References on the Administration of Parathyroid Hormone Using ALZET^® Osmotic Pumps

Q0709 Kurio,N., Shimo,T., Fukazawa,T., Takaoka,M., Okui,T., Hassan,N.M.M., Honami,T., Hatakeyama,S., Ikeda,M., Naomoto,Y., Sasaki,A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAX and IGF-IR in vitro and in vivo. Experimental Cell Research 2011; 317(-8-):1134-1146. >>> Parathyroid hormone-related peptide (1-34); Saline, physiological; cysteine, L-; SC; Mice (nude); 1007D; ; Controls received mp w/ vehicle; animal info (5 wls old, male, BALB/c); cancer.

Q0002 Batista,D.G., Neves,K.R., Graciolli,F.G., dos Reis,L.M., Graciolli,R.G., Dominguez,W.V., Neves,C.L., Magalhaes,A.O., Custodio,M.R., Moyses,R.M., Jorgetti,V. The Bone Histology Spectrum in Experimental Renal Failure: Adverse Effects of Phosphate and Parathyroid Hormone Disturbances. Calcified Tissue International 2010; 87(-1-):60-67. >>> Parathyroid hormone, recomb. rat (1-34); Cysteine; SC; Rat; 2ML4; 56 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 280-330 g); functionality of mp verified by hormone serum levels; replacement therapy (parathyroidectomy, nephrecotomy (5/6)); pumps replaced after 28 days; long-term study.

Q0003 Berbel,P., Navarro,D., Auso,E., Varea,E., Rodriguez,A.E., Ballesta,J.J., Salinas,M., Flores,E., Faura,C.C., De Escobar,G.M. Role of Late Maternal Thyroid Hormones in Cerebral Cortex Development: An Experimental Model for Human Prematurity. Cerebral Cortex 2010; 20(-6-):1462-1475. >>> Parathyroid hormone, rat (1-84); calcitonin, rat; thyroxine; Acetate buffer; SC; Rat (pregnant); 2001; 4-8 days; Teratology; peptides; animal info (Female, Wistar, 250-300 g); replacement therapy (parathyroidectomy).

Q0877 Etoh,M., Yamaguchi,A. Repetition of continuous PTH treatments followed by periodic withdrawals exerts anabolic effects on rat bone. JOURNAL OF BONE AND MINERAL METABOLISM 2010; 28(-6-):641-649. >>> Parathyroid hormone; SC; Rat; 1007D; 1003D; 4 weeks; 7 days; 24 hours; Controls received mp w/ vehicle; animal info (9 wks old, Sprague-Dawley, female); pumps replaced every 1 week; comparison of once a week and 3-times a week injections vs sc mp; "Continuous PTH treatment as well as intermittent PTH treatment stimulates bone formation, but the former treatment enhances osteoclastic bone resorption that exceeds the stimulated bone formation." pg 647.

Q0324 Lavi-Moshayoff,V., Wasserman,G., Meir,T., Silver,J., Naveh-Many,T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. American Journal of Physiology-Renal Physiology 2010; 299(-4-):F882-F889. >>> Parathyroid hormone (1-34), rat; Cysteine, L-; SC; Mice; 2002; 3 days; Controls received mp w/ vehicle; animal info (C57BL/J6, male, 5-6 wks old).

Q0079 Morte,B., Diez,D., Auso,E., Belinchon,M.M., Gil-Ibanez,P., Grijota-Martinez,C., Navarro,D., De Escobar,G.M., Berbel,P., Bernal,J. Thyroid Hormone Regulation of Gene Expression in the Developing Rat Fetal Cerebral Cortex: Prominent Role of the Ca2+/Calmodulin-Dependent Protein Kinase IV Pathway. Endocrinology 2010; 151(-2-):810-820. >>> Parathyroid hormone (1-84); calcitonin, rat; Acetate buffer; SC; Rat; 2001; ; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-300 g); replacement therapy (parathyroidectomy).

Q0349 Tawfeek,H., Bedi,B., Li,J.Y., Adams,J., Kobayashi,T., Weitzmann,M.N., Kronenberg,H.M., Pacifici,R. Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss. PLoS One 2010; 5(-8-):U56-U69. >>> Parathyroid hormone (1-34), human; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (male, female, 16 wks old, C57BL/6 WT , TNF -/-).

P9492 Galli,C., Fu,Q., Wang,W.F., Olsen,B.R., Manolagas,S.C., Jilka,R.L., O'Brien,C.A. Commitment to the Osteoblast Lineage Is Not Required for RANKL Gene Expression. Journal of Biological Chemistry 2009; 284(-19-):12654-12662. >>> Parathyroid hormone (1-84), human; NaCl; acetic acid; BSA; SC; Mice; 1003D; 24 hours; Controls received mp w/ vehicle; animal info (female, Swiss Webster).

P9662 Graciolli,F.G., Neves,K.R., dos Reis,L.M., Graciolli,R.G., Noronha,I.L., Moyses,R.M.A., Jorgetti,V. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. NEPHROLOGY DIALYSIS TRANSPLANTATION 2009; 24(-5-):1416-1421. >>> Parathyroid hormone (1-34); Cysteine; SC; Rat; 2ML4; 56 days; Controls received mp w/vehicle; replacement therapy (parathyroidectomy); pumps replaced after 28 days; animal info (male, Wistar, 300-330g).

P9945 Kantham,L., Quinn,S.J., Egbuna,O.I., Baxi,K., Butters,R., Pang,J.L., Pollak,M.R., Goltzman,D., Brown,E.M. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2009; 297(-4-):E915-E923. >>> Parathyroid hormone (1-34); human; PBS; acetic acid; cysteine; SC; Mice; 1002; 14 days; Post op.care (analgesia).

