Neuroscience Research with ALZET® Pumps
By direct intracerebral infusion, ALZET pumps allow researchers to bypass the blood-brain barrier. These pumps can also be used for continuous systemic infusion or targeted delivery to specific sites, such as the spinal cord or peripheral nerves. A variety of agents which have CNS activity have been delivered in this manner, including drugs of abuse, neurotrophic factors, neurotransmitters, and receptor antagonists. Examples of this research are included in the reference lists* shown below. If you are interested in a specific agent not listed below, check the index by Agent Administered.
- ICV Administration (Rats)
- ICV Administration (Mice)
- ICV Administration (all animals)
- Intrathecal Infusion
- Naloxone & Naltrexone
- Neurodegenerative Diseases
- Neurotrophic Factors
- Opioids and Opiate Peptides
- Opioid Receptor Research
- Peptide Delivery to the CNS
- Pain Research
- Solid Tissue Microperfusion
- Spinal Cord Injury Research
- Targeted Delivery to Peripheral Nerves
Click here to watch JoVE video article on ICV delivery methods in mice.
Additional resources relevant to neuroscience research can be ordered from the ALZET Technical Services page:
- Intracranial Peptide Delivery Review by White and Schwartz
- Review on CNS Infusion Methods by T. Hagg
- A newsletter which features information on 'Targeted Delivery to Peripheral Nerves'
- Models of Neurodegenerative Disease
- Mouse CNS Research
*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.
Looking for references? We can help!
Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.
- Ensure around-the-clock exposure to test agents at predictable levels
- Permit continuous administration of short half-life proteins and peptides
- Provide a convenient method for the chronic dosing of laboratory animals
- Minimize unwanted experimental variables and ensure reproducible, consistent results
- Eliminate the need for nighttime or weekend dosing
- Reduce handling and stress to laboratory animals
- Small enough for use in mice or very young rats
- Allow for targeted delivery of agents to virtually any tissue
- Cost-effective research tool
What researchers are saying...
“Several approaches have been tested to improve the anti-tumor activity of cytotoxins and immunotoxins and to decrease toxicity and immunogenicity of these agents.”... “In our current study, we utilized a device for continuous infusion (ALZET pump) of drug as an alternate approach to increase the availability of drug. This approach resulted in improved anti-tumor effect and decreased toxic effects.” “Utilizing this device, IL-13 cytotoxin can be continuously administered systemically in body.” Kawakami et al., Molecular Medicine 2002;8(8):487-494.