References on the Administration of Vasopressin
Using ALZET® Osmotic Pumps

16284 Zhou, L., Panasiuk, A., Downton, M., Zhao, D., Yang, B., Jia, Z., Yang, T. Systemic PPARgamma deletion causes severe disturbance in fluid homeostasis in mice. Physiol Genomics 2015; 47(-11-):541-7. >>> Vasopressin, 1-desamino-8-D-arginine; SC; mice; 1002; animal info (PPARy f/f mice and EsrCre/flox mice; 2-4 mo males); functionality of mp verified by urine osmolalities; Dose (0.25 ng/h);.

16189 Degerman, E., In't Zandt, R., Palbrink, A. K., Magnusson, M. Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI. Hear Res 2015; 330(-Pt A-):119-24. >>> Vasopressin; SC; mice; 2002; Controls received mp w/ vehicle; animal info:Five female C57BL6 mice and 4 and 6 female CBA/J mice of body weight 22 - 24 g (8 weeks of age); functionality of mp verified by MRI; dose-response (pg 3); MRI;“EH was induced, to our knowledge for the first time, by chronic administration of vasopressin via mini-osmotic pumps in two mouse strains using 9.4 T MRI in combination with Gd contrast agent intraperitoneally as read-out"(pg 5); Dose: 50 mg/100 g/day.

15219 Kittikulsuth, W., Stuart, D., Van Hoek, A.N., Stockand, J.D., Bugaj, V., Mironova, E., Blount, M.A., Kohan, D.E. Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na(+) and water excretion or arterial pressure. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2014; 306(-6-):F597-F607. >>> Vasopressin, 1-desamino-8-D-arginine-; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (DC AC3 KO); cardiovascular; bp measured using radiotelemetry;.

15102 Taveau, C., Chollet, C., Waeckel, L., Desposito, D., Bichet, D.G., Arthus, M.F., Magnan, C., Philippe, E., Paradis, V., Foufelle, F., Hainault, I., Enhorning, S., Velho, G., Roussel, R., Bankir, L., Melander, O., Bouby, N., Bouby, N. Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats. DIABETOLOGIA 2015; 58(--):1081-1090. >>> Vasopressin; IP; Rat; Animal info (male, Fa/fa Zucker, 7 weeks old); no stress (see pg. 1083-1084); diabetes;.

15026 Luetken, S.C., Frokiaer, J., Nielsen, S., Luetken, S.C. AVP-Induced Increase in AQP2 and p-AQP2 Is Blunted in Heart Failure during Cardiac Remodeling and Is Associated with Decreased AT1R Abundance in Rat Kidney. PLoS One 2015; 10(--):U754-U786. >>> Vasopressin, 1-desamino-8-D-arginine; Saline; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Munich-Wistar rat, 250g); cardiovascular; 1-desamino-8-D-arginine vasopressin aka DDAVP;.

14967 Hopp, K., Wang, X.F., Ye, H., Irazabal, M.V., Harris, P.C., Torres, V.E., Torres, V.E. Effects of hydration in rats and mice with polycystic kidney disease. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F261-F266. >>> Vasopressin, 1-deamino-8-D arginine; Saline; SC; Rat; mice; 1004; 2004; 2ML4; Controls received mp w/ vehicle; animal info (rat PCK, 3 weeks old; mice Pkd1 RC/RC or Pkd2 WS25/- 4 weeks old); pumps replaced every 3 weeks; cardiovascular;.

14895 Cil, O., Esteva-Font, C., Tas, S.T., Su, T., Lee, S., Anderson, M.O., Ertunc, M., Verkman, A.S., Verkman, A.S. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. KIDNEY INTERNATIONAL 2015; 88(--):311-320. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (female, Wistar, 200-260g); cardiovascular;.

14552 Cudnoch-Jedrzejewska, A., Puchalska, L., Szczepanska-Sadowska, E., Wsol, A., Kowalewski, S., Czarzasta, K., Cudnoch-Jedrzejewska, A. The effect of blockade of the central V1 vasopressin receptors on anhedonia in chronically stressed infarcted and non-infarcted rats. PHYSIOLOGY&BEHAVIOR 2014; 135(--):208-214. >>> Vasopressin, deamino-Pen1,O-Me-Tyr2,Arg8; CSF/CNS; Rat; 2ML4; Controls received mp w/ saline; animal info (male, Sprague Dawley, 8-10 weeks old); ALZET brain infusion kit used; no stress (see pg. 211); post op. care (buprenorphine 3ug/100g IP BID 2-3 days, Penicillin 10000IU/100g IM); behavioral testing (chronic mild stress); cardiovascular; Cannula placement verified via Evans blue dye postmortem; Vasopressin, deamino-Pen1,O-Me-Tyr2,Arg8 aka V1RANT is a V1 receptor antagonist; myocardial infarction;.

14383 Santillan, M.K., Santillan, D.A., Scroggins, S.M., Min, J.Y., Sandgren, J.A., Pearson, N.A., Leslie, K.K., Hunter, S.K., Zamba, G.K.D., Gibson-Corley, K.N., Grobe, J.L., Santillan, M.K. Vasopressin in Preeclampsia A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model. Hypertension 2014; 64(--):852-+. >>> Vasopressin, arginine; Saline; SC; Mice (pregnant); 1004; Controls received mp w/ vehicle; animal info (C57BL6J); bp measured using tail cuff; preeclampsia model.