P9321 Chang,E.J., Ha,J., Oerlemans,F., Lee,Y.J., Lee,S.W., Ryu,J., Kim,H.J., Lee,Y., Kim,H.M., Choi,J.Y., Kim,J.Y., Shin,C.S., Pak,Y.K., Tanaka,S., Wieringa,B., Lee,Z.H., Kim,H.H. Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption. Nature Medicine 2008; 14(-9-):966-972. >>> Parathyroid hormone (1-34) human; PBS; SC; Mice; 5 days; Controls received mp w/ vehicle; peptides; animal info (Ckb -/-, wt, 8 wks old).

P9111 Gao,Y., Wu,X., Terauchi,M., Li,J.Y., Grassi,F., Galley,S., Yang,X., Weitzmann,M.N., Pacifici,R. T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metabolism 2008; 8(-2-):132-145. >>> Parathyroid hormone (1-34), human; Mice (nude); 1002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (female, C57BL/6, 10 wks old, wt, nu/nu).

P9160 Lowry,M.B., Lotinun,S., Leontovich,A.A., Zhang,M.Z., Maran,A., Shogren,K.L., Palama,B.K., Marley,K., Iwaniec,U.T., Turner,R.T. Osteitis Fibrosa Is Mediated by Platelet-Derived Growth Factor-A Via a Phosphoinositide 3-Kinase-Dependent Signaling Pathway in a Rat Model for Chronic Hyperparathyroidism. Endocrinology 2008; 149(-11-):5735-5746. >>> Parathyroid hormone (1-34), human; SC; Rat; 1, 3, 5, 7, 14, 28 days; Controls received mp w/ vehicle; peptides; animal info (mature, female, Sprague Dawley, 3 or 6 months old).

P9693 Samadfam,R., Xia,Q.W., Miao,D.S., Hendy,G.N., Goltzman,D. Exogenous PTH and endogenous 1,25-dihydroxyvitamin D are complementary in inducing an anabolic effect on bone. Journal of Bone and Mineral Research 2008; 23(-8-):1257-1266. >>> Parathyroid hormone (1-34), recomb. human; SC; Mice; 1, 2, 4, 6, 20 days; Pumps replaced after 10 days; peptides; animal info (3 months old, male C57BL/6).

P8779 Yuan,B., Takaiwa,M., Clemens,T.L., Feng,J.Q., Kumar,R., Rowe,P.S., Xie,Y.X., Drezner,M.K. Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. Journal of Clinical Investigation 2008; 118(-2-):722-734. >>> Parathyroid hormone; Mice; 1003D; 24 hours; Animal info (C57BL/6J, wt, Hyp, Cre-Phex-d-flox/y, OC-Cre-Phex-d-flox/y).

P8578 Fuentes,J, Guerreiro,P.M, Modesto,T  Am J Physiol Regul Integr Comp Physiol 2007; 293(--):R956-R960. >>> Parathyroid hormone-related protein (7-34); IP; Fish (sea bream); ; Controls received mp w/ vehicle; peptides; animal info (Sparus auratus, juvenile).

P9883 Li,X., Liu,H., Qin,L., Tamasi,J., Bergenstock,M., Shapses,S., Feyen,J.H.M., Notterman,D.A., Partridge,N.C. Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. Journal of Biological Chemistry 2007; 282(-45-):33086-33097. >>> Parathyroid hormone (1-34); parathyroid hormone (3-34); parathyroid hormone (1-31); Saline; SC; Rat; 2001; 6, 14 days; Functionality of mp verified by hPTH (1-34) levels; peptides; animal info (female, Sprague Dawley, 3 months old, 250 g.).

P8740 Li,X., Qin,L., Bergenstock,M., Bevelock,L.M., Novack,D.V., Partridge,N.C. Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts. Journal of Biological Chemistry 2007; 282(-45-):33098-33106. >>> Parathyroid hormone, human 1-34; Saline, physiological; SC; Rat; 2001; 3, 6, 14 days; 6 hours; Controls received mp w/ vehicle; comparison SC injections vs. mp; peptides; animal info (female, Sprague-Dawley, 3 months old, 250 g).

P8650 Usatii,M., Rousseau,L., Demers,C., Petit,J.L., Brossard,J.H., Gascon-Barre,M., Lavigne,J.R., Zahradnik,R.J., Nemeth,E.F., D'Amour,P. Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis. Kidney International 2007; 72(-11-):1330-1335. >>> Parathyroid hormone, human 1-34; parathyroid hormone, human 1-84; parathyroid hormone, rat 1-34; parathyroid hormone, rat 1-84; parathyroid hormone, rat 7-84; parathyroid hormone, rat 39-84; Saline; cysteine HCl, L-; IV (jugular); Rat; 1003D; 48 hours; Controls received mp w/ vehicle; replacement therapy (parathyroidectomy); peptides; animal info (male, Sprague-Dawley, 125-150g).

P7986 Wang,W., Praetorius,J., Li,C., Praetorius,H.A., Kwon,T.H., Frokiaer,J., Nielsen,S. Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis. ACTA PHYSIOLOGICA 2007; 189(-4-):359-368. >>> Parathyroid hormone, human; SC; Rat; 1003D; 48 hours; Controls received mp w/ vehicle; animal info (male, Munich-Wistar, 230-260 grams).

