References on the Administration of Prolactin Using ALZET® Osmotic Pumps

15774 Colin M. Hyslop,, Sue Tsai,, Vipul Shrivastava,, Pere Santamaria,, Carol Huang  Endocrinology 2016; 157(-1-):150-165. >>> Prolactin, recombinant mouse; Albumin, mouse; Mice (NOD); 1004; Controls received mp w/ vehicle; Controls received mp w/ vehicle; diabetes; Therapeutic indication (diabetes); Dose (2.7 ug/d); resulted in serum PRL level 300-500 ng/mL;.

15157 Yonezawa, T., Chen, K.H., Ghosh, M.K., Rivera, L., Dill, R., Ma, L.S., Villa, P.A., Kawaminami, M., Walker, A.M., Walker, A.M. Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer. CANCER LETTERS 2015; 366(--):84-92. >>> Prolactin, recombinant human; oligomer, splice-modulating; SC; Mice (NOD/SCID); Controls received mp w/ vehicle; animal info (female, BALB/cJ or NOD SCID, 8-9 weeks old); functionality of mp verified by plasma levels; pumps replaced every 28 days; cancer (breast); dose-response (pg 87);.

14998 Kondegowda, N.G., Fenutria, R., Pollack, I.R., Orthofer, M., Garcia-Ocana, A., Penninger, J.M., Vasavada, R.C., Vasavada, R.C. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-kappaB Ligand Pathway. Cell Metabolism 2015; 22(--):77-85. >>> Prolactin, ovine; PBS; BSA; SC; Mice; Controls received mp w/ saline; animal info (male, OPG-KO, 12-14 weeks old); diabetes;.

14898 Crawford, H.M., Morin, D.E., Wall, E.H., McFadden, T.B., Dahl, G.E., Dahl, G.E. Evidence for a Role of Prolactin in Mediating Effects of Photoperiod during the Dry Period. ANIMALS 2015; 5(--):803-820. >>> Prolactin; Saline; SC; Cattle (pregnant); Controls received no mp; animal info (female, Holstein, multiparous); functionality of mp verified by blood samples; pumps removed after 28 days;.

14365 Ricke-Hoch, M., Bultmann, I., Stapel, B., Condorelli, G., Rinas, U., Sliwa, K., Scherr, M., Hilfiker-Kleiner, D., Hilfiker-Kleiner, D. Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress. Cardiovascular Research 2014; 101(--):587-596. >>> Prolactin; Saline; Mice (pregnant); Controls received mp w/ vehicle; animal info (female, CKO, pregnant); cardiovascular; peptides;.

13724 Buntin, J.D., Buntin, L., Buntin, J.D. Increased STAT5 signaling in the ring dove brain in response to prolactin administration and spontaneous elevations in prolactin during the breeding cycle. General and Comparative Endocrinology 2014; 200(--):1-9. >>> Prolactin, ovine; Saline; sodium bicarbonate; SC; Bird (ring dove); 2001; Controls received mp w/ vehicle; animal info (female, ring doves, adult, non-breeding);.

13424 Yang, D.B., Li, L., Wang, L.P., Chi, Q.S., Hambly, C., Wang, D.H., Speakman, J.R. Limits to sustained energy intake. XIX. A test of the heat dissipation limitation hypothesis in Mongolian gerbils (Meriones unguiculatus). Journal of Experimental Biology 2013; 216(-17-):3358-3368. >>> Prolactin; Saline; SC; Gerbil; 2002; Controls received mp w/ vehicle; animal info (female, Mongolian,6-7 months old, 59-88g); functionality of mp verified by serum levels; behavioral testing (physical activity);.

13345 Adan, N., Guzman-Morales, J., Ledesma-Colunga, M.G., Perales-Canales, S.I., Quintanar-Stephano, A., Lopez-Barrera, F., Mendez, I., Moreno-Carranza, B., Triebel, J., Binart, N., de la Escalera, G.M., Thebault, S., Clapp, C. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. Journal of Clinical Investigation 2013; 123(-9-):3902-3913. >>> Prolactin, ovine; SC; Rat; Animal info (male, Sprague Dawley, 200-250g); functionality of mp verified by serum levels at 21 days; behavioral testing (hind paw pain); immunology;.

12755 Wang, W.B., Pan, Y.W., Wietecha, T., Zou, J.H., Abel, G.M., Kuo, C.T., Xia, Z.G. Extracellular Signal-regulated Kinase 5 (ERK5) Mediates Prolactin-stimulated Adult Neurogenesis in the Subventricular Zone and Olfactory Bulb. Journal of Biological Chemistry 2013; 288(-4-):2623-2631. >>> Prolactin, mouse, recomb.; Albumin, mouse serum; saline; SC; Mice; 1007D; Control animals received mp w/ vehicle; animal info (male, female, Nestin CreER TM/ERK5 loxP/loxP, 8-10 wks old).

