References Where the ALZET® Osmotic Pumps Were Used In Various Animal Models for Spinal Cord Injury Research

Q0788 Nakamura,Y., Fujita,Y., Ueno,M., Takai,T., Yamashita,T. Paired Immunoglobulin-like Receptor B Knockout Does Not Enhance Axonal Regeneration or Locomotor Recovery after Spinal Cord Injury. Journal of Biological Chemistry 2011; 286(-3-):1876-1883. >>> NEP1-40; DMSO; PBS; CSF/CNS (intrathecal); Mice; 2002; 14 days; Controls received mp w/ vehicle; animal info (C57BL/6J, 8 wks old, PIR-B-/-); NEP1-40 is a NgR antagonist peptide; 17% DMSO used; spinal cord injury.

Q0744 Kohta,M., Kohmura,E., Yamashita,T. Inhibition of TGF-beta 1 promotes functional recovery after spinal cord injury. NEUROSCIENCE RESEARCH 2009; 65(-4-):393-401. >>> Antibody, anti-TGF beta-1; CSF/CNS (intrathecal, spinal cord); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Sprague-Dawley, 200-250 g, laminectomy); silastic tubing connected to the pump; spinal cord injury.

Q0670 Nout,Y.S., Culp,E., Schmidt,M.H., Tovar,C.A., Proeschel,C., Mayer-Proeschel,M., Noble,M.D., Beattie,M.S., Bresnahan,J.C. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Experimental Neurology 2011; 227(-1-):159-171. >>> Rolipram; DMSO; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, 71 days old); stress/adverse reaction: (increased body-weight loss, increased micturition peak frequencies) see pg. 167; spinal cord injury.

Q0612 Pereira,J.E., Costa,L.M., Cabrita,A.M., Couto,P.A., Filipe,V.M., Magalhaes,L.G., Fornaro,M., Di Scipio,F., Geuna,S., Mauricio,A.C., Varejao,A.S.P. Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats. Experimental Neurology 2009; 220(-1-):71-81. >>> Methylprednisolone; Saline; IP; Rat; 2001D; 23 hours; Controls received mp w/ vehicle; animal info (Wistar, adult, female, 200 g); spinal cord injury.

Q0605 Genovese,T., Melani,A., Esposito,E., Mazzon,E., Di Paola,R., Bramanti,P., Pedata,F., Cuzzocrea,S. THE SELECTIVE ADENOSINE A2A RECEPTOR AGONIST CGS 21680 REDUCES JNK MAPK ACTIVATION IN OLIGODENDROCYTES IN INJURED SPINAL CORD. SHOCK 2009; 32(-6-):578-585. >>> CGS 21680; Saline; DMSO; SC; Mice; 2004; ; Controls received mp w/ vehicle; animal info (male, adult, CD1, 25-30 g); spinal cord injury; 10% DMSO used; CGS 21680 is an adenosine A2A receptor agonist.

Q0470 Dai,H.N., Macarthur,L., McAtee,M., Hockenbury,N., Tidwell,J.L., McHugh,B., Mansfield,K., Finn,T., Hamers,F.P.T., Bregman,B.S. Activity-Based Therapies To Promote Forelimb Use after a Cervical Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-10-):1719-1732. >>> Rolipram; Saline; DMSO; SC; Rat; 2ML1; 5, 10 days; Controls received mp w/ vehicle; animal info (adult, female, Sprague-Dawley, 6 wks old); 15% DMSO used; behavioral testing (Skilled target reaching, Gridwalk, Vertical exploration, CatWalk gait analysis).

Q0459 Beaumont,E., Whitaker,C.M., Burke,D.A., Hetman,M., Onifer,S.M. EFFECTS OF ROLIPRAM ON ADULT RAT OLIGODENDROCYTES AND FUNCTIONAL RECOVERY AFTER CONTUSIVE CERVICAL SPINAL CORD INJURY. Neuroscience 2009; 163(-4-):985-990. >>> Rolipram; DMSO; SC; Rat; 2002; ; Spinal cord injury; animal info (female, adult, Sprague Dawley, 228-267 g); multiple pumps per animal (2); stress/adverse reaction: (see pg. 966) "the data of one rat in the rolipram-treated group was removed from the study because of its morbidity".

Q0450 Marino,P., Norreel,J.C., Schachner,M., Rougon,G., Amoureux,M.C. A polysialic acid mimetic peptide promotes functional recovery in a mouse model of spinal cord injury. Experimental Neurology 2009; 219(-1-):163-174. >>> PR-21; Water; Rat; 1007D; ; Animal info (9 wks old, female, Wistar); peptides; half-life (p. 166) approximately 14 days in vitro at 37 degrees C; stability verified by ELISA; PR-21 also known as PSA-mimetic peptide; "We verified that PR-21 remained stable in the vehicle (WFI) during 14 days." pg 166; spinal cord injury.

Q0287 Furuya,T., Hashimoto,M., Koda,M., Okawa,A., Murata,A., Takahashi,K., Yamashita,T., Yamazaki,M. Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Research 2009; 1295(-;-):192-202. >>> Fasudil; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 8-10 wks old, 174-236 g); post op. care (Bacitramin); spinal cord injury.

Q0266 Byrnes,K.R., Stoica,B., Riccio,A., Pajoohesh-Ganji,A., Loane,D.J., Faden,A.I. Activation of Metabotropic Glutamate Receptor 5 Improves Recovery after Spinal Cord Injury in Rodents. Annals of Neurology 2009; 66(-1-):63-74. >>> Hydroxyphenylglycine, (RS)-2-chloro-5; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Sprague-Dawley, 275-325 g); functionality of mp verified by pump weight; spinal cord injury; 10% DMSO used; compound also known as CHPG; CHPG is a selective mGluR5 agonist.

