.E., Pitman,K.T., Silbergeld,E.K., Ludmer,L.M. Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats. Life Sci. 1982; 30(--):547-553. >>> Prolactin, ovine; Saline; SC; rat; 7-8 days; comparison of injec vs. mp infusion; peptides.

P0329 Levin,P., Haji,M., Joseph,J.A., Roth,G.S. Effect of aging on prolactin regulation of rat striatal dopamine receptor concentrations. Life Sci. 1983; 32(--):1743-1749. >>> Prolactin, rat; Saline; SC; rat; 2001; 1 week; peptides.

P0322 Ewing,L.L., Wing,T.-Y., Cochran,R.C., Kromann,N., Zirkin,B.R. Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 1983; 112(-5-):1763-1769. >>> Follicle stimulating hormone; Growth hormone, ovine; Luteinizing hormone; Prolactin, ovine; Thyroid-stimulating hormone; Borate; Peanut oil; SC; rat; 5 days; replacement therapy (hypophysectomy); simultaneous infusion of testosterone&estradiol implants w/ mp infusion of polypeptides; pulsed delivery of agents (intermittent w/ vehicle); peptides; ovine LH used.

P0318 Herbert,J., Martensz,N.D. The effects of intraventricular prolactin infusions on pituitary responsiveness to thyrotropin-releasing hormone, 5-hydroxytryptophan or morphine in rhesus monkeys. Brain Research 1983; 258(--):251-262. >>> Prolactin, ovine; Albumin, bovine serum; CSF/CNS; monkey; 2ML1; 6 days; comparison of injec. vs mp infusion; peptides.

P0230 Skett,P., Young,C. The effects of pituitary hormones on hepatic drug metabolism in the rat. Acta Endocrinol. 1982; 100(--):421-426. >>> Follitropin, rat; Thyrotropin, rat; Growth hormone, human; Growth hormone, rat; Pituitary extract; Prolactin, rat; Saline; Water; SC; rat; 1701; 6 days; organ replacement therapy (hypophysectomy); agents also injected - comparison of injec vs. mp infusion; peptides.

P0215 Norstedt,G. A comparison between the effects of growth hormone on prolactin receptors and estrogen receptors in rat liver. Endocrinology 1982; 110(-6-):2107-2112. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; organ replacement therapy (hypophysectomy); intermittent injections vs. infusion; peptides.

P0212 Pousette,A., Bjork,P., Carlstrom,K., Forsgren,B., Hogberg,B., Gustafsson,J.-A. Influence of pituitary and adrenocortical hormones on prostatic secretion protein, a major protein in rat prostate. The Prostate 1982; 3(--):109-114. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 2 weeks; replacement therapy (hypophysectomy); peptides.

P0168 Mills,D.E., Buckman,M.T., Peake,G.T. Effects of prolactin administration and suppression on blood pressure and body fluid compartments in the rat. Endocrinology 1981; 109(-5-):1590-1596. >>> Lergotrile mesylate; Prolactin, ovine; Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat; no duration posted; Exp. 1-3, 1701, 7 days: 1)saline, oPRL,&LM&oPRL simultaneously; 2&3)saline, oPRL, Vasopressin, 1-desamino-8-D arginine; 4) 2001, 7 days, saline, oPRL; peptides.

P0155 Shafie,S.M., Grantham,F.H  J.Natl.Cancer Inst. 1981; 67(-1-):51-56. >>> Prolactin, ovine; Saline; IP; mice (nude); no duration posted; replacement therapy (hypophysectomy); cancer; peptides.

P0148 Gustafsson,J.-A., Eneroth,P., Hokfelt,T., Mode,A., Norstedt,G., Skett,P. Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents. Environ.Health Perspect. 1981; 38(--):129-141. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; SC; rat; 7 days; replacement therapy (hypophysectomy); toxicology; peptides.

P0133 Mode,A., Norstedt,G., Simic,B., Eneroth,P., Gustafsson,J.-A. Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 1981; 108(-6-):2103-2108. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0126 Norstedt,G., Mode,A., Eneroth,P., Gustafsson,J.-A. Induction of prolactin receptors in rat liver after the administration of growth hormone. Endocrinology 1981; 108(-5-):1855-1861. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0118 Norstedt,G., Wrange,O., Gustafsson,J.-A. Multihormonal regulation of the estrogen receptor in rat liver. Endocrinology 1981; 108(-4-):1190-1196. >>> Growth hormone, bovine; Prolactin, bovine; Prolactin, ovine; Sodium hydroxide; Saline; SC; rat; 7 days; comparison of agents; organ replacement therapy (hypophysectomy); separate infusion of all hormones&simultaneous infusion of oPRL&bGH (2 pumps/animal); peptides.

P0071 Murphy,B.D., Humphrey,W.D., Shepstone,S.L. Luteal function in mink: the effects of hypophysectomy after the preimplantation rise in progesterone. Anim.Reprod.Sci. 1980; 3(--):225-232. >>> Luteinizing hormone; Prolactin, bovine; Saline; IP; mink; 7 days; organ replacement therapy (hypophysectomy); peptides; ovine LH used.