12735 Walker, T.L., Vukovic, J., Koudijs, M.M., Blackmore, D.G., Mackay, E.W., Sykes, A.M., Overall, R.W., Hamlin, A.S., Bartlett, P.F. Prolactin Stimulates Precursor Cells in the Adult Mouse Hippocampus. PLoS One 2012; 7(-9-):U456-U466. >>> Prolactin, mouse, recomb; BSA; saline, sterile; CSF/CNS (hippocampus); Mice; 1007D; Control animals received mp w/ vehicle; animal info (C57BL/6, adult); behavioral testing (Morris water maze test, Porsolt forced swim test, open field test, Y maze test).

12655 Sonigo, C., Bouilly, J., Carre, N., Tolle, V., Caraty, A., Tello, J., Simony-Conesa, F.J., Millar, R., Young, J., Binart, N. Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration. Journal of Clinical Investigation 2012; 122(-10-):3791-3795. >>> Prolactin; SC; Mice; 2004; Control animals received mp w/ PBS; animal info (6 wks old, adult, female).

12476 Park, S., Kang, S., Lee, H.W., Ko, B.S. Central Prolactin Modulates Insulin Sensitivity and Insulin Secretion in Diabetic Rats. Neuroendocrinology 2012; 95(-4-):332-343. >>> Prolactin, rat; NaHCO3; NaCl; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 224 g).

11215 Mak, G.K., Weiss, S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nature Neuroscience 2010; 13(-6-):753-U134. >>> Prolactin, mouse, recomb.; luteinizing hormone, mouse, recomb.; antibody, prolactin neutralizing; Albumin, mouse, serum; PBS;; SC; CSF/CNS; Mice; 1003D; 1007D; Controls received mp w/ vehicle or normal goat antibody; animal info (8 wks old, Prlr +/+, Prlr -/-, male).

10764 Ziegler, T.E., Prudom, S.L., Zahed, S.R., Parlow, A.F., Wegner, F. Prolactin's mediative role in male parenting in parentally experienced marmosets (Callithrix jacchus). Hormones and Behavior 2009; 56(-4-):436-443. >>> Prolactin, human, recomb.; Glycerol; NaHCO3; NaCl; SC; Monkey (marmoset); 2004; Controls received mp w/ saline; animal info (2.5-9 yrs old, male, parentally experienced);"... these pellets (from Innovative Research of America) did not raise the level of prolactin in the blood over the level of our control parentally experienced fathers... Therefore, we chose to use the osmotic minipump (Alzet, CA) for our test males."pg 439;"The position of the pumps on the lower area of a male's back precluded any interference with infant carrying since infant carrying occurs nearer the neck"pg 439; comparison of pellets vs mp.

9070 Augustine, R.A., Grattan, D.R. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology 2008; 149(-3-):1049-1055. >>> Prolactin, ovine; CSF, artificial; CSF/CNS; Rat; 2001; Controls received mp w/ vehicle; peptides; animal info (female, Sprague Dawley, 10 wks old, 200-300g., pseudopregnant); endocrinology.

9040 Naef, L., Woodside, B. Prolactin/Leptin interactions in the control of food intake in rats. Endocrinology 2007; 148(-12-):5977-5983. >>> Prolactin, ovine; NaHCO3; HCl; CSF/CNS; Rat; 2001; 2002; Controls received mp w/ vehicle; dose-response (Fig. 1); peptides; animal info (female, Wistar, 220-240g.).

8910 Grattan, D.R., Jasoni, C.L., Liu, X.H., Anderson, G.M., Herbison, A.E. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology 2007; 148(-9-):4344-4351. >>> Prolactin, ovine; CSF/CNS; Mice; 1002; Serum levels taken, peptides, animal info (adult, female, C57BL6/J, 6-8 weeks, 24-28g, OVX).

8704 Williams, V.L., DeGuzman, A., Dang, H., Kawaminami, M., Ho, T.W.C., Carter, D.G., Walker, A.M. Common and specific effects of the two major forms of prolactin in the rat testis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 293(-6-):E1795-E1803. >>> Prolactin; Saline; SC; Rat; Controls received mp w/ vehicle; plasma levels taken; peptides; animal info (male).

