References on Toxicology Research Using ALZET® Osmotic Pumps

16271 Vivekanandarajah, A., Waters, K. A., Machaalani, R. Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem. Int J Dev Neurosci 2015; 47(-Pt B-):183-91. >>> Nicotine Hydrogen Tartrate; water; IP; Pig (mini); 2ML2; Controls received mp w/ vehicle; animal info (piglets); functionality of mp verified by blood and urine samples; toxicology; Dose (2 mg/kg/d); Resultant plasma level (20.3±2.5 ng/mL);.

16263 Tremblay-Franco, M., Cabaton, N. J., Canlet, C., Gautier, R., Schaeberle, C. M., Jourdan, F., Sonnenschein, C., Vinson, F., Soto, A. M., Zalko, D. Dynamic Metabolic Disruption in Rats Perinatally Exposed to Low Doses of Bisphenol-A. PLoS One 2015; 10(-10-):e0141698. >>> Bisphenol A; DMSO; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; animal info (Sexually mature virgin female SD rats (8–10 weeks); functionality of mp verified by Blood and liver levels; 50% DMSO used; toxicology; implanted on day 9 of pregnancy; Dose (0.25, 2.5, 25, or 250Ǩg/kg/day);.

16145 Nojiri, T., Hosoda, H., Zenitani, M., Tokudome, T., Kimura, T., Miura, K., Miyazato, M., Okumura, M., Kangawa, K. Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia. Cancer Chemother Pharmacol 2016; 78(-1-):191-7. >>> Atrial natriuretic peptide; Saline; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (C57BL6, 7 weeks old); toxicology; immunology; Dose (1.5 ug/kg/min);.

16143 Nojiri, T., Hosoda, H., Kimura, T., Tokudome, T., Miura, K., Takabatake, H., Miyazato, M., Okumura, M., Kangawa, K. Protective effects of ghrelin on cisplatin-induced nephrotoxicity in mice. Peptides 2016; 82(--):85-91. >>> Ghrelin; Saline; SC; Mice; 1003D; Controls received mp w/ vehicle; Controls received mp w/ vehicle; toxicology; cardiovascular; Dose 0.8 ug/kg/min;.

15975 LeBaron, M. J., Geter, D. R., Rasoulpour, R. J., Gollapudi, B. B., Thomas, J., Murray, J., Kan, H. L., Wood, A. J., Elcombe, C., Vardy, A., McEwan, J., Terry, C., Billington, R. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Toxicol Appl Pharmacol 2013; 270(-2-):164-73. >>> uridine, bromodeoxy-; PBS; SC; mice; 2001; toxicology; animal info: (C57BL/6J; wildtype, knock-out, and humanized); functionality of mp verified by BrdU immunohistochemistry ; cancer (hepatic); MoA; liver tumors; toxicity of agricultural molecule; sulfoxaflor; short-term rodent carcinogenicity study; 15 mg/mL; Industry authored (The Dow Chemical Company, Midland, MI, 48674, USA);.

15752 Luis M. Craveiro,, Oliver Weinmann,, Bernd Roschitzki,, Roman R. Gonzenbach,, Björn Zörner,, Laura Montani,, Benjamin K. Yee,, Joram Feldon,, RomanWilli,, Martin E. Schwaba,  Experimental Neurology 2013; (-250-):52-68. >>> Antibody, anti-Nogo-A 11C7; PBS; CSF/CNS (intrathecal); Rat; 2ML2; 2ML4; Controls received mp w/ control antibody or PBS; animal info (male, Long Evans, 2-3 months old, 300g); post op. care (Rimadyl 5 mg/kg injection SC, Baytril 5 mg/kg injection SC for 72 hours at 12 hour intervals); behavioral testing (locomotor activity, anxiety, open field test, elevated plus maze); toxicology;“This procedure ensured antibody delivery into the CSF at a constant flow rate for 2 or 4 weeks.” pg 53;.

