References on Transplantation Research Using ALZET® Osmotic Pumps

Q4080 Saleh,M.A., McMaster,W.G., Wu,J., Norlander,A.E., Funt,S.A., Thabet,S.R., Kirabo,A., Xiao,L., Chen,W., Itani,H.A., Michell,D., Huan,T.X., Zhang,Y.H., Takaki,S., Titze,J., Levy,D., Harrison,D.G., Madhur,M.S., Madhur,M.S. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. Journal of Clinical Investigation 2015; 125(--):1189-1202. >>> Exendin-4; Saline; SC; Mice; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (CAnN.Cgt-Foxn1nu/CrlCrlj, athymic, 6 weeks old); cancer (prostate);.

Q4015 Navaratnarajah,M., Siedlecka,U., Ibrahim,M., van Doorn,C., Soppa,G., Gandhi,A., Shah,A., Kukadia,P., Yacoub,M.H., Terracciano,C.M., Navaratnarajah,M. Impact of Combined Clenbuterol and Metoprolol Therapy on Reverse Remodelling during Mechanical Unloading. PLoS One 2014; 9(--):U31-U41. >>> Clenbuterol; SC; Rat; 2002; 4 weeks; Controls received mp w/ saline; animal info (male, Lewis, 10 weeks old, 200g); functionality of mp verified by blood levels; ischemia (cardiac); cardiovascular; clenbuterol is a B2 agonist;.

Q3975 Liang,P., Liu,J.R., Xiong,J.S., Liu,Q., Zhao,J.X., Liang,H.S., Zhao,L.W., Tang,H.T., Liang,P. Neural Stem Cell-Conditioned Medium Protects Neurons and Promotes Propriospinal Neurons Relay Neural Circuit Reconnection After Spinal Cord Injury. CELL TRANSPLANTATION 2014; 23(--):S45-S56. >>> Neural stem cell-conditioned medium, human fetal; CSF/CNS (intrathecal); Rat; 2001; 4 weeks; Controls received mp w/ NSC culture medium; animal info (female, Wistar, 8-10 weeks old, 260-300g); pumps replaced every week; spinal cord injury; post op. care (Bicillin injection 20000 U/day, bladder massage); behavioral testing (locomotor activity); pumps primed in 37C saline overnight; pumps removed after 4 weeks of infusion;.

Q3856 az-Garcia,C., Johannesson,L., Shao,R.J., Bilig,H., Braennstroem,M., az-Garcia,C. Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory. Fertility and Sterility 2014; 102(--):1545-U353. >>> Tacrolimus; NaCl; SC; Rat; 2ML4; 2004; 8 weeks; Controls received mp w/ vehicle; animal info (female, Lewis, virgin); functionality of mp verified by blood levels; pumps replaced every 2 weeks; teratology;.

Q3822 Cao,X.C., Han,Z.B., Zhao,H., Liu,Q., Cao,X.C. Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice. INTERNATIONAL JOURNAL OF BIOCHEMISTRY&CELL BIOLOGY 2014; 53(--):372-379. >>> AMD3100; PBS; SC; Mice; ; Controls received mp w/ vehicle; animal info (male, C57BL, 8 weeks old); cardiovascular; immunology;.

Q3758 Ishikawa,M., Ito,H., Kitaori,T., Murata,K., Shibuya,H., Furu,M., Yoshitomi,H., Fujii,T., Yamamoto,K., Matsuda,S., Ito,H. MCP/CCR2 Signaling Is Essential for Recruitment of Mesenchymal Progenitor Cells during the Early Phase of Fracture Healing. PLoS One 2014; 9(--):U587-U595. >>> RS102895; DMSO; Mice; 1002; 14 days; Control animals received mp w/ vehicle; animal info (MCP-1, MCP-3); RS102895 is a selective CCR2 antagonist.

Q3703 Michineau,S., Franck,G., Wagner-Ballon,O., Dai,J.P., Allaire,E., Gervais,M., Gervais,M. Chemokine (C-X-C Motif) Receptor 4 Blockade by AMD3100 Inhibits Experimental Abdominal Aortic Aneurysm Expansion Through Anti-Inflammatory Effects. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2014; 34(--):1747-+. >>> AMD3100; SC; Mice; 2002; 10 days; Controls received mp w/ vehicle; animal info (male, C57BL6, 8 weeks old); cardiovascular; AMD3100 is a CXCR4 receptor antagonist.

