References on the Administration of Vasopressin
Using ALZET^® Osmotic Pumps

Q0874 Barsony,J., Sugimura,Y., Verbalis,J.G. Osteoclast Response to Low Extracellular Sodium and the Mechanism of Hyponatremia-induced Bone Loss. Journal of Biological Chemistry 2011; 286(-12-):10864-10875. >>> Vasopressin, 1-deamino-8-D arginine; SC; Rat; 2004; 3 months; Animal info (22 mo old, F344 Brown Norway hybrid, 200 g); long-term study; pumps replaced monthly.

Q0325 Cai,Q., Nelson,S.K., McReynolds,M.R., amond-Stanic,M.K., Elliott,D., Brooks,H.L. Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect. American Journal of Physiology-Renal Physiology 2010; 299(-4-):F712-F719. >>> Vasopressin, 1-desamino-8-D arginine; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (AQP1KO, 8 wks old).

Q0145 Marshall,A.F., Jeweils,V.L., Kranz,P., Lee,Y.Z., Lin,W.L., Zdanski,C.J. Magnetic resonance imaging of guinea pig cochlea after vasopressin-induced or surgically induced endolymphatic hydrops. OTOLARYNGOLOGY-HEAD AND NECK SURGERY 2010; 142(-2-):260-265. >>> Vasopressin; SC; Guinea-pig; 2002; 7, 14 days; Animal info (male, albino, Hartley, 300-500 g).

Q0176 Miyazaki,T., Ohmoto,K., Hirose,T., Fujiki,H. Chronic hyponatremia impairs memory in rats: effects of vasopressin antagonist tolvaptan. Journal of Endocrinology 2010; 206(-1-):105-111. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; 14 days; Controls received mp w/ saline; no stress (pg. 108); animal info (male, Spague-Dawley, 8 weeks old); dose-response (Fig. 1); endocrinology; behavioral testing (Irwin's test, rotarod treadmill test, passive avoidance test).

Q0309 Wang,W.D., Li,C.L., Summer,S., Falk,S., Schrier,R.W. Interaction between vasopressin and angiotensin II in vivo and in vitro: effect on aquaporins and urine concentration. American Journal of Physiology-Renal Physiology 2010; 299(-3-):F577-F584. >>> Vasopressin, 1-desamino-8-D arginine; losartan; SC; Rat; 1003D; 2 days; Controls received mp w/ vehicle; animal info (male, Wistar, 180-220 g).

P9332 Alonso,G., Galibert,E., Boulay,V., Guillou,A., Jean,A., Compan,V., Guillon,G. Sustained Elevated Levels of Circulating Vasopressin Selectively Stimulate the Proliferation of Kidney Tubular Cells via the Activation of V2 Receptors. Endocrinology 2009; 150(-1-):239-250. >>> Vasopressin; desmopressin; SC; Rat; 1007D; 3 or 6 days; Controls received mp w/ vehicle; comparison of 2x daily IP injections vs. mp; animal info (male, Sprague Dawley, 2 months old).

Q0386 Indrambarya,T., Boyd,J.H., Wang,Y.J., McConechy,M., Walley,K.R. Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. CRITICAL CARE 2009; 13(-3-):U361-U368. >>> Vasopressin, arginine; dobutamine; IP; Mice; 1003D; ; Controls received mp w/normal saline; animal info (10-14 wks old, male, C57B6); post op. care (buprenorphrine).

P9565 Kabilova,N.O., Bondar,A.A., Ivanova,L.N. Expression of type II hyaluronan-synthase gene in kidneys Wistar and Brattleboro rats with diabetes Insipidus: Effect of vasopressin and its analogues. Doklady Biochemistry and Biophysics 2009; 425(-1-):61-64. >>> Vasopressin; SC; Rat; 3 days; Animal info (60 days old, Brattleboro, 200-250g).

P9603 Kim,C., Jeon,D., Kim,Y.H., Lee,C.J., Kim,H., Shin,H.S. Deletion of N-type Ca2+ Channel Cav2.2 Results in Hyperaggressive Behaviors in Mice. Journal of Biological Chemistry 2009; 284(-5-):2738-2745. >>> Vasopressin, 1-desamino-8-D arginine; PBS; CSF/CNS; Mice; ; Controls received mp w/vehicle; animal info (Cav 2.2 -/-, male, 10-15 wks old); behavoral testing (resident intruder testing).

P9914 Kim,Y.H., Pham,T.D., Zheng,W., Hong,S., Baylis,C., Pech,V., Beierwaltes,W.H., Farley,D.B., Braverman,L.E., Verlander,J.W., Wall,S.M. Role of pendrin in iodide balance: going with the flow. American Journal of Physiology-Renal Physiology 2009; 297(-4-):F1069-F1079. >>> Vasopressin, 1-desamino-8-D arginine; Mice; 1002; 10 days; Controls received mp w/ vehicle; animal Info (S/C26a4 -/-).