Q0137 King,V.R., Hewazy,D., Alovskaya,A., Phillips,J.B., Brown,R.A., Priestley,J.V. THE NEUROPROTECTIVE EFFECTS OF FIBRONECTIN MATS AND FIBRONECTIN PEPTIDES FOLLOWING SPINAL CORD INJURY IN THE RAT. Neuroscience 2010; 168(-2-):523-530. >>> Fibronectin mat solution; peptide, fibronectin-derived synthetic; Saline; CSF/CNS (intrathecal); Rat; 1007D; 1, 3, 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, adult, laminectomized); silastic tubing used; spinal cord injury.

Q0009 Cirillo,G., Cavaliere,C., Bianco,M.R., De Simone,A., Colangelo,A.M., Sellitti,S., Alberghina,L., Papa,M. Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain. Cellular and Molecular Neurobiology 2010; 30(-1-):51-62. >>> Nerve growth factor, b-, recomb. rat; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (adult, male, Sprague-Dawley, 250-300 g); SCI; spinal cord injury; behavioral testing (thermal nociceptive testing, mechanical allodynia).

P9989 Qi,X.A., Du,Y., Wu,W.T., Yip,H.K. Bone morphogenetic proteins mediate cellular response and, together with Noggin, regulate astrocyte differentiation after spinal cord injury. Experimental Neurology 2010; 221(-2-):353-366. >>> Noggin, recomb. mouse; PBS; CSF/CNS (intrathecal); Mice; 1007D; 1 week; Controls received mp w/ vehicle; animal info (female, adult, C57BL/6n, 6-8 wks old); silastic tubing used for the IT cannulation.

P9954 Mountney,A., Zahner,M.R., Lorenzini,I., Oudega,M., Schramm,L.P., Schnaar,R.L. Sialidase enhances recovery from spinal cord contusion injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-25-):11561-11566. >>> Sialidase; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 12 days; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 230-250 g.); spinal cord injury.

P9890 Mehanna,A., Jakovcevski,I., Acar,A., Xiao,M.F., Loers,G., Rougon,G., Irintchev,A., Schachner,M. Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice. MOLECULAR THERAPY 2010; 18(-1-):34-43. >>> Polysialic acid, mimetic; human natural killer cell-1, mimetic, cyclic; PBS; CSF/CNS (subdural); Mice; 1002; 2 weeks; Control received mp w/ control peptide; peptides; no stress (see pg. 40); animal info (3-4 month old, female, C57BL/6J); spinal cord injury; catheter position confirmed by macrosopic examination; "no adverse effects of the pump implantation, such as infections, paralyses, or aberrant behavior, were observed." pg 40.

P9880 Wu,K.L.H., Hsu,C., Chan,J.Y.H. Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):965-977. >>> Methylisothiourea, S-; PTIO, carboxy-; Coenzyme Q10; tempol; FeTMPyP; furosemide; PJ-34; CSF, artificial; sesame oil; CSF/CNS (spinal cord); Rat; 1003D; 3 days; Controls received mp w/ vehicle; multiple pumps per animal (2); post op. care (procraine penicillin); adult, male, specific pathogen free, 200-250 g.); spinal cord injury; PE-10 catheter used; PTIO is a NO trapping agent; enzyme inhibitor PJ-34 is poly(ADP-ribose) polymerase PARP inhibitor.

P9824 Gerzanich,V., Woo,S.K., Vennekens,R., Tsymbalyuk,O., Ivanova,S., Ivanov,A., Geng,Z.H., Chen,Z., Nilius,B., Flockerzi,V., Freichel,M., Simard,J.M. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nature Medicine 2009; 15(-2-):185-191. >>> Oligonucleotide, antisense; IV (jugular); Rat; 24 hours; Controls received mp w/ sense; antisense (Trpm4); animal info (adult, female, Long Evans, 275-350 g); SCI; spinal cord injury.

P9802 Fouad,K., Ghosh,M., Vavrek,R., Tse,A.D., Pearse,D.D. Dose and Chemical Modification Considerations for Continuous Cyclic AMP Analog Delivery to the Injured CNS. Journal of Neurotrauma 2009; 26(-5-):733-740. >>> Dibutyryl cAMP; cAMP, 8-bromo; Saline; CSF/CNS (intrathecal); CSF/CNS (motor cortex); Rat; 2002; 2, 4 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (Buprenorphine); animal info (adult, female, Lewis, 180-200 g.); spinal cord injury.

P9744 Opatz,J., Kuery,P., Schiwy,N., Jaerve,A., Estrada,V., Brazda,N., Bosse,F., Mueller,H.W. SDF-1 stimulates neurite growth on inhibitory CNS myelin. MOLECULAR AND CELLULAR NEUROSCIENCE 2009; 40(-2-):293-300. >>> Stromal Cell-derived factor 1a; PBS; BSA; CSF/CNS (subarchanoid space); Rat; 2001; 1 week; Controls received mp w/vehicle; animal info (female, Wistar, 200-250 g, Spinal cord injury).

P9723 Steward,O., Zheng,B., Tessier-Lavigne,M., Hofstadter,M., Sharp,K., Yee,K.M. Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. Journal of Neuroscience 2008; 28(-27-):6836-6847. >>> NEP (1-40); DMSO; PBS; SC; Mice; 2002; ; Controls received mp w/vehicle; peptides; animal info (C57BL/6); 17% DMSO used; spinal cord injury.

