Pharmacology Research with ALZET® Pumps

The study of the action of chemicals upon living tissues encompasses a wide range of interests, from assessment of the responses evoked at the subcellular level to those seen in the organism as a whole. The ALZET osmotic pump provides the pharmacologist with a means of delivering diverse compounds for extended periods of time.

The ALZET pump is an invaluable tool for investigating the effect of agents upon receptor populations, where achievement of a constant drug level is essential if stable receptor occupancy is to be realized. The ability to maintain a continuous presence of a drug is also beneficial in determining its effect on protein synthesis or physiological response, or when assessing a drug's potential for inducing tolerance and dependence. In addition, controlled, continuous delivery of compounds is advantageous in bioavailability and pharmacokinetic studies.

The ALZET pump also provides a reliable means of accomplishing targeted delivery of compounds to specific organs or tissues. Precise delivery at the proposed site of action permits a more thorough evaluation of the compound's immediate interaction with the cellular mechanisms of interest. Localized delivery also avoids complications associated with bioavailability and activation of feedback mechanisms, commonly seen after systemic administration. The successful targeted delivery of cell modulators by ALZET pumps has also been utilized to generate animal models of disease states providing valuable tools for use in therapeutic assessment.

ALZET pumps are drug discovery tools which offer enhanced control over drug levels in plasma and tissues. They have been used in a wide range of pharmacology research applications. Examples of this work are shown in the bibliographies* listed below. If your agent of interest is not listed below, check the index by Agent Administered.

 

*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

 

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

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What researchers are saying...

“Angiostatin was administered through continuous infusion...the continuous administration of angiogenesis inhibitors has greater therapeutic efficacy than the more commonly used twice-daily injections.” (p. 80) Reijneveld et al., European Journal of Clinical Investigation 2003;33:76-81.

 

What researchers are saying...

“We found recently that 21 d of treatment of rats with SSRIs, at clinically relevant and stable serum concentrations (achieved by the use of osmotic minipumps), caused robust downregulation of the SERT.”... “Studies on the effects of chronic antidepressants on the SERT have resulted in inconsistent reports (Owens and Nemeroff, 1998). Among the factors that may contribute to such inconsistency is the route of drug administration. In most studies of chronic administration of Ads to rats, the drugs are given intraperitoneally or subcutaneously, either once or twice daily. As rats metabolize these drugs more rapidly than humans, such dosage schedules can result in appreciable fluctuations in the serum concentration of drug throughout the day. For certain pharmacologic effects, sustained drug action may be needed” Benmansour et al. The Journal of Neuroscience 2002; 22(15):6766-6772.