P9672 LI,X.C., SHAO,Y., Zhuo,J.L. AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney International 2009; 76(-2-):169-177. >>> Vasopressin, 1-desamino-8-D-arginine; Insulin, FITC; IP; Mice; 2002; 2 weeks; Controls were not treated; animal info (AT1A-KO, wt).

P9590 Moeller,H.B., Knepper,M.A., Fenton,R.A. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney International 2009; 75(-3-):295-303. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; SC; Rat; 5 days; Controls received mp w/vehicle; animal info (Brattleboro).

P9365 Wakamatsu,S., Nonoguchi,H., Ikebe,M., Machida,K., Izumi,Y., Memetimin,H., Nakayama,Y., Nakanishi,T., Kohda,Y., Tomita,K. Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD. HYPERTENSION RESEARCH 2009; 32(-6-):481-487. >>> Vasopressin, 1-desamino-8-D-arginine; oxytocin; SC; Rat; 2002; 4 days; Controls received mp w/ saline; animal info (male, Sprague Dawley, 80-100 g.).

Q0637 Zelena,D., Domokos,A., Jain,S.K., Jankord,R., Filaretova,L. The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. Journal of Endocrinology 2009; 202(-2-):263-278. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; ; Animal info (adult, male, Brattleboro, di/di, 330 g, 10-12 wks old); compound also known as desmopressine; incorrectly listed rate of infusion as 1 ml/hr.

P9182 Alonso,G., Gallibert,E., Lafont,C., Guillon,G. Intrahypothalamic angiogenesis induced by osmotic stimuli correlates with local hypoxia: A potential role of confined vasoconstriction induced by dendritic secretion of vasopressin. Endocrinology 2008; 149(-9-):4279-4288. >>> Vasopressin, 1-deamino-8-D-arginine; CSF/CNS; Rat; 1007D; 3, 6 days; Controls received mp w/ PBS; animal info (male, Wistar, Long Evans); dAVP; 26 gauge 10 mm cannula used.

P9392 Bosch,O.J., Neumann,I.D. Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-44-):17139-17144. >>> Vasopressin, arginine; oxytocin; oligonucleotide, antisense; oligonucleotide, missense; Ringer's solution; CSF/CNS; CSF/CNS (medial preoptic area); Rat (pregnant); 1007D; 5-7 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; antisense (AVP-R); peptides; multiple pumps per animal (2); post op. care (Enrofloxacin, Baytril); animal info (female, Wistar, HAB, LAB, 14 wks old); behavioral testing (maternal care, pup retrieval test, elevated plus maze); cannula placement and infusion sites verified with blue ink.

P9328 Boyd,J.H., Holmes,C.L., Wang,Y.J., Roberts,H., Walley,K.R. Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R. RESUSCITATION 2008; 79(-2-):325-331. >>> Vasopressin; IP; Mice; ; Controls received mp w/ saline; animal info (5-6 wks old, CD-1 female).

P8840 Callewaere,C., Fernette,B., Raison,D., Mechighel,P., Burlet,A., Calas,A., Kitabgi,P., Parsadaniantz,S.M., Rostene,W. Cellular and subcellular evidence for neuronal interaction between the chemokine stromal cell-derived factor-1/CXCL 12 and vasopressin: Regulation in the hypothalamo-neurohypophysial system of the Brattleboro rats. Endocrinology 2008; 149(-1-):310-319. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, isotonic; SC; Rat; 1002; 10 days; Controls received mp w/ vehicle; animal info (male, Brattleboro, DI); endocrinology.

Q0618 Ivanova,L.N., Lavrinenko,V.A., Babina,A.V., Khegay,I.I. Structure and Concentration Capacity of the Kidneys in Brattleboro Rats under Conditions of Long-Term Vasopressin Treatment. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 2008; 146(-5-):642-646. >>> Vasopressin, arginine; SC; Rat; 2ML4; 28 days; Controls received empty plastic capsules; animal info (2 months old, male, VP -/-); functionality of mp verified by osmolarity of excreted urine.

P9433 Nephew,B.C., Bridges,R.S. Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats. PHYSIOLOGY&BEHAVIOR 2008; 95(-1-2-):182-186. >>> Vasopressin, d(CH2)5Tyr(Me) Arginine; Saline; CSF/CNS; CSF/CNS (medial amygdala); Rat (pregnant); 2002; 4-6 days; Controls received mp w/ vehicle; dose-response (fig 3); animal info (female, Sprague Dawley, GD18); V1a receptor antagonist; behavioral testing (maternal behavior, social recognition test, maternal memory test); cannula placement confirmed.

