References on Transplantation Research Using ALZET^® Osmotic Pumps

Q0812 Tsukioka,S., Uchida,J., Tsujimoto,H., Nakagawa,F., Sugimoto,Y., Oka,T., Kiniwa,M. Oral fluoropyrimidine S-1 combined with leucovorin is a promising therapy for colorectal cancer: Evidence from a xenograft model of folate-depleted mice. Molecular Medicine Reports 2009; 2(-3-):393-398. >>> Fluorouracil, 5-; Sailne, sterile; SC; Mice; 2002; 14 days; Animal info (BALB/cA-nu/nu, 4-5 wks old); cancer (colorectal); "oral S-1/LV therapy inhibited the growth of COL-1 tumors more effectively than the infusion of 5-FU/LV when administered at doses of similar toxicity" pg 397.

Q0772 Hartman,N.W., Carpentino,J.E., LaMonica,K., Mor,D.E., Naegele,J.R., Grabel,L. CXCL12-Mediated Guidance of Migrating Embryonic Stem Cell-Derived Neural Progenitors Transplanted into the Hippocampus. PLoS One 2010; 5(-12-):U385-U397. >>> AMD3100; PBS; SC; Mice; 1004; ; Controls received mp w/ vehicle; animal info (8-10 wks old, B6.CB17-Prkdc scid/SzJ); tissue adhesive and wound clips used.

Q0715 Shibata,M.A., Morimoto,J., Shibata,E., Kurose,H., Akamatsu,K., Li,Z.L., Kusakabe,M., Ohmichi,M., Otsuki,Y. Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer. BMC CANCER 2010; 10(-;-):U1-U14. >>> Raloxifene; DMSO; ethanol; SC; Mice; 2002; 6 weeks; Animal info (female, 6 wks old, BALB/c); long-term study; pumps replaced every other week; cancer (metastatic breast cancer); stress/adverse reaction: "one animal died from an overdose of anesthesia when the osmotic mini-pumps were changed" (see pg. 7 of 14); raloxifene is a novel selective estrogen receptor modulator; chemotherapeutic.

Q0670 Nout,Y.S., Culp,E., Schmidt,M.H., Tovar,C.A., Proeschel,C., Mayer-Proeschel,M., Noble,M.D., Beattie,M.S., Bresnahan,J.C. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Experimental Neurology 2011; 227(-1-):159-171. >>> Rolipram; DMSO; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, 71 days old); stress/adverse reaction: (increased body-weight loss, increased micturition peak frequencies) see pg. 167; spinal cord injury.

Q0545 Hicks,A.U., Lappalainen,R.S., Narkilahti,S., Suuronen,R., Corbett,D., Sivenius,J., Hovatta,O., Jolkkonen,J. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery. European Journal of Neuroscience 2009; 29(-3-):562-574. >>> Cyclosporine A; PEG 400; SC; Rat; 2ML4; 2002; ; Controls received mp w/ vehicle; animal info (male, Wistar, 275-300 g, dMCAO); functionality of mp verified by residual volume; behavioral testing (Montoya's staircase test).

Q0362 Zeng,M.H., Guinet,E., Nouri-Shirazi,M. Comparative analysis of dendritic cells and anti-CD3/CD8 expanded regulatory T cells for application in transplantation. TRANSPLANT IMMUNOLOGY 2009; 22(-1-2-):82-92. >>> Ovalbumin; Mice; ; Animal info (6-16 wks old, C57BL/6, (B6. H-2b), BABL/c (Ba, H-2d), OVA-specific TCR transgenic); peptides.

Q0336 Park,H.B., Oh,K., Garmaa,N., Seo,M.W., Byoun,O.J., Lee,H.Y., Lee,D.S. CP-690550, a Janus Kinase Inhibitor, Suppresses CD4+ T-Cell-Mediated Acute Graft-Versus-Host Disease by Inhibiting the Interferon-gamma Pathway. Transplantation 2010; 90(-8-):825-835. >>> CP690550; Mice; 14 days; Animal info ((B6xbm12)F1 (H-2bxbm12)); immunology; enzyme inhibitor (janus kinase, JAK3).

Q0331 az-Garcia,C., Akhi,S.N., Wallin,A., Pellicer,A., Braennstroem,M. First report on fertility after allogeneic uterus transplantation. Acta Obstetricia et Gynecologica Scandinavica 2010; 89(-11-):1491-1494. >>> Tacrolimus; NaCl; SC; Rat; 2ML4; ; Animal info (female, dark, agouti , virgin, Lewis, 170-200 g); pumps replaced after 27 days.

Q0287 Furuya,T., Hashimoto,M., Koda,M., Okawa,A., Murata,A., Takahashi,K., Yamashita,T., Yamazaki,M. Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Research 2009; 1295(-;-):192-202. >>> Fasudil; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 8-10 wks old, 174-236 g); post op. care (Bacitramin); spinal cord injury.

Q0263 Jing,M., Shingo,T., Yasuhara,T., Kondo,A., Morimoto,T., Wang,F.F., Baba,T., Yuan,W.J., Tajiri,N., Uozumi,T., Murakami,M., Tanabe,M., Miyoshi,Y., Zhao,S.G., Date,I. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Brain Research 2009; 1295(-;-):203-217. >>> Erythropoietin, human, recomb.; Saline; albumin, rat serum; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, 190-210 g).