P9008 Asaba,Y., Hiramatsu,K., Matsui,Y., Harada,A., Nimura,Y., Katagiri,N., Kobayashi,T., Takewaka,T., Ito,M., Niida,S., Ikeda,K. Urinary gamma-glutamyltransferase (GGT) as a potential marker of bone resorption. Bone 2006; 39(-6-):1276-1282. >>> Parathyroid hormone (1-34), human; Cysteine, L-; SC; Mice; 4 days; Controls received mp w/ vehicle; peptides; animal info (female, BALB/cA, 8 wks old).

P8239 Bounoutas,G.S., Tawfeek,H., Froehlich,L.F., Chung,U.I., bou-Samra,A.B. Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 2006; 147(-10-):4674-4679. >>> Parathyroid hormone, rat 1-34; Acetic acid; serum, mouse, heat-inactivated; SC; Mice; 1003D; 3 days; Controls received mp w/ vehicle; dose-response (table 3); peptides; animal info (male, 12 weeks old, C57BL/J6).

P8974 Mizuta,H., Kudo,S., Nakamura,E., Takagi,K., Hiraki,Y. Expression of the PTH/PTHrP receptor in chondrogenic cells during the repair of full-thickness defects of articular cartilage. OSTEOARTHRITIS AND CARTILAGE 2006; 14(-9-):944-952. >>> Parathyroid hormone (1-84), recomb. human; Saline, sterile; Knee (articular cavity); Rabbit; 2002; 2, 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; peptides; animal info (male, Japanese White, 3-3.4 kg., adolescent).

P7605 Alos,N., Ecarot,B. Downregulation of osteoblast Phex expression by PTH. Bone 2005; 37(-4-):589-598. >>> Parathyroid hormone, rat (1-34); Sodium chloride; cysteine; SC; Mice; 2001; 3 days; Controls received mp w/ vehicle; dose-response (fig. 8); peptides; animal info (C57BL/6J, 47 days old).

P7477 Bellido,T., Ali,A.A., Gubrij,I., Plotkin,L.I., Fu,Q., O'Brien,C.A., Manolagas,S.C., Jilka,R.L. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 2005; 146(-11-):4577-4583. >>> Parathyroid hormone, human 1-84; Saline; acetic acid; mercaptoethanol, B-; Mice; 4 days; Controls received mp w/ vehicle; functionality of mp verified by hpTH and mPTH ELISA; comparison of daily injections vs. mp; peptides; animal info (female, Swiss Webster).

P6897 Healy,K.D., Vanhooke,J.L., Prahl,J.M., DeLuca,H.F. Parathyroid hormone decreases renal vitamin D receptor expression in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-13-):4724-4728. >>> Parathyroid hormone (1-34), recomb. human; Saline; Mice; 48 hours; Controls received mp w/ vehicle.

P7712 Iida-Klein,A., Lu,S.S., Kapadia,R., Burkhart,M., Moreno,A., Dempster,D.W., Lindsay,R. Short-term continuous infusion of human parathyroid hormone 1-34 fragment is catabolic with decreased trabecular connectivity density accompanied by hypercalcemia in C57BL/J6 mice. Journal of Endocrinology 2005; 186(-3-):549-557. >>> Parathyroid hormone, human 1-34; PBS; acetic acid; SC; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by hPTH 1-34 serum levels; comparison of SC injections vs. mp; no stress (see pg. 553, 556); peptides; animal info (female, C57BL/J6, 10 wk. old, 18 g); "No animals showed abnormal movements or signs of stress or discomfort at any point in any experiment." (p. 553).

P7274 Kulkarni,N.H., Halladay,D.L., Miles,R.R., Gilbert,L.M., Frolik,C.A., Galvin,R.J.S., Martin,T.J., Gillespie,M.T., Onyia,J.E. Effects of parathyroid hormone on Wnt signaling pathway in bone. Journal of Cellular Biochemistry 2005; 95(-6-):1178-1190. >>> Parathyroid hormone, human 1-38; PBS; serum, rat; SC; Rat; 2001D; 1, 3, 6, 24 hours; Controls received mp w/ vehicle; replacement therapy (parathyroidectomy).

P7500 Lotinun,S., Sibonga,J.D., Turner,R.T. Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 2005; 146(-9-):4074-4081. >>> Parathyroid hormone, human 1-34; thymidine, methyl -3H; Sodium chloride; HCl; serum, rat; ethanol; SC; Rat; 1, 2, 4 weeks; 1, 3, 5 days; Controls received mp w/ vehicle; functionality of mp verified by serum PTH; pumps replaced after 2 weeks; stability verified; peptides; multiple pumps per animal (2); animal info (female, Sprague-Dawley, 260 g); 2% ethanol.

P7487 Meehan,T.F., Vanhooke,J., Prahl,J., DeLuca,H.F. Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice. Archives of Biochemistry and Biophysics 2005; 442(-2-):214-221. >>> Parathyroid hormone, human 1-34; Sodium chloride; HCl; serum, mouse heat inactivated; SC; Mice; 1002; 15 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; peptides; neurodegenative (multiple sclerosis); animal info (1a-hydroxylase knockout, male, female).

P7527 Thota,C.S., Reed,L.C., Yallampalli,C. Effects of parathyroid hormone like hormone (PTHLH) antagonist, PTHLH7-34 on fetoplacental development and growth during midgestation in rats. Biology of Reproduction 2005; 73(-6-):1191-1198. >>> Parathyroid hormone-like hormone 7-34; Saline; SC; Rat (pregnant); 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig. 1); teratology; peptides; animal info (pregnant, female, 37 days old); PTHLH antagonist.

