Route of Agent Administration

ALZET minipumps can be used for systemic administration when implanted subcutaneously or intraperitoneally. They can be attached to a catheter for intravenous, intra-arterial, or intrathecal infusion. ALZET pumps can also be cannected to brain cannulae for delivery to the cerebral ventricles or brain tissue. ALZET pumps have been used for targeted delivery of test agents to a wide variety of sites, including the spinal cord, spleen, liver, organ or tissue transplants, wound healing sites, etc.

Examples of this research are included in the reference lists* shown below. If you are interested in a specific agent not listed below, check the index by Agent Administered.

 

*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

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Pump Advantages

  • Ensure around-the-clock exposure to test agents at predictable levels
  • Permit continuous administration of short half-life proteins and peptides
  • Provide a convenient method for the chronic dosing of laboratory animals
  • Minimize unwanted experimental variables and ensure reproducible, consistent results
  • Eliminate the need for nighttime or weekend dosing
  • Reduce handling and stress to laboratory animals
  • Small enough for use in mice or very young rats
  • Allow for targeted delivery of agents to virtually any tissue
  • Cost-effective research tool

 

What researchers are saying...

“Several approaches have been tested to improve the anti-tumor activity of cytotoxins and immunotoxins and to decrease toxicity and immunogenicity of these agents.”... “In our current study, we utilized a device for continuous infusion (ALZET pump) of drug as an alternate approach to increase the availability of drug. This approach resulted in improved anti-tumor effect and decreased toxic effects.” “Utilizing this device, IL-13 cytotoxin can be continuously administered systemically in body.” Kawakami et al., Molecular Medicine 2002;8(8):487-494.