References on the Administration of Thyroxine Using ALZET® Osmotic Pumps

11878 Baysal, A., Uysal, T., Ozdamar, S., Kurt, B., Kurt, G., Gunhan, O. Comparisons of the effects of systemic administration of L-thyroxine and doxycycline on orthodontically induced root resorption in rats. European Journal of Orthodontics 2010; 32(-5-):496-504. >>> Thyroxine, L-; doxycycline; SC; Rat; 1002; Controls received mp w/ physiological serum; animal info (Wistar, male, 50-60 days old, 132 g);.

11368 Grijota-Martinez, C., Diez, D., De Escobar, G.M., Bernal, J., Morte, B. Lack of Action of Exogenously Administered T3 on the Fetal Rat Brain Despite Expression of the Monocarboxylate Transporter 8. Endocrinology 2011; 152(-4-):1713-1721. >>> Triiodothyronine ; thyroxine; Propylene glycol; SC; Rat (pregnant); 2ML2; Controls received mp w/ vehicle and sham surgery; animal info (250-300 g, female, Wistar);"(T3, T4 doses) were not corrected for increasing weight"pg 1714;"Instead of administering the hormones directly to the hypothyroid fetuses, they were given via subcutaneous infusion to pregnant dams."pg 1715.

10683 Klieverik, L.P., Coomans, C.P., Endert, E., Sauerwein, H.P., Havekes, L.M., Voshol, P.J., Rensen, P.C.N., Romijn, J.A., Kalsbeek, A., Fliers, E. Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo. Endocrinology 2009; 150(-12-):5639-5648. >>> Thyroxine; NaOH; propylene glycol; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Wistar, 320-360 g); endocrinology.

10384 Zhang, L., Medina, M.P., Hernandez, V.S., Estrada, F.S., Vega-Gonzalez, A. VASOPRESSINERGIC NETWORK ABNORMALITIES POTENTIATE CONDITIONED ANXIOUS STATE OF RATS SUBJECTED TO MATERNAL HYPERTHYROIDISM. Neuroscience 2010; 168(-2-):416-428. >>> Thyroxine, L-; SC; Rat (pregnant); 2ML4; Controls received mp w/ vehicle; animal info (Wistar, P90).

10195 Berbel, P., Navarro, D., Auso, E., Varea, E., Rodriguez, A.E., Ballesta, J.J., Salinas, M., Flores, E., Faura, C.C., De Escobar, G.M. Role of Late Maternal Thyroid Hormones in Cerebral Cortex Development: An Experimental Model for Human Prematurity. Cerebral Cortex 2010; 20(-6-):1462-1475. >>> Parathyroid hormone, rat (1-84); calcitonin, rat; thyroxine; Acetate buffer; SC; Rat (pregnant); 2001; Teratology; peptides; animal info (Female, Wistar, 250-300 g); replacement therapy (parathyroidectomy).

8995 Klieverik, L.P., Sauerwein, H.P., Ackermans, M.T., Boelen, A., Kalsbeek, A., Fliers, E. Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-3-):E513-E520. >>> Thyroxine, L-; Propylene glycol; NaOH; SC; Rat; 2ML2; Functionality of mp verified by T4 plasma concentrations; dose-response (Fig. 1); no stress (see pg. E515); post op. care (Temgesic); animal info (male, Wistar, 325-375g.); hepatic sympathetic or parasympathetic denervation.

8093 Lu, H., Klaassen, C. Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents. Peptides 2006; 27(-4-):850-857. >>> Triiodothyromine; thyroxine, L-; Saline; NaOH; SC; Rat; 2002; Controls received mp w/ vehicle, or no treatment; replacement therapy (thyroidectomy); animal info (Sprague-Dawley, 5 wk old, male).

7370 Cettour-Rose, P., Theander-Carrillo, C., Asensio, C., Klein, M., Visser, T.J., Burger, A.G., Meier, C.A., Rohner-Jeanrenaud, F. Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. Diabetologia 2005; 48(-4-):624-633. >>> Thyroxine; leptin, human analog; triiodothyronine, reverse; Saline, isotonic; SC; Rat; 2001; Controls received mp w/ vehicle, functionality of mp verified by plasma levels, replacement therapy (hypothyroidism), enzyme inhibitor (deiodinase), peptides, multiple pumps per animal (2), agents are also known as T3 and T4.