P9706 Maier,I.C., Ichiyama,R.M., Courtine,G., Schnell,L., Lavrov,I., Edgerton,V.R., Schwab,M.E. Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain 2009; 132(-;-):1426-1440. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/mouse immunoglobulin G; animal info (adult, male, Sprague Dawley, 200-250 g.).

P9697 Wang,X.X., Budel,S., Baughman,K., Gould,G., Song,K.H., Strittmatter,S.M. Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth. Journal of Neurotrauma 2009; 26(-1-):81-95. >>> Ibuprofen; naproxen; PBS; SC; Rat; mice; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 11-12 wks old, 250-270 g., female, C57BL/6, 8-9 wks old, 20 g.); spinal cord injury; behavioral testing (BBB locomotor scale, Basso mouse scale).

P9602 Miyashita,T., Koda,M., Kitajo,K., Yamazaki,M., Takahashi,K., Kikuchi,A., Yamashita,T. Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):955-964. >>> Immunoglobulin G, rabbit; antibody, anti Ryk; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp/saline; animal info (Sprague Dawley, 200-250g, female); spinal cord injury; SCI.

P9578 Wong,J.K., Sharp,K., Steward,O. A straight alley version of the BBB locomotor scale. Experimental Neurology 2009; 217(-2-):417-420. >>> ; SC; Rat; 2001; ; Animal info (Fisher, female, 165-200g); spinal cord injury; empty pumps implanted; behavioral testing (open field test).

P9484 Chen,Y.H., Oatway,M.A., Weaver,L.C. Blockade of the 5-HT3 Receptor for Days Causes Sustained Relief From Mechanical Allodynia Following Spinal Cord Injury. Journal of Neuroscience Research 2009; 87(-2-):418-424. >>> Ondansetron; Saline; IV (jugular); CSF/CNS (intrathecal); Rat; 1003D; 2001; 7 days, 72 hours; Controls received mp w/ vehicle; half life (p. 423) ~45 min; animal info (male, Wistar, 250-300 g.); pumps primed; spinal cord injury; ondansetron is a 5-HT3 receptor antagonist; Zofran.

P9461 Whitaker,C.M., Beaumont,E., Wells,M.J., Magnuson,D.S.K., Hetman,M., Onifer,S.M. Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury. Neuroscience Letters 2008; 438(-2-):200-204. >>> Rolipram; DMSO; SC; Rat; 2002; 12, 24, 72 hours; Controls received mp w/ vehicle; enzyme inhibitor (phosphodiesterase 4); multiple pumps per animal (2); post op. care (Gentozen, bacitracin zinc); animal info (female, Sprague Dawley, 228-267 g., SCI).

P9447 Song,X.Y., Li,F., Zhang,F.H., Zhong,J.H., Zhou,X.F. Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury. PLoS One 2008; 3(-3-):U22-U37. >>> Brain-derived neurotrophic factor, recomb. human; CSF/CNS (sciatic nerve); Rat; 1007D; 7 days; Controls received mp w/ PBS; comparison of foot pad injections vs. mp; peptides; animal info (female, Sprague Dawley, 8-10 wks old, SCI); behavioral testing (hind limb motor function).

P9340 Christie,S.D., Comeau,B., Myers,T., Sadi,D., Purdy,M., Mendez,I. Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone. Neurosurgical Focus 2008; 25(-5-):U33-U39. >>> Methylprednisolone; Saline; IP; Rat; 7 days; Controls received equal volume injections; stress/adverse reaction: (see pg. 4) 3 of 12 animals died prematurely; animal info (male, Wistar, 250-300 g.); spinal cord injury.

P9299 Stirling,D.P., Liu,J., Plunet,W., Steeves,J.D., Tetzlaff,W. SB203580, a p38 mitogen-activated protein kinase inhibitor, fails to improve functional outcome following a moderate spinal cord injury in rat. Neuroscience 2008; 155(-1-):128-137. >>> SB203580; DMSO; streptomycin; penicillin; CSF/CNS (subarachnoid space); Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig 5); enzyme inhibitor (p38 MAP Kinase); animal info (male, Wistar, adult, SCI); behavioral testing (locomotor activity).

P9250 Dill,J., Wang,H.Y., Zhou,F.Q., Li,S.X. Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. Journal of Neuroscience 2008; 28(-36-):8914-8928. >>> Lithium Chloride; Saline, physiological; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (Glycogen synthase kinase-3); animal info (female, C57BL/6, 8-10 wks old, spinal cord injury/laminectomy); behavioral testing (BBB locomotor scale, grid walking, foot print analysis).

P9205 Nakashima,S., Arnold,S.A., Mahoney,E.T., Sithu,S.D., Zhang,Y.P., D'Souza,S.E., Shields,C.B., Hagg,T. Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. Journal of Neuroscience 2008; 28(-29-):7293-7303. >>> BpV(phen); PBS; CSF/CNS (intrathecal); Rat; 1007D; 7, 28 days; Controls received mp w/ vehicle; dose-response (fig. 2); pumps replaced every 7 days; no stress (see pg. 7297); animal info (female, Sprague Dawley, 180-200 g.); spinal cord injury; behavioral testing (grid walking, mechanical allodynia); bpV(phen) also known as potassium bisperoxo(1,10-phenanthroline) oxovanadate (V); enzyme inhibitor (protein tyrosine phosphatase).

