References on Transplantation Research Using ALZET^® Osmotic Pumps

R0244 Gruber,S.A., Shirbacheh,M.V., Jones,J.W., Barker,J.H., Breidenbach,W.C. Local drug delivery to composite tissue allografts. MICROSURGERY 2000; 20(-8-):407-411. >>> Cyclosporin A; FK-506; IA (brachial); Rabbit; 6 days; Dose-response; review, see pg. 409.

P9167 Bretzner,F., Liu,J., Currie,E., Roskams,A.J., Tetzlaff,W. Undesired effects of a combinatorial treatment for spinal cord injury - transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus. European Journal of Neuroscience 2008; 28(-9-):1795-1807. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 300-400 g.); 28 gauge cannula, silastic tubing used; spinal cord injury; wound clips used.

P9116 Kwun,J., Hazinedaroglu,S.M., Schadde,E., Kayaoglu,H.A., Fechner,J., Hu,H.Z., Roenneburg,D., Torrealba,J., Shiao,L., Hong,X., Peng,R., Szewczyk,J.W., Sullivan,K.A., DeMartino,J., Knechtle,S.J. Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-8-):1593-1603. >>> Cyclosporin; SC; Mice; 1002; ; Animal info (male, C57BL/6, 6-8 wks old, Cxcr3-/-).

P9109 Ng,B., Kramer,E., Liebes,L., Wasserheit,C., Hochster,H., Blank,E., Ceriani,R., Furmanski,P. Radiosensitization of tumor-targeted radioimmunotherapy with prolonged topotecan infusion in human breast cancer xenografts. Cancer Res. 2001/4/1; 61(-7-):2996-3001. >>> Antibody, monoclonal, BrE3; topotecan; SC; Mice (nude); 1007D; 14 days; Controls received no treatment; dose-response (fig. 3, pg. 2999); enzyme inhibitor (topoisomerase-1); cancer (breast); animal info (athymic, female, Swiss, 8-10 wks old); BrE3 antibody is a murine IgG1 monoclonal antibody.

P9107 Shusterman,S., Grupp,S.A., Barr,R., Carpentieri,D., Zhao,H., Maris,J.M. The angiogenesis inhibitor tnp-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease. Clin.Cancer Res. 2001/4; 7(-4-):977-984. >>> TNP-470; Saline; IP; Mice (SCID); 1002; ; Controls received mp w/ vehicle; dose-response (pg 979 fig. 1b); comparison of SC injections vs. mp; half-life (p. 983) "2-6 min"; good methods pg. 978; cancer (neuroblastoma); post op. care (xylazine); animal info (4-6 wks old, athymic); 4.0 vinyl sutures used; TN-470 is an angiogenesis inhibitor; "our data demonstrate that continuous infusion of TNP-470 is feasible and that there is similar inhibition... as compared to conventional s.c. dosing." pg. 983.

P9084 Zhang,J.J., Zafrullah,M., Yang,X., Yin,X.L., Zhang,Z.G., Fuks,Z., Kolesnick,R. Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. CANCER BIOLOGY&THERAPY 2008; 7(-9-):1492-1497. >>> Oligonucleotide, antisense; PBS; SC; Mice; 5 days; Controls received mp w/ vehicle; antisense (KSR1); cancer (pancreatic).

P9073 Shu,Q., Antalffy,B., Su,J.M., Adesina,A., Ou,C.N., Pietsch,T., Blaney,S.M., Lau,C.C., Li,X.N. Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin.Cancer Res. 2006/8/1; 12(-15-):4687-4694. >>> Valproic acid; Sodium chloride; SC; Mice (SCID); 2001; 14 days; Controls received no treatment; pumps replaced after 7 days; animal info (6-10 wks old, Rag 2).

P9064 Liu,X.M., Wang,Y.W., Li,D., Ju,X.L. Transplantation of rat neural stem cells reduces stereotypic behaviors in rats after intrastriatal microinfusion of Tourette syndrome sera. Behavioural Brain Research 2008; 186(-1-):84-90. >>> Serum, human; PBS; CSF/CNS (striatum); Rat; 72 hours; Controls received mp with control serum; animal info (male, female, Wistar, 7 wks old, 260-275 g.); pumps filled with PBS, PE tube filled with 50 ul Tourette syndrome sera; pumps implanted following 1 week recovery period from guide cannula implantation; rats were allowed 1 week recovery period prior to pump implantation.

P8904 Fiorotto,M.L., Lopez,R., Oliver,W.T., Khan,A.S., Draghia-Akli,R. Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. DNA and Cell Biology 2006; 25(-8-):429-437. >>> Growth hormone-releasing hormone; radio-isotopes 125I tracer; BSA; SC; Rat (pregnant); 1003D; 52-58 hours; Controls received sham operation; functionality of mp verified by residual volume, total activity; no stress (see pg. 433); half-life (p. 432) 8 hours; teratology; peptides; animal info (female, Sprague Dawley, gd18).

P8878 Hontanilla,B., Auba,C., Gorria,O. Nerve regeneration through nerve autografts after local administration of brain-derived neurotrophic factor with osmotic pumps. Neurosurgery 2007; 61(-6-):1268-1274. >>> Brain-derived neurotrophic factor; Saline; CSF/CNS (sciatic nerve); Rat; 1002; 2 weeks; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve graft); replacement therapy (axotomy); no stress (see pg. 1270); stress/adverse reaction: (see pg. 1270) "one pump was extruded"; animal info (male, Wistar, 200-250g.); pg. 1269, fig A shows image of pump implantation and cannulae location.

P8865 Kobayashi,M., Okada,T., Murakami,T., Ozawa,K., Kobayashi,E., Morita,T. Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems. UROLOGY 2007; 70(-6-):1230-1236. >>> Ganciclovir; IP; Rat; 7 days; Gene therapy; animal info (male, ACI, 6-8 wks old).

P8782 Giraud,S., Barrou,B., Sebillaud,S., Debre,P., Klatzmann,D., Thomas-Vaslin,V. Transient depletion of dividing T lymphocytes in mice induces the emergence of regulatory T cells and dominant tolerance to islet allografts. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-5-):942-953. >>> Ganciclovir; Water, pyrogen-free; SC; Mice; mice (transgenic); 2001; 2002; 7, 14 days; STZ-induced diabetes, animal info (FVB EpCD4TK, FVB/N, B6 islet allograft, skin allograft).

P8702 Grumbles,R.M., Casella,G.T.B., Rudinsky,M.J., Wood,P.M., Sesodia,S., Bent,M., Thomas,C.K. Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. Journal of Neuroscience Research 2007; 85(-9-):1933-1942. >>> Fibroblast growth factor-6, recomb. human; PBS; BSA; IM (medial gastrocnemius); Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (female, Fischer, adult).

