References on the Administration of Parathyroid Hormone Using ALZET® Osmotic Pumps

16198 Li, J. Y., D'Amelio, P., Robinson, J., Walker, L. D., Vaccaro, C., Luo, T., Tyagi, A. M., Yu, M., Reott, M., Sassi, F., Buondonno, I., Adams, J., Weitzmann, M. N., Isaia, G. C., Pacifici, R. IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice. Cell Metab 2015; 22(-5-):799-810. >>> Parathyroid hormone, human (1-34); SC; mice; 1002; Controls received mp w/ vehicle; animal info: 16-week-old female mice, C57BL/6 WT; functionality of mp verified by flow cytometry; dose-response (pg 808); replacement therapy (human parathyroid hormone); immunology; peptides; Dose: 80 mg/kg/day.

16190 Iwasaki, Y., Kazama, J. J., Yamato, H., Matsugaki, A., Nakano, T., Fukagawa, M. Altered material properties are responsible for bone fragility in rats with chronic kidney injury. Bone 2015; 81(--):247-54. >>> Parathyroid hormone, rat; SC; rat; 2002; Controls received sham operation; animal info: 12-week-old male Sprague-Dawley; functionality of mp verified by urine samples; pumps replaced every 2 weeks; pumps replaced every 2 weeks; long-term study; Dose: 0.1Ǩg/kg/h.

15798 Stuart Maudsley, Bronwen Martin, Jonathan Janssens, Harmonie Etienne, Areta Jushaj, Jaana van Gastel, Ann Willemsen, Hongyu Chen, Diane Gesty-Palmer, Louis M. Luttrell  Methods 2016; 92(--):51-63. >>> Parthyroid hormone (1-34), human; parathyroid hormone (7-34), bovine; PBS; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57Bl6J, 11 weeks old); Dose (all PTH 40 ug/kg/day);.

15204 Chaichanasakul, T., Kang, B., Bezouglaia, O., Aghaloo, T.L., Tetradis, S., Tetradis, S. Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone1116. JOURNAL OF PERIODONTOLOGY 2014; 85(--):829-836. >>> Parathyroid hormone (1-34), human; vitamin D3, 1,25-dihydroxy; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 3 months old);.

15038 Maudsley, S., Martin, B., Gesty-Palmer, D., Cheung, H., Johnson, C., Patel, S., Becker, K.G., Wood, WH III, Zhang, Y.Q., Lehrmann, E., Luttrell, L.M., Maudsley, S. Delineation of a Conserved Arrestin-Biased Signaling Repertoire In Vivo. MOLECULAR PHARMACOLOGY 2015; 87(--):706-717. >>> Parathyroid hormone (1-34), human; parathyroid hormone (7-34), bovine; PBS; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, WT or congenic arrestin3 null, 11 weeks old);.

15250 Lam, V., Takechi, R., Pallabage-Gamarallage, M., Giles, C., Mamo, J.C.L., Mamo, J.C.L. The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders. PLoS One 2015; 10(--):U4547-U4566. >>> Parathyroid hormone (1-34); Saline, isosmotic; cysteine; SC; Rat; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 7 weeks old); functionality of mp verified by residual volume and serum levels; 2% cysteine used; replacement therapy (parathyroid replacement); used wound clips; used 2ML size pumps; pumps primed; long-term study;.

14893 Choudhary, S., Canalis, E., Estus, T., Adams, D., Pilbeam, C., Pilbeam, C. Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice. PLoS One 2015; 10(--):U2183-U2203. >>> Parathyroid hormone (1-34), human; HCl; BSA, PBS; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, Cox2KO or wt, 3 months old); 0.1% BSA used; pumps primed for 6 hours in 37C saline;.

14829 Babey, M., Wang, Y.M., Kubota, T., Fong, C., Menendez, A., ElAlieh, H.Z., Bikle, D.D., Babey, M. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH 2015; 30(--):1064-1076. >>> Parathyroid hormone (1-34); NaCl; HCl; serum, heat-inactivated mouse; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (FVN/B12 weeks old); functionality of mp verified by serum PTH levels; cardiovascular;.

