Neuroscience Research Using ALZET® Osmotic Pumps
By direct intracerebral infusion, ALZET pumps allow researchers to bypass the blood-brain barrier. These pumps can also be used for continuous systemic infusion or targeted delivery to specific sites, such as the spinal cord or peripheral nerves. A variety of agents which have CNS activity have been delivered in this manner, including drugs of abuse, neurotrophic factors, neurotransmitters, and receptor antagonists. Examples of this research are included in the reference lists below:
Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.
- Intracerebroventricular Administration (Rats)
- Intracerebroventricular Administration (Mice)
- Intracerebroventricular Administration (all animals)
- Intrathecal Infusion
- Naloxone & Naltrexone
- Neurodegenerative Diseases
- Neurotrophic Factors
- Opioids and Opiate Peptides
- Opioid Receptor Research
- Peptide Delivery to the CNS
- Pain Research
- Solid Tissue Microperfusion
- Spinal Cord Injury Research
- Targeted Delivery to Peripheral Nerves
- Tolerance
and Dependence
The following information relevant to neuroscience research can be ordered from the ALZET Technical Services page:
- Intracranial Peptide Delivery Review by White and Schwartz
- Review on CNS Infusion Methods by T. Hagg
- A newsletter which features information on 'Targeted Delivery to Peripheral Nerves'
- Models of Neurodegenerative Disease
- Mouse CNS Research
If you are interested in a specific agent and did not find it listed above, check the index by Agent Administered.
Looking for references? We can help!
ALZET will perform a custom bibliography search for you! ALZET pumps have been used to deliver hundreds of different compounds, including proteins and peptides, in a myriad of different experimental applications. We have recently updated our database, which now contains over 11,000 references that can help you guide your research project!
Pump Advantages
- Ensure around-the-clock exposure to test agents at predictable levels
- Permit continuous administration of short half-life proteins and peptides
- Provide a convenient method for the chronic dosing of laboratory animals
- Minimize unwanted experimental variables and ensure reproducible, consistent results
- Eliminate the need for nighttime or weekend dosing
- Reduce handling and stress to laboratory animals
- Small enough for use in mice or very young rats
- Allow for targeted delivery of agents to virtually any tissue
- Cost-effective research tool