P9186 White,R.E., Yin,F.Q., Jakeman,L.B. TGF-alpha increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice. Experimental Neurology 2008; 214(-1-):10-24. >>> Transforming growth factor-alpha; Serum, mouse; PBS; CSF/CNS (intrathecal); Mice; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; post op. care (Baytril); animal info (female, adult, C57BL/6, 10 wks old, 17-20 g.); spinal cord injury; pumps were primed in saline at 37 degree Celsius for 24 hours; pumps were weighed before and after filling; good methods; PE-50 used for catheter.

P9177 Holmberg,E., Zhang,S.X., Sarmiere,P.D., Kluge,B.R., White,J.T., Doolen,S. Statins decrease chondroitin sulfate proteoglycan expression and acute astrocyte activation in central nervous system injury. Experimental Neurology 2008; 214(-1-):78-86. >>> Simvastatin; CSF/CNS; Rat; 2004; 4 weeks; Comparison of PO gavage vs. mp; ALZET brain infusion kit used; post op. care (buprenorphine); animal info (female, Long Evans, adult, 200-22 g.); cannula placement confirmed by preparing cryosections of the brain at the lateral ventricle and verifying the presence of a cavity created by the cannula; spinal cord injury.

P9168 Bao,F., Chen,Y.H., Schneider,K.A., Weaver,L.C. An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury. Experimental Neurology 2008; 214(-2-):160-167. >>> BIO5192; Tris lactose; IV (jugular); Rat; 2001D; 1 day; Controls received mp w/ vehicle; animal info (male, female, Wistar, 200-220 g.); incorrectly stated 1003D pump has 200 ul reservoir; pumps were primed in 37 degree Celsius saline for 4 hours; BIO5192 is an alpha4beta1 inhibitor; spinal cord injury; PE10 connected to silastic medical grade tubing.

P9167 Bretzner,F., Liu,J., Currie,E., Roskams,A.J., Tetzlaff,W. Undesired effects of a combinatorial treatment for spinal cord injury - transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus. European Journal of Neuroscience 2008; 28(-9-):1795-1807. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 300-400 g.); 28 gauge cannula, silastic tubing used; spinal cord injury; wound clips used.

P9132 Liu,S., Xu,G.Y., Johnson,K.M., Echetebu,C., Ye,Z.M., Hulsebosch,C.E., McAdoo,D.J. Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: Endogenous neuroprotection. Brain Research 2008; 1231(-;-):63-74. >>> Interleukin-1, beta-, recomb.; interleukin-1, receptor antagonist; CSF, artificial; CSF/CNS (subarachnoid space); Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250 g.); spinal cord injury.

P9090 Wannier-Morino,P., Schmidlin,E., Freund,P., Belhaj-Saif,A., Bloch,J., Mir,A., Schwab,M.E., Rouiller,E.M., Wannier,T. Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A. Brain Research 2008; 1217(-;-):96-109. >>> Immunoglobulin G, monoclonal, mouse; antibody, anti-Nogo-A monoclonal, human; anitbody, anti-Nogo-A monoclonal, mouse; CSF/CNS (intrathecal); Monkey; 2ML2; ; Control animals received mp w/ control antibodies; animal info (macaque, 3-8 years old); pumps replaced every 2 weeks; polyethylene tubing used; spinal cord injury.

P8905 Yates,J.R., Heyes,M.P., Blight,A.R. 4-Chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury. Journal of Neurotrauma 2006; 23(-6-):866-881. >>> Quinolinic acid, 13C7-; Saline, physiological; IP; Guinea-pig; 1007D; 5 days; Brain tissue distribution; animal info (female, Hartley, adult, 300-480 g.); lateral compression of the spinal cord (spinal cord injury; SCI); nephrology; behavioral testing (motor testing, CTM reflex/sensory teseting).

P8894 Davies,J.E., Tang,X.F., Bournat,J.C., Davies,S.J.A. Decorin promotes plasminogen/plasmin expression within acute spinal cord injuries and by adult microglia in vitro. Journal of Neurotrauma 2006; 23(-3-4-):397-408. >>> Decorin, recomb. human; PBS; CSF/CNS (lesion); Rat; 2001; 8 days; Controls received mp w/ cannula only; peptides; animal info (female, Sprague Dawley, 200-225 g.; SCI); cannula placement confirmed post mortem.

P8873 Terayama,R., Omura,S., Fujisawa,N., Yamaai,T., Ichikawa,H., Sugimoto,T. Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience 2008; 153(-4-):1245-1255. >>> SB203580; Saline; CSF/CNS (intrathecal, cisterna magna); Rat; 2002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (p38 MAP kinase); animal info (male, Sprague Dawley, 250-300g., spinal cord injury); PE10 tubing used; pump infusion schematic pg. 1246, Fig. 1.

P8826 Kyoto,A., Hata,K., Yamashita,T. Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Research 2007; 1186(-;-):74-86. >>> Antibody, anti-RgMa; Immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Wistar, 200-250g., SCI); repulsive guidance molecule (RGMa) is a myelin-derived neurite outgrowth inhibitor.

P8820 Muellner,A., Gonzenbach,R.R., Weinmann,O., Schnell,L., Liebscher,T., Schwab,M.E. Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats. European Journal of Neuroscience 2008; 27(-2-):326-333. >>> Antibody, anti-Nogo-A monoclonal 11C7; antibody, anti-Nogo A monoclonal 7B12; Immunoglobulin G, mouse; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG; post op. care (Baytril); animal info (Lewis, 2 months old, 160-180g. SCI).

