References on the Intratumoral Administration of Agents Using ALZET^® Osmotic Pumps

R0088 Harbaugh,R.E., Saunders,R.L., Reeder,R.F. Use of implantable pumps for central nervous system drug infusions to treat neurological disease. Neurosurgery 1988; 23(--):693-698. >>> Cisplatin; CSF/CNS (intratumoral); human; rat; 2001; 2002; no duration posted; tissue perfusion (tumor); cancer/immunology.

P9057 Masunaga,S., Sakurai,Y., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Nagasawa,H., Uto,Y., Hori,H., Ono,K. The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons. British Journal of Radiology 2006; 79(-948-):991-998. >>> Uridine, bromodeoxy-; tirapazamine; Saline; SC; Mice; 2001D; 5 days; 24 hours; Tissue perfusion (tumor); comparison of IP injections vs. mp; cancer; animal info (8-11 wks old, female, syngenic C3H, He); tirapazamine, also known as TP2, is a lead compound as a bioreactive hypoxic cytotoxin; labing of P cells; cancer.

P8729 Masunaga,S., Takahashi,A., Ohnishi,K., Nagata,K., Suzuki,M., Kashino,G., Kinashi,Y., Ohnishi,T., Ono,K. Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. Oncology Reports 2007; 18(-6-):1589-1596. >>> Uridine, bromodeoxy-; Saline; SC; Mice (nude); 2001; 7 days; Tissue perfusion (tumor); cancer; animal info (Balb/cA, nude); labeling of tumor cells.

P8366 Dorrell,M.I., Aguilar,E., Scheppke,L., Barnett,F.H., Friedlander,M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-3-):967-972. >>> Vascular endothelial growth factor, aptamer; EMD472523; T2-TrpRS; PBS; CSF/CNS (intratumoral); Rat; 2001D; 2ML2; 2ML4; 3,6 days; 24 hours; Controls received mp w/ vehicle; cancer (gliosarcoma); animal info (male, Fischer, 344); EMD472523 is an integrin antagonist, VEGF aptamer is chemically identical to Macugen; T2 is a proteolytic fragment of tryptophan tRNA synthetase; all agents have angiostatic activity; tissue perfusion (tumor).

P8287 Manabe,T., Okino,H., Maeyama,R., Mizumoto,K., Tanaka,M., Matsuda,T. New infusion device for trans-tissue, sustained local delivery of anticancer agent to surgically resected tissue: Potential use for suppression of local recurrence of pancreatic cancer. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2005; 73B(-1-):203-207. >>> Gemcitabine; SC; Mice (nude); 1007D; 7 days; Tissue perfusion (intratumoral); comparison of IP injections; cancer (pancreatic); animal info (five week old); pump used as part of a novel infusion device; pictures of device p. 205; PE tubing used to connect pump to perfusion device; continuous infusion resulted in macroscopically undetectable tumors after day 6.

P8208 Martens,T., Schmidt,N.O., Eckerich,C., Fillbrandt,R., Merchant,M., Schwall,R., Westphal,M., Lamszus,K. A novel one-armed anti-c-met antibody inhibits glioblastoma growth in vivo. Clinical Cancer Research 2006; 12(-20-):6144-6152. >>> Antibody, anti-c-Met, OA5D5; Histidine; CSF/CNS (intratumoral); Mice (nude); 2004; 12, 21, 28 days; Controls received mp w/ vehicle; cancer (glioblastoma); ALZET brain infusion kit 2 used; animal info (male, NMRI-nu/nu, 6-8 wks old); "Because the OA-5D5 antibody is a relatively large but stable molecule, convection-enhanced drug delivery (by mp) was ideally suited to deliver it in our orthotopic model." (p.6151); tissue perfusion (tumor).

P8145 Grommes,C., Landreth,G.E., Sastre,M., Beck,M., Feinstein,D.L., Jacobs,A.H., Schlegel,U., Heneka,M.T. Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment. MOLECULAR PHARMACOLOGY 2006; 70(-5-):1524-1533. >>> Pioglitazone; DMSO; PBS; CSF/CNS (intratumoral); Rat; 2ML4; 3, 6, 9, 14, 21 days; Controls received mp w/ vehicle; comparison of oral admin. vs. mp; no stress (see p.1532); stability verified by in vitro incubation at 37 celsius for 21 days; cancer (glioma); ALZET brain infusion kit used; animal info (Sprague-Dawley, 200-250g.); 0.1% DMSO; Antineoplastic; tissue perfusion (tumor).