P8696 Babu,A.N., Murakawa,T., Thurman,J.M., Miller,E.J., Henson,P.M., Zamora,M.R., Voelkel,N.F., Nicolls,M.R. Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. Journal of Clinical Investigation 2007; 117(-12-):3774-3785. >>> Antileukinate; Saline; Hank's solution; SC; Mice; 1002; 6, 8, 10, 12, 14 days; Animal info (B6(H-2b), orthotopic tracheal transplant); CXCR2 antagonist; pulmonology.

P8634 Koyanagi,T., Noguchi,K., Ootani,A., Inagaki,K., Robbins,R.C., Mochly-Rosen,D. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):517-522. >>> Peptide, TAT (47-57); peptide TAT (47-57)-EV1-2; Saline, sterile; SC; Mice; 1002; 4 weeks; Controls received mp w/ TAT control peptide; pumps replaced after 14 days; no stress (see pg. 519); enzyme inhibitor (Epsilon PKC); cardiovascular; peptides; animal info (male, C57BL/6J (H-2b), 6-8 wks old); heterotopic cardiac transplantation.

P8504 Wilkinson,R.W., Odedra,R., Heaton,S.P., Wedge,S.R., Keen,N.J., Crafter,C., Foster,J.R., Brady,M.C., Bigley,A., Brown,E., Byth,K.F., Barrass,N.C., Mundt,K.E., Foote,K.M., Heron,N.M., Jung,F.H., Mortlock,A.A., Boyle,F.T., Green,S. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clinical Cancer Research 2007; 13(-12-):3682-3688. >>> AZD1152; SC; Mice; 2001D; 48 hours; Controls received mp w/ vehicle; dose-response (p. 3684); comparison of IV or IP injections; enzyme inhibitor (aurora B kinase); cancer; xenograft; animal info (male, 8-12 weeks old, Swiss athymic).

P8478 Ma,T., Gutnick,J., Salazar,B., Larsen,M.D., Suenaga,E., Zilber,S., Huang,Z., Huddleston,J., Smith,R.L., Goodman,S. Modulation of allograft incorporation by growth factors over a prolonged continuous infusion of duration in vivo. Bone 2007; 41(-3-):386-392. >>> Fibroblast growth factor-2; osteogenic protein-1, recomb. human; Water, distilled; acetate buffer; Bone (tibia); Rabbit; 2004; 4,36 weeks; Controls received no treatment to contralateral side; long-term study; pumps replaced every 4 weeks, with 4 week rest periods between 4 week infusion periods; animal info (New Zealand white, 6-12 months old, 3.5-4.2 kg); peptides; OP-1 also known as bone morphogenic protein-7 (BMP-7); unique drug test chamber and bone harvest chamber used in conjunction with mp.

P8394 Earle,S.A., El-Haddad,A., Patel,M.B., Ruiz,P., Pham,S.M., Majetschak,M. Prolongation of skin graft survival by exogenous ubiquitin. Transplantation 2006; 82(-11-):1544-1546. >>> Ubiquitin; albumin; Saline, normal; IP; Mice; 2002; 5,14 days; Controls received mp w/ vehicle, or albumin or no treatment; functionality of mp verified by serum ubiquitin levles; dose-response (fig. 1); no stress (see pg. 1546); immunology; peptides; animal info ( C3H/HEJ, DBA2, 22g., skin grafts); "Ubiquitin administration was well tolerated and body weight was similar in both groups" (pg. 1546).

P8367 Wranning,C.A., El-Akouri,R.R., Groth,K., Moelne,J., Parra,A.K., Braennstroem,M. Rejection of the transplanted uterus is suppressed by cyclosporine A in a semi-allogeneic mouse model. Human Reproduction 2007; 22(-2-):372-379. >>> Cyclosporin A; Propylene glycol; SC; Mice; 1007D; 7-10 days; Controls received mp w/ vehicle, or no treatment; functionality of mp verified by serum CyA levels; dose-response (Table 1); immunology; post op.care (buprenorphin, carprofen, cefuroxine); animal info (female, C57BL/6, B6CBAF1, 6-8 wks old, uterine transplant).

P8310 Singh,A.K., Gudehithlu,K.P., Litbarg,N.O., Sethupathi,P., Arruda,J.A.L., Dunea,G. Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochemical and Biophysical Research Communications 2007; 355(-1-):258-262. >>> Insulin; SC; Rat; 28 days; Replacement therapy (STZ-induced diabetes, pancreatectomy and autotransplanted into omentum; immunology; animal info (male, Sprague-Dawley, 150-200g.); nephrology.

P8295 Uesato,N., Fukui,K., Maruhashi,J., Tojo,A., Tajima,N. JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Experimental Hematology 2006; 34(-10-):1385-1392. >>> JTE-607; Cyclodextrin, 2-hydroxypropyl-beta; SC; Mice (SCID); 2001; 7 days; Controls received mp w/ vehicle; comparison of bolus injections vs. mp; cancer (leukemia); animal info (8-9 weeks old); xenograft; multiple cytokine inhibitor; antileukemic; "Administration of JTE-607 using osmotic pumps reduced the number of leukemic cells...and significantly prolonged the mouse survival..." p. 1386.

P8261 Si,Y., Ciccone,S., Yang,F.C., Yuan,J., Zeng,D., Chen,S., van de Vrugt,H.J., Critser,J., Arwert,F., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice. Blood 2006; 108(-13-):4283-4287. >>> Interferon-gamma, mouse; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; no stress (see pg. 4286); immunology; peptides; animal info (C57BL/6).

P8231 Crowley,S.D., Gurley,S.B., Herrera,M.J., Ruiz,P., Griffiths,R., Kumar,A.P., Kim,H.S., Smithies,O., Le,T.H., Coffman,T.M. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-47-):17985-17990. >>> Angiotensin II; SC; Mice; 2004; 28 days; Mean arterial pressure, mean BP taken; no stress (see pg. 17988); cardiovascular; peptides; animal info (C57BL/6, AT1A -/-, male, 2-4 months old, kidney transplantation).

P8227 Cassis,L.A., Rateri,D.L., Lu,H., Daugherty,A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007; 27(-2-):380-386. >>> Angiotensin II; Saline; Mice; 2004; 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, C57BL/6, 9 weeks old, 27 grams); bone marrow transplantation, irradiation.

