When assessing risk, an understanding of the involved toxicologic mechanisms can be helpful. Areas of recent interest include research on the interplay between immunology and toxicology, the neurotoxicity of a variety of compounds, and research on the process of apoptosis.
Cell proliferation labeling affords insight into the potential carcinogenesis resulting from exposure to toxic agents. A well proven and reliable technique involves the continuous infusion of bromodeoxyuridine. Continuous exposure to the labeling agent is likely to capture a summation of cell proliferation activity over several days, and can reduce the likelihood of overlooking bursts of proliferation.