P7975 Pyrko,P., Wang,W., Markland,F.S., Swenson,S.D., Schmitmeier,S., Schonthal,A.H., Chen,T.C. The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model. Journal of Neurosurgery 2005; 103(-3-):526-. >>> Contortrostatin; CSF/CNS (intratumorally); Mice; 2 weeks; Controls received mp w/ PBS; plasma levels taken; cancer (glioma); brain tissue distribution; snake venom disintegrin; "agent was well tolerated by animals and lacks obvious neurotoxic side effects. All the contortrostatin treated mice survived the entire treatment period and continued to do well for seven more days after the termination." p. 533; tygon tubing used; tissue perfusion (tumor).

P7905 Shir,A., Ogris,M., Wagner,E., Levitzki,A. EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLOS MEDICINE 2006; 3(-1-):125-135. >>> RNA, double stranded; polyinosine-cytosine (poly IC) dsRNA; Non-viral vector; SC; Mice; 2001D; 2 days; Per communication with author on 8/11/07, "We did not have any particular problems with the anesthesia exposure. For the pump replacement procedure Ketamine/Xylazine 2% (0.85ml/0.15ml), 40-50 ul IP per mouse (25 gram) was used. Replacing of the pump was not problematic either. The skin was closed with a surgical clips which are less traumatic to the mice and are easily applied and removed." 2001D pump replaced every day for two days total duration; synthetic dsRNA was attached to a non-viral vector (PEI-PEG-EGF beta PEI-Mel complexes) with specificity to the epidermal growth factor receptor (EGFR); controls received vector only (no poly IC); tissue perfusion (intratumoral); cancer (glioblastoma, breast, adenocarcinoma).

P7197 MacKay,J.A., Deen,D.F., Szoka,FC Jr  Brain Research 2005; 1035(-2-):139-153. >>> Liposomes; FITC-dextran-lysine; Saline; tris buffer; CSF/CNS (caudate putamen); CSF/CNS (intratumoral); Rat; 2001D; 24 hours; Tissue perfusion (intratumoral); comparison of acute CSF/CNS injection vs. mp; half-life (p. 151) 9.9 hours; cancer (glioblastoma); ALZET brian infusion kit 2 used; brain tissue distribution; post op. care (buprenophine).

P6764 Frewert,S., Stockhammer,F., Warschewske,G., Zenclussen,A.C., Rupprecht,S., Volk,H.D., Woiciechowsky,C. Intratumoral infusion of interleukin-1 beta and interferon-gamma; induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neuroscience Letters 2004; 364(-3-):145-148. >>> Interleukin-1, beta recomb. rat; Interferon-gamma, recomb. rat; Saline, physiological; albumin, human serum; CSF/CNS (intratumoral); Rat; 1003D; 48 hours; Controls received mp w/ vehicle; tissue perfusion (tumor); cancer (glioma).

P6720 Gondi,C.S., Lakka,S.S., Dinh,D.H., Olivero,W.C., Gujrati,M., Rao,J.S., Rao,J.S. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. ONCOGENE 2004; 23(--):8486-8496. >>> RNA, small interfering; EV/SV vector; PBS; CSF/CNS (intratumoral); Mice (nude); ; Controls received mp w/ vehicle; tissue perfusion (tumor); cancer (glioma); gene therapy; antiangiogenesis; siRNA (cathepsin B); pump model not stated (0.25 ul/hr); "...local intracranial delivery of pcu using mini-osmotic pumps effectively inhibited human malignant glioma growth.".