P8224 Menon,J., Soto-Pantoja,D.R., Callahan,M.F., Cline,J.M., Ferrario,C.M., Tallant,E.A., Gallagher,P.E. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Research 2007; 67(-6-):2809-2815. >>> Angiotensin (1-7); Saline; heparin; IV (jugular); Mice (nude); 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 2810); cancer (lung); peptides; animal info (male, athymic, 2-4 weeks old, 15-20 grams); "During the infusion period, the animals maintained their body weight as well as food and water consumption and showed no evidence of reduced motor function. Additionally, no gross pathological abnormalities were observed in major organs..indicating a lack of toxic side effects." (p. 2810).

P8140 Husen,B., Huhtinen,K., Saloniemi,T., Messinger,J., Thole,H.H., Poutanen,M. Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts. Endocrinology 2006; 147(-11-):5333-5339. >>> B10721325; estrone; DMSO; propanediol; SC; Mice (nude); 1002; 2 weeks; Controls received mp w/ vehicle; replacement therapy (ovariectomy); dose-response (p.5335); pumps replaced after 14 days; enzyme inhibitor (hydroxysteroid 17 beta dehydrogenase 1); cancer (breast); animal info (female, BALB/cA Bom-v, Crl: nu/nu, 10-11 wks old); 50%DMSO; endocrinology.

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P8095 Ohashi,K., Kay,M.A., Yokoyama,T., Kuge,H., Kanehiro,H., Hisanaga,M., Ko,S., Nakajima,Y. Stability and repeat regeneration potential of the engineered liver tissues under the kidney capsule in mice. CELL TRANSPLANTATION 2005; 14(-9-):621-627. >>> Uridine, bromodeoxy-; Mice; 2001; 2 weeks; Animal info (FVB/N, partial hepatectomy, hepatocyte transplantation); labeling of hepatocytes.

P8084 Hirayama,S., Shiraishi,T., Shirakusa,T., Higuchi,T., Miller,E.J. Prevention of neutrophil migration ameliorates rat lung allograft rejection. MOLECULAR MEDICINE 2006; 12(-9-10-):208-213. >>> Antileukinate; PBS; IP; Rat; 2001; 7 days; Controls received mp w/ vehicle; comparison of bolus IM injection vs. mp; immunology; peptides; ischemia (lung); animal info (male, Fischer 344, 250-300g, left lung transplantation); mp primed 4 hrs in 37 celcius saline.

P8036 Yasuhara,T., Matsukawa,N., Hara,K., Yu,G.L., Xu,L., Maki,M., Kim,S.U., Borlongan,C.V. Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease. Journal of Neuroscience 2006; 26(-48-):12497-12511. >>> Stem cell factor, human recomb.; PBS; CSF/CNS (striatum); Rat; 2004; 4 weeks; Animal info (Sprague-Dawley, 200-250 grams); neurodegenerative (Parkinson's Disease); behavioral study; tissue perfusion (striatum).

P8003 Tocco,G., Illigens,B.M.W., Malfroy,B., Benichou,G. Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species. Cellular Immunology 2006; 241(-2-):59-65. >>> EUK-189; Mice; 8-10 days; Animal info (female, 6-8 weeks old, BALB/C and C57BL/6).

P7936 Bondanza,A., Valtolina,V., Magnani,Z., Ponzoni,M., Fleischhauer,K., Bonyhadi,M., Traversari,C., Sanvito,F., Toma,S., Radrizzani,M., La Seta-Catamancio,S., Ciceri,F., Bordignon,C., Bonini,C. Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes. Blood 2006; 107(-5-):1828-1836. >>> Ganciclovir; SC; Mice (SCID); 2001; 7 days; Controls received mp w/ saline; animal info (female, NOD/SCID, 6-8 weeks old, GvHD); gene therapy.

P7877 Kaneko,H., Kikuchi,K., Noguchi,J., Ozawa,M., Ohnuma,K., Maedomari,N., Kashiwazaki,N. Effects of gonadotrophin treatments on meiotic and developmental competence of oocytes in porcine primordial follicles following xenografting to nude mice. REPRODUCTION 2006; 131(-2-):279-288. >>> Follicle-stimulating hormone, porcine; Saline; SC; Mice (nude); 2004; 7, 14 days; Controls received no hormone treatment; replacement therapy (ovariectomy); dose-response (pg. 280); animal info (female, Crlj: CD1-Foxn1nu, 5-6 wk old); ovarian xenografts.

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P7791 Ulusal,B.G., Ulusal,A.E., Hung,L.M., Wei,F.C. The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: An in vivo preliminary study. Journal of Surgical Research 2006; 131(-2-):261-266. >>> CGS 21680; SC; Rat; 7 days; Controls received no treatment; no stress (see pg. 263); immunology; animal info (Brown Norway, Lewis, Hindlimb transplantation); A-2a adenosine receptor agonist; "The animals tolerated the minipumps well." (pg.263).

P7707 Fansa,H., Schneider,W., Wolf,G., Keilhoff,G. Influence of insulin-like growth factor-I (IGF-I) on nerve autografts and tissue-engineered nerve grafts. Muscle Nerve 2002/7; 26(-1-):87-93. >>> Insulin-like growth factor I; Dulbecco's mem; CSF/CNS (sciatic nerve); Rat; 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 89); animal info (female, wistar, 250-300 g).

P7675 Kinoshita,H., Kimura,O., Furukawa,T., Higuchi,K., Chujo,S., Iwai,N. Preoperative bombesin administration can protect the rat small bowel allograft from ischemic reperfusion injury. Journal of Pediatric Surgery 2005; 40(-12-):1877-1880. >>> Bombesin; SC; Rat; 2002; ; Animal info (male, Lewis, 250-300 g); neuropeptide.

P7579 Svetlecic,J., Molteni,A., Chen,Y.Y., Al-Hamed,M., Quinn,T., Herndon,B. Transplant-related bronchiolitis obliterans (BOS) demonstrates unique cytokine profiles compared to toxicant-induced BOS. Experimental and Molecular Pathology 2005; 79(-3-):198-205. >>> Papaverine HCl; CSF/CNS (intrathecal); Rat; 7, 28 days; Controls received mp w/ saline; animal info (Sprague-Dawley).

P7563 Ikegami,T., Nakamura,M., Yamane,J., Katoh,H., Okada,S., Iwanami,A., Watanabe,K., Ishii,K., Kato,F., Fujita,H., Takahashi,T., Okano,H.J., Toyama,Y., Okano,H. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-12-):3036-3046. >>> Chondroitinase ABC; Saline, physiological; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 1 week; Controls received mp w/ heat inactivated agent; stability verified by ALZAID chemical compability test kit for 7 days; animal info (adult, female, Sprague-Dawley 230-250 g); mp primed overnight in 37 C saline; spinal cord injury.