6841 Gevers, E.F., Van Der Eerden, B.C.J., Karperien, M., Raap, A.K., Robinson, I.C.A.F., Wit, J.M. Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. Journal of Bone and Mineral Research 2002; 17(-8-):1408-1419. >>> Growth hormone, recomb. human; thyroxine; triiodothyronine; SC; Rat; Controls received teflon rods; replacement therapy (hypophysectomy).

6369 Evans, I.M., Pickard, M.R., Sinha, A.K., Leonard, A.J., Sampson, D.C., Ekins, R.P. Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain. Journal of Endocrinology 2002; 175(-3-):597-604. >>> Thyroxine; PBS; BSA; NaOH; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; functionality of mp verified by tail bleed for TH levels; replacement therapy (thyroidectomy); teratology.

6142 Yoshimura, T., Yasuo, S., Watanabe, M., Iigo, M., Yamamura, T., Hirunagi, K., Ebihara, S. Light-induced hormone conversion of T(4) to T(3) regulates photoperiodic response of gonads in birds. Nature 2003; 426(-6963-):178-181. >>> Thyroxine; Iopanoic Acid; Triiodothyronine; NACL; NAOH (sodium hydroxide); HCL; CSF/CNS; Bird (quail); 2002; ALZET brain infusion kit used; placement&patency of canula verified by injecting evans blue dye.

5700 Cettour-Rose, P., Burger, A.G., Meier, C.A., Visser, T.J., Rohner-Jeanrenaud, F. Central stimulatory effect of leptin on T-3 production is mediated by brown adipose tissue type II deiodinase. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2002; 283(-5-):E980-E987. >>> Leptin; thyroxine; triiodothyronine; Saline; SC; CSF/CNS; Rat; 2001; Controls received mp w/ vehicle; peptides.

5283 Haberkorn, V., Heydel, J.M., Mounie, J., Artur, Y., Goudonnet, H. Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyl transferase expression and activity in rat liver. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2002; 190(--):167-175. >>> Thyroxine; Triiodothyronine; Saline; Sodium hydroxide; SC; rat; 2002; controls received mp w/ vehicle; replacement therapy (thyroidectomy, p. 168); functionality of mp verified by thyroxine plasma levels.

5271 Kim, I.S., Ariyaratne, H.B., Mendis-Handagama, S.M. Changes in the testis interstitium of Brown Norway rats with aging and effects of luteinizing and thyroid hormones on the aged testes in enhancing the steroidogenic potential. Biol Reprod 2002; 66(--):1359-1366. >>> Luteinizing hormone; Thyroxine; Saline; SC; rat; 2ML4; controls received mp w/ saline; functionality of mp verified by residual volume and plasma levels of LH&T4 via radioimmunoassay; dose-response (table, p. 1364); multiple pumps per animal (1-2): one for T4 and one for LH.

5230 Kobori, H., Ichihara, A., Miyashita, Y, Hayashi, M, Saruta, T. Local Renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. Journal of Endocrinology 1999; 160(--):43-47. >>> Angiotensin II; Thyroxine; Saline; SC; rat; 2004; controls received mp w/ vehicle; cardiovascular; peptides; one group received Ang II and T4 in same pump; functionality of mp verified by plasma Ang II levels.

15653 Christenson, W.R., Becker, B.D., Hoang, H.D., Wahle, B.S., Moore, K.D., Dass, P.D., Lake, S.G., Stuart, B.P., van Goethem, D.L., Sangha, G.K., Thyssen, J.H. Extrathyroidally mediated changes in circulating thyroid hormone concentrations in the male rat following administration of an experimental oxyacetamide (FOE 5043). Toxicol. Appl. Pharmacol 1995; 132(--):253-262. >>> Thyroxine; Triiodothyronine; Saline; Serum, rat; NaOH; SC; rat; 2ML4; controls received sham surgery; functionality of mp verified by serum hormone levels; replacement therapy (thyroidectomy); toxicology.