P9052 Zhang,Y., Sands,J.M., Kohan,D.E., Nelson,R.D., Martin,C.F., Carlson,N.G., Kamerath,C.D., Ge,Y.Q., Klein,J.D., Kishore,B.K. Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. American Journal of Physiology-Renal Physiology 2008; 295(-6-):F1715-F1724. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile; SC; Mice (knockout); 1007D; 5 days; Animal info (P2Y2-R KO, wt, 2 and 5 months old); post op. care (ketorolac); nephrology.

P8333 Cristia,E., Amat,C., Naftalin,R.J., Moreto,M. Role of vasopressin in rat distal colon function. JOURNAL OF PHYSIOLOGY-LONDON 2007; 578(-2-):413-424. >>> Vasopressin; Saline; SC; Rat; 2002; 3, 7 days; Animal info (male, Sprague-Dawley, 200-250 grams).

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8417 Kazama,I., Arata,T., Michimata,M., Hatano,R., Suzuki,M., Miyama,N., Sanada,S., Sato,A., Satomi,S., Ejima,Y., Sasaki,S., Matsubara,M. Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2007; 22(-1-):68-76. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; 14 days; No Stress (see pg. 71); animal info (male, Sprague-Dawley, 200g.); Nephrology.

P8895 Lim,S.W., Ahn,K.O., Sheen,M.R., Jeon,U.S., Kim,J., Yang,C.W., Kwon,H.M. Downregulation of renal sodium transporters and tonicity-responsive enhancer binding protein by long-term treatment with cyclosporin A. Journal of the American Society of Nephrology 2007; 18(-2-):421-429. >>> Vasopressin, 1-deamino-8-D-arginine; PBS; Rat; 7 days; Peptides; animal info (male, Sprague Dawley, 220-240 g.); nephrology.

P8733 Lu,H.A.J., Sun,T.X., Matsuzaki,T., Yi,X.H., Eswara,J., Bouley,R., Mckee,M., Brown,D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. Journal of Biological Chemistry 2007; 282(-39-):28721-28732. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 3 days; Animal info (Sprague-Dawley); nephrology.

P8375 Takefuji,S., Murase,T., Sugimura,Y., Takagishi,Y., Hayasaka,S., Oiso,Y., Murata,Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Experimental Neurology 2007; 204(-1-):88-94. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 14 days; Animal Info (male, Sprague-Dawley, 7-8 wks old, 250-300g.); hyponatremia model.

P7989 Wada,K., Matsuyawa,U., Fujimori,A., Arai,Y., Sudoh,K., Sasamata,M., Miyata,K. A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). BIOLOGICAL&PHARMACEUTICAL BULLETIN 2007; 30(-1-):91-95. >>> Vasopressin, arginine; Water, distilled; SC; Rat; 2001; ; Controls received mp w/ vehicle; animal info (male, Wistar, 244-313 grams).

P8896 Li,Y.D., Shaw,S., Kamsteeg,E.J., Vandewalle,A., Deen,P.M.T. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. Journal of the American Society of Nephrology 2006; 17(-4-):1063-1072. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile, physiological; SC; Rat; 2001; 10 days; Functionality of mp verified by reduction of urine output; pumps replaced after 7 days; peptides; animal info (male, Wistar, Brattleboro, 250-350 g.); nephrology.

P8072 Mutsuga,N., Gainer,H. Molecular analysis of the magnocellular neuroendocrine phenotype: From the micropunch to laser microdissection. Neurochemical Research 2006; 31(-2-):189-199. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2002; 7 days; Animal info (male, Sprague-Dawley, 260-320g.); bioinformatics.

P7911 Pisitkun,T., Bieniek,J., Tchapyjnikov,D., Wang,G.H., Wu,W.W., Shen,R.F., Knepper,M.A. High-throughput identification of IMCD proteins using LC-MS/MS. PHYSIOLOGICAL GENOMICS 2006; 25(-2-):263-276. >>> Vasopressin, 1-desamino-8-D-arginine; Saline, isotonic; SC; Rat; 2001; 3 days; Controls received mp w/ vehicle; animal info (male, Brattleboro, 360-430 g.).

P7919 Sauter,D., Fernandes,S., Goncalves-Mendes,N., Boulkroun,S., Bankir,L., Loffing,J., Bouby,N. Long-term effects of vasopressin on the subcellular localization of ENaC in the renal collecting system. Kidney International 2006; 69(-6-):1024-1032. >>> Vasopressin, 1-desamino-8-D-arginine; Rat; 2002; 5 days; Animal info (Sprague-Dawley, male, 200 grams); dDAVP.

