References on Using ALZET® Osmotic Pumps In Space
P4282 Adams,G.R., McCue,S.A., Bodell,P.W., Zeng,M., Baldwin,K.M. Effects of spaceflight and thyroid deficiency on hindlimb development. I. Muscle mass and IGF-I expression. J.Appl.Physiol. 2000; 88(--):894-903. >>> Propylthiouracil; IP; Rat (lactating); 2ML4; 16 days; Teratology; Propythiouracil was delivered to neonates via dam's milk; pilot studies showed that this resulted in similar depression in plasma T3 and T4 to direct PTU injection to neonates; Propylthiouracil is an antihyperthyroid that blocks the conversion of L-thyroxine T4 to T3; spaceflight.
P4138 Turner,R.T. Effects of short-term spaceflight and recombinant human growth hormone (rhGH) on bone growth in young rats. Aviation Space Environ Med 1995; 66(--):763-769. >>> Growth hormone, recomb. human; Phosphate; F68 detergent; SC; rat; 5 days; controls received mp w/vehicle; peptides; spaceflight.
P3604 Lorenzi,G., Gmunder,F.K., Cogoli,A. Cultivation of hamster kidney cells in a dynamic cell culture system in space (spacelab IML-1 mission). Microgravity Sci.Technol. 1993; VI/1(--):34-38. >>> NaHCO3; Glucose; HEPES; DMEM; Serum, fetal calf; Gentamicin; in vitro (cell culture); 2001; no duration posted; mp connected to cell culture chamber; "...the osmotic pump delivered sufficient fresh medium to support cell growth in the perfusion chambers." p. 37; spaceflight.
P3289 Jiang,B., Roy,R.R., Navarro,C., Edgerton,V.R. Absence of a growth hormone effect on rat soleus atrophy during a 4-day spaceflight. Am.Physiol.Soc. 1993; 74(-2-):527-531. >>> Growth hormone, recomb. human; Phosphate; F-68; SC; rat; 4 days; controls received mp w/ vehicle; functionality of mp verified by immunoassay; stability verified by HPLC; musculoskel; spaceflight.
P2163 Cronin,M., Battersby,J., Hancock,W., Schwall,T., Clark,R. Delivery of recombinant human growth hormone to rats during exposure to microgravity on NASA space shuttle discovery. Physiologist 1992; 35(-1-):S51-S52. >>> Growth hormone, recomb. human; F68 detergent; Phosphate; SC; rat; 5 days; functionality of mp verified upon removal by immunoassay; peptides; mp performed well in microgravity; spaceflight.
P3948 Gmunder,F.K., Suter,R.N., Kiess,M., Urfer,R., Nordau,C.-G., Cogoli,A. Mammalian cell cultivation in space. Adv.Space Res 1989; 9(-11-):119-127. >>> Culture media; Glucose; Fetal calf serum; HEPES buffer; Gentamycin;; in vitro (cell culture); 2001; 2002; ; diagram of dynamic cell culture system on page 123; in vitro; spaceflight.
P1382 Gmunder,F.K., Nordau,C.-G., Tschopp,A., Huber,B., Cogoli,A. Dynamic cell culture system: a new cell cultivation instrument for biological experiments in space. J.Biotechnol. 1988; 7(--):217-228. >>> Culture media, DMEM; HEPES; Serum, fetal calf; Gentamicin; Glucose; in vitro (cell culture); 2001; 7 days; Mp connected to cell culture chamber; cytotoxicity described; spaceflight.
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Researchers are saying...
“In preliminary studies using this model, we observed severe side effects with 5-FU doses beyond 25 mg/kg biweekly injections (mice developed skin ulcers, bleeding and severe diarrhea). Thus, we chose to deliver 5-FU by continuous infusion at an equivalent cumulative dose in order to minimize toxicity. Additionally, studies have demonstrated an increased efficacy of chemotherapeutic agents when administered continuously.” Stoeltzing et al. Int. J. Cancer 2003;104:496-503.