4242 Christenson, W.R., Becker, B.D., Hoang, H.D., Wahle, B.S., Moore, K.D., Dass, P.D., Lake, S.G., Stuart, B.P., van Goethem, D.L., Sangha, G.K., Thyssen, J.H. Extrathyroidally mediated changes in circulating thyroid hormone concentrations in the male rat following administration of an experimental oxyacetamide (FOE 5043). Toxicol. Appl. Pharmacol 1995; 132(--):253-262. >>> Thyroxine; Triiodothyronine; Saline; Serum, rat; NaOH; SC; rat; 2ML4; controls received sham surgery; functionality of mp verified by serum hormone levels; replacement therapy (thyroidectomy); toxicology.

15469 Pampori, N.A., Shapiro, B.H. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol. Pharmacol 1996; 50(--):1148-1156. >>> Growth hormone, rat; Thyroxine; SC; IP; rat; functionality of mp verified by residual volume; replacement therapy (hypophysectomy); peptides; multiple pumps per animal (2) (1 with each agent).

4058 Pampori, N.A., Shapiro, B.H. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol. Pharmacol 1996; 50(--):1148-1156. >>> Growth hormone, rat; Thyroxine; SC; IP; rat; functionality of mp verified by residual volume; replacement therapy (hypophysectomy); peptides; multiple pumps per animal (2) (1 with each agent).

15442 Schuur, A.G., Tacken, P.J., Visser, T.J., Brouwer, A. Modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Toxicol. Pharmacol 1998; 5(--):7-16. >>> Triiodothyronine, 3,3',5'-; Thyroxine; NaOH; Saline; IP; rat; 2002; controls received mp w/vehicle or no surgery; replacement therapy (thyroidectomy); toxicology.

4031 Schuur, A.G., Tacken, P.J., Visser, T.J., Brouwer, A. Modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Toxicol. Pharmacol 1998; 5(--):7-16. >>> Triiodothyronine, 3,3',5'-; Thyroxine; NaOH; Saline; IP; rat; 2002; controls received mp w/vehicle or no surgery; replacement therapy (thyroidectomy); toxicology.

3788 Rudling, M., Olivecrona, H., Eggertsen, G., Angelin, B. Regulation of rat hepatic low density lipoprotein receptors. J. Clin. Invest 1996; 97(-2-):292-299. >>> Growth hormone, recomb. human; Insulin-like growth factor I; Dexamethasone; Thyroxine, L-; rat; 2001; 2ML2; controls received sham operation; replacement therapy (hypophysectomy); agent infusion rates given in ug/h; recomb. human IGF-I used.

5956 Schuur, A.G., Boekhorst, F.M., Brouwer, A., Visser, T.J. Extrathyroidal effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats. Endocrinology 1997; 138(-9-):3727-3734. >>> Thyroxine; Triiodothyronine; NaOH; saline; IP; Rat; 2002; Triiodothyronine (T3)&thyroxine (T4) were dissolved in 0.1M NaOH&0.9% NaCL.

3246 Nguyen, T.T., DiStefano III, J.D., Yamada, H., Yen, Y.-M. Steady state organ distribution and metabolism of thyroxine and 3,5,3'-triiodothyronine in intestines, liver, kidneys, blood, and residual carcass of the rat in vivo. Endocrinology 1993; 133(-6-):2973-2983. >>> Triiodothyronine; Thyroxine; 125I tracer; Radio-isotopes; Albumin, bovine serum; SC; rat; 2001; functionality of mp verified in pilot studies.

3205 Wilcox, H.G., Frank, R.A., Heimberg, M. Effects of thyroid status and fasting on hepatic metabolism of apolipoprotein A-1. J. Lipid Res 1991; 32(--):395-405. >>> Triiodothyronine; Thyroxine, l-; Butanol, n-; Propylene glycol; IP; rat; 2001; 2002; controls received no treatment or mp with vehicle; functionality of mp verified by plasma levels; replacement therapy (thyroparathyroidectomy); comparison of SC T3 injections vs. mp.

3196 Wu, S.-Y., Huang, W.-S., Chopra, I.J., Jordan, M., Alvarez, D., Santini, F. Sulfation pathway of thyroid hormone metabolism in selenium-deficient male rats. Am. J. Physiol. (Endocrinol. Metab. ) 1995; 31(--):E572-E579. >>> Thyroxine sulfate; Triiodothyronine sulfate, 3,3',5'-; Triiodothyronine sulfate, reverse; NaOH; PBS; Serum, rat; SC; rat; 2001; controls received mp with saline; functionality of mp verified by serum levels.

