References on the Administration of Vitamins Using ALZET^® Osmotic Pumps

1. RO-23-7553

P3719 Light,B.W., Yu,W.-D., McElwain,M.C., Russell,D.M., Trump,D.L., Johnson,C.S. Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res. 1997; 57(--):3759-3764. >>> RO-23-7553; PBS; IP; mice; 1007D; 7 days; controls received sham mp; cancer.

top of page

2. Vitamin B12

P3776 Kiuchi,T., Sei,H., Seno,H., Sano,A., Morita,Y. Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat. Physiol.Behav. 1997; 61(-4-):551-554. >>> Vitamin B12; IP; rat; 2002; 15 days; controls received mp w/saline.

top of page

3. Vitamin B12 Analog

P1825 Brass,E.P., Allen,R.H., Ruff,L.J., Stabler,S. Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat. Biochem.J. 1990; 226(--):809-815. >>> Vitamin B12 analog; SC; rat; 2002; no duration posted; controls received pumps with saline only; pumps replaced after three weeks; cobalamin analog.

top of page

4. Vitamin D

Q0314 Wong,M.S.K., Delansorne,R., Man,R.Y.K., Svenningsen,P., Vanhoutte,P.M. Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-4-):H1226-H1234. >>> Vitamin D3, 1,25-dihydroxy-; SC; Rat; 2006; 6 weeks; Animal info (adult, SHR, WKY, 36 wk old); long-term study.

P8554 Mailhot,G., Petit,J.L., Dion,N., Deschenes,C., Ste-Marie,L.G., Gascon-Barre,M. Endocrine and bone consequences of cyclic nutritional changes in the calcium, phosphate and vitamin D status in the rat: An in vivo depletion-repletion-redepletion study. Bone 2007; 41(-3-):422-436. >>> Vitamin D3; IP; Rat; 14 days; No stress (see pg. 425, 432); animal info (male, Sprague-Dawley, 7 weeks old).

P8289 Banach-Petrosky,W., Ouyang,X.S., Gao,H., Nader,K., Ji,Y., Suh,N., DiPaola,R.S., bate-Shen,C. Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1; Pten mutant mice. Clinical Cancer Research 2006; 12(-19-):5895-5901. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; Mice; 2004; 1-4 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks; stability verified by serum calcium levels; cancer (prostate); animal info (4-7 months old, male).

P8175 Clements,M.R., Johnson,L., Fraser,D.R. A new mechanism for induced vitamin D deficiency in calcium deprivation. Nature 1987; 325(-6099-):62-65. >>> Vitamin D, 1,25-dihydroxy-; SC; Rat; ; Animal info (male, Norwegian hooded).

P7307 Nakagawa,K., Sasaki,Y., Kato,S., Kubodera,N., Okano,T. 22-oxa-1alpha,25-dihydroxyvitamin D3 inhibits metastasis and angiogenesis in lung cancer. Carcinogenesis 2005; 26(-6-):1044-1054. >>> Vitamin D3, 1, 25-dihydroxy-; vitamin D3, 22-oxa-la, 25-dihydroxy-; Tween 20; ethanol; SC; Mice; 2ML4; 3 weeks; 10, 18 days; Controls received mp w/ vehicle; dose-response; cancer (lung carcinoma); 10% ethanol; millipore chamber ring; sc dorsal air sac model.

P7170 Duque,G., Macoritto,M., Dion,N., Ste-Marie,L.G., Kremer,R. 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6). AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2005; 288(-4-):E723-E730. >>> Vitamin D3, 1, 25-dihydroxy-; Mice; 6 weeks; Controls received mp w/ vehicle; pumps replaced after 3 weeks, no stress (see pg. E728).

P6832 Narayanan,R., Allen,M.R., Gaddy,D., Bloomfield,S.A., Smith,C.L., Weigel,N.L. Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089). Bone 2004; 35(-1-):134-143. >>> Vitamin D3, 1,25-dihydroxy; EB 1089; Polypropylene glycol; sodium phosphate; SC; Rat; 28 days; Controls received mp w/ vehicle; functionality of mp verified by plasma 25(OH)-D and 1,25-D levels; stress/adverse reaction: (see pg. 137) 5 animals died due to anesthesia complications and to tail irritation and diarrhea.