Q0221 Sireci,G., Barera,A., Macaluso,P., Di Sano,C., Bonanno,C.T., La Manna,M.P., Di Liberto,D., Dieli,F., Salerno,A. A continuous infusion of a minor histocompatibility antigen-immunodominant peptide induces a delay of male skin graft rejection. Immunobiology 2009; 214(-8-):703-711. >>> WI peptide; PBS; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; animal info (C57BL/6 (H-2b, Thy 1.2), Thy 1.1 C57BL6); WI peptide is WMHHNMDLI.

Q0111 Demestre,M., Herzberg,J., Holtkamp,N., Hagel,C., Reuss,D., Friedrich,R.E., Kluwe,L., Von Deimling,A., Mautner,V.F., Kurtz,A. Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model. Journal of Neuro-oncology 2010; 98(-1-):11-19. >>> Imatinib mesylate; PBS; SC; Mice (nude); 2004; 28 days; Controls received mp w/ vehicle; cancer (Plexiform neurofibromas); enzyme inhibitor (receptor tyrosine kinase); stress/adverse reaction: (see pg 13) "because of inflammation at the ALZET pump site, four mice of the treatment group had to be discontinued"; animal info (female, athymic nu/nu Balb/c); agent also known as Glivec or Gleevec.

Q0096 Xu,Y., Gong,B., Yang,Y.L., Awasthi,Y.C., Boor,P.J. Adenovirus-Mediated Overexpression of Glutathione-S-Transferase Mitigates Transplant Arteriosclerosis in Rabbit Carotid Allografts. Transplantation 2010; 89(-4-):409-416. >>> Cyclosporin; IP; Rabbit; ; Animal info (DB, NZW, 3 months old, male).

Q0089 Veeravalli,K.K., Chetty,C., Ponnala,S., Gondi,C.S., Lakka,S.S., Fassett,D., Klopfenstein,J.D., Dinh,D.H., Gujrati,M., Rao,J.S. MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice. PLoS One 2010; 5(-7-):U28-U42. >>> MMP-9; uPAR; cathepsin B; CSF/CNS; Mice; ; Pump infused at a rate of 0.2 u/hr.

Q0061 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Schut,D., Fehlings,M.G. Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord. Journal of Neuroscience 2010; 30(-5-):1657-1676. >>> Chondriotinase ABC; epidermal growth factor; fibroblast growth factor; platelet-derived growth factor; Penicillinase; saline; albumin, rat serum; CSF, artificial; gentamicin; BSA; CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (female, Wistar, 250 g.); ALZET intrathecal catheter used (0007741).

P9956 Carbajal,K.S., Schaumburg,C., Strieter,R., Kane,J., Lane,T.E. Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-24-):11068-11073. >>> AMD3100; HBSS; SC; Mice; ; Animal info (5-7 wks, C56BL/6).

P9860 Stenderup,K., Rosada,C., Worsaae,A., gnaes-Hansen,F., Steiniche,T., Hasselager,E., Iversen,L.F., Zahn,S., Woeldike,H., Lindgreen Holmberg,H., Romer,J., Kragballe,K., Clausen,J.T., Dam,T.N. Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model. British Journal of Dermatology 2009; 160(-2-):284-296. >>> Interleukin-20, recomb. human; Mice (SCID); 2002; 4 weeks; Controls received mp w/ vehicle; animal info (CB-17, 6-8 wks old).

P9821 Wideman,R.D., Gray,S.L., Covey,S.D., Webb,G.C., Kieffer,T.J. Transplantation of PC1/3-Expressing alpha-cells Improves Glucose Handling and Cold Tolerance in Leptin-resistant Mice. MOLECULAR THERAPY 2009; 17(-1-):191-198. >>> Glucagon-like peptide-2, rat; glucagon-like peptide-1, human (7-36) amide; oxytomodulin; Saline; IP; Mice; 1004; ; Controls received mp w/ vehicle; peptides; animal info (db/db, 6 wks old).

P9819 Savai,R., Langheinrich,A.C., Schermuly,R.T., Pullamsetti,S.S., Dumitrascu,R., Traupe,H., Rau,W.S., Seeger,W., Grimminger,F., Banat,A. Evaluation of Angiogenesis Using Micro-Computed Tomography in a Xenograft Mouse Model of Lung Cancer. NEOPLASIA 2009; 11(-1-):48-56. >>> Bevacizumab; IV (jugular); Mice (nude); 2002; 14 days; Controls received mp w/ distilled water; animal info (female, C57BL/6, 5-7 wks old, BALB/c, nu/nu, 7-8 wks old); pump implated IP; bevacizumab is a anti-VEGF antibody; "This delivery (using ALZET pumps) mimics local delivery of antivascular agents and can be used effectively alone or in combination with cytotoxic chemotherapy for site-specific drug delivery for lung cancer treatment. As expected, continuous infusion of bevacizumab decreased lung tumor volume and tumor perfusion, with an added survival advantage compared to the untreated group." pg 55; cancer (lung); antibody.

P9779 Ozawa,T., Gryaznov,S., Hu,L.J., Pongracz,K., Santos,R.A.S., Bollen,A.W., Lamborn,K.R., Deen,D.F. Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts1. NEURO-ONCOLOGY 2004/7; (--):218-226. >>> GRN163, FITC-; CSF/CNS (intratumoral); Rat (nude); 1007D; 7, 14 days; Tissue perfusion (tumor); enzyme inhibitor (telomerase); cancer (glioma); animal info (6-8 wks old, male, athymic).