3171 Yen, Y.-M., Distefano III, J.J., Yamada, H., Nguyen, T.T. Direct measurement of whole body thyroid hormone pool sizes and interconversion rates in fasted rats: hormone regulation implications. Endocrinology 1994; 134(-4-):1700-1709. >>> Thyroxine; Triiodothyronine; 125I tracer; Radio-isotopes; Albumin, bovine serum; NaOH; Sodium carbonate; SC; rat; 2001; functionality of mp verified in pilot studies; topical and im antibiotics used.

3030 Rudling, M., Norstedt, G., Olivecrona, H., Reihner, E., Gustafsson, J.-A., Angelin, B. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc. Natl. Acad. Sci. USA 1992; 89(--):6983-6987. >>> Growth hormone, human; Dexamethasone; Thyroxine, l-; SC; rat; 2001; replacement therapy (hypophysectomy); peptides; GH given solely, or GH/Dex, GH/Dex/T4, or Dex/T4.

2780 Connors, J.M.,, Huffman, L.J., Michalkiewicz, M., Chang, B.S.H., Dey, R.D., Hedge, G.A. Thyroid vascular conductance: differential effects of elevated plasma thyrotropin (TSH) induced by treatment with thioamides or TSH-releasing hormone. Endocrinology 1991; 129(-1-):117-125. >>> Triiodothyronine; Thyroxine; Thyrotropin-rel. factor; Saline; Sodium hydroxide; Serum, rat; SC; rat; controls received saline via injections or did not have drug-induced hypothyroidism; replacement therapy (propylthiouracil and methimazole-induced hypothyroidism); comparison of ip, iv&sc injections vs. mp; multiple pumps per animal (2) were used concurrently.

2775 Chapa, F., Kunnecke, B., Calvo, R., Escobar del Rey, F., Morreale de Escobar, G., Cerdan, S. Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance. Endocrinology 1995; 136(-1-):296-305. >>> Thyroxine; SC; rat; controls received mp w/ saline; replacement therapy (thyroidectomy).

2765 Calvo, R., Obregon, M.J., Del Rey, F.E., De Escobar, G.M. The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status. Endocrinology 1992; 131(-1-):357-365. >>> Thyroxine; Triiodothyronine; PBS; Serum, rat; Sodium hydroxide; rat (pregnant); 2ML2; controls received mp w/ saline; functionality of mp verified by plasma levels; dose-response.

2612 Liang, H., Morin, O., Burger, A.G. Effect of the antioxidant TK 12627 (Irganox) on monodeiodination and on the levels of messenger ribonucleic acid of 5'-deiodinase type I and spot 14. Acta Endocrinol 1993; 128(--):451-458. >>> Thyroxine; Triiodothyronine; 125I tracer; 131I tracer; Radio-isotopes; Albumin, bovine serum; Saline; Sodium hydroxide; IP; rat; 1003D; 2002; replacement therapy (MMI-perchlorate induced hypothyroidism).

2296 Katzeff, H.L., Selgrad, C. Impaired peripheral thyroid hormone metabolism in genetic obesity. Endocrinology 1993; 132(-3-):989-995. >>> Thyroxine; SC; rat; 2002; replacement therapy (thyroidectomy).

2170 Barter, R.A., Klaassen, C.D. UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol. Appl. Pharmacol 1992; 113(--):36-42. >>> Thyroxine; Triiodothyronine; Saline; Sodium hydroxide; SC; rat; 2002; functionality of mp verified by serum levels (p. 38); replacement therapy (thyroidectomy); good methods.

1835 Morreale de Escobar, G., Calvo, R., Obregon, M.J., Escobar del Rey, F. Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term. Endocrinology 1990; 126(-5-):2765-2767. >>> Thyroxine; 125I tracer; Potassium iodide; Radio-isotopes; rat (pregnant); no comment posted.