14370 Roche, B., Vanden-Bossche, A., Malaval, L., Normand, M., Jannot, M., Chaux, R., Vico, L., Lafage-Proust, M.H., Lafage-Proust, M.H. Parathyroid Hormone 1-84 Targets Bone Vascular Structure and Perfusion in Mice: Impacts of Its Administration Regimen and of Ovariectomy. Journal of Bone and Mineral Research 2014; 29(--):1608-1618. >>> Parathyroid hormone (1-84); SC; Mice; Controls received mp w/ vehicle; animal info (female, C57BL6, 4 months old, ovariectomized); comparison of injection vs mp; cardiovascular;.

14739 Fumoto, T., Ito, M., Ikeda, K., Ikeda, K. Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover. JOURNAL OF BONE AND MINERAL METABOLISM 2014; 32(--):484-493. >>> Parathyroid hormone (1-34), rat; Rat; 2004; Controls received sham surgery; animal info (male, Sprague Dawley, 8 weeks old); long-term study;.

14674 Bozic, M., Panizo, S., Sevilla, M.A., Riera, M., Soler, M.J., Pascual, J., Lopez, I., Freixenet, M., Fernandez, E., Valdivielso, J.M., Valdivielso, J.M. High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin. Journal of Hypertension 2014; 32(--):1822-1832. >>> Parathyroid hormone (1-34), recombinant rat; SC; Rat; 2002; Animal info (Sprague Dawley, 200-225g); functionality of mp verified by calcium serum levels; replacement therapy (parathyroidectomy); cardiovascular;.

14570 Shimomura, A., Matsui, I., Hamano, T., Ishimoto, T., Katou, Y., Takehana, K., Inoue, K., Kusunoki, Y., Mori, D., Nakano, C., Obi, Y., Fujii, N., Takabatake, Y., Nakano, T., Tsubakihara, Y., Isaka, Y., Rakugi, H., Isaka, Y. Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats. Journal of the American Society of Nephrology 2014; 25(--):1954-1965. >>> Parathyroid hormone (1-34); Rat; animal info (6 wks old, male, Wistar); induction of nehphrocalcinosis.

13400 Krause, D.S., Fulzele, K., Catic, A., Sun, C.C., Dombkowski, D., Hurley, M.P., Lezeau, S., Attar, E., Wu, J.Y., Lin, H.Y., vieti-Pajevic, P., Hasserjian, R.P., Schipani, E., Van Etten, R.A., Scadden, D.T. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine 2013; 19(-11-):1513-+. >>> Parathyroid hormone, human (1-34); Saline; Mice (NSG); Controls received mp w/ vehicle; animal info (NSG; BALB/c); pumps replaced every 2 weeks; cancer (leukemia); immunology; peptides.

13388 Iwasaki, Y., Kazama, J.J., Yamato, H., Shimoda, H., Fukagawa, M. Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease. Bone 2013; 57(-2-):477-483. >>> Parathyroid hormone (1-34); SC; Rat; 2002; Animal info (male, Sprague Dawley, 13 weeks old, 350g); peptides.

13368 David, V., Dai, B., Martin, A., Huang, J.S., Han, X.B., Quarles, L.D. Calcium Regulates FGF-23 Expression in Bone. Endocrinology 2013; 154(-12-):4469-4482. >>> Parathyroid hormone (1-34); SC; Mice; Controls received mp w/ vehicle; animal info (Gcm2-/-); functionality of mp verified by PTH serum levels;.

13216 Saini, V., Marengi, D.A., Barry, K.J., Fulzele, K.S., Heiden, E., Liu, X., Dedic, C., Maeda, A., Lotinun, S., Baron, R., Pajevic, P.D. Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH. Journal of Biological Chemistry 2013; 288(-28-):20122-20134. >>> Parathyroid hormone; SC; Mice; 1002; Animal info (8-12 week old).