Q3617 Rowinska,Z., Gorressen,S., Merx,M.W., Koeppel,T.A., Liehn,E.A., Zernecke,A., Rowinska,Z. Establishment of a New Murine Elastase-Induced Aneurysm Model Combined with Transplantation. PLoS One 2014; 9(--):U147-U153. >>> ; Mice; ; Animal info (C57Bl6, 8-12 weeks); mouse jugular catheter only;.

Q3601 Pileggi,A., Klein,D., Fotino,C., Bravo-Egana,V., Rosero,S., Doni,M., Podetta,M., Ricordi,C., Molano,R.D., Pastori,R.L. MicroRNAs in islet immunobiology and transplantation. Immunologic Research 2013; 57(-1-3-):185-196. >>> Morpholinos; Kidney (renal subcapsular space); Rat; ; Gene therapy; diabetes; Used silicone catheter 3 french; morpholinos are DNA mimics, miRNA inhibitors.

Q3600 Piccin,D., Tufford,A., Morshead,C.M., Morshead,C.M. Neural stem and progenitor cells in the aged subependyma are activated by the young niche. NEUROBIOLOGY OF AGING 2014; 35(--):1669-1679. >>> SB216763; DMSO; CSF/CNS; Mice; 1007D; 4 days; Controls received mp w/ vehicle; animal info (CD1 and YPF, young mice 8-10 weeks old or old mice 18-22 months old ); aging; SB216763 is a GSK-3B inhibitor;.

Q3539 Krautz,C., Wolk,S., Steffen,A., Knoch,K.P., Ceglarek,U., Thiery,J., Bornstein,S., Saeger,H.D., Solimena,M., Kersting,S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 2013; 56(-7-):1596-1604. >>> Uridine, bromodeoxy-; everolimus; tacrolimus; mycophenolate mofetil; sirolimus; DMSO; IP; Mice; 1004; 28 days; Controls received mp w/ BrdU only; animal info (C57BL6, 10-12 weeks old, STZ); functionality of mp verified by blood levels; 100% DMSO used; stress/adverse reaction: (see pg.1598); toxicology; diabetes;.

Q3418 Bentzinger,C.F., von Maltzahn,J., Dumont,N.A., Stark,D.A., Wang,Y.X., Nhan,K., Frenette,J., Cornelison,D.D.W., Rudnicki,M.A., Rudnicki,M.A. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. Journal of Cell Biology 2014; 205(--):97-111. >>> FK506; Mice (transgenic); 3 days; Animal info (C57BL6); FK506 aka tacrolimus; FK506 is an immunosuppressant.

Q3417 Ben Menachem-Zidon,O., Ben Menahem,Y., Ben Hur,T., Yirmiya,R. Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer's Disease Model. Neuropsychopharmacology 2014; 39(-2-):401-414. >>> Interleukin-1, receptor antagonist; CSF/CNS; Mice (transgenic); 28 days; Controls received mp w/ vehicle; animal info (WT and Tg2576, 11 months old); pumps replaced every 2 weeks; ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); behavioral testing (fear conditioning; morris water maze); stability verified by (IL-1-ra remains effective for 2 weeks in pumps); Used three anchoring screws;.

Q3372 Yun,H.M., Kim,H.S., Park,K.R., Shin,J.M., Kang,A.R., Lee,K.I., Song,S., Kim,Y.B., Han,S.B., Chung,H.M., Hong,J.T. Placenta-derived mesenchymal stem cells improve memory dysfunction in an Abeta(1-42)-infused mouse model of Alzheimer's disease. Cell Death&Disease 2013; 4(-;-):U202-U211. >>> Amyloid protein, beta (1-42); Saline; CSF/CNS; Mice; 1002; 14 days; Animal info (male, ICR mice, 20-25g); neurodegenerative (Alzheimer's disease); behavioral testing (Morris water maze, probe test, passive avoidance); immunology;.

Q3367 Wang,L., Li,Y.L., Zhang,C.C., Cui,W., Wang,X., Xia,Y., Du,J., Li,H.H. Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation. Cardiovascular Research 2014; 101(-3-):383-392. >>> Angiotensin II; Saline; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, TLR2KO and C57BL/6 WT, 10-12 weeks old); cardiovascular; immunology; peptides; bp measured using tail-cuff;.