13965 Talbot, J.J., Song, X.W., Wang, X.F., Rinschen, M.M., Doerr, N., LaRiviere, W.B., Schermer, B., Pei, Y.P., Torres, V.E., Weimbs, T., Weimbs, T. The Cleaved Cytoplasmic Tail of Polycystin-1 Regulates Src-Dependent STAT3 Activation. Journal of the American Society of Nephrology 2014; 25(--):1737-1748. >>> Vasopressin, 1-deamino-8-D-arginine; Rat; Animal info (PCK/Brattleboro, 3-10 weeks old); long-term study; cardiovascular;.

13506 Miranda, C.A., Lee, J.W., Chou, C.L., Knepper, M.A. Tolvaptan as a tool in renal physiology. American Journal of Physiology-Renal Physiology 2014; 306(-3-):F359-F366. >>> Tolvaptan; vasopressin, arginine; DMSO; glycerol; SC; Rat; 2ML1; 2001; Control animals received mp w/ vehicle; animal info (pathogen-free, Sprague Dawley, Brattleboro, 190-215 g, male); 50% DMSO used; 50% glycerol used;"The third alternative, osmotic minipumps, proved the most practical approach (versus food or water for tolvaptan infusion) pg F360; dose response (Fig 1); good methods (appendix 1);"alternative to dDAVP infusion in Brattleboro rats"pg F363.

13501 Kortenoeven, M.L.A., Sinke, A.P., Hadrup, N., Trimpert, C., Wetzels, J.F.M., Fenton, R.A., Deen, P.M.T. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. American Journal of Physiology-Renal Physiology 2013; 305(-12-):F1705-F1718. >>> Vasopressin, 1-deamino-8-D arginine; Saline, isotonic; SC; Rat; 1002; animal info (male, Wistar, 150-200 g).

13500 Paunescu, T.G., Lu, H.A.J., Russo, L.M., Pastor-Soler, N.M., Mckee, M., McLaughlin, M.M., Bartlett, B.E., Breton, S., Brown, D. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. American Journal of Physiology-Renal Physiology 2013; 305(-12-):F1783-F1795. >>> Vasopressin, 1-deamino-8-D arginine; SC; Rat; 2002; 2ML4; Animal info (Sprague Dawley, Lewis Evans, adult, male); pump functionality verified by pump removal/inspection and urine osmolality levels (Fig 2).

13418 Marir, R., Virsolvy, A., Wisniewski, K., Mion, J., Haddou, D., Galibert, E., Meraihi, Z., Desarmenien, M.G., Guillon, G. Pharmacological characterization of FE 201874, the first selective high affinity rat V(1A) vasopressin receptor agonist. British Journal of Pharmacology 2013; 170(-2-):278-292. >>> FE201874; arginine vasopressin; desmopressin; d[Leu4,Lys8]VP; [Thr4,Gly7]OT; Saline; DMSO; Cremophore; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 200-250g); 5% DMSO, 7.5% Cremophore used; dose-response (288); cardiovascular; Desmopressin aka dDAVP; FE 201874 is a selective agonist of the rat V1A receptor.

13187 Cabral, P.D., Herrera, M. Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb. American Journal of Physiology-Renal Physiology 2012; 303(-5-):F621-F629. >>> Vasopressin, 1-deamino-8-D arginine;; Rat; mice; Peptides; animal info (230-260g, C57Bl/6J).

12804 Ilori, T.O., Blount, M.A., Martin, C.F., Sands, J.M., Klein, J.D. Urine concentration in the diabetic mouse requires both urea and water transporters. American Journal of Physiology-Renal Physiology 2013; 304(-1-):F103-F111. >>> Vasopressin, 1-deamino-8-D arginine; SC; Mice; 2002; Animal info (wt, UT-A1/A3 KO).

12796 Park, E.J., Lim, J.S., Jung, H.J., Kim, E., Han, K.H., Kwon, T.H. The role of 70-kDa heat shock protein in dDAVP-induced AQP2 trafficking in kidney collecting duct cells. American Journal of Physiology-Renal Physiology 2013; 304(-7-):F958-F971. >>> Vasopressin, 1-deamino-8-D arginine; SC; Rat; Control animals received mp w/ saline; animal info (Sprague Dawley, 200-250 g).

12795 Wang, Y., Klein, J.D., Froehlich, O., Sands, J.M. Role of protein kinase C-alpha in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts. American Journal of Physiology-Renal Physiology 2013; 304(-2-):F233-F238. >>> Vasopressin, 1-deamino-8-D arginine; Mice; Animal info (PKC alpha -/-, wt).

12784 Barsony, J., Manigrasso, M.B., Xu, Q., Tam, H., Verbalis, J.G. Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats. AGE 2013; 35(-2-):271-288. >>> Vasopressin, 1-deamino-8-D arginine; SC; Rat; 2004; Animal info (Fisher Brown, Norway, F1 hybrid, young adult); pumps replaced monthly.

