References on the Administration of Triiodothyronine Using ALZET® Osmotic Pumps

16142 Nicolini, G., Forini, F., Kusmic, C., Pitto, L., Mariani, L., Iervasi, G. Early and short-term triiodothyronine supplementation prevents adverse post-ischemic cardiac remodeling: role of transforming growth factor-beta1 and anti-fibrotic miRNA signaling. Mol Med 2015; (--):. >>> Triiodothyronine; Saline; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Wistar, adult, 385+/- 9 g); functionality of mp verified by serum levels; cardiovascular; pumps removed after 3 days; Dose (6 ug/kg/day);.

14457 Walrand, S., Short, K.R., Heemstra, L.A., Novak, C.M., Levine, J.A., Coenen-Schimke, J.M., Nair, K.S., Nair, K.S. Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration. FASEB Journal 2014; 28(--):1499-1510. >>> Triiodothyronine; Saline; SC; Rat; Controls received mp w/ vehicle; animal info (male, Fischer 344 Brown Norway F1 hybrid, 7 and 27 months old); functionality of mp verified by blood levels; triiodothyronine aka T3;.

14377 Saba, A., Donzelli, R., Colligiani, D., Raffaelli, A., Nannipieri, M., Kusmic, C., Dos Remedios, C.G., Simonides, W.S., Iervasi, G., Zucchi, R., Saba, A. Quantification of Thyroxine and 3,5,3'-Triiodo-Thyronine in Human and Animal Hearts by a Novel Liquid Chromatography-Tandem Mass Spectrometry Method. Hormone and Metabolic Research 2014; 46(--):628-634. >>> Triiodothyronine; SC; Rat; 2002; Controls received mp w/ saline; animal info (Wistar, 280-300g); functionality of mp verified by serum levels; cardiovascular;.

14737 Forini, F., Kusmic, C., Nicolini, G., Mariani, L., Zucchi, R., Matteucci, M., Iervasi, G., Pitto, L., Iervasi, G. Triiodothyronine Prevents Cardiac Ischemia/Reperfusion Mitochondrial Impairment and Cell Loss by Regulating miR30a/p53 Axis. Endocrinology 2014; 155(--):4581-4590. >>> Triiodothyronine; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Wistar, 12-15 weeks old, 310g); ischemia (cardiac); cardiovascular;.

14577 Nagao, H., Sasaki, M., Imazu, T., Takahashi, K., Aoki, H., Minato, K., Nagao, H. Effects of triiodothyronine on turnover rate and metabolizing enzymes for thyroxine in thyroidectomized rats. LIFE SCIENCES 2014; 116(--):74-82. >>> Triiodothyronine; NaOH; saline; SC; Rat; 2ML4; Control animals received mp w/ vehicle; animal info (7 wks old, male, Sprague Dawley).

11368 Grijota-Martinez, C., Diez, D., De Escobar, G.M., Bernal, J., Morte, B. Lack of Action of Exogenously Administered T3 on the Fetal Rat Brain Despite Expression of the Monocarboxylate Transporter 8. Endocrinology 2011; 152(-4-):1713-1721. >>> Triiodothyronine ; thyroxine; Propylene glycol; SC; Rat (pregnant); 2ML2; Controls received mp w/ vehicle and sham surgery; animal info (250-300 g, female, Wistar);"(T3, T4 doses) were not corrected for increasing weight"pg 1714;"Instead of administering the hormones directly to the hypothyroid fetuses, they were given via subcutaneous infusion to pregnant dams."pg 1715.

10695 Flandin, P., Lehr, L., Asensio, C., Giacobino, J.P., Rohner-Jeanrenaud, F., Muzzin, P., Jimenez, M. Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism. Endocrine 2009; 36(-2-):246-254. >>> Triiodothyronine; NaCl; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (WT, UCP3KO, 2 mo old, female); functionality of mp verified by"increase in T3 during the treatment".

10641 Henderson, K.K., Danzi, S., Paul, J.T., Leya, G., Klein, I., Samarel, A.M. Physiological Replacement of T3 Improves Left Ventricular Function in an Animal Model of Myocardial Infarction-Induced Congestive Heart Failure. Circulation-Heart Failure 2009; 2(-3-):243-U122. >>> Triiodothyronine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (adult, male, Sprague Dawley); pumps replaced at the 4th week; long-term study; myocardial infarction.

9809 Cable, E.E., Finn, P.D., Stebbins, J.W., Hou, J.Z., Ito, B.R., van Poelje, P.D., Linemeyer, D.L., Erion, M.D. Reduction of Hepatic Steatosis in Rats and Mice After Treatment with a Liver-Targeted Thyroid Hormone Receptor Agonist. Hepatology 2009; 49(-2-):407-417. >>> MB07344; GC-1; triiodothyroacetic acid, 3,5,3'; triiodothyronine; Saline; BSA; SC; Rat; 2ML1; Controls received mp w/vehicle; animal info (male, Sprague Dawley, 300g, 10 wks old); MB07344, GC-1 are TR-beta-selective antagonists.