P6660 Huang,D.C., Papavasiliou,V., Rhim,J.S., Horst,R.L., Kremer,R. Targeted disruption of the 25-hydroxyvitamin D3 1 alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produce d 1 alpha,25-dihydroxyvitamin D3 suppresses growth and induces differ entiation in an autocrine fashion. MOLECULAR CANCER RESEARCH 2002; 1(-1-):56-67. >>> Vitamin D3, 25-hydroxy-; SC; Mice (SCID); 5.5 weeks; Controls received mp w/ vehicle or agent with no tumor; functionality of mp verified by 25-OHD3 plasma levels; no stress (see pg. 11 and fig.7); cancer (squamous carcinoma).

P6248 Rummens,K., van Bree,R.E., Van Herck,E., Zaman,Z., Bouillon,R., Van Assche,F.A., Verhaeghe,J. Vitamin D deficiency in guinea pigs: Exacerbation of bone phenotype during pregnancy and disturbed fetal mineralization, with recovery by 1, 25(OH)(2)D-3 infusion or dietary calcium-phosphate supplementation. Calcified Tissue International 2002; 71(-4-):364-375. >>> Vitamin D3, 1,25-dihydroxy-; SC; Guinea-pig; 2ML4; 4 weeks.

P6206 Duque,G., Macoritto,M., Kremer,R. Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity. BIOGERONTOLOGY 2004; 5(-6-):421-429. >>> Vitamin D3, 1,25-dihydroxy-; Mice; 2004; 6 weeks; Controls received mp w/ vehicle; pumps replaced after 3 weeks.

P5867 Theodoropoulos,C., Demers,C., Petit,J.L., Gascon-Barre,M. High sensitivity of rat hepatic vitamin D-3-25 hydroxylase CYP27A to 1,25-dihydroxyvitamin D-3 administration. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2003; 284(-1-):E138-E147. >>> Vitamin D3, 125-dihydroxy-; vitamin D3, 25-dihydroxy-; IP; Rat; 1,3,5,7 days; Functionality of mp verified by serum levels (p. E140); dose-response (p. E140); pump model not stated.

P5121 Thierry-Palmer,M., Tewolde,T.K., Forte,C., Wang,M., Bayorh,M.A., Emmett,N.L., White,J., Griffin,K. Plasma 24,25-dihydroxyvitamin D concentration of Dahl salt-sensitive rats decreases during high salt intake. Journal of Steroid Biochemistry and Molecular Biology 2002; 80(--):315-321. >>> Vitamin D3, 24,25-dihydroxy-; Vitamin D3, 25-hydroxy-; Propylene glycol; Ethanol; SC; rat; up to 28 days; controls received mp w/ vehicle; functionality of mp verified by plasma levels; vehicle was 95% PG with 5% ETOH.

P5058 Gill,R., Nazir,T.M., Wali,R., Sitrin,M., Brasitus,T.A., Ramaswamy,K., Dudeja,P.K. Regulation of rat ileal NHE3 by 1,25(OH)(2)-vitamin D-3. Digestive Diseases and Sciences 2002; 47(-5-):1169-1174. >>> Vitamin D3, 1, 25-dihydroxy-; SC; rat; 2001; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum Vitamin D3 levels; streptozotocin induced diabetes, p. 1170.

P4691 Mailhot,G, Petit,J.-L, Demers,C, Gascon-Barré,M. Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes.. Endocrinology 2000; 141(-3-):891-900. >>> Vitamin D;; rat;; 1 week;.

P4614 Silva,I.V, Blaisdell,C.J, Guggino,S.E, Guggino,W.B. PTH regulates expression of ClC-5 chloride channel in the kidney.. Am.J.Physiological.Renal Physiol. 2000; 278(--):F238-F245. >>> Vitamin D; Parathyroid hormone (1-34);; Ringer's solution;; SC;; rat (pregnant);; 1003D;; 3 days;; controls received mp w/vehicle + sham operation; replacement therapy (thyroparathyroidectomy); peptides;.

P4476 Xue,L., Lipkin,M., Newmark,H., Wang,J. Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice.. J.Natl.Cancer Inst. 1999/1/20; 91(--):176-181. >>> Vitamin D; uridine, bromodeoxy-;; SC;; mice;; 1003D;; 3 days;; cancer;.

