References on Wound Healing Studies Using ALZET^® Osmotic Pumps

P8211 Luikart,S.D., Levay-Young,B., Hinkel,T., Shearer,J., Mills,C., Caldwell,M.D., Gyetko,M.R., Oegema,T.R. Mactinin treatment promotes wound-healing-associated inflammation in urokinase knockout mice. Wound Repair and Regeneration 2006; 14(-2-):123-128. >>> Mactinin; glutathione 5-transferase; Saline; SC; Rat; mice (transgenic); 1007D; 1, 7 days; Controls received mp w/ vehicle, or GST; peptides; animal info (Tgu PA-/- or wt; Fisher, 150-200g); Polyvinyl alcohol sponges soaked in agent implanted SC, with mp catheter directed to center of sponge: "osmotic pumps were used to continually deliver the fragment and replenish the mactinin in the sponges" (p.125); wound healing.

P7842 Wu,R.X., Laser,M., Han,H., Varadarajulu,J., Schuh,K., Hallhuber,M., Hu,K., Ertl,G., Hauck,C.R., Ritter,O. Fibroblast migration after myocardial infarction is regulated by transient SPARC expression. JOURNAL OF MOLECULAR MEDICINE-JMM 2006; 84(-3-):241-252. >>> EMD121974; DMSO; PBS; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; ischemia (cardiac); animal info (male, female, C57BL/6, 22-25g., coronary artery ligation-induced MI); agent is a specific integrin a-v inhibitor; 50% DMSO; wound healing.

P7131 Brun,P., Mastrotto,C., Beggiao,E., Stefani,A., Barzon,L., Sturniolo,G.C., Palu,G., Castagliuolo,I. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology 2005; 288(-4-):G621-G629. >>> Neurotensin; PBS; BSA; SC; Mice; 2002; 5 days; Controls received mp w/ vehicle; peptides; wound healing.

P6895 Poonawala,T., Levay-Young,B.K., Hebbel,R.P., Gupta,K. Opioids heal ischemic wounds in the rat. Wound Repair and Regeneration 2005; 13(-2-):165-174. >>> Morphine; PBS; SC; Rat; 8 days; Controls received mp w/ vehicle; comparison of topical opioids and injections vs. mp; wound healing.

P5052 te Velde,E.A., Voest,E.E., van Gorp,J.M., Verheem,A., Hagendoorn,J., Gebbink,M.F., Rinkes,I.H.B. Adverse effects of the antiangiogenic agent angiostatin on the healing of experimental colonic anastomoses. ANNALS OF SURGICAL ONCOLOGY 2002; 9(-3-):303-309. >>> Angiostatin; PBS; SC; mice; 2001; 4-7 days; controls received mp w/ vehicle; stability by mouse cornea neovascularization assay (p. 304); cancer; wound healing; angiogenesis inhibitor.

P4781 Efron,D.T., Most,D., Shi,H.P., Tantry,U.S., Barbul,A. A novel method of studying wound healing.. Journal of Surgical Research 2001; 98(--):16-20. >>> Methylisothiourea,S-; Adenovirus vector; Gene, mouse iNOS cDNA sequence; Saline; Dye, methlene blue; Dye, India black ink; PBS; SC (wound healing site);; rat;; 2001; 2ML1;; 7 days;; Controls received mp w/ saline; functionality of mp verified by dye infusion; gene therapy; enzyme inhibitor; methylisothiourea,S- is an inducible nitric oxide synthase inhibitor (iNOS inhibitor); wound healing; SC-implanted pumps infused 2 hydroxyproline sponges via catheter; initial studies used 2ML1 pumps to infuse dyes in order to assess the feasibility of direct infusion with pumps; iNOS inhibitor infusion was with 2001 pumps; pumps were designed to infuse directly into SC implanted polyvinyl sponges at the wound site; Adenovirus vector was dissolved in PBS; iNOS inhibitor was delivered in saline; diagram of pump-catheter assembly and location (p. 18); "Dye infusion demonstrated both grossly and microscopically excellent delivery of the infusate to wound sponges" (p. 18);.