9724 Galton, V.A., Schneider, M.J., Clark, A.S., Germain, D.L.S. Life without Thyroxine to 3,5,3'-Triiodothyronine Conversion: Studies in Mice Devoid of the 5'-Deiodinases. Endocrinology 2009; 150(-6-):2957-2963. >>> Triiodothyronine, 3, 5, 3'-; SC; Mice; 1002; Controls received mp w/ vehicle; no stress (see pg. 2958); animal info (10 wks old, wr, D1/D2KO);"none of the animals suffered any ill effects of the implants, either generally or in the area of the pumps."(pg. 2958).

9635 Byerly, M.S., Simon, J., Lebihan-Duval, E., Duclos, M.J., Cogburn, L.A., Porter, T.E. Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 296(-4-):R1180-R1189. >>> Corticosterone; triiodothyronine; DMSO; propylene glycol; SC; Bird (chicken); 2001; Controls received mp w/ vehicle; animal info (male, 29 days old); 50% DMSO used; 50% propylene glycol used.

9257 Medina-Gomez, G., Calvo, R.M., Obregon, M.J. Thermogenic effect of triiodothyroacetic acid at low doses in rat adipose tissue without adverse side effects in the thyroid axis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1999; 67(-4-):E688-E697. >>> Triiodothyronine; triiodothyroacetic acid; NaOH; saline; BSA; SC; Rat; 2ML2; Controls received mp w/ placebo; animal info (female, Sprague Dawley).

8814 Fava, G., Ueno, Y., Glaser, S., Francis, H., Demorrow, S., Marucci, L., Marzioni, M., Benedetti, A., Venter, J., Vaculin, B., Vaculin, S., Alpini, G. Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP3/Ca2+-dependent downregulation of SRC/ERK1/2. Am J Physiol Cell Physiol 2007; 292(-4-):C1467-C1475. >>> Triiodothyronine, 2,3',5 L-; NaOH; BSA; IP; Rat; Controls received mp w/ vehicle; functionality of mp verified by serum T3 levels; animal info (male, Fisher 344, 150-175g, bile duct ligation).

8561 Short, K.R., Nygren, J., Nair, K.S. Effect of T3-induced hyperthyroidism on mitochondrial and cytoplasmic protein synthesis rates in oxidative and glycolytic tissues in rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 292(-2-):E642-E647. >>> Triiodothyronine; Saline; Na2CO3; NaOH; BSA; SC; Rat; Controls received mp w/ vehicle; functionality of mp verified by serum T3 levels; animal info (male, Sprague-Dawley, 325-350g.); endocrinology.

7803 Danzi, S., Dubon, P., Klein, I. Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation. American Journal of Physiology-Heart and Circulatory Physiology 2005; 289(-4-):H1506-H1511. >>> Triiodothyronine; NaOH; saline; SC; Rat; 1002; Controls received mp w/ vehicle or euthyroid; functionality of mp verified by serum T3 levels; replacement therapy (thyroidectomy); dose-response (fig. 1); comparison of IM injections vs. mp; half-life (pg. H1506, H1508) 7 hours in vivo in rat; cardiovascular; animal info (male, Sprague-Dawley 200 g); mp primed 24 hrs in 37 C saline;"constant infusions leads to stable serum levels by 72 h."(p. H1508;"Bolus injection was not sufficient to normalize serum T3"(p. H1510).

7370 Cettour-Rose, P., Theander-Carrillo, C., Asensio, C., Klein, M., Visser, T.J., Burger, A.G., Meier, C.A., Rohner-Jeanrenaud, F. Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. Diabetologia 2005; 48(-4-):624-633. >>> Thyroxine; leptin, human analog; triiodothyronine, reverse; Saline, isotonic; SC; Rat; 2001; Controls received mp w/ vehicle, functionality of mp verified by plasma levels, replacement therapy (hypothyroidism), enzyme inhibitor (deiodinase), peptides, multiple pumps per animal (2), agents are also known as T3 and T4.

6841 Gevers, E.F., Van Der Eerden, B.C.J., Karperien, M., Raap, A.K., Robinson, I.C.A.F., Wit, J.M. Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. Journal of Bone and Mineral Research 2002; 17(-8-):1408-1419. >>> Growth hormone, recomb. human; thyroxine; triiodothyronine; SC; Rat; Controls received teflon rods; replacement therapy (hypophysectomy).

6813 Lutz, S., Mura, R.A., Hippe, H.J., Tiefenbacher, C., Niroomand, F. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. British Journal of Pharmacology 2003; 140(-6-):1019-1026. >>> Isoproterenol; triiodothyronine; propranolol; SC; Rat; 2ML2; Controls received mp w/ saline; cardiovascular.

