References on the Administration of Vascular Endothelial Factor Using ALZET® Osmotic Pumps

16221 Oller, J., Alfranca, A., Mendez-Barbero, N., Villahoz, S., Lozano-Vidal, N., Martin-Alonso, M., Arroyo, A. G., Escolano, A., Armesilla, A. L., Campanero, M. R., Redondo, J. M. C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol 2015; 35(-19-):3409-22. >>> Vascular Endothelial Growth Factor, Angiotensin II, Losartan, Cyclosporine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (Calcineurin (CN) B1 (Cnb1_/fl) conditional knockout mice, C57BL/6 mice); dose-response; vegf aka vascular endothelial growth factor; Dose (VEGF 25 ug/kg/day, AngII 1 ug/kg/min, CsA 5 mg/kg/day, Losartan 10 mg/kg/day);.

16166 Rhee, Y. H., Yi, S. H., Kim, J. Y., Chang, M. Y., Jo, A. Y., Kim, J., Park, C. H., Cho, J. Y., Choi, Y. J., Sun, W., Lee, S. H. Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Sci Rep 2016; 6(--):32025. >>> Raf-Transducer cells, conditioned media; leukemia inhibitory factor; fibroblast growth factor 2; vascular endothelial growth factor; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle or control media; animal info (male, C57Bl6, 50-100g); ALZET brain infusion kit 2 used; immunology; cyanoacrylate adhesive; Brain coordinates;.

15103 Taylor, S.L., Trudeau, D., Arnold, B., Wang, J.S., Gerrow, K., Summerfeldt, K., Holmes, A., Zamani, A., Brocardo, P.S., Brown, C.E., Brown, C.E. VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes. NEUROBIOLOGY OF DISEASE 2015; 78(--):1-11. >>> Vascular endothelial growth factor (165); CSF, artificial; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, C57BL6J, 2 months old); ALZET brain infusion kit 3 used; behavioral testing (Morris water maze); diabetes;.

14689 Chehrehasa, F., Cobcroft, M., Young, Y.W., kay-Sim, A., Goss, B., kay-Sim, A. An Acute Growth Factor Treatment that Preserves Function after Spinal Cord Contusion Injury. Journal of Neurotrauma 2014; 31(--):1807-1813. >>> Vascular endothelial growth factor; platelet-derived growth factor-BB; PBS; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ saline; animal info (female, Wistar, 20-25 weeks, 300g); spinal cord injury; post op. care (cephalothin; buprenorphine; manual bowel and bladder expression BID); behavioral testing (locomotor behavior; gaid and footprint analysis); used Rat intrathecal catheter; pumps primed in 37C saline overnight;.

13648 Lassaletta, A.D., Elmadhun, N.Y., Burgess, T.A., Bianchi, C., Sabe, A.A., Robich, M.P., Chu, L.M., Sellke, F.W. Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. CIRCULATION JOURNAL 2014; 78(-3-):743-751. >>> Vascular endothelial growth factor, recombinant human; Heparin; Saline; Intrapericardial; Pig; 2ML4; Animal info (male, Yorkshire miniswine, 13-22kg); ischemia (cardiac, chronic); stress/adverse reaction: (see pg. 746); post op. care (Enrofloxacin 68mg PO daily for 5 days; aspirin 325 mg/day for 5 days; buprenorphine HCL 0.3 mg/kg, transdermal fentanyl patch 4mcg/kg for 72h); cardiovascular;.

13277 Shim, J.W., Sandlund, J., Han, C.H., Hameed, M.Q., Connors, S., Klagsbrun, M., Madsen, J.R., Irwin, N. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Experimental Neurology 2013; 247(-;-):703-709. >>> Vascular endothelial growth factor-A165; Bevacizumab; Saline; BSA; CSF/CNS; Rat; 2001D; Controls received mp w/vehicle, or (saline, BSA); Peptides; animal info (male Sprague-Dawley rats, 250g); Brain infusion kit (2) used;.

13167 Zechariah, A., ElAli, A., Doeppner, T.R., Jin, F.Y., Hasan, M.R., Helfrich, I., Mies, G., Hermann, D.M. Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra. Stroke 2013; 44(-6-):1690-U393. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 2004; Controls received mp w/ saline; animal info (male C57BL6/j, 20-25g); ischemia.

13118 Wang, L., Wang, X., Wang, L., Chiu, J.D., van de Ven, G., Gaarde, W.A., DeLeve, L.D. Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells. Gastroenterology 2012; 143(-6-):1555-U239. >>> Vascular endothelial growth factor; IP; Rat; Animal info (Lewis, VEGF KO, hepatectomy); infusion rate of 1 ul/hr.

12897 Siddiqui, A.H., Irani, R.A., Zhang, W.R., Wang, W., Blackwell, S.C., Kellems, R.E., Xia, Y. Angiotensin Receptor Agonistic Autoantibody-Mediated Soluble Fms-Like Tyrosine Kinase-1 Induction Contributes to Impaired Adrenal Vasculature and Decreased Aldosterone Production in Preeclampsia. Hypertension 2013; 61(-2-):472-U526. >>> Vascular endothelial growth factor, 121; Mice (pregnant); Animal info (C57BL/6).