P7638 Van Abel,M., Hoenderop,J.G.J., van der Kemp,A.W.C.M., Friedlaender,M.M., van Leeuwen,J.P.T.M., Bindels,R.J.M. Coordinated control of renal Ca2+ transport proteins by parathyroid hormone. Kidney International 2005; 68(-4-):1708-1721. >>> Parathyroid hormone, bovine 1-34; NPS R-467; Cystein HCl; cyclodextrin, 2 hydroxypropyl-beta; SC; Rat; mice; 1007D; 2001; 7 days; Controls received mp w/ vehicle; replacement therapy (parathyroidectomy); dose-response (table 3); animal info (C57BL, male, sabra 250 g, 8 wk old); 45% cyclodextrin used.

P6617 Katsumata,S., Masuyama,R., Koshihara,M., Matsuzaki,H., Uehara,M., Suzuki,K. High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2004; 68(-1-):243-246. >>> Parathyroid hormone (1-34); Saline; SC; Rat; 2002; ; Controls received mp w/ vehicle; PTH plasma levels taken; replacement therapy (parathyroidectomy); peptides.

P6909 Lotinun,S., Evans,G.L., Bronk,J.T., Bolander,M.E., Wronski,T.J., Ritman,E.L., Turner,R.T. Continuous parathyroid hormone induces cortical porosity in the rat: Effects on bone turnover and mechanical properties. Journal of Bone and Mineral Research 2004; 19(-7-):1165-1171. >>> Parathyroid hormone, recomb. human; SC; Rat; 1-28 days; Controls received mp w/ vehicle.

P6760 Neves,K.R., Graciolli,F.G., dos Reis,L.M., Pasqualucci,C.A., Moyses,R.M.A., Jorgetti,V. Adverse effects of hyperphosphatemia on myocardial hypertrophy, renal function, and bone in rats with renal failure. Kidney International 2004; 66(-6-):2237-2244. >>> Parathyroid hormone, rat 1-34; Cysteine; Rat; 2ML4; 8 weeks; Controls received mp w/ vehicle; replacement therapy (parathyroidectomy, 5/6 nephrectomy); long-term study; pumps replaced at day 28.

P6410 Onyia,J.E., Galvin,R.J.S., Ma,Y.F.L., Halladay,D.L., Miles,R.R., Yang,X.H., Fuson,T., Cain,R.L., Zeng,Q.Q., Chandrasekhar,S., Emkey,R., Xu,Y.P., Thirunavukkarasu,K., Bryant,H.U., Martin,T.J. Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption. Journal of Pharmacology and Experimental Therapeutics 2004; 309(-1-):369-379. >>> Parathyroid hormone, human; Saline; serum; SC; Rat; 56 hours; Replacement therapy (parathyroidectomy); pump model not listed.

P6275 Wlodek,M.E., Di Nicolantonio,R., Westcott,K.T., Farrugia,W., Ho,P.W.M., Moseley,J.M. PTH/PTHrP receptor and mid-molecule PTHrP regulation of intrauterine PTHrP: PTH/PTHrP receptor antagonism increases SHR fetal weight. PLACENTA 2004; 25(-1-):53-61. >>> Parathyroid hormone-related protein (1-34); parathyroid hormone-related protein (67-94); parathyroid hormone-related protein (7-34), [Asn10, Leu11]; Saline; BSA; Intrauterine; Rat (pregnant); 2002; 10 days; Controls received mp w/ vehicle; teratology; 2% BSA added; pump placed in IP cavity.

P6828 Yuan,B.Z., Xing,Y., Horst,R.L., Drezner,M.K. Evidence for abnormal translational regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in the Hyp-mouse. Endocrinology 2004; 145(-8-):3804-3812. >>> Parathyroid hormone, bovine 1-34; calcitonin, salmon; Saline, physiological; cysteine hydrochloride; SC; Mice; 1003D; 2001; 12 hours; Controls received mp w/ vehicle.

P6198 Arai,S., Amizuka,N., Azuma,Y., Takeshita,S., Kudo,A. Osteoclastogenesis-related antigen, a novel molecule on mouse stromal cells, regulates osteoclastogenesis. Journal of Bone and Mineral Research 2003; 18(-4-):686-695. >>> Parathyroid hormone; SC; Mice; 4 days; Controls received mp w/ PBS.

P6475 Bellido,T., Ali,A.A., Plotkin,L.I., Fu,Q., Gubrij,I., Roberson,P.K., Weinstein,R.S., O'Brien,C.A., Manolagas,S.C., Jilka,R.L. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts - A putative explanation for why intermittent administration is needed for bone anabolism. Journal of Biological Chemistry 2003; 278(-50-):50259-50272. >>> Parathyroid hormone, human 1-84; Saline; acetic acid; mercaptoethanol, 2-; SC; Mice; 1003D; 1007D; 2,4,6 days; 6,18,48 hours; Controls received no treatment; functionality of mp verified by serum hormone levels; dose-response (fig.1); comparison of SC injections vs. mp; no stress (see pg.50260); peptides.

P5626 Fujiwara,I., Aravindan,R., Horst,R.L., Drezner,M.K. Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase a ctivity in X-linked hypophosphatemia: A translational or post-translational defect. Journal of Bone and Mineral Research 2003; 18(-3-):434-442. >>> Parathyroid hormone (1-34); Saline; cysteine hydrochloride; SC; Mice; 2001; 12 hours; Controls received mp w/ vehicle; peptides; (PTH, bovine).

P6251 Kanazawa,K., Azuma,Y., Nakano,H., Kudo,A. TRAF5 functions in both RANKL- and TNF alpha-induced osteoclastogenesis. Journal of Bone and Mineral Research 2003; 18(-3-):443-450. >>> Parathyroid hormone; SC; Mice; 7 days; Controls received mp w/ PBS.