12572 Wang, X.F., Ye, H., Ward, C.J., Chu, J.Y.S., Masyuk, T.V., LaRusso, N.F., Harris, P.C., Chow, B.K.C., Torres, V.E. Insignificant effect of secretin in rodent models of polycystic kidney and liver disease. American Journal of Physiology-Renal Physiology 2012; 303(-7-):F1089-F1098. >>> Vasopressin, 1-deamino-8-D arginine; secretin; SC; Rat; mice; 1004; 2002; 2ML4; Controls received mp w/ vehicle; animal info (3 wks old, PKD2 -/WS25); pumps replaced every 2 weeks, every 4 weeks, or after 2 and 5 weeks; functionality of mp verified via plasma secretin levels; long-term study.

12483 Lee, Y.J., Lee, J.E., Choi, H.J., Lim, J.S., Jung, H.J., Baek, M.C., Frokiaer, J., Nielsen, S., Kwon, T.H. E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal. American Journal of Physiology-Renal Physiology 2011; 301(-4-):F883-F896. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 200-250 g).

11767 Gankam-Kengne, F., Soupart, A., Pochet, R., Brion, J.P., Decaux, G. Minocycline Protects against Neurologic Complications of Rapid Correction of Hyponatremia. Journal of the American Society of Nephrology 2010; 21(-12-):2099-2108. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2001; Animal info (male, Wistar, 250-300 g).

11714 Suzuki, H., Sugimura, Y., Iwama, S., Suzuki, H., Nobuaki, O., Nagasaki, H., Arima, H., Sawada, M., Oiso, Y. Minocycline Prevents Osmotic Demyelination Syndrome by Inhibiting the Activation of Microglia. Journal of the American Society of Nephrology 2010; 21(-12-):2090-2098. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; Animal info (Sprague-Dawley, 250-300 g).

11529 Pedersen, N.B., Hofmeister, M.V., Rosenbaek, L.L., Nielsen, J., Fenton, R.A. Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney International 2010; 78(-2-):160-169. >>> Candesartan; vasopressin, 1-deamino-8-D arginine; Saline, physiological; SC; Rat; 2001; Animal info (Munich Wistar, male).

11435 Kim, J.S., Kim, W.B., Kim, Y.B., Lee, Y., Kim, Y.S., Shen, F.Y., Lee, S.W., Park, D., Choi, H.J., Hur, J., Park, J.J., Han, H.C., Colwell, C.S., Cho, Y.W., Kim, Y.I. Chronic Hyperosmotic Stress Converts GABAergic Inhibition into Excitation in Vasopressin and Oxytocin Neurons in the Rat. Journal of Neuroscience 2011; 31(-37-):13312-13322. >>> Vasopressin, arginine; oxytocin receptor antagonist; AVP receptor antagonist; CSF, artificial; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 6-20 wks old); peptides; ALZET brain infusion kit 2 used.

11392 Hiroi, M., Morishita, Y., Hayashi, M., Ozaki, N., Sugimura, Y., Nagasaki, H., Shiota, A., Oiso, Y., Arima, H. Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 298(-2-):R486-R493. >>> Desmopressin arginine vasopressin; Acetic acid; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (female, FNDI, 1 mo old); pumps replaced on day 10 and 20.

11290 Cudnoch-Jedrzejewska, A., Szczepanska-Sadowska, E., Dobruch, J., Gomolka, R., Puchalska, L. Brain vasopressin V(1) receptors contribute to enhanced cardiovascular responses to acute stress in chronically stressed rats and rats with myocardial infarcton. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 298(-3-):R672-R680. >>> Arginine vasopressin; NaCl; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8-10 wks old); ALZET brain infusion kit used; cannula placement verified by injecting Evan's blue dye into the cannula and inspecting sagittal sections of the brain; 2ML sized pump used.

11125 Barsony, J., Sugimura, Y., Verbalis, J.G. Osteoclast Response to Low Extracellular Sodium and the Mechanism of Hyponatremia-induced Bone Loss. Journal of Biological Chemistry 2011; 286(-12-):10864-10875. >>> Vasopressin, 1-deamino-8-D arginine; SC; Rat; 2004; Animal info (22 mo old, F344 Brown Norway hybrid, 200 g); long-term study; pumps replaced monthly.

10886 Zelena, D., Domokos, A., Jain, S.K., Jankord, R., Filaretova, L. The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. Journal of Endocrinology 2009; 202(-2-):263-278. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; Animal info (adult, male, Brattleboro, di/di, 330 g, 10-12 wks old); compound also known as desmopressine; incorrectly listed rate of infusion as 1 ml/hr.

10867 Ivanova, L.N., Lavrinenko, V.A., Babina, A.V., Khegay, I.I. Structure and Concentration Capacity of the Kidneys in Brattleboro Rats under Conditions of Long-Term Vasopressin Treatment. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 2008; 146(-5-):642-646. >>> Vasopressin, arginine; SC; Rat; 2ML4; Controls received empty plastic capsules; animal info (2 months old, male, VP -/-); functionality of mp verified by osmolarity of excreted urine.