P9777 Giraud,S., Bessette,B., Boda,C., Lalloue,F., Petit,D., Mathonnet,M., Jauberteau,M.O. In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. INTERNATIONAL JOURNAL OF ONCOLOGY 2007; 30(--):273-281. >>> Fas ligand; etoposide; dexamethasone; CSF, artificial; CSF/CNS (intratumoral); Rat (nude); 1002; 15 days; Tissue perfusion (tumor); functionality of mp verified by residual volume; cancer (glioblastoma); animal info (female 2 months old, 159 g.).

P9727 Skipper,J.B., McNally,L.R., Rosenthal,E.L., Wang,W.Q., Buchsbaum,D.J. In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 2009; 71(-1-):1-5. >>> Marimastat; DMSO; SC; Mice (nude); 2002; 14 days; Controls received mp w/vehicle; cancer; animal info (3 mo old, female).

P9674 Zerwes,H.G., Li,J., Kovarik,J., Streiff,M., Hofmann,M., Roth,L., Luyten,M., Pally,C., Loewe,R.P., Wieczorek,G., Baenteli,R., Thoma,G., Luckow,B. The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-8-):1604-1613. >>> Cyclosporin A; NIBR2130; SC; Mice; 2002; 2ML2; 14 days; Animal info (CXCR3 deficient, C47BL/6, 8-12 wks old); NIBR2130 is a CXCR3 inhibitor; functionality of mp verified by plasma drug levels.

P9548 Higuchi,K., Kimura,O., Furukawa,T., Kinoshita,H., Iwai,N. Bombesin can minimize impairments of interstitial cells of Cajal induced by FK506 in small bowel transplantation. Journal of Pediatric Surgery 2009; 44(-3-):541-545. >>> Bombesin; SC; Rat; 14 days; Controls received mp w/saline; animal info (male, Brown Norway, 250-300g, Lewis, 300-350g).

P9436 Reuter,S., Velic,A., Edemir,B., Schroeter,R., Pavenstaedt,H., Gabriels,G., Bleich,M., Schlatter,E. Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2008; 456(-6-):1075-1084. >>> NHE-3I4167; Water, sterile; SC; Rat; 2001; 5 days; Replacement therapy (nephrectomy); immunology; animal info (male, Lewis, Lewis Brown Norway, 240-290 g., kidney transplantation); nephrology; Nat/Ht Exchanger type 3 Inihibitor #4167).

P9410 Hasegawa,T., Iwanaga,K., Hultquist,D.E., Liao,H., Visovatti,S.H., Pinsky,D.J. Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-4-):H1007-H1016. >>> Riboflavin; Saline; IP; Mice; 1003D; 3 days; Controls received mp w/ vehicle; functionality of mp verified by plasma riboflavin levels; dose-response (fig. 1); cardiovascular; immunology; animal info (male, CBA/J, B1OA, 8-12 wks old, cardiac transplantation); antioxidant.

P9401 Cook,C.H., Bickerstaff,A.A., Wang,J.J., Zimmerman,P.D., Forster,M.R., Nadasdy,T., Colvin,R.B., Hadley,G.A., Orosz,C.G. Disruption of Murine Cardiac Allograft Acceptance by Latent Cytomegalovirus. AMERICAN JOURNAL OF TRANSPLANTATION 2009; 9(-1-):42-53. >>> Gallium nitrate; SC; Mice; 2002; 28 days; Controls received mp w/ agent and no transplantation; no stress (see pg. 44); cadiovascular; immunology; animal info (C57BL/6); heterotropic cardiac transplantation.

P9309 Lane,E.L., Soulet,D., Vercammen,L., Cenci,M.A., Brundin,P. Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease. NEUROBIOLOGY OF DISEASE 2008; 32(-2-):220-228. >>> Interleukin-2; Saline; CSF/CNS (striatum); Rat; 2002; 12 days; Controls received mp w/ vehicle; animal info (female, Sprague Dawley); neurodegenerative (Parkinson's Disease); behavioral testing (rotational behavior and locomotor; axial, limb, and orolingual movements).

P9167 Bretzner,F., Liu,J., Currie,E., Roskams,A.J., Tetzlaff,W. Undesired effects of a combinatorial treatment for spinal cord injury - transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus. European Journal of Neuroscience 2008; 28(-9-):1795-1807. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 300-400 g.); 28 gauge cannula, silastic tubing used; spinal cord injury; wound clips used.

P9116 Kwun,J., Hazinedaroglu,S.M., Schadde,E., Kayaoglu,H.A., Fechner,J., Hu,H.Z., Roenneburg,D., Torrealba,J., Shiao,L., Hong,X., Peng,R., Szewczyk,J.W., Sullivan,K.A., DeMartino,J., Knechtle,S.J. Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-8-):1593-1603. >>> Cyclosporin; SC; Mice; 1002; ; Animal info (male, C57BL/6, 6-8 wks old, Cxcr3-/-).

P9084 Zhang,J.J., Zafrullah,M., Yang,X., Yin,X.L., Zhang,Z.G., Fuks,Z., Kolesnick,R. Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. CANCER BIOLOGY&THERAPY 2008; 7(-9-):1492-1497. >>> Oligonucleotide, antisense; PBS; SC; Mice; 5 days; Controls received mp w/ vehicle; antisense (KSR1); cancer (pancreatic).

P9073 Shu,Q., Antalffy,B., Su,J.M., Adesina,A., Ou,C.N., Pietsch,T., Blaney,S.M., Lau,C.C., Li,X.N. Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin.Cancer Res. 2006/8/1; 12(-15-):4687-4694. >>> Valproic acid; Sodium chloride; SC; Mice (SCID); 2001; 14 days; Controls received no treatment; pumps replaced after 7 days; animal info (6-10 wks old, Rag 2).