P7469 Gottmann,U., Notheisen,A., Brinkkoetter,P.T., Yard,B.A., Waldherr,R., Schnuelle,P., van der Woude,F.J., Braun,C. Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats. Transplantation 2005; 79(-10-):1344-1350. >>> Dopamine; Saline; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ vehicle; animal info (male, Lewis Fisher).

P7460 Roychowdhury,S., Blaser,B.W., Freud,A.G., Katz,K., Bhatt,D., Ferketich,A.K., Bergdall,V., Kusewitt,D., Baiocchi,R.A., Caligiuri,M.A. IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease. Blood 2005; 106(-7-):2433-2435. >>> Interleukin-15, recomb. human; interleukin-2, recomb. human; PBS; albumin, human; SC; Mice (SCID); 1007D; 10 days; Controls received mp w/ vehicle; immunology; animal info (female, CB17, hu-PBL-SCID, 8-12 weeks old).

P7417 Schmidt,N.O., Przylecki,W., Yang,W., Ziu,M., Teng,Y., Kim,S.U., Black,P.M., Aboody,K.S., Carroll,R.S. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. NEOPLASIA 2005; 7(-6-):623-629. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS (parenchyma); Mice; 2004; ; Controls received mp w/ PBS; functionality of mp verified by residual volume; cancer.

P7408 Rissler,P., Soederdahl,G., Nordman,T., Xia,L., Torndal,U.B., Bjoernstedt,M., Ericzon,B.G., Olsson,J.M., Eriksson,L.C. Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation. TRANSPLANT INTERNATIONAL 2005; 18(-8-):992-1000. >>> Uridine, bromodeoxy-; NaOH; SC; Rat; ; Labeling of hepatocytes; animal info (male, wistar-kyoto, 4-5 weeks old, 110 g).

P7321 Aparicio,T., Kotelevets,L., Tsocas,A., Laigneau,J.P., Sobhani,I., Chastre,E., Lehy,T. Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice. Gut 2005; 54(-8-):1136-1145. >>> Leptin, recomb. human; leptin, recomb. murine; Saline, BSA; SC; Mice (nude); mice; 2002; 4, 6 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma leptin levels; pumps replaced every 2 weeks; cancer (colon, intestinal adenoma); peptides.

P7167 Fujii,T., Nagaya,N., Iwase,T., Murakami,S., Miyahara,Y., Nishigami,K., Ishibashi-Ueda,H., Shirai,M., Itoh,T., Ishino,K., Sano,S., Kangawa,K., Mori,H. Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-3-):H1444-H1450. >>> Adrenomedullin, recomb.human; Glucose; saline; SC; Rat; 2004; 4 weeks; 3 days; Controls received mp w/ vehicle, cardiovascular, peptides, ischemia (cardiac), acute myocardial infarction.

P7136 Bandyopadhyay,A., Wang,L., Loepz-Casillas,F., Mendoza,V., Yeh,I.T., Sun,L.Z. Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer. PROSTATE 2005; 63(-1-):81-90. >>> Transforming growth factor-B3 receptor, recomb. soluble; PBS; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; comparison of IP injections vs. mp; no stress (see pg. 84,88); cancer (prostate); multiple pumps per animal (2).

P7081 Matsuno,A., Katayama,H., Murakami,M., Nagashima,T. In vivo growth suppression of rat C6 glioma transplanted in rat brain using antisense oligonucleotide for microtubule-associated protein 1A messenger ribonucleic acid. British Journal of Neurosurgery 2004; 18(-4-):343-346. >>> Oligodeoxynucleotide, phosphorothisate antisense; oligodeoxynucleotide, phosphorothisate sense; oligodeoxynucleotide, phosphorothisate scramble; Saline, sterile; CSF/CNS (intratumoral); Rat; 1007D; 1 week; Controls received mp w/ sense or scrambled oligos; antisense (microtubule-associated protein 1A); cancer (glioma).

P7075 Thijssen,V.L.J.L., Brandwijk,R.J.M.G., Dings,R.P.M., Griffioen,A.W. Angiogenesis gene expression profiling in xenograft models to study cellular interactions. Experimental Cell Research 2004; 299(-2-):286-293. >>> Anginex; Saline; SC; Mice (nude); 2004; 20 days; Controls received mp w/ vehicle; cancer (melanoma, ovarian carcinoma).

P7074 Robinson,G.A., Madison,R.D. Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. Vision Research 2004; 44(-23-):2667-2674. >>> Saline, normal; SC; Mice; 1007D; 7 days; Optic nerve transection and grafting to create model for retinal ganglion cell survival and axon regrowth; regeneration.

P7073 Thallinger,C., Wolschek,M.F., Maierhofer,H., Skvara,H., Pehamberger,H., Monia,B.P., Jansen,B., Wacheck,V., Selzer,E. Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of Mcl-1 antisense Oligonucleotides with low-dose cyclophosphamide. Clinical Cancer Research 2004; 10(-12-):4185-4191. >>> Oligodeoxynucleotide, phosphorothisate antisense; oligonucleotide, universal control; Saline; SC; Mice (SCID); 2002; 2 weeks; Controls received mp w/ vehicle, or UC oligo; antisense (Mcl-1); cancer (liposarcoma).

P7042 Li,X.X., Yang,Y.Z., Yuan,J., Hong,P., Freie,B., Orazi,A., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc(-/-) mice. Blood 2004; 104(-4-):1204-1209. >>> Interferon-gamma, murine; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; dose-response (fig. 7); no stress (pg. 1209); stress/adverse reaction: (see pg. 1205) "modest though not significant rise in peripheral white blood cell count" (pg. 1205); "IFN-gamma was overall well tolerated by both WT and Fancc -/- mice." (pg. 1208); hematology.

P7028 Harrington,K.J., Syrigos,K.N., Uster,P.S., Zetter,A., Lewanski,C.R., Gullick,W.J., Vile,R.G., Stewart,J.S.W. Targeted radiosensitisation by pegylated liposome-encapsulated 3', 5'-O-dipalmitoyl 5-iodo-2'-deoxyuridine in a head and neck cancer xenograft model. British Journal of Cancer 2004; 91(-2-):366-373. >>> Uridine, iododeoxy-; DMSO; water distilled; SC; Mice (nude); 2002; 7 days; Controls received PBS injections; comparison of pegylated liposomes vs. IV bolus injections vs. mp; no stress (pg. 370); cancer (head and neck); toxicology; 20% DMSO; therapeutic irradiation with 137Cs source after day 7.

P6980 Nobuhiko,A., Suganuma,E., Babaev,V.R., Fogo,A., Swift,L.L., Linton,M.F., Fazio,S., Ichikawa,I., Kon,V. Angiotensin II amplifies macrophage-driven atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004; 24(-11-):2143-2148. >>> Angiotensin II; SC; Mice; 1002; 2 weeks; Controls received mp w/ saline; functionality of mp verified by systolic blood pressure; no stress (see pg. 2144); cardiovascular; peptides; bone marrow transplantation.