6142 Yoshimura, T., Yasuo, S., Watanabe, M., Iigo, M., Yamamura, T., Hirunagi, K., Ebihara, S. Light-induced hormone conversion of T(4) to T(3) regulates photoperiodic response of gonads in birds. Nature 2003; 426(-6963-):178-181. >>> Thyroxine; Iopanoic Acid; Triiodothyronine; NACL; NAOH (sodium hydroxide); HCL; CSF/CNS; Bird (quail); 2002; ALZET brain infusion kit used; placement&patency of canula verified by injecting evans blue dye.

6111 Comeau, L.A., Campana, S.E. Modifying thyroidal status in Atlantic cod by osmotic pump delivery of thyroid and antithyroid agents. TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY 2003; 132(-5-):1021-1026. >>> Triiodothyronine; iodide, potassium; methimazole; Estradiol, 17B-; testosterone; thiourea; Saline; IP; Fish (cod); 2ML1; Controls received mp w/ vehicle; functionality of mp verified by residual volume; drug plasma levels taken; potassium iodide, methimazole and thiourea are thyroid inhibitors; sex hormones were in a separate study where the ALZET pump model was not listed;"this study demonstrates the value of osmotic pumps as effective delivery vehicles for drugs in wild demersal fish."p. 1024.

6058 Levine, J.A., Nygren, J., Short, K.R., Nair, K.S. Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats. Journal of Applied Physiology 2003; 94(-1-):165-170. >>> Triiodothyronine; BSA; NaOH (sodium hydroxide); sodium bicarbonate; SC; Rat; Controls received mp w/ vehicle; pump model not stated.

5916 Short, K.R., Nygren, J., Barazzoni, R., Levine, J., Nair, K.S  Am J Physiol Endocrinol Metab 2001; 280(-5-):E761-E769. >>> Triiodothyronine; Saline; BSA; Sodium Hydroxide (NaOH); Sodium Carbonate; SC; Rat; Controls received mp w/ vehicle; 5% BSA used.

5700 Cettour-Rose, P., Burger, A.G., Meier, C.A., Visser, T.J., Rohner-Jeanrenaud, F. Central stimulatory effect of leptin on T-3 production is mediated by brown adipose tissue type II deiodinase. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2002; 283(-5-):E980-E987. >>> Leptin; thyroxine; triiodothyronine; Saline; SC; CSF/CNS; Rat; 2001; Controls received mp w/ vehicle; peptides.

5283 Haberkorn, V., Heydel, J.M., Mounie, J., Artur, Y., Goudonnet, H. Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyl transferase expression and activity in rat liver. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2002; 190(--):167-175. >>> Thyroxine; Triiodothyronine; Saline; Sodium hydroxide; SC; rat; 2002; controls received mp w/ vehicle; replacement therapy (thyroidectomy, p. 168); functionality of mp verified by thyroxine plasma levels.

4910 Chapital, A.D., Hendrick, S.R., Lloyd, L., Pieper, D. The effects of triiodothyronine augmentation on antithrombin III levels in sepsis.. American Surgeon 2001; 67(--):253-256. >>> Triiodothyronine;; Saline;; SC;; rat;; Controls received sham surgery; functionality of mp verified by T3 plasma levels by direct chemoluinescence assay; dose-response (graph p. 254); immunology;.

4877 Minami, H., Tada, K., Chowdhury, N.R., Chowdhury, J.R., Onji, M. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. Journal of Hepatology 2000; 33(--):183-188. >>> Hepatocyte growth factor; Triiodothyronine;; Saline; Heparin, sodium;; IV (portal vein);; rat;; Comparison of portal vein injections vs. mp; cancer; immunology; peptides; HGH used was recombinant human..

4811 Ojamaa, K, Kenessey, A, Klein, I  Endocrinology 2000; 141(-6-):2139-2144. >>> Triiodothyronine;; SC;; rat;; Functionality of mp verified by T3 plasma levels via chemiluminescent assay; cardiovascular;.

15653 Christenson, W.R., Becker, B.D., Hoang, H.D., Wahle, B.S., Moore, K.D., Dass, P.D., Lake, S.G., Stuart, B.P., van Goethem, D.L., Sangha, G.K., Thyssen, J.H. Extrathyroidally mediated changes in circulating thyroid hormone concentrations in the male rat following administration of an experimental oxyacetamide (FOE 5043). Toxicol. Appl. Pharmacol 1995; 132(--):253-262. >>> Thyroxine; Triiodothyronine; Saline; Serum, rat; NaOH; SC; rat; 2ML4; controls received sham surgery; functionality of mp verified by serum hormone levels; replacement therapy (thyroidectomy); toxicology.