P9064 Liu,X.M., Wang,Y.W., Li,D., Ju,X.L. Transplantation of rat neural stem cells reduces stereotypic behaviors in rats after intrastriatal microinfusion of Tourette syndrome sera. Behavioural Brain Research 2008; 186(-1-):84-90. >>> Serum, human; PBS; CSF/CNS (striatum); Rat; 72 hours; Controls received mp with control serum; animal info (male, female, Wistar, 7 wks old, 260-275 g.); pumps filled with PBS, PE tube filled with 50 ul Tourette syndrome sera; pumps implanted following 1 week recovery period from guide cannula implantation; rats were allowed 1 week recovery period prior to pump implantation.

P8878 Hontanilla,B., Auba,C., Gorria,O. Nerve regeneration through nerve autografts after local administration of brain-derived neurotrophic factor with osmotic pumps. Neurosurgery 2007; 61(-6-):1268-1274. >>> Brain-derived neurotrophic factor; Saline; CSF/CNS (sciatic nerve); Rat; 1002; 2 weeks; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve graft); replacement therapy (axotomy); no stress (see pg. 1270); stress/adverse reaction: (see pg. 1270) "one pump was extruded"; animal info (male, Wistar, 200-250g.); pg. 1269, fig A shows image of pump implantation and cannulae location.

P8865 Kobayashi,M., Okada,T., Murakami,T., Ozawa,K., Kobayashi,E., Morita,T. Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems. UROLOGY 2007; 70(-6-):1230-1236. >>> Ganciclovir; IP; Rat; 7 days; Gene therapy; animal info (male, ACI, 6-8 wks old).

P8782 Giraud,S., Barrou,B., Sebillaud,S., Debre,P., Klatzmann,D., Thomas-Vaslin,V. Transient depletion of dividing T lymphocytes in mice induces the emergence of regulatory T cells and dominant tolerance to islet allografts. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-5-):942-953. >>> Ganciclovir; Water, pyrogen-free; SC; Mice; mice (transgenic); 2001; 2002; 7, 14 days; STZ-induced diabetes, animal info (FVB EpCD4TK, FVB/N, B6 islet allograft, skin allograft).

P8702 Grumbles,R.M., Casella,G.T.B., Rudinsky,M.J., Wood,P.M., Sesodia,S., Bent,M., Thomas,C.K. Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. Journal of Neuroscience Research 2007; 85(-9-):1933-1942. >>> Fibroblast growth factor-6, recomb. human; PBS; BSA; IM (medial gastrocnemius); Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (female, Fischer, adult).

P8696 Babu,A.N., Murakawa,T., Thurman,J.M., Miller,E.J., Henson,P.M., Zamora,M.R., Voelkel,N.F., Nicolls,M.R. Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. Journal of Clinical Investigation 2007; 117(-12-):3774-3785. >>> Antileukinate; Saline; Hank's solution; SC; Mice; 1002; 6, 8, 10, 12, 14 days; Animal info (B6(H-2b), orthotopic tracheal transplant); CXCR2 antagonist; pulmonology.

P8634 Koyanagi,T., Noguchi,K., Ootani,A., Inagaki,K., Robbins,R.C., Mochly-Rosen,D. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):517-522. >>> Peptide, TAT (47-57); peptide TAT (47-57)-EV1-2; Saline, sterile; SC; Mice; 1002; 4 weeks; Controls received mp w/ TAT control peptide; pumps replaced after 14 days; no stress (see pg. 519); enzyme inhibitor (Epsilon PKC); cardiovascular; peptides; animal info (male, C57BL/6J (H-2b), 6-8 wks old); heterotopic cardiac transplantation.

P8504 Wilkinson,R.W., Odedra,R., Heaton,S.P., Wedge,S.R., Keen,N.J., Crafter,C., Foster,J.R., Brady,M.C., Bigley,A., Brown,E., Byth,K.F., Barrass,N.C., Mundt,K.E., Foote,K.M., Heron,N.M., Jung,F.H., Mortlock,A.A., Boyle,F.T., Green,S. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clinical Cancer Research 2007; 13(-12-):3682-3688. >>> AZD1152; SC; Mice; 2001D; 48 hours; Controls received mp w/ vehicle; dose-response (p. 3684); comparison of IV or IP injections; enzyme inhibitor (aurora B kinase); cancer; xenograft; animal info (male, 8-12 weeks old, Swiss athymic).

P8478 Ma,T., Gutnick,J., Salazar,B., Larsen,M.D., Suenaga,E., Zilber,S., Huang,Z., Huddleston,J., Smith,R.L., Goodman,S. Modulation of allograft incorporation by growth factors over a prolonged continuous infusion of duration in vivo. Bone 2007; 41(-3-):386-392. >>> Fibroblast growth factor-2; osteogenic protein-1, recomb. human; Water, distilled; acetate buffer; Bone (tibia); Rabbit; 2004; 4,36 weeks; Controls received no treatment to contralateral side; long-term study; pumps replaced every 4 weeks, with 4 week rest periods between 4 week infusion periods; animal info (New Zealand white, 6-12 months old, 3.5-4.2 kg); peptides; OP-1 also known as bone morphogenic protein-7 (BMP-7); tissue perfusion (tibia); unique drug test chamber and bone harvest chamber used in conjunction with mp.