15740 Nicolas J. Cabaton,, Cécile Canlet,, Perinaaz R. Wadia,, Marie Tremblay-Franco,, Roselyne Gautier,, Jérôme Molina,, Carlos Sonnenschein,, Jean-Pierre Cravedi,, Beverly S. Rubin,, Ana M. Soto,, and Daniel Zalko  Environ. Health Perspect 2013; (-121-):586-593. >>> Bisphenol A; DMSO; SC; rat; 2004; toxicology; 12 wk old, female, CD-1 mice; 50% DMSO in water; functionality of mp verified by plasma levels ; mp were used to induce perinatal exposure to BPA to study its global effect; dose: 0.025, 0.25, or 25 ug/kg/bw/day.

15274 Nicolas J. Cabaton,, Cécile Canlet,, Perinaaz R. Wadia,, Marie Tremblay-Franco,, Roselyne Gautier,, Jérôme Molina, Carlos Sonnenschein,, Jean-Pierre Cravedi,, Beverly S. Rubin,, Ana M. Soto,, Daniel Zalko1  Environ. Health Perspectives 2013; 121(-5-):586-593. >>> BPA; 50% DMSO in water; SC; rat; 2004; toxicology; 12 wk old, female, CD-1 mice; functionality of mp verified by plasma levels ; dose: .025, 0.25, or 25 ug/kg/bw/day; mp were used to induce perinatal exposure to BPA to study its global effect..

14999 Kumar, S., Palaia, T., Hall, C.E., Ragolia, L., Ragolia, L. Role of Lipocalin-type prostaglandin D(2) synthase (L-PGDS) and its metabolite, prostaglandin D(2), in preterm birth. PROSTAGLANDINS&OTHER LIPID MEDIATORS 2015; 118(--):28-33. >>> BWA868C; PGD2, 11-deoxy-11-methylene; Saline; Mice; 1004; Controls received mp w/ vehicle; animal info (L-PGDS); teratology; toxicology; BWA868C; PGD2, 11-deoxy-11-methylene are DP1 and DP2 receptor antagonists;.

14990 Kass, L., Durando, M., Altamirano, G.A., Manfroni-Ghibaudo, G.E., Luque, E.H., Munoz-de-Toro, M., Munoz-de-Toro, M. Prenatal Bisphenol A exposure delays the development of the male rat mammary gland. REPRODUCTIVE TOXICOLOGY 2015; 54(--):37-46. >>> Bisphenol A; DMSO; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (female, WistarGD9); teratology; toxicology;.

14934 Fujimura, M., Usuki, F., Fujimura, M. Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators. TOXICOLOGY AND APPLIED PHARMACOLOGY 2015; 282(--):259-266. >>> MCC-257; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 6 weeks old, 240-290g); toxicology; MCC-257 is a GM1 ganglioside analog;.

14891 Conceicao, E.P., Peixoto-Silva, N., Pinheiro, C.R., Oliveira, E., Moura, E.G., Lisboa, P.C., Lisboa, P.C. Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring. FOOD AND CHEMICAL TOXICOLOGY 2015; 78(--):52-59. >>> Nicotine; Saline; SC; Rat (lactating); 2ML2; Controls received mp w/ vehicle; animal info (female, Wistar, PN2); teratology; toxicology; dependence;.

14508 Yin, H.Z., Yu, S., Hsu, C.I., Liu, J., Acab, A., Wu, R., Tao, A.N., Chiang, B.J., Weiss, J.H., Weiss, J.H. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Experimental Neurology 2014; 261(--):1-9. >>> Propanoic acid, amino-beta-methyl; CSF/CNS (intrathecal); Rat (transgenic); 2004; Controls received mp w/ saline; animal info (male, hemizygous SOD1 G93A, 80 days old); neurodegenerative (amyotrophic lateral sclerosis ); toxicology; amino-beta-methylaminopropanoic acid aka beta-N-methylamino-L-alanine aka BMAA; BMAA is a neurotoxin; used PE5 catheter for IT cannulation;.

14504 Yaqoob, N., Evans, A., Foster, J.R., Lock, E.A., Lock, E.A. Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure. Toxicology 2014; 323(--):70-77. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; Animal info (male, F-344, 13-14 weeks old, 236-312g); functionality of mp verified by BrdU imaging; toxicology;.

