Immunology Research with ALZET® Pumps

Efforts to understand the immune system have necessitated that researchers develop strategies for manipulation of the immune response under experimental conditions. In many cases, the continuous infusion of biological and chemical agents may be critical to mimic the natural immune response, or to minimize toxicity from high dose administration. ALZET osmotic pumps have been instrumental to scientists in the field of immunology, enabling continuous systemic or targeted delivery of antibodies, cytokines, immunosuppressants, antigens, antivirals, or genetic material.

Recent examples of this work are included in a general list of immunology references or in the bibliographies* listed below. If you are interested in a specific agent not listed below, check the index by Agent Administered.

 

*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Pump Advantages

  • Ensure around-the-clock exposure to test agents at predictable levels
  • Permit continuous administration of short half-life proteins and peptides
  • Provide a convenient method for the chronic dosing of laboratory animals
  • Minimize unwanted experimental variables and ensure reproducible, consistent results
  • Eliminate the need for nighttime or weekend dosing
  • Reduce handling and stress to laboratory animals
  • Small enough for use in mice or very young rats
  • Allow for targeted delivery of agents to virtually any tissue
  • Cost-effective research tool

 

What researchers are saying...

“This study demonstrates the value of osmotic pumps as effective delivery vehicles for drugs in wild demersal fish.” (p.1024). “We conclude that the administration of T3 by osmotic pumps is an effective means of creating experimental hyperthyroidism in wild Atlantic cod.Similarly, the administration of methimazole, thiourea, or testosterone with osmotic pumps was effective in rendering cod hypothyroid.” (p.1025) Comeau et al., Transactions of the American Fisheries Society 2003;132:1021-1026.