10635 Indrambarya, T., Boyd, J.H., Wang, Y.J., McConechy, M., Walley, K.R. Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. CRITICAL CARE 2009; 13(-3-):U361-U368. >>> Vasopressin, arginine; dobutamine; IP; Mice; 1003D; Controls received mp w/normal saline; animal info (10-14 wks old, male, C57B6); post op. care (buprenorphrine).

10574 Cai, Q., Nelson, S.K., McReynolds, M.R., amond-Stanic, M.K., Elliott, D., Brooks, H.L. Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect. American Journal of Physiology-Renal Physiology 2010; 299(-4-):F712-F719. >>> Vasopressin, 1-desamino-8-D arginine; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (AQP1KO, 8 wks old).

10558 Wang, W.D., Li, C.L., Summer, S., Falk, S., Schrier, R.W. Interaction between vasopressin and angiotensin II in vivo and in vitro: effect on aquaporins and urine concentration. American Journal of Physiology-Renal Physiology 2010; 299(-3-):F577-F584. >>> Vasopressin, 1-desamino-8-D arginine; losartan; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Wistar, 180-220 g).

10424 Miyazaki, T., Ohmoto, K., Hirose, T., Fujiki, H. Chronic hyponatremia impairs memory in rats: effects of vasopressin antagonist tolvaptan. Journal of Endocrinology 2010; 206(-1-):105-111. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; Controls received mp w/ saline; no stress (pg. 108); animal info (male, Spague-Dawley, 8 weeks old); dose-response (Fig. 1); endocrinology; behavioral testing (Irwin's test, rotarod treadmill test, passive avoidance test).

10393 Marshall, A.F., Jeweils, V.L., Kranz, P., Lee, Y.Z., Lin, W.L., Zdanski, C.J. Magnetic resonance imaging of guinea pig cochlea after vasopressin-induced or surgically induced endolymphatic hydrops. OTOLARYNGOLOGY-HEAD AND NECK SURGERY 2010; 142(-2-):260-265. >>> Vasopressin; SC; Guinea-pig; 2002; Animal info (male, albino, Hartley, 300-500 g).

10157 Kim, Y.H., Pham, T.D., Zheng, W., Hong, S., Baylis, C., Pech, V., Beierwaltes, W.H., Farley, D.B., Braverman, L.E., Verlander, J.W., Wall, S.M. Role of pendrin in iodide balance: going with the flow. American Journal of Physiology-Renal Physiology 2009; 297(-4-):F1069-F1079. >>> Vasopressin, 1-desamino-8-D arginine; Mice; 1002; Controls received mp w/ vehicle; animal Info (S/C26a4 -/-).

10089 LI, X.C., SHAO, Y., Zhuo, J.L. AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney International 2009; 76(-2-):169-177. >>> Vasopressin, 1-desamino-8-D-arginine; Insulin, FITC; IP; Mice; 2002; Controls were not treated; animal info (AT1A-KO, wt).

9794 Kim, C., Jeon, D., Kim, Y.H., Lee, C.J., Kim, H., Shin, H.S. Deletion of N-type Ca2+ Channel Cav2.2 Results in Hyperaggressive Behaviors in Mice. Journal of Biological Chemistry 2009; 284(-5-):2738-2745. >>> Vasopressin, 1-desamino-8-D arginine; PBS; CSF/CNS; Mice; Controls received mp w/vehicle; animal info (Cav 2.2 -/-, male, 10-15 wks old); behavoral testing (resident intruder testing).

9866 Moeller, H.B., Knepper, M.A., Fenton, R.A. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney International 2009; 75(-3-):295-303. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; SC; Rat; Controls received mp w/vehicle; animal info (Brattleboro).

9821 Kabilova, N.O., Bondar, A.A., Ivanova, L.N. Expression of type II hyaluronan-synthase gene in kidneys Wistar and Brattleboro rats with diabetes Insipidus: Effect of vasopressin and its analogues. Doklady Biochemistry and Biophysics 2009; 425(-1-):61-64. >>> Vasopressin; SC; Rat; Animal info (60 days old, Brattleboro, 200-250g).

9675 Nephew, B.C., Bridges, R.S. Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats. PHYSIOLOGY&BEHAVIOR 2008; 95(-1-2-):182-186. >>> Vasopressin, d(CH2)5Tyr(Me) Arginine; Saline; CSF/CNS; CSF/CNS (medial amygdala); Rat (pregnant); 2002; Controls received mp w/ vehicle; dose-response (fig 3); animal info (female, Sprague Dawley, GD18); V1a receptor antagonist; behavioral testing (maternal behavior, social recognition test, maternal memory test); cannula placement confirmed.

9633 Bosch, O.J., Neumann, I.D. Brain vasopressin is an important regulator of maternal behavior independent of dams'trait anxiety. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-44-):17139-17144. >>> Vasopressin, arginine; oxytocin; oligonucleotide, antisense; oligonucleotide, missense; Ringer's solution; CSF/CNS; CSF/CNS (medial preoptic area); Rat (pregnant); 1007D; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; antisense (AVP-R); peptides; multiple pumps per animal (2); post op. care (Enrofloxacin, Baytril); animal info (female, Wistar, HAB, LAB, 14 wks old); behavioral testing (maternal care, pup retrieval test, elevated plus maze); cannula placement and infusion sites verified with blue ink.