14494 Yamada, T., Okuda, Y., Kushida, M., Sumida, K., Takeuchi, H., Nagahori, H., Fukuda, T., Lake, B.G., Cohen, S.M., Kawamura, S., Yamada, T. Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver. TOXICOLOGICAL SCIENCES 2014; 142(--):137-157. >>> Growth hormone, recombinant human; uridine, bromodeoxy; SC; Mice(transgenic; SCID); rat; 1002; 2ML1; Animal info (mice male, CD-1 or ICR or SCID, 10 weeks old; rat male, Wistar, 10 weeks old); toxicology;.

14483 Wu, K.C., Lu, Y.H., Peng, Y.H., Tsai, T.F., Kao, Y.H., Yang, H.T., Lin, C.J., Lin, C.J. Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice. Journal of Cerebral Blood Flow and Metabolism 2015; 35(--):37-47. >>> MPTP; Ringer's solution; CSF/CNS (striatum); Mice; Controls received mp w/ vehicle; animal info (male, Oct1/2 -/-, young and aged B6, WT FVB); ALZET brain infusion kit used; toxicology;.

14428 Tamura, K., Togo, Y., Kaihara, S., Hussain, A., Takahashi, K., Bessho, K., Takahashi, K. The effect of nicotine on osteoinduction by recombinant human bone morphogenetic protein 2. International Journal of Oral and Maxillofacial Surgery 2014; 43(--):1022-1029. >>> Nicotine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 10 weeks old, 250-280g); toxicology;.

14416 Steven, S., Hausding, M., Kroeller-Schoen, S., Mader, M., Mikhed, Y., Stamm, P., Zinssius, E., Pfeffer, A., Welschof, P., Agdauletova, S., Sudowe, S., Li, H.G., Oelze, M., Schulz, E., Klein, T., Muenzel, T., Daiber, A., Daiber, A. Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic Research In Cardiology 2015; 110(--):U103-U116. >>> Linagliptin; sitagliptin; SC; Mice; Animal info (male, C57BL6); functionality of mp verified by DPP-4 activity in serum; toxicology; cardiovascular;.

14356 Queisser, N., Happ, K., Link, S., Jahn, D., Zimnol, A., Geier, A., Schupp, N., Schupp, N. Aldosterone induces fibrosis, oxidative stress and DNA damage in livers of male rats independent of blood pressure changes. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 280(--):399-407. >>> Aldosterone; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley RjHan:SD, 5-6 weeks old); toxicology; cardiovascular; bp measured using tail cuff;.

14333 O'Sullivan, M.C., Durham, T.B., Valdes, H.E., Dauer, K.L., Karney, N.J., Forrestel, A.C., Bacchi, C.J., Baker, J.F., O'Sullivan, M.C. Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities. BIOORGANIC&MEDICINAL CHEMISTRY 2015; 23(--):996-1010. >>> Compound 7; Mice; Animal info (female, Swiss-Webster); comparison of injection vs mp; toxicology;.

14730 Elsworth, J.D., Jentsch, J.D., Groman, S.M., Roth, R.H., Redmond, DE Jr, Leranth, C., Elsworth, J.D. Low Circulating Levels of Bisphenol-A Induce Cognitive Deficits and Loss of Asymmetric Spine Synapses in Dorsolateral Prefrontal Cortex and Hippocampus of Adult Male Monkeys. Journal of Comparative Neurology 2015; 523(--):1248-1257. >>> Bisphenol A, deuterium-labeled; SC; Monkey; 2ML4; Controls received mp w/ vehicle; animal info (male, St, Kitts African vervet S. sabaeus, young); functionality of mp verified by plasma levels; behavioral testing (working memory performance); toxicology;"we administered BPA from a subcutaneous minipump that ensured a constant and reliable delivery of BPA"pg 1249; pumps removed after 30 days;.

13994 Wood, C.E., Jokinen, M.P., Johnson, C.L., Olson, G.R., Hester, S., George, M., Chorley, B.N., Carswell, G., Carter, J.H., Wood, C.R., Bhat, V.S., Corton, J.C., DeAngelo, A.B., Wood, C.E. Comparative Time Course Profiles of Phthalate Stereoisomers in Mice. TOXICOLOGICAL SCIENCES 2014; 139(--):21-34. >>> Thymidine, 3H-; SC; Mice; Animal info (male, B6C3F1, 21-28 days old); toxicology; Thymidine used for imaging cells undergoing DNA replication;.