P8706 Vavrek,R., Pearse,D.D., Fouad,K. Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord transection. Journal of Neurotrauma 2007; 24(-10-):1667-1673. >>> Saline; CSF/CNS (intrathecal); Rat; 2002; 4 weeks; Animal info (female, Fischer, adult, spinal cord injury); chondroitinase ABC injected into IT catheter every other day for 4 weeks; saline mp used to keep catheters clear between injections.

P8643 Simard,J.M., Tsymbalyuk,O., Ivanov,A., Ivanova,S., Bhatta,S., Geng,Z.H., Woo,S.K., Gerzanich,V. Endothelial sulfonylurea receptor 1- regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. Journal of Clinical Investigation 2007; 117(-8-):2105-2113. >>> Glibenclamide; oligodeoxynucleotide, phosphorothioate missense; repaglinide; oligodeoxynucleotide, antisense; oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, missense; Saline; PBS; DMSO; SC; IV (jugular); CSF/CNS (parietal lobe); Rat; 2002; 1, 7, 10-14 days; Controls received mp w/ vehicle; antisense (Abcc8); ischemia (cerebral); animal info (female, Long-Evans, 275-350g, acute SCI); "We used constant infusion of a low dose of drug to achieve sustained occupancy of only high-affinity receptors." (p. 2109).

P8458 Byrnes,K.R., Stoica,B.A., Fricke,S., Di Giovanni,S., Faden,A.I. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007; 130(--):2977-2992. >>> Flavopiridol; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 275-325g); contusion spinal cord injury; 1% DMSO.

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P8134 Figueroa,J.D., Benton,R.L., Velazquez,I., Torrado,A.I., Ortiz,C.M., Hernandez,C.M., Diaz,J.J., Magnuson,D.S., Whittemore,S.R., Miranda,J.D. Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. Journal of Neuroscience Research 2006; 84(-7-):1438-1451. >>> Oligonucleotide, missense; oligonucleotide, antisense; oligonucleotide, FITC antisense; CSF/CNS (intrathecal); Rat; 2002; 1, 2, 3, 4 weeks; Controls received mp w/ missense oligonucleotide; antinsense (EphA7); brain tissue distribution; cyanoacrylate adhesive; animal info (female, Sprague-Dawley, 200-275g., SCI contusion); mp primed overnight in 37 celsius.

P8112 Ji,B., Li,M., Wu,W.T., Yick,L.W., Lee,X., Shao,Z., Wang,J., So,K.F., Mccoy,J.M., Pepinsky,R.B., Mi,S., Relton,J.K. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. MOLECULAR AND CELLULAR NEUROSCIENCE 2006; 33(-3-):311-320. >>> Immunoglobulin G1, human; LINGO-1-Fc, recomb. human; PBS; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle, or IgG1; replacement therapy (dorsal hemisection); peptides; post op. care (Buprenorphine/Buprenex, Ampicillin); animal info (female, Long Evans, 7 wk old).

P8029 Dijkstra,S., Duis,S., Pans,I.M., Lankhorst,A.J., Hamers,F.P.T., Veldman,H., Baer,P.R., Gispen,W.H., Joosten,E.A.J., Geisert,EE Jr  Experimental Neurology 2006; 202(-1-):57-66. >>> Antibody, anti-CD81; immunoglobulin, G; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Post op. care (fluid therapy, 3.0 ml saline); animal info (adult, female, Wistar, 11 weeks old, 200-240 grams); spinal cord cannulation technique outlined (p. 58); PE tubing used; pump functionality measured incorrectly; x-ray image of pump/cannulation (p. 59); behavioral study.

P7994 Vavrek,R., Girgis,J., Tetzlaff,W., Hebert,G.W., Fouad,K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 2006; 129(--):1534-1545. >>> Brain-derived neurotrophic factor; NT-3; Albumin, rat serum; CSF/CNS (left motor cortex, intrathecal, cisterna magna); Rat; 2002; 14 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; SCI (spinal cord injury); dental cement used to secure cannula; NT-3 delivered intrathecally; tissue perfusion (left motor cortex).

P7855 Koopmans,G.C., Brans,M., Gomez-Pinilla,F., Duis,S., Gispen,W.H., Torres-Aleman,I., Joosten,E.A.J., Hamers,F.P.T. Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. European Journal of Neuroscience 2006; 23(-4-):1035-1046. >>> Insulin-like growth factor I, recomb. human; insulin-like growth factor-1, anti-; Saline; SC; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 1039); peptides; animal info (female, Wistar, 11 wk. old).

P7814 Hata,K., Fujitani,M., Yasuda,Y., Doya,H., Saito,T., Yamagishi,S., Mueller,B.K., Yamashita,T. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Journal of Cell Biology 2006; 173(-1-):47-58. >>> Antibody, anti-rat RGMA; immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ rabbit IgG; animal info (female, Wistar, 200-250g., spinal cord hemisection); repulsive guidance molecule (RGM).

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P7663 Kaplin,A.I., Deshpande,D.M., Scott,E., Krishnan,C., Carmen,J.S., Shats,I., Martinez,T., Drummond,J., Dike,S., Pletnikov,M., Keswani,S.C., Moran,T.H., Pardo,C.A., Calabresi,P.A., Kerr,D.A. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. Journal of Clinical Investigation 2005; 115(-10-):2731-2741. >>> Interleukin 6, recomb. rat; PBS; BSA; CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; immunology; neurodegenerative (transverse myelitis, spinal cord injury); animal info (Sprague-Dawley, adult); SCI.

