By direct intracerebral infusion, ALZET pumps allow researchers to bypass the blood-brain barrier. These pumps can also be used for continuous systemic infusion or targeted delivery to specific sites, such as the spinal cord or peripheral nerves. A variety of agents which have CNS activity have been delivered in this manner, including drugs of abuse, neurotrophic factors, neurotransmitters, and receptor antagonists. Examples of this research are included in the reference lists* shown below.

mouse in a hand next to an osmotic pump with a brain infusion cannula and catheter attached to it

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to watch a JoVE video article on ICV delivery methods in mice

Additional Neuroscience Research Resources

*Some of these bibliographies have been truncated to keep the document to a reasonable length. These bibliographies are updated frequently. However, you can always contact us to request the most recent list of references, or additional references on your specific agent or research topic of interest.