9606 Wakamatsu, S., Nonoguchi, H., Ikebe, M., Machida, K., Izumi, Y., Memetimin, H., Nakayama, Y., Nakanishi, T., Kohda, Y., Tomita, K. Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD. HYPERTENSION RESEARCH 2009; 32(-6-):481-487. >>> Vasopressin, 1-desamino-8-D-arginine; oxytocin; SC; Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague Dawley, 80-100 g.).

9573 Alonso, G., Galibert, E., Boulay, V., Guillou, A., Jean, A., Compan, V., Guillon, G. Sustained Elevated Levels of Circulating Vasopressin Selectively Stimulate the Proliferation of Kidney Tubular Cells via the Activation of V2 Receptors. Endocrinology 2009; 150(-1-):239-250. >>> Vasopressin; desmopressin; SC; Rat; 1007D; Controls received mp w/ vehicle; comparison of 2x daily IP injections vs. mp; animal info (male, Sprague Dawley, 2 months old).

9569 Boyd, J.H., Holmes, C.L., Wang, Y.J., Roberts, H., Walley, K.R. Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R. RESUSCITATION 2008; 79(-2-):325-331. >>> Vasopressin; IP; Mice; Controls received mp w/ saline; animal info (5-6 wks old, CD-1 female).

9417 Alonso, G., Gallibert, E., Lafont, C., Guillon, G. Intrahypothalamic angiogenesis induced by osmotic stimuli correlates with local hypoxia: A potential role of confined vasoconstriction induced by dendritic secretion of vasopressin. Endocrinology 2008; 149(-9-):4279-4288. >>> Vasopressin, 1-deamino-8-D-arginine; CSF/CNS; Rat; 1007D; Controls received mp w/ PBS; animal info (male, Wistar, Long Evans); dAVP; 26 gauge 10 mm cannula used.

9287 Zhang, Y., Sands, J.M., Kohan, D.E., Nelson, R.D., Martin, C.F., Carlson, N.G., Kamerath, C.D., Ge, Y.Q., Klein, J.D., Kishore, B.K. Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. American Journal of Physiology-Renal Physiology 2008; 295(-6-):F1715-F1724. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile; SC; Mice (knockout); 1007D; Animal info (P2Y2-R KO, wt, 2 and 5 months old); post op. care (ketorolac); nephrology.

9127 Li, Y.D., Shaw, S., Kamsteeg, E.J., Vandewalle, A., Deen, P.M.T. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. Journal of the American Society of Nephrology 2006; 17(-4-):1063-1072. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile, physiological; SC; Rat; 2001; Functionality of mp verified by reduction of urine output; pumps replaced after 7 days; peptides; animal info (male, Wistar, Brattleboro, 250-350 g.); nephrology.

9126 Lim, S.W., Ahn, K.O., Sheen, M.R., Jeon, U.S., Kim, J., Yang, C.W., Kwon, H.M. Downregulation of renal sodium transporters and tonicity-responsive enhancer binding protein by long-term treatment with cyclosporin A. Journal of the American Society of Nephrology 2007; 18(-2-):421-429. >>> Vasopressin, 1-deamino-8-D-arginine; PBS; Rat; Peptides; animal info (male, Sprague Dawley, 220-240 g.); nephrology.

9071 Callewaere, C., Fernette, B., Raison, D., Mechighel, P., Burlet, A., Calas, A., Kitabgi, P., Parsadaniantz, S.M., Rostene, W. Cellular and subcellular evidence for neuronal interaction between the chemokine stromal cell-derived factor-1/CXCL 12 and vasopressin: Regulation in the hypothalamo-neurohypophysial system of the Brattleboro rats. Endocrinology 2008; 149(-1-):310-319. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, isotonic; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (male, Brattleboro, DI); endocrinology.

8963 Lu, H.A.J., Sun, T.X., Matsuzaki, T., Yi, X.H., Eswara, J., Bouley, R., Mckee, M., Brown, D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. Journal of Biological Chemistry 2007; 282(-39-):28721-28732. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; Animal info (Sprague-Dawley); nephrology.

8829 de Seigneux, S., Nielsen, J., Olesen, E.T.B., Dimke, H., Kwon, T.H., Frokiaer, J., Nielsen, S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

8665 Yue, C.M., Mutsuga, N., Verbalis, J., Gainer, H. Microarray analysis of gene expression in the supraoptic nucleus of normoosmotic and hypoosmotic rats. Cellular and Molecular Neurobiology 2006; 26(-4-6-):959-978. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Animal info (male, Sprague-Dawley, 260-320 g).

8643 Kazama, I., Arata, T., Michimata, M., Hatano, R., Suzuki, M., Miyama, N., Sanada, S., Sato, A., Satomi, S., Ejima, Y., Sasaki, S., Matsubara, M. Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2007; 22(-1-):68-76. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; No Stress (see pg. 71); animal info (male, Sprague-Dawley, 200g.); Nephrology.

8601 Takefuji, S., Murase, T., Sugimura, Y., Takagishi, Y., Hayasaka, S., Oiso, Y., Murata, Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Experimental Neurology 2007; 204(-1-):88-94. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Animal Info (male, Sprague-Dawley, 7-8 wks old, 250-300g.); hyponatremia model.

