Injections often produce plasma levels that greatly exceed effective concentrations, which can result in toxicity and wasted compound. Between doses, the therapeutic effect vanishes for compounds with short half-lives.
The graph to the right simulates plasma levels of a compound administered by injection compared with infusion by ALZET® Osmotic Pump.
Constant and precise delivery from an ALZET pump allows researchers to understand and optimize the key determinants of drug action, such as the level and duration of drug exposure, and the spatial drug distribution relative to the target tissue. By manipulating these variables, drug effects can be optimized early in preclinical development, allowing clinical studies to be conducted at lower cost and with better results.