Cancer Research using ALZET® Osmotic Pumps
Cancer research is a multifaceted area of study which is in no way limited to investigations designed to assess the carcinogenic or, indeed, anti-carcinogenic potential of chemical compounds. Increasingly, attention is being paid to the mechanisms of action involved in the generation of cancerous cells, the manner in which anti-tumor therapeutics exert their beneficial effects, and the role endogenous factors may play, both in the facilitation and inhibition of cancerous cell development.
Despite the range of studies involved, one common factor necessary for the success of these investigations is the ability of the researcher to control the delivery of the agents under study in a precise and dependable manner. The ALZET osmotic pump provides a solution, permitting continuous and controlled dosing, thus enabling the researcher to achieve steady state conditions and accurate delivery of diverse compounds, including those of low bioavailability, over prolonged periods of time. The references offered on this web site illustrate the use of ALZET pumps for the successful delivery of carcinogens, anti-cancer drugs, endogenous factors and modulators, monoclonal antibodies, vitamin analogues and antisense oligonucleotides.
In addition, a much utilized method of determining the carcinogenic potential of compounds and the therapeutic efficacy of anticancer treatments has been the measurement of cell proliferation levels in tissues of interest. A major challenge in such studies is the ability to maintain a continuous presence of the chosen cell-labeling agent, as variable levels may result in the researcher failing to detect bursts in cell proliferation. The use of ALZET pumps has been well documented as a means of delivering agents, such as bromodeoxyuridine, at a constant rate, thus ensuring the researcher detects all cell proliferation occurring over the required time period.
The antitumor effects of many chemotherapeutic agents are influenced by schedule of drug administration. ALZET pumps allow cancer researchers to compare the effects of anticancer agents given by infusion and one or more regimens of injection. Examples of recent cancer-related research are included in a list of relevant citations and in the following bibliographies*. If you are interested in a specific agent not listed below, check the index by Agent Administered.
- Antisense Oligonucleotides
- Chemotherapeutic Agents
- Growth Factors
- Injection-Infusion Comparisons (studies which compare the effects of drugs when given by injection and infusion)
- Intratumoral Delivery
- Measuring Cell Proliferation In Vivo (continuous BrdU or3H-thymidine labeling)
- Targeted Delivery
Click here to download the ALZET Cancer Research Fact Sheet, highlighting the most recent and novel cancer research applications using ALZET pumps.
*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.
Looking for references? We can help!
Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.
- Ensure around-the-clock exposure to test agents at predictable levels
- Permit continuous administration of short half-life proteins and peptides
- Provide a convenient method for the chronic dosing of laboratory animals
- Minimize unwanted experimental variables and ensure reproducible, consistent results
- Eliminate the need for nighttime or weekend dosing
- Reduce handling and stress to laboratory animals
- Small enough for use in mice or very young rats
- Allow for targeted delivery of agents to virtually any tissue
- Cost-effective research tool
What researchers are saying...
“Nonspecific toxicity is a common problem associated with in vivo application of antisense oligonucleotides.However, by employing certain strategies including the use of partial rather than complete phosphorothioate modification, reducing the length of the oligonucleotide, and using a steady continuous infusion rather than bolus injections, we were able to minimize such toxicity (Van Kampen & Stoessl, 2000a).” (p. 309) Van Kampen et al., Neuroscience 2003;116:307-314.