12879 Shan, L., Yong, H.M., Song, Q., Wei, Y., Qin, R., Zhang, G.H., Xu, M.Y., Zhang, S.H. Vascular endothelial growth factor B prevents the shift in the ocular dominance distribution of visual cortical neurons in monocularly deprived rats. Experimental Eye Research 2013; 109(-;-):17-21. >>> Vascular endothelial growth factor B; CSF, artificial; CSF/CNS; Rat; 1007D; Control animals received mp w/ vehicle; animal info (Long Evans hooded); PE60 tubing used.

12754 Xiao, X.W., Guo, P., Chen, Z., El-Gohary, Y., Wiersch, J., Gaffar, I., Prasadan, K., Shiota, C., Gittes, G.K. Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass. Journal of Biological Chemistry 2013; 288(-12-):8636-8646. >>> Vascular endothelial growth factor, A; Mice; 2004; Animal info (C57BL/6, MIP-GFP, male, 8 wks old);.

12602 Argandona, E.G., Bengoetxea, H., Bulnes, S., Rico-Barrio, I., Ortuzar, N., Lafuente, J.V. Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex. Brain Research 2012; 1473(-;-):141-154. >>> Vascular endothelial growth factor; anti-VEGF; PBS; CSF/CNS (cortex); Rat; 1007D; Control animals received mp w/ vehicle; animal info (Long Evans, P18); ALZET brain infusion kit used; cyanoacrylate adhesive used.

12487 Mateus, J., Bytautiene, E., Lu, F.X., Tamayo, E.H., Betancourt, A., Hankins, G.D.V., Longo, M., Saade, G.R. Endothelial growth factor therapy improves preeclampsia-like manifestations in a murine model induced by overexpression of sVEGFR-1. American Journal of Physiology-Heart and Circulatory Physiology 2011; 301(-5-):H1781-H1787. >>> Vascular endothelial growth factor 121; PBS; SC; Mice (pregnant); 2002; Controls received mp w/ vehicle; animal info (CD-1); functionality of mp verified by residual volume and plasma drug levels.

12090 Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., Leker, R.R. SUBACUTE TREATMENT WITH VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER TRAUMATIC BRAIN INJURY INCREASES ANGIOGENESIS AND GLIOGENESIS. Neuroscience 2012; 202(-;-):334-341. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; Controls received mp w/ vehicle; animal info (adult, Sabra, 40 g).

12081 Herz, J., Reitmeir, R., Hagen, S.I., Reinboth, B.S., Guo, Z.Y., Zechariah, A., ElAli, A., Doeppner, T.R., Bacigaluppi, M., Pluchino, S., Kilic, U., Kilic, E., Hermann, D.M. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions. NEUROBIOLOGY OF DISEASE 2012; 45(-3-):1077-1085. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS; Mice; 2002; 2004; Controls received mp w/ saline; animal info (male, C57BL/6J, 8-10 wks old, 23-25 g); ischemia.

12046 Lutton, C., Young, Y.W., Williams, R., Meedeniya, A.C.B., kay-Sim, A., Goss, B. Combined VEGF and PDGF Treatment Reduces Secondary Degeneration after Spinal Cord Injury. Journal of Neurotrauma 2012; 29(-5-):957-U479. >>> Vascular endothelial growth factor; platelet-derived growth factor; Saline; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (Wistar, male, adult, 300 g, 20-25 wks old); functionality of mp verified in vitro;"catheter was... sutured to the muscle to keep it in place"pg 959.

11935 Chu, L.M., Robich, M.P., Lassaletta, A.D., Feng, J., Laham, R.J., Burgess, T., Clements, R.T., Sellke, F.W. Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia. Surgery 2011; 150(-3-):390-399. >>> Vascular endothelial growth factor, recomb. human; Intrapericardial; Pig; Animal info (intact, male, Yorkshire); stress/adverse effects"sudden cardiac death", pg 393.

11926 Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., Leker, R.R. Combination of Vascular Endothelial and Fibroblast Growth Factor 2 for Induction of Neurogenesis and Angiogenesis after Traumatic Brain Injury. Journal of Molecular Neuroscience 2012; 47(-1-):166-172. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, Sabra, adult, 40 g).

11891 Reitmeir, R., Kilic, E., Reinboth, B.S., Guo, Z.Y., ElAli, A., Zechariah, A., Kilic, U., Hermann, D.M. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta Neuropathologica 2012; 123(-2-):273-284. >>> Vascular endothelial growth factor; NaCl; CSF/CNS; Mice; 2002; 2004; Controls received mp w/ vehicle; animal info (male, C57Bl6/j, 8-10 wks old, 23-25 g); ischemia (MCAO); stress/adverse effects,"complications related to pump insertion"pg 274; behavioral testing (Rotarod, grip strength test).

