Toxicology and Teratology Research with ALZET Pumps
When assessing risk, an understanding of the involved toxicologic mechanisms can be helpful. Areas of recent interest include research on the interplay between immunology and toxicology, the neurotoxicity of a variety of compounds, and research on the process of apoptosis. Controlled, continuous delivery of test agents using ALZET osmotic pumps has proven useful in these areas of research.
Examples of recent work
in these and related areas are included in a general
list of references on toxicology research. Cell proliferation
labeling affords insight into the potential carcinogenesis resulting
from exposure to toxic agents. A well proven and reliable technique
involves the continuous infusion of bromodeoxyuridine. Continuous
exposure to the labeling agent is likely to capture a summation of
cell proliferation activity over several days, and can reduce the
likelihood of overlooking bursts of proliferation.
The ability to infuse agents continuously to pregnant animals can provide insight into a myriad of teratologic effects. ALZET pumps have been used to infuse valproic acid, drugs of abuse, and a variety of agents under teratologic investigation.
A list of references is available on teratology research. A wealth of information regarding the use of ALZET osmotic pumps in toxicology and teratology research can be found in this bibliography* section.
- Measuring Cell Proliferation In Vivo (continuous BrdU or 3H-thymidine labeling)
- Growth Factors
- Injection-Infusion Comparisons (studies which compare the effects of drugs when given by injection and infusion)
- Opioids and Opiate Peptides
If you are interested in a specific agent and did not find it listed above, check the index by Agent Administered.
*Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.
Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.
What researchers are saying...
“In preliminary studies using this model, we observed severe side effects with 5-FU doses beyond 25 mg/kg biweekly injections (mice developed skin ulcers, bleeding and severe diarrhea). Thus, we chose to deliver 5-FU by continuous infusion at an equivalent cumulative dose in order to minimize toxicity. Additionally, studies have demonstrated an increased efficacy of chemotherapeutic agents when administered continuously.” Stoeltzing et al. Int. J. Cancer 2003;104:496-503.