P3994 Sela-Brown,A., Russell,J., Koszewski,N.J., Michalak,M., Naveh-Many,T., Silver,J. Calreticulin inhibits vitamin D's action on the PTH gene in vitro and may prevent vitamin D's effect in vivo in hypocalcemic rats. Molec.Endocrinol. 1998; 12(-8-):1193-1200. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 7 days; controls received mp w/vehicle.

P3993 Schwarz,U., Amann,K., Orth,S.R., Simonaviciene,A., Wessels,S., Ritz,E. Effect of 1,25 (OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats. Kidney Int. 1998; 53(--):1696-1705. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; rat; 2ML4; no duration posted; controls received mp w/vehicle.

P3992 Saxe,A.W., Gibson,G., Levy,J. Effect of chronic vitamin D infusion upon in vivo glucose disposal. Calcif.Tissue Int. 1999; 64(--):248-251. >>> Vitamin D; Propylene glycol; Ethanol; SC; rat; 2001; 5 days; controls received mp w/vehicle.

P3991 Stabel,J.R., Goff,J.P. Influence of vitamin D3 infusion and dietary calcium on secretion of interleukin 1, interleukin 6 and tumor necrosis factor in mice infected with Mycobacterium paratuberculosis. Am.J.Vet.Res. 1996; 57(-6-):825-829. >>> Vitamin D3, 1,25-dihydroxy-; SC; mice; 14 days; immunology.

P3929 Tordoff,M.G., Hughes,R.L., Pilchak,D.M. Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D. Am.J.Physiol. 1998; 274(-43-):R214-R231. >>> Parathyroid hormone; Calcitonin; Vitamin D, 1,25-dihydroxy-; NaCl; HCl; Cysteine; Saline, isotonic; SC; rat; 2002; 13 days; controls received sham tubing; functionality of mp verified by hormone assays; replacement therapy (thyroidectomy, thyroparathyroidectomy); dose-response; stress/adverse reaction: high doses led to animal death; peptides; agents given singly and in combination.

P3621 Stabel,J.R., Goff,J.P., Whipple,D.L., Ackermann,M.R., Reinhardt,T.A. Low calcium diet and 1,25-dihydroxyvitamin D(3) infusion modulate immune responses during mycobacterium paratuberculosis infection in beige mice. Vet.Immunology and Immnopathology 1996; 50(--):127-143. >>> Vitamin D3, 1,25-dihydroxy-; SC; mice; no duration posted; functionality of mp verified by plasma levels; immunology.

P3606 Tsuji,H., Cawthorn,C., Ecarot,B. Abnormal modulation of serum osteocalcin by dietary phosphate and 1,25-dihydroxyvitamin D3 in the hypophosphatemic mouse. J.Bone and Min.Res. 1996; 11(-9-):1234-1240. >>> Parathyroid hormone; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; Saline; Cysteine; SC; mice; 2001; 3,14 days; controls received mp w/ vehicle; peptides.

P3576 Tordoff,M.G., Hughes,R.L., Pilchak,D.M. Independence of salt intake from the hormones regulating calcium homeostasis. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.33) 1993; 264(--):R500-R512. >>> Parathyroid hormone, bovine; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2001; 2002; 1, 2 weeks; replacement therapy (thyroparathyroidectomy).

P3541 Ecarot,B., Glorieux,F.H., Desbarats,M., Travers,R., Labelle,L. Effect of 1,25-dihydroxyvitamin D3 treatment on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice. J.Bone and Min.Res. 1995; 10(-3-):424-431. >>> Vitamin D3, 1,25-dihydroxy-; Vitamin D3, 24,25-dihydroxy-; Propylene glycol; SC; mice; 2001; 2002; 17 days; pumps replaced at day 6; vitamins given singly and together.

P3281 Meyer,R.A., Meyer,M.H., Gray,R.W., Brault,B.A. Response of jejunal phosphate absorption to 1,25-dihydroxyvitamin D3 stimulation in vivo in young X-linked hypophosphatemic (Hyp) mice. Endocrine 1995; 3(--):209-214. >>> Vitamin D3, 1,25-dihydroxy-; Propanediol, 1,2-; SC; mice; 2001; 4 days; normal and Hyp mice used.