8534 Cristia, E., Amat, C., Naftalin, R.J., Moreto, M. Role of vasopressin in rat distal colon function. JOURNAL OF PHYSIOLOGY-LONDON 2007; 578(-2-):413-424. >>> Vasopressin; Saline; SC; Rat; 2002; Animal info (male, Sprague-Dawley, 200-250 grams).

8460 Hoorn, E.J., Hoffert, J.D., Knepper, M.A. Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape. Journal of the American Society of Nephrology 2005; 16(-10-):2852-2863. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; Animal info (male, Sprague-Dawley); bioinformatics.

8217 Mutsuga, N., Gainer, H. Molecular analysis of the magnocellular neuroendocrine phenotype: From the micropunch to laser microdissection. Neurochemical Research 2006; 31(-2-):189-199. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2002; Animal info (male, Sprague-Dawley, 260-320g.); bioinformatics.

8254 Wada, K., Matsuyawa, U., Fujimori, A., Arai, Y., Sudoh, K., Sasamata, M., Miyata, K. A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). BIOLOGICAL&PHARMACEUTICAL BULLETIN 2007; 30(-1-):91-95. >>> Vasopressin, arginine; Water, distilled; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 244-313 grams).

8145 Tiwari, S., Packer, R.K., Hu, X.Q., Sugimura, Y., Verbalis, J.G., Ecelbarger, C.A. Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F49-F57. >>> Vasopressin, 1-desamino-8-D-arginine; aldosterone; SC; Rat; 2002; Blood pressure taken; replacement therapy (adrenalectomy); multiple pumps per animal (2); animal info (male, Sprague-Dawley, 275 grams, ADX); dDAVP; one pump for each drug.

8137 Sauter, D., Fernandes, S., Goncalves-Mendes, N., Boulkroun, S., Bankir, L., Loffing, J., Bouby, N. Long-term effects of vasopressin on the subcellular localization of ENaC in the renal collecting system. Kidney International 2006; 69(-6-):1024-1032. >>> Vasopressin, 1-desamino-8-D-arginine; Rat; 2002; Animal info (Sprague-Dawley, male, 200 grams); dDAVP.

8128 Pisitkun, T., Bieniek, J., Tchapyjnikov, D., Wang, G.H., Wu, W.W., Shen, R.F., Knepper, M.A. High-throughput identification of IMCD proteins using LC-MS/MS. PHYSIOLOGICAL GENOMICS 2006; 25(-2-):263-276. >>> Vasopressin, 1-desamino-8-D-arginine; Saline, isotonic; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Brattleboro, 360-430 g.).

7936 Zelena, D., Mergl, Z., Makara, G.B. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: Studies in Brattleboro rats. Brain Research Bulletin 2006; 69(-1-):48-56. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; Controls received sham surgery; pumps replaced after 10 days; animal info (male, brattleboro, di/di, di/+); v2 agonist; diabetes; A.K.A dDavp or Desmopressin or desmopresinum.

7854 Silver, S.M., Schroeder, B.M., Sterns, R.H., Rojiani, A.M. Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. Journal of Neuropathology and Experimental Neurology 2006; 65(-1-):37-44. >>> Vasopressin, arginine; SC; Rat; 2001; Controls received mp w/ agent and varied secondary treatment; animal info (male, Sprague-Dawley 275-350 g, hyponatremia).

7786 Sun, R.J., Miller, R.L., Hemmert, A.C., Zhang, P., Shi, H.H., Nelson, R.D., Kishore, B.K. Chronic dDAVP infusion in rats decreases the expression of P2Y2 receptor in inner medulla and P2Y2 receptor-mediated PGE2 release by IMCD. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F768-F776. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile; SC; Rat; 2002; Controls received mp w/ vehicle; dose-response (figs. 8, 9); animal info (male, Sprague-Dawley 309 g); agent also known as dDAVP or desmopressin.

7674 Ge, Y.Q., Stricklett, P.K., Hughes, A.K., Yanagisawa, M., Kohan, D.E. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F692-F698. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice (transgenic); 1002; .

7574 Hassan, A., Tian, Y., Zheng, W., Ji, H., Sandberg, K., Verbalis, J.G. Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. PHYSIOLOGICAL GENOMICS 2005; 21(-3-):382-388. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice; 1002; .

7561 Sugimura, Y., Murase, T., Takefuji, S., Hayasaka, S., Takagishi, Y., Oiso, Y., Murata, Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Experimental Neurology 2005; 192(-1-):178-183. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Peptides.

7453 Miyazaki, T., Yamamura, Y., Onogawa, T., Nakamura, S., Kinoshita, S., Nakayama, S., Fujiki, H., Mori, T. Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia. Endocrinology 2005; 146(-7-):3037-3043. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Controls received mp w/ saline; peptides.

7441 Hoffert, J.D., Chou, C.L., Fenton, R.A., Knepper, M.A. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. Journal of Biological Chemistry 2005; 280(-14-):13624-13630. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; Controls received mp w/ vehicle.