13045 Guo, J., Song, L.G., Liu, M.L., Segawa, H., Miyamoto, K.I., Bringhurst, F.R., Kronenberg, H.M., Jueppner, H. Activation of a Non-cAMP/PKA Signaling Pathway Downstream of the PTH/PTHrP Receptor Is Essential for a Sustained Hypophosphatemic Response to PTH Infusion in Male Mice. Endocrinology 2013; 154(-5-):1680-1689. >>> Parathyroid hormone (1-34), human; NaCl; HCl; serum, mouse, heat-activated; SC; Mice; 1002; Control animals received mp w/ vehicle; animal info (wt, DD, Npt 2a -/-, Npt2c -/-).

12995 Matsui, I., Hamano, T., Mikami, S., Inoue, K., Shimomura, A., Nagasawa, Y., Michigami, T., Ohnishi, T., Fujii, N., Nakano, C., Kusunoki, Y., Kitamura, H., Iwatani, H., Takabatake, Y., Kaimori, J., Matsuba, G., Okoshi, K., Kimura-Suda, H., Tsubakihara, Y., Rakugi, H., Isaka, Y. Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. American Journal of Physiology-Renal Physiology 2013; 304(-6-):F751-F760. >>> Parathyroid hormone (1-34); Saline, acidified; serum, rat, heat-activated; Rat; Animal info (Wistar, male, 6 wks old);.

12581 Qing, H., Ardeshirpour, L., Pajevic, P.D., Dusevich, V., Jaehn, K., Kato, S., Wysolmerski, J., Bonewald, L.F. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. Journal of Bone and Mineral Research 2012; 27(-5-):1018-1029. >>> Parathyroid hormone, related peptide (1-36); SC; Mice; 2002; Animal info (CD-1, 12 wks old); peptides.

12573 Atchison, D.K., Westrick, E., Szandzik, D.L., Gordish, K.L., Beierwaltes, W.H. Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2012; 303(-4-):E457-E463. >>> Parathyroid hormone related protein (1-34), rat; Cysteine HCl; saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 200-250 g); wound clips used.

12294 Yuan, Q., Sato, T., Densmore, M., Saito, H., Schueler, C., Erben, R.G., Lanske, B. Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho(-/-) Mice. PLoS Genetics 2012; 8(-5-):U694-U703. >>> Parathyroid hormone (1-34); Saline, sterile; Mice; 1004; Controls received mp w/ vehicle; animal info (Kl -/-, PTH +/-3 wks old); peptides.

12080 Custodio, M.R., Koike, M.K., Neves, K.R., dos Reis, L.M., Graciolli, F.G., Neves, C.L., Batista, D.G., Magalhaes, A.O., Hawlitschek, P., Oliveira, I.B., Dominguez, W.V., Moyses, R.M.A., Jorgetti, V. Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system. NEPHROLOGY DIALYSIS TRANSPLANTATION 2012; 27(-4-):1437-1445. >>> Parathyroid hormone (1-34), rat; Cysteine; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (Wistar, male, 280-320 g); pumps replaced after 28 days; long-term study.

12008 Kudo, S., Mizuta, H., Takagi, K., Hiraki, Y. Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling. OSTEOARTHRITIS AND CARTILAGE 2011; 19(-7-):886-894. >>> Parathyroid hormone (1-84), recomb. human; Saline, sterile; Knee (articular cavity); Rabbit; 2002; Controls received mp w/ vehicle; animal info (male, white, adolescent, Japanese, 3-3.4 kg); pulsatile delivery;"The program consisted of alternating segments of 5 ul PTH (50 ug/ml) solution and 5 ul sterile saline interrupted by 1 ul air bubbles."pg 888.

11979 Iwasaki, Y., Kazama, J.J., Yamato, H., Fukagawa, M. Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease. Bone 2011; 48(-6-):1260-1267. >>> Parathyroid hormone (1-34); SC; Rat; 2002; Animal info (Sprague Dawley, male, 13 wks old, 350 g); pumps replaced every 2 weeks.

11889 Turner, R.T., Iwaniec, U.T., Marley, K., Sibonga, J.D. The Role of Mast Cells in Parathyroid Bone Disease. Journal of Bone and Mineral Research 2010; 25(-7-):1637-1649. >>> Parathyroid hormone, human, (1-34); thymidine, methyl-3H; Ethanol; SC; Rat; mice; Controls received mp w/ vehicle; animal info (Sprague Dawley, 6 wks to 6 mo; DBA, adult); 2% ethanol used.