P3198 Hatton,D.C., Xue,H., DeMerritt,J.A., McCarron,D.A. 1,25(OH)2 Vitamin D3-induced alterations in vascular reactivity in the spontaneously hypertensive rat. Am.J.Med.Sci. 1994; 307(-Sup 1-):S154-S158. >>> Vitamin D3, 1,25-dihydroxy-; SC; rat; 2001; 7 days; controls received mp with vehicle; comparison of daily sc injections vs. mp.

P3142 Uhland-Smith,A., DeLuca,H.F. The necessity for calcium for increased renal vitamin D receptor in response to 1,25-dihydroxyvitamin D. Biochim.Biophys.Acta 1993; 1176(--):321-326. >>> Vitamin D3, 1,25-dihydroxy-; SC; rat; 2002; 4,8 weeks; comparison of oral vitamin D-3 vs. mp; long-term study, pumps replaced after 2 weeks.

P2886 Reichel,H., Szabo,A., Uhl,J., Pesian,S., Schmutz,A., Schmidt-Gayk,H., Ritz,E. Intermittent versus continuous administration of 1,25-dihydroxyvitamin D3 in experimental renal hyperparathyroidism. Kidney Int. 1993; 44(--):1259-1265. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2001; 6 days; functionality of mp verified by residual volume, radioactive tracing and serum levels; comparison of i.p. injections vs. mp.

P2853 Rogers,K.V., Dunn,C.K., Conklin,R.L., Hadfield,S., Petty,B.A., Brown,E.M., Hebert,S.C., Nemeth,E.F., Fox,J. Calcium receptor messenger ribonucleic acid levels in the parathyroid glands and kidney of vitamin D-deficient rats are not regulated by plasma calcium or 1,25-dihydroxyvitamin D3. Endocrinology 1995; 136(-2-):499-504. >>> Calcium chloride; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; Ethanol; SC; IV (inferior vena cava); rat; 2002; 2ML1; 7 days; no comment posted.

P2664 Brown,A.J., Finch,J., Grieff,M., Ritter,C., Kubodera,N., Nishii,Y., Slatopolsky,E. The mechanism for the disparate actions of calcitriol and 22-oxacalcitriol in the intestine. Endocrinology 1993; 133(-3-):1158-1164. >>> Oxacalcitriol, 22-; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2002; 3 days; controls received mp w/ vehicle; comparison of ip injections vs. mp; agent is 1,25-(OH)2D3.

P2521 Potter,G.K., Mohamed,A.N., Dracopoli,N.C., Groshen,S.L.B., Shen,R.N., Moore,M.A.S. Response to an active vitamin D3 metabolite of transplantable human myeloid leukemic cell lines in adult nude mice. In 'Experimental Hematology Today--1985,' S.J.Baum, D.H.Pluznick, and L.A.Rozenszajn (eds.), Springer-Verlag New York, Inc. 1986; (--):106-113. >>> Vitamin D3 metabolites; Propylene glycol; SC; mice; 2002; no duration posted; no comment posted.

P2280 Goff,J.P., Reinhardt,T.A., Engstrom,G.W., Horst,R.L. Effect of dietary calcium or phosphorus restriction and 1,25-dihydroxyvitamin D administration on rat intestinal 24-hydroxylase. Endocrinology 1992; 131(-1-):101-104. >>> Vitamin D, 1,25-dihydroxy-; SC; rat; 3,7 days; comparison of ip injections vs mp.

P2142 Shimosawa,T., Ando,K., Fujita,T. Enhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. Hypertension 1993; 21(-2-):253-258. >>> Oxacalcitriol, 22-; Vitamin D3, 24,25-dihydroxy-; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2002; 14 days; no comment posted.

P2073 Fox,J., Kollenkirchen,U. Normal plasma calcium, phosphate, and parathyroid hormone levels during 1,25(OH)2D3 infusions in rats. Am.J.Physiol. 1992; 262(--):E126-E129. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; SC; rat; 2002; 10 days; dose-response graphs (pp. E127-E128); infusion of D3 represents a better approach over injections for determining the physiology of tissue D3 responsiveness.

P1850 Lemire,J.M., Archer,D.C. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J.Clin.Invest. 1991; 87(--):1103-1107. >>> Vitamin D3, 1,25-dihydroxy-; SC; mice; 2001; no duration posted; no comment posted.