P6950 Chen,W.H., Langer,R.M., Janczewska,S., Furian,L., Geary,R., Qu,X.M., Wang,M., Verani,R., Condon,T., Stecker,K., Bennett,C.F., Stepkowski,S.M. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation 2005; 79(-4-):401-408. >>> Oligonucleotide, antisense; Saline; IV; Rat; 7 days; Comparison of gavage and IV injections vs. mp; antisense (phosphorothioate/phosphodiester); transplantation; 14 d pump used; immunology.

P6949 Fowler,M., Virostko,J., Chen,Z.Y., Poffenberger,G., Radhika,A., Brissova,M., Shiota,M., Nicholson,W.E., Shi,Y.B., Hirshberg,B., Harlan,D.M., Jansen,E.D., Powers,A.C. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005; 79(-7-):768-776. >>> Insulin, human; SC; Mice (SCID); 1002; 7,10 days; Diabetes; bioluminescence imaging (BLI); IVIS 200 system used after pumps were removed.

P6927 Borgal,L., MacLeod,M., Hong,M., Lewington,M., Sadi,D., Mendez,I. Effect of local liposomal tacrolimus on cell survival and behavioural recovery following double co-grafts of VM and GDNF-C17.2 cells in the 6-OHDA rat model of Parkinson's disease. Experimental Neurology 2004; 187(-1-):225-225. >>> Rotenone; IV (jugular); Rat; 2 weeks; Neurodegenerative (Parkinson's disease).

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P6824 Day,Y.J., Huang,L., McDuffie,M.J., Rosin,D.L., Ye,H., Chen,J.F., Schwarzschild,M.A., Fink,J.S., Linden,J., Okusa,M.D. Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells. J.Clin.Invest 2003/9; 112(-6-):883-891. >>> ATL146e; rolipram; DMSO; PBS; SC; Mice; 1003D; 29 hours; Controls received mp w/ vehicle; enzyme inhibitor (phospodiesterase IV); cardiovascular; ischemia; 0.01% DMSO; chimeric mice obtained via bone marrow transplantation.

P6814 Wang,Q.C., Horiatis,D., Pinski,J. Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation. International Journal of Cancer 2004; 111(-4-):508-513. >>> Interleukin-6; SC; Mice (nude); 3 weeks; Controls received SC saline injections; comparison of SC injections vs. mp; no stress (see pg. 511); cancer (prostate).

P6806 Haninec,P., Dubovy,P., Samal,F., Houstava,L., Stejskal,L. Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots: a comparison of intrathecal administration of brain-derived neurotrophic factor and Cerebrolysin. Experimental Brain Research 2004; 159(-4-):425-432. >>> Brain-derived neurotrophic factor; cerebrolysin; PBS; CSF/CNS (intrathecal); Rat; 2002; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; ALZET brain infusion kit 2 used; C5 ventral root avulsion; "indicating a superior availability and effect of neuron-promoting agents after their continuous intrathecal rather than single or intravenous administration even if their concentrations were lower." (p. 430).

P6790 Seo,Y., Yan,T., Schupp,J.E., Colussi,V., Taylor,K.L., Kinsella,T.J. Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2-deoxyribose. Clinical Cancer Research 2004; 10(-22-):7520-7528. >>> Uridine, iododeoxy; NaOH; SC; Mice (nude); 2001; 7 days; Comparison of oral IPdR vs. mp; cancer (colon); athymic; "the use of oral IPdR results in dramatically higher but transient plasma IUdR levels in comparison with continuous infusion IUdR." (p. 7523).

P6785 Luckow,B., Joergensen,J., Chilla,S., Li,J.P., Henger,A., Kiss,E., Wieczorek,G., Roth,L., Hartmann,N., Hoffmann,R., Kretzler,M., Nelson,P.J., de Lema,G.P., Maier,H., Wurst,W., Balling,R., Pfeffer,K., Groene,H.J., Schloendorff,D., Zerwes,H.G. Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. European Journal of Immunology 2004; 34(-9-):2568-2578. >>> Cyclosporin A; SC; Mice; 2002; ; Heart transplant; cardiovascular.

P6646 Aharinejad,S., Paulus,P., Sioud,M., Hofmann,M., Zins,K., Schaefer,R., Stanley,E.R., Abraham,D., Aharinejad,S. Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Research 2004; 64(--):5378-5384. >>> Oligonucleotide, antisense; oligonucleotide, scrambled; Ringer's solution; SC; Mice (nude); 1002; 14 days; Controls received mp w/ vehicle; antisense (CSF)-1; cancer (carcinoma, breast); transplantation.

P6538 Grimpe,B., Silver,J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. Journal of Neuroscience 2004; 24(-6-):1393-1397. >>> Oligodeoxyribonucleotide, phosphorothioated; CSF/CNS (intrathecal, subarachnoid space); Mice; 1007D; 7 days; Controls received mp w/ control DNA enzyme; antisense (xylosyltransferase-1); spinal cord injury; PE-60 tubing connected to PE-10 tubing for IT delivery; DNA enzyme against xylosyltransferase-1 (XT-1).

P6535 Fischer,W., Gustafsson,L., Mossberg,A.K., Gronli,J., Mork,S., Bjerkvig,R., Svanborg,C. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Research 2004; 64(-6-):2105-2112. >>> Lactalbumin, alpha; HAMLET; radio-isotopes; 125I tracer; saline; CSF/CNS (intratumoral); Rat (nude); 2001D; 1 day; Tissue perfusion (tumor); functionality of mp verified by autoradiography on brain sections; no stress (see pg. 2108); cancer (glioblastoma); brain tissue distribution; agent is called HAMLET or (human alpha lact albumin made lethal to tumor cells); "...there were no signs of edema or tissue damage in the surrounding brain, including the cortex, which had been penetrated by the [26 gauge] infusion cannula." p. 2108.

P6497 Tejeda,M., Gaal,D., Barna,K., Csuka,O., Keri,G. The antitumor activity of the somatostatin structural derivative (TT-232) on different human tumor xenografts. Anticancer Research 2003; 23(-5A-):4061-4066. >>> TT-232; Acetic acid; sodium acetate; water, distilled; mannitol; SC; Mice; 2002; 14,28 days; Dose-response (fig.2); comparison of daily SC injections vs. mp; pumps replaced at day 14; stability verified over 3 weeks; cancer (prostate, breast, colon, melanoma, leukemia); peptides; "a significant antitumor activity of TT-232 was observed following long-term infusion using osmotic minipumps" (p. 4064).

