Endocrine Research using ALZET® Osmotic Pumps
The study of the action of hormones, hormone analogs, growth factors, and neuropeptides in animal models remains a critical avenue of basic and preclinical research. Continuous, controlled compound administration via ALZET osmotic pumps permits physiological concentrations to be achieved, despite the poor bioavailability or short half-life often associated with such agents. The ability to maintain a continuous presence of a compound is extremely beneficial when determining its effect on physiological response or in replacing the endogenous compound in a hormone deficient model. ALZET pumps have proven to be a useful tool for reliable, long-term delivery of agents while avoiding the stress-related complications induced by repeated handling inherent in frequent dosing schedules.
A wide variety of endocrine substances have been delivered using ALZET pumps. Examples of this work are contained in the following reference lists:
Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.
- Antibodies
- Aldosterone
- Antihypertensive Agents
- Cytokines
- Dexamethasone
- Deoxycorticosterone
- Diabetes Research
- Estrogens
- Follicle Stimulating Hormone
- Glucocorticoids
- Growth Factors
- Growth Hormone
- Hormone Replacement (studies where exogenous hormone effects were determined in the absence of endogenous hormone production)
If you are interested in a specific agent and did not find it listed above, check the index by Agent Administered.
Looking for references? We can help!
ALZET will perform a custom bibliography search for you! ALZET pumps have been used to deliver hundreds of different compounds, including proteins and peptides, in a myriad of different experimental applications. We have recently updated our database, which now contains over 11,000 references that can help you guide your research project!
Pump Advantages
- Ensure around-the-clock exposure to test agents at predictable levels
- Permit continuous administration of short half-life proteins and peptides
- Provide a convenient method for the chronic dosing of laboratory animals
- Minimize unwanted experimental variables and ensure reproducible, consistent results
- Eliminate the need for nighttime or weekend dosing
- Reduce handling and stress to laboratory animals
- Small enough for use in mice or very young rats
- Allow for targeted delivery of agents to virtually any tissue
- Cost-effective research tool