4242 Christenson, W.R., Becker, B.D., Hoang, H.D., Wahle, B.S., Moore, K.D., Dass, P.D., Lake, S.G., Stuart, B.P., van Goethem, D.L., Sangha, G.K., Thyssen, J.H. Extrathyroidally mediated changes in circulating thyroid hormone concentrations in the male rat following administration of an experimental oxyacetamide (FOE 5043). Toxicol. Appl. Pharmacol 1995; 132(--):253-262. >>> Thyroxine; Triiodothyronine; Saline; Serum, rat; NaOH; SC; rat; 2ML4; controls received sham surgery; functionality of mp verified by serum hormone levels; replacement therapy (thyroidectomy); toxicology.

15442 Schuur, A.G., Tacken, P.J., Visser, T.J., Brouwer, A. Modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Toxicol. Pharmacol 1998; 5(--):7-16. >>> Triiodothyronine, 3,3',5'-; Thyroxine; NaOH; Saline; IP; rat; 2002; controls received mp w/vehicle or no surgery; replacement therapy (thyroidectomy); toxicology.

4031 Schuur, A.G., Tacken, P.J., Visser, T.J., Brouwer, A. Modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Toxicol. Pharmacol 1998; 5(--):7-16. >>> Triiodothyronine, 3,3',5'-; Thyroxine; NaOH; Saline; IP; rat; 2002; controls received mp w/vehicle or no surgery; replacement therapy (thyroidectomy); toxicology.

5956 Schuur, A.G., Boekhorst, F.M., Brouwer, A., Visser, T.J. Extrathyroidal effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats. Endocrinology 1997; 138(-9-):3727-3734. >>> Thyroxine; Triiodothyronine; NaOH; saline; IP; Rat; 2002; Triiodothyronine (T3)&thyroxine (T4) were dissolved in 0.1M NaOH&0.9% NaCL.

3246 Nguyen, T.T., DiStefano III, J.D., Yamada, H., Yen, Y.-M. Steady state organ distribution and metabolism of thyroxine and 3,5,3'-triiodothyronine in intestines, liver, kidneys, blood, and residual carcass of the rat in vivo. Endocrinology 1993; 133(-6-):2973-2983. >>> Triiodothyronine; Thyroxine; 125I tracer; Radio-isotopes; Albumin, bovine serum; SC; rat; 2001; functionality of mp verified in pilot studies.

3205 Wilcox, H.G., Frank, R.A., Heimberg, M. Effects of thyroid status and fasting on hepatic metabolism of apolipoprotein A-1. J. Lipid Res 1991; 32(--):395-405. >>> Triiodothyronine; Thyroxine, l-; Butanol, n-; Propylene glycol; IP; rat; 2001; 2002; controls received no treatment or mp with vehicle; functionality of mp verified by plasma levels; replacement therapy (thyroparathyroidectomy); comparison of SC T3 injections vs. mp.

3196 Wu, S.-Y., Huang, W.-S., Chopra, I.J., Jordan, M., Alvarez, D., Santini, F. Sulfation pathway of thyroid hormone metabolism in selenium-deficient male rats. Am. J. Physiol. (Endocrinol. Metab. ) 1995; 31(--):E572-E579. >>> Thyroxine sulfate; Triiodothyronine sulfate, 3,3',5'-; Triiodothyronine sulfate, reverse; NaOH; PBS; Serum, rat; SC; rat; 2001; controls received mp with saline; functionality of mp verified by serum levels.

3171 Yen, Y.-M., Distefano III, J.J., Yamada, H., Nguyen, T.T. Direct measurement of whole body thyroid hormone pool sizes and interconversion rates in fasted rats: hormone regulation implications. Endocrinology 1994; 134(-4-):1700-1709. >>> Thyroxine; Triiodothyronine; 125I tracer; Radio-isotopes; Albumin, bovine serum; NaOH; Sodium carbonate; SC; rat; 2001; functionality of mp verified in pilot studies; topical and im antibiotics used.

3127 Vidal, H., Geloen, A., Minaire, Y., Riou, J.-P. Effect of growth hormone deficiency on hormonal control of hepatic glycogenolysis in hypophysectomized rat. Metabolism 1993; 42(-5-):631-637. >>> Triiodothyronine; Corticotropin; NaOH; IP; rat; 2002; peptides.

3116 Freyschuss, B., Sahlin, L., Masironi, B., Eriksson, H. The hormonal regulation of the oestrogen receptor in rat liver: an interplay involving growth hormone, thyroid hormones and glucocorticoids. J. Endocrinol 1994; 142(--):285-298. >>> Growth hormone, human; Triiodothyronine, L-; Prolactin, ovine; Dexamethasone; SC; rat; controls received hypophysectomy only w/ no mp; functionality of mp verified by checking pumps after usage; replacement therapy (hypophysectomy); comparison of single sc injections of GH&T3 vs. mp; agents given alone or in combination; growth hormone via mp partly restores liver estrogen receptor concentration while same dose in 2 single injections daily has no effect.