13895 Parameshwaran, K., Buabeid, M.A., Bhattacharya, S., Uthayathas, S., Kariharan, T., Dhanasekaran, M., Suppiramaniam, V. Long term alterations in synaptic physiology, expression of beta2 nicotinic receptors and ERK1/2 signaling in the hippocampus of rats with prenatal nicotine exposure. NEUROBIOLOGY OF LEARNING AND MEMORY 2013; 106(-;-):102-111. >>> Nicotine; Saline; SC; Rat (pregnant); Controls received mp w/ vehicle; animal info (female, Sprague Dawley, gestation day 3); toxicology; pumps removed after pups born;.

13842 Landsiedel, R., Ma-Hock, L., Hofmann, T., Wiemann, M., Strauss, V., Treumann, S., Wohlleben, W., Groeters, S., Wiench, K., van Ravenzwaay, B., Landsiedel, R. Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials. Particle and Fibre Toxicology 2014; 11(--):U1-U26. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; Animal info (male, Wistar, Crl:WI, 7 weeks old); toxicology;.

13839 Krautz, C., Wolk, S., Steffen, A., Knoch, K.P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H.D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 2013; 56(-7-):1596-1604. >>> Uridine, bromodeoxy-; everolimus; tacrolimus; mycophenolate mofetil; sirolimus; DMSO; IP; Mice; 1004; Controls received mp w/ BrdU only; animal info (C57BL6, 10-12 weeks old, STZ); functionality of mp verified by blood levels; 100% DMSO used; stress/adverse reaction: (see pg.1598); toxicology; diabetes;.

13760 Dowty, M.E., Jesson, M.I., Ghosh, S., Lee, J., Meyer, D.M., Krishnaswami, S., Kishore, N. Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis. Journal of Pharmacology and Experimental Therapeutics 2014; 348(-1-):165-173. >>> Tofacitinib; DMSO; PEG 300; SC; Mice; Controls received mp w/ vehicle; animal info (male, DBA/1, 10-12 weeks old); functionality of mp verified by plasma levels; pumps replaced every 19 days; 33% DMSO used; dose-response (pg. 168); toxicology; immunology; Tofacitinib is a janus kinase inhibitor;.

13756 Diaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., Turyn, D., Gonzalez, L., Gonzalez, L. GH administration patterns differently regulate epidermal growth factor signaling. Journal of Endocrinology 2014; 221(--):309-323. >>> Growth hormone, porcine; SC; Mice; 1007D; Controls received mp w/ saline; animal info (Swiss-Webster, 3-4 months old, 26-30g); functionality of mp verified by plasma levels; comparison of SC injection BID vs mp; toxicology;"The results indicate that sustained delivery systems that allow continuous GH plasma patterns would be beneficial in terms of treatment safety with regard to the actions of GH on EGFR signaling and its promitogenic activity."pg 309.

13720 Boehmerle, W., Muenzfeld, H., Springer, A., Huehnchen, P., Endres, M., Boehmerle, W. Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice. JOURNAL OF MOLECULAR MEDICINE-JMM 2014; 92(--):889-900. >>> CGP-37157; DMSO; PEG; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 9 weeks old); 50% DMSO used; 50% PEG used; no stress (see pg.894); behavioral testing (von Frey hair test; hot/cold plate test, catwalk apparatus); CGP-37157 is an inhibitor of the mitochondrial Na/Ca exchanger; toxicology;.

13557 Nojima, K., Takata, T., Masuno, H. Prolonged exposure to a low-dose of bisphenol A increases spontaneous motor activity in adult male rats. Journal of Physiological Sciences 2013; 63(-4-):311-315. >>> Bisphenol A; Sesame oil; IP; Rat; 2004; Controls received mp w/ sesame oil only; animal info (male, Sprague Dawley, 8 weeks); behavioral testing (animal movement analysis); toxicology; bisphenol A aka BPA.