P6540 Grossi,P.M., Ochiai,H., Archer,G.E., McLendon,R.E., Zalutsky,M.R., Friedman,A.H., Friedman,H.S., Bigner,D.D., Sampson,J.H. Efficacy of intracerebral microinfusion of trastuzumab in an Athymic rat model of intracerebral metastatic breast cancer. Clinical Cancer Research 2003; 9(-15-):5514-5520. >>> Herceptin; antibody, anti-Her2 monoclonal; radio-isotopes; Saline; 125I tracer; IP; CSF/CNS (intratumoral); Rat (athymic); 2ML1; 7 days; Tissue perfusion (tumor); herceptin serum levels (p. 5516); comparison of systemic IP mp vs. intracerebral mp infusion; cancer (breast); brain tissue distribution; radiolabeled herceptin (transtuzumab) was also infused intratumorally, peritumorally, and i.p to study tissue distribution.

P6535 Fischer,W., Gustafsson,L., Mossberg,A.K., Gronli,J., Mork,S., Bjerkvig,R., Svanborg,C. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Research 2004; 64(-6-):2105-2112. >>> Lactalbumin, alpha; HAMLET; radio-isotopes; 125I tracer; saline; CSF/CNS (intratumoral); Rat (nude); 2001D; 1 day; Tissue perfusion (tumor); functionality of mp verified by autoradiography on brain sections; no stress (see pg. 2108); cancer (glioblastoma); brain tissue distribution; agent is called HAMLET or (human alpha lact albumin made lethal to tumor cells); "...there were no signs of edema or tissue damage in the surrounding brain, including the cortex, which had been penetrated by the [26 gauge] infusion cannula." p. 2108.

P6373 Souweidane,M.M., Occhiogrosso,G., Mark,E.B., Edgar,M.A. Interstitial infusion of IL13-PE38QQR in the rat brain stem. Journal of Neuro-oncology 2004; 67(-3-):287-293. >>> Interleukin-13,PE38QQR; Saline; serum albumin; CSF/CNS (brain stem); Rat; 2001D; 24 hours; Tissue perfusion (brain stem); stability verified (7 days at 37 degrees Celsius); good methods p. 288; cancer; cyanoacrylate adhesive; pump incorrectly labeled as a 2001; IL13-PE38QQR is a tumor specific, chimeric cytotoxin; 30 g Plastics One Cannula used; vinyl catheter tubing from DURECT used.

P6265 Tepel,J., Kruse,M.L., March,C., Fiedler,A., Kapischke,M., Ketterer,T., Sipos,B., Kremer,B., Kalthoff,H. Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: A novel adjuvant treatment strategy for pancreatic ductal carcinoma. Pancreas 2004; 28(-1-):1-12. >>> Oligodeoxynucleotide, antisense; SC; Mice (SCID); 14 days; Tissue perfusion (intratumoral); comparison of IP injections vs. sc mp; cancer (pancreatic ductal carcinoma); transplantation; 200 ul pump used.

P6148 Leaver,H.A., Wharton,S.B., Bell,H.S., Leaver-Yap,I.M.M., Whittle,I.R. Highly unsaturated fatty acid induced tumor regression in glioma pharm acodynamics and bioavailability of gamma linolenic acid in an implanta tion glioma model: effects on tumour biomass, apoptosis and neuronal t issue histology. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 2002; 67(-5-):283-292. >>> Linolenic acid, gamma; PBS; CSF/CNS (intratumoral); 2001; 3-7 days; Controls received mp w/ vehicle; tissue perfusion (tumor); cancer (glioma); ALZET brain infusion kit used.

P5991 Rubin,J.B., Kung,A.L., Klein,R.S., Chan,J.A., Sun,Y.P., Schmidt,K., Kieran,M.W., Luster,A.D., Segal,R.A. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003; 100(-23-):13513-13518. >>> AMD 3100; PBS; SC; Mice; 21 days; Controls received mp w/ vehicle; tissue perfusion (intratumoral); comparison of 2x daily injections vs. mp; cancer (glioblastoma); CXCR4 antagonist; 0.5 ul/hr pumps used; In vivo tumor imaging performed with IVIS imaging system (Xenogen); bioluminescence imaging (BLI).