P8394 Earle,S.A., El-Haddad,A., Patel,M.B., Ruiz,P., Pham,S.M., Majetschak,M. Prolongation of skin graft survival by exogenous ubiquitin. Transplantation 2006; 82(-11-):1544-1546. >>> Ubiquitin; albumin; Saline, normal; IP; Mice; 2002; 5,14 days; Controls received mp w/ vehicle, or albumin or no treatment; functionality of mp verified by serum ubiquitin levles; dose-response (fig. 1); no stress (see pg. 1546); immunology; peptides; animal info ( C3H/HEJ, DBA2, 22g., skin grafts); "Ubiquitin administration was well tolerated and body weight was similar in both groups" (pg. 1546).

P8367 Wranning,C.A., El-Akouri,R.R., Groth,K., Moelne,J., Parra,A.K., Braennstroem,M. Rejection of the transplanted uterus is suppressed by cyclosporine A in a semi-allogeneic mouse model. Human Reproduction 2007; 22(-2-):372-379. >>> Cyclosporin A; Propylene glycol; SC; Mice; 1007D; 7-10 days; Controls received mp w/ vehicle, or no treatment; functionality of mp verified by serum CyA levels; dose-response (Table 1); immunology; post op.care (buprenorphin, carprofen, cefuroxine); animal info (female, C57BL/6, B6CBAF1, 6-8 wks old, uterine transplant).

P8310 Singh,A.K., Gudehithlu,K.P., Litbarg,N.O., Sethupathi,P., Arruda,J.A.L., Dunea,G. Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochemical and Biophysical Research Communications 2007; 355(-1-):258-262. >>> Insulin; SC; Rat; 28 days; Replacement therapy (STZ-induced diabetes, pancreatectomy and autotransplanted into omentum; immunology; animal info (male, Sprague-Dawley, 150-200g.); nephrology.

P8295 Uesato,N., Fukui,K., Maruhashi,J., Tojo,A., Tajima,N. JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Experimental Hematology 2006; 34(-10-):1385-1392. >>> JTE-607; Cyclodextrin, 2-hydroxypropyl-beta; SC; Mice (SCID); 2001; 7 days; Controls received mp w/ vehicle; comparison of bolus injections vs. mp; cancer (leukemia); animal info (8-9 weeks old); xenograft; multiple cytokine inhibitor; antileukemic; "Administration of JTE-607 using osmotic pumps reduced the number of leukemic cells...and significantly prolonged the mouse survival..." p. 1386; 30% cyclodextrin used.

P8261 Si,Y., Ciccone,S., Yang,F.C., Yuan,J., Zeng,D., Chen,S., van de Vrugt,H.J., Critser,J., Arwert,F., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice. Blood 2006; 108(-13-):4283-4287. >>> Interferon-gamma, mouse; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; no stress (see pg. 4286); immunology; peptides; animal info (C57BL/6).

P8227 Cassis,L.A., Rateri,D.L., Lu,H., Daugherty,A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007; 27(-2-):380-386. >>> Angiotensin II; Saline; Mice; 2004; 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, C57BL/6, 9 weeks old, 27 grams); bone marrow transplantation, irradiation.

P8224 Menon,J., Soto-Pantoja,D.R., Callahan,M.F., Cline,J.M., Ferrario,C.M., Tallant,E.A., Gallagher,P.E. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Research 2007; 67(-6-):2809-2815. >>> Angiotensin (1-7); Saline; heparin; IV (jugular); Mice (nude); 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 2810); cancer (lung); peptides; animal info (male, athymic, 2-4 weeks old, 15-20 grams); "During the infusion period, the animals maintained their body weight as well as food and water consumption and showed no evidence of reduced motor function. Additionally, no gross pathological abnormalities were observed in major organs..indicating a lack of toxic side effects." (p. 2810).

P8140 Husen,B., Huhtinen,K., Saloniemi,T., Messinger,J., Thole,H.H., Poutanen,M. Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts. Endocrinology 2006; 147(-11-):5333-5339. >>> B10721325; estrone; DMSO; propanediol; SC; Mice (nude); 1002; 2 weeks; Controls received mp w/ vehicle; replacement therapy (ovariectomy); dose-response (p.5335); pumps replaced after 14 days; enzyme inhibitor (hydroxysteroid 17 beta dehydrogenase 1); cancer (breast); animal info (female, BALB/cA Bom-v, Crl: nu/nu, 10-11 wks old); 50%DMSO; endocrinology.

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P8084 Hirayama,S., Shiraishi,T., Shirakusa,T., Higuchi,T., Miller,E.J. Prevention of neutrophil migration ameliorates rat lung allograft rejection. MOLECULAR MEDICINE 2006; 12(-9-10-):208-213. >>> Antileukinate; PBS; IP; Rat; 2001; 7 days; Controls received mp w/ vehicle; comparison of bolus IM injection vs. mp; immunology; peptides; ischemia (lung); animal info (male, Fischer 344, 250-300g, left lung transplantation); mp primed 4 hrs in 37 celcius saline.

P8036 Yasuhara,T., Matsukawa,N., Hara,K., Yu,G.L., Xu,L., Maki,M., Kim,S.U., Borlongan,C.V. Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease. Journal of Neuroscience 2006; 26(-48-):12497-12511. >>> Stem cell factor, human recomb.; PBS; CSF/CNS (striatum); Rat; 2004; 4 weeks; Animal info (Sprague-Dawley, 200-250 grams); neurodegenerative (Parkinson's Disease); behavioral study; tissue perfusion (striatum).

P8003 Tocco,G., Illigens,B.M.W., Malfroy,B., Benichou,G. Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species. Cellular Immunology 2006; 241(-2-):59-65. >>> EUK-189; Mice; 8-10 days; Animal info (female, 6-8 weeks old, BALB/C and C57BL/6).