13546 Morimoto, Y., Oyabu, T., Horie, M., Kambara, T., Izumi, H., Kuroda, E., Creutzenberg, O., Bellmann, B., Pohlmann, G., Schuchardt, S., Hansen, T., Ernst, H. Pulmonary toxicity of printer toner following inhalation and intratracheal instillation. INHALATION TOXICOLOGY 2013; 25(-12-):679-690Uridine, bromodeoxy;. >>> Uridine, bromodeoxy;; Rat; 2ML1; Animal info (Female, Wistar, 8 weeks old); functionality of mp verified by BrdU imaging; toxicology; immunology; pumps used to deliver BrdU for imaging purposes only.

13542 McFarland, K., Spalding, T.A., Hubbard, D., Ma, J.N., Olsson, R., Burstein, E.S. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease. ACS CHEMICAL NEUROSCIENCE 2013; 4(-11-):1430-1438. >>> Bexarotene; DMSO; saline; CSF/CNS; SC; Rat; 2004; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 225-250g); 1% DMSO used; comparison of oral gavage vs mp; dose-response (Table 1, pg.1436); neurodegenerative (Parkinson's disease); post op. care (Subcutaneous fluids 10 ml/day, soft food mashes); behavioral testing (Spontaneous locomotion, head twitch, rotorod, beam test, novel object recognition); toxicology; model 2004 (ICV); model 2ML2 (SC);.

13526 Miousse, I.R., Gomez-Acevedo, H., Sharma, N., Vantrease, J., Hennings, L., Shankar, K., Cleves, M.A., Badger, T.M., Ronis, M.J. Mammary gland morphology and gene expression signature of weanling male and female rats following exposure to exogenous estradiol. EXPERIMENTAL BIOLOGY AND MEDICINE 2013; 238(-9-):1033-1046. >>> Estradiol, 17b-; PEG; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (Sprague Dawley, 21 days old); functionality of mp verified by serum measurement; dose-response (table 1&2); toxicology;.

13463 Raju, S.V., Jackson, P.L., Courville, C.A., McNicholas, C.M., Sloane, P.A., Sabbatini, G., Tidwell, S., Tang, L.P., Liu, B., Fortenberry, J.A., Jones, C.W., Boydston, J.A., Clancy, J.P., Bowen, L.E., Accurso, F.J., Blalock, J.E., Dransfield, M.T., Rowe, S.M. Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2013; 188(-11-):1321-1330. >>> Acrolein; DMSO; SC; Mice; Controls received mp w/ vehicle; animal info (A/J); functionality of mp verified by plasma serum levels; toxicology; in vivo vs in vitro effect;.

13366 Cruzan, G., Bus, J., Hotchkiss, J., Sura, R., Moore, C., Yost, G., Banton, M., Sarang, S. Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors. Regulatory Toxicology and Pharmacology 2013; 66(-1-):24-29. >>> BrdU; Saline; SC; Mice; 2001; Animal info (8 weeks old, CD-1&C57BL6); toxicology; Used to label cells&in determination of toxicity and proliferation.

13359 Chandramohan, V., Bao, X.H., Keir, S.T., Pegram, C.N., Szafranski, S.E., Piao, H., Wikstrand, C.J., McLendon, R.E., Kuan, C.T., Pastan, I.H., Bigner, D.D. Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy. Clinical Cancer Research 2013; 19(-17-):4717-4727. >>> Immunotoxin, D2C7-(scdsFv)-PE38KDEL; PBS-HSA; CSF/CNS; Mice (NSG); Controls received mp w/ vehicle or P588-(scdsFv)-PE38KDEL; animal info (male, NOD SCID gamma, 30 g, 8-12 weeks old); cancer (gliomas); toxicology; immunology;"This method of continuous intracranial delivery will aid in achieving elevated concentrations and uniform distribution of D2C7-(scdsFv)-PE38KDEL at the tumor site, which would be expected to optimize its antitumor activity. By this method, we were able to achieve significant increase in survival at a very low dose of 1 mg of D2C7-(scdsFv)-PE38KDEL"pg.4725;.