8651 Gregg, C., Shikar, V., Larsen, P., Mak, G., Chojnacki, A., Yong, V.W., Weiss, S. White matter plasticity and enhanced remyelination in the maternal CNS. Journal of Neuroscience 2007; 27(-8-):1812-1823. >>> Prolactin, recomb. mouse; Saline; albumin mouse serum; SC; Mice; 1007D; Controls received mp w/ vehicle; peptides; animal info (female, CD-1, 6-8 wks old).

8453 Craven, A.J., Nixon, A.J., Ashby, M.G., Ormandy, C.J., Blazek, K., Wilkins, R.J., Pearson, A.J. Prolactin delays hair regrowth in mice. Journal of Endocrinology 2006; 191(-2-):415-425. >>> Prolactin, ovine; domperidone; Sodium bicarbonate buffer; PEG 400; SC; Mice; 1003D; 1007D; 1002; Controls received no treatment; functionality of mp verified by plasma prolactin levels; animal info (Balb/c, 18-30 days old).

8229 Hilfiker-Kleiner, D., Kaminski, K., Podewski, E., Bonda, T., Schaefer, A., Sliwa, K., Forster, O., Quint, A., Landmesser, U., Doerries, C., Luchtefeld, M., Poli, V., Schneider, M.D., Balligand, J.L., Desjardins, F., Ansari, A., Struman, I., Nguyen, N.Q.N., Zschemisch, N.H., Klein, G., Heusch, G., Schulz, R., Hilfiker, A., Drexler, H. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 2007; 128(-3-):589-600. >>> Prolactin, recomb; Mice; Controls received mp w/ saline; cardiovascular; peptides; animal info (female).

7911 Combs, T.P., Berg, A.H., Rajala, M.W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J.C., Patti, M.E., Klein, S.L., Weinstein, R.S., Scherer, P.E. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003; 52(-2-):268-276. >>> Prolactin; bromocriptine; SC; Mice; 1007D; Animal info (female, C57BL/6J).

7915 Guzman, E.A., Chen, Y.H., Langowski, J.L., De Guzman, A., Lo, H.L., Walter, B., Muller, H.K., Walker, A.M., Owen, L.B. Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. Journal of Neuroimmunology 2005; 170(-1-2-):31-40. >>> Prolactin, recomb.; prolactin, S179D; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; immunology; animal info (male, C3H/HeJ or C3H/HeJ-TnFsF6gld, 10-12 wk. old).

7834 Obal, F.Jr, Garcia-Garcia, F., Kacsoh, B., Taishi, P., Bohnet, S., Horseman, N.D., Krueger, J.M. Rapid eye movement sleep is reduced in prolactin-deficient mice. Journal of Neuroscience 2005; 25(-44-):10282-10289. >>> Prolactin, murine; Saline, physiological; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (C57BL/6J, pRL, KO, male, 25-30 g, 8-16 wk old).

7660 Leonard, S.T., izadeh-Naderi, R., Stokes, K., Ferkin, M.H. The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. PHYSIOLOGY&BEHAVIOR 2005; 85(-4-):461-468. >>> Bromocriptine; prolactin, ovine; Saline, sterile; SC; Prairie vole; 2004; Controls received mp w/ vehicle; replacement therapy (gonadectomy); animal info (male, meadow); animals also received testosterone via silastic implant at same time.

7409 Nasir, I., Kedees, M.H., Ehrlich, M.E., Teitelman, G. The role of pregnancy hormones in the regulation of Pdx-1 expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2005; 233(-1-2-):1-13. >>> Prolactin, bovine; NaHCO3; SC; Mice; 2001; Controls received mp w/ vehicle; functionality of mp verified by serum bPRL levels; peptides; multiple pumps per animal (2).

7253 Auchtung, T.L., Dahl, G.E. Prolactin mediates photoperiodic immune enhancement: Effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers. Biology of Reproduction 2004; 71(-6-):1913-1918. >>> Prolactin, recomb. bovine; Saline; SC; Cattle; 2ML2; Comparison of IV injections vs mp; no stress ( see pg. 1914); immunology; peptides; post op. care (prodine, excenel); each animal received 4 rounds of 10 day prolactin treatment (2 w/ mp, 2 IV injection) with 11 days of non treatment between each round; wound clips used.

6872 Xu, X.L., Wu, W., Williams, V., Khong, A., Chen, Y.H., Deng, C.H., Walker, A.M. Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate. PROSTATE 2003; 54(-1-):25-33. >>> Prolactin, human recomb.; prolactin, S179D; Saline; SC; Rat; 2004; Comparison of SC injections vs. mp; peptides.