P7641 Silver,S.M., Schroeder,B.M., Sterns,R.H., Rojiani,A.M. Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. Journal of Neuropathology and Experimental Neurology 2006; 65(-1-):37-44. >>> Vasopressin, arginine; SC; Rat; 2001; 4-7 days; Controls received mp w/ agent and varied secondary treatment; animal info (male, Sprague-Dawley 275-350 g, hyponatremia).

P7927 Tiwari,S., Packer,R.K., Hu,X.Q., Sugimura,Y., Verbalis,J.G., Ecelbarger,C.A. Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F49-F57. >>> Vasopressin, 1-desamino-8-D-arginine; aldosterone; SC; Rat; 2002; ; Blood pressure taken; replacement therapy (adrenalectomy); multiple pumps per animal (2); animal info (male, Sprague-Dawley, 275 grams, ADX); dDAVP; one pump for each drug.

P8439 Yue,C.M., Mutsuga,N., Verbalis,J., Gainer,H. Microarray analysis of gene expression in the supraoptic nucleus of normoosmotic and hypoosmotic rats. Cellular and Molecular Neurobiology 2006; 26(-4-6-):959-978. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Animal info (male, Sprague-Dawley, 260-320 g).

P7720 Zelena,D., Mergl,Z., Makara,G.B. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: Studies in Brattleboro rats. Brain Research Bulletin 2006; 69(-1-):48-56. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 18 days; Controls received sham surgery; pumps replaced after 10 days; animal info (male, brattleboro, di/di, di/+); v2 agonist; diabetes; A.K.A dDavp or Desmopressin or desmopresinum.

P7128 Ge,Y.Q., Ahn,D., Stricklett,P.K., Hughes,A.K., Yanagisawa,M., Verbalis,J.G., Kohan,D.E. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F912-F920. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice (transgenic); 1002; 6-7 days.

P7464 Ge,Y.Q., Stricklett,P.K., Hughes,A.K., Yanagisawa,M., Kohan,D.E. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F692-F698. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice (transgenic); 1002; 3-11 days.

P7364 Hassan,A., Tian,Y., Zheng,W., Ji,H., Sandberg,K., Verbalis,J.G. Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. PHYSIOLOGICAL GENOMICS 2005; 21(-3-):382-388. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice; 1002; 14 days.

P7231 Hoffert,J.D., Chou,C.L., Fenton,R.A., Knepper,M.A. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. Journal of Biological Chemistry 2005; 280(-14-):13624-13630. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle.

P8237 Hoorn,E.J., Hoffert,J.D., Knepper,M.A. Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape. Journal of the American Society of Nephrology 2005; 16(-10-):2852-2863. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 7 days; Animal info (male, Sprague-Dawley); bioinformatics.

P6971 Kotnik,P., Nielsen,J., Kwon,T.H., Krzisnik,C., Frokiaer,J., Nielsen,S. Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F1053-F1068. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 6 days; Controls received mp w/ vehicle.

P7127 Kwon,T.H., Nielsen,J., Knepper,M.A., Frokiaer,J., Nielsen,S. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. American Journal of Physiology-Renal Physiology 2005; 288(-4-):F673-F684. >>> Vasopressin, 1-deamino-8-D-arginine; candesartan; Saline, physiological; Na2CO3; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; multiple pumps per animal (2); mp primed 4 hours in 37 degrees celsius saline.

P7243 Miyazaki,T., Yamamura,Y., Onogawa,T., Nakamura,S., Kinoshita,S., Nakayama,S., Fujiki,H., Mori,T. Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia. Endocrinology 2005; 146(-7-):3037-3043. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 6, 14 days; Controls received mp w/ saline; peptides.

P7187 Mutsuga,N., Shahar,T., Verbalis,J.G., Xiang,C.C., Brownstein,M.J., Gainer,H. Regulation of gene expression in magnocellular neurons in rat supraoptic nucleus during sustained hypoosmolality. Endocrinology 2005; 146(-3-):1254-1267. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Controls received mp w/ agent w/out water-loading diet; no stress (see pg. 1258); endocrinology.

P7351 Sugimura,Y., Murase,T., Takefuji,S., Hayasaka,S., Takagishi,Y., Oiso,Y., Murata,Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Experimental Neurology 2005; 192(-1-):178-183. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Peptides.

P7578 Sun,R.J., Miller,R.L., Hemmert,A.C., Zhang,P., Shi,H.H., Nelson,R.D., Kishore,B.K. Chronic dDAVP infusion in rats decreases the expression of P2Y2 receptor in inner medulla and P2Y2 receptor-mediated PGE2 release by IMCD. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F768-F776. >>> Vasopressin, 1-deamino-8-D-arginine; Saline, sterile; SC; Rat; 2002; 5, 6 days; Controls received mp w/ vehicle; dose-response (figs. 8, 9); animal info (male, Sprague-Dawley 309 g); agent also known as dDAVP or desmopressin.