11863 Romo, L.B., Tapia, R. VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK. Journal of Neurochemistry 2010; 115(-5-):1090-1101. >>> Isoxazolepropionate, alpha amino-3-hydroxy-5-; vascular endothelial growth factor, recomb., 164; SU14980, tyrphostin; LY294002; wortmannin; PD-98059; SB203580; neurodegenerative (amyotrophic lateral sclerosis);; PBS; DMSO; CSF/CNS (intrathecal, spinal cord); Rat; 2004; Controls received mp w/ vehicle; animal info (Wistar, male, 270-290 g, adult); alpha amino-3-hydroxy-5-isoxazolepropionate also known as AMPA; wound clips used; post op. care, pg 1091 (penicillin); good methods, pg 1091; multiple pumps used (2); multiple intrathecal catheters used; wound clips used; 2% DMSO used; enzyme inhibitor (p38 mitogen-activated protein kinase, p38MAPK).

11626 Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., Leker, R.R. Vascular endothelial growth factor increases neurogenesis after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 2010; 30(-5-):1008-1016. >>> Vascular endothelial growth factor; CSF/CNS; Mice; Controls received mp w/ vehicle or were sham operated; animal info (adult, Sabra, male, 40 g); infusion rate of 0.5 ul/hr.

11618 Siddiqui, A.H., Irani, R.A., Zhang, Y.J., Dai, Y.B., Blackwell, S.C., Ramin, S.M., Kellems, R.E., Xia, Y. Recombinant Vascular Endothelial Growth Factor 121 Attenuates Autoantibody-Induced Features of Pre-eclampsia in Pregnant Mice. American Journal of Hypertension 2011; 24(-5-):606-612. >>> Vascular endothelial growth factor 121; SC; Mice (pregnant); 1007D; Animal info (C57BL/6, 8 wks old).

11507 Miyasaka, E.A., Raghavan, S., Gilmont, R.R., Mittal, K., Somara, S., Bitar, K.N., Teitelbaum, D.H. In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival. PEDIATRIC SURGERY INTERNATIONAL 2011; 27(-2-):137-143. >>> Fibroblast growth factor-2; vascular endothelial growth factor-2; platelet-derived growth factor; SC; Mice; 1004; Controls received mp with no growth factors; animal info (C57BL/6); good methods, pg 138; tissue perfusion (internal anal sphincter); silicone catheter used;"the osmotic pumps we used completed delivery of the growth factors by 28 days, which would clearly limit the duration of exposure to the growth factor, lessening the risk of malignancy"pg 143.

11468 Lee, C., Agoston, D.V. Vascular Endothelial Growth Factor Is Involved in Mediating Increased De Novo Hippocampal Neurogenesis in Response to Traumatic Brain Injury. Journal of Neurotrauma 2010; 27(-3-):541-553. >>> Vascular endothelial growth factor 164; SU5416; uridine, bromodeoxy; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (young, Sprague Dawley, male, 270-300 g); 1% DMSO used.

11129 Ortuzar, N., Argandona, E.G., Bengoetxea, H., Lafuente, J.V. Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats. Journal of Neural Transmission 2011; 118(-1-):135-144. >>> Vascular endothelial growth factor; CSF/CNS (cortex); Rat; 1007D; Controls received mp w/ PBS or no implantation; animal info (Long-Evans, P18); cyanoacrylate adhesive; ALZET brain infusion kit 3 used;"Total operating time was approximately 25 min."pg 137.

10961 Nicoletti, J.N., Lenzer, J., Salerni, E.A., Shah, S.K., Elkady, A., Khalid, S., Quinteros, D., Rotella, F., Betancourth, D., Croll, S.D. Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats. EPILEPSY&BEHAVIOR 2010; 19(-3-):272-277. >>> Vascular endothelial growth factor, 165, recomb. human; vascular endothelial growth factor, inactivated; PBS, sterile; CSF/CNS (hippocampus); Rat; 2002; Controls received no surgical manipulations or protein infusions; animal info (male Sprague-Dawley, 250-350 g); behavioral testing (Morris water maze, Grid locomotor activity, Light-dark exploration).

10649 Bogaert, E., Van Damme, P., Poesen, K., Dhondt, J., Hersmus, N., Kiraly, D., Scheveneels, W., Robberecht, W., Van den Bosch, L. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. NEUROBIOLOGY OF AGING 2010; 31(-12-):2185-2191. >>> Vascular endothelial growth factor; CSF/CNS; Rat; 2004; Controls received mp w/ vehicle; animal info (80 days old).

10603 Ahmed, A., Singh, J., Khan, Y., Seshan, S.V., Girardi, G. A New Mouse Model to Explore Therapies for Preeclampsia. PLoS One 2010; 5(-10-):U325-U333. >>> Vascular endothelial growth factor (121); PBS, sterile; SC; Mice; Animal info (CBA/J x DBA/2 and CBA/J x BALB/c).


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“The implanted pumps offered an advantageous alternative to repeated injections. During drug delivery, no external connection was required, and rats were untethered and unrestrained, thereby minimizing animal handling stress” Zhang et al., Journal of Neurophysiology 2000;84:798-805.