Q3337 Erion,J.R., Wosiski-Kuhn,M., Dey,A., Hao,S., Davis,C.L., Pollock,N.K., Stranahan,A.M. Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity. Journal of Neuroscience 2014; 34(-7-):2618-2631. >>> IL-1 receptor antagonist; Cerebrospinal fluid, artificial; CSF/CNS (hippocampus); Mice; 2 weeks; Animal info (male, db/db C57BL6J); functionality of mp verified by ELISA of hippocampal IL1ra; behavioral testing (spatial recognition memory testing, novel-object preference, treadmill running); tissue perfusion (hippocampus); immunology; diabetes; Cannula placement verified via histology; Used Plastics One cannula.

Q3302 Karpova,D., Dauber,K., Spohn,G., Chudziak,D., Wiercinska,E., Schulz,M., Pettit,A.R., Levesque,J.P., Romagnoli,B., Patel,K., Chevalier,E., Dembowsky,K., Bonig,H. The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor. LEUKEMIA 2013; 27(-12-):2322-2331. >>> POL5551; PBS; SC; Mice; 2001; ; Controls received mp w/saline; animal info (C57BL/6, 12 week old); dose-response (Figure 4A p.2328); immunology; peptides; POL5551 is a CXCR4 antagonist.

Q3233 Khuu,D.N., Nyabi,O., Maerckx,C., Sokal,E., Najimi,M. Adult Human Liver Mesenchymal Stem/Progenitor Cells Participate in Mouse Liver Regeneration After Hepatectomy. CELL TRANSPLANTATION 2013; 22(-8-):1369-1380. >>> Uridine, bromodeoxy;; IP; Mice (SCID); 3 days; 14 days; 28 days.

Q3179 Okamoto,T., Okamoto,S., Fujimoto,Y., Tabata,Y., Uemoto,S. Suppression of acute rejection by administration of prostaglandin E(2) receptor subtype 4 agonist in rat organ transplantation models. Journal of Surgical Research 2013; 183(-2-):852-859. >>> CAY10580; DMSO; saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (Brown Norway Rats, Lewis Rats, male, 200-300g, 7-10 weeks old); 10% DMSO used; immunology; CAY10580 aka EP4 agonist;.

Q3135 Tian,J.D., Dang,H., Chen,Z.Y., Guan,A., Jin,Y.L., Atkinson,M.A., Kaufman,D.L. gamma-Aminobutyric Acid Regulates Both the Survival and Replication of Human beta-Cells. Diabetes 2013; 62(-11-):3760-3765. >>> Muscimol; PBS; SC; Mice (NOD/SCID); 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL6, 10 weeks old; NOD/SCID); diabetes.

Q3114 Liu,X.M., Wang,X.M., Li,L.X., Wang,H.Y., Jiao,X.L. Influence of Mesenchymal Stem Cell Transplantation on Stereotypic Behavior and Dopamine Levels in Rats with Tourette Syndrome. PLoS One 2013; 8(-4-):U392-U398. >>> Serum, human, Tourette; PBS; CSF/CNS; Rat; 72 hours; Animal info (Wistar, 7-8 weeks old); post op. care (thermal pad, 65000 units sodium penicillin IM); behavioral testing (observation of stereotypic behavior); Lynch coil - agent was placed in PE tube with 50ul sera. Pump contained PBS. Pumps used to induce Tourette-like symptoms in mice..

Q3100 Krause,D.S., Fulzele,K., Catic,A., Sun,C.C., Dombkowski,D., Hurley,M.P., Lezeau,S., Attar,E., Wu,J.Y., Lin,H.Y., vieti-Pajevic,P., Hasserjian,R.P., Schipani,E., Van Etten,R.A., Scadden,D.T. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine 2013; 19(-11-):1513-+. >>> Parathyroid hormone, human (1-34); Saline; Mice (NSG); 4 weeks; 14 weeks; Controls received mp w/ vehicle; animal info (NSG; BALB/c); pumps replaced every 2 weeks; cancer (leukemia); immunology; peptides.