P7153 Vagnes,O.B., Hansen,F.H., Feng,J.J., Iversen,B.M., Arendshorst,W.J. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. American Journal of Physiology-Renal Physiology 2005; 288(-6-):F1249-F1256. >>> Vasopressin, arginine; Saline; SC; Rat; 2001; 6 days; Controls received mp w/ vehicle; cardiovascular; AVP.

P6383 Kim,D.G., Sands,J.M., Klein,J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F760-F766. >>> Vasopressin; Saline; SC; Rat; 2002; 5,12 days; Functionality of mp verified by urine osmolality; diabetes.

P6642 Lim,S.W., Li,C., Sun,B.K., Han,K.H., Kim,W.Y., Oh,Y.W., Lee,J.U., Kador,P.F., Knepper,M.A., Sands,J.M., Kim,J., Yang,C.W. Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney. American Journal of Physiology-Renal Physiology 2004; 287(-1-):F139-F151. >>> Vasopressin, 1-desamino-8-D arginine; Sodium Chloride; SC; Rat; 2ML1; 7 days.

P6467 Loyher,M.L., Mutin,M., Woo,S.K., Kwon,H.M., Tappaz,M.L. Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neuroscience 2004; 124(-1-):89-104. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2002; 7 days; Controls received sham treatment.

P6443 Massieu,L., Montiel,T., Robles,G., Quesada,O. Brain amino acids during hyponatremia in vivo: Clinical observations and experimental studies. Neurochemical Research 2004; 29(-1-):73-81. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2001; 7 days; Vasopressin, 1-desamino-8-D arginine plasma levels taken.

P6693 van Balkom,B.W.M., Hoffert,J.D., Chou,C.L., Knepper,M.A. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. American Journal of Physiology-Renal Physiology 2004; 286(-2-):F216-F224. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2001; 72 hours; Controls received mp w/ vehicle.

P6360 Windle,R.J., Kershaw,Y.M., Shanks,N., Wood,S.A., Lightman,S.L., Ingram,C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. Journal of Neuroscience 2004; 24(-12-):2974-2982. >>> Oxytocin; vasopressin; Saline; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit; peptides; dental cement used.

P6561 Zhang,M.Z., Lopez,P.S., McKanna,J.A., Harris,R.C. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology 2004; 145(-3-):1402-1409. >>> Vasopressin, arginine-8-; Vasopressin, 1-desamino-8-D arginine; PV-OT; D3PVP; Water, distilled; SC; Rat; 2002; 6 days; Controls received mp w/ vehicle; replacement therapy (hypophysectomy); dose-response (table 1); comparison of IM or IP injections vs. mp; PV-OT is a V1a receptor agonist, D3PVP is a Vlb receptor agonist; dDVAP is a V2 receptor agonist.

P5786 Bardoux,P., Bichet,D.G., Martin,H., Gallois,Y., Marre,M., Arthus,M.F., Lonergan,M., Ruel,N., Bouby,N., Bankir,L. Vasopressin increases urinary albumin excretion in rats and humans: involvement of V-2 receptors and the renin-angiotensin system. NEPHROLOGY DIALYSIS TRANSPLANTATION 2003; 18(-3-):497-506. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; 2001; 1 week; Comparison of acute IP injections chronic vs. mp.

P6704 Brooks,H.L., Ageloff,S., Kwon,T.H., Brandt,W., Terris,J.M., Seth,A., Michea,L., Nielsen,S., Fenton,R., Knepper,M.A. cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F218-F228. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; SC; Rat; 2001; 7 days; 4, 72 hours; Controls received mp w/ vehicle.

P5748 Christensen,B.M., Wang,W.D., Frokiaer,J., Nielsen,S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. American Journal of Physiology-Renal Physiology 2003; 284(-4-):F701-F717. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 6 days; Controls received mp w/ vehicle; peptides; Vasopressin, 1-desamino-8-D arginine (1-deamino-(8-D-arginine)-vasopressin) is a V2 selective vasopressin agonist.

P6587 Combet,S., Geffroy,N., Berthonaud,V., Dick,B., Teillet,L., Verbavatz,J.M., Corman,B., Trinh-Trang-Tan,M.M. Correction of age-related polyuria by Vasopressin, 1-desamino-8-D arginine: molecular analysis of aqu aporins and urea transporters. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F199-F208. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; 6 days; Controls received mp w/ saline; dose-response (p. F201); no stress (see pg.F201); peptides.