P5783 Lotinun,S., Sibonga,J.D., Turner,R.T. Triazolopyrimidine (trapidil), a platelet-derived growth factor antagonist, inhibits parathyroid bone disease in an animal model for chronic hyperparathyroidism. Endocrinology 2003; 144(-5-):2000-2007. >>> Parathyroid hormone (1-34); SC; Rat; 6 days; Controls received mp w/ vehicle; peptides.

P6246 Staal,A., Frith,J.C., French,M.H., Swartz,J., Gungor,T., Harrity,T.W., Tamasi,J., Rogers,M.J., Feyen,J.H. The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. Journal of Bone and Mineral Research 2003; 18(-1-):88-96. >>> Parathyroid hormone, human 1-34; SC; Rat; 3 days; Functionality of mp verified by plasma Ca concentration; replacement therapy (Thyro-parathyroidectomy); peptides.

P6247 Suda,T., Ueno,Y., Fujii,K., Shinki,T. Vitamin D and bone. Journal of Cellular Biochemistry 2003; 88(-2-):259-266. >>> Parathyroid hormone; Rat; 14 days; Functionality of mp verified by serum PTH levels; replacement therapy (thyroparathyroidectomy); peptides.

P5590 Gevers,E.F., Loveridge,N., Robinson,I.C.A.F. Bone marrow adipocytes: A neglected target tissue for growth hormone. Endocrinology 2002; 143(-10-):4065-4073. >>> Growth hormone; Insulin-like growth factor I; Parathyroid hormone (1-34); BSA; water; SC; rat; 2002; 2 weeks; replacement therapy (genetically GH-deficient rats); peptides.

P5054 Miles,R.R., Sluka,J.P., Halladay,D.L., Santerre,R.F., Hale,L.V., Bloem,L., Patanjali,S.R., Galvin,R.J.S., Ma,L., Hock,J.M., Onyia,J.E. Parathyroid hormone (hPTH 1-38) stimulates the expression of UBP41, an ubiquitin-specific protease, in bone. Journal of Cellular Biochemistry 2002; 85(--):229-242. >>> Parathyroid Hormone (1-38); Saline, acidified; Serum, rat; SC; rat; 2001D; 1, 3, 6, 24 hours; replacement therapy (thyroidectomy p. 231); comparison of sc injections vs. mp; peptides; pump model incorrectly stated as 20011, specifications correspond to 2001D; synthetic human PTH used; rat serum was heat-inactivated.

P6319 Dani,B.A., DeLuca,P.P. Skeletal Effects of Parathyroid Hormone (1-34) in Ovariectomized Rats With or Without Concurrent Administration of Salmon Calcitonin. Pharmsci 2001; 3(-4-):1-7. >>> Parathyroid hormone, human 1-34; calcitonin, salmon; Acetate buffer; saline; SC; Rat; 2004; 28 days; Controls received mp w/ vehicle or sham ovx + mp w/ vehicle; functionality of mp verified by serum levels; replacement therapy (ovariectomy); comparison of daily PTH sc injections vs. mp; peptides.

P4897 Friedlaender,M.M., Wald,H., Dranitzki-Elhalel,M., Zajicek,H.K., Levi,M., Popovtzer,M.M. Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal P-i handling. American Journal of Physiology-Renal Physiology 2001; 281(--):F428-F433. >>> Parathyroid hormone (1-34), bovine; Hydroxycholecalciferol, 25-; Cysteine HCl; Propylene glycol; SC; Rat; 2001; 7 days; controls received mp w/ vehicle; replacement therapy (parathyroidectomy); vitamin D, calcium; Pumps implanted without priming; 25-hydroxycholecalciferol, also called 1, 25-(OH)2D3, is a precursor of vitamin D, which is related to calcium absorption and parathyroid hormone release. PTH was delivered in 2% cysteine HCl, 25-hydroxycholecalciferol wa delivered in propylene glycol..

P5024 Ma,Y.F.L., Cain,R.L., Halladay,D.L., Yang,X.H., Zeng,Q.Q., Miles,R.R., Chandrasekhar,S., Martin,T.J., Onyia,J.E. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 2001; 142(-9-):4047-4054. >>> Parathyroid hormone; Saline, acidified; Rat serum;; SC; rat; 2001D; 1, 3, 6, 24 hours; controls received sham parathyroidectomy, mp w/ vehicle; replacement therapy (parathyroidectomy); dose reponse (p. 4049 fig. 1); peptides; PTH was synthetic human; rat serum was 2%, heat-inactivated.

P4981 Nakchbandi,I.A., Mitnick,M.A., Masiukiewicz,U.S., Sun,B.H., Insogna,K.L. IL-6 negatively regulates IL-11 production in vitro and in vivo. Endocrinology 2001; 142(--):3850-3856. >>> Parathyroid hormone, human 1-84; mice; 5 days; functionality of mp verified by serum PTH levels; hyperparathyroidism.

P4883 Zhou,H., Shen,V., Dempster,D.W., Lindsay,R. Continuous parathyroid hormone and estrogen administration increases vertebral cancellous bone volume and cortical width in the estrogen-deficient rat. Journal of Bone and Mineral Research 2001; 16(--):1300-1307. >>> Parathyroid hormone (1-34); Acetic acid; SC; rat; 2002; 4 weeks; controls received mp w/ vehicle; dose response (graphs p. 1303); no stress: "We saw no evidence of a deleterious effect of continuous PTH treatment..." p. 1304; peptides.