7397 Mutsuga, N., Shahar, T., Verbalis, J.G., Xiang, C.C., Brownstein, M.J., Gainer, H. Regulation of gene expression in magnocellular neurons in rat supraoptic nucleus during sustained hypoosmolality. Endocrinology 2005; 146(-3-):1254-1267. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Controls received mp w/ agent w/out water-loading diet; no stress (see pg. 1258); endocrinology.

7363 Vagnes, O.B., Hansen, F.H., Feng, J.J., Iversen, B.M., Arendshorst, W.J. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. American Journal of Physiology-Renal Physiology 2005; 288(-6-):F1249-F1256. >>> Vasopressin, arginine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; cardiovascular; AVP.

7354 Ge, Y.Q., Ahn, D., Stricklett, P.K., Hughes, A.K., Yanagisawa, M., Verbalis, J.G., Kohan, D.E. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F912-F920. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice (transgenic); 1002; .

7355 Kwon, T.H., Nielsen, J., Knepper, M.A., Frokiaer, J., Nielsen, S. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. American Journal of Physiology-Renal Physiology 2005; 288(-4-):F673-F684. >>> Vasopressin, 1-deamino-8-D-arginine; candesartan; Saline, physiological; Na2CO3; SC; Rat; 2001; Controls received mp w/ vehicle; multiple pumps per animal (2); mp primed 4 hours in 37 degrees celsius saline.

7179 Kotnik, P., Nielsen, J., Kwon, T.H., Krzisnik, C., Frokiaer, J., Nielsen, S. Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F1053-F1068. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; Controls received mp w/ vehicle.

6883 Brooks, H.L., Ageloff, S., Kwon, T.H., Brandt, W., Terris, J.M., Seth, A., Michea, L., Nielsen, S., Fenton, R., Knepper, M.A. cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F218-F228. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; SC; Rat; 2001; Controls received mp w/ vehicle.

6907 van Balkom, B.W.M., Hoffert, J.D., Chou, C.L., Knepper, M.A. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. American Journal of Physiology-Renal Physiology 2004; 286(-2-):F216-F224. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle.

6808 Lim, S.W., Li, C., Sun, B.K., Han, K.H., Kim, W.Y., Oh, Y.W., Lee, J.U., Kador, P.F., Knepper, M.A., Sands, J.M., Kim, J., Yang, C.W. Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney. American Journal of Physiology-Renal Physiology 2004; 287(-1-):F139-F151. >>> Vasopressin, 1-desamino-8-D arginine; Sodium Chloride; SC; Rat; 2ML1; .

6848 Combet, S., Geffroy, N., Berthonaud, V., Dick, B., Teillet, L., Verbavatz, J.M., Corman, B., Trinh-Trang-Tan, M.M. Correction of age-related polyuria by Vasopressin, 1-desamino-8-D arginine: molecular analysis of aqu aporins and urea transporters. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F199-F208. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; Controls received mp w/ saline; dose-response (p. F201); no stress (see pg.F201); peptides.

6773 Zhang, M.Z., Lopez, P.S., McKanna, J.A., Harris, R.C. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology 2004; 145(-3-):1402-1409. >>> Vasopressin, arginine-8-; Vasopressin, 1-desamino-8-D arginine; PV-OT; D3PVP; Water, distilled; SC; Rat; 2002; Controls received mp w/ vehicle; replacement therapy (hypophysectomy); dose-response (table 1); comparison of IM or IP injections vs. mp; PV-OT is a V1a receptor agonist, D3PVP is a Vlb receptor agonist; dDVAP is a V2 receptor agonist.

6657 Loyher, M.L., Mutin, M., Woo, S.K., Kwon, H.M., Tappaz, M.L. Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neuroscience 2004; 124(-1-):89-104. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2002; Controls received sham treatment.

6640 Massieu, L., Montiel, T., Robles, G., Quesada, O. Brain amino acids during hyponatremia in vivo: Clinical observations and experimental studies. Neurochemical Research 2004; 29(-1-):73-81. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2001; Vasopressin, 1-desamino-8-D arginine plasma levels taken.

6573 Kim, D.G., Sands, J.M., Klein, J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F760-F766. >>> Vasopressin; Saline; SC; Rat; 2002; Functionality of mp verified by urine osmolality; diabetes.

6550 Windle, R.J., Kershaw, Y.M., Shanks, N., Wood, S.A., Lightman, S.L., Ingram, C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. Journal of Neuroscience 2004; 24(-12-):2974-2982. >>> Oxytocin; vasopressin; Saline; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; ALZET brain infusion kit; peptides; dental cement used.

6165 Michimata, M., Mizukami, K., Suzuki, M., Kazama, I., Nakamura, Y., Suzuki, K., Yanagisawa, T., Imai, Y., Sasaki, S., Matsubara, M. Vasopressin-independent renal urinary concentration: Increased rBSC1 and enhanced countercurrent multiplication. Kidney International 2003; 64(-3-):933-938. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; Vasopressin, 1-desamino-8-D arginine is desmopressin acetate.

6154 Murase, T., Tian, Y., Fang, X.Y., Verbalis, J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

6095 Zhang, Z., Ferraris, J.D., Brooks, H.L., Brisc, I., Burg, M.B. Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. American Journal of Physiology-Renal Physiology 2003; 285(-4-):F688-F693. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; Vasopressin, 1-desamino-8-D arginine is a V2 selective vasopressin agonist.