R0215 Ishikawa,S., Schrier,R.W. Pathophysiological roles of arginine vasopressin and aquaporin-2 in im paired water excretion. Clinical Endocrinology 2003; 58(-1-):1-17. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 14 days; Peptides; ALZET pumps mentioned on pg. 3 and 10.

P6005 Michimata,M., Mizukami,K., Suzuki,M., Kazama,I., Nakamura,Y., Suzuki,K., Yanagisawa,T., Imai,Y., Sasaki,S., Matsubara,M. Vasopressin-independent renal urinary concentration: Increased rBSC1 and enhanced countercurrent multiplication. Kidney International 2003; 64(-3-):933-938. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; 3 days; Vasopressin, 1-desamino-8-D arginine is desmopressin acetate.

P5994 Murase,T., Tian,Y., Fang,X.Y., Verbalis,J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; 5 days; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

P5636 Somponpun,S.J., Sladek,C.D. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Journal of Neuroscience 2003; 23(-10-):4261-4269. >>> Vasopressin, arginine; Saline; IP; Rat; ; Controls received mp w/ vehicle.

P5079 Silver,S.M., Schroeder,B.M., Sterns,R.H. Brain uptake of myoinositol after exogenous administration. Journal of the American Society of Nephrology 2002; 13(--):1255-1260. >>> Vasopressin; SC; rat; 3 days; controls received mp w/ vehicle; peptides; synthetic vasopressin; chronic vasopressin induced hyponatremia; plasma sodium levels checked..

P5082 Soupart,A., Silver,S., Schroeder,B., Sterns,R., Decaux,G. Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. Journal of the American Society of Nephrology 2002; 13(--):1433-1441. >>> Vasopressin, arginine-8-; SC; rat; 2001; 3 days; Vasopressin induced hyponatremia; serum sodium levels checked.

P5413 Trinh-Trang-Tan,M.M., Lasbennes,F., Gane,P., Roudier,N., Ripoche,P., Cartron,J.P., Bailly,P. UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney. Am.J.Physiol Renal Physiol 2002/11; 283(-5-):F912-F922. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; IP; Rat; 6-7 days; Controls received mp w/ vehicle; synthetic selective V2 Vasopressin Agonist.

P4697 Ecelbarger,C.A, Kim,G.-H, Knepper,M.A, Liu,J, Tate,M, Welling,P.A, Wade,J.B  J.Am.Soc.Nephrol. 2001; 12(--):10-18. >>> Vasopressin, 1-desamino-8-D arginine;; Saline;; rat;; 2001;; 7 days;; Controls received mp w/ vehicle; peptides; Barttner's Disease; d-DAVP is 1-deamino-(8-D-arginine)-vasopressin;.

P4896 Ecelbarger,C.A., Knepper,M.A., Verbalis,J.G. Increased abundance of distal sodium transporters in rat kidney during vasopressin escape. Journal of the American Society of Nephrology 2001; 12(--):207-217. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 2002; 7-11 days; peptides; Vasopressin, 1-desamino-8-D arginine is a V2 selective vasopressin agonist;.

P5026 Leng,G., Brown,C.H., Bull,P.M., Brown,D., Scullion,S., Currie,J., Blackburn-Munro,R.E., Feng,J.F., Onaka,T., Verbalis,J.G., Russell,J.A., Ludwig,M. Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: An experimental and theoretical analysis. Journal of Neuroscience 2001; 21(-17-):6967-6977. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 5-14 days; functionality of mp verified by plasma sodium levels; peptides; Vasopressin, 1-desamino-8-D arginine is an arginine vasopressin V2-receptor agonist that causes hyponatremia..

P4860 Glasgow,E., Murase,T., Zhang,B.J., Verbalis,J.G., Gainer,H. Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2000; 279(--):R1239-R1250. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2002; 7 days; functionality of mp verified by plasma sodium levels; dose response (table 1 p. R1240); peptides; Vasopressin, 1-desamino-8-D arginine induced hyponatremia.

P4443 Wade,J.B, Lee,A.J, Liu,J, Ecelbarger,C.A, Mitchell,C, Bradford,A.D, Terris,J, Kim,G.-H, Knepper,M.A  Am.J.Physiological.Renal Physiol. 2000; 278(--):F52-F62. >>> Vasopressin, 1-desamino-8-D arginine; Saline;; SC;; rat;; 2002;; 7 days;; controls received mp w/vehicle; peptides;.

P4449 Kim,G.H, Ecelbarger,C.A, Mitchell,C, Packer,R.K, Wade,J.B, Knepper,M.A  Am.J.Physiol.(Renal Physiol.45) 1999; 276(--):F96-F103. >>> Vasopressin, 1-desamino-8-D arginine;; Saline;; SC;; rat;; 2002;; 7 days;; controls received mp w/vehicle; peptides;.