P7936 Bondanza,A., Valtolina,V., Magnani,Z., Ponzoni,M., Fleischhauer,K., Bonyhadi,M., Traversari,C., Sanvito,F., Toma,S., Radrizzani,M., La Seta-Catamancio,S., Ciceri,F., Bordignon,C., Bonini,C. Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes. Blood 2006; 107(-5-):1828-1836. >>> Ganciclovir; SC; Mice (SCID); 2001; 7 days; Controls received mp w/ saline; animal info (female, NOD/SCID, 6-8 weeks old, GvHD); gene therapy.

P7877 Kaneko,H., Kikuchi,K., Noguchi,J., Ozawa,M., Ohnuma,K., Maedomari,N., Kashiwazaki,N. Effects of gonadotrophin treatments on meiotic and developmental competence of oocytes in porcine primordial follicles following xenografting to nude mice. REPRODUCTION 2006; 131(-2-):279-288. >>> Follicle-stimulating hormone, porcine; Saline; SC; Mice (nude); 2004; 7, 14 days; Controls received no hormone treatment; replacement therapy (ovariectomy); dose-response (pg. 280); animal info (female, Crlj: CD1-Foxn1nu, 5-6 wk old); ovarian xenografts.

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P7791 Ulusal,B.G., Ulusal,A.E., Hung,L.M., Wei,F.C. The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: An in vivo preliminary study. Journal of Surgical Research 2006; 131(-2-):261-266. >>> CGS 21680; SC; Rat; 7 days; Controls received no treatment; no stress (see pg. 263); immunology; animal info (Brown Norway, Lewis, Hindlimb transplantation); A-2a adenosine receptor agonist; "The animals tolerated the minipumps well." (pg.263).

P7675 Kinoshita,H., Kimura,O., Furukawa,T., Higuchi,K., Chujo,S., Iwai,N. Preoperative bombesin administration can protect the rat small bowel allograft from ischemic reperfusion injury. Journal of Pediatric Surgery 2005; 40(-12-):1877-1880. >>> Bombesin; SC; Rat; 2002; ; Animal info (male, Lewis, 250-300 g); neuropeptide.

P7579 Svetlecic,J., Molteni,A., Chen,Y.Y., Al-Hamed,M., Quinn,T., Herndon,B. Transplant-related bronchiolitis obliterans (BOS) demonstrates unique cytokine profiles compared to toxicant-induced BOS. Experimental and Molecular Pathology 2005; 79(-3-):198-205. >>> Papaverine HCl; CSF/CNS (intrathecal); Rat; 7, 28 days; Controls received mp w/ saline; animal info (Sprague-Dawley).

P7563 Ikegami,T., Nakamura,M., Yamane,J., Katoh,H., Okada,S., Iwanami,A., Watanabe,K., Ishii,K., Kato,F., Fujita,H., Takahashi,T., Okano,H.J., Toyama,Y., Okano,H. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-12-):3036-3046. >>> Chondroitinase ABC; Saline, physiological; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 1 week; Controls received mp w/ heat inactivated agent; stability verified by ALZAID chemical compability test kit for 7 days; animal info (adult, female, Sprague-Dawley 230-250 g); mp primed overnight in 37 C saline; spinal cord injury.

P7469 Gottmann,U., Notheisen,A., Brinkkoetter,P.T., Yard,B.A., Waldherr,R., Schnuelle,P., van der Woude,F.J., Braun,C. Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats. Transplantation 2005; 79(-10-):1344-1350. >>> Dopamine; Saline; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ vehicle; animal info (male, Lewis Fisher).

P7460 Roychowdhury,S., Blaser,B.W., Freud,A.G., Katz,K., Bhatt,D., Ferketich,A.K., Bergdall,V., Kusewitt,D., Baiocchi,R.A., Caligiuri,M.A. IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease. Blood 2005; 106(-7-):2433-2435. >>> Interleukin-15, recomb. human; interleukin-2, recomb. human; PBS; albumin, human; SC; Mice (SCID); 1007D; 10 days; Controls received mp w/ vehicle; immunology; animal info (female, CB17, hu-PBL-SCID, 8-12 weeks old).

P7417 Schmidt,N.O., Przylecki,W., Yang,W., Ziu,M., Teng,Y., Kim,S.U., Black,P.M., Aboody,K.S., Carroll,R.S. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. NEOPLASIA 2005; 7(-6-):623-629. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS (parenchyma); Mice; 2004; ; Controls received mp w/ PBS; functionality of mp verified by residual volume; cancer.

P7408 Rissler,P., Soederdahl,G., Nordman,T., Xia,L., Torndal,U.B., Bjoernstedt,M., Ericzon,B.G., Olsson,J.M., Eriksson,L.C. Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation. TRANSPLANT INTERNATIONAL 2005; 18(-8-):992-1000. >>> Uridine, bromodeoxy-; NaOH; SC; Rat; ; Labeling of hepatocytes; animal info (male, wistar-kyoto, 4-5 weeks old, 110 g).

P7321 Aparicio,T., Kotelevets,L., Tsocas,A., Laigneau,J.P., Sobhani,I., Chastre,E., Lehy,T. Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice. Gut 2005; 54(-8-):1136-1145. >>> Leptin, recomb. human; leptin, recomb. murine; Saline, BSA; SC; Mice (nude); mice; 2002; 4, 6 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma leptin levels; pumps replaced every 2 weeks; cancer (colon, intestinal adenoma); peptides.