P4780 Dillard,D.G., Gal,A.A., Roman-Rodriguez,J., White,S., Jacobs,I.N. Transforming growth factor and neutralizing antibodies in subglottic stenosis.. Annals of Otology Rhinology and Laryngology 2001; 110(--):393-400. >>> Transforming growth factor-B1; Antibody, anti-human TGF-B1;; PBS; BSA;; Larynx;; rat;; 1, 7, 21 days;; Controls received mp w/ vehicle; immunology; peptides; special delivery device attached to pump, p. 394; wound healing study;.

P5800 Creemers,E., Cleutjens,J., Smits,J., Heymans,S., Moons,L., Colleen,D., Daemen,M., Carmeliet,P. Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am J Pathol 2000; 156(-6-):1865-1873. >>> Uridine, bromodeoxy-; Mice (knockout); 2001; 7 days; Wound healing.

P4418 Schaffer,M.R., Tantry,U., Thornton,F.J, Barbul,A. Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice.. Eur.J.Surg. 1999; 165(--):262-267. >>> L-NMMA; Aminoguanidine hemisulphate; MITU;; PBS;; IP;; mice;; 10 days;; control received mp w/vehicle; comparison of IP injections vs. mp; wound healing study; MITU is S-methyl isothiouronium, a competitive NO synthase inhibitor..

P4556 Slight,S.H, Chilakamarri,V.K, Nasr,S, Dhalla,A.K, Ramires,F.J.A., Sun,Y, Ganjam,V.K, Weber,K.T. Inhibition of tissue repair by spironolactone: Role of mineralocorticoids in fibrous tissue formation.. Molecular and Cellular Biochemistry. 1998; 189(--):47-54. >>> Aldosterone;; SC;; rat;; 2002;; 2 weeks;; controls received mp w/vehicle; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy); Glucocorticoids; wound healing;.

P4551 Nedelec,B, Dodd,C.M, Scott,P.G, Ghahary,A., Tredget,E.E  Wound Repair and Regeneration 1998/6/1; 6(--):202-212. >>> Interferon-a2b; Saline, sterile; IP; Guinea-pig; 2ML4; 7, 14, 21 days; Controls received mp w/vehicle; wound healing study.

P4129 Rodgers,K.E., Girgis,W., Campeau,J., diZerega,G.S. Reduction of adhesion formation by intraperitoneal administration of Arg-Gly-Asp-containing peptides. Fertility and Sterility 1998; 70(-6-):1131-1138. >>> Peptides, Arg-Gly-Asp-containing; Saline; injury site; rabbit; 2ML1; 7 days; controls received mp w/saline; peptides; wound healing; animals received IM morphine or bupronex analgesia post-operatively.

P3954 Schaffer,M.R., Tantry,U., Efron,P.A., Ahrendt,G.M., Thornton,F.J., Barbul,A. Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 1997; 121(--):513-519. >>> Insulin, human; IP; rat; 10 days; controls received no treatment; no stress (see pg. 519); wound healing.

P3952 Bitar,M.S. Insulin-like growth factor-1 reverses diabetes-induced wound healing impairment in rats. Horm.Metab.Res. 1997; 29(--):383-386. >>> Insulin-like growth factor I; PBS; SC; rat; 14 days; controls received mp w/PBS; tissue perfusion (wound chamber); peptides; recomb. human IGF-I used.

P3924 Koshizuka,S., Kanazawa,K., Kobayashi,N., Takazawa,I., Waki,Y., Shibusawa,H., Shumiya,S. The beneficial effects of recombinant human insulin-like growth factor-1 (IGF-I) on wound healing in severely wounded senescent mice. Jpn.J.Surg. 1997; 27(--):946-952. >>> Insulin-like growth factor I; Saline, physiological; SC; mice; 1007D; 7 days; controls received mp w/ vehicle; no stress (see pg. 948); peptides; wound healing; recomb. human IGF-I used.

P3591 Rodgers,K.E., Girgis,W., Campeau,J.D., diZerega,G.S. Reduction of adhesion formation by intraperitoneal administration of anti-inflammatory peptide 2. J.Invest.Surgery 1997; 10(--):31-36. >>> Anti-inflammatory peptide 2; Tris; wound site; rabbit; 2ML1; 1, 2, 3, 7 days; controls received mp w/ vehicle; tissue perfusion (injury site); immunology; peptides; anti-inflammatory peptide 2 is also known as antinflammin and it's a phospholipase A(2) inhibitor; catheter tubing held in place with 4-0 ethilon suture; wound healing.

