References on the Administration of Vitamins Using ALZET® Osmotic Pumps

1. RO-23-7553

3818 Light, B.W., Yu, W.-D., McElwain, M.C., Russell, D.M., Trump, D.L., Johnson, C.S. Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res 1997; 57(--):3759-3764. >>> RO-23-7553; PBS; IP; mice; 1007D; controls received sham mp; cancer.

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2. Vitamin A

7460 Liu, T., Bohlken, A., Kuljaca, S., Lee, M., Nguyen, T., Smith, S., Cheung, B., Norris, M.D., Haber, M., Holloway, A.J., Bowtell, D.D.L., Marshall, G.M. The retinoid anticancer signal: mechanisms of target gene regulation. British Journal of Cancer 2005; 93(-3-):310-318. >>> Retinoic acid, 13-cis-; Ethanol; SC; Mice (transgenic); 1007D; Controls received mp w/ vehicle; dose-response (fig. 1); no stress (see pg. 312-13); cancer (neuroblastoma).

7442 Karam, S.M., John, R., Alpers, D.H., Ponery, A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

4849 Kopke, R.D, Jackson, R.L, Li, G, Rasmussen, M.D, Hoffer, M.E, Frenz, D.A, Costello, M, Schultheiss, P, Van De Water, T.R. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function.. PNAS 2001; 98(-10-):5886-5891. >>> Transforming growth factor; insulin-like growth factor I; retinoic acid; brain-derived neurotrophic factor;; PBS; BSA;; Ear (vestibule); Guinea-pig; 2002; Controls received mp w/ vehicle; pumps replaced after 2 weeks; peptides; IntraEAR catheter used; GFI group pumps filled with TGF, IGF and Retinoic acid; GFII group pumps filled with TGF, IGF, BDNF and retinoic acid; tissue perfusion (vestibule).

15534 Rodgers, K.E., Girgis, W., Amand, K.St., Campeau, J.D., diZerega, G.S. Reduction of adhesion formation by intraperitoneal administration of various anti-inflammatory agents. J. Invest. Surgery 1998; 11(--):327-339. >>> Retinoic acid; Quinacrine; Dipyridamole; PBS; Ethanol; injury site; rabbit; 2ML1; controls received mp w/vehicle; tissue perfusion (surgical injury site); animals given morphine i.m. for post-operative pain; catheter stabilized in sidewall w/suture; in some studies, catheter tubing was disconnected to halt flow at specific times; immunology.

4123 Rodgers, K.E., Girgis, W., Amand, K.St., Campeau, J.D., diZerega, G.S. Reduction of adhesion formation by intraperitoneal administration of various anti-inflammatory agents. J. Invest. Surgery 1998; 11(--):327-339. >>> Retinoic acid; Quinacrine; Dipyridamole; PBS; Ethanol; injury site; rabbit; 2ML1; controls received mp w/vehicle; tissue perfusion (surgical injury site); animals given morphine i.m. for post-operative pain; catheter stabilized in sidewall w/suture; in some studies, catheter tubing was disconnected to halt flow at specific times; immunology.

3599 Kaya, M., Chang, L., Truong, A., Brightman, M.W. Chemical induction of fenestrae in vessels of the blood-brain barrier. Exp. Neurol 1996; 142(--):6-13. >>> Retinoic acid; Phorbol myristate acetate; ETOH; Gibco BRL minimal essential medium; DMSO; Culture medium, serum-free; CSF/CNS (cortex); rat; 2ML1; controls received mp w/ vehicle; functionality of mp verified by residual volume; pumps replaced weekly.

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3. Vitamin B

15939 Mutti, E., Ruetz, M., Birn, H., Krautler, B., Nexo, E. 4-ethylphenyl-cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12 deficiency in mice. PLoS One 2013; 8(-9-):e75312. >>> Vitamin b12; Cobalamin, ethylphenyl-; saline; SC; mice; 2004; controls received mp w saline; animal info: 7 wks old, female, strain 129.S6; mp used to infuse EtPhCbI in mice to see if it causes Cbl (cobalamin) deficiency; EtPhCbl (3.5 nmol/24 h), CNCbI.

12716 Lildballe, D.L., Mutti, E., Birn, H., Nexo, E. Maximal Load of the Vitamin B12 Transport System: A Study on Mice Treated for Four Weeks with High-Dose Vitamin B12 or Cobinamide. PLoS One 2012; 7(-10-):U386-U392. >>> Cobinamide; vitamin B12; Saline; SC; Mice; 2004; Control animals received mp w/ vehicle; animal info (129.S6, 8 wks old, female);"To avoid wound biting between mice, the mice were housed in individual cages for 3 days after surgery."; post op. care (buprenorphine in the water); cobinamide is a vitamin B12 analogue.