P7652 bdel-Karim,A.M., Barthlow,H.G., Bialecki,R.A., Elhilali,M.M. Effects of M274773 a neurokinin-2 receptor antagonist, on bladder function in chronically spinalized rats. Journal of Urology 2005; 174(-4-):1488-1492. >>> M274773; PEG 400; saline; SC; Rat; 2004; 1, 2 weeks; Animal info (female, Sprague-Dawley, 200-250 g); spinal cord injury (SCI).

P7563 Ikegami,T., Nakamura,M., Yamane,J., Katoh,H., Okada,S., Iwanami,A., Watanabe,K., Ishii,K., Kato,F., Fujita,H., Takahashi,T., Okano,H.J., Toyama,Y., Okano,H. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-12-):3036-3046. >>> Chondroitinase ABC; Saline, physiological; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 1 week; Controls received mp w/ heat inactivated agent; stability verified by ALZAID chemical compability test kit for 7 days; animal info (adult, female, Sprague-Dawley 230-250 g); mp primed overnight in 37 C saline; spinal cord injury.

P7559 Chan,C.C.M., Khodarahmi,K., Liu,J., Sutherland,D., Oschipok,L.W., Steeves,J.D., Tetzlaff,W. Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury. Experimental Neurology 2005; 196(-2-):352-364. >>> Y-27632; streptomycin; PBS, sterile; penicillin; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; 2, 4 days; Controls received mp w/ vehicle; functionality of mp verified by ROCK inhibitory activity in CSF; dose-response (fig. 3); stability of Y27632 verified by ROCK inhibitory activity after 13 days in mp at 37 C; enzyme inhibitor (RHO Kinase); animal info (male, Sprague-Dawley); cervical 4/5 dorsal column transection.

P7265 Ji,B.X., Li,M.W., Budel,S., Pepinsky,R.B., Walus,L., Engber,T.M., Strittmatter,S.M., Relton,J.K. Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-3-):587-594. >>> Nogo-66 receptor (27-310) ecto-Fc; immunoglobulin G, rat; PBS; CSF/CNS (intrathecal); Rat; 2004; 28 days; Controls received mp w/ vehicle rat IgG; functionality of mp verified by residual volume; stability verified by analysis of remaining mp contents; post op. care (buprenorphine/buprenex, ampicillin); spinal cord injury.

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P6803 Colpaert,F.C., Wu,W.P., Hao,J.X., Royer,I., Sautel,F., Wiesenfeld-Hallin,Z., Xu,X.J. High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury. European Journal of Pharmacology 2004; 497(-1-):29-33. >>> F13640; SC; Rat; 2ML4; 56 days; Controls received mp w/ saline; functionality of mp verified by plasma levels; long-term study; pumps replaced at day 28; 5-HT1A receptor agonist; spinal cord injury; pain.

P6801 Iannotti,C., Zhang,Y.P., Shields,C.B., Han,Y.C., Burke,D.A., Xu,X.M. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Experimental Neurology 2004; 189(-2-):317-332. >>> Glial-derived neurotrophic factor, recomb. human; glial-derived neurotrophic factor, alexa S94 dye-conjugated; Saline; CSF/CNS (intrathecal); Rat; 2004; 3 weeks; 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume and cannula patency; good methods p. 318; brain tissue distribution; spinal cord injury.

P6768 Tanaka,H., Yamashita,T., Yachi,K., Fujiwara,T., Yoshikawa,H., Tohyama,M. Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 2004; 127(-1-):155-164. >>> p21-Cip1/WAF-1, TAT fusion protein, cytoplasmic-; Y-27632; HA-1077; PBS; CSF/CNS (spinal cord, intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle or control protein; functionality of mp verified by BDA-labeled fibers; dose-response (Fig.2); enzyme inhibitor (Rho kinase); peptides.

P6629 Davies,J.E, Tang,X, Dennis,J.W., Archibald,S.J., Davies,S.J.A  European Journal of Neuroscience 2004; 19(--):1226-1242. >>> Decorin, recomb. human; PBS; CSF/CNS (spinal cord, intrathecal); Rat; 2001; 8 days; Controls received mp w/ vehicle; tissue perfusion (spinal lesion); enzyme inhibitor (tyrosine kinase); decorin is known to inhibit TGF beta and is an antagonist to EGF receptor tyrosine kinase.

P6598 Roonprapunt,C., Huang,W.C., Grill,R., Friedlander,D., Grumet,M., Chen,S.H., Schachner,M., Young,W. Soluble cell adhesion molecule L1-Fc promotes locomotor recovery in rats after spinal cord injury. Journal of Neurotrauma 2003; 20(-9-):871-882. >>> Immunoglobin, L1-Fc chimera; antibody, monoclonal, mouse IgM; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle, or mouse IgM Ab; no stress (see pg.876); stress/adverse reaction: (see pg.876) "One rat died in each group during the planned 12 week observation period."; immunology; brain tissue distribution; the chimera construct includes the extracellular domain of mouse L1 fused to the human Fc (hinge, CH2-CH3 region) and inserted into a PEE-14 vector (p. 872).

P6579 Pearse,D.D., Pereira,F.C., Marcillo,A.E., Bates,M.L., Berrocal,Y.A., Filbin,M.T., Bunge,M.B. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nature Medicine 2004; 10(-6-):610-616. >>> Rolipram; DMSO; SC; Rat; 2001; 2 weeks; Controls received mp w/ vehicle; both pumps replaced after 1 week; enzyme inhibitor (phosphodiesterase IV); multiple pumps per animal (2).