P1761 Davidai,G.A., Nesbitt,T., Drezner,M.K. Variable phosphate-mediated regulation of vitamin D metabolism in the murine hypophosphatemic rachitic/osteomalacic disorders. Endocrinology 1991; 128(-3-):1270-1276. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; mice; 2001; 48 hours; no comment posted.

P1759 Stein,B., Halloran,B.P., Reinhardt,T., Engstrom,G.W., Bales,C.W., Drezner,M.K., Currie,K.L., Takizawa,M., Adams,J.S., Epstein,S. Cyclosporin-A increases synthesis of 1,25-dihydroxyvitamin D3 in the rat and mouse. Endocrinology 1991; 128(-3-):1369-1373. >>> Vitamin D3, 1,25-dihydroxy-; Radio-isotopes; SC; rat; 2002; no duration posted; no comment posted.

P1700 Reinhardt,T.A., Horst,R.L. Parathyroid hormone down-regulates 1,25-dihydroxyvitamin D receptors (VDR) and VDR messenger ribonucleic acid in vitro and blocks homologous up-regulation of VDR in vivo. Endocrinology 1990; 127(-2-):942-948. >>> Parathyroid hormone; Vitamin D3, 1,25-dihydroxy-; Cysteine; Ethanol; HCl; Propylene glycol; Saline; rat; 5 days; controls received pumps with saline only; peptides; PTH and vit. D infused separately and concurrently.

P1656 Patel,S., Simpson,R.U., Hsu,C.H. Effect of vitamin D metabolites on calcitriol metabolism in experimental renal failure. Kidney Int. 1989; 36(--):234-239. >>> Calcitriol; Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; SC; rat; 2001; 1 week; functionality of mp verified by measuring residual volume.

P1588 Horst,R.L., Goff,J.P., Reinhardt,T.A. Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor. Endocrinology 1989; 126(-2-):1053-1057. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; rat; 2001; 6 days; no comment posted.

P1576 Naito,Y., Goff,J.P., Horst,R.L., Reinhardt,T.A. Effects of continuous administration of 1,25-dihydroxyvitamin D3 on plasma minerals and unoccupied colon mucosal 1,25-dihydroxyvitamin D3 receptor concentrations. J.Dairy Sci. 1989; 72(--):2936-2941. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; cattle; 2ML1; 7 days; functionality of mp verified by measuring plasma vit. D levels; discusses comparison of IM injections vs. mp; states pump effectively maintained plasma conc. throughout (p. 2939), states conc. achieved via pump may improve vit. D3 therapy for preventing p.

P1540 Szabo,A., Merke,J., Beier,E., Mall,G., Ritz,E. 1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int. 1989; 35(--):1049-1056. >>> Vitamin D3, 1,25-dihydroxy-; Propanol; IP; rat; no duration posted; comparison of IP injections vs. mp infusion.

P1515 Meyer,M.H., Meyer,R.A. Increased intestinal absorption of calcium in young and adult X-linked hypophosphatemic mice after the administration of 1,25-dihydroxyvitamin D3. J.Bone and Min.Res. 1988; 3(-2-):151-157. >>> Vitamin D3, 1,25-dihydroxy-; Propanediol, 1,2-; SC; mice; 2001; 3 days; no comment posted.

P1401 Meyer,R.A., Meyer,M.H., Gray,R.W., Bruns,M.E. Evidence that low plasma 1,25-dihydroxyvitamin D causes intestinal malabsorption of calcium and phosphate in juvenile X-linked hypophosphatemic mice. J.Bone and Min.Res. 1987; 2(-1-):67-82. >>> Vitamin D3, 1,25-dihydroxy-; Propanediol, 1,2-; SC; mice; 2001; 3 days; dose-response; functionality of mp verified by plasma levels.

P1393 Yamato,H., Matsumoto,T., Fukumoto,S., Ikeda,K., Ishizuka,S., Ogata,E. Effect of 24,25-dihydroxyvitamin D3 on 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] metabolism in vitamin D-deficient rats infused with 1,25-(OH)2D3. Endocrinology 1989; 124(-1-):511-517. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; rat; 2002; 7, 10 days; dose-response (serum levels); half-life; functionality of mp verified by serum levels.