Q3075 Cantinieaux,D., Quertainmont,R., Blacher,S., Rossi,L., Wanet,T., Noel,A., Brook,G., Schoenen,J., Franzen,R. Conditioned Medium from Bone Marrow-Derived Mesenchymal Stem Cells Improves Recovery after Spinal Cord Injury in Rats: An Original Strategy to Avoid Cell Transplantation. PLoS One 2013; 8(-8-):U18-U32. >>> Conditioned medium, bone marrow-derived mesenchimal stem cells; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Controls received mp w/ control medium; animal info (female, Wistar, adult, 200g); spinal cord injury; post op. care (manually emptied bladder until rats regained control); behavioral testing (BBB open-field test, grid navagation test); tissue perfusion (spinal cord injury site); cardiovascular; immunology; Bone marrow-derived mesenchymal stem cells conditioned medium aka BMSC-CM; Pumps removed after 7 days.

Q3034 Suzuki,N., Yamazaki,S., Yamaguchi,T., Okabe,M., Masaki,H., Takaki,S., Otsu,M., Nakauchi,H. Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation. MOLECULAR THERAPY 2013; 21(-7-):1424-1431. >>> Stem cell factor, human recomb.;; SC; Mice (NOD/SCID); 2 weeks; Animal info (NOD/SCID (male, 5-7 weeks old); KSN/Slc (4-5 weeks old)); immunology; peptides.

Q3003 Nishimura,R., Nishioka,S., Fujisawa,I., Shiku,H., Shimada,M., Sekiguchi,S., Fujimori,K., Ushiyama,A., Matsue,T., Ohuchi,N., Satomi,S., Goto,M. Tacrolimus Inhibits the Revascularization of Isolated Pancreatic Islets. PLoS One 2013; 8(-4-):U30-U37. >>> Tacrolimus; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6-Tg, 9-12 wks); functionality of mp verified by tacrolimus plasma levels.

Q2992 Koellensperger,E., Niesen,W., Kolbenschlag,J., Gramley,F., Germann,G., Leimer,U. Human Adipose Tissue Derived Stem Cells Promote Liver Regeneration in a Rat Model of Toxic Injury. STEM CELLS INTERNATIONAL 2013; ;(-;-):U1-U10. >>> Cyclosporine; IP; Rat; 2ML4; 12 weeks; Animal info (Sprague Dawley, model of toxic liver damage (two-thirds hepatectomy)); immunology; pumps replaced every 28 days; long-term study.

Q2869 Denroche,H.C., Quong,W.L., Bruin,J.E., Tuduri,E., Asadi,A., Glavas,M.M., Fox,J.K., Kieffer,T.J. Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice. Diabetes 2013; 62(-8-):2738-2746. >>> Leptin, recomb. murine; Water; SC; Mice; 2006; 4, 6 weeks; Control animals received mp w/ vehicle; animal info (C57BL/6, male); dose-response; 4 week pumps used; diabetes;.

Q2850 Ye,P., Chen,W.H., Wu,J., Huang,X.F., Li,J., Wang,S.H., Liu,Z., Wang,G.H., Yang,X., Zhang,P., Lv,Q.L., Xa,J.H. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. Journal of Clinical Investigation 2013; 123(-5-):2317-2331. >>> Smad3 inhibitor; Mice; 1 week; Control animals received mp w/ vehicle; animal info (Smad3 -/-, male, female, wt).

Q2719 Hawryluk,G.W.J., Mothe,A., Wang,J., Wang,S., Tator,C., Fehlings,M.G. An In Vivo Characterization of Trophic Factor Production Following Neural Precursor Cell or Bone Marrow Stromal Cell Transplantation for Spinal Cord Injury. STEM CELLS AND DEVELOPMENT 2012; 21(-12-):2222-2238. >>> Epidermal growth factor; fibroblast growth factor, beta; platelet-derived growth factor, alpha; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Animal info (adult, female, tg).

Q2700 Yu,Z., Ricciotti,E., Miwa,T., Liu,S.L., Ihida-Stansbury,K., Landersberg,G., Jones,P.L., Scalia,R., Song,W.C., Assoian,R.K., FitzGerald,G.A. Myeloid Cell 5-Lipoxygenase Activating Protein Modulates the Response to Vascular Injury. Circulation Research 2013; 112(-3-):432-U71. >>> Uridine, bromodeoxy; SC; Mice; 28 days; Animal info (C57BL/6, FLAP KO, male, 12 wks old).