1775 Katzeff, H.L. Increasing age impairs the thyroid hormone response to overfeeding. Proc. Soc. Exp. Biol. Med 1990; 194(--):198-203. >>> Thyroxine; Triiodothyronine; Albumin, bovine serum; Radio-isotopes; Saline; SC; rat; 2001; functionality of mp verified by serum hormone levels, measuring residual radioactivity.

1467 Emerson, C.H., Lew, R., Braverman, L.E., DeVito, W.J. Serum thyrotropin concentrations are more highly correlated with serum triiodothyronine concentrations than with serum thyroxine concentrations in thyroid hormone-infused thyroidectomized rats. Endocrinology 1989; 124(--):2415-2418. >>> Thyroxine; Triiodothyronine; Serum, rat; Sodium hydroxide; Water; SC; rat; dose-response; functionality of mp verified by serum levels; replacement therapy (thyroidectomy).

1331 Gavin, L.A., Moeller, M., McMahon, F.A., Castle, J.N., Gulli, R., Cavalieri, R.R. Carbohydrate feeding increases total body and specific tissue 3,5,3'-triiodothyronine neogenesis in the rat. Endocrinology 1988; 123(-2-):1075-1081. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Albumin, human serum; Sodium hydroxide; Water; SC; rat; 2001; dose-response (table); half-life; second and third pumps implanted at 7 days; third pump contained labelled T-4 to measure the MCR; functionality of mp verified by serum levels; pump replaced weekly; replacement therapy (thyroidectomy); stability determin.

1306 Dubuis, J.M., Dayer, J.M., Siegrist-Kaiser, C.A., Burger, A.G. Human recombinant interleukin-1B decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats. Endocrinology 1988; 123(-5-):2175-2181. >>> Radio-isotopes; Thyroxine; 125I tracer; IP; rat; 2002; measured plasma clearance of T4; functionality of mp verified by serum levels; stability verified at 14 days.

1304 DiStefano, J.J., Sternlicht, M., Harris, D.R. Rat enterohepatic circulation and intestinal distribution of enterally infused thyroid hormones. Endocrinology 1988; 123(-5-):2526-2539. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Bile; Glycerol; Propanol; Propylene glycol; intestine (duodenum); rat; 2001; catheter to duodenum; dose-response (text); functionality of mp verified by plasma levels.

1262 Kaiser, C.A., Seydoux, J., Giacobino, J.-P., Girardier, L., Burger, A.G. Increased plasma clearance rate of thyroxine despite decreased 5'-monodeiodination: study with a peroxisome proliferator in the rat. Endocrinology 1988; 122(-3-):1087-1093. >>> Radio-isotopes; Thyroxine; 125I tracer; 131I tracer; IP; rat; 2001; 4 exp., only 1 used mp; nafenopin pellets administered concomitantly in food; 2 doses of agent infused with different radio-isotopes.

1240 Waggoner, P.R., Philp, N.J. Method for long term delivery of soluble agents to the chick chorioallantoic membrane. Experientia 1981; 37(-3-):321-322. >>> Thyroxine, l-; In vitro (egg); chorioallantoic membrane; Bird (chicken embryo); 2001; mp placed in small test tube filled w/ water and then sealed w/ parafilm; mp connected to catheter that bathed the chorioallantoic membrane.

1223 Conners, J.M., Huffman, L.J., Hedge, G.A. Effects of thyrotropin on the vascular conductance of the thyroid gland. Endocrinology 1988; 122(-3-):921-929. >>> Thyroid-stimulating hormone, bovine; Thyrotropin-rel. factor; Thyroxine; Triiodothyronine; Sodium hydroxide; Saline; IV (jugular); SC; rat; pump model not stated; mp connected to catheter; dose-response; separate and simultaneous infusion of T3 and T4; NaOH is vehicle for TRH, T3, and T4; replacement therapy (hypophysectomy); peptides.

1173 Goldberg, J.R., Ehrmann, B., Katzeff, H.L. Altered triiodothyronine metabolism in zucker fatty rats. Endocrinology 1988; 122(-2-):689-693. >>> Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; SC; rat; 2001; no comment posted.

1013 Smeds, S., Peter, H.J., Jortso, E., Gerber, H., Studer, H. Naturally occurring clones of cells with high intrinsic proliferation potential within the follicular epithelium of mouse thyroids. Cancer Res 1987; 47(--):1646-1651. >>> Thyroxine; 3H tracer; IP; mice; 2001; pumps replaced; replacement therapy (hemithyroidectomy); cancer.