P6716 Gunther,T., Chen,Z-F, Kim,J., Priemel,M., Rueger,J.M., Amling,M., Moseley,J.M., Martin,T.J., Anderson,D.J., Karsenty,G. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 2000; 406(--):199-203. >>> Parathyroid hormone, human 1-34; Sodium chloride; BSA; cysteine; HCL; SC; Mice; 8 days; Controls received mp w/ vehicle; replacement therapy (hypoparathyroidism); peptides.

P4654 Masiukiewicz,U.S, Mitnick,M., Grey,A.B, Insogna,K.L. Estrogen modulates parathyroid hormone-induced interleukin-6 production in vivo and in vitro.. Endocrinology 2000; 141(-7-):2526-2531. >>> Parathyroid hormone, human 1-84;; SC;; mice;; 5 days;; Controls received mp w/ vehicle;.

P5246 Shakespeare,W., Yang,M., Bohacek,R., Cerasoli,F., Stebbins,K., Sundaramoorthi,R., Azimioara,M., Vu,C., Pradeepan,S., Metcalf,C.,III, Haraldson,C., Merry,T., Dalgarno,D., Narula,S., Hatada,M., Lu,X., van Schravendijk,M.R., Adams,S., Violette,S., Smith,J., Guan,W., Bartlett,C., Herson,J., Iuliucci,J., Weigele,M., Sawyer,T. Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc.Natl.Acad.Sci.U.S A 2000/8/15; 97(-17-):9373-9378. >>> Parathyroid hormone (1-34); SC; Rat; 2002; 15 days; Replacement therapy (thyroidectomy, parathyroidectomy); bovine PTH used; bone resorption model.

P5003 Shen,V., Birchman,R., Wu,D.D., Lindsay,R. Skeletal effects of parathyroid hormone infusion in ovariectomized rats with or without estrogen repletion. J.Bone Miner.Res 2000/4; 15(-4-):740-746. >>> Parathyroid hormone, (1-34) rat; Acetic acid; SC; rat; 2002; 2-4 weeks; controls received mp w/ vehicle; functionality of mp verified by serum PTH levels; pumps replaced after 2 weeks; ovariectomized rats given estrogen replacement by pellets; vehicle concentration was 1mM acetic acid.

P4614 Silva,I.V, Blaisdell,C.J, Guggino,S.E, Guggino,W.B  Am.J.Physiological.Renal Physiol. 2000; 278(--):F238-F245. >>> Vitamin D; Parathyroid hormone (1-34);; Ringer's solution;; SC;; rat (pregnant);; 1003D;; 3 days;; controls received mp w/vehicle + sham operation; replacement therapy (thyroparathyroidectomy); peptides;.

P5112 Fox,J., Lowe,S.H., Conklin,R.L., Petty,B.A., Nemeth,E.F. Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca2+ receptor in rats. Journal of Pharmacology and Experimental Therapeutics 1999; 290(-2-):480-486. >>> Parathyroid hormone (1-34); Cysteine HCl; SC; rat; 2001; 5-7 days; controls received sham surgery; replacement therapy (parathyroidectomy); peptides; synthetic rat PTH infused; functionality of mp verified by plasma PTH; vehicle was 2% cysteine HCL at pH 1.5.

P4565 Jara,A, Lee,E, Stauber,D, Moatamed,F, Felsenfeld,A.J., Kleeman,C.R  Kidney International 1999; 55(--):1434-1443. >>> Parathyroid hormone 1-34; SC;; rat;; 2001;; 48 hours;; each pump was reused in 3 different rats;.

P4515 Kostenuik,P.J, Harris,J, Halloran,B.P., Turner,R.T., Morey-Holton,E.R., Bikle,D.D. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.. Journal of Bone and Mineral Research 1999; 14(-1-):21-31. >>> Parathyroid hormone (1-34);; NaCl; HCl; Serum, rat; Saline; Sesame oil;; SC;; rat;; 2001;; 8 days;; controls received mp w/vehicle; peptides; pulsatile administration; PE-60 was filled with sesame oil interspersed with PTH or with vehicle; pumps filled with saline; PTH was designed to be delivered for 1 hr per day for 8 days..

P5288 Morley,P., Whitfield,J.F., Willick,G.E., Ross,V., MacLean,S., Isaacs,R.J., Mendoza,E., Barbier,J.R. Prolonged low-dose infusion of human parathyroid hormone does not increase femoral cancellous bone volume in ovariectomized rats. Eur.J Endocrinol 1999/7; 141(-1-):70-74. >>> Parathyroid hormone (1-31); Saline; HCl; SC; Rat; 2002; 6 weeks; Controls received mp w/ vehicle; comparison of sc injections vs. mp; pumps replaced every 2 weeks; peptides.

P5570 Soma,S., Iwamoto,M., Higuchi,Y., Kurisu,K. Effects of continuous infusion of PTH on experimental tooth movement in rats. J.Bone Miner.Res. 1999/4; 14(-4-):546-554. >>> Parathyroid hormone, human 1-84; parathyroid hormone (I-34); Saline, citrate-buffered; Tween 80; SC; Rat; 2ML1; 2, 3, 5, 7 days; Controls received mp w/ vehicle; comparison of daily SC injections vs mp; 0.05% Tween-80 used in vehicle.

P4473 Szabo,A., Freesmeyer,M.G, Abendroth,K, Stein,G, Rosivall,L., El-Shakmak,A., Ritz,E. Physiological doses of calcium regulatory hormones do not normalize bone cells in uraemic rats.. European Journal of Clinical Investigation 1999; 29(--):529-535. >>> Parathyroid hormone 1-34; Calcitrol;; Cysteine; Propylene glycol; Saline;; rat;; 2002;; 14 days;; controls received mp w/vehicle; replacement therapy (parathyroidectomy; nephrectomy); peptides;.