Q2676 Tao,F., Li,Q., Liu,S., Wu,H.Y., Skinner,J., Hurtado,A., Belegu,V., Furmanski,O., Yang,Y., McDonald,J.W., Johns,R.A. Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain. Stem Cells 2013; 31(-1-):83-91. >>> RNA, small interfering; CSF/CNS (intrathecal); Rat; 2004; 28 days; Control animals received mp w/ non target RNA; animal info (Long Evans, female, 250 g); NRG1 siRNA; spinal cord injury.

Q2550 Zhou,Z.L., Zhang,H., Jin,A.M., Min,S.X., Yu,B., Chen,Y.H. A combination of taxol infusion and human umbilical cord mesenchymal stem cells transplantation for the treatment of rat spinal cord injury. Brain Research 2012; 1481(-;-):79-89. >>> Paclitaxel; Ethanol; cremophor EL; CSF/CNS (intrathecal); Rat; 2004; 28 days; Control animals received mp w/ PBS; animal info (Sprague Dawley, female, 200-250 g); Paclitaxel also known as Taxol; 50% ethanol used; 50% cremophor EL used; spinal cord injury.

Q2544 Azar,Y., Shainer,R., mogi-Hazan,O., Bringer,R., Compton,S.R., Paidas,M.J., Barnea,E.R., Or,R. PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model). BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 2013; 19(-4-):519-528. >>> PreImplantation factor, synthetic; PreImplantation factor, scrambled; PBS; SC; Mice; 1002; 14 days; Control animals received mp w/ vehicle; peptides.

Q2415 Fainstein,N., Cohen,M.E., Ben-Hur,T. Time associated decline in neurotrophic properties of neural stem cell grafts render them dependent on brain region-specific environmental support. NEUROBIOLOGY OF DISEASE 2013; 49(-;-):41-48. >>> Antibody, anti-beta 1 integrin; CSF/CNS (striatum); Mice; 28 days; Control animals received mp w/ isotype control; animal info (C57BL/6, female).

Q2382 Zachrisson,O., Zhao,M., Andersson,A., Dannaeus,K., Haeggblad,J.H., Isacson,R., Nielsen,E., Patrone,C., Roennholm,H., Wikstrom,L., Delfani,K., McCormack,A.L., Palmer,T., Di Monte,D.A., Hill,M.P., Lang,A.M.J., Haegerstrand,A. Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson's Disease. JOURNAL OF PARKINSONS DISEASE 2011; 1(-1-):49-63. >>> Ara-C; platelet-derived growth factor; uridine, bromodeoxy; CSF/CNS; Mice; rat; 2002; 14 days; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 280-350 g, C57BL/6, 10 wks old); neurodegenerative (Parkinson's disease).

Q2353 Citro,A., Cantarelli,E., Maffi,P., Nano,R., Melzi,R., Mercalli,A., Dugnani,E., Sordi,V., Magistretti,P., Daffonchio,L., Ruffini,P.A., Allegretti,M., Secchi,A., Bonifacio,E., Piemonti,L. CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. Journal of Clinical Investigation 2012; 122(-10-):3647-3651. >>> Reparixin; SC; Mice; 6 days; Control animals received mp w/ vehicle; animal info (BALB/c, C57BL/6, CXCR2 -/-, male, wks old); reparixin is an allosteric inhibitor of CXCR1 and CXCR2.

Q2266 Park,J.G., Yoo,J.Y., Jeong,S.J., Choi,J.H., Lee,M.R., Lee,M.N., Lee,J.H., Kim,H.C., Jo,H., Yu,D.Y., Kang,S.W., Rhee,S.G., Lee,M.H., Oh,G.T. Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice. Circulation Research 2011; 109(-7-):739-U80. >>> Ebselen; DMSO; SC; Mice; 2004; ; Controls received mp w/ vehicle; animal info (8 wks old, Prdx -/-, ApoE -/-); 80% DMSO used.

Q2223 Arnold,K., Sarkar,A., Yram,M.A., Polo,J.M., Bronson,R., Sengupta,S., Seandle,M., Geijsen,N., Hochedlinger,K. Sox2(+) Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice. Cell Stem Cell 2011; 9(-4-):317-329. >>> Ganciclovir; Saline; SC; Mice; 1, 2 weeks; Animal info (Sox2-TK, wt, 3, 10-wks old); 7 or 14 day pumps used.