P4431 Kwon,T-H, Frokiaer,J, Fernandez-Llama,P, Maunsbach,A.B, Knepper,M.A, Nielsen,S  Am.J.Physiol.(Renal Physiol.46) 1999; 277(--):F257-F270. >>> Vasopressin, 1-desamino-8-D arginine;; NaCl; Dextrose; Acetic acid;; SC;; rat;; 2002;; 7days;; controls received mp w/saline; functionality of mp verified by plasma levels; peptides;.

P4069 Cordoba,J., Gottstein,J., Blei,A.T. Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. J.Hepatol. 1998; 29(--):589-594. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2002; 7 days; controls received mp w/vehicle; no stress (see p. 591); peptides.

P4500 Ecelbarger,C.A, Chou,C-L, Lee,A.J, DiGiovanni,S.R., Verbalis,G.J., Knepper,M.A  Am.J.Physiol.(Renal Physiol.43) 1998; 274(--):F1161-F1166. >>> Vasopressin, 1-desamino-8-D arginine; SC;; rat;; 2002;; 4 days;; peptides;.

P4072 Harada,K., Ogura,T., Yamauchi,T., Otsuka,F., Mimura,Y., Hashimoto,M., Oishi,T., Makino,H. Effect of continuous infusion of vasopressin on glomerular growth response in spontaneously hypertensive rats. Regul.Pept. 1998; 74(--):11-18. >>> Vasopressin, arginine; Ringer's solution, lactated; SC; rat; 15 days; controls received mp w/vehicle; cardiovascular; peptides.

P4076 Kjoer,A., Knigge,U., Jorgensen,H., Warberg,J. Selective inhibition of magnocellular vasopressin neurons by hypoosmolality: effect on histamine- and stress-induced secretion of adrenocorticotropin and prolactin. Neuroendocrinology 1998; 67(--):330-335. >>> Vasopressin, 1-desamino-8-D arginine; Acetic acid; SC; rat; 2002; 9 days; controls received mp w/vehicle; functionality of mp verified by measuring residual reservoir volume; vasopressin 2 receptor antagonist.

P4464 Kwon,T.H, Frokiaer,J, Knepper,M.A, Nielsen,S  Am.J.Physiol.(Renal Physiol.44) 1998; 275(--):F724-F741. >>> Vasopressin, 1-desamino-8-D arginine; Saline; Dextrose; acetic acid;; SC;; rat;; 2002;; 7 days;; controls received mp w/saline + sham surgery;.

P4156 McBroom,M.J., Qureshi,A., Davidson,N. Antidiuretic hormone infusion reduces taurine and NaCl-induced hypernatremia in the rat. Amino Acids 1998; 15(--):89-97. >>> Vasopressin, arginine; Water, distilled; SC; rat; 2001; 8 days; controls received mp w/vehicle; peptides.

P4521 Terris,J, Ecelbarger,C.A, Sands,J.M, Knepper,M.A  Journal of the American Society of Nephrology 1998/5; 9(--):729-736. >>> Vasopressin, arginine; Furosemide;; Dextrose; Acetic acid; Sodium Chloride;; rat;; 2002;; 5 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides;.

P3813 Everts,H.G.J., Koolhaas,J.M. Lateral septal vasopressin in rats: role in social and object recognition?. Brain Research 1997; 760(--):1-7. >>> Vasopressin antagonist; CSN/CNS (lateral septum); rat; 2002; 2 weeks; controls received mp w/saline; 2 pumps and 2 brain cannulae implanted per animal; cannulae placed in animals 6 days before pumps to allow for recovery.

P3565 Bouby,N., Ahloulay,M., Nsegbe,E., Deschaux,M., Schmitt,F., Bankir,L. Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action. J.Am.Soc.Nephrol. 1996; 7(--):842-851. >>> Vasopressin, 1-desamino-8-D arginine; Inulin; 14C tracer; Radio-isotopes; IP; rat; 2001; 7 days; no comment posted.

P4049 Kishore,B.K., Terris,J.M., Knepper,M.A. Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP. Am.J.Physiol.(Renal Fluid Electrolyte Physiol.40) 1996; 271(--):F62-F70. >>> Vasopressin; Arginine; Dextrose solution; Water; Acetic acid; SC; rat; 2002; 1, 3, 5, 14 days; peptides.

P3358 Makara,G.B., Kiss,A., Lolait,S.J., Aguilera,G. Hypothalamic-pituitary corticotroph function after shunting of magnocellular vasopressin and oxytocin to the hypophyseal portal circulation. Endocrinology 1996; 137(-2-):580-586. >>> Vasopressin, desamino- [D-Arg8]-; SC; rat; 2001; 5 days; controls received silastic tubing.