P6538 Grimpe,B., Silver,J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. Journal of Neuroscience 2004; 24(-6-):1393-1397. >>> Oligodeoxyribonucleotide, phosphorothioated; CSF/CNS (intrathecal, subarachnoid space); Mice; 1007D; 7 days; Controls received mp w/ control DNA enzyme; antisense (xylosyltransferase-1); spinal cord injury; PE-60 tubing connected to PE-10 tubing for IT delivery; DNA enzyme against xylosyltransferase-1 (XT-1).

P6504 Faulkner,J.R., Herrmann,J.E., Woo,M.J., Tansey,K.E., Doan,N.B., Sofroniew,M.V. Reactive astrocytes protect tissue and preserve function after spinal cord injury. Journal of Neuroscience 2004; 24(-9-):2143-2155. >>> Ganciclovir; Saline, sterile physiological; SC; Mice (transgenic); 7 days; Controls received mp w/ vehicle.

P6451 Seki,S., Sasaki,K., Igawa,Y., Nishizawa,O., Chancellor,M.B., De Groat,W.C., Yoshimura,N. Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. Journal of Urology 2004; 171(-1-):478-482. >>> Antibody, anti-nerve growth factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; spinal cord injury; PE-10 used for catheterization.

P6347 Kim,D.H., Jahng,T.A. Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury. Journal of Korean Medical Science 2004; 19(-1-):113-122. >>> Brain-derived neurotrophic factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2004; 6 weeks; ALZET brain infusion kit; spinal cord injury; behavorial study.

P6326 Jakeman,L.B., Wei,P., Guan,Z., Stokes,B.T. Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury. Experimental Neurology 1998; 154(--):170-184. >>> Brain-derived neurotrophic factor, recomb. human; PBS; serum, rat; CSF/CNS (intrathecal); Rat; 2002; 28 days; Controls received mp w/ vehicle, or injury only; pumps replaced at day 14; good methods p.171; post op. care (gentamycin); mp replaced at day 14 to ensure biological efficacy of BDNF at body temp..

P6234 Wu,W.P., Hao,J.X., Xu,X.J., Wiesenfeld-Hallin,Z., Koek,W., Colpaert,F.C. The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury. European Journal of Pharmacology 2003; 478(-2-3-):131-137. >>> F13640; SC; Rat; 2ML4; 56 days; Controls received mp w/ saline; functionality of mp verified by F13640 plasma levels; long-term study; pumps replaced (after 28 days).

P6182 Li,L., Xu,Q., Wu,Y., Hu,W., Gu,P., Fu,Z. Combined therapy of methylprednisolone and brain-derived neurotrophic factor promotes axonal regeneration and functional recovery after spinal cord injury in rats. Chin Med.J.(Engl.) 2003; 116(-3-):414-418. >>> Brain-derived neurotrophic factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2ML2; 1, 3, 7 days; 6 weeks; Controls received mp w/ vehicle; peptides; 6ul/hr pump used.

P6161 Marsh,D.R., Wong,S.T., Meakin,S.O., MacDonald,J.I.S., Hamilton,E.F., Weaver,L.C. Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury. Journal of Neurotrauma 2002; 19(-12-):1531-1541. >>> Immunoglobulin G, TrkA; imunoglobulin G, human; CSF, artificial; CSF/CNS (intrathecal); Rat; 2ML2; 14 days; Controls received mp w/ IgG, human; post op. care (antibiotics and analgesics); catheter was perforated with a sealed end.

P6063 Horiuchi,D., Ogata,T., Morino,T., Chuai,M., Yamamoto,H. Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hindlimb function after thoracic spinal cord injury in rat. NEUROSCIENCE RESEARCH 2003; 47(-2-):209-217. >>> SB203580; Saline; CSF/CNS (intrathecal); Rat; 1 week; Controls received mp w/ vehicle; enzyme inhibitor (p38 MAP kinase); pump infusion schematic (p. 210).

P5706 Li,S.X., Strittmatter,S.M. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. Journal of Neuroscience 2003; 23(-10-):4219-4227. >>> NEP1-40; PBS; DMSO; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; dose-response (p. 4220); comparison of acute IP injections vs. chronic SC mp; peptides; NEP1-40 is a Nogo-66 (1-40) antagonist peptide (nogo extracellular peptide [residues 1-40]); vehicle included 17% DMSO.

P5597 Fournier,A.E., Takizawa,B.T., Strittmatter,S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. Journal of Neuroscience 2003; 23(-4-):1416-1423. >>> C3 Transferase; Glutathione S-transferase; Y-27632; PBS; CSF/CNS (intrathecal); Rat; 2002; 2-3 weeks; Enzyme inhibitor (protein kinase); peptides; spinal cord injury; Y-27632 is a Rho-associated kinase (ROCK) inhibitor.

P5469 Seki,S., Sasaki,K., Fraser,M.O., Igawa,Y., Nishizawa,O., Chancellor,M.B., De Groat,W.C., Yoshimura,N. Immunoneutralization of nerve growth factor in the lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. Journal of Urology 2002; 168(-5-):2269-2274. >>> Antibody, anti-nerve growth factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 11-14 days; Controls received mp w/ vehicle; peptides.

P5467 Novikova,L.N., Novikov,L.N., Kellerth,J.O. Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats. Journal of Comparative Neurology 2002; 452(-3-):255-263. >>> Brain-derived neurotrophic factor; NT-3; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 or 5-8 weeks; Peptides.