P1089 Haddad,P., Coulombe,P.A., Gascon-Barre,M. Influence of the vitamin D hormonal status on the hepatic response to bromobenzene. J.Pharmacol.Exp.Ther. 1987; 242(-1-):354-363. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; Saline; IP; rat; 2001; 8 days; controls received mp w/vehicle.

P1058 Bruns,M.E., Christakos,S., Huang,Y.C., Meyer,M.H., Meyer,R.A. Vitamin D-dependent calcium binding proteins in the kidney and intestine of the X-linked hypophosphatemic mouse: Changes with age and responses to 1,25-dihydroxycholecalciferol. Endocrinology 1987; 121(--):1-6. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 2001; 3 days; controls received mp w/vehicle; mice were hypophosphatemic.

P0927 Wronski,T.J., Halloran,B.P., Bikle,D.D., Globus,R.K., Morey-Holton,E.R. Chronic administration of 1,25-dihydroxyvitamin D3: Increased bone but impaired mineralization. Endocrinology 1986; 119(-6-):2580-2585. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; SC; rat; 2002; 13 days; controls received mp w/vehicle.

P0921 Jobin,J.R., Bonjour,J.P. Compensatory renal growth: Modulation by calcium PTH and 1,25-(OH)2D3. Kidney Int. 1986; 29(--):1124-1130. >>> Parathyroid hormone, bovine; Vitamin D3, 1,25-dihydroxy-; Acetic acid; Albumin; Ethanol; Propylene glycol; Saline; IP; rat; 2001; 3 days; 4 doses of agents infused; replacement therapy (thyroparathyroidectomy); peptides.

P0893 Halloran,B.P., Bikle,D.D., Levens,M.J., Castro,M.E., Globus,R.K., Holton,E. Chronic 1,25-dyhydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J.Clin.Invest. 1986; 78(--):622-628. >>> Radio-isotopes; Vitamin D3, 1,25-dihydroxy-; 3H tracer; Ethanol; Propylene glycol; SC; rat; 2002; 3, 7, 12 days; metabolic clearance rate measured by mp infusion of labelled Vit. D3, see ref. 15&16.

P0781 Nesbitt,T., Drezner,M.K., Lobaugh,B. Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin d-1a-hydroxylase activity in the hypophosphatemic mouse. J.Clin.Invest. 1986; 77(-1-):181-187. >>> Parathyroid hormone, bovine; Vitamin D3, 1,25-dihydroxy-; Cysteine HCl; Propylene glycol; Saline; SC; mice; 2001; 48 hours; mp primed in saline 24 hrs prior to implant; controls received sham pumps; dose-response (plasma levels&kidney conc.); agents infused separately; advantages of mp infusion (see pg. 185); peptides.

P0779 Sonnenberg,J., Luine,V.N., Krey,L.C., Christakos,S. 1,25-dihydroxyvitamin d3 treatment results in increased choline acetyltransferase activity in specific brain nuclei. Endocrinology 1986; 118(-4-):1433-1439. >>> Calcium chloride; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; Saline; CSF/CNS; rat; 2001; 7 days; mp connected to cannula in 3rd ventricle and implanted sc; vitamin d3 administered ip in combination w/mp infusion; controls received mp w/appropriate vehicle; agents administered separately.

P0777 Halloran,B.P., Bikle,D.D., Wronski,T.J., Globus,R.K., Levens,M.J., Morey-Holton,E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology 1986; 118(-3-):948-954. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; SC; rat; 2002; 2 weeks; dose-response (serum conc.).

P0734 Potter,G.K., Mohamed,A.N., Dracopoli,N.C., Groshen,S.L.B., Shen,R.N., Moore,M.A.S. Action of 1,25-(OH)2D3 in nude mice bearing transplantable human myelogenous leukemic cell lines. Exp.Hematol. 1985; 13(--):722-732. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice (nude); 2001; 70 days; mp replaced periodically; long-term study; comparison of various agents iv vs. mp infusion; cancer chemotherapy.

P0646 Marie,P.J., Hott,M., Garba,M.-T. Contrasting effects of 1,25-dihydroxyvitamin D3 on bone matrix and mineral appositional rates in the mouse. Metabolism 1985; 34(-8-):777-783. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 1 week; 3 doses of Vit D3 given; dose-response data.

