Injection vs. Infusion

Injections often produce plasma levels that greatly exceed effective concentrations, which can result in toxicity and wasted compound. Between doses, the therapeutic effect vanishes for compounds with short half-lives.

The graph to the right simulates plasma levels of a compound administered by injection compared with infusion by ALZET® Osmotic Pump.

Constant and precise delivery from an ALZET pump allows researchers to understand and optimize the key determinants of drug action, such as the level and duration of drug exposure, and the spatial drug distribution relative to the target tissue. By manipulating these variables, drug effects can be optimized early in preclinical development, allowing clinical studies to be conducted at lower cost and with better results.


What are ALZET Osmotic Pumps?

ALZET® Osmotic Pumps are small, implantable pumps for research in mice, rats, and other laboratory animals.

Sold empty and filled by the researcher, these minipumps deliver drugs, hormones, and other test agents at continuous and controlled rates without the need for external connections or frequent handling. With durations ranging from one day to six weeks, the pumps’ unattended operation eliminates the need for repeated nighttime or weekend dosing by lab personnel. Their use has been described in thousands of studies.

ALZET pumps can deliver systemically when implanted subcutaneously or intraperitoneally or they can be attached to a catheter for targeted delivery in which the effects of a test agent are localized in a particular tissue or organ. These pumps have been used for dosing to a wide variety of sites including the brain, spinal cord, bone, liver, organ or tissue transplants, and wound healing sites.

We also offer a variety of products to simplify your infusion – from brain infusion cannulae to catheters for targeted infusion.  Visit the Products section of this website to learn more.

Please send me:

Advantages of Infusion Dosing:

  • Reduce stress caused by frequent handling
  • Reduce time spent dosing by lab personnel
  • Reduce variability of drug levels in blood and tissues
  • Allow free animal movement and enable group housing
  • Enhance the quality of preclinical research data

What are iPRECIO Programmable Pumps?

The iPRECIO Programmable Pump is an advanced infusion device for drug delivery applications in mice, rats and larger animals. With versatile programmable functions and a refillable reservoir, this implantable infusion pump enables full control over dosing studies and empowers researchers to execute even the most complex dosing protocols, including multiple bolus dosing, variable/constant delivery, escalating drug administration, and more.  Two iPRECIO pump versions are available: the iPRECIO SMP-200 is suitable for implantation in rats and larger animals, and the iPRECIO SMP-310R can be implanted in mice and larger animals.

two pumps side by side with iPRECIO SMP-310R on the left and the iPRECIO SMP-200 on the right