P5268 Novikov,L.N., Novikova,L.N., Mosahebi,A., Wiberg,M., Terenghi,G., Kellerth,J.O. A novel biodegradable implant for neuronal rescue and regeneration after spinal cord injury. Biomaterials 2002/8; 23(-16-):3369-3376. >>> Brain-derived neurotrophic factor; NT-3; CSF/CNS (intrathecal); Rat; 2002; 8 weeks; Pumps replaced after 2 weeks; peptides; neurotrophin infusion w/ mp compared to biodegradable graft implants containing novel compounds; recomb. human BDNF used.

P5264 Kwon,B.K., Liu,J., Messerer,C., Kobayashi,N.R., McGraw,J., Oschipok,L., Tetzlaff,W. Survival and regeneration of rubrospinal neurons 1 year after spinal cord injury. Proc.Natl.Acad.Sci.U.S A 2002/3/5; 99(-5-):3246-3251. >>> Brain-derived neurotrophic factor; PBS; Penicillin; Streptomycin; Albumin, rat serum; CSF/CNS (parenchyma); Rat; 2001; 7 days; Controls received mp w/ vehicle; Peptides; cannula placement confirmed by histological analysis.

P5220 Kojima,A., Tator,C.H. Intrathecal administration of epidermal growth factor and fibroblast growth factor 2 promotes ependymal proliferation and functional recovery after spinal cord injury in adult rats. J Neurotrauma 2002/2; 19(-2-):223-238. >>> Epidermal growth factor; Fibroblast growth factor 2; Albumin, rat serum; Gentamicin sulfate; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 3 or 14 days; Controls received mp w/ vehicle; good methods (p. 224); lynch coil used; pump filled w/ saline; mineral oil spacer used to separate saline in pump from agent solution in catheter; agents infused separatedly or concomittantly in the same pump;.

P5218 Ikeda,O., Murakami,M., Ino,H., Yamazaki,M., Koda,M., Nakayama,C., Moriya,H. Effects of brain-derived neurotrophic factor (BDNF) on compression- induced spinal cord injury: BDNF attenuates down-regulation of superoxide dismutase expression and promotes up-regulation of myelin basic protein expression. J Neuropathol.Exp.Neurol. 2002/2; 61(-2-):142-153. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; recomb. human BDNF used.

P4984 Nesic,O., Xu,G.Y., McAdoo,D., High,K.W., Hulsebosch,C., Perez-Polo,R. IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. Journal of Neurotrauma 2001; 18(-9-):947-956. >>> Interleukin-1 receptor antagonist, recombinant mouse; CSF, artificial; CSF/CNS (spinal cord, intrathecal); rat; 1003D; ; controls received mp w/ vehicle; tissue perfusion (spinal cord T8 injury site); functionality of mp verified by ELISA IL-1 detection assay, IL-1 mRNA levels; dose response (fig 1. p. 951); peptides; PE-60 catheter tubing used.

P4940 Jones,L.L., Tuszynski,M.H. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. MICROSCOPY RESEARCH AND TECHNIQUE 2001; 54(--):317-324. >>> Dye, Evans Blue; Saline; CSF/CNS (intrathecal); Rat; 2002; 5 or 12 days; controls received mp w/ saline; functionality of mp verified by infusion of dye; pumps replaced after 5 of 12 days of infusion with fresh pumps filled with Evans Blue dye; dye infusion was for 2 days; catheter patency verified by infusion of Evans Blue dye; spinal cord injury; PE-10 was connected to PE-60 tubing..

P4677 Rabchevsky,A.G, Fugaccia,I, Turner,A.F, Blades,D.A, Mattson,M.P, Scheff,S.W  Experimental Neurology 2000; 164(--):280-291. >>> Fibroblast growth factor, basic; Saline; BSA; CSF/CNS; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Controls received mp w/ vehicle; good surgical methods (p. 281-282); peptides; ALZET brain infusion kit used; multiple pumps per animal (2) used simultaneously (one for ICV infusion and one for intrathecal infusion); schematic representation of pump infusion on p. 281; beveled PE10 tubing interfaced with PE50 tubing used for intrathecal infusion;.

P3678 Krenz,N.R., Meakin,S.O., Krassioukov,A.V., Weaver,L.C. Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury. J Neurosci 2003; 19(-17-):7405-7414. >>> Antibody, anti-nerve growth factor; Antibody, Immunoglobulin G; CSF, artificial; CSF/CNS (intrathecal); knee (articular cavity); Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by residual volume; spinal cord injury; PE-10 intrathecal catheter tubing was perforated along its length and tip was sealed; PE-100 catheter used for knee joint infusion.

P3473 Cohen,T.I., Weinberg,R.J., Blight,A.R. Intrathecal infusion of the Nitric Oxide Synthase Inhibitor N-methyl L-arginine after experimental spinal cord injury in guinea pigs. J.Neurotrauma 1996; 13(-7-):361-369. >>> L-NMMA; D-NMMA; CSF/CNS (spinal cord, intrathecal); guinea-pig; 2001; no duration posted; no comment posted.

P0501 Chvapil,M., Weinstein,P.R., Misiorowski,R.L., Telles,D., Rankin,L. Development of topical BAPN delivery system for acute spinal cord injury in dogs. J.Biomed.Mater.Res. 1984; 18(--):757-769. >>> Aminopropionitrile fumarate, B-; CSF/CNS (spinal cord, intrathecal); dog; 2ML2; no duration posted; Author states use of 2ML2 pump w/ delivery rate of 10ul/h - this is an error; delivery rate verified - possibly a 2ML1 mp was used; advantages of mp p. 768.