Endocrinology Research with ALZET® Pumps

The study of the action of hormones, hormone analogs, growth factors, and neuropeptides in animal models remains a critical avenue of basic and preclinical research. Continuous andcontrolled compound administration via ALZET osmotic pumps permits physiological concentrations to be achieved, despite the poor bioavailability or short half-life often associated with such agents. The ability to maintain a continuous presence of a compound is extremely beneficial when determining its effect on physiological response or in replacing the endogenous compound in a hormone deficient model. ALZET pumps have proven to be a useful tool for reliable, long-term delivery of agents while avoiding the stress-related complications induced by repeated handling inherent in frequent dosing schedules.

A wide variety of endocrine substances have been delivered using ALZET pumps. Examples of this work are contained in the reference lists* shown below. If you are interested in a specific agent not listed below, check the index by Agent Administered.

 

*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

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Pump Advantages

  • Ensure around-the-clock exposure to test agents at predictable levels
  • Permit continuous administration of short half-life proteins and peptides
  • Provide a convenient method for the chronic dosing of laboratory animals
  • Minimize unwanted experimental variables and ensure reproducible, consistent results
  • Eliminate the need for nighttime or weekend dosing
  • Reduce handling and stress to laboratory animals
  • Small enough for use in mice or very young rats
  • Allow for targeted delivery of agents to virtually any tissue
  • Cost-effective research tool

 

What researchers are saying...

“The implanted pumps offered an advantageous alternative to repeated injections. During drug delivery, no external connection was required, and rats were untethered and unrestrained, thereby minimizing animal handling stress” Zhang et al., Journal of Neurophysiology 2000;84:798-805.