Neuroscience Research with ALZET® Pumps

By direct intracerebral infusion, ALZET pumps allow researchers to bypass the blood-brain barrier. These pumps can also be used for continuous systemic infusion or targeted delivery to specific sites, such as the spinal cord or peripheral nerves. A variety of agents which have CNS activity have been delivered in this manner, including drugs of abuse, neurotrophic factors, neurotransmitters, and receptor antagonists. Examples of this research are included in the reference lists* shown below. If you are interested in a specific agent not listed below, check the index by Agent Administered.

 

Click here to watch JoVE video article on ICV delivery methods in mice.

Additional resources relevant to neuroscience research can be ordered from the ALZET Technical Services page:

  • Intracranial Peptide Delivery Review by White and Schwartz
  • Review on CNS Infusion Methods by T. Hagg
  • A newsletter which features information on 'Targeted Delivery to Peripheral Nerves'
  • Models of Neurodegenerative Disease
  • Mouse CNS Research

*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Pump Advantages

  • Ensure around-the-clock exposure to test agents at predictable levels
  • Permit continuous administration of short half-life proteins and peptides
  • Provide a convenient method for the chronic dosing of laboratory animals
  • Minimize unwanted experimental variables and ensure reproducible, consistent results
  • Eliminate the need for nighttime or weekend dosing
  • Reduce handling and stress to laboratory animals
  • Small enough for use in mice or very young rats
  • Allow for targeted delivery of agents to virtually any tissue
  • Cost-effective research tool

 

What researchers are saying...

“We developed the optic nerve/osmotic pump infusion technique to deliver soluble ligands, agonists, or antagonists directly into the optic nerve.The advantages of this technique are that the infused drugs remain largely confined within the experimental nerve, reducing the impact of potential systemic side effects; mere placement of the catheter and subsequent infusion of the vehicle solution do not promote lesion-like changes within the optic nerve…” Rodgers et al., GLIA 41:180-190; 2003.