2780 Connors, J.M.,, Huffman, L.J., Michalkiewicz, M., Chang, B.S.H., Dey, R.D., Hedge, G.A. Thyroid vascular conductance: differential effects of elevated plasma thyrotropin (TSH) induced by treatment with thioamides or TSH-releasing hormone. Endocrinology 1991; 129(-1-):117-125. >>> Triiodothyronine; Thyroxine; Thyrotropin-rel. factor; Saline; Sodium hydroxide; Serum, rat; SC; rat; controls received saline via injections or did not have drug-induced hypothyroidism; replacement therapy (propylthiouracil and methimazole-induced hypothyroidism); comparison of ip, iv&sc injections vs. mp; multiple pumps per animal (2) were used concurrently.

2765 Calvo, R., Obregon, M.J., Del Rey, F.E., De Escobar, G.M. The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status. Endocrinology 1992; 131(-1-):357-365. >>> Thyroxine; Triiodothyronine; PBS; Serum, rat; Sodium hydroxide; rat (pregnant); 2ML2; controls received mp w/ saline; functionality of mp verified by plasma levels; dose-response.

2658 Kakucska, I., Rand, W., Lechan, R.M. Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine. Endocrinology 1992; 130(-5-):2845-2850. >>> Triiodothyronine; Sodium hydroxide; Saline; Serum, rat; IP; rat; 2ML2; controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (methimazole-induced hypothyroidism).

2612 Liang, H., Morin, O., Burger, A.G. Effect of the antioxidant TK 12627 (Irganox) on monodeiodination and on the levels of messenger ribonucleic acid of 5'-deiodinase type I and spot 14. Acta Endocrinol 1993; 128(--):451-458. >>> Thyroxine; Triiodothyronine; 125I tracer; 131I tracer; Radio-isotopes; Albumin, bovine serum; Saline; Sodium hydroxide; IP; rat; 1003D; 2002; replacement therapy (MMI-perchlorate induced hypothyroidism).

2444 Elam, M.B., Wilcox, H.G., Solomon, S.S., Heimberg, M. In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver. Endocrinology 1992; 131(-6-):2717-2722. >>> Hydrocortisone; Triiodothyronine; Growth hormone; PEG; Sodium hydroxide; Saline; SC; rat; peptides.

2539 Hays, J.H., Eil, C., Smallridge, R.C. Sodium ipodate increases triiodothyronine action in vivo. J. Endocrinol. Invest 1992; 15(--):507-512. >>> Triiodothyronine, L-; Sodium hydroxide; Serum, rat; SC; rat; 2002; controls received thyroidectomy but no agent treatment; functionality of mp verified by in vitro testing; replacement therapy (thyroidectomy).

2234 Dulchavsky, S.A., Bailey, J. Triiodothyronine treatment maintains surfactant synthesis during sepsis. Surgery 1992; 112(--):475-479. >>> Triiodothyronine; Saline; SC; rat; controls received mp w/saline; functionality of mp verified seven levels.

2232 DiStefano, J.J., Morris, W.L., Nguyen, T.T., van Herle, A.J., Florsheim, W. Enterohepatic regulation and metabolism of 3,5,3'-triiodothyronine in hypothyroid rats. Endocrinology 1993; 132(-4-):1665-1670. >>> Triiodothyronine; 125I tracer; Sodium carbonate; Sodium hydroxide; Radio-isotopes; Serum, rat; SC; rat; 2001; replacement therapy (thyroidectomy).

2170 Barter, R.A., Klaassen, C.D. UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol. Appl. Pharmacol 1992; 113(--):36-42. >>> Thyroxine; Triiodothyronine; Saline; Sodium hydroxide; SC; rat; 2002; functionality of mp verified by serum levels (p. 38); replacement therapy (thyroidectomy); good methods.

1851 Wilcox, H.G., Heimberg, M. Effects of hyperthyroidism on synthesis, secretion and metabolism of the VLDL apoproteins by the perfused rat liver. Biochim. Biophys. Acta 1991; 1081(--):246-252. >>> Triiodothyronine; IP; rat; no comment posted.

1775 Katzeff, H.L. Increasing age impairs the thyroid hormone response to overfeeding. Proc. Soc. Exp. Biol. Med 1990; 194(--):198-203. >>> Thyroxine; Triiodothyronine; Albumin, bovine serum; Radio-isotopes; Saline; SC; rat; 2001; functionality of mp verified by serum hormone levels, measuring residual radioactivity.

1705 Wu, S.Y., Merryfield, M.L., Polk, D.H., Fisher, D.A. Two pathways for thyroxine 5'-monodeiodination in brown adipose tissue in fetal sheep: ontogenesis and divergent responses to hypothyroidism and 3,5,3'-triiodothyronine replacement. Endocrinology 1990; 126(-4-):1950-1958. >>> Triiodothyronine; sheep (fetus); functionality of mp verified by serum levels; replacement therapy (thyroidectomy).