6491 Payne, A.P., Shah, S.W., Marr, F.A., McGadey, J., Thompson, G.G., Moore, M.R. Hormones and the Control of Porphyrin Biosynthesis and Structure in the Hamster Harderian Gland. Microscopy Res. and Tech 1996; 34(--):123-132. >>> Bromocriptine; prolactin; Hamster; Replacement therpay (castration, ovariectomy); multiple pumps per animal (2).

5968 Hedlund, G.P., Carlsson, H.E., Shieck, E., Nilsson, I., Lundblad, C., Arons, S., Iversen, A.K., Looman, C., Jensen, H.E., Hau, J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Growth hormone, human; prolactin, ovine; growth hormone, bovine; Saline; SC; Rat; 2ML1; Controls received mp w/ PBS vehicle; peptides; agents infused separately or concomitantly.

5836 Johnson, T.E., Vue, M., Brekhus, S., Khong, A., Ho, T.W.C., Walker, A.M. Unmodified prolactin (PRL) promotes PRL secretion and acidophil hypertrophy and is associated with pituitary hyperplasia in female rats. Endocrine 2003; 20(-1-2-):101-109. >>> Prolactin; Saline; SC; Rat (pregnant); 2001; 2004; peptides; unmodified (u-PRL)&phosphorylated (p-PRL) prolactin used.

5835 Nahi, F., Arbogast, L.A. Prolactin modulates hypothalamic preproenkephalin, but not proopiomelanocortin, gene expression during lactation. Endocrine 2003; 20(-1-2-):115-122. >>> Prolactin, ovine; Sodium bicarbonate; heparin; NaCl; IV (jugular); Rat; Controls received mp w/ vehicle; half-life = 6 hours (p.119); peptides; heparin dose 50 U/ml.

5594 Kuo, C.B., Wu, W., Xu, X.L., Yang, L.L., Chen, C., Coss, D., Birdsall, B., Nasseri, D., Walker, A.M. Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell and Tissue Research 2002; 309(-3-):429-437. >>> Prolactin, S179D; Saline; SC; Rat; 2001; 2004; .

5541 Yang, L., Lii, S., Kuo, B., Buckley, A., Buckley, D., Chen, C., Xu, X.L., Coss, D., Walker, A.M. Maternal prolactin composition can permanently affect epidermal gamma delta T cell function in the offspring. Developmental and Comparative Immunology 2002; 26(-9-):849-860. >>> Prolactin, recomb; prolactin, phosphorylated; Saline; Rat (pregnant); 2002; Controls received mp w/ vehicle; teratology; peptides; apoptosis.

5367 Sockman, K.W., Schwabl, H., Sharp, P.J. The role of prolactin in the regulation of clutch size and onset of incubation behavior in the American kestrel. Horm. Behav 2000; 38(-3-):168-176. >>> Prolactin, ovine; NaCO3; NaCl; SC; Bird (kestrel); 1002; Controls received mp w/ vehicle; prolactin plasma levels checked; dose-response (p.173); 17 min. half-life (p.171).

5272 Torner, L., Toschi, N., Nava, G., Clapp, C., Neumann, I.D. Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses. European Journal of Neuroscience 2002; 15(--):1381-1389. >>> Oligodeoxynucleotide, antisense; Prolactin, ovine; Ringer's solution; CSF/CNS; Rat (lactating); 1007D; controls received mp w/ vehicle; antisense; oligonucleotides against the long form of the brain Prolactin receptor.

5066 Torner, L., Toschi, N., Pohlinger, A., Landgraf, R., Neumann, I.D. Anxiolytic and anti-stress effects of brain prolactin: Improved efficacy of antisense targeting of the prolactin receptor by molecular modeling. Journal of Neuroscience 2001; 21(-9-):3207-3214. >>> Oligonucleotide, antisense; Prolactin, ovine; Ringer's solution; CSF/CNS; rat; 1007D; controls received mp w/ vehicle; comparison of ICV injections vs. mp; peptides; antisense; antisense ODN was anti-prolactin..

4980 Xu, X.L., Kreye, E., Kuo, C.B., Walker, A.M. A molecular mimic of phosphorylated prolactin markedly reduced tumor incidence and size when DU145 human prostate cancer cells were grown in nude mice. Cancer Research 2001; 61(--):6098-6104. >>> Prolactin; S179D; SC; Mice (nude); 2004; controls received mp w/ vehicle; functionality of mp verified by plasma prolactin levels; peptides; cancer (prostate); S179D is a prolactin receptor antagonist; wild-type prolactin used..


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“A continuous infusion paradigm was utilized in both experiments to minimize any potential hemodynamic side effects from bolus NTG administration... Cha et al., Pharm Bioch and Behav 2003;74:551-557.