P6352 Akhtar,N., Padilla,M.L., Dickerson,E.B., Steinberg,H., Breen,M., Auerbach,R., Helfand,S.C. Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft model. NEOPLASIA 2004; 6(-2-):106-116. >>> Interleukin-12; PBS; SC; Mice (SCID); 2004; 1 week; Controls received mp w/ vehicle; functionality of mp verified by pump explantation, examination and tumor reduction; cancer (Hemangiosarcoma); peptides; pump model not listed; tumor cells from a canine.

P6344 El-Salhy,M., Dennerqvist,V. Effects of triple therapy with octreotide, galanin and serotonin on liver metastasis of human colon cancer in xenografts. Oncology Reports 2004; 11(--):1177-1182. >>> Octreotide; galanin; serotonin; Saline; IP; Mice (nude); 1002; 14 days; Controls received mp w/ vehicle; no stress (pg. 1179); cancer (colon).

P6311 Coumans,J.V., Lin,T.T-S., Dai,H.N., Macarthur,L., McAtee,M., Nash,C., Bregman,B.S. Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotropins. The Journal of Neuroscience 2001; 21(-23-):9334-9344. >>> Brain-derived neurotrophic factor, human recomb.; NT-3, human recomb.; CSF/CNS (spinal cord, intrathecal); Rat; 2002; 14 days; Controls received mp w/ saline; tissue perfusion (fetal spinal cord transplant tissue); good methods p.9335; post op. care (sulfamethoxazole-trimethoprim).

P6267 Ader,I., Delmas,C., Bonnet,J., Rochaix,P., Favre,G., Toulas,C., Cohen-Jonathan-Moyal,E. Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts. ONCOGENE 2003; 22(-55-):8861-8869. >>> Dexamethasone; SC; 6 days; Cancer (glioblastoma); transplantation; pump and animal model not listed.

P6266 Harper,J.M., Krishnan,C., Darman,J.S., Deshpande,D.M., Peck,S., Shats,I., Backovic,S., Rothstein,J.D., Kerr,D.A. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-18-):7123-7128. >>> PBS; Y-27632; dcbAMP; CSF; CSF/CNS (intrathecal, lumbar); Rat; 1007D; 7 days; Transplantation of cells.

P6265 Tepel,J., Kruse,M.L., March,C., Fiedler,A., Kapischke,M., Ketterer,T., Sipos,B., Kremer,B., Kalthoff,H. Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: A novel adjuvant treatment strategy for pancreatic ductal carcinoma. Pancreas 2004; 28(-1-):1-12. >>> Oligodeoxynucleotide, antisense; SC; Mice (SCID); 14 days; Tissue perfusion (intratumoral); comparison of IP injections vs. sc mp; cancer (pancreatic ductal carcinoma); transplantation; 200 ul pump used.

P6261 Nikulina,E., Tidwell,J.L., Dai,H.N., Bregman,B.S., Filbin,M.T. The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-23-):8786-8790. >>> Rolipram; Saline; DMSO; SC; Rat; 1,2,3,10 days; Controls received mp w/ vehicle; dose-response (p. 8788, Fig 2A); 50% DMSO used in the 1,2,&3 day study; 16% used in the 10 day study; no pump model listed; transplantation.

P6244 Furukawa,T., Kimura,O., Go,S., Iwai,N. Small bowel allografts maintained by administration of bombesin while under immunosuppression. Journal of Pediatric Surgery 2003; 38(-1-):83-86. >>> Bombesin; IP; Rat; 2002; 2 weeks; Controls received mp w/ saline; no stress (see pg. 84); immunology; peptides.

P6216 Suzuki,Y., Ishibiki,Y., Kawai,K., Sasaki,M., Matsuda,M., Watanabe,T., Shirasaka,T., Kamano,T. Effect of combination of TS-1 and low-dose cisplatin on sarcoma-180 mouse sarcoma. Anti-cancer Drugs 2003; 14(-6-):475-479. >>> Fluorouracil, 5-; IP; Mice; 1007D; 5 days; Controls received no treatment; cancer (sarcoma); transplantation.

P6187 Abraham,D., Abri,S., Hofmann,M., Hoeltl,W., Aharinejad,S. Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts. Journal of Urology 2003; 170(-4-):1388-1393. >>> Thrombospondin-1; endostatin, recomb. mouse; Ringer's solution; SC; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; cancer (testicular); thrombospondin-1 is also known as tsp-1.

P6178 Swiercz,R, Keck,R.W, Skrzypcak-Jankun,E, Selman,S.H, Jankun,J  Oncology Reports 2001; 8(--):463-470. >>> Plasminogen activator inhibitor-1; Saline; SC; Mice (SCID); 2004; 28 days; Controls received mp w/ saline; dose-response (fig. 4 and 5); cancer (prostate); angiogenesis inhibitor.

P6171 Nikolovski,Z., Hof,A., Baumlin,Y., Hof,R.P. Efficacy of SDZ RAD compared with CsA monotherapy and combined RAD/FTY720 treatment in a murine cardiac allotransplantation model. TRANSPLANT IMMUNOLOGY 2001; 9(--):43-49. >>> SDZ RAD; cyclosporin A; Propanediol propylene glycol, 1,2-; SC; Mice; 2002; 8 weeks; Controls received mp w/ vehicle; pumps replaced every two weeks; cardiovascular; SDZ RAD (everolimus or certican) is an immunosuppresant; "SDZ RAD has a shorter half-life than rapamycin; CsA was dissolved in sandimmune IV solution.

P6167 Matsumoto,Y., Hof,A., Baumlin,Y., Hof,R.P. Efficacy of mycophenolate sodium as monotherapy and in combination wit h FTY720 in a DA-to-Lewis-rat heart-transplantation model. Transplantation 2002; 74(-10-):1372-1376. >>> Mycophenolate sodium; Propylene glycol; water, pyrogen free; SC; Rat; 2ML2; 4 weeks; Controls received mp w/ vehicle; dose-response (p. 1374); pumps replaced once; enzyme inhibitor (inosine monophosphate dehydrogenase); immunology; 90% propylene glycol used; transplantation.

P6157 Gysemans,C., Stoffels,K., Giulietti,A., Overbergh,L., Waer,M., Lannoo,M., Feige,U., Mathieu,C. Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents. Diabetologia 2003; 46(-8-):1115-1123. >>> Interleukin-1 receptor antagonist; SC; Mice (NOD); .