P5835 Svechnikova,I., Gray,S.G., Kundrotiene,J., Ponthan,F., Kogner,P., Ekstrom,T.J. Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate. INTERNATIONAL JOURNAL OF ONCOLOGY 2003; 22(-3-):579-588. >>> Platelet factor-4; MMP-2 (hemopexin fragment); PBS; SC; CSF/CNS (intratumoral); Mice; 2004; 7 days; Controls received mp w/ PBS; tissue perfusion (tumor); dose-response (p.2502); comparison of IP injections SC systemic mp infusion vs. local intracranial mp infusion; long-term study; pumps replaced after 28 days in some groups; stability verified by in vitro assay; cancer (glioma); Angiogenesis inhibitors; COOH terminal fragment of PF-4 used; In vitro activity of agents confirmed for up to 16 days; "In conclusion, our data demonstrates that local intracerebral delivery of endogenous inhibitors by osmotic minipumps is a very effective modality for the treatment of aggressive tumors..." (p.2505); tissue perfusion (tumor);.

P5754 Galve-Roperh,I., Sanchez,C., Cortes,M.L., Gomez Del Pulgar,T., Izquierdo,M., Guzman,M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000; 6(-3-):313-319. >>> WIN-55,212-2; Cannabinol, delta-9-tetrahydro-; PBS; BSA; CSF/CNS (intratumoral); Rat; 2001; 7 days; Tissue perfusion (tumor); cancer; WIN-55,212-2 is a potent synthetic cannabinol agonist.

P5664 Hagedorn,M., Zilberberg,L., Wilting,J., Canron,X., Carrabba,G., Giussani,C., Pluderi,M., Bello,L., Bikfalvi,A. Domain swapping in a COOH-terminal fragment of platelet factor 4 generates potent angiogenesis inhibitors. Cancer Research 2002; 62(-23-):6884-6890. >>> Platelet factor 4 peptides; PBS; CSF/CNS (intratumoral); Mice (nude); 2004; 30 days; Controls received mp w/ vehicle; tissue perfusion (intratumoral); dose-response (p. 6888; fig 6); cancer; peptides; glioma; antiangiogenesis..

P5587 Lefranc,F., Camby,I., Belot,N., Bruyneel,E., Chaboteaux,C., Brotchi,J., Mareel,M., Salmon,I., Kiss,R. Gastrin significantly modifies the migratory abilities of experimental glioma cells. Lab.Invest. 2002; 82(-9-):1241-1252. >>> Gastrin; SC; rat; 1002; 14 days; controls received mp with saline; tissue perfusion (tumor resection cavity); cancer.

P5489 Cuevas,P., Carceller,F., Diaz-Gonzalez,D., Cuevas,B., Fernandez,A., Garcia-Gomez,I., Dujovny,M. Inhibition of rat glioma growth by neomycin. Preliminary report. NEUROLOGICAL RESEARCH 2002; 24(-6-):522-524. >>> TIMP-1; TIMP-2; PBS; CSF/CNS (intratumoral); Rat; 2002; 26 days; Controls received mp w/ vehicle; tissue perfusion (tumor); functionality of mp verified by immunohistochemistry of agents; cancer; enzyme inhibitor; ALZET brain infusion kit used; MMP inhibitors (tissue inhibitors of metalloprotease = TIMP); rat glioma model.

P5357 Walker,T.L., Dass,C.R., Burton,M.A. Enhanced In Vivo tumour response from combination of carboplatin and low-dose c-myc antisense oligonucleotides. Anticancer Research 2002; 22(-4-):2237-2245. >>> Fibroblast growth factor, basic; Saline; IV (jugular); Intratumoral; Rat; 2004; 86 hours; Controls received mp w/ vehicle; tissue perfusion (intratumoral); cancer; peptides; bFGF delivered either by systemic IV infusion or intratumorally.

P5059 Davies,M.M., Burke,D., Carnochan,P., Glover,C., Kaur,S., Allen-Mersh,T.G. Basic fibroblast growth factor infusion increases tumour vascularity, blood flow and chemotherapy uptake. Acta Oncologica 2002; 41(-1-):84-90. >>> Fibroblast Growth Factor, Basic; Saline; IV (jugular); Intratumoral;; rat; 10, 14, or 28 days; controls received mp w/ vehicle; tissue perfusion (tumor); cancer; one group received 10-day saline infusion by pump, followed by 14-day bFGF or saline infusion from a second pump.