3875 Kiuchi, T., Sei, H., Seno, H., Sano, A., Morita, Y. Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat. Physiol. Behav 1997; 61(-4-):551-554. >>> Vitamin B12; IP; rat; 2002; controls received mp w/saline.

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4. Vitamin B12

15939 Mutti, E., Ruetz, M., Birn, H., Krautler, B., Nexo, E. 4-ethylphenyl-cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12 deficiency in mice. PLoS One 2013; 8(-9-):e75312. >>> Vitamin b12; Cobalamin, ethylphenyl-; saline; SC; mice; 2004; controls received mp w saline; animal info: 7 wks old, female, strain 129.S6; mp used to infuse EtPhCbI in mice to see if it causes Cbl (cobalamin) deficiency; EtPhCbl (3.5 nmol/24 h), CNCbI.

12716 Lildballe, D.L., Mutti, E., Birn, H., Nexo, E. Maximal Load of the Vitamin B12 Transport System: A Study on Mice Treated for Four Weeks with High-Dose Vitamin B12 or Cobinamide. PLoS One 2012; 7(-10-):U386-U392. >>> Cobinamide; vitamin B12; Saline; SC; Mice; 2004; Control animals received mp w/ vehicle; animal info (129.S6, 8 wks old, female);"To avoid wound biting between mice, the mice were housed in individual cages for 3 days after surgery."; post op. care (buprenorphine in the water); cobinamide is a vitamin B12 analogue.

3875 Kiuchi, T., Sei, H., Seno, H., Sano, A., Morita, Y. Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat. Physiol. Behav 1997; 61(-4-):551-554. >>> Vitamin B12; IP; rat; 2002; controls received mp w/saline.

1821 Brass, E.P., Allen, R.H., Ruff, L.J., Stabler, S. Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat. Biochem. J 1990; 226(--):809-815. >>> Vitamin B12 analog; SC; rat; 2002; controls received pumps with saline only; pumps replaced after three weeks; cobalamin analog.

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5. Vitamin B12 Analog

P1825 Brass,E.P., Allen,R.H., Ruff,L.J., Stabler,S. Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat. Biochem.J. 1990; 226(--):809-815. >>> Vitamin B12 analog; SC; rat; 2002; no duration posted; controls received pumps with saline only; pumps replaced after three weeks; cobalamin analog.

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6. Vitamin B12 Analog

1821 Brass, E.P., Allen, R.H., Ruff, L.J., Stabler, S. Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat. Biochem. J 1990; 226(--):809-815. >>> Vitamin B12 analog; SC; rat; 2002; controls received pumps with saline only; pumps replaced after three weeks; cobalamin analog.

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7. Vitamin D

16181 Stephanie R. Sisley,, Deanna M. Arble,, Adam P. Chambers,, Ruth Gutierrez-Aguilar,, Yanlin He,, Yong Xu,, David Gardner,, David D. Moore,, Randy J. Seeley,, Darleen A. Sandoval. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes 2016; (--):1-35. >>> Vitamin D3, 1,25-dyhydroxy; Cyclodextrin; hydroxypropyl-B-; CSF/CNS (third ventricle); Rat; 1004; Controls received mp w/ vehicle; animal info (male, Long Evans, adult); dose-response (Supplementary Figure 3); obesity; Dose (-.264 ug/day); Brain coordinates (i3vt 2.2A/P, 7.8D/V);.

15204 Chaichanasakul, T., Kang, B., Bezouglaia, O., Aghaloo, T.L., Tetradis, S., Tetradis, S. Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone1116. JOURNAL OF PERIODONTOLOGY 2014; 85(--):829-836. >>> Parathyroid hormone (1-34), human; vitamin D3, 1,25-dihydroxy; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 3 months old);.

14226 Hyde, M.L., Fraser, D.R., Fraser, D.R. In vivo measurement of the absorption of strontium in the rumen and small intestine of sheep as an index of calcium absorption capacity. British Journal of Nutrition 2014; 112(--):718-724. >>> Hydroxyvitamin D3, 1a-; SC; Sheep (ewe); 2002; Animal info (merino, mature); functionality of mp verified by plasma 1,125-dihydroxycholecalciferol levels;.