Q2200 Ghonem,N., Yoshida,J., Stolz,D.B., Humar,A., Starzl,T.E., Murase,N., Venkataramanan,R. Treprostinil, a Prostacyclin Analog, Ameliorates Ischemia-Reperfusion Injury in Rat Orthotopic Liver Transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2011; 11(-11-):2508-2516. >>> Treprostinil; SC; Rat; ; Animal info (male, Lewis, 200-300 g); controls received sodium citrate;.

Q2155 Zhou,J., Lee,P.L., Tsai,C.S., Lee,C.I., Yang,T.L., Chuang,H.S., Lin,W.W., Lin,T.E., Lim,S.H., Wei,S.Y., Chen,Y.L., Chien,S., Chiu,J.J. Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012; 109(-20-):7770-7775. >>> Noggin; IA (abdominal aorta); Mice; 2 weeks; Controls received mp w/ saline; animal info (ApoE -/-, C57BL/6).

Q2109 Westwell-Roper,C., Dai,D.L., Soukhatcheva,G., Potter,K.J., van Rooijen,N., Ehses,J.A., Verchere,C.B. IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction. Journal of Immunology 2011; 187(-5-):2755-2765. >>> Anakinra; Mice (NOD/SCID); 8 weeks; Controls received mp w/ saline; animal info (11 wks old, NOD/SCID); pumps replaced every 2 weeks; long-term study; immunology.

Q2106 Dilek,N., Poirier,N., Usal,C., Martinet,B., Blancho,G., Vanhove,B. Control of Transplant Tolerance and Intragraft Regulatory T Cell Localization by Myeloid-Derived Suppressor Cells and CCL5. Journal of Immunology 2012; 188(-9-):4209-4216. >>> CCL5, recomb. rat; IP; Rat; 2001; 14, 21 days; Animal info (7-9 wks old, male, Lewis, Lewis.1A, congenic); immunology.

Q2104 Rezk,B.M., Yoshida,T., Semprun-Prieto,L., Higashi,Y., Sukhanov,S., Delafontaine,P. Angiotensin II Infusion Induces Marked Diaphragmatic Skeletal Muscle Atrophy. PLoS One 2012; 7(-1-):U301-U307. >>> Angiotensin II; SC; Mice; 1 week; Controls received sham; animal info (male, FVB, 9 wks old); peptides.

Q2021 Karimi-Abdolrezaee,S., Schut,D., Wang,J., Fehlings,M.G. Chondroitinase and Growth Factors Enhance Activation and Oligodendrocyte Differentiation of Endogenous Neural Precursor Cells after Spinal Cord Injury. PLoS One 2012; 7(-5-):U605-U620. >>> Epidermal growth factor; fibroblast growth factor, basic; platelet derived growth factor-AA; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (Wistar, female, 250 g); spinal cord injury; intrathecal catheter used (0007741).

Q1934 Miyamoto,S., Shikata,K., Miyasaka,K., Okada,S., Sasaki,M., Kodera,R., Hirota,D., Kajitani,N., Takatsuka,T., Kataoka,H.U., Nishishita,S., Sato,C., Funakoshi,A., Nishimori,H., Uchida,H.A., Ogawa,D., Makino,H. Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage Anti-inflammatory Effect of Cholecystokinin. Diabetes 2012; 61(-4-):897-907. >>> Cholecystokinin octapeptide; Saline; SC; Rat; 8 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 6 wks old, STZ induced diabetes); pumps replaced after 4 weeks; peptides; cholecystokinin octapeptide also known as CCK-8S; long-term study.

Q1931 Xiao,J.T., Angsana,J., Wen,J., Smith,S.V., Park,P.W., Ford,M.L., Haller,C.A., Chaikof,E.L. Syndecan-1 Displays a Protective Role in Aortic Aneurysm Formation by Modulating T Cell-Mediated Responses. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2012; 32(-2-):386-U519. >>> Angiotensin II; SC; Mice; 2 weeks; Animal info (ApoE -/-, Sdc1 -/-); peptides; blood pressure measured via tail cuff.

Q1871 Reimers,D., Osuna,C., Gonzalo-Gobernado,R., Herranz,A.S., az-Gil,J.J., Jimenez-Escrig,A., Asensio,M.J., Miranda,C., Rodriguez-Serrano,M., Bazan,E. Liver Growth Factor Promotes the Survival of Grafted Neural Stem Cells in a Rat Model of Parkinson's Disease. CURRENT STEM CELL RESEARCH&THERAPY 2012; 7(-1-):15-25. >>> Liver growth factor; Albumin, rat; saline; CSF/CNS (striatum); Rat; 2002; 15 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, female, 225-250 g); neurodegenerative (Parkinson's disease).