P5997 Kuroiwa,M., Takeuchi,T., Lee,J.H., Yoshizawa,J., Hirato,J., Kaneko,S., Choi,S.H., Suzuki,N., Ikeda,H., Tsuchida,Y. Continuous versus intermittent administration of human endostatin in xenografted human neuroblastoma. Journal of Pediatric Surgery 2003; 38(-10-):1499-1505. >>> Endostatin, recomb. human; Saline; SC; Mice (nude); 1003D; 3 days; Controls received 3 mp w/ vehicle; comparison of SC injections vs. mp; no stress (see p. 1501); cancer (neuroblastoma); angiogenesis inhibitor; multiple pumps per animal (3); picture of nude mouse w/3 pumps (fig.1; p. 1500); "The set of 3 osmotic pumps was retained successfully in the subcutaneous tissue of the treated and control animals throughout the experiment, no decrease in body weight was observed in either group." (p. 1501).

P5927 Shao,T.C., Li,H.L., Eid,W., Ittmann,M., Unni,E., Cunningham,G.R. In vivo preservation of steroid specificity in CWR22 xenografts having a mutated androgen receptor. PROSTATE 2003; 57(-1-):1-7. >>> Testosterone; estradiol; progesterone; flutamide; Cylodextrin, 2-beta-hydroxypropl; SC; Mice (nude); 2004; 4 weeks; Replacement therapy (castration); cancer (prostate); CWR22 xenograft used; flutamide is an anti-androgen; animal info (5-6 week old, nude ,ORX).

P5887 Matsumoto,Y., Hof,A., Baumlin,Y., Hof,R.P. Differential effect of cyclosporine A and SDZ RAD on neointima formation of carotid allografts in apolipoprotein E-deficient mice. Transplantation 2003; 76(-8-):1166-1170. >>> SDZ RAD; cyclosporin A; Propylene glycol; SC; Mice (knockout); 2002; 8 weeks; Dose-response (survival dose response) p. 1168; pumps replaced every 2 weeks; immunology; (RAD) is a novel rapamycin derivative and is an immunosuppresant, aka everolimus or certican; sandimmun IV solution used; "CSA&RAD were administered by ALZET minipumps, which we prefer because of the well-defined drug exposure." p. 1168.

P5835 Svechnikova,I., Gray,S.G., Kundrotiene,J., Ponthan,F., Kogner,P., Ekstrom,T.J. Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate. INTERNATIONAL JOURNAL OF ONCOLOGY 2003; 22(-3-):579-588. >>> EB 1089; Disodium phosphate dihydrate; phosphate dihydrate; solutol HS-15; sodium chloride; sodium dihydrate; sodium; SC; Mice (nude); 1002; 7 days; Controls received mp w/ vehicle; cancer (breast); EB 1089 is a vitamin D analog; also called seocalcitol.

P5613 Chen,H.C., Jensen,D.R., Myers,H.M., Eckel,R.H., Farese,RV Jr  Journal of Clinical Investigation 2003; 111(-11-):1715-1722. >>> Leptin; SC; mice; 2001; 5 days; Controls received mp with saline; replacement therapy (genetically leptin deficient mice); pumps replaced after 7 days; peptides.

P5542 Fernandez-Botran,R., Gorantla,V., Sun,X.C., Ren,X.P., Perez-Abadia,G., Crespo,F.A., Oliver,R., Orhun,H.I., Quan,E.E., Maldonado,C., Ray,M., Barker,J.H. Targeting of glycosaminoglycan-cytokine interactions as a novel therapeutic approach in allotransplantation. Transplantation 2002; 74(-5-):623-629. >>> MC-2; Saline; IA (profunda femoris artery); Rat; 2ML2; ; Controls received mp w/ vehicle; tissue perfusion (skin flap allograft); immunology; peptides; MC-2 is derived from mouse interferon gamma; transplant.

P5525 Bickerstaff,A., Orosz,C. Evidence for a limited contribution of immune regulation to cardiac allograft acceptance. Human Immunology 2002; 63(-10-):935-947. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5524 Bickerstaff,A.A., Wang,J.J., Xia,D.Y., Orosz,C.G. Allograft acceptance despite differential strain-specific induction of TGF-beta/IL-10-mediated immunoregulation. AMERICAN JOURNAL OF TRANSPLANTATION 2002; 2(-9-):819-827. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5522 Bumgardner,G.L., Gao,D.H., Li,J.S., Bickerstaff,A., Orosz,C.G. MHC-identical heart and hepatocyte allografts evoke opposite immune responses within the same host. Transplantation 2002; 74(-6-):855-864. >>> Gallium nitrate; SC; Mice; 2002; 28 days; Immunology; transplantation.

P5518 Bickerstaff,A.A., Wang,J.J., Pelletier,R.P., Orosz,C.G. The graft helps to define the character of the alloimmune response. TRANSPLANT IMMUNOLOGY 2002; 9(-2-4-):137-141. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5505 Aharinejad,S., Abraham,D., Paulus,P., Abri,H., Hofmann,M., Grossschmidt,K., Schafer,R., Stanley,E.R., Hofbauer,R. Colony-stimulating factor-1 antisense treatment suppresses growth of human tumor xenografts in mice. Cancer Research 2002; 62(-18-):5317-5324. >>> Oligonucleotide, sense; oligonucleotide, antisense; SC; Mice (scid); mice (nude); 1002; 14 days; Controls received mp w/ Ringer's; cancer; antisense.

P5471 Inuzuka,S., Koga,S., Nishikido,M., Miyata,Y., Kanda,S., Shimokawa,I., Tanaka,M., Saito,Y., Kanetake,H. Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E-2. Immunology Letters 2002; 83(-2-):119-124. >>> Aminoguanidine; Saline; IV (jugular); Rat; ; Aminoguanidine is an inhibitor of inducible nitric oxide synthase.

P5463 O'Connor,T.P., Liesen,D.A., Mann,P.C., Rolando,L., Banz,W.J. A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts. Journal of Nutrition 2002; 132(-8-):2283-2287. >>> Interleukin-13 endotoxin; PBS; IP; Mice (nude); 14 days; Comparison of IV injections vs mp; cancer (head and neck); IL-13 endotoxin, also called IL13-PE38QQR, is composed of IL-13 and a mutated form of a Pseudomonas endotoxin; compared to IV injections, continuous infusion decreased the toxicity and increased the efficacy of IL-13 cytotoxin.

P5317 Renkonen,R., Fukuda,M.N., Petrov,L., Paavonen,T., Renkonen,J., Hayry,P., Fukuda,M. A peptide mimic of selectin ligands abolishes in vivo inflammation but has no effect on the rat heart allograft survival. Transplantation 2002; 74(-1-):2-6. >>> Selectin binding peptide; BSA; IP; Rat; ; Controls received mp w/ vehicle; comparison of 2x daily IV injections vs. mp; immunology; peptides; transplantation; IELLPAR peptide inhibits E-, P-, and L-selectin adhesion.