1606 Hupart, K.H., DeFesi, C.R., Katz, C.P., Shapiro, L.E., Surks, M.I. Differential response to L-triiodothyronine of anterior pituitary growth hormone messenger ribonucleic acid (mRNA) and B-thyrotropin mRNA in a hypothyroid Walker 256 carcinoma-bearing rat model of nonthyroidal disease. Endocrinology 1990; 126(-1-):616-621. >>> Radio-isotopes; Triiodothyronine; 125I tracer; Sodium hydroxide; Serum, rat; SC; rat; 2001; comparison of IP injections vs. mp infusion; cancer/immunology.

1596 Comte, B., Vidal, H., Laville, M., Riou, J.-P. Influence of thyroid hormones on gluconeogenesis from glycerol in rat hepatocytes: a dose-response study. Metabolism 1990; 39(-3-):259-263. >>> Triiodothyronine; IP; rat; replacement therapy (thyroidectomy).

1587 Lin, Z.W., Wenderoth, M.P., Eisenberg, B.A. Individual rabbit cardiac myocytes have different thresholds for alpha myosin heavy chain regulation by thyroid hormone. Am. J. Anat 1989; 185(--):455-461. >>> Triiodothyronine, L-; SC; rabbit; functionality of mp verified by daily blood LT3 levels using RIA; replacement therapy (propylthiouracil diet-induced hypothyroid); various LT3 doses infused.

1467 Emerson, C.H., Lew, R., Braverman, L.E., DeVito, W.J. Serum thyrotropin concentrations are more highly correlated with serum triiodothyronine concentrations than with serum thyroxine concentrations in thyroid hormone-infused thyroidectomized rats. Endocrinology 1989; 124(--):2415-2418. >>> Thyroxine; Triiodothyronine; Serum, rat; Sodium hydroxide; Water; SC; rat; dose-response; functionality of mp verified by serum levels; replacement therapy (thyroidectomy).

1439 Katzeff, H.L., Bovbjerg, D., Mark, D.A. Exercise regulation of triiodothyronine metabolism. Am. J. Physiol 1988; 255(--):E824-E828. >>> Radio-isotopes; Triiodothyronine; 125I tracer; Albumin, bovine serum; Saline; SC; mice; 2001; dose-response; funtionality of mp verified by serum levels.

1331 Gavin, L.A., Moeller, M., McMahon, F.A., Castle, J.N., Gulli, R., Cavalieri, R.R. Carbohydrate feeding increases total body and specific tissue 3,5,3'-triiodothyronine neogenesis in the rat. Endocrinology 1988; 123(-2-):1075-1081. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Albumin, human serum; Sodium hydroxide; Water; SC; rat; 2001; dose-response (table); half-life; second and third pumps implanted at 7 days; third pump contained labelled T-4 to measure the MCR; functionality of mp verified by serum levels; pump replaced weekly; replacement therapy (thyroidectomy); stability determin.

1324 Anagnostou, A., Miller, M., Westenfelder, C., Clemons, G., Baranowski, R. Effects of triiodothyronine replacement on the anemia of chronic renal failure. Exp. Hematol 1988; 16(--):159-162. >>> Triiodothyronine; Sodium hydroxide; Serum, rat; Water; IP; rat; 2002; dose-response (table); comparison of sc injections vs. mp infusion; functionality of mp verified.

1323 Wilcox, H.G., Tso, P., Heimberg, M. Stimulation of intestinal secretion of apolipoprotein AI by triiodothyronine. Biochem. Biophys. Res. Commun 1988; 153(-2-):606-611. >>> Triiodothyronine; Butanol, n-; PEG; IP; rat; 2001; no comment posted.

1304 DiStefano, J.J., Sternlicht, M., Harris, D.R. Rat enterohepatic circulation and intestinal distribution of enterally infused thyroid hormones. Endocrinology 1988; 123(-5-):2526-2539. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Bile; Glycerol; Propanol; Propylene glycol; intestine (duodenum); rat; 2001; catheter to duodenum; dose-response (text); functionality of mp verified by plasma levels.

1269 Elam, M.B., Simkevich, C.P., Solomon, S.S., Wilcox, H.G., Heimberg, M. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology 1988; 122(-4-):1397-1402. >>> Cortisol; Growth hormone, human; Triiodothyronine; Sodium hydroxide; Saline; SC; rat; pump model not stated; male rats infused for 7 days, females for 14; agents infused separately; replacement therapy (hypophysectomy); peptides.