Q1681 Hwang,D.H., Kim,H.M., Kang,Y.M., Joo,I.S., Cho,C.S., Yoon,B.W., Kim,S.U., Kim,B.G. Combination of Multifaceted Strategies to Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Spinal Cord Repair. CELL TRANSPLANTATION 2011; 20(-9-):1361-1379. >>> Chondroitinase ABC, protease-free; CSF/CNS (subarachnoid space, intrathecal); Rat; 2004; 28 days; Controls received mp w/ penicillinase; animal info (Sprague Dawley, female, adult, 250-300 g); pump connected to PE-10 tubing; spinal cord injury.

Q1652 Wu,J.G., Tang,H., Liu,Z.J., Ma,Z.F., Tang,A.L., Zhang,X.J., Gao,X.R., Ma,H. Angiotensin-(1-7) Inhibits Vascular Remodelling in Rat jugular Vein Grafts via Reduced ERK1/2 and p38 MAPK Activity. Journal of International Medical Research 2011; 39(-6-):2158-2168. >>> Angiotensin (1-7); IV (carotid); Rat; 2ML4; 4 weeks; Controls received mp w/ normal saline; animal info (Sprague Dawley, male, 11-12 mo old, 250-260 g); blood pressure measured via pressure transducer.

Q1527 Endtmann,C., Ebrahimian,T., Czech,T., Arfa,O., Laufs,U., Fritz,M., Wassmann,K., Werner,N., Petoumenos,V., Nickenig,G., Wassmann,S. Angiotensin II Impairs Endothelial Progenitor Cell Number and Function In Vitro and In Vivo Implications for Vascular Regeneration. Hypertension 2011; 58(-3-):394-U144. >>> Angiotensin II; SC; Mice; 12 days; Controls received mp w/ vehicle; animal info (wt, AT1 -/-); peptides.

Q1494 Uchida,H.A., Poduri,A., Subramanian,V., Cassis,L.A., Daugherty,A. Urokinase-Type Plasminogen Activator Deficiency in Bone Marrow-Derived Cells Augments Rupture of Angiotensin II-Induced Abdominal Aortic Aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-12-):2845-U251. >>> Angiotensin II; SC; Mice; 2004; 14 days; Controls received mp w/ saline; animal info (LDLr -/-, apoE -/-, uPA -/-, uPAR -/-, C57BL/6, 9-12 wks old); peptides.

Q1483 Hillmeister,P., Gatzke,N., Duelsner,A., Bader,M., Schadock,I., Hoefer,I., Hamann,I., Infante-Duarte,C., Jung,G., Troidl,K., Urban,D., Stawowy,P., Frentsch,M., Li,M.J., Nagorka,S., Wang,H.T., Shi,Y., le Noble,F., Buschmann,I. Arteriogenesis Is Modulated By Bradykinin Receptor Signaling. Circulation Research 2011; 109(-5-):524-U167. >>> R715; icatibant; SC; IP; Rat; 2004; 1007D; 3, 7, 14 days; Controls received mp w/ saline or PBS; animal info (Sprague Dawley , 330 g); R715 is a kinin receptor antagonist.

Q1419 Yu,L.Y., Hales,C.A. Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats. RESPIRATORY RESEARCH 2011; 12(-;-):U1-U11. >>> AMD 3100; SC; Rat; 14 days; Controls received mp w/ normal saline; animal info (male, Sprague-Dawley, wt, 150-200 g).

Q1416 Yong,J., Rasooly,J., Dang,H., Lu,Y.X., Middleton,B., Zhang,Z.S., Hon,L., Namavari,M., Stout,D.B., Atkinson,M.A., Tian,J.D., Gambhir,S.S., Kaufman,D.L. Multimodality Imaging of beta-Cells in Mouse Models of Type 1 and 2 Diabetes. Diabetes 2011; 60(-5-):1383-1392. >>> Ganciclovir; SC; Mice; 14 days; Animal info (C57BL/6 MIP-TF, 8 wks old).