14201 Halder, S.K., Sharan, C., Al-Hendy, O., Al-Hendy, A., Al-Hendy, A. Paricalcitol, a Vitamin D Receptor Activator, Inhibits Tumor Formation in a Murine Model of Uterine Fibroids. REPRODUCTIVE SCIENCES 2014; 21(--):1108-1119. >>> Vitamin D3, 1,25-dihydroxy; PEG; ethanol; SC; Mice (nude); Controls received mp w/ vehicle; animal info (female, athymic, nude, 5-6 weeks old); 95% PEG used; 5% ethanol used; cancer (uterine fibroid tumor);.

12341 Halder, S.K., Sharan, C., Al-Hendy, A. 1,25-Dihydroxyvitamin D3 Treatment Shrinks Uterine Leiomyoma Tumors in the Eker Rat Model. Biology of Reproduction 2012; 86(-4-):U41-U50. >>> Vitamin D3, 1,25-dihydroxy; Ethylene glycol; SC; Rat; Controls received mp w/ vehicle; animal info (female, Eker, 14-16 wks old); functionality of mp verified via serum drug levels; cancer (uterine leiomyomas).

11461 Lamblin, M., Dabbas, B., Spingarn, R., Mendoza-Sanchez, R., Wang, T.T., An, B.S., Huang, D.C., Kremer, R., White, J.H., Gleason, J.L. Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids. BIOORGANIC&MEDICINAL CHEMISTRY 2010; 18(-11-):4119-4137. >>> Vitamin D, 1 alpha 25-dihydroxy; Vitamin D hybrid, 1 alpha 25-dihydroxy; Mice; Animal info (female, virgin, FVB, 8 wks old); cancer; enzyme inhibitor (histone deacetylase, HDAC).

10563 Wong, M.S.K., Delansorne, R., Man, R.Y.K., Svenningsen, P., Vanhoutte, P.M. Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-4-):H1226-H1234. >>> Vitamin D3, 1,25-dihydroxy-; SC; Rat; 2006; Animal info (adult, SHR, WKY, 36 wk old); long-term study.

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8. Vitamin E

11861 Hsieh, C.Y., Liu, C.L., Hsu, M.J., Jayakumar, T., Chou, D.S., Wang, Y.H., Hsiao, G., Sheu, J.R. Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLC-gamma-1 and JAK2 phosphorylation. Free Radical Biology and Medicine 2010; 49(-5-):881-893. >>> PMC; tocopherol, alpha; SC; Rat; Controls received mp w/ normal saline; animal info (Wistar, male, 350-400 g); PMC, also known as (2,2,5,7,8-pentamethyl-6-hydroxychromane, is a vitamin E derivative; tocopherol also known as vitamin E.

9876 Irwin, D.C., McCord, J.M., Nozik-Grayck, E., Beckly, G., Foreman, B., Sullivan, T., White, M., Crossno, JT Jr, Bailey, D., Flores, S.C., Majka, S., Klemm, D., van Patot, M.C.T. A potential role for reactive oxygen species and the HIF-1-alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radical Biology and Medicine 2009; 47(-1-):55-61. >>> Ascorbate; glutathione; tocopherol, alpha-; SC; Mice; 1007D; Controls received mp w/saline; animal info (male, C57BL/6J, 25-30g, 10-12 weeks old); compounds were mixed and infused together as an antioxodant cocktail.

3859 Udaka, T., Misao, T., Aoe, M., Date, H., Andou, A., Shimizu, N. The effect of combination therapy with EPC-K1 and low-dose cyclosporine to pulmonary allograft after rat lung transplantation. J. Heart Lung Transplant 1997; 16(--):839-845. >>> Vitamin E; IP; rat; 2001; functionality of mp verified by measuring EPC-K1 plasma levels; immunology; EPC-K1 is a diester of a-tocopherol and ascorbic acid; agent also called D-alpha-tocopherol.

2009 Stein, D.G., Halks-Miller, M., Hoffman, S.W. Intracerebral administration of alpha-tocopherol-containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex. J. Neurotrauma 1991; 8(-4-):281-292. >>> Phosphatidylcholine; vitamin E; Liposomes; CSF/CNS (cortex); rat; 2001; Multiple pumps per animal (2); agent also called D-alpha-tocopherol.

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What researchers are saying ...

“Galantamine was administered via…osmotic pump… A minipump was used in order to better mimic the daily multiple dosing regimen given to patients with Alzheimer’s disease.” Wenk et al., European Journal of Pharmacology 2003;453:319-324.