P4562 Watson,P.H, Fraher,L.J, Kisiel,M, DeSouza,D., Hendy,G, Hodsman,A.B  Bone 1999; 24(--):89-94. >>> Parathyroid hormone, human 1-84;; Saline; Rat serum;; rat;; 2ML2;; 7 days;; controls received mp w/vehicle; peptides;.

P4564 Berdud,I., Martin-Malo,A, Almaden,Y., Aljama,P., Rodriguez,M., Felsenfeld,A.J. The PTH-calcium relationship during a range of infused PTH doses in the parathyroidectomized rat.. Calcif.Tissue Int. 1998; 62(--):457-461. >>> Parathyroid hormone 1-34;; Saline, isosmotic; Cysteine;; SC;; rat;; 2001;; 48 hours;; controls received mp w/vehicle; dose response (p. 457, 458); peptides; each pump was used in 3 different rats..

P4540 Hirsch,P.F, Imai,Y., Hosoya,Y, Ode,H, Maeda,S  Endocrine 1998/2; 8(-1-):29-36. >>> Parathyroid hormone (1-34);; rat serum; cysteine;; SC;; rat;; 2001;; 7 days;; controls received mp w/vehicle; peptides;.

P3929 Tordoff,M.G., Hughes,R.L., Pilchak,D.M. Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D. Am.J.Physiol. 1998; 274(-43-):R214-R231. >>> Parathyroid hormone; Calcitonin; Vitamin D, 1,25-dihydroxy-; NaCl; HCl; Cysteine; Saline, isotonic; SC; rat; 2002; 13 days; controls received sham tubing; functionality of mp verified by hormone assays; replacement therapy (thyroidectomy, thyroparathyroidectomy); dose-response; stress/adverse reaction: high doses led to animal death; peptides; agents given singly and in combination.

P4421 Turner,R.T., Evans,G.L, Cavolina,J.M, Halloran,B, Morey-Holton,E. Programmed administration of parathyroid hormone increases bone formation and reduces bone loss in hindlimb-unloaded ovariectomized rats.. Endocrinology 1998; 139(--):4086-4091. >>> Parathyroid hormone, human 1-34; NaCl; HCl; Serum, rat;; SC;; rat;; 7 days;; controls received mp w/vehicle; replacement therapy (overiectomized); peptides; pulsed delivery; PTH during a daily 1-hour infusion for 7 days.

P3802 Dobnig,H., Turner,R.T. The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. Endocrinology 1997; 138(-11-):4607-4612. >>> Parathyroid hormone, human 1-34; NaCl; HCI; Serum, rat; rat; 2001; 6 days; controls received mp w/vehicle; comparison of sc injections vs mp; pulsed delivery, sesame oil used in lynch coil; no stress (see pg. 4609); stress/adverse reaction: high PTH dose lethal for 3/7 rats in first group; good methods (pg. 4608).

P3718 Sun,B.H., Mitnick,M., Eielson,C., Yao,G.Q., Paliwal,I., Insogna,K. Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy. Endocrinology 1997; 138(-9-):3918-3924. >>> Parathyroid hormone, human 1-34; Parathyroid hormone, human 1-84; Cysteine HCl; SC; rat; 72 hours; replacement therapy (ovariectomy, parathyroidectomy); no stress (see pg. 3920); peptides; vehicle used at pH 1.5.

P3699 Berdud,I., Martin-Malo,A., Almaden,Y., Tallon,S., Concepcion,M.T., Torres,A., Felsenfeld,A., Aljama,P., Rodrigues,M. Abnormal calcaemic response to PTH in the uraemic rat without secondary hyperparathyroidism. Nephrol.Dial.Transplant 1996; 11(--):1292-1298. >>> Parathyroid hormone 1-34; SC; rat; 2001; 2002; 14 days; 48 hours; replacement therapy (parathyroidectomy); preliminary 14-day experiment done to assess proper PTH dose.

P3708 Tallon,S., Berdud,I., Hernandez,A., Concepcion,M.T., Almaden,Y., Torres,A., Martin-Malo,A., Felsenfeld,A.J., Aljama,P., Rodriguez,M. Relative effects of PTH and dietary phosphorus on calcitriol production in normal and azotemic rats. Kidney Int. 1996; 49(--):1441-1446. >>> Parathyroid hormone, rat 1-34; Saline, isotonic; Cysteine; SC; rat; 2002; 14 days; replacement therapy (parathyroidectomy); physiological activity of PTH reached when infused at a dose of .022 ug/hr/100g body weight.

P3606 Tsuji,H., Cawthorn,C., Ecarot,B. Abnormal modulation of serum osteocalcin by dietary phosphate and 1,25-dihydroxyvitamin D3 in the hypophosphatemic mouse. J.Bone and Min.Res. 1996; 11(-9-):1234-1240. >>> Parathyroid hormone; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; Saline; Cysteine; SC; mice; 2001; 3,14 days; controls received mp w/ vehicle; peptides.

P3677 Amann,K., Tornig,J., Flechtenmacher,Ch., Nabakov,A., Mall,G., Ritz,E. Blood-pressure-independent wall thickening of intramyocardial arterioles in experimental uraemia: evidence for a permissive action of PTH. Nephrol.Dial.Transplant 1995; 10(--):2043-2048. >>> Parathyroid hormone 1-34; Saline; SC; rat; 14 days; controls received mp w/ saline or received no treatment or were sham operated; replacement therapy (parathyroidectomy); rats were also sublotally nephrectomized.

