The study of the action of hormones, hormone analogs, growth factors, and neuropeptides in animal models remains a critical avenue of basic and preclinical research. Continuous and controlled compound administration via ALZET osmotic pumps permits physiological concentrations to be achieved, despite the poor bioavailability or short half-life often associated with such agents. The ability to maintain a continuous presence of a compound is extremely beneficial when determining its effect on physiological response or in replacing the endogenous compound in a hormone deficient model. ALZET pumps have proven to be a useful tool for reliable, long-term delivery of agents while avoiding the stress-related complications induced by repeated handling inherent in frequent dosing schedules.
A wide variety of endocrine substances have been delivered using ALZET pumps. Examples of this work are contained in the reference lists* shown below. If you are interested in a specific agent not listed below, check the index by Agent Administered.