P3651 Rodgers,K.E., Girgis,W., Campeau,J.D., diZerega,G.S. Reduction of adhesion formation by intraperitoneal administration of a recombinant hirudin analog. J.Invest.Surgery 1996; 9(--):385-391. >>> Hirudin, recomb. analog; injury site; rabbit; 2ML1; 7 days; controls received mp w/ PBS; tissue perfusion (injury site); immunology; peptides; rabbits were given IM morphine for postoperative pain; wound healing.

P3442 Schaffer,M.R., Tantry,U., Gross,S.S., Wasserkrug,H.L., Barbul,A. Nitric oxide regulates wound healing. J.Surg.Res. 1996; 63(--):237-240. >>> MITU; IP; mice; 10 days; controls received mp w/ PBS; immunology; MITU is S-methyl isothiouronium, a competitive NO synthase inhibitor; wound healing.

P4247 Hollyoak,M.A., Muller,M.J., Meyers,N.A., Williams,W.G., Barrow,R.E., Herndon,D.N. Beneficial wound healing and metabolic effects of clenbuterol in burned and nonburned rats. J.Burn Care Rehabil. 1995; 16(--):233-240. >>> Clenbuterol; Saline; SC; rat; 2ML2; 2ML4; 2,3 weeks; controls received mp w/saline; wound healing study.

P2555 Mueller,R.V., Hunt,T.K., Tokunaga,A., Spencer,E.M. The effect of insulinlike growth factor I on wound healing variables and macrophages in rats. Arch Surg 1994; 129(--):262-265. >>> Insulin-like growth factor I; PBS; rat; 2002; 11 days; controls received sham operation and/or mp w/ vehicle; tissue perfusion (wound healing chamber); replacement therapy (hypophysectomy); peptides; wound healing; recomb. human IGF-1 used.

P2050 Suh,D.Y., Hunt,T.K., Spencer,E.M. Insulin-like growth factor-I reverses the impairment of wound healing induced by corticosteroids in rats. Endocrinology 1992; 131(-5-):2399-2403. >>> Insulin-like growth factor I; PBS; wound site; rat; 7,14 days; tissue perfusion (wound healing site); peptides; pump connected to wound healing chamber by means of a catheter; recomb. human IGF-1 used.

P2043 Kibblewhite,D., Larrabee Jr,W.F., Sutton,D. The effect of relaxin on tissue expansion. Arch Otolaryngol.Head Neck Surg. 1992; 118(--):153-156. >>> Relaxin; Saline; SC; pig; 2ML4; 10.5 weeks; long-term study; stress/adverse reaction: one animal extruded osmotic pump during tissue expansion procedure (p. 154); peptides; half-life (p. 155); wound healing.

P2085 Orita,H., Fukasawa,M., Girgis,W., diZerega  Int.J.Fertil. 1991; 36(-3-):172-177. >>> Tissue plasminogen activator; Saline; IP; rabbit; 2ML1; 7 days; dose-response (table p.174); wound healing.

P1715 Kingsnorth,A.N., Vowles,R., Nash,J.R.G. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br.J.Surg. 1990; 77(--):409-412. >>> Epidermal growth factor; Saline; IP; pig; 5 days; paper incorrectly describes a 4ml capacity pump; wound healing.

P1918 Granstein,R.D., Deak,M.R., Jacques,S.L., Margolis,R.J., Flotte,T.J., Whitaker,D., Long,F.H., Amento,E.P. The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wound model. J.Invest.Dermatol. 1989; 93(-1-):18-27. >>> Interferon-gamma; PBS; Serum, mouse; IP; SC; mice; 2002; 14 days; peptides; wound healing.

P0846 Barbul,A., Knud-Hansen,J., Wasserkrug,H.L., Efron,G. Interleukin 2 enhances wound healing in rats. J.Surg.Res. 1986; 40(--):315-319. >>> Interleukin-2; IP; rat; 2ML1; 7 days; controls received mp w/vehicle; wound healing; functionality of mp verified upon removal; peptides; recomb. human IL-2 used.

P0145 Rudolph,R., Hurn,I., Woodward,M. Use of colchicine to inhibit wound contraction. Am.J.Surg. 1981; 141(--):712-717. >>> Colchicine; Saline; SC; rat; 1702; no duration posted; topical&oral admin. vs. infusion; oral&topical - rabbits, omp&topical - rats; wound healing.