P4478 Redgate,E.S., Grudziak,A.G., Deutsch,M., Boggs,S.S. Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.. Journal of Neuro-oncology 1999; 42(--):123-130. >>> Spermidine; Putrescine; Ornithine, difluoromethyl-;; Radio-isotopes; 3H tracer; CSF;; CSF/CNS;; rat;; 14 days;; Controls received mp w/vehicle; tissue perfusion (intratumoral); cancer; polyamines; delayed delivery for 3 days.

P4283 Pollina,J., Plunkett,R.J., Ciesielski,M.J., Lis,A., Barone,T.A., Greenberg,S.J., Fenstermaker,R.A. Intratumoral infusion of topotecan prolongs survival in the nude rat intracranial U87 human glioma model. Journal of Neuro-oncology 1998; 39(--):217-225. >>> Topotecan;; Saline;; CSF/CNS (glioma);; rat (nude);; 1003D;; 10 hours;; controls received mp w/ vehicle or no treatment; tissue perfusion (tumor); functionality of mp verified by examining pumps to see if they were empty; no stress (p. 220); cancer; peptides; topotecan is a DNA topoisomerase I inhibitor;.

P4112 Hautmann,S., Huland,E., Wulbrand,A., Friedrich,M., Huland,H. Treatment of metastatic hormone refractory adenocarcinoma of the prostate (mat ly ly) with micro-osmotic interleukin-2 pump in male copenhagen rats. Eur.Urol. 1998; 34(--):265-266. >>> Interleukin-2; Albumin; intratumoral; rat; no duration posted; controls received mp w/albumin; tissue perfusion (intratumoral); cancer (prostate); immunology; peptides.

P3860 Zhu,J., Zhang,L., Hanisch,U.K., Felgner,P.L., Reszka,R. A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy. Gene Therapy 1996; 3(--):472-476. >>> Liposomes; Gene, herpes simplex virus thymidine kinase; Gene, lacZ; CSF/CNS (caudate nucleus); Rat; 1003D; 3 days; controls received mp w/LacZ gene; tissue perfusion (tumor); functionality of mp verified by gene expression; comparison of intracerebral injections vs. mp; no stress (see pg.473); stability verified by gene expression; ALZET brain infusion kit used; cancer; gene therapy; "DNA-liposome complexes were stable within minipumps at body temperature (37C) for 1-3 days." (pg.474); "continuous administration of DNA-liposome complexes did not result in significant in vivo toxicity." (pg.474).

P3783 Tsuchida,E., Urano,M. The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma. Int.J.Radiat.Oncol.Biol.Phys. 1997; 39(-5-):1153-1161. >>> UCN-01; Citric acid; intratumoral; mice; 2001; 7 days; tissue perfusion (tumor); cancer; enzyme inhibitor.

P3780 Redgate,E.S., Grudziak,A.G., Deutsch,M., Boggs,S.S. Difluoromethylornithine enhanced uptake of tritiated putrescine in 9L rat brain tumors. Int.J.Radiat.Oncol.Biol.Phys. 1997; 38(-1-):169-174. >>> Ornithine, difluoromethyl-; Putrescine; CSF, artificial;; IP; CSF/CNS (corpus striatum); rat; 2001; 2002; no duration posted; tissue perfusion (tumor); functionality of mp verified by tumor radioactivity during infusion; stability verified (pg. 173); good methods (pp. 170-171); cancer; catheter used to delay drug infusion for 1 or 3 days after surgery.

P3523 Viola,J.J., Agbaria,R., Walbridge,S., Oshiro,E.M., Johns,D.G., Kelley,J.A., Oldfield,E.H., Ram,Z. In situ cyclopentenyl cytosine infusion for the treatment of experimental brain tumors. Cancer Res. 1995; 55(--):1306-1309. >>> Cyclopentenyl cytosine; Saline, normal; IP; intratumoral; rat; 2ML2; 2ML4; 6, 28 days; controls received mp w/ saline; tissue perfusion (tumor); cancer; ALZET brain infusion kit used; SC pump connected to IP catheter.