1223 Conners, J.M., Huffman, L.J., Hedge, G.A. Effects of thyrotropin on the vascular conductance of the thyroid gland. Endocrinology 1988; 122(-3-):921-929. >>> Thyroid-stimulating hormone, bovine; Thyrotropin-rel. factor; Thyroxine; Triiodothyronine; Sodium hydroxide; Saline; IV (jugular); SC; rat; pump model not stated; mp connected to catheter; dose-response; separate and simultaneous infusion of T3 and T4; NaOH is vehicle for TRH, T3, and T4; replacement therapy (hypophysectomy); peptides.

1173 Goldberg, J.R., Ehrmann, B., Katzeff, H.L. Altered triiodothyronine metabolism in zucker fatty rats. Endocrinology 1988; 122(-2-):689-693. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; SC; rat; 2001; no comment posted.

15383 Gavin, L.A., Cavalieri, R.R., Moeller, M., McMahon, F.A., Castle, J.N., Gulli, R. Brain lipoprotein lipase is responsive to nutritional and hormonal modulation. Metabolism 1987; 36(-10-):919-924. >>> Insulin; Triiodothyronine; SC; rat; 2001; dose-response; replacement therapy (streptozotocin induced diabetes, thyroidectomy); peptides.

1127 Gavin, L.A., Cavalieri, R.R., Moeller, M., McMahon, F.A., Castle, J.N., Gulli, R. Brain lipoprotein lipase is responsive to nutritional and hormonal modulation. Metabolism 1987; 36(-10-):919-924. >>> Insulin; Triiodothyronine; SC; rat; 2001; dose-response; replacement therapy (streptozotocin induced diabetes, thyroidectomy); peptides.

1063 Abraham, G., Falcou, R., Rozen, R., Mandenoff, A., Autissier, N., Apfelbaum, M. The effects of a constant T3 level and thermoneutrality in diet-induced hyperphagia. Horm. Metab. Res 1987; 19(--):96-100. >>> Triiodothyronine; Saline; SC; rat; 2002; controls received sham operation w/placebo mp; replacement therapy (thyroidectomy) pumps replaced at day 14 and day 28; long-term study.

1049 Lacour, B., Roullet, J.-B., Ricordel, Y., Drueke, T. Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats. Nephron 1987; 45(--):129-134. >>> Triiodothyronine; IP; rat; 2002; pumps replaced twice; some animals received contralateral nephrectomy; long-term study.

1009 DeVito, W.J., Connors, J.M., Hedge, G.A. The pituitary TSH response to TRH is inversely related to the plasma TSH concentration and directly related to the pituitary TSH content during hypothyroidism in the rat. Acta Endocrinol 1987; 114(--):27-36. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Saline; Serum, rat; SC; rat; 2002; pumps replaced after 7 days; dose-response; intact euthyroid control rats were left untreated; replacement therapy (thyroparathyroidectomy).

1002 Goumaz, M.O., Kaiser, C.A., Burger, A.G. Brain cortex reverse triiodothyronine (rT3) and triiodothyronine concentrations under steady state infusions of thyroxine and rT3. Endocrinology 1987; 120(--):1590-1596. >>> Thyroxine; Triiodothyronine, reverse; 125I tracer; Sodium hydroxide; Saline; Serum, rat; Sodium carbonate; IP; rat; 2001; pumps primed overnight in saline; T4 of low&high specific activity (SA) infused sep; T4 of low (SA) obtained by add. of unlabeled T4; replacement ther. (thyroidectomy).

862 Kaiser, C.A., Goumaz, M.O., Burger, A.G. In vivo inhibition of the 5'-deiodinase type II in brain cortex and pituitary by reverse triiodothyronine. Endocrinology 1986; 119(-2-):762-770. >>> Thyroxine; Triiodothyronine, reverse; Sodium hydroxide; Saline; Serum, hypothyroid rat; Sodium carbonate; IP; rat; 2001; controls received mp w/vehicle; dose response data; pumps primed overnight in buffer; various doses of agents infused; functionality of mp verified by labelling agent (extensive serum level data); replacement therapy (thyroidectomy).

727 Gavin, L.A., McMahon, F., Moeller, M. Modulation of adipose lipoprotein lipase by thyroid hormone and diabetes. Diabetes 1985; 34(--):1266-1271. >>> Insulin; Triiodothyronine; SC; rat; 2001; replacement therapy (thyroidectomy, streptozocin induced diabetes); peptides.

714 Olubadewo, J.O., Wilcox, H.G., Heimberg, M. Differential effects of alanine on ketogenesis and triacylglycerol formation by isolated perfused livers from euthyroid and hyperthyroid rats. Metabolism 1985; 34(-12-):1139-1145. >>> Triiodothyronine; Butanol, n-; Propylene glycol; IP; rat; control group received mp w/ vehicle; mp infusion of T3 to induce hyperthyroidism in rats.