11829 Michaud, J., Naud, J., Ouimet, D., Demers, C., Petit, J.L., Leblond, F.A., Bonnardeaux, A., Gascon-Barre, M., Pichette, V. Reduced Hepatic Synthesis of Calcidiol in Uremia. Journal of the American Society of Nephrology 2010; 21(-9-):1488-1497. >>> Parathyroid hormone (1-34);; Cysteine hydrochloride; IV (jugular); Rat; 1003D; animal info (Sprague Dawley, male, 176-255 g, parathyroidectomy); replacement therapy (parathyroidectomy).

11820 Ardeshirpour, L., Brian, S., Dann, P., VanHouten, J., Wysolmerski, J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. Endocrinology 2010; 151(-12-):5591-5601. >>> Parathyroid hormone-related protein (1-36); Water, sterile; cysteine, L-, sterile; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (female, 10-13 wks old, CD1, virgin, ovariectomy).

11768 Yuan, Q., Sitara, D., Sato, T., Densmore, M., Saito, H., Schueler, C., Erben, R.G., Lanske, B. PTH Ablation Ameliorates the Anomalies of Fgf23-Deficient Mice by Suppressing the Elevated Vitamin D and Calcium Levels. Endocrinology 2011; 152(-11-):4053-4061. >>> Parathyroid hormone (1-34); Saline, sterile; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (Fgf -/-, Pth -/-, wt); peptides.

11744 Brown, A.J., Ritter, C.S. The Vitamin D Analog 1-alpha,25-Dihydroxy-2-beta-(3-Hydroxypropyloxy) Vitamin D3 (Eldecalcitol) is a Potent Regulator of Calcium and Phosphate Metabolism. Calcified Tissue International 2011; 89(-5-):372-378. >>> Parathyroid hormone (1-34); SC; Rat; Animal info (female, Sprague-Dawley, 225-250 g); replacement therapy (parathyroidectomy); functionality of mp verified by plasma PTH levels.

11719 Otto-Duessel, M., Brewer, C., Wood, J.C. Interdependence of cardiac iron and calcium in a murine model of iron overload. Translational Research 2011; 157(-2-):92-99. >>> Parathyroid hormone; SC; Mice; Controls received mp w/ no treatment; animal info (8 wks old, HJVKO); no stress"Animals in all groups seemed to tolerate treatments well."pg 94; stress/adverse effects"One animal with a PTH pump implant died unexpectedly 2 weeks postsurgery"pg 94.

11496 Lymperi, S., Ersek, A., Ferraro, F., Dazzi, F., Horwood, N.J. Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood 2011; 117(-5-):1540-1549. >>> Parathyroid hormone (1-34); PBS, sterile; acetic acid; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL/6, female, 8-12 wks old); functionality of mp verified by PTH 1-34 levels in the blood serum; post op. care (Baytril and Rimadyl).

11487 Lopez, I., Rodriguez-Ortiz, M.E., Almaden, Y., Guerrero, F., de Oca, A.M., Pineda, C., Shalhoub, V., Rodriguez, M., guilera-Tejero, E. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney International 2011; 80(-5-):475-482. >>> Parathyroid hormone; Saline, isosmotic; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Wistar, 200 g); replacement therapy (parathyroidectomy).

11377 Guo, J., Liu, M.L., Yang, D.H., Bouxsein, M.L., Saito, H., Galvin, R.J.S., Kuhstoss, S.A., Thomas, C.C., Schipani, E., Baron, R., Bringhurst, F.R., Kronenberg, H.M. Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation. Cell Metabolism 2010; 11(-2-):161-171. >>> Parathyroid hormone (1-34), human; NaCl; serum, mouse, heat-activated; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (C57BL/6, Dkk1 Tg, male, 12 wks old).