P0434 Brommage,R., Jarnagin,K., DeLuca,H.F. 1,25-Dihydroxyvitamin D3 normalizes maternal food consumption and pup growth in rats. Am.J.Physiol. 1984; 246(--):E227-E231. >>> Vitamin D3, 1,25-dihydroxy-; Ethanol; Propylene glycol; SC; rat; 2002; 17 days; comparison of single ip injection vs. mp infusion; mp coated w/ Panalog ointment to reduce risk of infection.

P0357 Marie,P.J., Travers,R. Continuous infusion of 1,25-dihydroxyvitamin D3 stimulates bone turnover in the normal young mouse. Calcif.Tissue Int. 1983; 35(--):418-425. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 4 weeks; 4 dose levels tested: 0.05, 0.10, 0.175, and 0.25 ug/kg/day.

P0309 Hefti,E., Trechsel,U., Fleisch,H., Bonjour,J.-P. Nature of calcemic effect of 1,25-dihydroxyvitamin D3 in experimental hypoparathyroidism. Am.J.Physiol. 1983; 244(--):E313-E316. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; IP; rat; 1701; 1 week; no comment posted.

P0304 Brommage,R., Jarnagin,K., DeLuca,H.F., Yamada,S., Takayama,H. 1- But not 24-hydroxylation of vitamin D is required for skeletal mineralization in rats. Am.J.Physiol. 1983; 244(--):E298-E304. >>> Vitamin D3, 1,25-dihydroxy-; Vitamin D3, 25-hydroxy-; Propylene glycol; SC; rat; 2002; no duration posted; comparison of oral vs. sc infusion.

P0303 Jarnagin,K., Brommage,R., DeLuca,H.F., Yamada,S., Takayama,H. 1- But not 24-hydroxylation of vitamin D is required for growth and reproduction in rats. Am.J.Physiol. 1983; 244(--):E290-E297. >>> Vitamin D3, 1,25-dihydroxy-; Vitamin D3, 25-hydroxy-; Propylene glycol; SC; rat; 2002; 20 weeks; comparison of oral vs. sc infusion; mp replaced every 2 weeks; pumps coated w/ Panalog ointment; animals washed w/surg. scrub¬ shaved; long-term study; no stress - p. E296.

P0236 Marie,P.J., Travers,R., Glorieux,F.H. Bone response to phosphate and vitamin D metabolites in the hypophosphatemic male mouse. Calcif.Tissue Int. 1982; 34(--):158-164. >>> Vitamin D3, 24,25-dihydroxy-; Vitamin D3, 25-dihydroxy-; Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 18 days; comparison of agents.

P0234 Marie,P.J., Travers,R., Glorieux,F.H. Healing of bone lesions with 1,25-dihydroxyvitamin D3 in the young X-linked hypophosphatemic male mouse. Endocrinology 1982; 111(-3-):904-911. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 4 weeks; no comment posted.

P0149 Tenenhouse,H.S., Scriver,C.R. Effect of 1,25-dihydroxyvitamin D3 on phosphate homeostasis in the X-linked hypophosphatemic (Hyp) mouse. Endocrinology 1981; 109(-2-):658-660. >>> Vitamin D3, 1,25-dihydroxy-; Propylene glycol; SC; mice; 2001; 10 days; pumps replaced.

top of page

5. Vitamin E

P3759 Udaka,T., Misao,T., Aoe,M., Date,H., Andou,A., Shimizu,N. The effect of combination therapy with EPC-K1 and low-dose cyclosporine to pulmonary allograft after rat lung transplantation. J.Heart Lung Transplant 1997; 16(--):839-845. >>> Vitamin E; IP; rat; 2001; 7 days; functionality of mp verified by measuring EPC-K1 plasma levels; immunology; EPC-K1 is a diester of a-tocopherol and ascorbic acid; agent also called D-alpha-tocopherol.

P2013 Stein,D.G., Halks-Miller,M., Hoffman,S.W. Intracerebral administration of alpha-tocopherol-containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex. J.Neurotrauma 1991; 8(-4-):281-292. >>> Phosphatidylcholine; vitamin E; Liposomes; CSF/CNS (cortex); rat; 2001; 7 days; Multiple pumps per animal (2); agent also called D-alpha-tocopherol.

top of page