539 Tibaldi, J.M., Sahnoun, N., Surks, M.I. Response of hepatic mitochondrial a-glycerophosphate dehydrogenase and malic enzyme to constant infusions of L-triiodothyronine in rats bearing the Walker 256 carcinoma. J. Clin. Invest 1984; 74(-3-):705-714. >>> Triiodothyronine; Sodium hydroxide; Serum, rat; SC; rat; 1.2 and 4.5 ug T3/100g body weight/day; dose-response data; cancer.

448 Glass, A.R., Vigersky, R.A., Rajatanavin, R., Pardridge, W., Smallridge, R.C., Wartofsky, L., Burman, K.D. Low serum thyroxine and high serum triiodothyronine in nephrotic rats: etiology and implications for bioavailability of protein-bound hormone. Endocrinology 1984; 114(-5-):1745-1753. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Serum, rat; SC; rat; 2002; replacement therapy (thyroidectomy).

436 Klein, A.H., Reviczky, A., Padbury, J.F. Thyroid hormones augment catecholamine-stimulated brown adipose tissue thermogenesis in the ovine fetus. Endocrinology 1984; 114(-4-):1065-1069. >>> Triiodothyronine; SC; sheep (fetus); replacement therapy (thyroidectomy); 25 ug/h and 50 ug/h infusions of T3.

392 Cavalieri, R.R., Castle, J.N., McMahon, F.A. Effects of dexamethasone on kinetics and distribution of triiodothyronine in the rat. Endocrinology 1984; 114(-1-):215-221. >>> Dexamethasone; Radio-isotopes; Thyroxine, l-; Triiodothyronine; 125I tracer; Albumin, human serum; Sodium hydroxide; Saline; IP; SC; rat; 2001; 2002; comparison of agents effects; replacement therapy (thyroidectomy); no stress - see p. 220; T3 and T4 used w/ and w/o 125I tracer; T4 used in 2002 pump sc, T3 in 2001 sc, Dex. in 2001 ip or sc; 3 pumps/animal.

367 Ballard, P.L., Klein, A.H., Fisher, D.A. Thyroid hormones and plasma corticosteroid binding globulin capacity in fetal and newborn lambs. Endocrinology 1983; 113(-4-):1197-1200. >>> Triiodothyronine; sheep (fetus); sheep (lamb); replacement therapy (thyroidectomy); doses of T3 were 8 ug/h, 25 ug/h, 50 ug/h.

355 Klein, A.H., Reviczky, A., Padbury, J.F., Fisher, D.A. Effect of changes in thyroid status on tissue respiration in fetal and newborn sheep. Am. J. Physiol 1983; 244(-6-):E603-E606. >>> Triiodothyronine; SC; sheep (fetus); sheep (lamb); replacement therapy (thyroidectomy).

350 Brown, J.G., Millward, D.J. Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment. Biochim. Biophys. Acta 1983; 757(--):182-190. >>> Triiodothyronine, 3,5,3'-; PEG 300; Water; IP; rat; 2001; replacement therapy (thyroidectomy).

214 Senga, O., Pittman, C.S., Lindsay, R.H., Chambers Jr, J.B., Hill Jr, J.B. Comparison of peripheral thyroid hormone metabolism in normal rats and in rats receiving prolonged glucagon infusion. Endocrinology 1982; 110(-6-):2011-2017. >>> Glucagon; Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Sodium hydroxide; Saline; IP; IV (jugular); rat; glucagon ip simultaneous infusion w/T3&T4 in vehicles iv; 2 pumps/animal.

213 Luciani, L., Michel, O., Jorgensen, E.C., Michel, R. Metabolic effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) in constant infusion by osmotic minipump to hypothyroid rat. C. R. Acad. Sc. Paris (French, English abstract) 1982; 294(-3-):361-364. >>> Triiodothyronine analog (DIMIT); Thyroxine; Triiodothyronine; SC; rat; comparison of daily sc injection vs. infusion; organ replacement therapy (thyroidectomy).

135 El-Zaheri, M.M., Vagenakis, A.G., Hinerfeld, L., Emerson, C.H., Braverman, L.E. Maternal thyroid function is the major determinant of amniotic fluid 3,3',5'-triiodothyronine in the rat. J. Clin. Invest 1981; 67(--):1126-1133. >>> Triiodothyronine, 3,3',5'-; Thyroxine; SC; rat; 2 days T4, 5 days rT3; comparison of injections vs. infusion.

130 Connors, J.M., Hedge, G.A. Effect of continuous thyroxine administration on thyrotropin secretion in thyroidectomized rats. Endocrinology 1981; 108(-6-):2098-2102. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Propanediol, 1,2-; Serum, rat; SC; rat; organ replacement therapy (thyroidectomy).

 

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying...

“CsA and RAD were administered by ALZET minipumps, which we prefer because of the well-defined drug exposure. It avoids the daily peaks and troughs of oral drug administration, which in many animal studies are not well defined.” Matsumoto et al., Trasplantation 2003;76:166-1170.