13230 Tien, L.T., Kaizaki, A., Pang, Y., Cai, Z., Fan, L.W. Neonatal exposure to lipopolysaccharide enhances dopamine transporter protein expression and accumulation of alpha-synuclein aggregation in the substantia nigra in responses to rotenone challenge in later life. SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER 2012; 42(-;-):U213-U214. >>> Rotenone; DMSO; PEG-300; SC; 2ML4; Controls received mp w/ DMSO/PEG-300; toxicology; animal info (male Sprague-Dawley rats, pregnant); neurodegenerative (Parkinson's); minipumps used to infuse rotenone to investigate whether neonatal LPS exposure cuases long lasting changes in a-synuclein aggregation and DAT expression;.

13215 Tian, Y.F., He, C.T., Chen, Y.T., Hsieh, P.S. Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats. WORLD JOURNAL OF GASTROENTEROLOGY 2013; 19(-18-):2761-2771. >>> LPS; Saline; IV; Rat; 2004; Controls received mp w/ saline; toxicology; immunology; animal info (male, sprague-dawley, 5-6 weeks old); portal vein; mp were used to infuse LPS to study the effect of lipoic acid on suppressing steatohepatitis in portal endotoxemia;.

13164 Zhidkov, N., De Souza, R., Ghassemi, A.H., Allen, C., Piquette-Miller, M. Continuous Intraperitoneal Carboplatin Delivery for the Treatment of Late-Stage Ovarian Cancer. MOLECULAR PHARMACEUTICS 2013; 10(-9-):3315-3322. >>> Carboplatin; PBS; IP; Mice (SCID); 1002; Controls received mp w/ saline; toxicology; animal info (6-8 week old female SCID); comparison of bolus injection vs mp; cancer (ovarian).

12232 Soler-Martin, C., Riera, J., Seoane, A., Cutillas, B., Ambrosio, S., Boadas-Vaello, P., Llorens, J. The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo. NEUROTOXICOLOGY AND TERATOLOGY 2010; 32(-2-):289-294. >>> Acetone cyanohydrin; potassium cyanide; Saline, acidified; SC; Rat; 2001D; 2ML1; Controls received mp w/ vehicle; animal info (male, female, Long-Evans);"exposure was performed using osmotic pumps, with the aim of modeling the continuous exposure to acetone cyanohydrin that may result from the release of this nitrile from ingested cassava flour."; stress/adverse reaction: (see pg. 291)"Using a 24 h delivery schedule with the 2001D pumps, one animal also died before this time of exposure to 35µmol/kg/h of acetone cyanohydrin."; behavioral testing (open field); konzo; toxicology.

10454 Masunaga, S., Tano, K., Nakamura, J., Watanabe, M., Kashino, G., Takahashi, A., Tanaka, H., Suzuki, M., Ohnishi, K., Kinashi, Y., Liu, Y., Ohnishi, T., Ono, K. Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status. Journal of Radiation Research 2010; 51(-1-):27-35. >>> Uridine, bromodeoxy; hexamethylenetetramine; Saline, physiological; SC; Mice (nude); 2001D; 2001; Cancer; toxicology; animal info (6-7 weeks old, female, syngenic, Balb/Ca).

10361 Ding, D., Kanaly, C.W., Bigner, D.D., Cummings, T.J., Herndon, JE II, Pastan, I., Raghavan, R., Sampson, J.H. Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. Journal of Neuro-oncology 2010; 98(-1-):1-7. >>> MR1-1; Gadolinium-DTPA; Saline; albumin, human serum; CSF/CNS (parenchyma); Rat; 2ML2; Toxicology; cancer (glioblastoma); no stress (see pg. 4); animal info (male, Fisher 344, 3 months old); dose-response (Fig.1); skin wounds closed with wound clips; behavioral testing (stepping and placing reflex and incline ramp climbing ability); CED (Convection enhanced delivery) infusion;"All rats survived the entirety of the study without clinical or histological toxicity attributable to the study drugs."(p. 1); MR1-1 is a recomb. immunotoxin of a mAb-endotoxin frag; Plastics One cannula used; MRI; brain tissue distribution.


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What researchers are saying...

“Insofar as multiple dosing is concerned, we propose that only administration by pump (or administration more than four times a day) can provide clinical-like occupancies for haloperidol, olanzapine, and risperidone.” Kapur et al., The Journal of Pharmacology and Experimental Therapeutics 2003;305:625-631.