Q1349 Tanaka,K., Yamamoto,Y., Ogino,K., Tsujimoto,S., Saito,M., Uozumi,N., Shimizu,T., Hisatome,I. Cytosolic Phospholipase A(2) alpha Contributes to Blood Pressure Increases and Endothelial Dysfunction Under Chronic NO Inhibition. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-5-):1133-U498. >>> Angiotensin II; SC; Mice; 2004; 28 days; Animal info (male, C57BL/6J, WT, 8 wks old cPLAa -/-); peptides.

Q1332 Soleimani,R., Heytens,E., Oktay,K. Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants. PLoS One 2011; 6(-4-):U2019-U2026. >>> Sphingosine-1-Phosphate; Saline; SC; Mice (SCID); 2001D; 1-4 days; 24 hours; Controls received mp w/ vehicle; animal info (SCID).

Q1316 Satoh,K., Nigro,P., Zeidan,A., Soe,N.N., Jaffre,F., Oikawa,M., O'Dell,M.R., Cui,Z.Q., Menon,P., Lu,Y., Mohan,A., Yan,C., Blaxall,B.C., Berk,B.C. Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-5-):1116-U458. >>> Angiotensin II; Saline, sterile; SC; Mice; 2004; 4 weeks; Controls received mp w/ saline; animal info (5-6 wks old, male); peptides.

Q1225 Lymperi,S., Ersek,A., Ferraro,F., Dazzi,F., Horwood,N.J. Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood 2011; 117(-5-):1540-1549. >>> Parathyroid hormone (1-34); PBS, sterile; acetic acid; SC; Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (C57BL/6, female, 8-12 wks old); functionality of mp verified by PTH 1-34 levels in the blood serum; post op. care (Baytril and Rimadyl).

Q1151 Joseph,N.M., He,S.H., Quintana,E., Kim,Y.G., Nunez,G., Morrison,S.J. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. Journal of Clinical Investigation 2011; 121(-9-):3398-3411. >>> Epidermal growth factor; fibroblast growth factor; glial-derived neurotrophic factor; BSA; PBS; IP; Rat; 7 days; Controls received mp w/ vehicle; animal info (P90).

Q1147 Jiang,X., Khan,M.A., Tian,W., Beilke,J., Natarajan,R., Kosek,J., Yoder,M.C., Semenza,G.L., Nicolls,M.R. Adenovirus-mediated HIF-1alpha gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. Journal of Clinical Investigation 2011; 121(-6-):2336-2349. >>> AMD 3100; PBS; SC; Mice; 2002; ; Controls received mp w/ saline; animal info (C57BL/6J).

Q0858 Tateno,C., Kataoka,M., Utoh,R., Tachibana,A., Itamoto,T., Asahara,T., Miya,F., Tsunoda,T., Yoshizato,K. Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver. Endocrinology 2011; 152(-4-):1479-1491. >>> Growth hormone, human; SC; Mice (transgenic/SCID); 2 weeks; Animal info (uPA/SCID, 20-30 days old, chimeric).

Q0670 Nout,Y.S., Culp,E., Schmidt,M.H., Tovar,C.A., Proeschel,C., Mayer-Proeschel,M., Noble,M.D., Beattie,M.S., Bresnahan,J.C. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Experimental Neurology 2011; 227(-1-):159-171. >>> Rolipram; DMSO; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, 71 days old); stress/adverse reaction: (increased body-weight loss, increased micturition peak frequencies) see pg. 167; spinal cord injury.

Q0668 Beguin,P.C., El-Helou,V., Gillis,M.A., Duquette,N., Gosselin,H., Brugada,R., Villeneuve,L., Lauzier,D., Tanguay,J.F., Ribuot,C., Calderone,A. Nestin((+)) Stem Cells Independently Contribute to Neural Remodelling of the Ischemic Heart. Journal of Cellular Physiology 2011; 226(-5-):1157-1165. >>> Nerve growth factor, 2.5S; SC; Rat; 2ML1; 1 week; Controls received mp w/ saline; animal info (adult, male, Sprague-Dawley).


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“In preliminary studies using this model, we observed severe side effects with 5-FU doses beyond 25 mg/kg biweekly injections (mice developed skin ulcers, bleeding and severe diarrhea). Thus, we chose to deliver 5-FU by continuous infusion at an equivalent cumulative dose in order to minimize toxicity. Additionally, studies have demonstrated an increased efficacy of chemotherapeutic agents when administered continuously.” Stoeltzing et al. Int. J. Cancer 2003;104:496-503.