1009 DeVito, W.J., Connors, J.M., Hedge, G.A. The pituitary TSH response to TRH is inversely related to the plasma TSH concentration and directly related to the pituitary TSH content during hypothyroidism in the rat. Acta Endocrinol 1987; 114(--):27-36. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Saline; Serum, rat; SC; rat; 2002; pumps replaced after 7 days; dose-response; intact euthyroid control rats were left untreated; replacement therapy (thyroparathyroidectomy).

1002 Goumaz, M.O., Kaiser, C.A., Burger, A.G. Brain cortex reverse triiodothyronine (rT3) and triiodothyronine concentrations under steady state infusions of thyroxine and rT3. Endocrinology 1987; 120(--):1590-1596. >>> Thyroxine; Triiodothyronine, reverse; 125I tracer; Sodium hydroxide; Saline; Serum, rat; Sodium carbonate; IP; rat; 2001; pumps primed overnight in saline; T4 of low&high specific activity (SA) infused sep; T4 of low (SA) obtained by add. of unlabeled T4; replacement ther. (thyroidectomy).

862 Kaiser, C.A., Goumaz, M.O., Burger, A.G. In vivo inhibition of the 5'-deiodinase type II in brain cortex and pituitary by reverse triiodothyronine. Endocrinology 1986; 119(-2-):762-770. >>> Thyroxine; Triiodothyronine, reverse; Sodium hydroxide; Saline; Serum, hypothyroid rat; Sodium carbonate; IP; rat; 2001; controls received mp w/vehicle; dose response data; pumps primed overnight in buffer; various doses of agents infused; functionality of mp verified by labelling agent (extensive serum level data); replacement therapy (thyroidectomy).

638 Simasko, S.M., Horita, A. Treatment of rats with the TRH analog MK-771. Neuropharmacology 1985; 24(-2-):157-165. >>> MK-771; Thyroxine; Sodium hydroxide; Saline; CSF/CNS; SC; rat; 1 week; comparison of once daily each icv&ip injec vs. mp infusion vs. icv injec every 2 hr; T4 in saline&NaOH given sc, MK-771 in saline only given by icv route; stability of MK-771 verified; comparison of agent's effects; MK-771 is a TRH analog.

559 Shenker, Y., Villareal, J.Z., Sider, R.S., Grekin, R.J. a-Melanocyte-stimulating hormone stimulation of aldosterone secretion in hypophysectomized rats. Endocrinology 1985; 116(-1-):138-141. >>> ACTH(1-24); Dexamethasone disodium phosphate; Melanocyte-stimulating hormone, a-; Thyroxine, l-; SC; rat; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

531 Jennings, A.S. Regulation of hepatic triiodothyronine production in the streptozotocin-induced diabetic rat. Am. J. Physiol 1984; 247(--):E526-E533. >>> Thyroxine; Sodium hydroxide; SC; rat; comparison of sc injec vs. mp infusion.

448 Glass, A.R., Vigersky, R.A., Rajatanavin, R., Pardridge, W., Smallridge, R.C., Wartofsky, L., Burman, K.D. Low serum thyroxine and high serum triiodothyronine in nephrotic rats: etiology and implications for bioavailability of protein-bound hormone. Endocrinology 1984; 114(-5-):1745-1753. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Serum, rat; SC; rat; 2002; replacement therapy (thyroidectomy).

392 Cavalieri, R.R., Castle, J.N., McMahon, F.A. Effects of dexamethasone on kinetics and distribution of triiodothyronine in the rat. Endocrinology 1984; 114(-1-):215-221. >>> Dexamethasone; Radio-isotopes; Thyroxine, l-; Triiodothyronine; 125I tracer; Albumin, human serum; Sodium hydroxide; Saline; IP; SC; rat; 2001; 2002; comparison of agents effects; replacement therapy (thyroidectomy); no stress - see p. 220; T3 and T4 used w/ and w/o 125I tracer; T4 used in 2002 pump sc, T3 in 2001 sc, Dex. in 2001 ip or sc; 3 pumps/animal.