P7167 Fujii,T., Nagaya,N., Iwase,T., Murakami,S., Miyahara,Y., Nishigami,K., Ishibashi-Ueda,H., Shirai,M., Itoh,T., Ishino,K., Sano,S., Kangawa,K., Mori,H. Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-3-):H1444-H1450. >>> Adrenomedullin, recomb.human; Glucose; saline; SC; Rat; 2004; 4 weeks; 3 days; Controls received mp w/ vehicle, cardiovascular, peptides, ischemia (cardiac), acute myocardial infarction.

P7136 Bandyopadhyay,A., Wang,L., Loepz-Casillas,F., Mendoza,V., Yeh,I.T., Sun,L.Z. Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer. PROSTATE 2005; 63(-1-):81-90. >>> Transforming growth factor-B3 receptor, recomb. soluble; PBS; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; comparison of IP injections vs. mp; no stress (see pg. 84,88); cancer (prostate); multiple pumps per animal (2).

P7081 Matsuno,A., Katayama,H., Murakami,M., Nagashima,T. In vivo growth suppression of rat C6 glioma transplanted in rat brain using antisense oligonucleotide for microtubule-associated protein 1A messenger ribonucleic acid. British Journal of Neurosurgery 2004; 18(-4-):343-346. >>> Oligodeoxynucleotide, phosphorothisate antisense; oligodeoxynucleotide, phosphorothisate sense; oligodeoxynucleotide, phosphorothisate scramble; Saline, sterile; CSF/CNS (intratumoral); Rat; 1007D; 1 week; Controls received mp w/ sense or scrambled oligos; antisense (microtubule-associated protein 1A); cancer (glioma).

P7075 Thijssen,V.L.J.L., Brandwijk,R.J.M.G., Dings,R.P.M., Griffioen,A.W. Angiogenesis gene expression profiling in xenograft models to study cellular interactions. Experimental Cell Research 2004; 299(-2-):286-293. >>> Anginex; Saline; SC; Mice (nude); 2004; 20 days; Controls received mp w/ vehicle; cancer (melanoma, ovarian carcinoma).

P7074 Robinson,G.A., Madison,R.D. Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. Vision Research 2004; 44(-23-):2667-2674. >>> Saline, normal; SC; Mice; 1007D; 7 days; Optic nerve transection and grafting to create model for retinal ganglion cell survival and axon regrowth; regeneration.

P7073 Thallinger,C., Wolschek,M.F., Maierhofer,H., Skvara,H., Pehamberger,H., Monia,B.P., Jansen,B., Wacheck,V., Selzer,E. Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of Mcl-1 antisense Oligonucleotides with low-dose cyclophosphamide. Clinical Cancer Research 2004; 10(-12-):4185-4191. >>> Oligodeoxynucleotide, phosphorothisate antisense; oligonucleotide, universal control; Saline; SC; Mice (SCID); 2002; 2 weeks; Controls received mp w/ vehicle, or UC oligo; antisense (Mcl-1); cancer (liposarcoma).

P7042 Li,X.X., Yang,Y.Z., Yuan,J., Hong,P., Freie,B., Orazi,A., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc(-/-) mice. Blood 2004; 104(-4-):1204-1209. >>> Interferon-gamma, murine; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; dose-response (fig. 7); no stress (pg. 1209); stress/adverse reaction: (see pg. 1205) "modest though not significant rise in peripheral white blood cell count" (pg. 1205); "IFN-gamma was overall well tolerated by both WT and Fancc -/- mice." (pg. 1208); hematology.

P7028 Harrington,K.J., Syrigos,K.N., Uster,P.S., Zetter,A., Lewanski,C.R., Gullick,W.J., Vile,R.G., Stewart,J.S.W. Targeted radiosensitisation by pegylated liposome-encapsulated 3', 5'-O-dipalmitoyl 5-iodo-2'-deoxyuridine in a head and neck cancer xenograft model. British Journal of Cancer 2004; 91(-2-):366-373. >>> Uridine, iododeoxy-; DMSO; water distilled; SC; Mice (nude); 2002; 7 days; Controls received PBS injections; comparison of pegylated liposomes vs. IV bolus injections vs. mp; no stress (pg. 370); cancer (head and neck); toxicology; 20% DMSO; therapeutic irradiation with 137Cs source after day 7.

P6950 Chen,W.H., Langer,R.M., Janczewska,S., Furian,L., Geary,R., Qu,X.M., Wang,M., Verani,R., Condon,T., Stecker,K., Bennett,C.F., Stepkowski,S.M. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation 2005; 79(-4-):401-408. >>> Oligonucleotide, antisense; Saline; IV; Rat; 7 days; Comparison of gavage and IV injections vs. mp; antisense (phosphorothioate/phosphodiester); transplantation; 14 d pump used; immunology.

P6949 Fowler,M., Virostko,J., Chen,Z.Y., Poffenberger,G., Radhika,A., Brissova,M., Shiota,M., Nicholson,W.E., Shi,Y.B., Hirshberg,B., Harlan,D.M., Jansen,E.D., Powers,A.C. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005; 79(-7-):768-776. >>> Insulin, human; SC; Mice (SCID); 1002; 7,10 days; Diabetes; bioluminescence imaging (BLI); IVIS 200 system used after pumps were removed.