P4073 Stoynev,A.G., Nagai,K. Lack of effect of suprachiasmatic infusion of a vasopressin antagonist on the circadian rhythm of wheel-running activity in rats. Acta Physiol.Pharmacol.Bulg. 1996; 22(--):39-43. >>> Vasopressin, (Pmp1, Tyr (Me)2)-Arg8; CSF/CNS (suprachiasmatic nucleus); rat; 2001; 8 days; vasopressin antagonist; peptides.

P2967 Adler,S., Verbalis,G.J., Williams,D. Effect of rapid correction of hyponatremia on the blood-brain barrier of rats. Brain Research 1995; 679(--):135-143. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 1,2,7&14 days; controls received mp with isotonic NaCI.

P8223 DiGiovanni,S.R., Nielsen,S., Christensen,E.I., Knepper,M.A. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc.Natl.Acad.Sci.U.S.A 1994/9/13; 91(-19-):8984-8988. >>> Vasopressin, arginine 8; Water; dextrose; acetic acid; SC; Rat; 5-6 days; Controls received mp w/ vehicle; animal info (male, Brattleboro di/di, 6-10 weeks old).

P2984 Evans,D.A.P., Van Der Kleij,A.A.M., Sonnemans,M.A.F., Burbach,J.P.H., Van Leeuwen,F.W. Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons. Proc.Natl.Acad.Sci.USA 1994; 91(--):6059-6063. >>> Vasopressin; SC; rat; 2ML4; 40 weeks; controls received a tube similar in size to mp and were sham operated every 28 days; replacement therapy (genetic -- homozygous(di/di) -- inability to produce vasopressin); long-term study, pumps replaced every 28 days.

P3110 Tsuboi,Y., Ishikawa,S., Fujisawa,G., Okada,K., Saito,T. In vivo diuretic effect of a new non-peptide arginine vasopressin antagonist, OPC-31260, in conscious rats. J.Endocrinol. 1994; 143(--):227-234. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2001; no duration posted; controls received mp with vehicle.

P2600 Allen,D.E., Gellai,M. Mechanisms for the diuresis of acute cold exposure: role for vasopressin?. Am.J.Physiol. 1993; 264(-33-):R524-R532. >>> Vasopressin, arginine; Acetic acid; Ringer's solution, lactated; SC; rat; 2002; 14 days; peptides.

P2608 Allen,D.E., Gellai,M. a2-Adrenoceptor antagonism attenuates the diuretic response to acute cold exposure. Am.J.Physiol. 1993; 265(-34-):R689-R696. >>> Vasopressin, arginine; Acetic acid; Ringer's solution, lactated; SC; rat; 2002; no duration posted; peptides.

P2205 Fujisawa,G., Ishikawa,S.-E., Tsuboi,Y., Okada,K., Saito,T. Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats. Kidney Int. 1993; 44(--):19-23. >>> Vasopressin, 1-deamino-8-D-arginine; Sodium chloride; SC; rat; 2002; 14 days; controls received vehicle in mp; OPC-31260 was given orally.

P3197 Hauger,R.L., Aguilera,G. Regulation of pituitary corticotropin releasing hormone (CRH) receptors by CRH: interaction with vasopressin. Endocrinology 1993; 133(--):1708-1714. >>> Corticotropin-rel. factor; Vasopressin; Vasopressin antagonist; SC; rat; 2001; 48 hours; controls received inactive mp or silastic tubing; peptides; the vasopressin antagonist was (mercapto cyclopenta-methylene propionic acid)-[methyl-tyrosine]arginine VP; agents given singly or together.

P3108 Tsuchihashi,T., Takata,Y., Nakao,Y., Tominaga,M., Takishita,S., Kobayashi,K., Abe,I., Fujishima,M. Haemodynamic and humoral consequences of chronic infusion of vasopressin in conscious rats. Clin.Exp.Pharmacol.Physiol. 1993; 20(--):489-495. >>> Vasopressin, arginine; Saline; IV (jugular); rat; 2001; 7 days; controls received mp with vehicle; peptides.

P2518 Verbalis,J.G., Gullans,S.R. Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. Brain Research 1993; 606(--):19-27. >>> Vasopressin, 1-deamino-8-D-arginine; SC; rat; 2002; 14 days; functionality of mp verified by plasma Na levels; dose-response (pg. 20 plasma).

P8043 Winslow,J.T., Hastings,N., Carter,C.S., Harbaugh,C.R., Insel,T.R. A role for central vasopressin in pair bonding in monogamous prairie voles. Nature 1993/10/7; 365(-6446-):545-548. >>> Vasopressin, arginine; oxytocin; CSF; CSF/CNS; Prairie vole; 48 hours; Controls received mp w/ vehicle; cannula secured w/ dental cement.