358 Gavin, L.A., Moeller, M. Glucagon does not modulate the alterations in T3 metabolism consequent to dietary manipulation and diabetes. Diabetes 1983; 32(--):798-803. >>> Glucagon; Somatostatin; Thyroxine; SC; rat; 2001; separate pumps delivering glucagon and somatostatin were implanted simultaneously in same rat; peptides.

312 Taylor, S.E. Additional evidence against universal modulation of B-adrenoceptor responses by excessive thyroxine. Br. J. Pharmacol 1983; 78(--):639-644. >>> Thyroxine; DMSO; SC; guinea-pig; 2002; no comment posted.

214 Senga, O., Pittman, C.S., Lindsay, R.H., Chambers Jr, J.B., Hill Jr, J.B. Comparison of peripheral thyroid hormone metabolism in normal rats and in rats receiving prolonged glucagon infusion. Endocrinology 1982; 110(-6-):2011-2017. >>> Glucagon; Radio-isotopes; Thyroxine; Triiodothyronine; 125I tracer; Sodium hydroxide; Saline; IP; IV (jugular); rat; glucagon ip simultaneous infusion w/T3&T4 in vehicles iv; 2 pumps/animal.

213 Luciani, L., Michel, O., Jorgensen, E.C., Michel, R. Metabolic effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) in constant infusion by osmotic minipump to hypothyroid rat. C. R. Acad. Sc. Paris (French, English abstract) 1982; 294(-3-):361-364. >>> Triiodothyronine analog (DIMIT); Thyroxine; Triiodothyronine; SC; rat; comparison of daily sc injection vs. infusion; organ replacement therapy (thyroidectomy).

154 Gavin, L.A., McMahon, F.A., Moeller, M. The mechanism of impaired T3 production from T4 in diabetes. Diabetes 1981; 30(--):694-699. >>> Insulin; Thyroxine; Sodium hydroxide; SC; rat; 2001; NaOH in T4 only; peptides.

150 Gavin, L.A., McMahon, F.A., Moeller, M. Carbohydrate in contrast to protein feeding increases the hepatic content of active thyroxine-5'-deiodinase in the rat. Endocrinology 1981; 109(-2-):530-536. >>> Thyroxine; Sodium hydroxide; SC; rat; no comment posted.

135 El-Zaheri, M.M., Vagenakis, A.G., Hinerfeld, L., Emerson, C.H., Braverman, L.E. Maternal thyroid function is the major determinant of amniotic fluid 3,3',5'-triiodothyronine in the rat. J. Clin. Invest 1981; 67(--):1126-1133. >>> Triiodothyronine, 3,3',5'-; Thyroxine; SC; rat; 2 days T4, 5 days rT3; comparison of injections vs. infusion.

130 Connors, J.M., Hedge, G.A. Effect of continuous thyroxine administration on thyrotropin secretion in thyroidectomized rats. Endocrinology 1981; 108(-6-):2098-2102. >>> Thyroxine; Triiodothyronine; Sodium hydroxide; Propanediol, 1,2-; Serum, rat; SC; rat; organ replacement therapy (thyroidectomy).

108 Connors, J.M., Hedge, G.A. Feedback regulation of thyrotropin by thyroxine under physiological conditions. Am. J. Physiol 1981; 240(-3-):E308-E313. >>> Thyroxine; Sodium hydroxide; Propanediol, 1,2-; IP; SC; rat; comparison of oral admin. vs. infusion; organ replacement therapy (thyroidectomy).

51 Clot, J.-P., Bouhnik, J., Baudry, M., Michel, R. Rat thyroxine metabolism studied by osmotic minipump infusion. C. R. Acad. Sc. Paris (French, English abstract) 1980; 290(-3-):235-237. >>> Radio-isotopes; Thyroxine; 125I tracer; Saline; SC; rat; 1701; organ replacement therapy (thyroidectomy).

 

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“In order to investigate the in vivo role of MMPs, we established a rodent model of glioma progression... We chose continuous infusion using an osmotic pump as the method for delivering TIMP into the tumor. This paradigm allowed aggressive glioma development and circumvented the problem of the blood brain barrier disturbing reagent delivery following intravenous delivery.” Takahashi et al., Pharmacological Research 2002;46(2):155-163.