P6927 Borgal,L., MacLeod,M., Hong,M., Lewington,M., Sadi,D., Mendez,I. Effect of local liposomal tacrolimus on cell survival and behavioural recovery following double co-grafts of VM and GDNF-C17.2 cells in the 6-OHDA rat model of Parkinson's disease. Experimental Neurology 2004; 187(-1-):225-225. >>> Rotenone; IV (jugular); Rat; 2 weeks; Neurodegenerative (Parkinson's disease).

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P6814 Wang,Q.C., Horiatis,D., Pinski,J. Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation. International Journal of Cancer 2004; 111(-4-):508-513. >>> Interleukin-6; SC; Mice (nude); 3 weeks; Controls received SC saline injections; comparison of SC injections vs. mp; no stress (see pg. 511); cancer (prostate).

P6806 Haninec,P., Dubovy,P., Samal,F., Houstava,L., Stejskal,L. Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots: a comparison of intrathecal administration of brain-derived neurotrophic factor and Cerebrolysin. Experimental Brain Research 2004; 159(-4-):425-432. >>> Brain-derived neurotrophic factor; cerebrolysin; PBS; CSF/CNS (intrathecal); Rat; 2002; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; ALZET brain infusion kit 2 used; C5 ventral root avulsion; "indicating a superior availability and effect of neuron-promoting agents after their continuous intrathecal rather than single or intravenous administration even if their concentrations were lower." (p. 430).

P6790 Seo,Y., Yan,T., Schupp,J.E., Colussi,V., Taylor,K.L., Kinsella,T.J. Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2-deoxyribose. Clinical Cancer Research 2004; 10(-22-):7520-7528. >>> Uridine, iododeoxy; NaOH; SC; Mice (nude); 2001; 7 days; Comparison of oral IPdR vs. mp; cancer (colon); athymic; "the use of oral IPdR results in dramatically higher but transient plasma IUdR levels in comparison with continuous infusion IUdR." (p. 7523).

P6785 Luckow,B., Joergensen,J., Chilla,S., Li,J.P., Henger,A., Kiss,E., Wieczorek,G., Roth,L., Hartmann,N., Hoffmann,R., Kretzler,M., Nelson,P.J., de Lema,G.P., Maier,H., Wurst,W., Balling,R., Pfeffer,K., Groene,H.J., Schloendorff,D., Zerwes,H.G. Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. European Journal of Immunology 2004; 34(-9-):2568-2578. >>> Cyclosporin A; SC; Mice; 2002; ; Heart transplant; cardiovascular.

P6646 Aharinejad,S., Paulus,P., Sioud,M., Hofmann,M., Zins,K., Schaefer,R., Stanley,E.R., Abraham,D., Aharinejad,S. Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Research 2004; 64(--):5378-5384. >>> Oligonucleotide, antisense; oligonucleotide, scrambled; Ringer's solution; SC; Mice (nude); 1002; 14 days; Controls received mp w/ vehicle; antisense (CSF)-1; cancer (carcinoma, breast); transplantation.

P6538 Grimpe,B., Silver,J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. Journal of Neuroscience 2004; 24(-6-):1393-1397. >>> Oligodeoxyribonucleotide, phosphorothioated; CSF/CNS (intrathecal, subarachnoid space); Mice; 1007D; 7 days; Controls received mp w/ control DNA enzyme; antisense (xylosyltransferase-1); spinal cord injury; PE-60 tubing connected to PE-10 tubing for IT delivery; DNA enzyme against xylosyltransferase-1 (XT-1).

P6535 Fischer,W., Gustafsson,L., Mossberg,A.K., Gronli,J., Mork,S., Bjerkvig,R., Svanborg,C. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Research 2004; 64(-6-):2105-2112. >>> Lactalbumin, alpha; HAMLET; radio-isotopes; 125I tracer; saline; CSF/CNS (intratumoral); Rat (nude); 2001D; 1 day; Tissue perfusion (tumor); functionality of mp verified by autoradiography on brain sections; no stress (see pg. 2108); cancer (glioblastoma); brain tissue distribution; agent is called HAMLET or (human alpha lact albumin made lethal to tumor cells); "...there were no signs of edema or tissue damage in the surrounding brain, including the cortex, which had been penetrated by the [26 gauge] infusion cannula." p. 2108.

P6352 Akhtar,N., Padilla,M.L., Dickerson,E.B., Steinberg,H., Breen,M., Auerbach,R., Helfand,S.C. Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft model. NEOPLASIA 2004; 6(-2-):106-116. >>> Interleukin-12; PBS; SC; Mice (SCID); 2004; 1 week; Controls received mp w/ vehicle; functionality of mp verified by pump explantation, examination and tumor reduction; cancer (Hemangiosarcoma); peptides; pump model not listed; tumor cells from a canine.

P6344 El-Salhy,M., Dennerqvist,V. Effects of triple therapy with octreotide, galanin and serotonin on liver metastasis of human colon cancer in xenografts. Oncology Reports 2004; 11(--):1177-1182. >>> Octreotide; galanin; serotonin; Saline; IP; Mice (nude); 1002; 14 days; Controls received mp w/ vehicle; no stress (pg. 1179); cancer (colon).

P6265 Tepel,J., Kruse,M.L., March,C., Fiedler,A., Kapischke,M., Ketterer,T., Sipos,B., Kremer,B., Kalthoff,H. Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: A novel adjuvant treatment strategy for pancreatic ductal carcinoma. Pancreas 2004; 28(-1-):1-12. >>> Oligodeoxynucleotide, antisense; SC; Mice (SCID); 14 days; Tissue perfusion (intratumoral); comparison of IP injections vs. sc mp; cancer (pancreatic ductal carcinoma); transplantation; 200 ul pump used.