5941 Bardoux, P., Bichet, D.G., Martin, H., Gallois, Y., Marre, M., Arthus, M.F., Lonergan, M., Ruel, N., Bouby, N., Bankir, L. Vasopressin increases urinary albumin excretion in rats and humans: involvement of V-2 receptors and the renin-angiotensin system. NEPHROLOGY DIALYSIS TRANSPLANTATION 2003; 18(-3-):497-506. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; 2001; Comparison of acute IP injections chronic vs. mp.

5900 Christensen, B.M., Wang, W.D., Frokiaer, J., Nielsen, S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. American Journal of Physiology-Renal Physiology 2003; 284(-4-):F701-F717. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; Controls received mp w/ vehicle; peptides; Vasopressin, 1-desamino-8-D arginine (1-deamino-(8-D-arginine)-vasopressin) is a V2 selective vasopressin agonist.

5787 Somponpun, S.J., Sladek, C.D. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Journal of Neuroscience 2003; 23(-10-):4261-4269. >>> Vasopressin, 1-desamino-8-D arginine; Acetic Acid; SC; Rat; 2002; Controls received mp w/ vehicle; vasopressin plasma levels checked; peptides; vp analog (Vasopressin, 1-desamino-8-D arginine)..

5547 Trinh-Trang-Tan, M.M., Lasbennes, F., Gane, P., Roudier, N., Ripoche, P., Cartron, J.P., Bailly, P. UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney. Am. J. Physiol Renal Physiol 2002; 283(-5-):F912-F922. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; IP; Rat; Controls received mp w/ vehicle; synthetic selective V2 Vasopressin Agonist.

5538 Martin, P.Y., Bianchi, M., Roger, F., Niksic, L., Feraille, E. Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla. American Journal of Physiology-Renal Physiology 2002; 283(-3-):F559-F568. >>> Vasopressin, arginine; Saline; IP; Rat; Controls received mp w/ vehicle.

5208 Soupart, A., Silver, S., Schroeder, B., Sterns, R., Decaux, G. Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. Journal of the American Society of Nephrology 2002; 13(--):1433-1441. >>> Vasopressin, arginine-8-; SC; rat; 2001; Vasopressin induced hyponatremia; serum sodium levels checked.

5205 Silver, S.M., Schroeder, B.M., Sterns, R.H. Brain uptake of myoinositol after exogenous administration. Journal of the American Society of Nephrology 2002; 13(--):1255-1260. >>> Vasopressin; SC; rat; controls received mp w/ vehicle; peptides; synthetic vasopressin; chronic vasopressin induced hyponatremia; plasma sodium levels checked..

5149 Leng, G., Brown, C.H., Bull, P.M., Brown, D., Scullion, S., Currie, J., Blackburn-Munro, R.E., Feng, J.F., Onaka, T., Verbalis, J.G., Russell, J.A., Ludwig, M. Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: An experimental and theoretical analysis. Journal of Neuroscience 2001; 21(-17-):6967-6977. >>> Vasopressin, 1-deamino-8-D-arginine; SC; rat; 2002; peptides; hyponatremia; dDAVP or desmopressin or desmopresinum.

5007 Ecelbarger, C.A., Knepper, M.A., Verbalis, J.G. Increased abundance of distal sodium transporters in rat kidney during vasopressin escape. Journal of the American Society of Nephrology 2001; 12(--):207-217. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 2002; peptides; Vasopressin, 1-desamino-8-D arginine is a V2 selective vasopressin agonist;.

4989 Baker, E.A., Tian, Y., Adler, S., Verbalis, J.G. Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia. Experimental Neurology 2000; 165(--):221-230. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; functionality of mp verified by plasma sodium levels; peptides; Vasopressin, 1-desamino-8-D arginine is an arginine vasopressin V2-receptor agonist that causes hyponatremia..

4970 Glasgow, E., Murase, T., Zhang, B.J., Verbalis, J.G., Gainer, H. Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2000; 279(--):R1239-R1250. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2002; functionality of mp verified by plasma sodium levels; dose response (table 1 p. R1240); peptides; Vasopressin, 1-desamino-8-D arginine induced hyponatremia.

4807 Ecelbarger, C.A, Kim, G.-H, Knepper, M.A, Liu, J, Tate, M, Welling, P.A, Wade, J.B  J. Am. Soc. Nephrol 2001; 12(--):10-18. >>> Vasopressin, 1-desamino-8-D arginine;; Saline;; rat;; 2001;; Controls received mp w/ vehicle; peptides; Barttner's Disease; d-DAVP is 1-deamino-(8-D-arginine)-vasopressin;.

4549 Wade, J.B, Lee, A.J, Liu, J, Ecelbarger, C.A, Mitchell, C, Bradford, A.D, Terris, J, Kim, G.-H, Knepper, M.A  Am. J. Physiological. Renal Physiol 2000; 278(--):F52-F62. >>> Vasopressin, 1-desamino-8-D arginine; Saline;; SC;; rat;; 2002;; controls received mp w/vehicle; peptides;.

 

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“Mini-pumps were used to eliminate stress associated with multiple daily injections.” Akhter et al., Journal of Orthopaedic Research 2002;21:14-19.