P5270 Suga,M., Maclean,A.A., Keshavjee,S., Fischer,S., Moreira,J.M., Liu,M. RANTES plays an important role in the evolution of allograft transplant- induced fibrous airway obliteration. Am.J Respir.Crit Care Med. 2000/11; 162(-5-):1940-1948. >>> Antibody, polyclonal anti-rat RANTES; Immunoglobulin G, rabbit; RANTES; Saline; PBS; BSA; Tracheal graft; Rat; 1007D; 2002;; 7, 14, 24 days; Controls received mp w/ vehicle; pumps replaced after 14 days; 14-day stability verified by RANTES ELISA (p.1944); Immunology; peptides; transplantation; RANTES is a chemokine; concentration of RANTES in mp measured before and after delivery (p.1945).

P5248 Wongtrakul,S., Bishop,A.T., Friedrich,P.F. Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts. J Hand Surg.[Am.] 2002/3; 27(-2-):277-285. >>> Vascular endothelial growth factor; PBS; Albumin, rabbit serum; CSF/CNS (sciatic nerve); Rabbit; 1003D; 3 days; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve graft); peptides; human recomb. VEGF used; transplantation;.

P5101 Simonson,M.S., Robinson,A.V., Schulak,J.A., Hricik,D.E. Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine. Transplantation 2002; 73(-7-):1054-1059. >>> Phosphoramidon; Water; SC; rat; 2ML4; up to 52 days; controls received mp w/ vehicle; pumps replaced after 28 days; immunology; transplantation research; phosphoramidon is an endothelin-converting enzyme inhibitor; animals with allografts surviving longer than 28 days received a fresh pump.

P5086 Hirotani,H., Ohtsuka-Isoya,M., Mori,S., Sakai,R., Eto,Y., Echigo,S., Shinoda,H. Activin A Increases the Bone Mass of Grafted Bone in C3H/HeJ Mice. Calcif.Tissue Int. 2002/4; 70(--):330-338. >>> Activin A; Saline; Bone (tibia graft); mice; 2001; 2002; 2004; 1, 2, or 4 weeks; controls received mp w/ vehicle; tissue perfusion (tibial bone graft); graphic of pump setup (p. 331); Activin A was recombinant human; multiple pumps per animal (2): one containing Activin, one containing saline (control).

P5074 Kown,M.H., van der Steenhoven,T.J., Jahncke,C.L., Mari,C., Lijkwan,M.A., Koransky,M.L., Blankenberg,F.G., Strauss,H.W., Robbins,R.C. Zinc chloride-mediated reduction of apoptosis as an adjunct immunosuppressive modality in cardiac transplantation. J Heart Lung Transplant 2002/3; 21(-3-):360-365. >>> Zinc chloride; SC; rat; 14 days; immunology; 14-day pump used, model not specified; transplantation research.

P5030 Kisker,O., Becker,C.M., Prox,D., Fannon,M., D'Amato,R., Flynn,E., Fogler,W.E., Sim,B.K., Allred,E.N., Pirie-Shepherd,S.R., Folkman,J. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model. Cancer Res 2001/10/15; 61(-20-):7669-7674. >>> Endostatin; Sodium citrate; Sodium phosphate; IP; mice (SCID); mice; 2001; 14, 24, 32 days; controls received mp w/ vehicle; functionality of mp verified by serum endostatin levels; dose-response (p.7673, Fig. 4); comparison of SC and IP bolus injections vs. continuous infusion w/ mp; pumps replaced every 7 days; endostatin stability verified by in vitro biologic activity after 1-7 day implantation; half-life (p. 7669) of endostation in mice after SC bolus is ~10 hrs.; cancer; angiogenesis inhibitor; recomb. human endostatin used; continuous administration of human endostatin resulted in increased efficacy and an 8-10-fold decrease in dose required to achieve the same effect as daily bolus administration.

P4864 Xia,D.Y., Sanders,A., Shah,M., Bickerstaff,A., Orosz,C. Real-time polymerase chain reaction analysis reveals an evolution of cytokine mRNA production in allograft acceptor mice. Transplantation 2001; 72(-5-):907-914. >>> Gallium nitrate; SC; mice; 2002; 28 days; functionality of mp verified by plasma gallium nitrate levels; pumps replaced after 14 days; immunology; gallium nitrate is an immunosuppressant..

P4854 Zhang,J.L., Yamaguchi,Y., Mori,K., Okabe,K., Hidaka,H., Ohshiro,H., Uchino,S., Ishihara,K., Furuhashi,T., Yamada,S., Ogawa,M. A serine protease inhibitor, N-alpha-tosyl-L-lysine chloromethyl ketone, prolongs rat hepatic allograft survival. Journal of Surgical Research 2001; 96(--):296-303. >>> Lysine chloromethyl ketone, N-a-tosyl-L-; Saline; SC; rat; up to 7 days; controls received mp w/ vehicle; immunology; enzyme inhibitor; TLCK is a serine protease inhibitor; immunosuppression..

P4655 Cohen-Jonathan,E, Muschel,R.J, McKenna,W.G, Evans,S.M, Cerniglia,G, Mick,R, Kusewitt,D, Sebti,S.M, Hamilton,A.D, Oliff,A, Kohl,N, Gibbs,J.B, Bernhard,E.J  Radiat.Res. 2000; 154(--):125-132. >>> L-744,832;; DMSO; Water;; SC;; mice (nude);; 3-7 days;; Controls received mp w/ vehicle; cancer; enzyme inhibitor; 50% DMSO used; L-744,832 is a Farnesyltransferase inhibitor.

P4512 Thomas-Vaslin,V, Bellier,B, Cohen,J.L, Boyer,O, Raynal-Raschilas,N, Glotz,Denis, Klatzmann,D  Transplantation 2000/5/27; 69(-10-):2154-2161. >>> Ganciclovir;; Water;; SC;; mice (transgenic);; 2001; 2002;; 7, 14 days;; funtionality of mp verified by ganciclovir plasma levels by liquid chromatography; immunology; transplantation;.

P4484 Abdaimi,K.E, Dion,N, Papavasiliou,V, Cardinal,P-E, Binderup,L, Goltzman,D, Ste-Marie,L-G, Kremer,R  Cancer Research 2000/8/15; 60(--):4412-4418. >>> EB 1089; Propylene glycol; ethanol; saline; SC; Mice (nude); 2004; 4 weeks; Controls received mp w/vehicle; cancer; transplantation; EB 1089 is a vitamin D analog; pump model incorrectly stated as 2ML4.