Via a catheter, ALZET pumps can deliver substances into the venous or arterial circulation, into the brain, or into any organ, lumen, or solid tissue. Attachment to a catheter does not alter the delivery rate of the pump. A variety of catheter materials have been used successfully with the pumps. Click here for information about compatibility of ALZET specialized catheters solvents/vehicles.
To operate the pump with a catheter, perform the following steps:
- 200 µl & 2 ml Models: Remove the translucent cap from the end of the flow moderator, revealing a short stainless steel tube protruding from the white flange.100 µl Models: Remove and discard the white plastic flange using scissors or pliers. In doing so, be careful not to bend or crush the stainless steel tube. These three models are designed to be as space efficient as possible for use in smaller animals, so were designed without a translucent cap on the flow moderator. (See method)
- Attach the flow moderator to a piece of catheter tubing. The catheter should have an inside diameter (ID) of approximately 0.76 mm (equal to 0.030 inches). Polyethylene tubing, commonly called PE-60 (ID = 0.76 mm), is a good choice for most applications. After attachment, the catheter should cover the entire length of the stainless steel tube above the white flange (or about 3-4 mm).
- Fill the catheter and attached flow moderator using a syringe. Leave the syringe attached to the distal part of the catheter.
- Fill the ALZET pump (see method).
- 200 µl & 2 ml Models: Insert the flow moderator into the pump until the white flange is flush with the surface of the pump. The syringe attached to the distal end of the catheter can now be removed.100 µl Models: Insert the flow moderator into the pump until the catheter tubing is flush with the surface of the pump. The syringe attached to the distal end of the catheter can now be removed.
- Prime the pumps in sterile saline (see method).