11128 Etoh, M., Yamaguchi, A. Repetition of continuous PTH treatments followed by periodic withdrawals exerts anabolic effects on rat bone. JOURNAL OF BONE AND MINERAL METABOLISM 2010; 28(-6-):641-649. >>> Parathyroid hormone; SC; Rat; 1007D; 1003D; Controls received mp w/ vehicle; animal info (9 wks old, Sprague-Dawley, female); pumps replaced every 1 week; comparison of once a week and 3-times a week injections vs sc mp;"Continuous PTH treatment as well as intermittent PTH treatment stimulates bone formation, but the former treatment enhances osteoclastic bone resorption that exceeds the stimulated bone formation."pg 647.

10958 Kurio, N., Shimo, T., Fukazawa, T., Takaoka, M., Okui, T., Hassan, N.M.M., Honami, T., Hatakeyama, S., Ikeda, M., Naomoto, Y., Sasaki, A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAX and IGF-IR in vitro and in vivo. Experimental Cell Research 2011; 317(-8-):1134-1146. >>> Parathyroid hormone-related peptide (1-34); Saline, physiological; cysteine, L-; SC; Mice (nude); 1007D; Controls received mp w/ vehicle; animal info (5 wls old, male, BALB/c); cancer; peptides.

10598 Tawfeek, H., Bedi, B., Li, J.Y., Adams, J., Kobayashi, T., Weitzmann, M.N., Kronenberg, H.M., Pacifici, R. Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss. PLoS One 2010; 5(-8-):U56-U69. >>> Parathyroid hormone (1-34), human; Mice; 1002; Controls received mp w/ vehicle; animal info (male, female, 16 wks old, C57BL/6 WT , TNF -/-).

10573 Lavi-Moshayoff, V., Wasserman, G., Meir, T., Silver, J., Naveh-Many, T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. American Journal of Physiology-Renal Physiology 2010; 299(-4-):F882-F889. >>> Parathyroid hormone (1-34), rat; Cysteine, L-; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (C57BL/J6, male, 5-6 wks old).

10277 Morte, B., Diez, D., Auso, E., Belinchon, M.M., Gil-Ibanez, P., Grijota-Martinez, C., Navarro, D., De Escobar, G.M., Berbel, P., Bernal, J. Thyroid Hormone Regulation of Gene Expression in the Developing Rat Fetal Cerebral Cortex: Prominent Role of the Ca2+/Calmodulin-Dependent Protein Kinase IV Pathway. Endocrinology 2010; 151(-2-):810-820. >>> Parathyroid hormone (1-84); calcitonin, rat; Acetate buffer; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-300 g); replacement therapy (parathyroidectomy).

10195 Berbel, P., Navarro, D., Auso, E., Varea, E., Rodriguez, A.E., Ballesta, J.J., Salinas, M., Flores, E., Faura, C.C., De Escobar, G.M. Role of Late Maternal Thyroid Hormones in Cerebral Cortex Development: An Experimental Model for Human Prematurity. Cerebral Cortex 2010; 20(-6-):1462-1475. >>> Parathyroid hormone, rat (1-84); calcitonin, rat; thyroxine; Acetate buffer; SC; Rat (pregnant); 2001; Teratology; peptides; animal info (Female, Wistar, 250-300 g); replacement therapy (parathyroidectomy).

10194 Batista, D.G., Neves, K.R., Graciolli, F.G., dos Reis, L.M., Graciolli, R.G., Dominguez, W.V., Neves, C.L., Magalhaes, A.O., Custodio, M.R., Moyses, R.M., Jorgetti, V. The Bone Histology Spectrum in Experimental Renal Failure: Adverse Effects of Phosphate and Parathyroid Hormone Disturbances. Calcified Tissue International 2010; 87(-1-):60-67. >>> Parathyroid hormone, recomb. rat (1-34); Cysteine; SC; Rat; 2ML4; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 280-330 g); functionality of mp verified by hormone serum levels; replacement therapy (parathyroidectomy, nephrecotomy (5/6)); pumps replaced after 28 days; long-term study.

 

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying...

“A continuous infusion paradigm was utilized in both experiments to minimize any potential hemodynamic side effects from bolus NTG administration... Cha et al., Pharm Bioch and Behav 2003;74:551-557.