P2801 Lin,J.-R., Bekersky,I., Brown,N.S., Mong,S., Lee,F., Newman,R.A., Ho,D.H. Normocalcemic effect of gallium nitrate in hypercalcemic rat model. Cancer Res. 1995; 55(--):307-311. >>> Parathyroid hormone; NaCl; SC; rat; 2001; 7 days; replacement therapy (parathyroidectomy); cancer.

P3389 Saxe,A.W., Gibson,G., Gingerich,R.L., Levy,J. Parathyroid hormone decreases in vivo insulin effect on glucose utilization. Calcif.Tissue Int. 1995; 57(--):127-132. >>> Parathyroid hormone (1-34); Cysteine HCl; NaCl; SC; rat; 2001; 5 days; controls received mp w/vehicle; peptides.

P3393 Uchimoto,S., Tsumura,K., Kishimoto,H., Yamashita,N., Morii,H. Implication of parathyroid hormone for the development of hypertension in young spontaneously hypertensive rats. Miner Electrolyte Metab. 1995; 21(--):82-86. >>> Parathyroid hormone (1-34); Saline; SC; rat; 2002; 2 weeks; controls received mp w/saline; replacement therapy (parathyroidectomy); peptides.

P3052 Yamamoto,M., Seedor,J.G., Rodan,G.A., Balena,R. Endogenous calcitonin attenuates parathyroid hormone-induced cancellous bone loss in the rat. Endocrinology 1995; 136(-2-):788-795. >>> Parathyroid hormone, bovine 1-34; NaCl; Cysteine HCl; SC; rat; 2001; 3 days; controls received mp with vehicle; replacement therapy (parathyroidectomy); peptides.

P2595 Amann,K., Ritz,E., Wiest,G., Klaus,G., Mall,G. A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia. J.Am.Soc.Nephrol. 1994; 4(-10-):1814-1819. >>> Parathyroid hormone, rat 1-34; Sodium chloride; SC; rat; 2ML2; 14 days; controls received mp w/ vehicle or sham operation; replacement therapy (parathyroidectomy); peptides.

P2300 Kukreja,S.C., D'Anza,J.J., Wimbiscus,S.A., Fisher,J.E., McKee,R.L., Caulfield,M.P., Rosenblatt,M. Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy. Endocrinology 1994; 134(-5-):2184-2188. >>> Parathyroid hormone antagonist; Acetic acid; Albumin, bovine serum; Cysteine; Saline; SC; mice (nude); 2001; 48 hours; cancer; peptides; iv infusion vs. sc.

P3236 Long,J.F., Nagode,L.A., Steinmeyer,C.L., Renkes,G. Comparative effects of calcitriol and parathyroid hormone on serum aluminum in vitamin D-depleted rabbits fed an aluminum-supplemented diet. Res.Commun.Chem.Pathol.Pharmacol. 1994; 83(-1-):3-14. >>> Calcitriol; Parathyroid hormone (1-34); Cysteine; HCI; Saline; rabbit; 7 days; functionality of mp verified by serum levels; peptides.

P2268 Fisher,J.E., Caulfield,M.P., Sato,M., Quartuccio,H.A., Gould,R.J., Garsky,V.M., Rodan,G.A., Rosenblatt,M. Inhibition of osteoclastic bone resorption in vivo by echistatin, an 'arginyl-glycyl-aspartyl' (RGD) - containing protein. Endocrinology 1993; (--):-. >>> Parathyroid hormone, bovine; SC; rat; 2001D; 6 hours; replacement therapy (thyroparathyroidectomy).

P2462 Guise,T.A., Yoneda,T., Yates,A.J., Mundy,G.R. The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-a enhance hypercalcemia in vivo and bone resorption in vitro. J.Clin.Endocrinol.Metab. 1993; 77(-1-):40-45. >>> Parathyroid hormone-like protein; PBS; Albumin, bovine serum; SC; mice; 1003D; 3 days; peptides.

P2551 Kishimoto,H., Tsumura,K., Fujioka,S., Uchimoto,S., Morii,H. Chronic parathyroid hormone administration reverses the antihypertensive effect of calcium loading in young spontaneously hypertensive rats. Am.J.Hypertens. 1993; 6(-3-):234-240. >>> Parathyroid hormone, human; Saline; SC; rat; 2002; 2 weeks; controls received mp w/ saline; functionality of mp verified by RIA; peptides.

P3215 Kukreja,S.C., Rosol,T.J., D'Anza,J.J., Wimbiscus,S.A. Effect of transforming growth factor alpha, parathyroid hormone-related protein, or their combination on bone histomorphometry. Bone and Mineral 1993; 23(--):105-111. >>> Transforming growth factor-a; Parathyroid hormone-related peptide (1-34); Acetic acid; Saline; Cysteine; Albumin, bovine serum; mice; 2001; 6 days; controls received mp with vehicle; functionality of mp verified; peptides; peptides given singly and concomitantly; some animals received 2 mps; recomb. human TGF-a used.

P3244 Lin,J.H., Chen,I.W., deLuna,F.A., Hichens,M. Role of calcium in plasma protein binding and renal handling of alendronate in hypo- and hypercalcemic rats. J.Pharmacol.Exp.Ther. 1993; 267(-2-):670-675. >>> Parathyroid hormone; rat; 1003D; 18 hours; replacement therapy (thyroparathyroidectomy); peptides.

P3576 Tordoff,M.G., Hughes,R.L., Pilchak,D.M. Independence of salt intake from the hormones regulating calcium homeostasis. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.33) 1993; 264(--):R500-R512. >>> Parathyroid hormone, bovine; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2001; 2002; 1, 2 weeks; replacement therapy (thyroparathyroidectomy).