Pharmacology Research with ALZET® Pumps
The study of the action of chemicals upon living tissues encompasses a wide range of interests, from assessment of the responses evoked at the subcellular level to those seen in the organism as a whole. The ALZET osmotic pump provides the pharmacologist with a means of delivering diverse compounds for extended periods of time.
The ALZET pump is an invaluable tool for investigating the effect of agents upon receptor populations, where achievement of a constant drug level is essential if stable receptor occupancy is to be realized. The ability to maintain a continuous presence of a drug is also beneficial in determining its effect on protein synthesis or physiological response, or when assessing a drug's potential for inducing tolerance and dependence. In addition, controlled, continuous delivery of compounds is advantageous in bioavailability and pharmacokinetic studies.
The ALZET pump also provides a reliable means of accomplishing targeted delivery of compounds to specific organs or tissues. Precise delivery at the proposed site of action permits a more thorough evaluation of the compound's immediate interaction with the cellular mechanisms of interest. Localized delivery also avoids complications associated with bioavailability and activation of feedback mechanisms, commonly seen after systemic administration. The successful targeted delivery of cell modulators by ALZET pumps has also been utilized to generate animal models of disease states providing valuable tools for use in therapeutic assessment.
ALZET pumps are drug discovery tools which offer enhanced control over test compound levels in plasma and tissues. In pharmacologic research, ALZET pumps have been used in a wide range of applications, including:
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Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 13,500 publications! We can perform a custom search for references relevant to your research.
Researchers are saying...
“We developed the optic nerve/osmotic pump infusion technique to deliver soluble ligands, agonists, or antagonists directly into the optic nerve.The advantages of this technique are that the infused drugs remain largely confined within the experimental nerve, reducing the impact of potential systemic side effects; mere placement of the catheter and subsequent infusion of the vehicle solution do not promote lesion-like changes within the optic nerve…” Rodgers et al., GLIA 41:180-190; 2003.