P2912 Okuda,T., Onda,M., Tokunaga,A., Sugisaki,Y. Stimulatory effect of EGF and inhibitory effect of sialoadenectomy on growth of an EGF receptor-hyperproducing human gastric cancer xenograft in nude mice. Jpn.J.Surg. 1994; 24(--):725-733. >>> Epidermal growth factor; PBS; SC; mice (nude); 2002; no duration posted; controls received mp with PBS; dose response; cancer; peptides; tissue perfusion (tumor); human EGF used.

P2525 Moses,B.L., Chan,D.W., Hruban,R.H., Forastiere,A., Richtsmeier,W.J. Comparison of intra-arterial and intravenous infusion of cisplatin for head and neck squamous cell carcinoma in a modified rat model. Arch Otolaryngol.Head Neck Surg. 1993; 119(--):612-617. >>> Cisplatin; IV (saphenous); IA (saphenous); rat (nude); 2ML1; 6 days; tissue perfusion (tumor xenograft); cancer.

P2481 Ikeda,Y., Carson,B.S., Lauer,J.A., Long,D.M. Therapeutic effects of local delivery of dexamethasone on experimental brain tumors and peritumoral brain edema. J.Neurosurg. 1993; 79(--):716-721. >>> Dexamethasone; intratumoral; rabbit; 6, 10 days; controls received no treatment; tissue perfusion (tumor); comparison of injections vs. mp; local vs. systemic treatment, graph pg. 719.

P2091 Riemenschneider,Th., Ruf,C., Kratzsch,H.C., Ziegler,M., Spath,G. Arterial, portal or combined arterio-portal regional chemotherapy in experimental liver tumours. J.Cancer Res.Clin.Oncol. 1992; 118(--):597-600. >>> Uridine, fluorodeoxy-; Heparin; Saline; IA (hepatic); IV (hepatic portal); rat; 2ML2; 7 days; tissue perfusion (tumor); cancer; hepatic artery accessed via gastroduodenal artery; portal vein via ileocolic vein; animal info (SD, F, 120-150 g).

P1707 Kimler,B.F., Martin,D.F., Evans,R.G., Morantz,R.A., Vats,T.S. Combination of radiation therapy and intercranial bleomycin in the 9L rat brain tumor model. Int.J.Radiat.Oncol.Biol.Phys. 1990; 18(--):1115-1121. >>> Bleomycin; CSF/CNS (intratumoral); cattle; rat; 2001; 2002; 7, 14 days; Antibiotic; controls received pumps with saline only; tissue perfusion (tumor); dose-response (graph, p. 1117); comparison of ip injections vs. mp.

P1470 Bouvier,G., Penn,R.D., Kroin,J.S., Beique,R.A., Guerard,M.-J., Lesage,J. Intratumoral chemotherapy with multiple sources. Ann.N.Y.Acad.Sci. 1989; 531(--):212-214. >>> Cisplatin; CSF/CNS (intratumoral); human; 2002; no duration posted; mp connected to multiple microcatheters and cannulae; tissue perfusion (tumor); cancer/immunology.

P0979 Bouvier,G., Penn,R.D., Kroin,J.S., Beique,R., Guerard,M.J. Direct delivery of medication into a brain tumor through multiple chronically implanted catheters. Neurosurgery 1987; 20(--):286-291. >>> Cisplatin; CSF/CNS (cranium); human; 2002; 10 days; mps connected to cath. bundle with a vinyl sheath; mps maint. in saline bath at 37C; 68 mps used in the subject; intratumoral chemo.; tissue perfusion (brain tumor); cancer.

P0406 Penn,R.D., Kroin,J.S., Harris,J.E., Chiu,K.M., Braun,D.P. Chronic intratumoral chemotherapy of a rat tumor with cisplatin and fluorouracil. Appl.Neurophysiol. 1983; 46(--):240-244. >>> Fluorouracil; Cisplatin; Saline; CSF/CNS (cerebellum); rat; 2001; 1 week; comparison of agents effects; tissue perfusion (intratumoral); cancer chemotherapy.